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Aliases for HS6ST3 Gene

Aliases for HS6ST3 Gene

  • Heparan Sulfate 6-O-Sulfotransferase 3 2 3
  • HS6ST-3 3 4
  • Heparan-Sulfate 6-O-Sulfotransferase 3 3
  • EC 2.8.2.- 4
  • EC 2.8.2 63

External Ids for HS6ST3 Gene

Previous GeneCards Identifiers for HS6ST3 Gene

  • GC00U991292
  • GC13P091871
  • GC13P095579
  • GC13P095183
  • GC13P094441
  • GC13P095541
  • GC13P096743

Summaries for HS6ST3 Gene

Entrez Gene Summary for HS6ST3 Gene

  • Heparan sulfate (HS) sulfotransferases, such as HS6ST3, modify HS to generate structures required for interactions between HS and a variety of proteins. These interactions are implicated in proliferation and differentiation, adhesion, migration, inflammation, blood coagulation, and other diverse processes (Habuchi et al., 2000 [PubMed 10644753]).[supplied by OMIM, Mar 2008]

GeneCards Summary for HS6ST3 Gene

HS6ST3 (Heparan Sulfate 6-O-Sulfotransferase 3) is a Protein Coding gene. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include sulfotransferase activity. An important paralog of this gene is HS6ST2.

UniProtKB/Swiss-Prot for HS6ST3 Gene

  • 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3-phosphoadenosine 5-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HS6ST3 Gene

Genomics for HS6ST3 Gene

Regulatory Elements for HS6ST3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HS6ST3 Gene

96,090,839 bp from pter
96,839,562 bp from pter
748,724 bases
Plus strand

Genomic View for HS6ST3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HS6ST3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HS6ST3 Gene

Proteins for HS6ST3 Gene

  • Protein details for HS6ST3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heparan-sulfate 6-O-sulfotransferase 3
    Protein Accession:
    Secondary Accessions:
    • Q5W0L0
    • Q68CW6

    Protein attributes for HS6ST3 Gene

    471 amino acids
    Molecular mass:
    54844 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HS6ST3 Gene

Proteomics data for HS6ST3 Gene at MOPED

Post-translational modifications for HS6ST3 Gene

  • Glycosylation at Asn117, Asn128, Asn231, Asn324, Asn329, and Asn380
  • Modification sites at PhosphoSitePlus

Other Protein References for HS6ST3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for HS6ST3 (Heparan Sulfate 6-O-Sulfotransferase 3/HS6ST3)

Domains for HS6ST3 Gene

Gene Families for HS6ST3 Gene

  • SULTM :Sulfotransferases, membrane-bound

Protein Domains for HS6ST3 Gene

Suggested Antigen Peptide Sequences for HS6ST3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8IZP7
  • Belongs to the sulfotransferase 6 family.
genes like me logo Genes that share domains with HS6ST3: view

Function for HS6ST3 Gene

Molecular function for HS6ST3 Gene

UniProtKB/Swiss-Prot CatalyticActivity: 3-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3,5-bisphosphate + [heparan sulfate]-glucosamine 6-sulfate
UniProtKB/Swiss-Prot Function: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3-phosphoadenosine 5-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate

Enzyme Numbers (IUBMB) for HS6ST3 Gene

Gene Ontology (GO) - Molecular Function for HS6ST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008146 sulfotransferase activity --
GO:0017095 heparan sulfate 6-O-sulfotransferase activity IEA --
genes like me logo Genes that share ontologies with HS6ST3: view

Animal Model Products

CRISPR Products

miRNA for HS6ST3 Gene

miRTarBase miRNAs that target HS6ST3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HS6ST3

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HS6ST3 Gene

Localization for HS6ST3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HS6ST3 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for HS6ST3 Gene COMPARTMENTS Subcellular localization image for HS6ST3 gene
Compartment Confidence
extracellular 3
endoplasmic reticulum 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for HS6ST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HS6ST3: view

Pathways for HS6ST3 Gene

genes like me logo Genes that share pathways with HS6ST3: view

Interacting Proteins for HS6ST3 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000365895 for HS6ST3 Gene via STRING

Gene Ontology (GO) - Biological Process for HS6ST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification IEA --
genes like me logo Genes that share ontologies with HS6ST3: view

Compounds for HS6ST3 Gene

(1) HMDB Compounds for HS6ST3 Gene

Compound Synonyms Cas Number PubMed IDs
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
genes like me logo Genes that share compounds with HS6ST3: view

Transcripts for HS6ST3 Gene

Unigene Clusters for HS6ST3 Gene

Heparan sulfate 6-O-sulfotransferase 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HS6ST3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for HS6ST3
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HS6ST3 Gene

No ASD Table

Relevant External Links for HS6ST3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HS6ST3 Gene

mRNA expression in normal human tissues for HS6ST3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HS6ST3 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (6.9), Brain - Anterior cingulate cortex (BA24) (6.0), and Artery - Tibial (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HS6ST3 Gene

SOURCE GeneReport for Unigene cluster for HS6ST3 Gene Hs.171001

genes like me logo Genes that share expressions with HS6ST3: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HS6ST3 Gene

Orthologs for HS6ST3 Gene

This gene was present in the common ancestor of animals.

Orthologs for HS6ST3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HS6ST3 35
  • 99.46 (n)
  • 99.2 (a)
HS6ST3 36
  • 91 (a)
(Bos Taurus)
Mammalia HS6ST3 35
  • 90.02 (n)
  • 91.93 (a)
HS6ST3 36
  • 89 (a)
(Canis familiaris)
Mammalia HS6ST3 36
  • 86 (a)
(Mus musculus)
Mammalia Hs6st3 35
  • 89.15 (n)
  • 93.62 (a)
Hs6st3 16
Hs6st3 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
(Rattus norvegicus)
Mammalia Hs6st3 35
  • 89.91 (n)
  • 93.82 (a)
(Gallus gallus)
Aves HS6ST3 35
  • 78.98 (n)
  • 81.25 (a)
HS6ST3 36
  • 83 (a)
(Anolis carolinensis)
Reptilia HS6ST3 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hs6st3 35
  • 72.02 (n)
  • 77.7 (a)
(Danio rerio)
Actinopterygii -- 35
hs6st3a 36
  • 62 (a)
hs6st3b 35
  • 68.61 (n)
  • 72.02 (a)
hs6st3b 36
  • 69 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hs6st 36
  • 35 (a)
(Caenorhabditis elegans)
Secernentea hst-6 36
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
Species with no ortholog for HS6ST3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HS6ST3 Gene

Gene Tree for HS6ST3 (if available)
Gene Tree for HS6ST3 (if available)

Paralogs for HS6ST3 Gene

Paralogs for HS6ST3 Gene

Selected SIMAP similar genes for HS6ST3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HS6ST3: view

Variants for HS6ST3 Gene

Sequence variations from dbSNP and Humsavar for HS6ST3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs3864 -- 96,836,095(-) TCTGC(G/T)GGCAT utr-variant-3-prime
rs377676 -- 96,391,404(-) CAAAT(A/G)ACTAT intron-variant
rs384431 -- 96,449,642(+) ATACG(A/T)GCATA intron-variant
rs386042 -- 96,429,564(+) TGTAT(A/G)AGTTC intron-variant
rs401152 -- 96,424,513(+) caact(A/G)gatag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HS6ST3 Gene

Variant ID Type Subtype PubMed ID
nsv7246 OTHER Inversion 18451855
nsv900936 CNV Gain 21882294
esv27253 CNV Loss 19812545
esv2663826 CNV Deletion 23128226
nsv507727 CNV Insertion 20534489
esv271439 CNV Insertion 20981092
esv2673647 CNV Deletion 23128226
nsv1136 CNV Loss 18451855
nsv521410 CNV Loss 19592680
dgv376e199 CNV Deletion 23128226
esv21470 CNV Loss 19812545
nsv519951 CNV Loss 19592680
esv2659824 CNV Deletion 23128226
nsv900937 CNV Loss 21882294
esv2535297 CNV Deletion 19546169
esv2678219 CNV Deletion 23128226
nsv900938 CNV Loss 21882294
nsv522493 CNV Loss 19592680
esv2668959 CNV Deletion 23128226
nsv900939 CNV Loss 21882294
nsv517907 CNV Loss 19592680
esv2747851 CNV Deletion 23290073
esv2273382 CNV Deletion 18987734
esv2747853 CNV Deletion 23290073
nsv516784 CNV Gain+Loss 19592680
esv2676311 CNV Deletion 23128226

Relevant External Links for HS6ST3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HS6ST3 Gene

Disorders for HS6ST3 Gene

Relevant External Links for HS6ST3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HS6ST3: view

No data available for UniProtKB/Swiss-Prot for HS6ST3 Gene

Publications for HS6ST3 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine. (PMID: 10644753) Habuchi H. … Kimata K. (J. Biol. Chem. 2000) 3 23
  3. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  4. Stem domains of heparan sulfate 6-O-sulfotransferase are required for Golgi localization, oligomer formation and enzyme activity. (PMID: 15226404) Nagai N. … Kimata K. (J. Cell. Sci. 2004) 3
  5. An evaluation of the assembly of an approximately 15-Mb region on human chromosome 13q32-q33 linked to bipolar disorder and schizophrenia. (PMID: 11991713) Christian S.L. … Gershon E.S. (Genomics 2002) 3

Products for HS6ST3 Gene

Sources for HS6ST3 Gene

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