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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HS6ST2 Gene

protein-coding GIFtS: 54
GCID: GC0XM131760

heparan sulfate 6-O-sulfotransferase 2

Explore 2 diseases affiliated with
HS6ST2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Heparan Sulfate 6-O-Sulfotransferase 2¹ ²
HS6ST-2² ³
Heparan-Sulfate 6-O-Sulfotransferase 2²
EC 2.8.2.-³
EC 2.8.2⁸

External Ids:	HGNC: 19133¹	Entrez Gene: 90161²	Ensembl: ENSG00000171004⁷	OMIM: 300545⁵	UniProtKB: Q96MM7³

Export aliases for HS6ST2 gene to outside databases

Previous GC identifers: GC0XM126407 GC0XM128605 GC0XM129705 GC0XM130465 GC0XM131485 GC0XM131587 GC0XM121164

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HS6ST2:

Heparan sulfate proteoglycans are ubiquitous components of the cell surface, extracellular matrix, and basement

membranes, and interact with various ligands to influence cell growth, differentiation, adhesion, and migration. This

gene encodes a member of the heparan sulfate (HS) sulfotransferase gene family, which catalyze the transfer of sulfate

to HS. Different family members and isoforms are thought to synthesize heparan sulfates with tissue-specific

structures and functions. Multiple transcript variants encoding different isoforms have been found for this gene.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: H6ST2_HUMAN, Q96MM7

Function: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate

(PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_011786.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HS6ST2 gene promoter:
GATA-3 POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) CUTL1 Nkx2-5 POU3F2 NF-kappaB NF-kappaB1 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HS6ST2 promoter sequence

Search SABiosciences Chromatin IP Primers for HS6ST2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HS6ST2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26.2 Ensembl cytogenetic band: Xq26.2 HGNC cytogenetic band: Xq26.2

HS6ST2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HS6ST2 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM131760: view genomic region (about GC identifiers)

Start:	131,760,038 bp from pter	End:	132,095,423 bp from pter
Size:	335,386 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: H6ST2_HUMAN, Q96MM7 (See protein sequence)

Recommended Name: Heparan-sulfate 6-O-sulfotransferase 2

Size: 605 amino acids; 69130 Da

Subcellular location: Membrane; Single-pass type II membrane protein (Potential)

Secondary accessions: B9WRT4 B9WRT5 Q2TB13 Q4VC07 Q6PIC4 Q86SM9 Q8N3T4 Q8NBN4 Q96SJ4

Alternative splicing: 3 isoforms: Q96MM7-1 Q96MM7-2 Q96MM7-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HS6ST2: NX_Q96MM7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96MM7

4/6 DME Specific Peptides for HS6ST2 (Q96MM7) (see all 6)

GQKKCTC

FISPFTQ

MAFFGLTE

LRDPVSRYLSEW

HS6ST2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001070656.1 NP_671704.3

ENSEMBL proteins:

ENSP00000359874 ENSP00000435108 ENSP00000359873 ENSP00000429473 ENSP00000359870

ENSP00000384013

Reactome Protein details: Q96MM7
Human Recombinant Protein Products for HS6ST2:

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	GenScript Custom Purified and Recombinant Proteins Services for HS6ST2
	Novus Biologicals HS6ST2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for HS6ST2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	TAS	--
GO:0016021	integral to membrane	IEA	--

HS6ST2 for ontologies About GeneDecksing

HS6ST2 Antibody Products:

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	Search ThermoFisher Antibodies for HS6ST2

Assay Products for HS6ST2:

	Browse Kits and Assays available from EMD Millipore
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	Uscn ELISAs and CLIAs for HS6ST2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HS6ST2 for domains About GeneDecksing

2 InterPro domains/families:

IPR010635 Heparan_SO4-6-sulfoTrfase

IPR005331 Sulfotransferase

Graphical View of Domain Structure for InterPro Entry Q96MM7

ProtoNet protein and cluster: Q96MM7

UniProtKB/Swiss-Prot: H6ST2_HUMAN, Q96MM7

Similarity: Belongs to the sulfotransferase 6 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: H6ST2_HUMAN, Q96MM7

Function: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate

(PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate

Catalytic activity: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate +

[heparan sulfate]-glucosamine 6-sulfate

Enzyme Numbers (IUBMB): EC 2.8.2.-¹ EC 2.8.2²

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008146	sulfotransferase activity	IEA	--

HS6ST2 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for HS6ST2:

Decreased viability with pacli

4 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Hs6st2):

cellular

endocrine/exocrine gland

no phenotypic analysis

normal

HS6ST2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Hs6st2^tm1Lex for HS6ST2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HS6ST2

miRNA Products:		OriGene 3'-UTR Clone (see all 2): HS6ST2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HS6ST2
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate HS6ST2 (see all 9):
		hsa-miR-140-3p hsa-miR-582-5p hsa-miR-3673 hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-23c hsa-miR-488

		SwitchGear 3'UTR luciferase reporter plasmid: HS6ST2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HS6ST2 (see all 4) OriGene shRNA RFP: HS6ST2 Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HS6ST2
		Sirion Biotech Custom design and validation of potent shRNA sequences against HS6ST2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for HS6ST2
			Sirion Biotech Customized adenovirus for overexpression of HS6ST2 Sirion Biotech Customized adenovirus for potent knockdown of HS6ST2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HS6ST2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HS6ST2 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): HS6ST2 (NM_147175)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HS6ST2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HS6ST2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HS6ST2
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		Sirion Biotech Customized stable knockdown cell line services for HS6ST2 Sirion Biotech Customized inducible knockdown cell line services for HS6ST2 Sirion Biotech Customized stable overexpressing cell line services for HS6ST2 Sirion Biotech Customized inducible overexpressing cell line services for HS6ST2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HS6ST2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

MPS IIIC - Sanfilippo syndrome C

8/16 pathways (see all 16)
MPS VI - Maroteaux-Lamy syndrome	1.00	MPS IIIA - Sanfilippo syndrome A	1.00
MPS IIIC - Sanfilippo syndrome C	1.00	MPS IIID - Sanfilippo syndrome D	1.00
MPS I - Hurler syndrome	1.00	MPS IX - Natowicz syndrome	1.00
Mucopolysaccharidoses	1.00	MPS II - Hunter syndrome	1.00

heparan sulfate biosynthesis

	heparan sulfate biosynthesis	1.00			heparan sulfate biosynthesis (late stages)	0.78
	Glycosaminoglycan biosynthesis - heparan sulfate	0.83

Disease

Disease

1.00

Metabolism

Metabolism

1.00

Articular Cartilage Extracellular Matrix

Articular Cartilage Extracellular Matrix

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 R&D Systems Pathway for HS6ST2

Articular Cartilage Extracellular Matrix

3 BioSystems Pathways for HS6ST2

	heparan sulfate biosynthesis (late stages)
	heparan sulfate biosynthesis
	metapathway biotransformation

5/18 Reactome Pathways for HS6ST2 (see all 18)

	MPS VI - Maroteaux-Lamy syndrome
	Metabolism
	Disease
	HS-GAG biosynthesis
	MPS II - Hunter syndrome

1 Kegg Pathway (Kegg details for HS6ST2):

Glycosaminoglycan biosynthesis - heparan sulfate

HS6ST2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for HS6ST2

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	TAS	--
GO:0006024	glycosaminoglycan biosynthetic process	TAS	--
GO:0030203	glycosaminoglycan metabolic process	TAS	--
GO:0044281	small molecule metabolic process	TAS	--

HS6ST2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HS6ST2

1 HMDB Compound for HS6ST2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Phosphoadenosine phosphosulfate	3'-Phospho-5'-adenylyl sulfate (see all 9)	482-67-7	--

Search CenterWatch for drugs/clinical trials and news about HS6ST2 / H6ST2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HS6ST2 gene (2 alternative transcripts):

NM_001077188.1 NM_147175.3

Unigene Cluster for HS6ST2:

Heparan sulfate 6-O-sulfotransferase 2

Hs.385956 [show with all ESTs]

Unigene Representative Sequence: NM_001077188

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000370837(uc011mva.1 uc011mvb.1 uc011mvc.1) ENST00000461959

ENST00000370836(uc011mvd.1 uc011mve.1) ENST00000521489 ENST00000370833

ENST00000406696

miRNA Products:		OriGene 3'-UTR Clone (see all 2): HS6ST2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HS6ST2
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate HS6ST2 (see all 9):
		hsa-miR-140-3p hsa-miR-582-5p hsa-miR-3673 hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-23c hsa-miR-488

		SwitchGear 3'UTR luciferase reporter plasmid: HS6ST2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HS6ST2 (see all 4) OriGene shRNA RFP: HS6ST2 Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HS6ST2
		Sirion Biotech Custom design and validation of potent shRNA sequences against HS6ST2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HS6ST2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HS6ST2 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): HS6ST2 (NM_147175)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HS6ST2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HS6ST2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HS6ST2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HS6ST2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HS6ST2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HS6ST2

Additional cDNA sequence:

AB067776.1 AB067777.1 AK027720.1 AK056706.1 AK075402.1 AK295041.1 AK295118.1 AK298956.1

AL049679.1 AL831923.1 BC037325.2 BC094718.1 BC110620.1 BC110621.1

8 DOTS entries:

DT.308830 DT.100021671 DT.102822215 DT.97835586 DT.102822218 DT.121308823 DT.121308835 DT.91992605

16 AceView cDNA sequences:

CD637446 BP873480 CF593799 CD637461 CD637453 CD637459 CD637456 BM903622

CD637444 CD637443 CD637450 CD637448 CD637449 CD637458 CD637462 CD637451

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for HS6ST2 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b
SP1:							-		-
SP2:

ECgene alternative splicing isoforms for HS6ST2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HS6ST2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTAGTTTTA

About this image

HS6ST2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

5 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Brain

Brain

Neural Tube

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

Epiblast-like cells (Reconstitution of mo...)

See HS6ST2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HS6ST2

SOURCE GeneReport for Unigene cluster: Hs.385956

SABiosciences Expression via Pathway-Focused PCR Array including HS6ST2:

Polycomb & Trithorax Target Genes in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HS6ST2 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HS6ST2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HS6ST2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for HS6ST2 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Hs6st2^{1 , 5}	heparan sulfate 6-O-sulfotransferase 2^{1, 5}	91.42(n)¹ 91.63(a)¹		X (28.04 cM)⁵ 50786¹ NM_001077202.1¹ NP_001070670.1¹ 51387212⁵
chicken (Gallus gallus)	Aves	HS6ST2¹	heparan sulfate 6-O-sulfotransferase 2	79.15(n) 86.15(a)		395150 NM_204490.1 NP_989821.1
zebrafish (Danio rerio)	Actinopterygii	hs6st2¹	heparan sulfate 6-O-sulfotransferase 2	61.43(n) 61.95(a)		378450 NM_194421.1 NP_919402.1
fruit fly (Drosophila melanogaster)	Insecta	Hs6st⁶	Heparan sulfate 6-O-sulfotransferase	37(a)	1 → many	3R(15755436-15834244)
worm (Caenorhabditis elegans)	Secernentea	hst-6¹	Protein HST-6	51.76(n) 49.15(a)		189586 NM_076494.2 NP_508895.2

ENSEMBL Gene Tree for HS6ST2 (if available)
TreeFam Gene Tree for HS6ST2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HS6ST2 gene

HS6ST3² HS6ST1²

2 SIMAP similar genes for HS6ST2 using alignment to 4 protein entries: H6ST2_HUMAN (see all proteins):

HS6ST3 HS6ST1

HS6ST2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs5975346^1,2	C,H	--	131759569(+)	`AGTTTA/CCAGGC`	2	--	ds500¹		6		NS EA NA	422
rs185962107^1,2		--	131759611(+)	`TTGTAG/TCTTTC`	2	--	ds500¹		0	--	--	--	--
rs191255149^1,2		--	131759663(+)	`AAAAGC/TGCAAG`	2	--	ds500¹		0	--	--	--	--
rs181252227^1,2		--	131759815(+)	`AAGAGC/TACCAT`	2	--	ds500¹		0	--	--	--	--
rs186759853^1,2		--	131759900(+)	`TGAGGA/GATTAG`	2	--	ds500¹		0	--	--	--	--
rs190424657^1,2		--	131760141(+)	`GAAATA/CATGGG`	2	--	ut3¹		0	--	--	--	--
rs36208458^1,2	C	--	131760165(+)	`CAAAA-/ATGTAT ATGTA`	2	--	ut3¹		0	--	--	--	--
rs34948227^1,2	C,F	--	131760197(+)	`TATATC/ACAATA`	2	--	ut3¹		2		NA	4
rs183011584^1,2		--	131760252(+)	`CACACC/GACAGC`	2	--	ut3¹		0	--	--	--	--
rs148751513^1,2		--	131760299(+)	`CACTGG/TCTCAG`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for HS6ST2 (131760038 - 132010038 bp, first 250kb of HS6ST2)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for HS6ST2
1 CNV: 68035
4 Indels: 11354 96978 83752 96977
Locus Specific Mutation Databases (LSDB): HS6ST2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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HS6ST2 for disorders           About GeneDecksing

OMIM gene information: 300545    OMIM disorders: --

2 diseases for HS6ST2:    About MalaCards

pancreatitis neuronitis

Export disorders for HS6ST2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for HS6ST2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with HS6ST2)

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The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine. (PubMed id 10644753)^{1, 3, 9} Habuchi H....Kimata K. (2000)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (2005)
Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)^{1, 2} Otsuki T....Isogai T. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced forms of human heparan sulphate 6-O-sulphotransferase-2 having different expression patterns and properties. (PubMed id 12492399)^{1, 2} Habuchi H.... Kimata K. (2003)
Silencing of hHS6ST2 inhibits progression of pancreat ic cancer through inhibition of Notch signalling. (PubMed id 21443520)¹ Song K....Li P. (2011)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Distinctive expression patterns of heparan sulfate O-sulfotransferases and regional differences in heparan sulfate structure in chick limb buds. (PubMed id 14660620)⁹ Nogami K....Kimata K. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 90161	HGNC: 19133	AceView: HS6ST2.1	Ensembl:ENSG00000171004	euGenes: HUgn90161
ECgene: HS6ST2	Kegg: 90161	H-InvDB: HS6ST2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for HS6ST2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for HS6ST2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for HS6ST2 gene:
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GeneCards and IP:
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heparan sulfate 6-O-sulfotransferase 2

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HS6ST2 Gene

heparan sulfate 6-O-sulfotransferase 2

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