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Aliases for HSBP1L1 Gene

Aliases for HSBP1L1 Gene

  • Heat Shock Factor Binding Protein 1 Like 1 2 3 5

External Ids for HSBP1L1 Gene

Previous GeneCards Identifiers for HSBP1L1 Gene

  • GC18P077724
  • GC18P074346

Summaries for HSBP1L1 Gene

GeneCards Summary for HSBP1L1 Gene

HSBP1L1 (Heat Shock Factor Binding Protein 1 Like 1) is a Protein Coding gene.

Additional gene information for HSBP1L1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSBP1L1 Gene

Genomics for HSBP1L1 Gene

Regulatory Elements for HSBP1L1 Gene

Enhancers for HSBP1L1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18H079959 1.8 FANTOM5 Ensembl ENCODE dbSUPER 31.6 -2.9 -2910 3 HDAC1 HDGF PKNOX1 RB1 ZSCAN4 KLF17 FEZF1 DMAP1 BATF RAD21 HSBP1L1 RBFADN RBFA TXNL4A PQLC1
GH18H079963 1.2 ENCODE dbSUPER 32 +0.5 516 2 ARID4B ZNF121 GLIS2 PAF1 SP5 YY2 MXD4 PPARG ZNF610 GLIS1 HSBP1L1 RBFADN PARD6G-AS1 TXNL4A
GH18H079856 1.2 FANTOM5 Ensembl ENCODE 23 -107.4 -107443 2 HLF USF2 EBF1 GABPA ZFHX2 POLR2A CEBPA GLIS1 KLF9 HSBP1L1 PQLC1 GC18M079820 PIR34228 ENSG00000278075
GH18H079910 0.8 Ensembl ENCODE 28.2 -52.4 -52435 2 POLR2A MAX ZNF600 MAFK NR2F2 HSBP1L1 PQLC1 RBFADN KCNG2 TXNL4A PIR62681 ENSG00000278075
GH18H079950 1.2 ENCODE dbSUPER 12.4 -13.6 -13608 3 FOXA2 ATF1 RB1 ARID4B SIN3A ZBTB40 BRCA1 ZNF121 GLIS2 EGR1 RBFADN TXNL4A HSBP1L1 RBFA PQLC1 GC18M079920 PIR48786
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HSBP1L1 on UCSC Golden Path with GeneCards custom track

Promoters for HSBP1L1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000105398 339 1001 ELF3 TBP ARID4B RAD21 RARA GLIS2 EGR2 THAP11 SP5 CEBPB

Genomic Location for HSBP1L1 Gene

Chromosome:
18
Start:
79,964,561 bp from pter
End:
79,970,822 bp from pter
Size:
6,262 bases
Orientation:
Plus strand

Genomic View for HSBP1L1 Gene

Genes around HSBP1L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSBP1L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSBP1L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSBP1L1 Gene

Proteins for HSBP1L1 Gene

  • Protein details for HSBP1L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9JCN9-HSBPL_HUMAN
    Recommended name:
    Heat shock factor-binding protein 1-like protein 1
    Protein Accession:
    C9JCN9
    Secondary Accessions:
    • B2RXG9

    Protein attributes for HSBP1L1 Gene

    Size:
    74 amino acids
    Molecular mass:
    8384 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HSBP1L1 Gene

Post-translational modifications for HSBP1L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSBP1L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSBP1L1 Gene

Domains & Families for HSBP1L1 Gene

Gene Families for HSBP1L1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HSBP1L1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HSBP1L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

C9JCN9

UniProtKB/Swiss-Prot:

HSBPL_HUMAN :
  • Belongs to the HSBP1 family.
Family:
  • Belongs to the HSBP1 family.
genes like me logo Genes that share domains with HSBP1L1: view

Function for HSBP1L1 Gene

Phenotypes From GWAS Catalog for HSBP1L1 Gene

Gene Ontology (GO) - Molecular Function for HSBP1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IEA --
genes like me logo Genes that share ontologies with HSBP1L1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HSBP1L1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSBP1L1 Gene

Localization for HSBP1L1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSBP1L1 gene
Compartment Confidence
nucleus 3
extracellular 2
plasma membrane 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for HSBP1L1 Gene

Pathways & Interactions for HSBP1L1 Gene

SuperPathways for HSBP1L1 Gene

No Data Available

Interacting Proteins for HSBP1L1 Gene

Selected Interacting proteins: C9JCN9-HSBPL_HUMAN for HSBP1L1 Gene via IID

Symbol External ID(s) Details
NR2F6

Gene Ontology (GO) - Biological Process for HSBP1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903507 negative regulation of nucleic acid-templated transcription IEA --
genes like me logo Genes that share ontologies with HSBP1L1: view

No data available for Pathways by source and SIGNOR curated interactions for HSBP1L1 Gene

Drugs & Compounds for HSBP1L1 Gene

No Compound Related Data Available

Transcripts for HSBP1L1 Gene

mRNA/cDNA for HSBP1L1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HSBP1L1 Gene

Heat shock factor binding protein 1-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HSBP1L1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for HSBP1L1 Gene

No ASD Table

Relevant External Links for HSBP1L1 Gene

GeneLoc Exon Structure for
HSBP1L1
ECgene alternative splicing isoforms for
HSBP1L1

Expression for HSBP1L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSBP1L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HSBP1L1 Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HSBP1L1 Gene



Protein tissue co-expression partners for HSBP1L1 Gene

NURSA nuclear receptor signaling pathways regulating expression of HSBP1L1 Gene:

HSBP1L1

SOURCE GeneReport for Unigene cluster for HSBP1L1 Gene:

Hs.191582

Evidence on tissue expression from TISSUES for HSBP1L1 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with HSBP1L1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSBP1L1 Gene

Orthologs for HSBP1L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HSBP1L1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia HSBP1L1 33 34
  • 84.76 (n)
cow
(Bos Taurus)
Mammalia HSBP1L1 33
  • 84.02 (n)
chimpanzee
(Pan troglodytes)
Mammalia HSBP1L1 34
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hsbp1l1 33
  • 82.13 (n)
mouse
(Mus musculus)
Mammalia Hsbp1l1 33 16 34
  • 76.33 (n)
chicken
(Gallus gallus)
Aves HSBP1L1 34
  • 51 (a)
OneToOne
Species where no ortholog for HSBP1L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HSBP1L1 Gene

ENSEMBL:
Gene Tree for HSBP1L1 (if available)
TreeFam:
Gene Tree for HSBP1L1 (if available)

Paralogs for HSBP1L1 Gene

(1) SIMAP similar genes for HSBP1L1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HSBP1L1: view

No data available for Paralogs for HSBP1L1 Gene

Variants for HSBP1L1 Gene

Sequence variations from dbSNP and Humsavar for HSBP1L1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000043686 -- 79,969,504(+) GAGCC(A/G)TGAAT intron-variant
rs1000079281 -- 79,965,390(+) CAGAG(G/T)TGGGG intron-variant
rs1001393359 -- 79,964,369(+) TGACC(A/G)AGGCC upstream-variant-2KB
rs1001444695 -- 79,969,998(+) TTTGC(C/G)TAGAA intron-variant
rs1001657849 -- 79,964,552(+) CATTG(C/G)GTCCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HSBP1L1 Gene

Variant ID Type Subtype PubMed ID
dgv3412n100 CNV gain 25217958
esv3643326 CNV loss 21293372
esv3643327 CNV loss 21293372
nsv1061450 CNV gain 25217958
nsv1065902 CNV gain 25217958
nsv428359 CNV gain 18775914
nsv469607 CNV loss 16826518
nsv470437 CNV loss 18288195
nsv577953 CNV loss 21841781
nsv577958 CNV gain 21841781

Variation tolerance for HSBP1L1 Gene

Gene Damage Index Score: 0.20; 4.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSBP1L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSBP1L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSBP1L1 Gene

Disorders for HSBP1L1 Gene

Relevant External Links for HSBP1L1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSBP1L1

No disorders were found for HSBP1L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSBP1L1 Gene

Publications for HSBP1L1 Gene

  1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60
  2. DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C … Lander ES (Nature 2005) 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for HSBP1L1 Gene

Sources for HSBP1L1 Gene

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