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Aliases for HS6ST2 Gene

Aliases for HS6ST2 Gene

  • Heparan Sulfate 6-O-Sulfotransferase 2 2 3
  • HS6ST-2 3 4
  • Heparan-Sulfate 6-O-Sulfotransferase 2 3
  • EC 2.8.2.- 4
  • EC 2.8.2 63

External Ids for HS6ST2 Gene

Previous GeneCards Identifiers for HS6ST2 Gene

  • GC0XM126407
  • GC0XM128605
  • GC0XM129705
  • GC0XM130465
  • GC0XM131485
  • GC0XM131587
  • GC0XM131760
  • GC0XM121164

Summaries for HS6ST2 Gene

Entrez Gene Summary for HS6ST2 Gene

  • Heparan sulfate proteoglycans are ubiquitous components of the cell surface, extracellular matrix, and basement membranes, and interact with various ligands to influence cell growth, differentiation, adhesion, and migration. This gene encodes a member of the heparan sulfate (HS) sulfotransferase gene family, which catalyze the transfer of sulfate to HS. Different family members and isoforms are thought to synthesize heparan sulfates with tissue-specific structures and functions. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for HS6ST2 Gene

HS6ST2 (Heparan Sulfate 6-O-Sulfotransferase 2) is a Protein Coding gene. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include sulfotransferase activity. An important paralog of this gene is HS6ST3.

UniProtKB/Swiss-Prot for HS6ST2 Gene

  • 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3-phosphoadenosine 5-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HS6ST2 Gene

Genomics for HS6ST2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HS6ST2 Gene

132,626,010 bp from pter
132,961,395 bp from pter
335,386 bases
Minus strand

Genomic View for HS6ST2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HS6ST2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HS6ST2 Gene

Proteins for HS6ST2 Gene

  • Protein details for HS6ST2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heparan-sulfate 6-O-sulfotransferase 2
    Protein Accession:
    Secondary Accessions:
    • B9WRT4
    • B9WRT5
    • E9PDY5
    • Q2TB13
    • Q4VC07
    • Q6PIC4
    • Q86SM9
    • Q8N3T4
    • Q8NBN4
    • Q96SJ4

    Protein attributes for HS6ST2 Gene

    605 amino acids
    Molecular mass:
    69130 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HS6ST2 Gene


neXtProt entry for HS6ST2 Gene

Proteomics data for HS6ST2 Gene at MOPED

Selected DME Specific Peptides for HS6ST2 Gene

Post-translational modifications for HS6ST2 Gene

  • Glycosylation at Asn209, Asn404, Asn460, Thr528, Asn544, Asn556, Asn564, Asn589, and Asn592
  • Modification sites at PhosphoSitePlus

Other Protein References for HS6ST2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for HS6ST2 (Heparan Sulfate 6-O-Sulfotransferase 2/HS6ST2)
  • Santa Cruz Biotechnology (SCBT) Antibodies for HS6ST2

Domains for HS6ST2 Gene

Gene Families for HS6ST2 Gene

Protein Domains for HS6ST2 Gene

Suggested Antigen Peptide Sequences for HS6ST2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sulfotransferase 6 family.
  • Belongs to the sulfotransferase 6 family.
genes like me logo Genes that share domains with HS6ST2: view

Function for HS6ST2 Gene

Molecular function for HS6ST2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3,5-bisphosphate + [heparan sulfate]-glucosamine 6-sulfate
UniProtKB/Swiss-Prot Function:
6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3-phosphoadenosine 5-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate

Enzyme Numbers (IUBMB) for HS6ST2 Gene

Gene Ontology (GO) - Molecular Function for HS6ST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008146 sulfotransferase activity --
GO:0017095 heparan sulfate 6-O-sulfotransferase activity IEA --
genes like me logo Genes that share ontologies with HS6ST2: view

Phenotypes for HS6ST2 Gene

genes like me logo Genes that share phenotypes with HS6ST2: view

Animal Models for HS6ST2 Gene

MGI Knock Outs for HS6ST2:

Animal Model Products

miRNA for HS6ST2 Gene

miRTarBase miRNAs that target HS6ST2

No data available for Transcription Factor Targeting and HOMER Transcription for HS6ST2 Gene

Localization for HS6ST2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HS6ST2 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for HS6ST2 Gene COMPARTMENTS Subcellular localization image for HS6ST2 gene
Compartment Confidence
golgi apparatus 4
nucleus 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HS6ST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005654 nucleoplasm IDA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with HS6ST2: view

Pathways for HS6ST2 Gene

genes like me logo Genes that share pathways with HS6ST2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Polycomb & Trithorax Target Genes in human,mouse,rat

Interacting Proteins for HS6ST2 Gene

Gene Ontology (GO) - Biological Process for HS6ST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006024 glycosaminoglycan biosynthetic process TAS --
GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification IEA --
GO:0030203 glycosaminoglycan metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with HS6ST2: view

Compounds for HS6ST2 Gene

(1) HMDB Compounds for HS6ST2 Gene

Compound Synonyms Cas Number PubMed IDs
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
genes like me logo Genes that share compounds with HS6ST2: view

Transcripts for HS6ST2 Gene

Unigene Clusters for HS6ST2 Gene

Heparan sulfate 6-O-sulfotransferase 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HS6ST2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HS6ST2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1: - -

Relevant External Links for HS6ST2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HS6ST2 Gene

mRNA expression in normal human tissues for HS6ST2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HS6ST2 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (6.6), Ovary (4.8), and Brain - Hypothalamus (4.6).

Protein differential expression in normal tissues for HS6ST2 Gene

This gene is overexpressed in Testis (37.3) and Ovary (31.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HS6ST2 Gene

SOURCE GeneReport for Unigene cluster for HS6ST2 Gene Hs.385956

genes like me logo Genes that share expressions with HS6ST2: view

Expression partners for HS6ST2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HS6ST2 Gene

Orthologs for HS6ST2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HS6ST2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HS6ST2 35
  • 92.18 (n)
  • 92.89 (a)
HS6ST3 36
  • 41 (a)
(Canis familiaris)
Mammalia HS6ST2 35
  • 94.21 (n)
  • 93.8 (a)
HS6ST2 36
  • 97 (a)
(Mus musculus)
Mammalia Hs6st2 35
  • 91.37 (n)
  • 91.47 (a)
Hs6st2 16
Hs6st2 36
  • 87 (a)
(Pan troglodytes)
Mammalia HS6ST2 35
  • 94.01 (n)
  • 93.41 (a)
HS6ST2 36
  • 93 (a)
(Rattus norvegicus)
Mammalia Hs6st2 35
  • 90.49 (n)
  • 90.85 (a)
(Monodelphis domestica)
Mammalia HS6ST2 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia HS6ST2 36
  • 85 (a)
(Gallus gallus)
Aves HS6ST2 35
  • 79.84 (n)
  • 87.17 (a)
HS6ST2 36
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hs6st2 35
  • 77.54 (n)
  • 87.63 (a)
(Danio rerio)
Actinopterygii hs6st2 35
  • 65.97 (n)
  • 70.08 (a)
CU929314.1 36
  • 74 (a)
hs6st2 36
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hs6st 36
  • 38 (a)
(Caenorhabditis elegans)
Secernentea hst-6 35
  • 51.88 (n)
  • 49.15 (a)
hst-6 36
  • 41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
Species with no ortholog for HS6ST2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HS6ST2 Gene

Gene Tree for HS6ST2 (if available)
Gene Tree for HS6ST2 (if available)

Paralogs for HS6ST2 Gene

Paralogs for HS6ST2 Gene

(2) SIMAP similar genes for HS6ST2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HS6ST2: view

Variants for HS6ST2 Gene

Sequence variations from dbSNP and Humsavar for HS6ST2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs592 -- 132,842,584(-) GAGAA(C/T)AGGCC intron-variant
rs2046 -- 132,874,095(-) GGGCA(A/C)GCCTG intron-variant
rs17379 -- 132,942,884(-) GGTAC(A/G)TACAC intron-variant
rs17380 -- 132,696,767(+) TTTTG(-/C)AAAAA intron-variant
rs17390 -- 132,776,183(+) TTGAT(C/T)GAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HS6ST2 Gene

Variant ID Type Subtype PubMed ID
nsv7093 CNV Insertion 18451855
esv267670 CNV Insertion 20981092
nsv7094 CNV Insertion 18451855
esv2670884 CNV Deletion 23128226
esv21961 CNV Loss 19812545
esv2657460 CNV Deletion 23128226
nsv7095 CNV Insertion 18451855
esv2740485 CNV Deletion 23290073
esv33324 CNV Loss 17666407
nsv7096 CNV Insertion 18451855

Relevant External Links for HS6ST2 Gene

HapMap Linkage Disequilibrium report
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HS6ST2 Gene

Disorders for HS6ST2 Gene

Relevant External Links for HS6ST2

Genetic Association Database (GAD)

No disorders were found for HS6ST2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for HS6ST2 Gene

Publications for HS6ST2 Gene

  1. The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine. (PMID: 10644753) Habuchi H. … Kimata K. (J. Biol. Chem. 2000) 2 3 23
  2. Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced forms of human heparan sulphate 6-O-sulphotransferase-2 having different expression patterns and properties. (PMID: 12492399) Habuchi H. … Kimata K. (Biochem. J. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4

Products for HS6ST2 Gene

Sources for HS6ST2 Gene

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