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Aliases for HS3ST6 Gene

Aliases for HS3ST6 Gene

  • Heparan Sulfate-Glucosamine 3-Sulfotransferase 6 2 3 5
  • Heparan Sulfate D-Glucosaminyl 3-O-Sulfotransferase 6 3 4
  • Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 5 2 3
  • Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 6 2 3
  • 3-OST-6 3 4
  • HS3ST5 3 4
  • Heparan Sulphate D-Glucosaminyl 3-O-Sulfotransferase-3B Like 3
  • Heparan Sulfate 3-O-Sulfotransferase 6 4
  • EC 2.8.2.23 4
  • H3-OST-6 4
  • EC 2.8.2 63

External Ids for HS3ST6 Gene

Previous HGNC Symbols for HS3ST6 Gene

  • HS3ST5

Previous GeneCards Identifiers for HS3ST6 Gene

  • GC16U900028
  • GC16M001903
  • GC16M001905
  • GC16M001907
  • GC16M001961

Summaries for HS3ST6 Gene

GeneCards Summary for HS3ST6 Gene

HS3ST6 (Heparan Sulfate-Glucosamine 3-Sulfotransferase 6) is a Protein Coding gene. Among its related pathways are Glycosaminoglycan metabolism and Metabolism. GO annotations related to this gene include sulfotransferase activity and [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. An important paralog of this gene is NDST4.

UniProtKB/Swiss-Prot for HS3ST6 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to heparan sulfate. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes Simplex Virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HS3ST6 Gene

Genomics for HS3ST6 Gene

Regulatory Elements for HS3ST6 Gene

Enhancers for HS3ST6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HS3ST6 on UCSC Golden Path with GeneCards custom track

Genomic Location for HS3ST6 Gene

Chromosome:
16
Start:
1,911,463 bp from pter
End:
1,921,422 bp from pter
Size:
9,960 bases
Orientation:
Minus strand

Genomic View for HS3ST6 Gene

Genes around HS3ST6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HS3ST6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HS3ST6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HS3ST6 Gene

Proteins for HS3ST6 Gene

  • Protein details for HS3ST6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QI5-HS3S6_HUMAN
    Recommended name:
    Heparan sulfate glucosamine 3-O-sulfotransferase 6
    Protein Accession:
    Q96QI5
    Secondary Accessions:
    • Q96RX7

    Protein attributes for HS3ST6 Gene

    Size:
    342 amino acids
    Molecular mass:
    37186 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK61299.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAC42157.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for HS3ST6 Gene

Proteomics data for HS3ST6 Gene at MOPED

Selected DME Specific Peptides for HS3ST6 Gene

Post-translational modifications for HS3ST6 Gene

  • Glycosylation at Asn 281
  • Modification sites at PhosphoSitePlus

Other Protein References for HS3ST6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for HS3ST6 Gene

Gene Families for HS3ST6 Gene

Protein Domains for HS3ST6 Gene

Suggested Antigen Peptide Sequences for HS3ST6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96QI5

UniProtKB/Swiss-Prot:

HS3S6_HUMAN :
  • Belongs to the sulfotransferase 1 family.
Family:
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with HS3ST6: view

Function for HS3ST6 Gene

Molecular function for HS3ST6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3,5-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate.
UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to heparan sulfate. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes Simplex Virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.

Enzyme Numbers (IUBMB) for HS3ST6 Gene

genes like me logo Genes that share phenotypes with HS3ST6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for HS3ST6

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HS3ST6 Gene

Localization for HS3ST6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HS3ST6 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HS3ST6 Gene COMPARTMENTS Subcellular localization image for HS3ST6 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
peroxisome 1
plasma membrane 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for HS3ST6 Gene

Pathways & Interactions for HS3ST6 Gene

genes like me logo Genes that share pathways with HS3ST6: view

Pathways by source for HS3ST6 Gene

Interacting Proteins for HS3ST6 Gene

Gene Ontology (GO) - Biological Process for HS3ST6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030203 glycosaminoglycan metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with HS3ST6: view

No data available for SIGNOR curated interactions for HS3ST6 Gene

Drugs & Compounds for HS3ST6 Gene

(2) Additional Compounds for HS3ST6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
1053-73-2
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
482-67-7
genes like me logo Genes that share compounds with HS3ST6: view

Transcripts for HS3ST6 Gene

mRNA/cDNA for HS3ST6 Gene

(5) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HS3ST6 Gene

Heparan sulfate (glucosamine) 3-O-sulfotransferase 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HS3ST6 Gene

No ASD Table

Relevant External Links for HS3ST6 Gene

GeneLoc Exon Structure for
HS3ST6
ECgene alternative splicing isoforms for
HS3ST6

Expression for HS3ST6 Gene

mRNA expression in normal human tissues for HS3ST6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HS3ST6 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x21.2), Skin - Not Sun Exposed (Suprapubic) (x18.5), and Esophagus - Mucosa (x4.2).

Protein differential expression in normal tissues from HIPED for HS3ST6 Gene

This gene is overexpressed in Pancreatic juice (33.3), Heart (13.7), Adipocyte (9.0), and Platelet (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HS3ST6 Gene



SOURCE GeneReport for Unigene cluster for HS3ST6 Gene Hs.670144

genes like me logo Genes that share expression patterns with HS3ST6: view

Protein tissue co-expression partners for HS3ST6 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HS3ST6 Gene

Orthologs for HS3ST6 Gene

This gene was present in the common ancestor of animals.

Orthologs for HS3ST6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HS3ST6 35
  • 90.22 (n)
  • 88.71 (a)
HS3ST6 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hs3st6 35
  • 85.05 (n)
  • 90.97 (a)
Hs3st6 16
Hs3st6 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hs3st6 35
  • 85.38 (n)
  • 91.29 (a)
dog
(Canis familiaris)
Mammalia HS3ST6 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HS3ST6 36
  • 24 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HS3ST6 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HS3ST6 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves HS3ST6 35
  • 78.85 (n)
  • 81.54 (a)
-- 36
  • 36 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 36 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489739 35
  • 71.74 (n)
  • 80.86 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-121b10.7 35
  • 70.71 (n)
  • 73.48 (a)
HS3ST6 36
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Hs3st-B 36
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea hst-3.2 36
  • 44 (a)
OneToOne
Species with no ortholog for HS3ST6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HS3ST6 Gene

ENSEMBL:
Gene Tree for HS3ST6 (if available)
TreeFam:
Gene Tree for HS3ST6 (if available)

Paralogs for HS3ST6 Gene

(6) SIMAP similar genes for HS3ST6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HS3ST6: view

Variants for HS3ST6 Gene

Sequence variations from dbSNP and Humsavar for HS3ST6 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs3951148 -- 1,920,354(-) TGGGG(A/G)CTCCT intron-variant
rs4027418 -- 1,920,373(-) ATGGG(A/G)ACGGC intron-variant
rs4027419 -- 1,920,370(-) GGGAC(A/G)GCTGA intron-variant
rs8064135 -- 1,916,022(+) CAGGG(G/T)CTCAA intron-variant, upstream-variant-2KB
rs337285 -- 1,911,673(+) GACCA(C/G/T)GGCCT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for HS3ST6 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
dgv2540n71 CNV Loss 21882294
nsv833119 CNV Loss 17160897
nsv519366 CNV Loss 19592680
dgv2544n71 CNV Loss 21882294
dgv2545n71 CNV Loss 21882294
nsv833120 CNV Loss 17160897
nsv905048 CNV Loss 21882294
nsv905053 CNV Gain 21882294
nsv103288 CNV Insertion 16902084

Variation tolerance for HS3ST6 Gene

Residual Variation Intolerance Score: 95.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.24; 98.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HS3ST6 Gene

HapMap Linkage Disequilibrium report
HS3ST6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HS3ST6 Gene

Disorders for HS3ST6 Gene

Relevant External Links for HS3ST6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HS3ST6

No disorders were found for HS3ST6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HS3ST6 Gene

Publications for HS3ST6 Gene

  1. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels R.J. … Higgs D.R. (Hum. Mol. Genet. 2001) 2 3 4 67
  2. Characterization of heparan sulphate 3-O-sulphotransferase isoform 6 and its role in assisting the entry of herpes simplex virus type 1. (PMID: 15303968) Xu D. … Liu J. (Biochem. J. 2005) 3
  3. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3
  4. Characterization of a heparan sulfate 3-O-sulfotransferase-5, an enzyme synthesizing a tetrasulfated disaccharide. (PMID: 12740361) Mochizuki H. … Narimatsu H. (J. Biol. Chem. 2003) 3
  5. Biosynthesis of 3-O-sulfated heparan sulfate: unique substrate specificity of heparan sulfate 3-O-sulfotransferase isoform 5. (PMID: 12907690) Chen J. … Liu J. (Glycobiology 2003) 3

Products for HS3ST6 Gene

Sources for HS3ST6 Gene

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