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HS3ST6 Gene

protein-coding   GIFtS: 42
GCID: GC16M001961

Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 6

(Previous name: heparan sulfate (glucosamine) 3-O-sulfotransferase 5)
(Previous symbol: HS3ST5)
  See HS3ST6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 61 2     h3-OST-62 3
HS3ST51 2 3     Heparan Sulfate Glucosamine 3-O-Sulfotransferase 62
Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 51 2     Heparan Sulphate D-Glucosaminyl 3-O-Sulfotransferase-3B Like2
Heparan Sulfate 3-O-Sulfotransferase 62 3     EC 2.8.2.233
Heparan Sulfate D-Glucosaminyl 3-O-Sulfotransferase 62 3     EC 2.8.28
3-OST-62 3     

External Ids:    HGNC: 141781   Entrez Gene: 647112   Ensembl: ENSG000001620407   UniProtKB: Q96QI53   

Export aliases for HS3ST6 gene to outside databases

Previous GC identifers: GC16U900028 GC16M001903 GC16M001905 GC16M001907


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HS3ST6 Gene:
HS3ST6 (heparan sulfate (glucosamine) 3-O-sulfotransferase 6) is a protein-coding gene. Diseases associated with HS3ST6 include mucopolysaccharidoses, and morquio syndrome b. GO annotations related to this gene include [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. An important paralog of this gene is HS3ST2.

UniProtKB/Swiss-Prot: HS3S6_HUMAN, Q96QI5
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo
group to heparan sulfate. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which
acts as a binding receptor to Herpes Simplex Virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not
convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the HS3ST6 gene promoter:
         AhR   SRF   Elk-1   p53   SRF (504 AA)   CUTL1   E47   N-Myc   NRF-2   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHS3ST6 promoter sequence
   Search Chromatin IP Primers for HS3ST6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HS3ST6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

HS3ST6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HS3ST6 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M001961:  view genomic region     (about GC identifiers)

Start:
1,961,464 bp from pter      End:
1,968,441 bp from pter
Size:
6,978 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HS3S6_HUMAN, Q96QI5 (See protein sequence)
Recommended Name: Heparan sulfate glucosamine 3-O-sulfotransferase 6  
Size: 342 amino acids; 37186 Da
Sequence caution: Sequence=AAK61299.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAC42157.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q96RX7

Explore the universe of human proteins at neXtProt for HS3ST6: NX_Q96QI5

Explore proteomics data for HS3ST6 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn281
  • Selected DME Specific Peptides for HS3ST6 (Q96QI5) (see all 7)
     EPHFFDR  TKGFPCLKK  KGGTRALLE  EKTPSYFVT 


    See HS3ST6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001009606.2  
    ENSEMBL proteins: 
     ENSP00000416741   ENSP00000293937   ENSP00000390354  
    Reactome Protein details: Q96QI5

    HS3ST6 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for HS3ST6
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    Novus Biologicals HS3ST6 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HS3ST6

     
    Search eBioscience for Proteins for HS3ST6 

    HS3ST6 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for HS3ST6
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    Search ThermoFisher Antibodies for HS3ST6
    LSBio Antibodies in human, mouse, rat for HS3ST6

    HS3ST6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for HS3ST6
    Cloud-Clone Corp. CLIAs for HS3ST6
    Search eBioscience for ELISAs for HS3ST6 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SULTM: Sulfotransferases, membrane-bound

    2 InterPro protein domains:
     IPR000863 Sulfotransferase_dom
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q96QI5

    ProtoNet protein and cluster: Q96QI5

    UniProtKB/Swiss-Prot: HS3S6_HUMAN, Q96QI5
    Similarity: Belongs to the sulfotransferase 1 family


    Find genes that share domains with HS3ST6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HS3S6_HUMAN, Q96QI5
    Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo
    group to heparan sulfate. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which
    acts as a binding receptor to Herpes Simplex Virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not
    convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate
    Catalytic activity: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate +
    [heparan sulfate]-glucosamine 3-sulfate

         Enzyme Numbers (IUBMB): EC 2.8.2.231 EC 2.8.22

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008146sulfotransferase activity ----
    GO:0008467[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity ISS--
         
    Find genes that share ontologies with HS3ST6           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HS3ST6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HS3ST6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HS3ST6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HS3ST6

    miRNA
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    Block miRNA regulation of human, mouse, rat HS3ST6 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate HS3ST6
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HS3ST6
    Predesigned siRNA for gene silencing in human, mouse, rat HS3ST6

    Gene Editing
    Products:
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HS3ST6 (NM_001009606)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HS3ST6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HS3ST6

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for HS3ST6 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HS3ST6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HS3S6_HUMAN, Q96QI5: Golgi apparatus membrane; Single-pass type II membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    extracellular2
    cytosol1
    endoplasmic reticulum1
    lysosome1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with HS3ST6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HS3ST6 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIIB - Sanfilippo syndrome B0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS II - Hunter syndrome0.45
    MPS IV - Morquio syndrome A0.45
    Glycosaminoglycan metabolism0.45
    Mucopolysaccharidoses0.45
    MPS IV - Morquio syndrome B0.45
    2Heparan sulfate/heparin (HS-GAG) metabolism
    Heparan sulfate/heparin (HS-GAG) metabolism0.57
    HS-GAG biosynthesis0.57
    3Biological oxidations
    metapathway biotransformation0.42
    4Metabolism
    Metabolism0.38
    5Disease
    Disease


    Find genes that share SuperPaths with HS3ST6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for HS3ST6
        metapathway biotransformation

    1 Reactome Pathway for HS3ST6
        HS-GAG biosynthesis


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HS3ST6
    Interactions:

        GeneGlobe Interaction Network for HS3ST6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for HS3ST6 (ENSP000003903544) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GPC1ENSP000002640394STRING: ENSP00000264039
    HS2ST1ENSP000003595814STRING: ENSP00000359581
    HSPG2ENSP000003638274STRING: ENSP00000363827
    AGRNENSP000003686784STRING: ENSP00000368678
    GLCEENSP000002618584STRING: ENSP00000261858
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006024glycosaminoglycan biosynthetic process TAS--
    GO:0030203glycosaminoglycan metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with HS3ST6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HS3ST6 (HS3S6)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HS3ST6 gene: 
    NM_001009606.2  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000454677 ENST00000293937 ENST00000443547(uc002cnf.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HS3ST6 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate HS3ST6
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HS3ST6
    Predesigned siRNA for gene silencing in human, mouse, rat HS3ST6
    Clone
    Products:
         
    OriGene clones in human, mouse for HS3ST6 (see all 6)
    OriGene ORF clones in mouse, rat for HS3ST6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HS3ST6 (NM_001009606)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HS3ST6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HS3ST6
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for HS3ST6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HS3ST6
      QuantiTect SYBR Green Assays in human, mouse, rat HS3ST6
      QuantiFast Probe-based Assays in human, mouse, rat HS3ST6

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HS3ST6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGGCAGAG
    HS3ST6 Expression
    About this image


    HS3ST6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Brain (Nervous System)
             Cerebral Cortex
    HS3ST6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HS3ST6 Protein Expression
        Custom PCR Arrays for HS3ST6
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for HS3ST6
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    QuantiFast Probe-based Assays in human, mouse, rat HS3ST6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HS3ST6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HS3ST6 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hs3st61 , 5 heparan sulfate (glucosamine) 3-O-sulfotransferase more1, 5 85.05(n)1
    90.97(a)1
      17 (12.53 cM)5
    3287791  NM_001012402.11  NP_001012402.11 
     247530035 
    chicken
    (Gallus gallus)
    Aves HS3ST61 heparan sulfate (glucosamine) 3-O-sulfotransferase more 78.85(n)
    81.54(a)
      427669  XM_425243.3  XP_425243.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    36(a)
    many ↔ many
    GL343262.1(515388-516317)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004897391 heparan sulfate glucosamine 3-O-sulfotransferase 3A1-like 71.74(n)
    80.86(a)
      100489739  XM_002935866.2  XP_002935912.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-121b10.71 si:dkey-121b10.7 70.71(n)
    73.48(a)
      797517  XM_001337952.2  XP_001337988.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hs3st-B6
    Heparan sulfate 3-O sulfotransferase-B
    47(a)
    1 ↔ 1
    X(19143021-19146078)
    worm
    (Caenorhabditis elegans)
    Secernentea hst-3.26
    Protein HST-3.2 (hst-3.2) mRNA, complete cds
    44(a)
    1 ↔ 1
    X(2918805-2923984) WBGene00044303


    ENSEMBL Gene Tree for HS3ST6 (if available)
    TreeFam Gene Tree for HS3ST6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HS3ST6 gene
    HS3ST22  NDST22  ENSG000002729162  HS3ST12  HS3ST3B12  HS3ST42  HS3ST3A12  HS3ST52  
    NDST12  NDST42  NDST32  
    6 SIMAP similar genes for HS3ST6 using alignment to 3 protein entries:     HS3S6_HUMAN (see all proteins):
    HS3ST3A1    HS3ST4    HS3ST3B1    HS3ST2    HS3ST5    HS3ST1

    Find genes that share paralogs with HS3ST6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HS3ST6 (see all 272)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1882933951,2
    --1960975(+) GAGGCA/GGAGGT 1 -- ds50010--------
    rs99268741,2
    C,H--1961068(+) aTagcC/Tgggtg 1 -- ds50010--------
    rs1808585541,2
    C--1961085(+) CTCACA/GCCTGT 1 -- ds50010--------
    rs124452091,2
    C,H--1961112(+) GAGGCC/TGAGGC 1 -- ds50012Minor allele frequency- T:0.17NA 6
    rs29824341,2
    C,A,H--1961205(+) TTAGCC/TGGGCG 1 -- ds50012Minor allele frequency- T:0.25NA 4
    rs29824351,2
    C,F,A,H--1961217(+) GGTGGC/TGGGCG 1 -- ds50013Minor allele frequency- T:0.33NA 6
    rs29824361,2
    C,F,A,H--1961221(+) GTGGGC/TGCCTG 1 -- ds50013Minor allele frequency- T:0.50NA 6
    rs29824371,2
    C,F,A,H--1961241(+) CTACTC/TGGGAG 1 -- ds50013Minor allele frequency- T:0.50NA 6
    rs756988391,2
    C--1961257(+) GGCAGC/GAGAAT 1 -- ds50010--------
    rs1865284461,2
    C--1961274(+) AACCCA/GGGAGG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for HS3ST6 (1961464 - 1968441 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for HS3ST6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422427CNV Duplication17116639
    nsv103288CNV Insertion16902084
    nsv833120CNV Loss17160897
    nsv833119CNV Loss17160897
    dgv2545n71CNV Loss21882294
    nsv519366CNV Loss19592680
    nsv905048CNV Loss21882294
    dgv2540n71CNV Loss21882294
    dgv2544n71CNV Loss21882294
    nsv905053CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HS3ST6
    DNA2.0 Custom Variant and Variant Library Synthesis for HS3ST6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for HS3ST6:    
    About MalaCards
    mucopolysaccharidoses    morquio syndrome b


    Find genes that share disorders with HS3ST6           About GenesLikeMe


    Export disorders for HS3ST6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HS3ST6 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with HS3ST6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)1, 2, 3 Daniels R.J....Higgs D.R. (Hum. Mol. Genet. 2001)
    2. Characterization of heparan sulphate 3-O-sulphotransferase isoform 6 and its role in assisting the entry of herpes simplex virus type 1. (PubMed id 15303968)1, 2 Xu D.... Liu J. (Biochem. J. 2005)
    3. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (Nature 2004)
    4. Biosynthesis of 3-O-sulfated heparan sulfate: unique substrate specificity of heparan sulfate 3-O-sulfotransferase isoform 5. (PubMed id 12907690)1 Chen J....Liu J. (Glycobiology 2003)
    5. Characterization of a heparan sulfate 3-O-sulfotransferase-5, an enzyme synthesizing a tetrasulfated disaccharide. (PubMed id 12740361)1 Mochizuki H....Narimatsu H. (J. Biol. Chem. 2003)
    6. Heparan sulfate 3-O-sulfotransferase isoform 5 generates both an antithrombin-binding site and an entry receptor for herpes simplex virus, type 1. (PubMed id 12138164)1 Xia G....Liu J. (J. Biol. Chem. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64711 HGNC: 14178 Ensembl:ENSG00000162040 euGenes: HUgn64711 ECgene: HS3ST6
    H-InvDB: HS3ST6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HS3ST6 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=HS3ST6

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HS3ST6 gene:
    Search GeneIP for patents involving HS3ST6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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