Aliases for HS3ST5 Gene
External Ids for HS3ST5 Gene
Previous GeneCards Identifiers for HS3ST5 Gene
HS3ST5 belongs to a group of heparan sulfate 3-O-sulfotransferases (EC 126.96.36.199) that transfer sulfate from 3-prime-phosphoadenosine 5-prime phosphosulfate (PAPS) to heparan sulfate and heparin (Mochizuki et al., 2003 [PubMed 12740361]).[supplied by OMIM, Mar 2008]
GeneCards Summary for HS3ST5 Gene
HS3ST5 (Heparan Sulfate-Glucosamine 3-Sulfotransferase 5) is a Protein Coding gene. Diseases associated with HS3ST5 include Spherocytosis, Type 3 and Mental Retardation And Microcephaly With Pontine And Cerebellar Hypoplasia. Among its related pathways are Glycosaminoglycan metabolism and Metabolism. GO annotations related to this gene include sulfotransferase activity and [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. An important paralog of this gene is HS3ST1.
UniProtKB/Swiss-Prot for HS3ST5 Gene
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Also generates GlcUA-GlcNS or IdoUA-GlcNS and IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry.