HSBP1 Gene
protein-coding GIFtS: 46
GCID: GC16P083841
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heat shock factor binding protein 1
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Aliases for HSBP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Heat Shock Factor Binding Protein 11 2 | | Nasopharyngeal Carcinoma-Associated Antigen 132 3 | | NPC-A-132 3 | | Heat Shock Factor-Binding Protein 12 | | HSF1BP3 |
Export aliases for HSBP1 gene to outside databasesPrevious GC identifers: GC16P074690 GC16P084806 GC16P083580 GC16P083621 GC16P082400 GC16P069593 |
Summaries for HSBP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for HSBP1: The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation ofHSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor bindingprotein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factorinvolved in the HS response. During HS response, HSF1 undergoes conformational transition from an inertnon-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the activetrimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cellsrepresses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survivalof the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shockresponse. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: HSBP1_HUMAN, O75506Function: Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a rolein the suppression of the activation of the stress response during the aging process
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Genomic Views for HSBP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the HSBP1 gene promoter: Bach1 p53 Pax-6 LCR-F1 GATA-1 AREB6 HSF2 COMP1 IRF-7A STAT3 Other transcription factors
Search SABiosciences Chromatin IP Primers for HSBP1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSBP1 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q23.3 Ensembl cytogenetic band: 16q23.3 HGNC cytogenetic band: 16q23.3HSBP1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P083841: view genomic region
(about GC identifiers)
Start:
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83,841,448 bp from pter |
End:
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83,853,342 bp from pter |
Size:
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11,895 bases |
Orientation:
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plus strand |
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Proteins for HSBP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: HSBP1_HUMAN, O75506 (See
protein sequence)Recommended Name: Heat shock factor-binding protein 1 Size: 76 amino acids; 8544 Da
Subunit: Homohexamer. Associates with heptad repeats of HSF1 trimers and problaby also HSF1 monomers, and with HSP70.Association with HSF1 trimers and HSP70 coincides with attenuation of heat shock response and the conversion of HSF1trimer to monomer
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for HSBP1:3CI9 (3D)
 
Secondary accessions: Q53XA8 Q7Z5Z3Explore the universe of human proteins at neXtProt for HSBP1: NX_O75506
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75506 HSBP1 Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins: NP_001528.1 ENSEMBL proteins: ENSP00000392896 ENSP00000458007 ENSP00000456049 Human Recombinant Protein Products for HSBP1:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
HSBP1 for ontologies About GeneDecksing
HSBP1 Antibody Products: Assay Products for HSBP1: |
Protein
Domains / Families for HSBP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HSBP1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O75506ProtoNet protein and cluster: O75506 UniProtKB/Swiss-Prot: HSBP1_HUMAN, O75506Similarity: Belongs to the HSBP1 family |
Function for HSBP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Molecular Function: UniProtKB/Swiss-Prot Summary: HSBP1_HUMAN, O75506Function: Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a rolein the suppression of the activation of the stress response during the aging process Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003714 | transcription corepressor activity |
TAS | 9649501 |
HSBP1 for ontologies About GeneDecksing
Animal Models:
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSBP1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSBP1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HSBP1 (NM_001537) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HSBP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSBP1  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSBP1 |
|
Pathways & Interactions for HSBP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HSBP1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
 5/9 Interacting proteins for HSBP1 (O755062, 3 ENSP000003928964) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
TAS | 9649501 | | GO:0006936 | muscle contraction |
IEA | -- |
HSBP1 for ontologies About GeneDecksing
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Drugs & Compounds for HSBP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for HSBP1 Search CenterWatch for drugs/clinical trials and news about HSBP1 
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Transcripts for HSBP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for HSBP1 gene: NM_001537.3 Unigene Cluster for HSBP1: Heat shock factor binding protein 1 Hs.250899 [show with all ESTs]Unigene Representative Sequence: BX6482545 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000433866(uc002fgy.1) ENST00000570259 ENST00000567382 ENST00000569301 ENST00000567125
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSBP1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSBP1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HSBP1 (NM_001537) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HSBP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSBP1  |
Additional cDNA sequence: AF068754.1 AK026575.1 AK172732.1 AY320409.1 BC007515.2 BX537440.1 BX648254.1 BX648972.1 24/30 DOTS entries (see all 30): DT.95210384 DT.420246 DT.95118674 DT.100038497 DT.100883179 DT.100883187 DT.92448229 DT.86850064 DT.86855778 DT.100883177 DT.100883184 DT.100766147 DT.100883181 DT.120659343 DT.120659348 DT.121275731 DT.95344631 DT.100883178 DT.100883185 DT.120659312 DT.120659357 DT.307968 DT.87079489 DT.91953433 24/750 AceView cDNA sequences (see all 750): BM787093 AU106804 AL702079 AI573260 T31993 AI623577 BU688110 BU195373 BQ219939 AA579587 AA737423 T30062 AI372478 T32607 BX477851 BM456566 BQ440543 AI372476 AI160456 AJ709719 N79793 Z32779 BP345676 AA927773 GeneLoc Exon Structure
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Expression for HSBP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HSBP1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: AATAAAGGTG
 About this image See HSBP1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for HSBP1
SOURCE GeneReport for Unigene cluster: Hs.250899 SABiosciences Custom PCR Arrays for HSBP1
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSBP1 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HSBP1 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSBP1 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSBP1 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSBP1 |
Orthologs for HSBP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for HSBP1 gene from 7/20 species (see all 20) About this table
ENSEMBL Gene Tree for HSBP1 (if available) TreeFam Gene Tree for HSBP1 (if available)  |
Paralogs for HSBP1 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for HSBP1 gene
1 SIMAP similar gene for HSBP1 using alignment to 2 protein entries: HSBP1_HUMAN (see all proteins):HSBP1L1
HSBP1 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for HSBP1 PGOHUM00000248188 PGOHUM00000250728 PGOHUM00000235357
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Genomic Variants for HSBP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 16 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for HSBP1 (83841448 - 83853342 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for HSBP1: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSBP1 |
|
Disorders
/ Diseases for HSBP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HSBP1 for disorders About GeneDecksing
OMIM gene information: 604553
OMIM disorders: --
4 diseases for HSBP1: About MalaCardsnasopharyngitis carcinoma breast cancer neuronitis Export disorders for HSBP1 gene to outside databases
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Publications for HSBP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HSBP1 gene, integrated from 9 sources (see all 16): (articles sorted by number of sources associating them with HSBP1) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Negative regulation of the heat shock transcriptional response by HSBP1. (PubMed id 9649501)1, 2, 3 Satyal S.H.... Morimoto R.I. (1998)
- Crystal structure of the hexamer of human heat shock factor binding protein 1. (PubMed id 18767159)1, 2, 9 Liu X....Rao Z. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The heat-shock response: regulation and function of heat-shock proteins and molecular chaperones. (PubMed id 9493008)1, 3 Morimoto R.I....Cotto J.J. (1997)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- The heat shock-binding protein (HspBP1) protects cell s against the cytotoxic action of the Tag7-Hsp70 complex. (PubMed id 21247889)1 Yashin D.V....Sashchenko L.P. (2011)
- Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
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External Searches for HSBP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
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Genome Databases showing HSBP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HSBP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HSBP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for HSBP1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for HSBP1 gene: Search GeneIP for patents involving HSBP1
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for HSBP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
|
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 | |
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for HSBP1 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSBP1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSBP1 | | OriGene Protein Over-expression Lysate for HSBP1 | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for HSBP1 | | OriGene 3'-UTR Clone for HSBP1 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSBP1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSBP1 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | OriGene Purified Protein for HSBP1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for HSBP1 | | OriGene Custom Protein Services for HSBP1 | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HSBP1 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSBP1 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSBP1 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSBP1 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSBP1 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSBP1 |
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 |  |  |  | |
| | | Search Tocris compounds for HSBP1 |
| |  |  |  |  | | | | | Recombinant Protein for HSBP1 |
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 | | HSBP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSBP1 |
|  |  |  |  | | | Search ThermoFisher Antibodies for HSBP1 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSBP1 |
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