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Aliases for HSBP1 Gene

Aliases for HSBP1 Gene

  • Heat Shock Factor Binding Protein 1 2 3
  • Nasopharyngeal Carcinoma-Associated Antigen 13 3 4
  • NPC-A-13 3 4
  • Heat Shock Factor-Binding Protein 1 3
  • HSF1BP 4

External Ids for HSBP1 Gene

Summaries for HSBP1 Gene

Entrez Gene Summary for HSBP1 Gene

  • The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response. [provided by RefSeq, Jul 2008]

GeneCards Summary for HSBP1 Gene

HSBP1 (Heat Shock Factor Binding Protein 1) is a Protein Coding gene. Diseases associated with HSBP1 include nasopharyngeal carcinoma. GO annotations related to this gene include transcription corepressor activity.

UniProtKB/Swiss-Prot for HSBP1 Gene

  • Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSBP1 Gene

Genomics for HSBP1 Gene

Genomic Location for HSBP1 Gene

Start:
83,807,843 bp from pter
End:
83,819,737 bp from pter
Size:
11,895 bases
Orientation:
Plus strand

Genomic View for HSBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSBP1 Gene

Regulatory Elements for HSBP1 Gene

Proteins for HSBP1 Gene

  • Protein details for HSBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75506-HSBP1_HUMAN
    Recommended name:
    Heat shock factor-binding protein 1
    Protein Accession:
    O75506
    Secondary Accessions:
    • Q53XA8
    • Q7Z5Z3

    Protein attributes for HSBP1 Gene

    Size:
    76 amino acids
    Molecular mass:
    8544 Da
    Quaternary structure:
    • Homohexamer. Associates with heptad repeats of HSF1 trimers and problaby also HSF1 monomers, and with HSP70. Association with HSF1 trimers and HSP70 coincides with attenuation of heat shock response and the conversion of HSF1 trimer to monomer.

    Three dimensional structures from OCA and Proteopedia for HSBP1 Gene

neXtProt entry for HSBP1 Gene

Proteomics data for HSBP1 Gene at MOPED

Post-translational modifications for HSBP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSBP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HSBP1 Gene

Domains for HSBP1 Gene

Protein Domains for HSBP1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

HSBP1_HUMAN
Family:
  • Belongs to the HSBP1 family.:
    • O75506
genes like me logo Genes that share domains with HSBP1: view

No data available for Gene Families for HSBP1 Gene

Function for HSBP1 Gene

Molecular function for HSBP1 Gene

UniProtKB/Swiss-Prot Function: Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process

Gene Ontology (GO) - Molecular Function for HSBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity TAS 9649501
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with HSBP1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HSBP1 Gene

Localization for HSBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSBP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSBP1 Gene COMPARTMENTS Subcellular localization image for HSBP1 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HSBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9649501
GO:0005654 nucleoplasm TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with HSBP1: view

Pathways for HSBP1 Gene

SuperPathways for HSBP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HSBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS 9649501
GO:0006936 muscle contraction IEA --
GO:0034605 cellular response to heat TAS --
GO:0035987 endodermal cell differentiation IEA --
GO:1900034 regulation of cellular response to heat TAS --
genes like me logo Genes that share ontologies with HSBP1: view

No data available for Pathways by source for HSBP1 Gene

Transcripts for HSBP1 Gene

mRNA/cDNA for HSBP1 Gene

Unigene Clusters for HSBP1 Gene

Heat shock factor binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HSBP1 Gene

No ASD Table

Relevant External Links for HSBP1 Gene

GeneLoc Exon Structure for
HSBP1
ECgene alternative splicing isoforms for
HSBP1

Expression for HSBP1 Gene

mRNA expression in normal human tissues for HSBP1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSBP1 Gene

SOURCE GeneReport for Unigene cluster for HSBP1 Gene Hs.250899

genes like me logo Genes that share expressions with HSBP1: view

Orthologs for HSBP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HSBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSBP1 36
  • 99.56 (n)
  • 100 (a)
HSBP1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HSBP1 36
  • 90.79 (n)
  • 98.68 (a)
HSBP1 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HSBP1 36
  • 89.47 (n)
  • 97.37 (a)
HSBP1 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hsbp1 36
  • 85.09 (n)
  • 88.16 (a)
Hsbp1 16
Hsbp1 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 88 (a)
OneToMany
-- 37
  • 87 (a)
OneToMany
-- 37
  • 83 (a)
OneToMany
-- 37
  • 91 (a)
OneToMany
-- 37
  • 86 (a)
OneToMany
-- 37
  • 77 (a)
OneToMany
-- 37
  • 82 (a)
OneToMany
-- 37
  • 76 (a)
OneToMany
-- 37
  • 87 (a)
OneToMany
-- 37
  • 86 (a)
OneToMany
-- 37
  • 80 (a)
OneToMany
-- 37
  • 87 (a)
OneToMany
-- 37
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia HSBP1 37
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hsbp1 36
  • 82.46 (n)
  • 88.16 (a)
chicken
(Gallus gallus)
Aves HSBP1 36
  • 80.37 (n)
  • 94.52 (a)
HSBP1 37
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSBP1 37
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hsbp1 36
  • 82.13 (n)
  • 89.86 (a)
Str.15318 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4434 36
zebrafish
(Danio rerio)
Actinopterygii HSBP1 37
  • 30 (a)
OneToOne
hsbp1a 36
  • 75.85 (n)
  • 85.51 (a)
zgc73224 36
fruit fly
(Drosophila melanogaster)
Insecta CG5446 37
  • 52 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea hsb-1 37
  • 46 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5786 37
  • 66 (a)
OneToOne
Species with no ortholog for HSBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSBP1 Gene

ENSEMBL:
Gene Tree for HSBP1 (if available)
TreeFam:
Gene Tree for HSBP1 (if available)

Paralogs for HSBP1 Gene

Selected SIMAP similar genes for HSBP1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for HSBP1 Gene

genes like me logo Genes that share paralogs with HSBP1: view

No data available for Paralogs for HSBP1 Gene

Variants for HSBP1 Gene

Sequence variations from dbSNP and Humsavar for HSBP1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs4522 -- 83,812,593(+) TTGGT(A/G)TTTAT utr-variant-3-prime
rs9633 -- 83,811,520(+) TATAT(A/T)ATAAA utr-variant-3-prime
rs14772 -- 83,811,714(-) GACAA(A/G)AAAAA utr-variant-3-prime
rs1610864 -- 83,810,045(-) ACCTT(-/AAT)TATTA intron-variant
rs1802381 -- 83,809,394(+) GTGAA(A/C)ACAAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for HSBP1 Gene

Variant ID Type Subtype PubMed ID
nsv833308 CNV Loss 17160897
nsv1907 CNV Insertion 18451855
nsv907036 CNV Loss 21882294

Relevant External Links for HSBP1 Gene

HapMap Linkage Disequilibrium report
HSBP1

Disorders for HSBP1 Gene

(1) MalaCards Diseases for HSBP1 Gene

Search for HSBP1 Gene in MalaCards »

Relevant External Links for HSBP1

Genetic Association Database (GAD)
HSBP1
genes like me logo Genes that share disorders with HSBP1: view

No data available for UniProtKB/Swiss-Prot for HSBP1 Gene

Publications for HSBP1 Gene

  1. Crystal structure of the hexamer of human heat shock factor binding protein 1. (PMID: 18767159) Liu X. … Rao Z. (Proteins 2009) 3 4 23
  2. Negative regulation of the heat shock transcriptional response by HSBP1. (PMID: 9649501) Satyal S.H. … Morimoto R.I. (Genes Dev. 1998) 2 3 4
  3. The heat-shock response: regulation and function of heat-shock proteins and molecular chaperones. (PMID: 9493008) Morimoto R.I. … Cotto J.J. (Essays Biochem. 1997) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for HSBP1 Gene

Sources for HSBP1 Gene

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