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Aliases for HS3ST4 Gene

Aliases for HS3ST4 Gene

  • Heparan Sulfate-Glucosamine 3-Sulfotransferase 4 2 3 5
  • Heparan Sulfate D-Glucosaminyl 3-O-Sulfotransferase 4 3 4
  • Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 4 2 3
  • Heparan Sulfate 3-O-Sulfotransferase 4 3 4
  • H3-OST-4 3 4
  • 3-OST-4 3 4
  • 3OST4 3 4
  • Heparan Sulfate 3-O-Sulfotransferase-4 3
  • EC 2.8.2.23 4
  • EC 2.8.2 63
  • 30ST4 3

External Ids for HS3ST4 Gene

Previous GeneCards Identifiers for HS3ST4 Gene

  • GC16P025131
  • GC16P025802
  • GC16P025631
  • GC16P025669
  • GC16P025610
  • GC16P023796

Summaries for HS3ST4 Gene

Entrez Gene Summary for HS3ST4 Gene

  • This gene encodes the enzyme heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4. This enzyme generates 3-O-sulfated glucosaminyl residues in heparan sulfate. Cell surface heparan sulfate is used as a receptor by herpes simplex virus type 1 (HSV-1), and expression of this gene is thought to play a role in HSV-1 pathogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for HS3ST4 Gene

HS3ST4 (Heparan Sulfate-Glucosamine 3-Sulfotransferase 4) is a Protein Coding gene. Among its related pathways are heparan sulfate biosynthesis and Glycosaminoglycan metabolism. GO annotations related to this gene include sulfotransferase activity and [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. An important paralog of this gene is NDST4.

UniProtKB/Swiss-Prot for HS3ST4 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HS3ST4 Gene

Genomics for HS3ST4 Gene

Regulatory Elements for HS3ST4 Gene

Enhancers for HS3ST4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HS3ST4 on UCSC Golden Path with GeneCards custom track

Genomic Location for HS3ST4 Gene

Chromosome:
16
Start:
25,692,026 bp from pter
End:
26,137,688 bp from pter
Size:
445,663 bases
Orientation:
Plus strand

Genomic View for HS3ST4 Gene

Genes around HS3ST4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HS3ST4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HS3ST4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HS3ST4 Gene

Proteins for HS3ST4 Gene

  • Protein details for HS3ST4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y661-HS3S4_HUMAN
    Recommended name:
    Heparan sulfate glucosamine 3-O-sulfotransferase 4
    Protein Accession:
    Q9Y661
    Secondary Accessions:
    • Q5QI42
    • Q8NDC2

    Protein attributes for HS3ST4 Gene

    Size:
    456 amino acids
    Molecular mass:
    49799 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HS3ST4 Gene

Proteomics data for HS3ST4 Gene at MOPED

Selected DME Specific Peptides for HS3ST4 Gene

Post-translational modifications for HS3ST4 Gene

  • Glycosylation at Asn 105, Asn 178, Asn 318, and Asn 389

Other Protein References for HS3ST4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for HS3ST4 (Heparan Sulfate 3-O-Sulfotransferase 4/HS3ST4)

Domains & Families for HS3ST4 Gene

Gene Families for HS3ST4 Gene

Protein Domains for HS3ST4 Gene

Suggested Antigen Peptide Sequences for HS3ST4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y661

UniProtKB/Swiss-Prot:

HS3S4_HUMAN :
  • Belongs to the sulfotransferase 1 family.
Family:
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with HS3ST4: view

Function for HS3ST4 Gene

Molecular function for HS3ST4 Gene

GENATLAS Biochemistry:
heparan sulfate D-glucosamine 3-O-sulfotransferase 4,putative regulator of heparan sulfate proteoglycan properties
UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3,5-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate.
UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity).

Enzyme Numbers (IUBMB) for HS3ST4 Gene

genes like me logo Genes that share phenotypes with HS3ST4: view

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HS3ST4 Gene

Localization for HS3ST4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HS3ST4 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HS3ST4 Gene COMPARTMENTS Subcellular localization image for HS3ST4 gene
Compartment Confidence
golgi apparatus 4
mitochondrion 2
cytosol 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HS3ST4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HS3ST4: view

Pathways & Interactions for HS3ST4 Gene

genes like me logo Genes that share pathways with HS3ST4: view

Interacting Proteins for HS3ST4 Gene

Gene Ontology (GO) - Biological Process for HS3ST4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030201 heparan sulfate proteoglycan metabolic process NAS 9988767
genes like me logo Genes that share ontologies with HS3ST4: view

No data available for SIGNOR curated interactions for HS3ST4 Gene

Drugs & Compounds for HS3ST4 Gene

(1) Drugs for HS3ST4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Iduronic acid Experimental Pharma 0

(2) Additional Compounds for HS3ST4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
1053-73-2
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
482-67-7
genes like me logo Genes that share compounds with HS3ST4: view

Transcripts for HS3ST4 Gene

mRNA/cDNA for HS3ST4 Gene

Unigene Clusters for HS3ST4 Gene

Heparan sulfate (glucosamine) 3-O-sulfotransferase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HS3ST4 Gene

No ASD Table

Relevant External Links for HS3ST4 Gene

GeneLoc Exon Structure for
HS3ST4
ECgene alternative splicing isoforms for
HS3ST4

Expression for HS3ST4 Gene

mRNA expression in normal human tissues for HS3ST4 Gene

mRNA differential expression in normal tissues according to GTEx for HS3ST4 Gene

This gene is overexpressed in Brain - Cortex (x8.3), Brain - Frontal Cortex (BA9) (x6.1), Brain - Hippocampus (x5.8), Brain - Anterior cingulate cortex (BA24) (x5.7), and Brain - Hypothalamus (x4.1).

Protein differential expression in normal tissues from HIPED for HS3ST4 Gene

This gene is overexpressed in Liver, secretome (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HS3ST4 Gene



SOURCE GeneReport for Unigene cluster for HS3ST4 Gene Hs.655275

mRNA Expression by UniProt/SwissProt for HS3ST4 Gene

Q9Y661-HS3S4_HUMAN
Tissue specificity: Brain-specific.
genes like me logo Genes that share expression patterns with HS3ST4: view

Protein tissue co-expression partners for HS3ST4 Gene

- Elite partner

Primer Products

Orthologs for HS3ST4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HS3ST4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HS3ST4 35
  • 94.74 (n)
  • 99.04 (a)
dog
(Canis familiaris)
Mammalia HS3ST4 35
  • 91.92 (n)
  • 91.22 (a)
mouse
(Mus musculus)
Mammalia Hs3st4 35
  • 86.59 (n)
  • 89.88 (a)
Hs3st4 16
Hs3st4 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HS3ST4 35
  • 99.68 (n)
  • 99.52 (a)
rat
(Rattus norvegicus)
Mammalia LOC691700 35
  • 87.92 (n)
  • 93.12 (a)
chicken
(Gallus gallus)
Aves HS3ST4 35
  • 82.52 (n)
  • 91.61 (a)
HS3ST4 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 75 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492416 35
  • 74.59 (n)
  • 82.81 (a)
zebrafish
(Danio rerio)
Actinopterygii hs3st4 35
  • 67.76 (n)
  • 70.28 (a)
hs3st4 36
  • 66 (a)
OneToOne
Species with no ortholog for HS3ST4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HS3ST4 Gene

ENSEMBL:
Gene Tree for HS3ST4 (if available)
TreeFam:
Gene Tree for HS3ST4 (if available)

Paralogs for HS3ST4 Gene

(9) SIMAP similar genes for HS3ST4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HS3ST4: view

Variants for HS3ST4 Gene

Sequence variations from dbSNP and Humsavar for HS3ST4 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs2943336 - 25,692,824(-) CGTCC(C/T)GGGCG reference, missense
rs2618 -- 26,004,526(+) AAGCA(A/G)GCACT intron-variant
rs2619 -- 26,004,471(+) AGAAA(A/T)AAAGG intron-variant
rs3922857 -- 25,965,686(+) TCCTT(C/T)TCATG intron-variant
rs3923414 -- 25,964,879(-) TAATA(C/T)ACTCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HS3ST4 Gene

Variant ID Type Subtype PubMed ID
dgv841e1 CNV Complex 17122850
esv2714126 CNV Deletion 23290073
esv2714127 CNV Deletion 23290073
esv2714128 CNV Deletion 23290073
esv989105 CNV Deletion 20482838
esv1614178 CNV Deletion 17803354
nsv9407 CNV Loss 18304495
esv2666037 CNV Deletion 23128226
nsv521162 CNV Gain 19592680
esv2714130 CNV Deletion 23290073
esv8601 CNV Gain 19470904
esv269084 CNV Insertion 20981092
dgv164n21 CNV Loss 19592680
nsv519437 CNV Loss 19592680
esv2714131 CNV Deletion 23290073
esv271094 CNV Insertion 20981092
nsv507811 CNV Insertion 20534489

Variation tolerance for HS3ST4 Gene

Residual Variation Intolerance Score: 61.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.06; 60.78% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HS3ST4 Gene

Disorders for HS3ST4 Gene

Relevant External Links for HS3ST4

Genetic Association Database (GAD)
HS3ST4
Human Genome Epidemiology (HuGE) Navigator
HS3ST4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HS3ST4

No disorders were found for HS3ST4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HS3ST4 Gene

Publications for HS3ST4 Gene

  1. Multiple isoforms of heparan sulfate D-glucosaminyl 3-O- sulfotransferase. Isolation, characterization, and expression of human cDNAs and identification of distinct genomic loci. (PMID: 9988767) Shworak N.W. … Rosenberg R.D. (J. Biol. Chem. 1999) 2 3 4 23 67
  2. Genome-wide studies of verbal declarative memory in nondemented older people: the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium. (PMID: 25648963) Debette S. … Mosley T.H. (Biol. Psychiatry 2015) 3
  3. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. (PMID: 24324551) Deng X. … Seielstad M. (PLoS ONE 2013) 3
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for HS3ST4 Gene

Sources for HS3ST4 Gene

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