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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HSBP1 Gene

protein-coding   GIFtS: 49
GCID: GC16P083841

Heat Shock Factor Binding Protein 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Heat Shock Factor Binding Protein 11 2
Nasopharyngeal Carcinoma-Associated Antigen 132 3
NPC-A-132 3
Heat Shock Factor-Binding Protein 12
HSF1BP3

External Ids:    HGNC: 52031   Entrez Gene: 32812   Ensembl: ENSG000002309897   OMIM: 6045535   UniProtKB: O755063   

Export aliases for HSBP1 gene to outside databases

Previous GC identifers: GC16P074690 GC16P084806 GC16P083580 GC16P083621 GC16P082400 GC16P069593


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HSBP1 Gene:
The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation
of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor
binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a
transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition
from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with
the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in
mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe
effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a
negative regulator of heat shock response. (provided by RefSeq, Jul 2008)

GeneCards Summary for HSBP1 Gene: 
HSBP1 (heat shock factor binding protein 1) is a protein-coding gene. Diseases associated with HSBP1 include nasopharyngitis, and breast cancer. GO annotations related to this gene include transcription corepressor activity.

UniProtKB/Swiss-Prot: HSBP1_HUMAN, O75506
Function: Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a
role in the suppression of the activation of the stress response during the aging process




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HSBP1 gene promoter:
         Bach1   p53   Pax-6   LCR-F1   GATA-1   AREB6   HSF2   COMP1   IRF-7A   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHSBP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for HSBP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q23.3   Ensembl cytogenetic band:  16q23.3   HGNC cytogenetic band: 16q23.3

HSBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSBP1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P083841:  view genomic region     (about GC identifiers)

Start:
83,841,448 bp from pter      End:
83,853,342 bp from pter
Size:
11,895 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HSBP1_HUMAN, O75506 (See protein sequence)
Recommended Name: Heat shock factor-binding protein 1  
Size: 76 amino acids; 8544 Da
Subunit: Homohexamer. Associates with heptad repeats of HSF1 trimers and problaby also HSF1 monomers, and with
HSP70. Association with HSF1 trimers and HSP70 coincides with attenuation of heat shock response and the
conversion of HSF1 trimer to monomer
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for HSBP1:
3CI9 (3D)    
Secondary accessions: Q53XA8 Q7Z5Z3

Explore the universe of human proteins at neXtProt for HSBP1: NX_O75506

Explore proteomics data for HSBP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75506

  • HSBP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HSBP1 Protein Expression
    REFSEQ proteins: NP_001528.1  
    ENSEMBL proteins: 
     ENSP00000392896   ENSP00000458007   ENSP00000456049  

    Human Recombinant Protein Products for HSBP1: 
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    Novus Biologicals HSBP1 Proteins
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    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for HSBP1
    Cloud-Clone Corp. Proteins for HSBP1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005856cytoskeleton IEA--

    HSBP1 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for HSBP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR009643 HS1-bd

    Graphical View of Domain Structure for InterPro Entry O75506

    ProtoNet protein and cluster: O75506

    UniProtKB/Swiss-Prot: HSBP1_HUMAN, O75506
    Similarity: Belongs to the HSBP1 family


    HSBP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HSBP1_HUMAN, O75506
    Function: Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a
    role in the suppression of the activation of the stress response during the aging process

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity TAS9649501
         
    HSBP1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HSBP1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HSBP1 
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    miRNA
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    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate HSBP1 (see all 32):
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    SwitchGear 3'UTR luciferase reporter plasmidHSBP1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HSBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/17 Interacting proteins for HSBP1 (O755062, 3 ENSP000003928964) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=2 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=2 
    ENSG00000215328P081073I2D: score=2 
    ENSG00000224501P081073I2D: score=2 
    ENSG00000231555P081073I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS9649501
    GO:0006936muscle contraction IEA--

    HSBP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HSBP1

    Search CenterWatch for drugs/clinical trials and news about HSBP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HSBP1 gene: 
    NM_001537.3  

    Unigene Cluster for HSBP1:

    Heat shock factor binding protein 1
    Hs.250899  [show with all ESTs]
    Unigene Representative Sequence: BX648254
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000433866(uc002fgy.1) ENST00000570259 ENST00000567382 ENST00000569301
    ENST00000567125
    miRNA
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    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate HSBP1 (see all 32):
    hsa-miR-1271 hsa-miR-374a hsa-miR-449a hsa-miR-3167 hsa-miR-421 hsa-miR-1244 hsa-miR-649 hsa-miR-1323
    SwitchGear 3'UTR luciferase reporter plasmidHSBP1 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSBP1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSBP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSBP1

    Additional mRNA sequence: 

    AF068754.1 AK026575.1 AK172732.1 AY320409.1 BC007515.2 BX537440.1 BX648254.1 BX648972.1 

    24/30 DOTS entries (see all 30):

    DT.95210384  DT.420246  DT.95118674  DT.100038497  DT.100883179  DT.100883187  DT.92448229  DT.86850064 
    DT.86855778  DT.100883177  DT.100883184  DT.100766147  DT.100883181  DT.120659343  DT.120659348  DT.121275731 
    DT.95344631  DT.100883178  DT.100883185  DT.120659312  DT.120659357  DT.307968  DT.87079489  DT.91953433 

    24/750 AceView cDNA sequences (see all 750):

    AA737423 AA576681 BE781313 BM845832 AI573260 BQ219639 BP344674 AW089203 
    AA749246 BE881334 AV718370 BG941608 BP345676 AI308823 F33825 BE252102 
    W05591 BF726294 BM982714 BP377233 AW026110 AA832521 BX477851 D80222 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HSBP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAAAGGTG
    HSBP1 Expression
    About this image


    See HSBP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HSBP1

    SOURCE GeneReport for Unigene cluster: Hs.250899
        SABiosciences Custom PCR Arrays for HSBP1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSBP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HSBP1 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hsbp11 , 5 heat shock factor binding protein 11, 5 85.09(n)1
    88.16(a)1
      8 (67.54 cM)5
    681961  NM_024219.11  NP_077181.11 
     1193445385 
    chicken
    (Gallus gallus)
    Aves HSBP11 heat shock factor binding protein 1 80.37(n)
    94.52(a)
      415813  NM_001112809.1  NP_001106280.1 
    lizard
    (Anolis carolinensis)
    Reptilia HSBP16
    Uncharacterized protein
    84(a)
    1 ↔ 1
    GL343849.1(126730-129488)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX854812.12   -- 82.98(n)    BX854812.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc732242 hypothetical protein MGC73224 82.78(n)   393727  BC059566.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG54466
    --
    51(a)
    1 ↔ 1
    2L(12426631-12427709)
    worm
    (Caenorhabditis elegans)
    Secernentea hsb-16
    Protein HSB-1
    45(a)
    1 ↔ 1
    IV(12565993-12567228)


    ENSEMBL Gene Tree for HSBP1 (if available)
    TreeFam Gene Tree for HSBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HSBP1 gene
    1 SIMAP similar gene for HSBP1 using alignment to 2 protein entries:     HSBP1_HUMAN (see all proteins):
    HSBP1L1

    HSBP1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for HSBP1
    PGOHUM00000248188 PGOHUM00000250728 PGOHUM00000235357


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/172 SNPs in HSBP1 are shown (see all 172)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1875429201,2
    --83839532(+) GAACCA/GGGGAG 1 -- us2k10--------
    rs349262901,2
    C--83839628(+) AAAAA-/AAAAGT 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1444889941,2
    C--83839713(+) GGGTGC/TCCCCT 1 -- us2k10--------
    rs1165948441,2
    F--83839739(+) AAGAAC/TGACTT 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1924635961,2
    --83839898(+) GTTTCC/TTAACG 1 -- us2k10--------
    rs758790701,2
    F--83839962(+) TCTTCT/CGAGGA 1 -- us2k11Minor allele frequency- C:0.02EA 120
    rs1466183481,2
    --83839989(+) AGATAC/TTTTTA 1 -- us2k10--------
    rs1838010471,2
    --83840032(+) ACCAGC/TTGACA 1 -- us2k10--------
    rs1398864701,2
    --83840047(+) CCAATA/TACAAA 1 -- us2k10--------
    rs1498144971,2
    --83840059(+) AAGTTC/GTGTAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HSBP1 (83841448 - 83853342 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for HSBP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv1907CNV Insertion18451855
    nsv833308CNV Loss17160897
    nsv907036CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604553    OMIM disorders: --

    3 diseases for HSBP1:    About MalaCards
    nasopharyngitis    breast cancer    neuronitis


    HSBP1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): HSBP1

    Export disorders for HSBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HSBP1 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with HSBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Negative regulation of the heat shock transcriptional response by HSBP1. (PubMed id 9649501)1, 2, 3 Satyal S.H.... Morimoto R.I. (1998)
    2. Crystal structure of the hexamer of human heat shock factor binding protein 1. (PubMed id 18767159)1, 2, 9 Liu X....Rao Z. (2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The heat-shock response: regulation and function of heat-shock proteins and molecular chaperones. (PubMed id 9493008)1, 3 Morimoto R.I....Cotto J.J. (1997)
    5. VCP phosphorylation-dependent interaction partners pre vent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (2013)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. The heat shock-binding protein (HspBP1) protects cell s against the cytotoxic action of the Tag7-Hsp70 complex. (PubMed id 21247889)1 Yashin D.V....Sashchenko L.P. (2011)
    9. Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement. (PubMed id 20235792)4 Uhl G.R....Munafo M.R. (2010)
    10. Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3281 HGNC: 5203 AceView: HSBP1 Ensembl:ENSG00000230989 euGenes: HUgn3281
    ECgene: HSBP1 H-InvDB: HSBP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HSBP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HSBP1 gene:
    Search GeneIP for patents involving HSBP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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