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Aliases for HS3ST5 Gene

Aliases for HS3ST5 Gene

  • Heparan Sulfate-Glucosamine 3-Sulfotransferase 5 2 3 5
  • Heparan Sulfate D-Glucosaminyl 3-O-Sulfotransferase 5 3 4
  • Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 5 2 3
  • Heparan Sulfate 3-O-Sulfotransferase 5 3 4
  • EC 2.8.2.23 4 61
  • H3-OST-5 3 4
  • 3-OST-5 3 4
  • HS3OST5 3 4
  • 3OST5 3 4
  • Heparan Sulfate Glucosamine 3-O-Sulfotransferase 5 3
  • Heparan Sulfate 3-OST-5 3
  • NBLA04021 3
  • EC 2.8.2 61

External Ids for HS3ST5 Gene

Previous GeneCards Identifiers for HS3ST5 Gene

  • GC16U990169
  • GC06M114376
  • GC06M114422
  • GC06M114485
  • GC06M111953

Summaries for HS3ST5 Gene

Entrez Gene Summary for HS3ST5 Gene

  • HS3ST5 belongs to a group of heparan sulfate 3-O-sulfotransferases (EC 2.8.2.23) that transfer sulfate from 3-prime-phosphoadenosine 5-prime phosphosulfate (PAPS) to heparan sulfate and heparin (Mochizuki et al., 2003 [PubMed 12740361]).[supplied by OMIM, Mar 2008]

GeneCards Summary for HS3ST5 Gene

HS3ST5 (Heparan Sulfate-Glucosamine 3-Sulfotransferase 5) is a Protein Coding gene. Diseases associated with HS3ST5 include Spherocytosis, Type 3. Among its related pathways are Glycosaminoglycan metabolism and heparan sulfate biosynthesis. GO annotations related to this gene include sulfotransferase activity and [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. An important paralog of this gene is HS3ST1.

UniProtKB/Swiss-Prot for HS3ST5 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Also generates GlcUA-GlcNS or IdoUA-GlcNS and IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HS3ST5 Gene

Genomics for HS3ST5 Gene

Regulatory Elements for HS3ST5 Gene

Enhancers for HS3ST5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G114363 0.5 ENCODE 11.6 -21.3 -21310 1.6 SMARCA4 FOSL2 FOS MAFK HS3ST5 DNAJA1P4 GC06P114396
GH06G114070 0.3 FANTOM5 12.7 +272.7 272685 0.2 HS3ST5 RPSAP43 GC06P114038
GH06G113824 1.4 FANTOM5 Ensembl ENCODE 1.9 +517.7 517741 2.5 ELF3 FOXA2 ATF1 THRB RAD21 RARA ZNF335 GATA4 CREM CEBPB FLJ34503 HS3ST5 RPL30P8 GC06M113782
GH06G113666 0.4 FANTOM5 2.6 +676.2 676150 0.1 ZNF366 ZNF512 MARCKS HS3ST5 LOC101927686 GC06M113638
GH06G114341 1.2 ENCODE dbSUPER 0.7 +0.3 347 3.1 ARID4B FEZF1 GLI4 ZNF2 ZNF48 GLIS2 ZNF263 ZNF202 SP3 ZNF610 HS3ST5 GC06M114221 RNA5SP213
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HS3ST5 on UCSC Golden Path with GeneCards custom track

Promoters for HS3ST5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000201584 145 1801 ARID4B KLF17 FEZF1 GLI4 ZNF2 ZNF48 RAD21 RARA GLIS2 ZNF366

Genomic Location for HS3ST5 Gene

Chromosome:
6
Start:
114,055,586 bp from pter
End:
114,343,045 bp from pter
Size:
287,460 bases
Orientation:
Minus strand

Genomic View for HS3ST5 Gene

Genes around HS3ST5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HS3ST5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HS3ST5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HS3ST5 Gene

Proteins for HS3ST5 Gene

  • Protein details for HS3ST5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZT8-HS3S5_HUMAN
    Recommended name:
    Heparan sulfate glucosamine 3-O-sulfotransferase 5
    Protein Accession:
    Q8IZT8
    Secondary Accessions:
    • A8K1J2
    • Q52LI2
    • Q8N285

    Protein attributes for HS3ST5 Gene

    Size:
    346 amino acids
    Molecular mass:
    40408 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HS3ST5 Gene

neXtProt entry for HS3ST5 Gene

Selected DME Specific Peptides for HS3ST5 Gene

Q8IZT8:
  • IIIGVRKGGTRALLEML
  • KGGTRALLE

Post-translational modifications for HS3ST5 Gene

  • Glycosylation at posLast=287287
  • Modification sites at PhosphoSitePlus

Domains & Families for HS3ST5 Gene

Gene Families for HS3ST5 Gene

Protein Domains for HS3ST5 Gene

Suggested Antigen Peptide Sequences for HS3ST5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZT8

UniProtKB/Swiss-Prot:

HS3S5_HUMAN :
  • Belongs to the sulfotransferase 1 family.
Family:
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with HS3ST5: view

Function for HS3ST5 Gene

Molecular function for HS3ST5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3,5-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate.
UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Also generates GlcUA-GlcNS or IdoUA-GlcNS and IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry.

Enzyme Numbers (IUBMB) for HS3ST5 Gene

Gene Ontology (GO) - Molecular Function for HS3ST5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12138164
GO:0008146 sulfotransferase activity IEA --
GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity TAS --
GO:0016740 transferase activity IEA --
GO:0050656 3-phosphoadenosine 5-phosphosulfate binding NAS 12138164
genes like me logo Genes that share ontologies with HS3ST5: view
genes like me logo Genes that share phenotypes with HS3ST5: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HS3ST5 Gene

Localization for HS3ST5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HS3ST5 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HS3ST5 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for HS3ST5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 12138164
genes like me logo Genes that share ontologies with HS3ST5: view

Pathways & Interactions for HS3ST5 Gene

genes like me logo Genes that share pathways with HS3ST5: view

Interacting Proteins for HS3ST5 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000427888%0d%0a9606.ENSP00000264039%0d%0a9606.ENSP00000361818%0d%0a9606.ENSP00000254351%0d%0a9606.ENSP00000366267%0d%0a9606.ENSP00000366246%0d%0a
Selected Interacting proteins: ENSP00000427888 Q8IZT8-HS3S5_HUMAN for HS3ST5 Gene via STRING IID

Gene Ontology (GO) - Biological Process for HS3ST5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006024 glycosaminoglycan biosynthetic process TAS --
GO:0006477 protein sulfation IDA 12138164
GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification IDA 12138164
GO:0046596 regulation of viral entry into host cell IDA 12138164
GO:0050819 negative regulation of coagulation IDA 12138164
genes like me logo Genes that share ontologies with HS3ST5: view

No data available for SIGNOR curated interactions for HS3ST5 Gene

Drugs & Compounds for HS3ST5 Gene

(2) Additional Compounds for HS3ST5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
1053-73-2
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
482-67-7
genes like me logo Genes that share compounds with HS3ST5: view

Transcripts for HS3ST5 Gene

mRNA/cDNA for HS3ST5 Gene

(8) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HS3ST5 Gene

Heparan sulfate (glucosamine) 3-O-sulfotransferase 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HS3ST5 Gene

No ASD Table

Relevant External Links for HS3ST5 Gene

GeneLoc Exon Structure for
HS3ST5
ECgene alternative splicing isoforms for
HS3ST5

Expression for HS3ST5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HS3ST5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HS3ST5 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x9.3), Brain - Putamen (basal ganglia) (x9.1), Brain - Nucleus accumbens (basal ganglia) (x6.6), and Brain - Spinal cord (cervical c-1) (x5.1).

NURSA nuclear receptor signaling pathways regulating expression of HS3ST5 Gene:

HS3ST5

SOURCE GeneReport for Unigene cluster for HS3ST5 Gene:

Hs.645477

mRNA Expression by UniProt/SwissProt for HS3ST5 Gene:

Q8IZT8-HS3S5_HUMAN
Tissue specificity: Highly expressed in skeletal muscle and fetal brain, and also found in adult brain, spinal cord, cerebellum and colon.

Evidence on tissue expression from TISSUES for HS3ST5 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with HS3ST5: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HS3ST5 Gene

Orthologs for HS3ST5 Gene

This gene was present in the common ancestor of animals.

Orthologs for HS3ST5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HS3ST5 34 35
  • 99.61 (n)
oppossum
(Monodelphis domestica)
Mammalia HS3ST5 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HS3ST5 34 35
  • 94.59 (n)
dog
(Canis familiaris)
Mammalia HS3ST5 34 35
  • 93.53 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HS3ST5 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hs3st5 34 16 35
  • 90.17 (n)
rat
(Rattus norvegicus)
Mammalia Hs3st5 34
  • 89.69 (n)
chicken
(Gallus gallus)
Aves HS3ST5 34 35
  • 85.89 (n)
lizard
(Anolis carolinensis)
Reptilia HS3ST5 35
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hs3st5 34
  • 80.58 (n)
zebrafish
(Danio rerio)
Actinopterygii hs3st1l2 35
  • 46 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Hs3st-A 34 35
  • 58.5 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006169 34
  • 58.2 (n)
worm
(Caenorhabditis elegans)
Secernentea hst-3.1 35
  • 39 (a)
OneToMany
Species where no ortholog for HS3ST5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HS3ST5 Gene

ENSEMBL:
Gene Tree for HS3ST5 (if available)
TreeFam:
Gene Tree for HS3ST5 (if available)

Paralogs for HS3ST5 Gene

(6) SIMAP similar genes for HS3ST5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HS3ST5: view

Variants for HS3ST5 Gene

Sequence variations from dbSNP and Humsavar for HS3ST5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000001846 -- 114,264,416(+) TGCCC(C/G)CAATA intron-variant
rs1000013636 -- 114,340,025(+) ATTGT(G/T)TGTGT intron-variant
rs1000020413 -- 114,136,322(+) GATCT(A/G)ATGGT intron-variant
rs1000051471 -- 114,249,539(+) TAATT(C/T)CCTCA intron-variant, utr-variant-5-prime
rs1000057590 -- 114,090,001(+) TTGGG(A/G)AGGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HS3ST5 Gene

Variant ID Type Subtype PubMed ID
nsv819824 CNV loss 19587683

Variation tolerance for HS3ST5 Gene

Residual Variation Intolerance Score: 51.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HS3ST5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HS3ST5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HS3ST5 Gene

Disorders for HS3ST5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HS3ST5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spherocytosis, type 3
  • hereditary spherocytosis type 3
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HS3ST5

Genetic Association Database (GAD)
HS3ST5
Human Genome Epidemiology (HuGE) Navigator
HS3ST5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HS3ST5
genes like me logo Genes that share disorders with HS3ST5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HS3ST5 Gene

Publications for HS3ST5 Gene

  1. Heparan sulfate 3-O-sulfotransferase isoform 5 generates both an antithrombin-binding site and an entry receptor for herpes simplex virus, type 1. (PMID: 12138164) Xia G. … Liu J. (J. Biol. Chem. 2002) 2 3 4 22 64
  2. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PMID: 18978678) Vieira A.R. … Marazita M.L. (Genet. Med. 2008) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The biosynthesis of anticoagulant heparan sulfate by the heparan sulfate 3-O-sulfotransferase isoform 5. (PMID: 15026143) Duncan M.B. … Liu J. (Biochim. Biophys. Acta 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for HS3ST5 Gene

Sources for HS3ST5 Gene

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