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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HS3ST4 Gene

protein-coding GIFtS: 50
GCID: GC16P025610

heparan sulfate (glucosamine) 3-O-sulfotransferase 4

Explore 2 diseases affiliated with
HS3ST4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 4¹ ²		30ST4² ⁵
3OST4¹ ² ³		Heparan Sulfate 3-O-Sulfotransferase-4²
Heparan Sulfate 3-O-Sulfotransferase 4² ³		Heparan Sulfate Glucosamine 3-O-Sulfotransferase 4²
Heparan Sulfate D-Glucosaminyl 3-O-Sulfotransferase 4² ³		EC 2.8.2.23³
3-OST-4² ³		EC 2.8.2⁸
H3-OST-4¹

External Ids:	HGNC: 5200¹	Entrez Gene: 9951²	Ensembl: ENSG00000182601⁷	OMIM: 604059⁵	UniProtKB: Q9Y661³

Export aliases for HS3ST4 gene to outside databases

Previous GC identifers: GC16P025131 GC16P025802 GC16P025631 GC16P025669 GC16P023796

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HS3ST4:

This gene encodes the enzyme heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4. This enzyme generates 3-O-sulfated

glucosaminyl residues in heparan sulfate. Cell surface heparan sulfate is used as a receptor by herpes simplex virus

type 1 (HSV-1), and expression of this gene is thought to play a role in HSV-1 pathogenesis. (provided by RefSeq, Jul

2008)

UniProtKB/Swiss-Prot: HS3S4_HUMAN, Q9Y661

Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo

group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Unlike 3-OST-1,

does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HS3ST4 gene promoter:
AhR p300 C/EBPalpha AREB6 CHOP-10 HSF2 FOXJ2 (long isoform) HOXA5 FOXJ2 Ik-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HS3ST4 promoter sequence

Search SABiosciences Chromatin IP Primers for HS3ST4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HS3ST4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p12.1 HGNC cytogenetic band: 16p11.2

HS3ST4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HS3ST4 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P025610: view genomic region (about GC identifiers)

Start:	25,703,347 bp from pter	End:	26,149,009 bp from pter
Size:	445,663 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HS3S4_HUMAN, Q9Y661 (See protein sequence)

Recommended Name: Heparan sulfate glucosamine 3-O-sulfotransferase 4

Size: 456 amino acids; 49826 Da

Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (Probable)

Secondary accessions: Q5QI42 Q8NDC2

Explore the universe of human proteins at neXtProt for HS3ST4: NX_Q9Y661

4/7 DME Specific Peptides for HS3ST4 (Q9Y661) (see all 7)

EPHFFDR

TKGFPCLKK

FYFNKTKGF

KGGTRALLE

HS3ST4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006031.2

ENSEMBL proteins:

ENSP00000330606

Reactome Protein details: Q9Y661
Human Recombinant Protein Products for HS3ST4:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals HS3ST4 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for HS3ST4

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IEA	--
GO:0005576	extracellular region	NAS	--
GO:0016021	integral to membrane	IEA	--

HS3ST4 for ontologies About GeneDecksing

HS3ST4 Antibody Products:

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Assay Products for HS3ST4:

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	Uscn ELISAs and CLIAs for HS3ST4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HS3ST4 for domains About GeneDecksing

1 InterPro domain/family:

IPR000863 Sulfotransferase_dom

Graphical View of Domain Structure for InterPro Entry Q9Y661

ProtoNet protein and cluster: Q9Y661

UniProtKB/Swiss-Prot: HS3S4_HUMAN, Q9Y661

Similarity: Belongs to the sulfotransferase 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: HS3S4_HUMAN, Q9Y661

Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo

group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Unlike 3-OST-1,

does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity)

Catalytic activity: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate +

[heparan sulfate]-glucosamine 3-sulfate

Genatlas biochemistry entry for HS3ST4:

heparan sulfate D-glucosamine 3-O-sulfotransferase 4,putative regulator of heparan sulfate proteoglycan properties

Enzyme Numbers (IUBMB): EC 2.8.2.23¹ EC 2.8.2²

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity	NAS	9988767

HS3ST4 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HS3ST4

miRNA Products:		OriGene 3'-UTR Clone: HS3ST4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HS3ST4
		8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate HS3ST4 (see all 38):
		hsa-miR-579 hsa-miR-100* hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-4254 hsa-miR-485-3p hsa-miR-29b-1*

		SwitchGear 3'UTR luciferase reporter plasmid: HS3ST4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HS3ST4 OriGene shRNA RFP: HS3ST4 OriGene siRNA: HS3ST4
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		Sirion Biotech Custom design and validation of potent shRNA sequences against HS3ST4

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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HS3ST4 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HS3ST4 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HS3ST4 (NM_006040)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HS3ST4

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

MPS IIIC - Sanfilippo syndrome C

8/16 pathways (see all 16)
MPS VI - Maroteaux-Lamy syndrome	1.00	MPS IIIA - Sanfilippo syndrome A	1.00
MPS IIIC - Sanfilippo syndrome C	1.00	MPS IIID - Sanfilippo syndrome D	1.00
MPS I - Hurler syndrome	1.00	MPS IX - Natowicz syndrome	1.00
Mucopolysaccharidoses	1.00	MPS II - Hunter syndrome	1.00

heparan sulfate biosynthesis

heparan sulfate biosynthesis

1.00

heparan sulfate biosynthesis (late stages)

0.78

Disease

Disease

1.00

Metabolism

Metabolism

1.00

Articular Cartilage Extracellular Matrix

Articular Cartilage Extracellular Matrix

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 R&D Systems Pathway for HS3ST4

Articular Cartilage Extracellular Matrix

3 BioSystems Pathways for HS3ST4

	heparan sulfate biosynthesis (late stages)
	metapathway biotransformation
	heparan sulfate biosynthesis

5/18 Reactome Pathways for HS3ST4 (see all 18)

	MPS VI - Maroteaux-Lamy syndrome
	Metabolism
	Disease
	HS-GAG biosynthesis
	MPS II - Hunter syndrome

HS3ST4 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for HS3ST4

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0030201	heparan sulfate proteoglycan metabolic process	NAS	9988767

HS3ST4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HS3ST4

1 HMDB Compound for HS3ST4 About this table

Compound	Synonyms	CAS #	PubMed Ids
Iduronic acid	L-Iduronate (see all 3)	3402-98-0	--

Search CenterWatch for drugs/clinical trials and news about HS3ST4 / HS3S4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HS3ST4 gene:

NM_006040.2

Unigene Cluster for HS3ST4:

Heparan sulfate (glucosamine) 3-O-sulfotransferase 4

Hs.655275 [show with all ESTs]

Unigene Representative Sequence: NM_006040

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000331351(uc002dof.3) ENST00000475436

miRNA Products:		OriGene 3'-UTR Clone: HS3ST4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HS3ST4
		8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate HS3ST4 (see all 38):
		hsa-miR-579 hsa-miR-100* hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-4254 hsa-miR-485-3p hsa-miR-29b-1*

		SwitchGear 3'UTR luciferase reporter plasmid: HS3ST4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HS3ST4 OriGene shRNA RFP: HS3ST4 OriGene siRNA: HS3ST4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HS3ST4
		Sirion Biotech Custom design and validation of potent shRNA sequences against HS3ST4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HS3ST4 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HS3ST4 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HS3ST4 (NM_006040)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HS3ST4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HS3ST4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HS3ST4 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HS3ST4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HS3ST4

Additional cDNA sequence:

AF105378.2 AL834283.1 EF063601.1 EF063602.1 EF063603.1 EF063604.1 EF063605.1 EF063606.1

EF063607.1 EF063608.1

1 DOTS entry:

DT.111189

24/42 AceView cDNA sequences (see all 42):

BU741565 BE328142 F13088 AA317840 AW136756 BM727888 CB154928 AL834283

F10682 AA639141 T33472 AA776654 AA724994 BE674045 BI752684 AI825533

AA973808 AW205326 BP429181 BX478504 NM_006040 AW204697 AF105378 AW138589

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HS3ST4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

HS3ST4 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

9 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Spinal Cord

Spinal Dorsal Columns

Dorsal Spinal Cord Progenitor Cells

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Brain

Brain

Brain

Neural Tube

Neural Tube

Spinal Dorsal Columns

Spinal Cord

Spinal Ventral Columns

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

See HS3ST4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HS3ST4

SOURCE GeneReport for Unigene cluster: Hs.655275

UniProtKB/Swiss-Prot: HS3S4_HUMAN, Q9Y661

Tissue specificity: Brain-specific

SABiosciences Custom PCR Arrays for HS3ST4

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HS3ST4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HS3ST4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for HS3ST4 gene from 4/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	HS3ST4¹	heparan sulfate (glucosamine) 3-O-sulfotransferase 4 less	82.52(n) 91.61(a)		427674 XM_425248.3 XP_425248.3
zebrafish (Danio rerio)	Actinopterygii	hs3st4¹	heparan sulfate (glucosamine) 3-O-sulfotransferase 4 less	68.82(n) 73.39(a)		563570 NM_001080589.1 NP_001074058.1
fruit fly (Drosophila melanogaster)	Insecta	Hs3st-B⁶	Heparan sulfate 3-O sulfotransferase-B	47(a)	1 → many	X(19143021-19146078)
worm (Caenorhabditis elegans)	Secernentea	hst-3.2⁶ hst-1⁶	Heparan SulphoTransferase family member (hst-3.2) Bifunctional heparan sulfate N-deacetylase/N-sulfo...	45(a) 11(a)	1 ↔ many possible ortholog	X(2918795-2923974) IV(8688260-8691500)

ENSEMBL Gene Tree for HS3ST4 (if available)
TreeFam Gene Tree for HS3ST4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HS3ST4 gene

HS3ST2² HS3ST1² NDST2² HS3ST3B1² HS3ST6² HS3ST3A1² HS3ST5² NDST1²

NDST3² NDST4²

9 SIMAP similar genes for HS3ST4 using alignment to 2 protein entries: HS3S4_HUMAN (see all proteins):

HS3ST3A1 HS3ST2 HS3ST6 HS3ST3B1 HS3ST1 HS3ST5

NDST1 NDST4 NDST2

HS3ST4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs182865783^1,2		--	25701571(+)	`AAACTA/GGGCAT`	1	--	us2k¹		0	--	--	--	--
rs80214987^1,2		--	25701907(+)	`GACTCC/TGCATT`	1	--	us2k¹		1		CSA	2
rs151154488^1,2		--	25702144(+)	`TTTTCC/TTATTA`	1	--	us2k¹		0	--	--	--	--
rs187253309^1,2		--	25702170(+)	`CCAGAA/GATGCC`	1	--	us2k¹		0	--	--	--	--
rs79916364^1,2	F	--	25702493(+)	`AAAATA/TCACTT`	1	--	us2k¹		3		CSA WA	122
rs139045814^1,2		--	25702614(+)	`AACTCC/TGTTAG`	1	--	us2k¹		0	--	--	--	--
rs74014821^1,2	C	--	25702813(+)	`GGGCGG/CGGGGC`	1	--	us2k¹		3		WA NA	240
rs79999976^1,2		--	25702896(+)	`GAGGAC/TATCCC`	1	--	us2k¹		0	--	--	--	--
rs1399338^1,2	C,F,H	--	25702902(-)	`TCGCCC/TGGGAT`	1	--	us2k¹		18		MN NS EA NA WA	2516
rs113742730^1,2	C	--	25703137(+)	`GTGCTG/-GGGGG`	1	--	us2k¹		1		CSA	2

HapMap Linkage Disequilibrium report for HS3ST4 (25703347 - 25953347 bp, first 250kb of HS3ST4)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for HS3ST4
2 CNVs: 49678 3998
2 Indels: 60198 33624

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HS3ST4

DNA2.0 Custom Variant and Variant Library Synthesis for HS3ST4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HS3ST4 for disorders           About GeneDecksing

OMIM gene information: 604059    OMIM disorders: --

2 diseases for HS3ST4:    About MalaCards

herpes simplex neuronitis

Human Genome Epidemiology (HuGE) Navigator: HS3ST4 (2 documents)

Export disorders for HS3ST4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for HS3ST4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with HS3ST4)

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Multiple isoforms of heparan sulfate D-glucosaminyl 3-O- sulfotransferase. Isolation, characterization, and expression of human cDNAs and identification of distinct genomic loci. (PubMed id 9988767)^{1, 2, 3, 9} Shworak N.W.... Rosenberg R.D. (1999)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Tetrasulfated disaccharide unit in heparan sulfate: enzymatic formation and tissue distribution. (PubMed id 18757372)¹ Mochizuki H....Kimata K. (2008)
The principal neuronal gD-type 3-O-sulfotransferases and their products in central and peripheral nervous system tissues. (PubMed id 17482450)¹ Lawrence R....Shworak N.W. (2007)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
A role for 3-O-sulfotransferase isoform-4 in assisting HSV-1 entry and spread. (PubMed id 16259945)¹ Tiwari V....Shukla D. (2005)
Characterization of a heparan sulfate octasaccharide that binds to herpes simplex virus type 1 glycoprotein D. (PubMed id 12080045)¹ Liu J....Sasisekharan R. (2002)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9951	HGNC: 5200	AceView: HS3ST4	Ensembl:ENSG00000182601	euGenes: HUgn9951
ECgene: HS3ST4	H-InvDB: HS3ST4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for HS3ST4	Pharmacogenomics, SNPs, Pathways
GGDB	http://riodb.ibase.aist.go.jp/rcmg/ggdb/

Intellectual Property for HS3ST4 gene
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Patent Information for HS3ST4 gene:
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HS3ST4 Gene

heparan sulfate (glucosamine) 3-O-sulfotransferase 4

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HS3ST4 Gene

heparan sulfate (glucosamine) 3-O-sulfotransferase 4

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