Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HS3ST4 Gene

protein-coding   GIFtS: 50
GCID: GC16P025610

Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 4

  See HS3ST4-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 41 2     30ST42 5
Heparan Sulfate 3-O-Sulfotransferase 42 3     Heparan Sulfate 3-O-Sulfotransferase-42
Heparan Sulfate D-Glucosaminyl 3-O-Sulfotransferase 42 3     Heparan Sulfate Glucosamine 3-O-Sulfotransferase 42
3-OST-42 3     EC 2.8.2.233
3OST42 3     EC 2.8.28
h3-OST-42 3     

External Ids:    HGNC: 52001   Entrez Gene: 99512   Ensembl: ENSG000001826017   OMIM: 6040595   UniProtKB: Q9Y6613   

Export aliases for HS3ST4 gene to outside databases

Previous GC identifers: GC16P025131 GC16P025802 GC16P025631 GC16P025669 GC16P023796


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for HS3ST4 Gene:
This gene encodes the enzyme heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4. This enzyme generates
3-O-sulfated glucosaminyl residues in heparan sulfate. Cell surface heparan sulfate is used as a receptor by
herpes simplex virus type 1 (HSV-1), and expression of this gene is thought to play a role in HSV-1 pathogenesis.
(provided by RefSeq, Jul 2008)

GeneCards Summary for HS3ST4 Gene:
HS3ST4 (heparan sulfate (glucosamine) 3-O-sulfotransferase 4) is a protein-coding gene. Diseases associated with HS3ST4 include herpes simplex. GO annotations related to this gene include [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. An important paralog of this gene is HS3ST2.

UniProtKB/Swiss-Prot: HS3S4_HUMAN, Q9Y661
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo
group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Unlike
3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_187260.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the HS3ST4 gene promoter:
         AhR   p300   C/EBPalpha   AREB6   CHOP-10   HSF2   FOXJ2 (long isoform)   HOXA5   FOXJ2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHS3ST4 promoter sequence
   Search Chromatin IP Primers for HS3ST4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HS3ST4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p12.1   HGNC cytogenetic band: 16p11.2

HS3ST4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HS3ST4 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P025610:  view genomic region     (about GC identifiers)

Start:
25,703,347 bp from pter      End:
26,149,009 bp from pter
Size:
445,663 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: HS3S4_HUMAN, Q9Y661 (See protein sequence)
Recommended Name: Heparan sulfate glucosamine 3-O-sulfotransferase 4  
Size: 456 amino acids; 49799 Da
Secondary accessions: Q5QI42 Q8NDC2

Explore the universe of human proteins at neXtProt for HS3ST4: NX_Q9Y661

Explore proteomics data for HS3ST4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn105, Asn178, Asn318, Asn389
  • Selected DME Specific Peptides for HS3ST4 (Q9Y661) (see all 7)
     EPHFFDR  TKGFPCLKK  FYFNKTKGF  KGGTRALLE 


    See HS3ST4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006031.2  
    ENSEMBL proteins: 
     ENSP00000330606  
    Reactome Protein details: Q9Y661

    HS3ST4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for HS3ST4 (Heparan Sulfate 3-O-Sulfotransferase 4/HS3ST4)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for HS3ST4
    GenScript Custom Purified and Recombinant Proteins Services for HS3ST4
    Novus Biologicals HS3ST4 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HS3ST4

     
    Search eBioscience for Proteins for HS3ST4 

    HS3ST4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for HS3ST4 (Heparan Sulfate 3-O-Sulfotransferase 4/HS3ST4)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HS3ST4
    Search for Antibodies for HS3ST4 at Abcam
    Cloud-Clone Corp. Antibodies for HS3ST4
    Search ThermoFisher Antibodies for HS3ST4
    LSBio Antibodies in human, mouse, rat for HS3ST4

    HS3ST4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HS3ST4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HS3ST4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HS3ST4
    Cloud-Clone Corp. CLIAs for HS3ST4
    Search eBioscience for ELISAs for HS3ST4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SULTM: Sulfotransferases, membrane-bound

    2 InterPro protein domains:
     IPR000863 Sulfotransferase_dom
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q9Y661

    ProtoNet protein and cluster: Q9Y661

    UniProtKB/Swiss-Prot: HS3S4_HUMAN, Q9Y661
    Similarity: Belongs to the sulfotransferase 1 family


    Find genes that share domains with HS3ST4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HS3S4_HUMAN, Q9Y661
    Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo
    group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Unlike
    3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity)
    Catalytic activity: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate +
    [heparan sulfate]-glucosamine 3-sulfate

         Genatlas biochemistry entry for HS3ST4:
    heparan sulfate D-glucosamine 3-O-sulfotransferase 4,putative regulator of heparan sulfate proteoglycan properties

         Enzyme Numbers (IUBMB): EC 2.8.2.231 EC 2.8.22

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008146sulfotransferase activity ----
    GO:0008467[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity NAS9988767
         
    Find genes that share ontologies with HS3ST4           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HS3ST4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HS3ST4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HS3ST4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HS3ST4

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat HS3ST4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HS3ST4 (see all 38):
    hsa-miR-579 hsa-miR-100* hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-4254 hsa-miR-485-3p hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidHS3ST4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HS3ST4
    Predesigned siRNA for gene silencing in human, mouse, rat HS3ST4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HS3ST4

    Clone
    Products:
         
    OriGene clones in human, mouse for HS3ST4 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HS3ST4 (NM_006040)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HS3ST4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HS3ST4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HS3ST4
    Browse ESI BIO Cell Lines and PureStem Progenitors for HS3ST4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HS3ST4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    HS3S4_HUMAN, Q9Y661: Golgi apparatus membrane; Single-pass type II membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    golgi apparatus5
    mitochondrion2
    cytosol1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005576extracellular region ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with HS3ST4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for HS3ST4 About   (see all 7)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIIB - Sanfilippo syndrome B0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS II - Hunter syndrome0.45
    MPS IV - Morquio syndrome A0.45
    Glycosaminoglycan metabolism0.45
    Mucopolysaccharidoses0.45
    MPS IV - Morquio syndrome B0.45
    2heparan sulfate biosynthesis
    heparan sulfate biosynthesis0.79
    heparan sulfate biosynthesis (late stages)0.00
    3Heparan sulfate/heparin (HS-GAG) metabolism
    Heparan sulfate/heparin (HS-GAG) metabolism0.57
    HS-GAG biosynthesis0.57
    4Biological oxidations
    metapathway biotransformation0.42
    5Metabolism
    Metabolism0.38


    Find genes that share SuperPaths with HS3ST4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for HS3ST4
        Articular Cartilage Extracellular Matrix


    3 BioSystems Pathways for HS3ST4
        heparan sulfate biosynthesis (late stages)
    metapathway biotransformation
    heparan sulfate biosynthesis

    1 Reactome Pathway for HS3ST4
        HS-GAG biosynthesis


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HS3ST4
    Interactions:

        Search GeneGlobe Interaction Network for HS3ST4

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030201heparan sulfate proteoglycan metabolic process NAS9988767

    Find genes that share ontologies with HS3ST4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HS3ST4 (HS3S4)

    1 HMDB Compound for HS3ST4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Iduronic acidL-Iduronate (see all 3)3402-98-0--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for HS3ST4 gene: 
    NM_006040.2  

    Unigene Cluster for HS3ST4:

    Heparan sulfate (glucosamine) 3-O-sulfotransferase 4
    Hs.655275  [show with all ESTs]
    Unigene Representative Sequence: NM_006040
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000331351(uc002dof.3) ENST00000475436
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HS3ST4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HS3ST4 (see all 38):
    hsa-miR-579 hsa-miR-100* hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-4254 hsa-miR-485-3p hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidHS3ST4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HS3ST4
    Predesigned siRNA for gene silencing in human, mouse, rat HS3ST4
    Clone
    Products:
         
    OriGene clones in human, mouse for HS3ST4 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HS3ST4 (NM_006040)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HS3ST4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HS3ST4
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for HS3ST4
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HS3ST4
      QuantiTect SYBR Green Assays in human, mouse, rat HS3ST4
      QuantiFast Probe-based Assays in human, mouse, rat HS3ST4

    Additional mRNA sequence: 

    AF105378.2 AL834283.1 EF063601.1 EF063602.1 EF063603.1 EF063604.1 EF063605.1 EF063606.1 
    EF063607.1 EF063608.1 

    1 DOTS entry:

    DT.111189 

    Selected AceView cDNA sequences (see all 42):

    F10682 AA639141 CB154928 BU741565 AA776654 AA317840 AW136756 BM727888 
    T33472 F13088 BE328142 AL834283 BF433598 AA973808 BX478504 AW138589 
    AW204697 BP429181 NM_006040 AW204561 BE674045 BI752684 AF105378 AA724994 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    HS3ST4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HS3ST4 Expression
    About this image


    HS3ST4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
    HS3ST4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HS3ST4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655275

    UniProtKB/Swiss-Prot: HS3S4_HUMAN, Q9Y661
    Tissue specificity: Brain-specific

        Custom PCR Arrays for HS3ST4
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for HS3ST4
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HS3ST4
    QuantiTect SYBR Green Assays in human, mouse, rat HS3ST4
    QuantiFast Probe-based Assays in human, mouse, rat HS3ST4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HS3ST4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for HS3ST4 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hs3st41 , 5 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 less1, 5 86.59(n)1
    89.88(a)1
      7 (67.56 cM)5
    6287791  NM_001252072.11  NP_001239001.11 
     1239828695 
    chicken
    (Gallus gallus)
    Aves HS3ST41 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 less 82.52(n)
    91.61(a)
      427674  XM_425248.4  XP_425248.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    75(a)
    many ↔ many
    GL343263.1(1397603-1398217)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004924161 serine-rich adhesin for platelets-like 74.59(n)
    82.81(a)
      100492416  XM_002931989.2  XP_002932035.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hs3st41 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 less 67.76(n)
    70.28(a)
      563570  NM_001080589.1  NP_001074058.1 


    ENSEMBL Gene Tree for HS3ST4 (if available)
    TreeFam Gene Tree for HS3ST4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for HS3ST4 gene
    HS3ST22  NDST22  ENSG000002729162  HS3ST12  HS3ST3B12  HS3ST62  HS3ST3A12  HS3ST52  
    NDST12  NDST42  NDST32  
    9 SIMAP similar genes for HS3ST4 using alignment to 2 protein entries:     HS3S4_HUMAN (see all proteins):
    HS3ST3A1    HS3ST2    HS3ST6    HS3ST3B1    HS3ST1    HS3ST5
    NDST1    NDST4    NDST2

    Find genes that share paralogs with HS3ST4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for HS3ST4 (see all 9869)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1828657831,2
    --25701571(+) AAACTA/GGGCAT 1 -- us2k10--------
    rs802149871,2
    C,F--25701907(+) GACTCC/TGCATT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1511544881,2
    --25702144(+) TTTTCC/TTATTA 1 -- us2k10--------
    rs1872533091,2
    --25702170(+) CCAGAA/GATGCC 1 -- us2k10--------
    rs799163641,2
    C,F--25702493(+) AAAATA/TCACTT 1 -- us2k13Minor allele frequency- T:0.04CSA WA 122
    rs1390458141,2
    --25702614(+) AACTCC/TGTTAG 1 -- us2k10--------
    rs740148211,2
    C,F--25702813(+) GGGCGG/CGGGGC 1 -- us2k13Minor allele frequency- C:0.07WA NA 240
    rs799999761,2
    C--25702896(+) GAGGAC/TATCCC 1 -- us2k10--------
    rs13993381,2
    C,F,H--25702902(-) TCGCCC/TGGGAT 1 -- us2k118Minor allele frequency- T:0.21MN NS EA NA WA 2516
    rs711589621,2
    C--25703137(+) GGGGGG/-CTGGG 1 -- us2k12Minor allele frequency- -:0.25NA CSA 4

    HapMap Linkage Disequilibrium report for HS3ST4 (25703347 - 25953347 bp, first 250kb of HS3ST4)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HS3ST4 (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2714130CNV Deletion23290073
    esv989105CNV Deletion20482838
    esv2714128CNV Deletion23290073
    esv2714127CNV Deletion23290073
    esv2666037CNV Deletion23128226
    esv2714131CNV Deletion23290073
    esv1614178CNV Deletion17803354
    esv2714126CNV Deletion23290073
    nsv507811CNV Insertion20534489
    esv269084CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HS3ST4
    DNA2.0 Custom Variant and Variant Library Synthesis for HS3ST4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604059    OMIM disorders: --

    1 disease for HS3ST4:    
    About MalaCards
    herpes simplex


    Find genes that share disorders with HS3ST4           About GenesLikeMe

    Genetic Association Database (GAD): HS3ST4
    Human Genome Epidemiology (HuGE) Navigator: HS3ST4 (2 documents)

    Export disorders for HS3ST4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for HS3ST4 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with HS3ST4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Multiple isoforms of heparan sulfate D-glucosaminyl 3-O- sulfotransferase. Isolation, characterization, and expression of human cDNAs and identification of distinct genomic loci. (PubMed id 9988767)1, 2, 3, 9 Shworak N.W.... Rosenberg R.D. (J. Biol. Chem. 1999)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    4. Tetrasulfated disaccharide unit in heparan sulfate: enzymatic formation and tissue distribution. (PubMed id 18757372)1 Mochizuki H....Kimata K. (J. Biol. Chem. 2008)
    5. The principal neuronal gD-type 3-O-sulfotransferases and their products in central and peripheral nervous system tissues. (PubMed id 17482450)1 Lawrence R....Shworak N.W. (Matrix Biol. 2007)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    7. A role for 3-O-sulfotransferase isoform-4 in assisting HSV-1 entry and spread. (PubMed id 16259945)1 Tiwari V....Shukla D. (Biochem. Biophys. Res. Commun. 2005)
    8. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (Nature 2004)
    9. Characterization of a heparan sulfate octasaccharide that binds to herpes simplex virus type 1 glycoprotein D. (PubMed id 12080045)1 Liu J....Sasisekharan R. (J. Biol. Chem. 2002)
    10. A second-generation genomewide screen for asthma-susceptibility alleles in a founder population. (PubMed id 11022011)4 Ober C....Cox N.J. (Am. J. Hum. Genet. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9951 HGNC: 5200 AceView: HS3ST4 Ensembl:ENSG00000182601 euGenes: HUgn9951
    ECgene: HS3ST4 H-InvDB: HS3ST4

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for HS3ST4 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=HS3ST4

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for HS3ST4 gene:
    Search GeneIP for patents involving HS3ST4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for HS3ST4 (Heparan Sulfate 3-O-Sulfotransferase 4/HS3ST4)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for HS3ST4 (Heparan Sulfate 3-O-Sulfotransferase 4/HS3ST4)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for HS3ST4  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for HS3ST4  
     OriGene qSTAR qPCR primer pairs in human, mouse for HS3ST4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HS3ST4   OriGene Custom Protein Services for HS3ST4  

     
     
     Block miRNA regulation of human, mouse, rat HS3ST4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HS3ST4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HS3ST4 Predesigned siRNA for gene silencing in human, mouse, rat HS3ST4
     QuantiFast Probe-based Assays in human, mouse, rat HS3ST4 QuantiTect SYBR Green Assays in human, mouse, rat HS3ST4
     Custom PCR Arrays for HS3ST4 Search Chromatin IP Primers for HS3ST4
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HS3ST4  Search GeneGlobe Interaction Network for HS3ST4
     Regulatory tfbs in HS3ST4 promoter
     GenScript Custom Purified and Recombinant Proteins Services for HS3ST4 GenScript cDNA clones with any tag delivered in your preferred vector for HS3ST4
     GenScript Custom Assay Services for HS3ST4 GenScript Custom overexpressing Cell Line Services for HS3ST4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for HS3ST4 (HS3S4)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     HS3ST4 proteins
     Search for Antibodies for HS3ST4 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for HS3ST4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for HS3ST4
     Antibodies for HS3ST4
     ELISAs for HS3ST4
     CLIAs for HS3ST4



     Browse ESI BIO Cell Lines and PureStem Progenitors for HS3ST4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HS3ST4
     SwitchGear 3'UTR luciferase reporter plasmids for HS3ST4
     SwitchGear Promoter luciferase reporter plasmids for HS3ST4
     Search ThermoFisher Antibodies for HS3ST4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HS3ST4
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HS3ST4
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HS3ST4
     LSBio Antibodies in human, mouse, rat for HS3ST4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for HS3ST4
      Search eBioscience for proteins for HS3ST4
      Search eBioscience for elisas for HS3ST4
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HS3ST4 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4