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HS3ST5 Gene

protein-coding   GIFtS: 53
GCID: GC06M114376

Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 5

  See HS3ST5-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 51 2     h3-OST-52 3
3OST52 3 5     EC 2.8.2.233 8
Heparan Sulfate 3-O-Sulfotransferase 52 3     NBLA040212
Heparan Sulfate D-Glucosaminyl 3-O-Sulfotransferase 52 3     Heparan Sulfate 3-OST-52
3-OST-52 3     Heparan Sulfate Glucosamine 3-O-Sulfotransferase 52
HS3OST52 3     EC 2.8.28

External Ids:    HGNC: 194191   Entrez Gene: 2225372   Ensembl: ENSG000002498537   OMIM: 6094075   UniProtKB: Q8IZT83   

Export aliases for HS3ST5 gene to outside databases

Previous GC identifers: GC16U990169 GC06M114422 GC06M114485 GC06M111953


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HS3ST5 Gene:
HS3ST5 belongs to a group of heparan sulfate 3-O-sulfotransferases (EC 2.8.2.23) that transfer sulfate from
3-prime-phosphoadenosine 5-prime phosphosulfate (PAPS) to heparan sulfate and heparin (Mochizuki et al., 2003
(PubMed 12740361)).(supplied by OMIM, Mar 2008)

GeneCards Summary for HS3ST5 Gene:
HS3ST5 (heparan sulfate (glucosamine) 3-O-sulfotransferase 5) is a protein-coding gene. Diseases associated with HS3ST5 include mucopolysaccharidoses. GO annotations related to this gene include [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity and 3'-phosphoadenosine 5'-phosphosulfate binding. An important paralog of this gene is HS3ST2.

UniProtKB/Swiss-Prot: HS3S5_HUMAN, Q8IZT8
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo
group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of
heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate
as it completes the structure of the antithrombin pentasaccharide binding site. Also generates GlcUA-GlcNS or
IdoUA-GlcNS and IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate
which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HS3ST5 gene promoter:
         LHX3b/Lhx3b   AML1a   YY1   MEF-2A   IRF-2   LHX3a/Lhx3a   aMEF-2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHS3ST5 promoter sequence
   Search Chromatin IP Primers for HS3ST5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HS3ST5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q22.1   HGNC cytogenetic band: 6q21

HS3ST5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HS3ST5 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M114376:  view genomic region     (about GC identifiers)

Start:
114,376,750 bp from pter      End:
114,664,209 bp from pter
Size:
287,460 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HS3S5_HUMAN, Q8IZT8 (See protein sequence)
Recommended Name: Heparan sulfate glucosamine 3-O-sulfotransferase 5  
Size: 346 amino acids; 40408 Da
1 PDB 3D structure from and Proteopedia for HS3ST5:
3BD9 (3D)    
Secondary accessions: A8K1J2 Q52LI2 Q8N285

Explore the universe of human proteins at neXtProt for HS3ST5: NX_Q8IZT8

Explore proteomics data for HS3ST5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn287
  • 2 DME Specific Peptides for HS3ST5 (Q8IZT8)
     KGGTRALLE  IIIGVRKGGTRALLEML 


    See HS3ST5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_705840.2  
    ENSEMBL proteins: 
     ENSP00000427888   ENSP00000440332  
    Reactome Protein details: Q8IZT8

    HS3ST5 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SULTM: Sulfotransferases, membrane-bound

    2 InterPro protein domains:
     IPR000863 Sulfotransferase_dom
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q8IZT8

    ProtoNet protein and cluster: Q8IZT8

    UniProtKB/Swiss-Prot: HS3S5_HUMAN, Q8IZT8
    Similarity: Belongs to the sulfotransferase 1 family


    Find genes that share domains with HS3ST5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HS3S5_HUMAN, Q8IZT8
    Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo
    group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of
    heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate
    as it completes the structure of the antithrombin pentasaccharide binding site. Also generates GlcUA-GlcNS or
    IdoUA-GlcNS and IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate
    which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry
    Catalytic activity: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate +
    [heparan sulfate]-glucosamine 3-sulfate

         Enzyme Numbers (IUBMB): EC 2.8.2.231 2 EC 2.8.22

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12138164
    GO:0008146sulfotransferase activity ----
    GO:0008467[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IDA12138164
    GO:00506563'-phosphoadenosine 5'-phosphosulfate binding NAS12138164
         
    Find genes that share ontologies with HS3ST5           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for HS3ST5:
     G0/1 arrest  Increased G1 DNA content  Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HS3ST5

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    hsa-miR-4328 hsa-miR-106a hsa-miR-16-1* hsa-miR-301a hsa-miR-519a hsa-miR-133a hsa-miR-93 hsa-miR-526b*
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HS3S5_HUMAN, Q8IZT8: Golgi apparatus membrane; Single-pass type II membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    extracellular2
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0016021integral component of membrane NAS12138164

    Find genes that share ontologies with HS3ST5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HS3ST5 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1heparan sulfate biosynthesis
    heparan sulfate biosynthesis0.79
    heparan sulfate biosynthesis (late stages)0.00
    Glycosaminoglycan biosynthesis - heparan sulfate / heparin0.79
    2MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIIB - Sanfilippo syndrome B0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS II - Hunter syndrome0.45
    MPS IV - Morquio syndrome A0.45
    Glycosaminoglycan metabolism0.45
    Mucopolysaccharidoses0.45
    MPS IV - Morquio syndrome B0.45
    3Heparan sulfate/heparin (HS-GAG) metabolism
    Heparan sulfate/heparin (HS-GAG) metabolism0.57
    HS-GAG biosynthesis0.57
    4Metabolism
    Metabolism0.38
    5Disease
    Disease


    Find genes that share SuperPaths with HS3ST5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for HS3ST5
        heparan sulfate biosynthesis (late stages)
    heparan sulfate biosynthesis

    1 Reactome Pathway for HS3ST5
        HS-GAG biosynthesis


    1 Kegg Pathway  (Kegg details for HS3ST5):
        Glycosaminoglycan biosynthesis - heparan sulfate / heparin

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HS3ST5
    Interactions:

        GeneGlobe Interaction Network for HS3ST5

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006024glycosaminoglycan biosynthetic process TAS--
    GO:0006477protein sulfation IDA12138164
    GO:0015015heparan sulfate proteoglycan biosynthetic process, enzymatic modification IDA12138164
    GO:0030203glycosaminoglycan metabolic process TAS--

    Find genes that share ontologies with HS3ST5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for HS3ST5 (HS3S5)

    2 HMDB Compounds for HS3ST5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine 3',5'-diphosphate3,5-Diphosphoadenosine (see all 10)1053-73-2--
    Phosphoadenosine phosphosulfate3'-Phospho-5'-adenylyl sulfate (see all 9)482-67-7--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HS3ST5 gene: 
    NM_153612.3  

    Unigene Cluster for HS3ST5:

    Heparan sulfate (glucosamine) 3-O-sulfotransferase 5
    Hs.645477  [show with all ESTs]
    Unigene Representative Sequence: AK126930
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000312719(uc003pwh.4) ENST00000441954 ENST00000411826(uc003pwg.4)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate HS3ST5 (see all 34):
    hsa-miR-4328 hsa-miR-106a hsa-miR-16-1* hsa-miR-301a hsa-miR-519a hsa-miR-133a hsa-miR-93 hsa-miR-526b*
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      QuantiFast Probe-based Assays in human, mouse, rat HS3ST5

    Additional mRNA sequence: 

    AB074164.1 AF503292.1 AK091074.1 AK126930.1 AK289907.1 BC093911.1 BC093913.1 

    2 DOTS entries:

    DT.75182866  DT.101956633 

    11 AceView cDNA sequences:

    AF503292 BE671494 NM_153612 BX089930 AI797060 AI631027 BQ082285 AW449310 
    AA812660 BG187086 BF844531 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HS3ST5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HS3ST5 Expression
    About this image


    HS3ST5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
    HS3ST5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HS3ST5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.645477

    UniProtKB/Swiss-Prot: HS3S5_HUMAN, Q8IZT8
    Tissue specificity: Highly expressed in skeletal muscle and fetal brain, and also found in adult brain, spinal
    cord, cerebellum and colon

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HS3ST5 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hs3st51 , 5 heparan sulfate (glucosamine) 3-O-sulfotransferase more1, 5 90.17(n)1
    96.82(a)1
      10 (19.31 cM)5
    3194151  NM_001081208.21  NP_001074677.11 
     365068145 
    chicken
    (Gallus gallus)
    Aves HS3ST51 heparan sulfate (glucosamine) 3-O-sulfotransferase more 85.89(n)
    93.91(a)
      428621  XM_004940295.1  XP_004940352.1 
    lizard
    (Anolis carolinensis)
    Reptilia HS3ST56
    heparan sulfate (glucosamine) 3-O-sulfotransferase...
    94(a)
    1 ↔ 1
    1(187327876-187611375)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia hs3st51 heparan sulfate (glucosamine) 3-O-sulfotransferase more 80.58(n)
    91.59(a)
      100145790  NM_001127152.1  NP_001120624.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hs3st1l26
    heparan sulfate (glucosamine) 3-O-sulfotransferase...
    46(a)
    many ↔ many
    5(22883684-22924418) ENSDARG00000035578
    fruit fly
    (Drosophila melanogaster)
    Insecta Hs3st-A1 Heparan sulfate 3-O sulfotransferase-A 58.5(n)
    60(a)
      37161  NM_176229.2  NP_788409.1 
    worm
    (Caenorhabditis elegans)
    Secernentea hst-3.16
    Protein HST-3.1 (hst-3.1) mRNA, complete cds
    39(a)
    1 → many
    II(6165721-6169231) WBGene00002030


    ENSEMBL Gene Tree for HS3ST5 (if available)
    TreeFam Gene Tree for HS3ST5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HS3ST5 gene
    HS3ST22  NDST22  ENSG000002729162  HS3ST12  HS3ST3B12  HS3ST42  HS3ST62  HS3ST3A12  
    NDST12  NDST42  NDST32  
    6 SIMAP similar genes for HS3ST5 using alignment to 1 protein entry:     HS3S5_HUMAN:
    HS3ST1    HS3ST2    HS3ST6    HS3ST3B1    HS3ST3A1    HS3ST4

    Find genes that share paralogs with HS3ST5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HS3ST5 (see all 197)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1873825051,2
    --114376573(+) TAGGGG/TAGAAG 1 -- ds50010--------
    rs1917911961,2
    --114376575(+) GGGGAC/GAAGTG 1 -- ds50010--------
    rs77489631,2
    C,F,A,H--114376730(+) AGGCGG/CTGGCT 1 -- ds500126Minor allele frequency- C:0.37EA NA NS WA CSA 1613
    rs1459989381,2
    C--114376816(+) AGGATA/GAACAA 1 -- ut310--------
    rs777265851,2
    C,F--114376832(+) GGAGAA/GAATCA 1 -- ut311Minor allele frequency- G:0.09EA 120
    rs170758161,2
    C,F,H--114376866(+) ATCCAT/CTGTAA 1 -- ut318Minor allele frequency- C:0.06NA NS EA WA 680
    rs1140100541,2
    C,F--114376919(+) AACTCT/CCTCAA 1 -- ut311Minor allele frequency- C:0.02WA 118
    rs757709501,2
    C,F--114376987(+) TTGTCG/ATTGTT 1 -- ut311Minor allele frequency- A:0.08WA 118
    rs1840548911,2
    --114377055(+) TTAGCA/GAGGCA 1 -- ut310--------
    rs735524991,2
    C--114377150(+) CAGAGC/TAAATT 1 -- ut311Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for HS3ST5 (114376750 - 114626750 bp, first 250kb of HS3ST5)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HS3ST5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv819824CNV Loss19587683

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing HS3ST5
    DNA2.0 Custom Variant and Variant Library Synthesis for HS3ST5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609407    OMIM disorders: --

    1 disease for HS3ST5:    
    About MalaCards
    mucopolysaccharidoses

    1 disease from the University of Copenhagen DISEASES database for HS3ST5:
    Herpes simplex

    Find genes that share disorders with HS3ST5           About GenesLikeMe

    Genetic Association Database (GAD): HS3ST5
    Human Genome Epidemiology (HuGE) Navigator: HS3ST5 (1 document)

    Export disorders for HS3ST5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HS3ST5 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with HS3ST5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Heparan sulfate 3-O-sulfotransferase isoform 5 generates both an antithrombin-binding site and an entry receptor for herpes simplex virus, type 1. (PubMed id 12138164)1, 2, 3, 9 Xia G....Liu J. (J. Biol. Chem. 2002)
    2. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)1, 4 Vieira A.R....Marazita M.L. (Genet. Med. 2008)
    3. The biosynthesis of anticoagulant heparan sulfate by the heparan sulfate 3-O-sulfotransferase isoform 5. (PubMed id 15026143)1, 2 Duncan M.B.... Liu J. (Biochim. Biophys. Acta 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Characterization of a heparan sulfate 3-O-sulfotransferase-5, an enzyme synthesizing a tetrasulfated disaccharide. (PubMed id 12740361)1, 2 Mochizuki H....Narimatsu H. (J. Biol. Chem. 2003)
    7. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    8. Engineering sulfotransferases to modify heparan sulfate. (PubMed id 18223645)2 Xu D.... Liu J. (Nat. Chem. Biol. 2008)
    9. Characterization of the structure of antithrombin-binding heparan sulfate generated by heparan sulfate 3-O-sulfotransferase 5. (PubMed id 16099108)1 Chen J. and Liu J. (Biochim. Biophys. Acta 2005)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 222537 HGNC: 19419 AceView: HS3ST5 Ensembl:ENSG00000249853 euGenes: HUgn222537
    ECgene: HS3ST5 Kegg: 222537 H-InvDB: HS3ST5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HS3ST5 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=HS3ST5

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HS3ST5 gene:
    Search GeneIP for patents involving HS3ST5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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