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Aliases for HSBP1L1 Gene

Aliases for HSBP1L1 Gene

  • Heat Shock Factor Binding Protein 1 Like 1 2 3 5

External Ids for HSBP1L1 Gene

Previous GeneCards Identifiers for HSBP1L1 Gene

  • GC18P077724
  • GC18P074346

Summaries for HSBP1L1 Gene

GeneCards Summary for HSBP1L1 Gene

HSBP1L1 (Heat Shock Factor Binding Protein 1 Like 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSBP1L1 Gene

Genomics for HSBP1L1 Gene

Regulatory Elements for HSBP1L1 Gene

Enhancers for HSBP1L1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F079959 1.5 FANTOM5 Ensembl ENCODE 31.6 -2.9 -2910 4.0 HDGF HDAC1 PKNOX1 KLF17 FEZF1 DMAP1 RAD21 CBX5 ZNF143 CREM HSBP1L1 RBFADN RBFA TXNL4A PQLC1
GH18F079963 1 ENCODE 32 +0.5 516 2.4 ARID4B ZNF48 ZNF121 GLIS2 PAF1 ZNF263 YY2 SP5 MXD4 PPARG HSBP1L1 RBFADN PARD6G-AS1 TXNL4A
GH18F079856 1.1 FANTOM5 Ensembl ENCODE 23 -107.4 -107443 2.0 HLF EBF1 ZFHX2 POLR2A SMARCA4 CEBPA GLIS1 KLF9 HSBP1L1 PQLC1 PIR34228 GC18M079820 ENSG00000278075
GH18F079910 0.8 Ensembl ENCODE 28.2 -52.4 -52435 2.6 HIC1 SMARCA4 POLR2A TEAD4 ZNF600 MAFK NR2F2 HSBP1L1 PQLC1 RBFADN KCNG2 TXNL4A PIR62681 ENSG00000278075
GH18F080032 1.1 ENCODE 11.3 +69.8 69757 3.1 HDGF ATF1 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF48 ZNF2 RBFADN TXNL4A RBFA ENSG00000267251 ADNP2 HSBP1L1 PQLC1 ENSG00000267127
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HSBP1L1 on UCSC Golden Path with GeneCards custom track

Promoters for HSBP1L1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001037659 339 1401 ARID4B FEZF1 ZNF48 ZNF121 GLIS2 ZNF263 YY2 SP5 MXD4 PPARG

Genomic Location for HSBP1L1 Gene

Chromosome:
18
Start:
79,964,561 bp from pter
End:
79,970,822 bp from pter
Size:
6,262 bases
Orientation:
Plus strand

Genomic View for HSBP1L1 Gene

Genes around HSBP1L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSBP1L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSBP1L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSBP1L1 Gene

Proteins for HSBP1L1 Gene

  • Protein details for HSBP1L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9JCN9-HSBPL_HUMAN
    Recommended name:
    Heat shock factor-binding protein 1-like protein 1
    Protein Accession:
    C9JCN9
    Secondary Accessions:
    • B2RXG9

    Protein attributes for HSBP1L1 Gene

    Size:
    74 amino acids
    Molecular mass:
    8384 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HSBP1L1 Gene

Post-translational modifications for HSBP1L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSBP1L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSBP1L1 Gene

Domains & Families for HSBP1L1 Gene

Protein Domains for HSBP1L1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HSBP1L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

C9JCN9

UniProtKB/Swiss-Prot:

HSBPL_HUMAN :
  • Belongs to the HSBP1 family.
Family:
  • Belongs to the HSBP1 family.
genes like me logo Genes that share domains with HSBP1L1: view

No data available for Gene Families for HSBP1L1 Gene

Function for HSBP1L1 Gene

Gene Ontology (GO) - Molecular Function for HSBP1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IEA --
GO:0046789 host cell surface receptor binding IEA --
genes like me logo Genes that share ontologies with HSBP1L1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSBP1L1 Gene

Localization for HSBP1L1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSBP1L1 gene
Compartment Confidence
nucleus 3
extracellular 2
plasma membrane 1
cytosol 1

Gene Ontology (GO) - Cellular Components for HSBP1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019031 viral envelope IEA --
genes like me logo Genes that share ontologies with HSBP1L1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HSBP1L1 Gene

Pathways & Interactions for HSBP1L1 Gene

SuperPathways for HSBP1L1 Gene

No Data Available

Interacting Proteins for HSBP1L1 Gene

Selected Interacting proteins: C9JCN9-HSBPL_HUMAN for HSBP1L1 Gene via IID

Symbol External ID(s) Details
NR2F6

Gene Ontology (GO) - Biological Process for HSBP1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019064 fusion of virus membrane with host plasma membrane IEA --
GO:1903507 negative regulation of nucleic acid-templated transcription IEA --
genes like me logo Genes that share ontologies with HSBP1L1: view

No data available for Pathways by source and SIGNOR curated interactions for HSBP1L1 Gene

Transcripts for HSBP1L1 Gene

mRNA/cDNA for HSBP1L1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HSBP1L1 Gene

Heat shock factor binding protein 1-like 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSBP1L1 Gene

No ASD Table

Relevant External Links for HSBP1L1 Gene

GeneLoc Exon Structure for
HSBP1L1
ECgene alternative splicing isoforms for
HSBP1L1

Expression for HSBP1L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HSBP1L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HSBP1L1 Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HSBP1L1 Gene



Protein tissue co-expression partners for HSBP1L1 Gene

NURSA nuclear receptor signaling pathways regulating expression of HSBP1L1 Gene:

HSBP1L1

SOURCE GeneReport for Unigene cluster for HSBP1L1 Gene:

Hs.191582
genes like me logo Genes that share expression patterns with HSBP1L1: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HSBP1L1 Gene

Orthologs for HSBP1L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HSBP1L1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia HSBP1L1 34 35
  • 84.76 (n)
cow
(Bos Taurus)
Mammalia HSBP1L1 34
  • 84.02 (n)
chimpanzee
(Pan troglodytes)
Mammalia HSBP1L1 35
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hsbp1l1 34
  • 82.13 (n)
mouse
(Mus musculus)
Mammalia Hsbp1l1 34 16 35
  • 76.33 (n)
chicken
(Gallus gallus)
Aves HSBP1L1 35
  • 51 (a)
OneToOne
Species where no ortholog for HSBP1L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HSBP1L1 Gene

ENSEMBL:
Gene Tree for HSBP1L1 (if available)
TreeFam:
Gene Tree for HSBP1L1 (if available)

Paralogs for HSBP1L1 Gene

(1) SIMAP similar genes for HSBP1L1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HSBP1L1: view

No data available for Paralogs for HSBP1L1 Gene

Variants for HSBP1L1 Gene

Sequence variations from dbSNP and Humsavar for HSBP1L1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs111274795 -- 79,966,773(+) TAATA(A/G)TTTAC intron-variant
rs111535563 -- 79,966,080(+) GCGCC(C/T)GCCAC intron-variant
rs111793737 -- 79,969,636(+) TCTTC(C/T)CCCAG intron-variant
rs112078216 -- 79,968,831(+) AACAT(A/G)CCACA intron-variant
rs112238783 -- 79,968,319(+) AATAA(A/G)TTTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSBP1L1 Gene

Variant ID Type Subtype PubMed ID
nsv577958 CNV gain 21841781
nsv577953 CNV loss 21841781
nsv470437 CNV loss 18288195
nsv469607 CNV loss 16826518
nsv428359 CNV gain 18775914
nsv1065902 CNV gain 25217958
nsv1061450 CNV gain 25217958
esv3643327 CNV loss 21293372
esv3643326 CNV loss 21293372
dgv3412n100 CNV gain 25217958

Variation tolerance for HSBP1L1 Gene

Gene Damage Index Score: 0.20; 4.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSBP1L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSBP1L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSBP1L1 Gene

Disorders for HSBP1L1 Gene

Relevant External Links for HSBP1L1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSBP1L1

No disorders were found for HSBP1L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSBP1L1 Gene

Publications for HSBP1L1 Gene

  1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  2. DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C. … Lander E.S. (Nature 2005) 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for HSBP1L1 Gene

Sources for HSBP1L1 Gene

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