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Aliases for HSBP1 Gene

Aliases for HSBP1 Gene

  • Heat Shock Factor Binding Protein 1 2 3 5
  • Nasopharyngeal Carcinoma-Associated Antigen 13 3 4
  • NPC-A-13 3 4
  • Heat Shock Factor-Binding Protein 1 3
  • HSF1BP 4

External Ids for HSBP1 Gene

Previous GeneCards Identifiers for HSBP1 Gene

  • GC16P074690
  • GC16P084806
  • GC16P083580
  • GC16P083621
  • GC16P082400
  • GC16P083841
  • GC16P069593

Summaries for HSBP1 Gene

Entrez Gene Summary for HSBP1 Gene

  • The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response. [provided by RefSeq, Jul 2008]

GeneCards Summary for HSBP1 Gene

HSBP1 (Heat Shock Factor Binding Protein 1) is a Protein Coding gene. Among its related pathways are Cellular response to heat stress and Cellular Senescence (REACTOME). Gene Ontology (GO) annotations related to this gene include transcription corepressor activity.

UniProtKB/Swiss-Prot for HSBP1 Gene

  • Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.

Additional gene information for HSBP1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSBP1 Gene

Genomics for HSBP1 Gene

GeneHancer (GH) Regulatory Elements for HSBP1 Gene

Promoters and enhancers for HSBP1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I083803 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 -1.2 -1232 5.5 PKNOX1 MLX ARID4B SIN3A DMAP1 E2F8 ZNF207 ZNF143 SP3 SP5 LOC102724163 HSBP1 GC16P083797
GH16I084498 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 5.9 +695.1 695100 8.4 HDGF PKNOX1 CLOCK ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ZBTB7B SLC30A9 TLDC1 ENSG00000260300 KLHL36 ATP2C2-AS1 HSBP1 ENSG00000261243
GH16I083838 Enhancer 1 Ensembl ENCODE dbSUPER 6 +33.7 33669 5.4 USF1 ZFP64 USF2 EBF1 SP1 ZNF316 POU5F1 EMSY MAFK ZBTB20 HSBP1 LOC102724163 LOC105371370 MLYCD
GH16I083682 Enhancer 0.3 FANTOM5 5.1 -125.4 -125410 0.4 HSBP1 ENSG00000261103 MIR3182
GH16I083095 Enhancer 0.2 ENCODE 5.7 -711.6 -711622 1.2 HSBP1 LOC101928417 LOC105371368 CDH13
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HSBP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HSBP1 gene promoter:

Genomic Locations for HSBP1 Gene

Genomic Locations for HSBP1 Gene
11,895 bases
Plus strand

Genomic View for HSBP1 Gene

Genes around HSBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSBP1 Gene

Proteins for HSBP1 Gene

  • Protein details for HSBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heat shock factor-binding protein 1
    Protein Accession:
    Secondary Accessions:
    • Q53XA8
    • Q7Z5Z3

    Protein attributes for HSBP1 Gene

    76 amino acids
    Molecular mass:
    8544 Da
    Quaternary structure:
    • Homohexamer. Associates with heptad repeats of HSF1 trimers and probably also HSF1 monomers, and with HSP70. Association with HSF1 trimers and HSP70 coincides with attenuation of heat shock response and the conversion of HSF1 trimer to monomer.

    Three dimensional structures from OCA and Proteopedia for HSBP1 Gene

neXtProt entry for HSBP1 Gene

Post-translational modifications for HSBP1 Gene

No Post-translational modifications

Other Protein References for HSBP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSBP1 Gene

Domains & Families for HSBP1 Gene

Gene Families for HSBP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HSBP1 Gene


Suggested Antigen Peptide Sequences for HSBP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the HSBP1 family.
  • Belongs to the HSBP1 family.
genes like me logo Genes that share domains with HSBP1: view

Function for HSBP1 Gene

Molecular function for HSBP1 Gene

UniProtKB/Swiss-Prot Function:
Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.

Phenotypes From GWAS Catalog for HSBP1 Gene

Gene Ontology (GO) - Molecular Function for HSBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity TAS,IEA --
GO:0005515 protein binding IPI 16189514
GO:0042802 identical protein binding IPI 25416956
genes like me logo Genes that share ontologies with HSBP1: view

Phenotypes for HSBP1 Gene

genes like me logo Genes that share phenotypes with HSBP1: view

Animal Models for HSBP1 Gene

MGI Knock Outs for HSBP1:

miRNA for HSBP1 Gene

miRTarBase miRNAs that target HSBP1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HSBP1 Gene

Localization for HSBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSBP1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSBP1 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HSBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9649501
GO:0005654 nucleoplasm TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with HSBP1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HSBP1 Gene

Pathways & Interactions for HSBP1 Gene

genes like me logo Genes that share pathways with HSBP1: view

Gene Ontology (GO) - Biological Process for HSBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II TAS 9649501
GO:0006936 muscle contraction IEA --
GO:0035987 endodermal cell differentiation IEA --
GO:1900034 regulation of cellular response to heat TAS --
genes like me logo Genes that share ontologies with HSBP1: view

No data available for SIGNOR curated interactions for HSBP1 Gene

Drugs & Compounds for HSBP1 Gene

No Compound Related Data Available

Transcripts for HSBP1 Gene

Unigene Clusters for HSBP1 Gene

Heat shock factor binding protein 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSBP1 Gene

No ASD Table

Relevant External Links for HSBP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSBP1 Gene

Protein differential expression in normal tissues from HIPED for HSBP1 Gene

This gene is overexpressed in Nasal epithelium (23.3), Amniocyte (19.4), and Heart (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HSBP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of HSBP1 Gene:


SOURCE GeneReport for Unigene cluster for HSBP1 Gene:


Evidence on tissue expression from TISSUES for HSBP1 Gene

  • Nervous system(5)
  • Muscle(4.3)
  • Lung(3.6)
  • Blood(3.1)
  • Kidney(2.9)
  • Eye(2.7)
  • Liver(2.7)
  • Heart(2.6)
  • Intestine(2.5)
genes like me logo Genes that share expression patterns with HSBP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSBP1 Gene

Orthologs for HSBP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HSBP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HSBP1 33 34
  • 99.56 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 91 (a)
-- 34
  • 91 (a)
-- 34
  • 88 (a)
-- 34
  • 87 (a)
-- 34
  • 87 (a)
-- 34
  • 87 (a)
-- 34
  • 86 (a)
-- 34
  • 86 (a)
-- 34
  • 83 (a)
-- 34
  • 82 (a)
-- 34
  • 80 (a)
-- 34
  • 77 (a)
-- 34
  • 76 (a)
(Bos Taurus)
Mammalia HSBP1 33 34
  • 90.79 (n)
(Canis familiaris)
Mammalia HSBP1 33 34
  • 89.47 (n)
(Mus musculus)
Mammalia Hsbp1 33 16 34
  • 85.09 (n)
(Rattus norvegicus)
Mammalia Hsbp1 33
  • 82.46 (n)
(Ornithorhynchus anatinus)
Mammalia HSBP1 34
  • 79 (a)
(Gallus gallus)
Aves HSBP1 33 34
  • 80.37 (n)
(Anolis carolinensis)
Reptilia HSBP1 34
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hsbp1 33
  • 82.13 (n)
Str.15318 33
(Danio rerio)
Actinopterygii hsbp1a 33
  • 75.85 (n)
HSBP1 34
  • 30 (a)
zgc73224 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4434 33
fruit fly
(Drosophila melanogaster)
Insecta CG5446 34
  • 52 (a)
(Caenorhabditis elegans)
Secernentea hsb-1 34
  • 46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5786 34
  • 66 (a)
Species where no ortholog for HSBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSBP1 Gene

Gene Tree for HSBP1 (if available)
Gene Tree for HSBP1 (if available)

Paralogs for HSBP1 Gene

(1) SIMAP similar genes for HSBP1 Gene using alignment to 2 proteins: Pseudogenes for HSBP1 Gene

genes like me logo Genes that share paralogs with HSBP1: view

No data available for Paralogs for HSBP1 Gene

Variants for HSBP1 Gene

Sequence variations from dbSNP and Humsavar for HSBP1 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000719161 -- 83,813,281(+) C/G downstream_transcript_variant
rs1000739928 -- 83,808,322(+) C/A intron_variant
rs1001901270 -- 83,810,962(+) AGA/A intron_variant
rs1001932175 -- 83,811,153(+) A/G intron_variant
rs1002087343 -- 83,812,711(+) A/C 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for HSBP1 Gene

Variant ID Type Subtype PubMed ID
dgv3054n100 CNV gain 25217958
nsv1064977 CNV loss 25217958
nsv1907 CNV insertion 18451855
nsv573398 CNV gain 21841781
nsv573401 CNV gain 21841781
nsv573405 CNV gain 21841781
nsv833308 CNV loss 17160897

Variation tolerance for HSBP1 Gene

Residual Variation Intolerance Score: 68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 6.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HSBP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSBP1 Gene

Disorders for HSBP1 Gene

Additional Disease Information for HSBP1

No disorders were found for HSBP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSBP1 Gene

Publications for HSBP1 Gene

  1. Crystal structure of the hexamer of human heat shock factor binding protein 1. (PMID: 18767159) Liu X … Rao Z (Proteins 2009) 3 4 22 58
  2. Negative regulation of the heat shock transcriptional response by HSBP1. (PMID: 9649501) Satyal SH … Morimoto RI (Genes & development 1998) 2 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The heat-shock response: regulation and function of heat-shock proteins and molecular chaperones. (PMID: 9493008) Morimoto RI … Cotto JJ (Essays in biochemistry 1997) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for HSBP1 Gene

Sources for HSBP1 Gene

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