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Aliases for HS6ST3 Gene

Aliases for HS6ST3 Gene

  • Heparan Sulfate 6-O-Sulfotransferase 3 2 3 5
  • HS6ST-3 3 4
  • EC 2.8.2.- 4
  • EC 2.8.2 63

External Ids for HS6ST3 Gene

Previous GeneCards Identifiers for HS6ST3 Gene

  • GC00U991292
  • GC13P091871
  • GC13P095579
  • GC13P095183
  • GC13P094441
  • GC13P095541
  • GC13P096743

Summaries for HS6ST3 Gene

Entrez Gene Summary for HS6ST3 Gene

  • Heparan sulfate (HS) sulfotransferases, such as HS6ST3, modify HS to generate structures required for interactions between HS and a variety of proteins. These interactions are implicated in proliferation and differentiation, adhesion, migration, inflammation, blood coagulation, and other diverse processes (Habuchi et al., 2000 [PubMed 10644753]).[supplied by OMIM, Mar 2008]

GeneCards Summary for HS6ST3 Gene

HS6ST3 (Heparan Sulfate 6-O-Sulfotransferase 3) is a Protein Coding gene. Among its related pathways are heparan sulfate biosynthesis and Glycosaminoglycan metabolism. GO annotations related to this gene include sulfotransferase activity and heparan sulfate 6-O-sulfotransferase activity. An important paralog of this gene is HS6ST2.

UniProtKB/Swiss-Prot for HS6ST3 Gene

  • 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3-phosphoadenosine 5-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HS6ST3 Gene

Genomics for HS6ST3 Gene

Regulatory Elements for HS6ST3 Gene

Enhancers for HS6ST3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HS6ST3 on UCSC Golden Path with GeneCards custom track

Promoters for HS6ST3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HS6ST3 on UCSC Golden Path with GeneCards custom track

Genomic Location for HS6ST3 Gene

96,090,536 bp from pter
96,839,562 bp from pter
749,027 bases
Plus strand

Genomic View for HS6ST3 Gene

Genes around HS6ST3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HS6ST3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HS6ST3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HS6ST3 Gene

Proteins for HS6ST3 Gene

  • Protein details for HS6ST3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heparan-sulfate 6-O-sulfotransferase 3
    Protein Accession:
    Secondary Accessions:
    • Q5W0L0
    • Q68CW6

    Protein attributes for HS6ST3 Gene

    471 amino acids
    Molecular mass:
    54844 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HS6ST3 Gene

Proteomics data for HS6ST3 Gene at MOPED

Post-translational modifications for HS6ST3 Gene

  • Glycosylation at Asn 117, Asn 128, Asn 231, Asn 324, Asn 329, and Asn 380
  • Modification sites at PhosphoSitePlus

Other Protein References for HS6ST3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for HS6ST3 (Heparan Sulfate 6-O-Sulfotransferase 3/HS6ST3)

Domains & Families for HS6ST3 Gene

Gene Families for HS6ST3 Gene

Protein Domains for HS6ST3 Gene

Suggested Antigen Peptide Sequences for HS6ST3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sulfotransferase 6 family.
  • Belongs to the sulfotransferase 6 family.
genes like me logo Genes that share domains with HS6ST3: view

Function for HS6ST3 Gene

Molecular function for HS6ST3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3,5-bisphosphate + [heparan sulfate]-glucosamine 6-sulfate.
UniProtKB/Swiss-Prot Function:
6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3-phosphoadenosine 5-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.

Enzyme Numbers (IUBMB) for HS6ST3 Gene

genes like me logo Genes that share phenotypes with HS6ST3: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HS6ST3 Gene

Localization for HS6ST3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HS6ST3 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for HS6ST3 Gene COMPARTMENTS Subcellular localization image for HS6ST3 gene
Compartment Confidence
extracellular 3
endoplasmic reticulum 2
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for HS6ST3 Gene

Pathways & Interactions for HS6ST3 Gene

genes like me logo Genes that share pathways with HS6ST3: view

Interacting Proteins for HS6ST3 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000365895 for HS6ST3 Gene via STRING

Gene Ontology (GO) - Biological Process for HS6ST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with HS6ST3: view

No data available for SIGNOR curated interactions for HS6ST3 Gene

Drugs & Compounds for HS6ST3 Gene

(2) Additional Compounds for HS6ST3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
genes like me logo Genes that share compounds with HS6ST3: view

Transcripts for HS6ST3 Gene

Unigene Clusters for HS6ST3 Gene

Heparan sulfate 6-O-sulfotransferase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HS6ST3 Gene

No ASD Table

Relevant External Links for HS6ST3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HS6ST3 Gene

mRNA expression in normal human tissues for HS6ST3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HS6ST3 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.9), Brain - Anterior cingulate cortex (BA24) (x6.0), and Artery - Tibial (x4.0).

Protein differential expression in normal tissues from HIPED for HS6ST3 Gene

This gene is overexpressed in Placenta (50.2) and Gallbladder (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HS6ST3 Gene

SOURCE GeneReport for Unigene cluster for HS6ST3 Gene Hs.171001

genes like me logo Genes that share expression patterns with HS6ST3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for HS6ST3 Gene

Orthologs for HS6ST3 Gene

This gene was present in the common ancestor of animals.

Orthologs for HS6ST3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HS6ST3 35
  • 90.02 (n)
  • 91.93 (a)
HS6ST3 36
  • 89 (a)
(Mus musculus)
Mammalia Hs6st3 35
  • 89.15 (n)
  • 93.62 (a)
Hs6st3 16
Hs6st3 36
  • 95 (a)
(Pan troglodytes)
Mammalia HS6ST3 35
  • 99.46 (n)
  • 99.2 (a)
HS6ST3 36
  • 91 (a)
(Rattus norvegicus)
Mammalia Hs6st3 35
  • 89.91 (n)
  • 93.82 (a)
(Canis familiaris)
Mammalia HS6ST3 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
(Gallus gallus)
Aves HS6ST3 35
  • 78.98 (n)
  • 81.25 (a)
HS6ST3 36
  • 83 (a)
(Anolis carolinensis)
Reptilia HS6ST3 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hs6st3 35
  • 72.02 (n)
  • 77.7 (a)
(Danio rerio)
Actinopterygii -- 35
hs6st3b 35
  • 68.61 (n)
  • 72.02 (a)
hs6st3a 36
  • 62 (a)
hs6st3b 36
  • 69 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hs6st 36
  • 35 (a)
(Caenorhabditis elegans)
Secernentea hst-6 36
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
Species with no ortholog for HS6ST3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HS6ST3 Gene

Gene Tree for HS6ST3 (if available)
Gene Tree for HS6ST3 (if available)

Paralogs for HS6ST3 Gene

Paralogs for HS6ST3 Gene

(2) SIMAP similar genes for HS6ST3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HS6ST3: view

Variants for HS6ST3 Gene

Sequence variations from dbSNP and Humsavar for HS6ST3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs9516771 - 96,832,576(+) TTGGA(A/G)AACCT reference, missense
rs3864 -- 96,836,095(-) TCTGC(G/T)GGCAT utr-variant-3-prime
rs401152 -- 96,424,513(+) caact(A/G)gatag intron-variant
rs404177 -- 96,424,576(+) AGATG(A/G)AGGTG intron-variant
rs411581 -- 96,430,178(-) GAAAG(A/G)CTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HS6ST3 Gene

Variant ID Type Subtype PubMed ID
nsv7246 OTHER Inversion 18451855
nsv900936 CNV Gain 21882294
esv27253 CNV Loss 19812545
esv2663826 CNV Deletion 23128226
nsv507727 CNV Insertion 20534489
esv271439 CNV Insertion 20981092
esv2673647 CNV Deletion 23128226
nsv1136 CNV Loss 18451855
nsv521410 CNV Loss 19592680
dgv376e199 CNV Deletion 23128226
esv21470 CNV Loss 19812545
nsv519951 CNV Loss 19592680
esv2659824 CNV Deletion 23128226
nsv900937 CNV Loss 21882294
esv2535297 CNV Deletion 19546169
esv2678219 CNV Deletion 23128226
nsv900938 CNV Loss 21882294
nsv522493 CNV Loss 19592680
esv2668959 CNV Deletion 23128226
nsv900939 CNV Loss 21882294
nsv517907 CNV Loss 19592680
esv2747851 CNV Deletion 23290073
esv2273382 CNV Deletion 18987734
esv2747853 CNV Deletion 23290073
nsv516784 CNV Gain+Loss 19592680
esv2676311 CNV Deletion 23128226

Variation tolerance for HS6ST3 Gene

Residual Variation Intolerance Score: 71.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.06; 60.75% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HS6ST3 Gene

Disorders for HS6ST3 Gene

Relevant External Links for HS6ST3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HS6ST3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HS6ST3 Gene

Publications for HS6ST3 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine. (PMID: 10644753) Habuchi H. … Kimata K. (J. Biol. Chem. 2000) 3 23
  3. Heritability and genetic association analysis of cognition in theA Diabetes Heart Study. (PMID: 24684796) Cox A.J. … Bowden D.W. (Neurobiol. Aging 2014) 3
  4. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. (PMID: 23563607) Berndt S.I. … Ingelsson E. (Nat. Genet. 2013) 3
  5. Association of HS6ST3 gene polymorphisms with obesity and triglycerides: gene x gender interaction. (PMID: 24371161) Wang K.S. … Zeng M. (J. Genet. 2013) 3

Products for HS6ST3 Gene

Sources for HS6ST3 Gene