Aliases for HS3ST5 Gene
External Ids for HS3ST5 Gene
Previous GeneCards Identifiers for HS3ST5 Gene
HS3ST5 belongs to a group of heparan sulfate 3-O-sulfotransferases (EC 126.96.36.199) that transfer sulfate from 3-prime-phosphoadenosine 5-prime phosphosulfate (PAPS) to heparan sulfate and heparin (Mochizuki et al., 2003 [PubMed 12740361]).[supplied by OMIM, Mar 2008]
GeneCards Summary for HS3ST5 Gene
HS3ST5 (Heparan Sulfate-Glucosamine 3-Sulfotransferase 5) is a Protein Coding gene. Diseases associated with HS3ST5 include Spherocytosis, Type 3. Among its related pathways are Glycosaminoglycan metabolism and heparan sulfate biosynthesis. GO annotations related to this gene include sulfotransferase activity and [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. An important paralog of this gene is HS3ST1.
UniProtKB/Swiss-Prot for HS3ST5 Gene
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Also generates GlcUA-GlcNS or IdoUA-GlcNS and IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry.