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Aliases for HS3ST5 Gene

Aliases for HS3ST5 Gene

  • Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 5 2 3
  • Heparan Sulfate D-Glucosaminyl 3-O-Sulfotransferase 5 3 4
  • Heparan Sulfate 3-O-Sulfotransferase 5 3 4
  • EC 2.8.2.23 4 63
  • H3-OST-5 3 4
  • 3-OST-5 3 4
  • HS3OST5 3 4
  • 3OST5 3 4
  • Heparan Sulfate 3-OST-5 3
  • NBLA04021 3
  • EC 2.8.2 63

External Ids for HS3ST5 Gene

Previous GeneCards Identifiers for HS3ST5 Gene

  • GC16U990169
  • GC06M114376
  • GC06M114422
  • GC06M114485
  • GC06M111953

Summaries for HS3ST5 Gene

Entrez Gene Summary for HS3ST5 Gene

  • HS3ST5 belongs to a group of heparan sulfate 3-O-sulfotransferases (EC 2.8.2.23) that transfer sulfate from 3-prime-phosphoadenosine 5-prime phosphosulfate (PAPS) to heparan sulfate and heparin (Mochizuki et al., 2003 [PubMed 12740361]).[supplied by OMIM, Mar 2008]

GeneCards Summary for HS3ST5 Gene

HS3ST5 (Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 5) is a Protein Coding gene. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include sulfotransferase activity and [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. An important paralog of this gene is NDST4.

UniProtKB/Swiss-Prot for HS3ST5 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Also generates GlcUA-GlcNS or IdoUA-GlcNS and IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HS3ST5 Gene

Genomics for HS3ST5 Gene

Regulatory Elements for HS3ST5 Gene

Genomic Location for HS3ST5 Gene

Chromosome:
6
Start:
114,055,586 bp from pter
End:
114,343,045 bp from pter
Size:
287,460 bases
Orientation:
Minus strand

Genomic View for HS3ST5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HS3ST5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HS3ST5 Gene

Proteins for HS3ST5 Gene

  • Protein details for HS3ST5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZT8-HS3S5_HUMAN
    Recommended name:
    Heparan sulfate glucosamine 3-O-sulfotransferase 5
    Protein Accession:
    Q8IZT8
    Secondary Accessions:
    • A8K1J2
    • Q52LI2
    • Q8N285

    Protein attributes for HS3ST5 Gene

    Size:
    346 amino acids
    Molecular mass:
    40408 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HS3ST5 Gene

neXtProt entry for HS3ST5 Gene

Proteomics data for HS3ST5 Gene at MOPED

Selected DME Specific Peptides for HS3ST5 Gene

Post-translational modifications for HS3ST5 Gene

  • Glycosylation at Asn 287
  • Modification sites at PhosphoSitePlus

Other Protein References for HS3ST5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for HS3ST5 Gene

Gene Families for HS3ST5 Gene

Protein Domains for HS3ST5 Gene

Suggested Antigen Peptide Sequences for HS3ST5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZT8

UniProtKB/Swiss-Prot:

HS3S5_HUMAN :
  • Belongs to the sulfotransferase 1 family.
Family:
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with HS3ST5: view

Function for HS3ST5 Gene

Molecular function for HS3ST5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3,5-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate.
UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Also generates GlcUA-GlcNS or IdoUA-GlcNS and IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry.

Enzyme Numbers (IUBMB) for HS3ST5 Gene

Gene Ontology (GO) - Molecular Function for HS3ST5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12138164
GO:0008146 sulfotransferase activity --
GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IDA 12138164
GO:0050656 3-phosphoadenosine 5-phosphosulfate binding NAS 12138164
genes like me logo Genes that share ontologies with HS3ST5: view
genes like me logo Genes that share phenotypes with HS3ST5: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HS3ST5

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for HS3ST5 Gene

Localization for HS3ST5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HS3ST5 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HS3ST5 Gene COMPARTMENTS Subcellular localization image for HS3ST5 gene
Compartment Confidence
golgi apparatus 4
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for HS3ST5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0016021 integral component of membrane NAS 12138164
genes like me logo Genes that share ontologies with HS3ST5: view

Pathways & Interactions for HS3ST5 Gene

genes like me logo Genes that share pathways with HS3ST5: view

Interacting Proteins for HS3ST5 Gene

Gene Ontology (GO) - Biological Process for HS3ST5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006024 glycosaminoglycan biosynthetic process TAS --
GO:0006477 protein sulfation IDA 12138164
GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification IDA 12138164
GO:0030203 glycosaminoglycan metabolic process TAS --
genes like me logo Genes that share ontologies with HS3ST5: view

No data available for SIGNOR curated interactions for HS3ST5 Gene

Drugs & Compounds for HS3ST5 Gene

(2) Additional Compounds for HS3ST5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
1053-73-2
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
482-67-7
genes like me logo Genes that share compounds with HS3ST5: view

Transcripts for HS3ST5 Gene

mRNA/cDNA for HS3ST5 Gene

(4) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HS3ST5 Gene

Heparan sulfate (glucosamine) 3-O-sulfotransferase 5:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HS3ST5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HS3ST5 Gene

No ASD Table

Relevant External Links for HS3ST5 Gene

GeneLoc Exon Structure for
HS3ST5
ECgene alternative splicing isoforms for
HS3ST5

Expression for HS3ST5 Gene

mRNA expression in normal human tissues for HS3ST5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HS3ST5 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x9.3), Brain - Putamen (basal ganglia) (x9.1), Brain - Nucleus accumbens (basal ganglia) (x6.6), and Brain - Spinal cord (cervical c-1) (x5.1).

SOURCE GeneReport for Unigene cluster for HS3ST5 Gene Hs.645477

mRNA Expression by UniProt/SwissProt for HS3ST5 Gene

Q8IZT8-HS3S5_HUMAN
Tissue specificity: Highly expressed in skeletal muscle and fetal brain, and also found in adult brain, spinal cord, cerebellum and colon.
genes like me logo Genes that share expression patterns with HS3ST5: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for HS3ST5 Gene

Orthologs for HS3ST5 Gene

This gene was present in the common ancestor of animals.

Orthologs for HS3ST5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HS3ST5 35
  • 94.59 (n)
  • 98.26 (a)
HS3ST5 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HS3ST5 35
  • 93.53 (n)
  • 98.26 (a)
HS3ST5 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hs3st5 35
  • 90.17 (n)
  • 96.82 (a)
Hs3st5 16
Hs3st5 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HS3ST5 35
  • 99.61 (n)
  • 99.71 (a)
HS3ST5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hs3st5 35
  • 89.69 (n)
  • 96.24 (a)
oppossum
(Monodelphis domestica)
Mammalia HS3ST5 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HS3ST5 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves HS3ST5 35
  • 85.89 (n)
  • 93.91 (a)
HS3ST5 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HS3ST5 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hs3st5 35
  • 80.58 (n)
  • 91.59 (a)
zebrafish
(Danio rerio)
Actinopterygii hs3st1l2 36
  • 46 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006169 35
  • 58.2 (n)
  • 60.48 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hs3st-A 35
  • 58.5 (n)
  • 60 (a)
Hs3st-A 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hst-3.1 36
  • 39 (a)
OneToMany
Species with no ortholog for HS3ST5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HS3ST5 Gene

ENSEMBL:
Gene Tree for HS3ST5 (if available)
TreeFam:
Gene Tree for HS3ST5 (if available)

Paralogs for HS3ST5 Gene

(6) SIMAP similar genes for HS3ST5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HS3ST5: view

Variants for HS3ST5 Gene

Sequence variations from dbSNP and Humsavar for HS3ST5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs748420 -- 114,341,907(+) GAGAG(A/C)CTGAG intron-variant
VAR_052531 -
rs781476156 -- 114,344,284(+) ATTCC(C/T)TTTTA upstream-variant-2KB
rs778812794 -- 114,342,835(+) AGCTG(G/T)GCGGG upstream-variant-2KB
rs774201760 -- 114,342,168(+) CCCGC(G/T)CGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HS3ST5 Gene

Variant ID Type Subtype PubMed ID
nsv819824 CNV Loss 19587683

Variation tolerance for HS3ST5 Gene

Residual Variation Intolerance Score: 51.27% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HS3ST5 Gene

HapMap Linkage Disequilibrium report
HS3ST5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HS3ST5 Gene

Disorders for HS3ST5 Gene

Relevant External Links for HS3ST5

Genetic Association Database (GAD)
HS3ST5
Human Genome Epidemiology (HuGE) Navigator
HS3ST5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HS3ST5
genes like me logo Genes that share disorders with HS3ST5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HS3ST5 Gene

Publications for HS3ST5 Gene

  1. Heparan sulfate 3-O-sulfotransferase isoform 5 generates both an antithrombin-binding site and an entry receptor for herpes simplex virus, type 1. (PMID: 12138164) Xia G. … Liu J. (J. Biol. Chem. 2002) 2 23 67
  2. Genome-wide association analysis with gray matter volume as a quantitative phenotype in first-episode treatment-naA^ve patients with schizophrenia. (PMID: 24086445) Wang Q. … Li T. (PLoS ONE 2013) 67
  3. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 67
  4. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PMID: 18978678) Vieira A.R. … Marazita M.L. (Genet. Med. 2008) 67
  5. Engineering sulfotransferases to modify heparan sulfate. (PMID: 18223645) Xu D. … Liu J. (Nat. Chem. Biol. 2008) 67

Products for HS3ST5 Gene

Sources for HS3ST5 Gene

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