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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HSBP1L1 Gene

protein-coding   GIFtS: 38
GCID: GC18P077724

Heat Shock Factor Binding Protein 1-Like 1

Microbiology & Infectious Diseases Congress
  Search for HSBP1L1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Heat Shock Factor Binding Protein 1-Like 11 2
Heat Shock Factor-Binding Protein 1-Like Protein 12

External Ids:    HGNC: 372431   Entrez Gene: 4404982   Ensembl: ENSG000002267427   UniProtKB: C9JCN93   

Export aliases for HSBP1L1 gene to outside databases

Previous GC identifer: GC18P074346


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for HSBP1L1 Gene: 
HSBP1L1 (heat shock factor binding protein 1-like 1) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.2  NT_025028.14  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for HSBP1L1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for HSBP1L1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSBP1L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q23   Ensembl cytogenetic band:  18q23   HGNC cytogenetic band: 18q23

HSBP1L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSBP1L1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P077724:  view genomic region     (about GC identifiers)

Start:
77,724,561 bp from pter      End:
77,730,822 bp from pter
Size:
6,262 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HSBPL_HUMAN, C9JCN9 (See protein sequence)
Recommended Name: Heat shock factor-binding protein 1-like protein 1  
Size: 74 amino acids; 8384 Da
Secondary accessions: B2RXG9

Explore the universe of human proteins at neXtProt for HSBP1L1: NX_C9JCN9

Explore proteomics data for HSBP1L1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_C9JCN9

  • HSBP1L1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HSBP1L1 Protein Expression
    REFSEQ proteins: NP_001129652.1  
    ENSEMBL proteins: 
     ENSP00000414236   ENSP00000467108  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR009643 HS1-bd

    Graphical View of Domain Structure for InterPro Entry C9JCN9

    ProtoNet protein and cluster: C9JCN9

    UniProtKB/Swiss-Prot: HSBPL_HUMAN, C9JCN9
    Similarity: Belongs to the HSBP1 family


    HSBP1L1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HSBP1L1

    1 Interacting protein for HSBP1L1 (C9JCN93) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NR2F6P105883I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HSBP1L1 (HSBPL)

    Search CenterWatch for drugs/clinical trials and news about HSBP1L1 / HSBPL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HSBP1L1 gene: 
    NM_001136180.1  

    Unigene Cluster for HSBP1L1:

    Heat shock factor binding protein 1-like 1
    Hs.191582  [show with all ESTs]
    Unigene Representative Sequence: BM043035
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000451882(uc002lno.4) ENST00000592352 ENST00000589516 ENST00000587347
    ENST00000590571
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK001829.1 BC017654.1 BC040056.2 BC157848.1 

    6 DOTS entries:

    DT.95213004  DT.40301994  DT.87046291  DT.97780265  DT.91889936  DT.75145664 

    5 AceView cDNA sequences:

    BX099148 AA401438 H87293 H87245 AA400006 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HSBP1L1 expression in normal human tissues (normalized intensities)      HSBP1L1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGTATTTG
    HSBP1L1 Expression
    About this image


    HSBP1L1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Breast (Uncategorized)
             breast ductal cells   
     
     Uterus (Reproductive System)
             endometrial endothelial cell   
     
     Eye (Sensory Organs)
             Mature Rod Cells Outer Nuclear Layer
     
     Amnion (Extraembryonic Tissues)
             amniotic fluid   
     
     Pancreas (Endocrine System)

    See HSBP1L1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HSBP1L1

    SOURCE GeneReport for Unigene cluster: Hs.191582
        SABiosciences Custom PCR Arrays for HSBP1L1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSBP1L1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for HSBP1L1 gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hsbp1l11 , 5 heat shock factor binding protein 1-like 11, 5 76.33(n)1
    75.36(a)1
      18 (53.35 cM)5
    662551  NM_001136181.11  NP_001129653.11 
     802297585 
    chicken
    (Gallus gallus)
    Aves HSBP1L16
    Uncharacterized protein
    54(a)
    1 ↔ 1
    2(56276632-56279702)


    ENSEMBL Gene Tree for HSBP1L1 (if available)
    TreeFam Gene Tree for HSBP1L1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HSBP1L1 gene
    1 SIMAP similar gene for HSBP1L1 using alignment to 2 protein entries:     HSBPL_HUMAN (see all proteins):
    HSBP1

    HSBP1L1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/195 SNPs in HSBP1L1 are shown (see all 195)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs80858271,2
    C--77722617(+) TCCACA/GCTGGC 1 -- us2k10--------
    rs1149621251,2
    F--77722754(+) TGTAAT/CTCACA 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs1916559401,2
    C--77723040(+) AGGCCC/TGCCTG 1 -- us2k10--------
    rs739713191,2
    C,F--77723152(+) TTCCAC/TCTTTT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1408717021,2
    C--77723201(+) GCTGTC/TGTTTC 1 -- us2k10--------
    rs1494063031,2
    --77723227(+) GTGGCA/GCGGCT 1 -- us2k10--------
    rs1840019441,2
    --77723308(+) CCCACC/TGGCTG 1 -- us2k10--------
    rs1448210341,2
    --77723354(+) ACTTAC/GGTTTG 1 -- us2k10--------
    rs1156059181,2
    C,F--77723371(+) TGATTC/GTAGCC 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1485911481,2
    --77723423(+) TGTGTC/TTTCCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HSBP1L1 (77724561 - 77730822 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for HSBP1L1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv910064CNV Loss21882294
    nsv470437CNV Loss18288195
    nsv910039CNV Loss21882294
    nsv469607CNV Loss16826518
    dgv3492n71CNV Loss21882294
    nsv910009CNV Loss21882294
    nsv428359CNV Gain18775914

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HSBP1L1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with HSBP1L1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    2. DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)2 Nusbaum C.... Lander E.S. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 440498 HGNC: 37243 AceView: LOC440498 Ensembl:ENSG00000226742 euGenes: HUgn440498
    ECgene: HSBP1L1 H-InvDB: HSBP1L1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HSBP1L1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HSBP1L1 gene:
    Search GeneIP for patents involving HSBP1L1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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