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Aliases for HS3ST6 Gene

Aliases for HS3ST6 Gene

  • Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 6 2 3
  • Heparan Sulfate D-Glucosaminyl 3-O-Sulfotransferase 6 3 4
  • Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 5 2 3
  • H3-OST-6 3 4
  • 3-OST-6 3 4
  • HS3ST5 3 4
  • Heparan Sulphate D-Glucosaminyl 3-O-Sulfotransferase-3B Like 3
  • Heparan Sulfate Glucosamine 3-O-Sulfotransferase 6 3
  • Heparan Sulfate 3-O-Sulfotransferase 6 4
  • EC 2.8.2.23 4
  • EC 2.8.2 64

External Ids for HS3ST6 Gene

Previous Symbols for HS3ST6 Gene

  • HS3ST5

Summaries for HS3ST6 Gene

GeneCards Summary for HS3ST6 Gene

HS3ST6 (Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 6) is a Protein Coding gene. Diseases associated with HS3ST6 include mucopolysaccharidoses. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. An important paralog of this gene is NDST4.

UniProtKB/Swiss-Prot for HS3ST6 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to heparan sulfate. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes Simplex Virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HS3ST6 Gene

Genomics for HS3ST6 Gene

Genomic Location for HS3ST6 Gene

Start:
1,911,463 bp from pter
End:
1,918,440 bp from pter
Size:
6,978 bases
Orientation:
Minus strand

Genomic View for HS3ST6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HS3ST6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HS3ST6 Gene

Regulatory Elements for HS3ST6 Gene

Proteins for HS3ST6 Gene

  • Protein details for HS3ST6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QI5-HS3S6_HUMAN
    Recommended name:
    Heparan sulfate glucosamine 3-O-sulfotransferase 6
    Protein Accession:
    Q96QI5
    Secondary Accessions:
    • Q96RX7

    Protein attributes for HS3ST6 Gene

    Size:
    342 amino acids
    Molecular mass:
    37186 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK61299.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAC42157.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for HS3ST6 Gene

Proteomics data for HS3ST6 Gene at MOPED

Selected DME Specific Peptides for HS3ST6 Gene

Post-translational modifications for HS3ST6 Gene

Other Protein References for HS3ST6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for HS3ST6 Gene

Gene Families for HS3ST6 Gene

HGNC:
  • SULTM :Sulfotransferases, membrane-bound

Protein Domains for HS3ST6 Gene

UniProtKB/Swiss-Prot:

HS3S6_HUMAN
Family:
  • Belongs to the sulfotransferase 1 family.:
    • Q96QI5
genes like me logo Genes that share domains with HS3ST6: view

Function for HS3ST6 Gene

Molecular function for HS3ST6 Gene

UniProtKB/Swiss-Prot CatalyticActivity: 3-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3,5-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate
UniProtKB/Swiss-Prot Function: Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to heparan sulfate. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes Simplex Virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.

Enzyme Numbers (IUBMB) for HS3ST6 Gene

Gene Ontology (GO) - Molecular Function for HS3ST6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008146 sulfotransferase activity --
GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity ISS --
genes like me logo Genes that share ontologies with HS3ST6: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HS3ST6 Gene

Localization for HS3ST6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HS3ST6 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HS3ST6 Gene COMPARTMENTS Subcellular localization image for HS3ST6 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HS3ST6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HS3ST6: view

Pathways for HS3ST6 Gene

genes like me logo Genes that share pathways with HS3ST6: view

Interacting Proteins for HS3ST6 Gene

Gene Ontology (GO) - Biological Process for HS3ST6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006024 glycosaminoglycan biosynthetic process TAS --
GO:0008152 metabolic process --
GO:0030203 glycosaminoglycan metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with HS3ST6: view

Transcripts for HS3ST6 Gene

mRNA/cDNA for HS3ST6 Gene

(5) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HS3ST6 Gene

Heparan sulfate (glucosamine) 3-O-sulfotransferase 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HS3ST6 Gene

No ASD Table

Relevant External Links for HS3ST6 Gene

GeneLoc Exon Structure for
HS3ST6
ECgene alternative splicing isoforms for
HS3ST6

Expression for HS3ST6 Gene

mRNA expression in normal human tissues for HS3ST6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HS3ST6 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (21.2), Skin - Not Sun Exposed (Suprapubic) (18.5), and Esophagus - Mucosa (4.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for HS3ST6 Gene

SOURCE GeneReport for Unigene cluster for HS3ST6 Gene Hs.670144

genes like me logo Genes that share expressions with HS3ST6: view

Orthologs for HS3ST6 Gene

This gene was present in the common ancestor of animals.

Orthologs for HS3ST6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HS3ST6 37
  • 71 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HS3ST6 36
  • 90.22 (n)
  • 88.71 (a)
HS3ST6 37
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HS3ST6 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hs3st6 36
  • 85.05 (n)
  • 90.97 (a)
Hs3st6 16
Hs3st6 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HS3ST6 37
  • 24 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HS3ST6 37
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hs3st6 36
  • 85.38 (n)
  • 91.29 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 36 (a)
ManyToMany
HS3ST6 36
  • 78.85 (n)
  • 81.54 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 36 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489739 36
  • 71.74 (n)
  • 80.86 (a)
zebrafish
(Danio rerio)
Actinopterygii HS3ST6 37
  • 56 (a)
OneToOne
si:dkey-121b10.7 36
  • 70.71 (n)
  • 73.48 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hs3st-B 37
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea hst-3.2 37
  • 44 (a)
OneToOne
Species with no ortholog for HS3ST6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HS3ST6 Gene

ENSEMBL:
Gene Tree for HS3ST6 (if available)
TreeFam:
Gene Tree for HS3ST6 (if available)

Paralogs for HS3ST6 Gene

Selected SIMAP similar genes for HS3ST6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HS3ST6: view

Variants for HS3ST6 Gene

Sequence variations from dbSNP and Humsavar for HS3ST6 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs337285 -- 1,911,673(+) GACCA(C/G)GGCCT reference, missense
rs337286 -- 1,915,718(+) GGGAA(C/T)GGCTG intron-variant
rs337287 -- 1,915,861(+) ACTGC(C/G)GAGGC intron-variant
rs337288 -- 1,917,747(+) AGCCG(C/G)GACCC intron-variant
rs740466 -- 1,919,082(+) ATAGG(C/T)TTCCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HS3ST6 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
dgv2540n71 CNV Loss 21882294
nsv833119 CNV Loss 17160897
nsv519366 CNV Loss 19592680
dgv2544n71 CNV Loss 21882294
dgv2545n71 CNV Loss 21882294
nsv833120 CNV Loss 17160897
nsv905048 CNV Loss 21882294
nsv905053 CNV Gain 21882294
nsv103288 CNV Insertion 16902084

Relevant External Links for HS3ST6 Gene

HapMap Linkage Disequilibrium report
HS3ST6

Disorders for HS3ST6 Gene

(1) MalaCards Diseases for HS3ST6 Gene

Search for HS3ST6 Gene in MalaCards »
genes like me logo Genes that share disorders with HS3ST6: view

No data available for UniProtKB/Swiss-Prot for HS3ST6 Gene

Publications for HS3ST6 Gene

  1. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels R.J. … Higgs D.R. (Hum. Mol. Genet. 2001) 2 3 4
  2. Characterization of heparan sulphate 3-O-sulphotransferase isoform 6 and its role in assisting the entry of herpes simplex virus type 1. (PMID: 15303968) Xu D. … Liu J. (Biochem. J. 2005) 3 4
  3. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4
  4. Heparan sulfate 3-O-sulfotransferase isoform 5 generates both an antithrombin-binding site and an entry receptor for herpes simplex virus, type 1. (PMID: 12138164) Xia G. … Liu J. (J. Biol. Chem. 2002) 3
  5. Characterization of a heparan sulfate 3-O-sulfotransferase-5, an enzyme synthesizing a tetrasulfated disaccharide. (PMID: 12740361) Mochizuki H. … Narimatsu H. (J. Biol. Chem. 2003) 3

Products for HS3ST6 Gene

  • antibodies-online peptides for HS3ST6
  • antibodies-online antibodies for HS3ST6
  • antibodies-online kits for HS3ST6

Sources for HS3ST6 Gene

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