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Aliases for HS3ST4 Gene

Aliases for HS3ST4 Gene

  • Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 4 2 3
  • Heparan Sulfate D-Glucosaminyl 3-O-Sulfotransferase 4 3 4
  • Heparan Sulfate 3-O-Sulfotransferase 4 3 4
  • H3-OST-4 3 4
  • 3-OST-4 3 4
  • 30ST4 3 6
  • 3OST4 3 4
  • Heparan Sulfate Glucosamine 3-O-Sulfotransferase 4 3
  • Heparan Sulfate 3-O-Sulfotransferase-4 3
  • EC 2.8.2.23 4
  • EC 2.8.2 63

External Ids for HS3ST4 Gene

Previous GeneCards Identifiers for HS3ST4 Gene

  • GC16P025131
  • GC16P025802
  • GC16P025631
  • GC16P025669
  • GC16P025610
  • GC16P023796

Summaries for HS3ST4 Gene

Entrez Gene Summary for HS3ST4 Gene

  • This gene encodes the enzyme heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4. This enzyme generates 3-O-sulfated glucosaminyl residues in heparan sulfate. Cell surface heparan sulfate is used as a receptor by herpes simplex virus type 1 (HSV-1), and expression of this gene is thought to play a role in HSV-1 pathogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for HS3ST4 Gene

HS3ST4 (Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 4) is a Protein Coding gene. Diseases associated with HS3ST4 include herpes simplex. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. An important paralog of this gene is NDST4.

UniProtKB/Swiss-Prot for HS3ST4 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HS3ST4 Gene

Genomics for HS3ST4 Gene

Regulatory Elements for HS3ST4 Gene

Genomic Location for HS3ST4 Gene

Start:
25,692,026 bp from pter
End:
26,137,688 bp from pter
Size:
445,663 bases
Orientation:
Plus strand

Genomic View for HS3ST4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HS3ST4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HS3ST4 Gene

Proteins for HS3ST4 Gene

  • Protein details for HS3ST4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y661-HS3S4_HUMAN
    Recommended name:
    Heparan sulfate glucosamine 3-O-sulfotransferase 4
    Protein Accession:
    Q9Y661
    Secondary Accessions:
    • Q5QI42
    • Q8NDC2

    Protein attributes for HS3ST4 Gene

    Size:
    456 amino acids
    Molecular mass:
    49799 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HS3ST4 Gene

Proteomics data for HS3ST4 Gene at MOPED

Selected DME Specific Peptides for HS3ST4 Gene

Post-translational modifications for HS3ST4 Gene

  • Glycosylation at Asn105, Asn178, Asn318, and Asn389

Other Protein References for HS3ST4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for HS3ST4 Gene

Gene Families for HS3ST4 Gene

HGNC:
  • SULTM :Sulfotransferases, membrane-bound

Protein Domains for HS3ST4 Gene

Suggested Antigen Peptide Sequences for HS3ST4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y661

UniProtKB/Swiss-Prot:

HS3S4_HUMAN :
  • Q9Y661
Family:
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with HS3ST4: view

Function for HS3ST4 Gene

Molecular function for HS3ST4 Gene

GENATLAS Biochemistry: heparan sulfate D-glucosamine 3-O-sulfotransferase 4,putative regulator of heparan sulfate proteoglycan properties
UniProtKB/Swiss-Prot CatalyticActivity: 3-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3,5-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate
UniProtKB/Swiss-Prot Function: Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity).

Enzyme Numbers (IUBMB) for HS3ST4 Gene

Gene Ontology (GO) - Molecular Function for HS3ST4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008146 sulfotransferase activity --
GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity NAS 9988767
genes like me logo Genes that share ontologies with HS3ST4: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HS3ST4 Gene

Localization for HS3ST4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HS3ST4 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HS3ST4 Gene COMPARTMENTS Subcellular localization image for HS3ST4 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
mitochondrion 2
cytosol 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HS3ST4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HS3ST4: view

Pathways for HS3ST4 Gene

genes like me logo Genes that share pathways with HS3ST4: view

Interacting Proteins for HS3ST4 Gene

Gene Ontology (GO) - Biological Process for HS3ST4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030201 heparan sulfate proteoglycan metabolic process NAS 9988767
genes like me logo Genes that share ontologies with HS3ST4: view

Compounds for HS3ST4 Gene

(1) HMDB Compounds for HS3ST4 Gene

Compound Synonyms Cas Number PubMed IDs
Iduronic acid
  • L-Iduronate
3402-98-0
genes like me logo Genes that share compounds with HS3ST4: view

Transcripts for HS3ST4 Gene

mRNA/cDNA for HS3ST4 Gene

Unigene Clusters for HS3ST4 Gene

Heparan sulfate (glucosamine) 3-O-sulfotransferase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HS3ST4 Gene

No ASD Table

Relevant External Links for HS3ST4 Gene

GeneLoc Exon Structure for
HS3ST4
ECgene alternative splicing isoforms for
HS3ST4

Expression for HS3ST4 Gene

mRNA expression in normal human tissues for HS3ST4 Gene

mRNA differential expression in normal tissues according to GTEx for HS3ST4 Gene

This gene is overexpressed in Brain - Cortex (8.3), Brain - Frontal Cortex (BA9) (6.1), Brain - Hippocampus (5.8), Brain - Anterior cingulate cortex (BA24) (5.7), and Brain - Hypothalamus (4.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for HS3ST4 Gene

SOURCE GeneReport for Unigene cluster for HS3ST4 Gene Hs.655275

mRNA Expression by UniProt/SwissProt for HS3ST4 Gene

Q9Y661-HS3S4_HUMAN
Tissue specificity: Brain-specific.
genes like me logo Genes that share expressions with HS3ST4: view

Orthologs for HS3ST4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HS3ST4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HS3ST4 35
  • 99.68 (n)
  • 99.52 (a)
cow
(Bos Taurus)
Mammalia HS3ST4 35
  • 94.74 (n)
  • 99.04 (a)
dog
(Canis familiaris)
Mammalia HS3ST4 35
  • 91.92 (n)
  • 91.22 (a)
mouse
(Mus musculus)
Mammalia Hs3st4 35
  • 86.59 (n)
  • 89.88 (a)
Hs3st4 16
Hs3st4 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC691700 35
  • 87.92 (n)
  • 93.12 (a)
chicken
(Gallus gallus)
Aves HS3ST4 35
  • 82.52 (n)
  • 91.61 (a)
HS3ST4 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 75 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492416 35
  • 74.59 (n)
  • 82.81 (a)
zebrafish
(Danio rerio)
Actinopterygii hs3st4 35
  • 67.76 (n)
  • 70.28 (a)
hs3st4 36
  • 66 (a)
OneToOne
Species with no ortholog for HS3ST4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HS3ST4 Gene

ENSEMBL:
Gene Tree for HS3ST4 (if available)
TreeFam:
Gene Tree for HS3ST4 (if available)

Paralogs for HS3ST4 Gene

Selected SIMAP similar genes for HS3ST4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HS3ST4: view

Variants for HS3ST4 Gene

Sequence variations from dbSNP and Humsavar for HS3ST4 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs2618 -- 26,004,526(+) AAGCA(A/G)GCACT intron-variant
rs2619 -- 26,004,471(+) AGAAA(A/T)AAAGG intron-variant
rs1399338 -- 25,691,581(-) TCGCC(C/T)GGGAT upstream-variant-2KB
rs2861170 -- 26,098,033(-) ggtat(C/T)tcatt intron-variant
rs2881210 -- 25,705,090(+) TTATT(A/C)CTGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HS3ST4 Gene

Variant ID Type Subtype PubMed ID
dgv841e1 CNV Complex 17122850
esv2714126 CNV Deletion 23290073
esv2714127 CNV Deletion 23290073
esv2714128 CNV Deletion 23290073
esv989105 CNV Deletion 20482838
esv1614178 CNV Deletion 17803354
nsv9407 CNV Loss 18304495
esv2666037 CNV Deletion 23128226
nsv521162 CNV Gain 19592680
esv2714130 CNV Deletion 23290073
esv8601 CNV Gain 19470904
esv269084 CNV Insertion 20981092
dgv164n21 CNV Loss 19592680
nsv519437 CNV Loss 19592680
esv2714131 CNV Deletion 23290073
esv271094 CNV Insertion 20981092
nsv507811 CNV Insertion 20534489

Relevant External Links for HS3ST4 Gene

HapMap Linkage Disequilibrium report
HS3ST4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HS3ST4 Gene

Disorders for HS3ST4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for HS3ST4 Gene including...

Search for HS3ST4 Gene in MalaCards »

Relevant External Links for HS3ST4

Genetic Association Database (GAD)
HS3ST4
Human Genome Epidemiology (HuGE) Navigator
HS3ST4
genes like me logo Genes that share disorders with HS3ST4: view

No data available for UniProtKB/Swiss-Prot for HS3ST4 Gene

Publications for HS3ST4 Gene

  1. Multiple isoforms of heparan sulfate D-glucosaminyl 3-O- sulfotransferase. Isolation, characterization, and expression of human cDNAs and identification of distinct genomic loci. (PMID: 9988767) Shworak N.W. … Rosenberg R.D. (J. Biol. Chem. 1999) 2 3 4 23
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  4. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. (PMID: 24324551) Deng X. … Seielstad M. (PLoS ONE 2013) 3
  5. A second-generation genomewide screen for asthma-susceptibility alleles in a founder population. (PMID: 11022011) Ober C. … Cox N.J. (Am. J. Hum. Genet. 2000) 48

Products for HS3ST4 Gene

Sources for HS3ST4 Gene

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