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Aliases for HS6ST2 Gene

Aliases for HS6ST2 Gene

  • Heparan Sulfate 6-O-Sulfotransferase 2 2 3 5
  • HS6ST-2 3 4
  • EC 2.8.2.- 4
  • EC 2.8.2 63

External Ids for HS6ST2 Gene

Previous GeneCards Identifiers for HS6ST2 Gene

  • GC0XM126407
  • GC0XM128605
  • GC0XM129705
  • GC0XM130465
  • GC0XM131485
  • GC0XM131587
  • GC0XM131760
  • GC0XM121164

Summaries for HS6ST2 Gene

Entrez Gene Summary for HS6ST2 Gene

  • Heparan sulfate proteoglycans are ubiquitous components of the cell surface, extracellular matrix, and basement membranes, and interact with various ligands to influence cell growth, differentiation, adhesion, and migration. This gene encodes a member of the heparan sulfate (HS) sulfotransferase gene family, which catalyze the transfer of sulfate to HS. Different family members and isoforms are thought to synthesize heparan sulfates with tissue-specific structures and functions. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for HS6ST2 Gene

HS6ST2 (Heparan Sulfate 6-O-Sulfotransferase 2) is a Protein Coding gene. Among its related pathways are heparan sulfate biosynthesis and Glycosaminoglycan metabolism. GO annotations related to this gene include sulfotransferase activity and heparan sulfate 6-O-sulfotransferase activity. An important paralog of this gene is HS6ST3.

UniProtKB/Swiss-Prot for HS6ST2 Gene

  • 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3-phosphoadenosine 5-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HS6ST2 Gene

Genomics for HS6ST2 Gene

Regulatory Elements for HS6ST2 Gene

Enhancers for HS6ST2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HS6ST2 on UCSC Golden Path with GeneCards custom track

Genomic Location for HS6ST2 Gene

132,626,010 bp from pter
132,961,395 bp from pter
335,386 bases
Minus strand

Genomic View for HS6ST2 Gene

Genes around HS6ST2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HS6ST2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HS6ST2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HS6ST2 Gene

Proteins for HS6ST2 Gene

  • Protein details for HS6ST2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heparan-sulfate 6-O-sulfotransferase 2
    Protein Accession:
    Secondary Accessions:
    • B9WRT4
    • B9WRT5
    • E9PDY5
    • Q2TB13
    • Q4VC07
    • Q6PIC4
    • Q86SM9
    • Q8N3T4
    • Q8NBN4
    • Q96SJ4

    Protein attributes for HS6ST2 Gene

    605 amino acids
    Molecular mass:
    69130 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HS6ST2 Gene


neXtProt entry for HS6ST2 Gene

Proteomics data for HS6ST2 Gene at MOPED

Selected DME Specific Peptides for HS6ST2 Gene

Post-translational modifications for HS6ST2 Gene

  • Glycosylation at Asn 209, Asn 404, Asn 460, Thr 528, Asn 544, Asn 556, Asn 564, Asn 589, and Asn 592
  • Modification sites at PhosphoSitePlus

Other Protein References for HS6ST2 Gene

Antibody Products

  • R&D Systems Antibodies for HS6ST2 (Heparan Sulfate 6-O-Sulfotransferase 2/HS6ST2)
  • Santa Cruz Biotechnology (SCBT) Antibodies for HS6ST2

Domains & Families for HS6ST2 Gene

Gene Families for HS6ST2 Gene

Protein Domains for HS6ST2 Gene

Suggested Antigen Peptide Sequences for HS6ST2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sulfotransferase 6 family.
  • Belongs to the sulfotransferase 6 family.
genes like me logo Genes that share domains with HS6ST2: view

Function for HS6ST2 Gene

Molecular function for HS6ST2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3,5-bisphosphate + [heparan sulfate]-glucosamine 6-sulfate.
UniProtKB/Swiss-Prot Function:
6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3-phosphoadenosine 5-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.

Enzyme Numbers (IUBMB) for HS6ST2 Gene

genes like me logo Genes that share phenotypes with HS6ST2: view

Animal Models for HS6ST2 Gene

MGI Knock Outs for HS6ST2:

Animal Model Products

  • Taconic Biosciences Mouse Models for HS6ST2

miRNA for HS6ST2 Gene

miRTarBase miRNAs that target HS6ST2

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HS6ST2 Gene

Localization for HS6ST2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HS6ST2 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for HS6ST2 Gene COMPARTMENTS Subcellular localization image for HS6ST2 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
nucleus 5
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HS6ST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with HS6ST2: view

Pathways & Interactions for HS6ST2 Gene

genes like me logo Genes that share pathways with HS6ST2: view

Interacting Proteins for HS6ST2 Gene

Gene Ontology (GO) - Biological Process for HS6ST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification IBA --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with HS6ST2: view

No data available for SIGNOR curated interactions for HS6ST2 Gene

Drugs & Compounds for HS6ST2 Gene

(2) Additional Compounds for HS6ST2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
genes like me logo Genes that share compounds with HS6ST2: view

Transcripts for HS6ST2 Gene

Unigene Clusters for HS6ST2 Gene

Heparan sulfate 6-O-sulfotransferase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HS6ST2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1: - -

Relevant External Links for HS6ST2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HS6ST2 Gene

mRNA expression in normal human tissues for HS6ST2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HS6ST2 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x6.6), Ovary (x4.8), and Brain - Hypothalamus (x4.6).

Protein differential expression in normal tissues from HIPED for HS6ST2 Gene

This gene is overexpressed in Testis (37.3) and Ovary (31.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HS6ST2 Gene

SOURCE GeneReport for Unigene cluster for HS6ST2 Gene Hs.385956

genes like me logo Genes that share expression patterns with HS6ST2: view

Protein tissue co-expression partners for HS6ST2 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for HS6ST2 Gene

Orthologs for HS6ST2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HS6ST2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HS6ST2 35
  • 92.18 (n)
  • 92.89 (a)
HS6ST3 36
  • 41 (a)
(Canis familiaris)
Mammalia HS6ST2 35
  • 94.21 (n)
  • 93.8 (a)
HS6ST2 36
  • 97 (a)
(Mus musculus)
Mammalia Hs6st2 35
  • 91.37 (n)
  • 91.47 (a)
Hs6st2 16
Hs6st2 36
  • 87 (a)
(Pan troglodytes)
Mammalia HS6ST2 35
  • 94.01 (n)
  • 93.41 (a)
HS6ST2 36
  • 93 (a)
(Rattus norvegicus)
Mammalia Hs6st2 35
  • 90.49 (n)
  • 90.85 (a)
(Monodelphis domestica)
Mammalia HS6ST2 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia HS6ST2 36
  • 85 (a)
(Gallus gallus)
Aves HS6ST2 35
  • 79.84 (n)
  • 87.17 (a)
HS6ST2 36
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hs6st2 35
  • 77.54 (n)
  • 87.63 (a)
(Danio rerio)
Actinopterygii hs6st2 35
  • 65.97 (n)
  • 70.08 (a)
CU929314.1 36
  • 74 (a)
hs6st2 36
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hs6st 36
  • 38 (a)
(Caenorhabditis elegans)
Secernentea hst-6 35
  • 51.88 (n)
  • 49.15 (a)
hst-6 36
  • 41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
Species with no ortholog for HS6ST2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HS6ST2 Gene

Gene Tree for HS6ST2 (if available)
Gene Tree for HS6ST2 (if available)

Paralogs for HS6ST2 Gene

Paralogs for HS6ST2 Gene

(2) SIMAP similar genes for HS6ST2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HS6ST2: view

Variants for HS6ST2 Gene

Sequence variations from dbSNP and Humsavar for HS6ST2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs7053397 - 132,958,222(+) ACGTG(C/G)TTCAG upstream-variant-2KB, reference, missense
rs747689750 -- 132,906,607(+) GATCC(C/T)TCGTG intron-variant
rs747691498 -- 132,769,180(+) TCTAC(C/G)GTGCT intron-variant
rs747692210 -- 132,843,067(+) TTATC(G/T)CCACC intron-variant
rs747697533 -- 132,813,042(+) CTGTC(A/T)TCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HS6ST2 Gene

Variant ID Type Subtype PubMed ID
nsv7093 CNV Insertion 18451855
esv267670 CNV Insertion 20981092
nsv7094 CNV Insertion 18451855
esv2670884 CNV Deletion 23128226
esv21961 CNV Loss 19812545
esv2657460 CNV Deletion 23128226
nsv7095 CNV Insertion 18451855
esv2740485 CNV Deletion 23290073
esv33324 CNV Loss 17666407
nsv7096 CNV Insertion 18451855

Variation tolerance for HS6ST2 Gene

Residual Variation Intolerance Score: 79.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.28; 40.90% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HS6ST2 Gene

Disorders for HS6ST2 Gene

Relevant External Links for HS6ST2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HS6ST2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HS6ST2 Gene

Publications for HS6ST2 Gene

  1. The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine. (PMID: 10644753) Habuchi H. … Kimata K. (J. Biol. Chem. 2000) 2 3 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. Ovarian cancer cell heparan sulfate 6-O-sulfotransferases regulate an angiogenic program induced by heparin-binding epidermal growth factor (EGF)-like growth factor/EGF receptor signaling. (PMID: 24563483) Cole C.L. … Avizienyte E. (J. Biol. Chem. 2014) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for HS6ST2 Gene

Sources for HS6ST2 Gene