Aliases for HS6ST2 Gene
External Ids for HS6ST2 Gene
Previous GeneCards Identifiers for HS6ST2 Gene
Heparan sulfate proteoglycans are ubiquitous components of the cell surface, extracellular matrix, and basement membranes, and interact with various ligands to influence cell growth, differentiation, adhesion, and migration. This gene encodes a member of the heparan sulfate (HS) sulfotransferase gene family, which catalyze the transfer of sulfate to HS. Different family members and isoforms are thought to synthesize heparan sulfates with tissue-specific structures and functions. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for HS6ST2 Gene
HS6ST2 (Heparan Sulfate 6-O-Sulfotransferase 2) is a Protein Coding gene. Among its related pathways are heparan sulfate biosynthesis and Articular Cartilage Extracellular Matrix Pathway. GO annotations related to this gene include sulfotransferase activity and heparan sulfate 6-O-sulfotransferase activity. An important paralog of this gene is HS6ST3.
UniProtKB/Swiss-Prot for HS6ST2 Gene
6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3-phosphoadenosine 5-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.