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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HSBP1L1 Gene

protein-coding   GIFtS: 37
GCID: GC18P077724

heat shock factor binding protein 1-like 1
  Search for HSBP1L1
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HSBP1L1    

Aliases
for HSBP1L1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Heat Shock Factor Binding Protein 1-Like 11 2
FLJ109671
MGC1897431
Heat Shock Factor-Binding Protein 1-Like Protein 12

External Ids:    HGNC: 372431   Entrez Gene: 4404982   Ensembl: ENSG000002267427   UniProtKB: C9JCN93   

Export aliases for HSBP1L1 gene to outside databases

Previous GC identifer: GC18P074346


Summaries
for HSBP1L1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for HSBP1L1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_025028.14  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for HSBP1L1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for HSBP1L1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSBP1L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q23   Ensembl cytogenetic band:  18q23   HGNC cytogenetic band: 18q23

HSBP1L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSBP1L1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P077724:  view genomic region     (about GC identifiers)

Start:
 77,724,561 bp from pter      End:
 77,730,822 bp from pter
Size:
 6,262 bases      Orientation:
 plus strand

Proteins
for HSBP1L1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HSBPL_HUMAN, C9JCN9 (See protein sequence)
Recommended Name: Heat shock factor-binding protein 1-like protein 1  
Size: 74 amino acids; 8384 Da
Secondary accessions: B2RXG9

Explore the universe of human proteins at neXtProt for HSBP1L1: NX_C9JCN9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_C9JCN9

    • HSBP1L1 Protein expression data from MOPED and PaxDb:    About this image 
    HSBP1L1 Protein Expression
    REFSEQ proteins: NP_001129652.1  
    ENSEMBL proteins: 
     ENSP00000414236   ENSP00000467108  

    Human Recombinant Protein Products for HSBP1L1: 
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    Uscn Proteins for HSBP1L1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019031viral envelope ----

    HSBP1L1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for HSBP1L1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HSBP1L1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR009643 HS1-bd

    Graphical View of Domain Structure for InterPro Entry C9JCN9

    ProtoNet protein and cluster: C9JCN9

    UniProtKB/Swiss-Prot: HSBPL_HUMAN, C9JCN9
    Similarity: Belongs to the HSBP1 family


    Function
    for HSBP1L1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046789host cell surface receptor binding ----
         
    HSBP1L1 for ontologies           About GeneDecksing


    Animal Models:
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    In Situ Assay
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    Pathways & Interactions
    for HSBP1L1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HSBP1L1

    1 Interacting protein for HSBP1L1 (C9JCN93) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NR2F6P105883I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019064viral entry into host cell via membrane fusion with the plasma membrane ----

    HSBP1L1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HSBP1L1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for HSBP1L1
    Search CenterWatch for drugs/clinical trials and news about HSBP1L1 / HSBPL 

    Transcripts
    for HSBP1L1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HSBP1L1 gene: 
    NM_001136180.1  

    Unigene Cluster for HSBP1L1:

    Heat shock factor binding protein 1-like 1
    Hs.191582  [show with all ESTs]
    Unigene Representative Sequence: BM043035
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000451882(uc002lno.4) ENST00000592352 ENST00000589516 ENST00000587347
    ENST00000590571

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    Inhib. RNA
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    Additional cDNA sequence: 

    AK001829.1 BC017654.1 BC040056.2 BC157848.1 

    6 DOTS entries:

    DT.95213004  DT.40301994  DT.87046291  DT.97780265  DT.91889936  DT.75145664 

    5 AceView cDNA sequences:

    AA401438 BX099148 H87293 H87245 AA400006 

    GeneLoc Exon Structure


    Expression
    for HSBP1L1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HSBP1L1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTGTATTTG
    HSBP1L1 Expression
    About this image

    HSBP1L1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeOuter Nuclear LayerMature Rod CellsPhotoreceptors, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HSBP1L1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HSBP1L1

    SOURCE GeneReport for Unigene cluster: Hs.191582
        SABiosciences Custom PCR Arrays for HSBP1L1
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    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HSBP1L1

    Orthologs
    for HSBP1L1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for HSBP1L1 gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Hsbp1l11 , 5 heat shock factor binding protein 1-like 11, 5 76.33(n)1
    75.36(a)1    		   18 (53.35 cM)5
    662551  NM_001136181.11  NP_001129653.11 
     802297585 
    chicken
    (Gallus gallus)    		 Aves HSBP1L16
    		 Uncharacterized protein
    		 54(a)
    		 1 ↔ 1
    		 2(57311158-57314247)


    ENSEMBL Gene Tree for HSBP1L1 (if available)
    TreeFam Gene Tree for HSBP1L1 (if available) 

    Paralogs
    for HSBP1L1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for HSBP1L1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/163 NCBI SNPs in HSBP1L1 are shown (see all 163)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 18 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs80858271,2
    		C--77722617(+) TCCACA/GCTGGC 1 -- us2k10--------
    rs1149621251,2
    		--77722754(+) TGTAAT/CTCACA 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs1916559401,2
    		--77723040(+) AGGCCC/TGCCTG 1 -- us2k10--------
    rs713380771,2
    		C--77723053(+) TCGTAGCGTGCG 
     TCAGC    /-    GCCTC     		1 -- us2k11Minor allele frequency- -:0.50NA 2
    rs739713191,2
    		C--77723152(+) TTCCAC/TCTTTT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1408717021,2
    		--77723201(+) GCTGTC/TGTTTC 1 -- us2k10--------
    rs1494063031,2
    		--77723227(+) GTGGCA/GCGGCT 1 -- us2k10--------
    rs1840019441,2
    		--77723308(+) CCCACC/TGGCTG 1 -- us2k10--------
    rs1448210341,2
    		--77723354(+) ACTTAC/GGTTTG 1 -- us2k10--------
    rs1156059181,2
    		F--77723371(+) TGATTC/GTAGCC 1 -- us2k11Minor allele frequency- G:0.02WA 118

    HapMap Linkage Disequilibrium report for HSBP1L1 (77724561 - 77730822 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HSBP1L1: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for HSBP1L1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for HSBP1L1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HSBP1L1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with HSBP1L1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    2. DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)2 Nusbaum C.... Lander E.S. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for HSBP1L1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HSBP1L1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 440498 HGNC: 37243 AceView: LOC440498 Ensembl:ENSG00000226742 euGenes: HUgn440498
    ECgene: HSBP1L1 H-InvDB: HSBP1L1

    Other Databases showing HSBP1L1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HSBP1L1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HSBP1L1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HSBP1L1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HSBP1L1 gene:
    Search GeneIP for patents involving HSBP1L1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for HSBP1L1 gene

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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
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    von Willebrand factor
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