Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HS3ST6 Gene

Aliases for HS3ST6 Gene

  • Heparan Sulfate-Glucosamine 3-Sulfotransferase 6 2 3 5
  • Heparan Sulfate D-Glucosaminyl 3-O-Sulfotransferase 6 3 4
  • Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 5 2 3
  • Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 6 2 3
  • 3-OST-6 3 4
  • HS3ST5 3 4
  • Heparan Sulphate D-Glucosaminyl 3-O-Sulfotransferase-3B Like 3
  • Heparan Sulfate Glucosamine 3-O-Sulfotransferase 6 3
  • Heparan Sulfate 3-O-Sulfotransferase 6 4
  • EC 2.8.2.23 4
  • H3-OST-6 4
  • EC 2.8.2 56

External Ids for HS3ST6 Gene

Previous HGNC Symbols for HS3ST6 Gene

  • HS3ST5

Previous GeneCards Identifiers for HS3ST6 Gene

  • GC16U900028
  • GC16M001903
  • GC16M001905
  • GC16M001907
  • GC16M001961

Summaries for HS3ST6 Gene

GeneCards Summary for HS3ST6 Gene

HS3ST6 (Heparan Sulfate-Glucosamine 3-Sulfotransferase 6) is a Protein Coding gene. Among its related pathways are Glycosaminoglycan metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. An important paralog of this gene is HS3ST3B1.

UniProtKB/Swiss-Prot for HS3ST6 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to heparan sulfate. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes Simplex Virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.

Additional gene information for HS3ST6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HS3ST6 Gene

Genomics for HS3ST6 Gene

GeneHancer (GH) Regulatory Elements for HS3ST6 Gene

Promoters and enhancers for HS3ST6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I001920 Enhancer 0.7 ENCODE 550.8 +0.4 367 0.2 ESRRA KLF17 ZNF335 ZFHX2 CTBP1 ZNF143 ZNF600 EZH2 SP3 MAZ HS3ST6 HAGH PIR49138
GH16I001918 Promoter 0.6 EPDnew 550.8 +3.0 2987 0.1 POLR2A HS3ST6 PIR49138
GH16I001871 Promoter/Enhancer 1.3 EPDnew Ensembl 12.6 +49.1 49131 1 HDAC1 PKNOX1 ATF1 RB1 ZBTB40 POLR2B EGR1 ATF7 CREM SMAD5 LOC102723890 MEIOB FAHD1 HAGH HS3ST6 RAB26 SNORD60 TRAF7 JPT2 LINC00254
GH16I001870 Enhancer 0.8 ENCODE 12.6 +50.7 50668 0.9 FOXA2 KLF17 SIN3A ZSCAN9 RAD21 RARA YY1 ZSCAN5C FOS RXRA LOC102723890 FAHD1 HAGH HS3ST6 SNORD60 TRAF7 RAB26 JPT2 MEIOB GC16M001851
GH16I001839 Enhancer 0.8 ENCODE 12 +81.6 81599 0.7 HDGF KLF17 MZF1 ZNF76 ZNF335 SCRT2 SP3 ZNF398 ZEB2 ZFP69B PIR46763 FAHD1 HS3ST6 MEIOB CRAMP1 TELO2 IFT140 ENSG00000261505 TSR3 GNPTG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HS3ST6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HS3ST6 gene promoter:

Genomic Locations for HS3ST6 Gene

Genomic Locations for HS3ST6 Gene
chr16:1,911,463-1,921,422
(GRCh38/hg38)
Size:
9,960 bases
Orientation:
Minus strand
chr16:1,961,464-1,968,441
(GRCh37/hg19)

Genomic View for HS3ST6 Gene

Genes around HS3ST6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HS3ST6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HS3ST6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HS3ST6 Gene

Proteins for HS3ST6 Gene

  • Protein details for HS3ST6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QI5-HS3S6_HUMAN
    Recommended name:
    Heparan sulfate glucosamine 3-O-sulfotransferase 6
    Protein Accession:
    Q96QI5
    Secondary Accessions:
    • Q96RX7

    Protein attributes for HS3ST6 Gene

    Size:
    342 amino acids
    Molecular mass:
    37186 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK61299.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAC42157.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for HS3ST6 Gene

Selected DME Specific Peptides for HS3ST6 Gene

Q96QI5:
  • KGGTRALLE
  • WYRSLMPRTL
  • EPHFFDR
  • PRCLGKSKGR
  • EKTPSYFVT
  • PQALIVGVKKGGTRA
  • TKGFPCLKK

Post-translational modifications for HS3ST6 Gene

Other Protein References for HS3ST6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for HS3ST6 Gene

Gene Families for HS3ST6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for HS3ST6 Gene

Suggested Antigen Peptide Sequences for HS3ST6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96QI5

UniProtKB/Swiss-Prot:

HS3S6_HUMAN :
  • Belongs to the sulfotransferase 1 family.
Family:
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with HS3ST6: view

Function for HS3ST6 Gene

Molecular function for HS3ST6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3,5-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate.
UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to heparan sulfate. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes Simplex Virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.

Enzyme Numbers (IUBMB) for HS3ST6 Gene

Phenotypes From GWAS Catalog for HS3ST6 Gene

Gene Ontology (GO) - Molecular Function for HS3ST6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008146 sulfotransferase activity IEA --
GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity TAS --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with HS3ST6: view
genes like me logo Genes that share phenotypes with HS3ST6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HS3ST6 Gene

Localization for HS3ST6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HS3ST6 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HS3ST6 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
plasma membrane 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for HS3ST6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HS3ST6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HS3ST6 Gene

Pathways & Interactions for HS3ST6 Gene

genes like me logo Genes that share pathways with HS3ST6: view

Pathways by source for HS3ST6 Gene

Interacting Proteins for HS3ST6 Gene

Selected Interacting proteins: Q96QI5-HS3S6_HUMAN for HS3ST6 Gene via IID

Gene Ontology (GO) - Biological Process for HS3ST6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006024 glycosaminoglycan biosynthetic process TAS --
genes like me logo Genes that share ontologies with HS3ST6: view

No data available for SIGNOR curated interactions for HS3ST6 Gene

Drugs & Compounds for HS3ST6 Gene

(2) Additional Compounds for HS3ST6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
1053-73-2
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
482-67-7
genes like me logo Genes that share compounds with HS3ST6: view

Transcripts for HS3ST6 Gene

mRNA/cDNA for HS3ST6 Gene

(3) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HS3ST6 Gene

Heparan sulfate (glucosamine) 3-O-sulfotransferase 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for HS3ST6 Gene

No ASD Table

Relevant External Links for HS3ST6 Gene

GeneLoc Exon Structure for
HS3ST6
ECgene alternative splicing isoforms for
HS3ST6

Expression for HS3ST6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HS3ST6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HS3ST6 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x21.2), Skin - Not Sun Exposed (Suprapubic) (x18.5), and Esophagus - Mucosa (x4.2).

Protein differential expression in normal tissues from HIPED for HS3ST6 Gene

This gene is overexpressed in Pancreatic juice (33.3), Heart (13.7), Adipocyte (9.0), and Platelet (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HS3ST6 Gene



Protein tissue co-expression partners for HS3ST6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HS3ST6 Gene:

HS3ST6

SOURCE GeneReport for Unigene cluster for HS3ST6 Gene:

Hs.670144
genes like me logo Genes that share expression patterns with HS3ST6: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HS3ST6 Gene

Orthologs for HS3ST6 Gene

This gene was present in the common ancestor of animals.

Orthologs for HS3ST6 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia HS3ST6 34
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HS3ST6 33 34
  • 90.22 (n)
rat
(Rattus norvegicus)
Mammalia Hs3st6 33
  • 85.38 (n)
mouse
(Mus musculus)
Mammalia Hs3st6 33 16 34
  • 85.05 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HS3ST6 34
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HS3ST6 34
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HS3ST6 34
  • 24 (a)
OneToOne
chicken
(Gallus gallus)
Aves HS3ST6 33
  • 78.85 (n)
-- 34
  • 36 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 36 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489739 33
  • 71.74 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-121b10.7 33
  • 70.71 (n)
HS3ST6 34
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Hs3st-B 34
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea hst-3.2 34
  • 44 (a)
OneToOne
Species where no ortholog for HS3ST6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HS3ST6 Gene

ENSEMBL:
Gene Tree for HS3ST6 (if available)
TreeFam:
Gene Tree for HS3ST6 (if available)

Paralogs for HS3ST6 Gene

(6) SIMAP similar genes for HS3ST6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HS3ST6: view

Variants for HS3ST6 Gene

Sequence variations from dbSNP and Humsavar for HS3ST6 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000371419 -- 1,919,394(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000523707 -- 1,921,382(-) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant
rs1000627556 -- 1,915,776(-) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000680068 -- 1,915,926(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000742247 -- 1,913,872(-) G/A 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HS3ST6 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV duplication 17116639
esv3378138 CNV insertion 20981092
esv3387993 CNV insertion 20981092
nsv103288 CNV insertion 16902084
nsv519366 CNV loss 19592680
nsv833119 CNV loss 17160897
nsv833120 CNV loss 17160897
nsv952901 CNV deletion 24416366

Variation tolerance for HS3ST6 Gene

Residual Variation Intolerance Score: 95.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.24; 98.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HS3ST6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HS3ST6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HS3ST6 Gene

Disorders for HS3ST6 Gene

Additional Disease Information for HS3ST6

No disorders were found for HS3ST6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HS3ST6 Gene

Publications for HS3ST6 Gene

  1. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels RJ … Higgs DR (Human molecular genetics 2001) 2 3 4 58
  2. Characterization of heparan sulphate 3-O-sulphotransferase isoform 6 and its role in assisting the entry of herpes simplex virus type 1. (PMID: 15303968) Xu D … Liu J (The Biochemical journal 2005) 3 4 58
  3. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 3 4 58
  4. Characterization of a heparan sulfate 3-O-sulfotransferase-5, an enzyme synthesizing a tetrasulfated disaccharide. (PMID: 12740361) Mochizuki H … Narimatsu H (The Journal of biological chemistry 2003) 3 58
  5. Biosynthesis of 3-O-sulfated heparan sulfate: unique substrate specificity of heparan sulfate 3-O-sulfotransferase isoform 5. (PMID: 12907690) Chen J … Liu J (Glycobiology 2003) 3 58

Products for HS3ST6 Gene

Sources for HS3ST6 Gene

Content
Loading form....