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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HS3ST4 Gene

protein-coding   GIFtS: 50
GCID: GC16P025610

Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 41 2     30ST42 5
Heparan Sulfate 3-O-Sulfotransferase 42 3     Heparan Sulfate 3-O-Sulfotransferase-42
Heparan Sulfate D-Glucosaminyl 3-O-Sulfotransferase 42 3     Heparan Sulfate Glucosamine 3-O-Sulfotransferase 42
3-OST-42 3     EC 2.8.2.233
3OST42 3     EC 2.8.28
h3-OST-42 3     

External Ids:    HGNC: 52001   Entrez Gene: 99512   Ensembl: ENSG000001826017   OMIM: 6040595   UniProtKB: Q9Y6613   

Export aliases for HS3ST4 gene to outside databases

Previous GC identifers: GC16P025131 GC16P025802 GC16P025631 GC16P025669 GC16P023796


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HS3ST4 Gene:
This gene encodes the enzyme heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4. This enzyme generates
3-O-sulfated glucosaminyl residues in heparan sulfate. Cell surface heparan sulfate is used as a receptor by
herpes simplex virus type 1 (HSV-1), and expression of this gene is thought to play a role in HSV-1 pathogenesis.
(provided by RefSeq, Jul 2008)

GeneCards Summary for HS3ST4 Gene: 
HS3ST4 (heparan sulfate (glucosamine) 3-O-sulfotransferase 4) is a protein-coding gene. Diseases associated with HS3ST4 include herpes simplex, and morquio syndrome b, and among its related super-pathways are Metabolism of carbohydrates and Glycosaminoglycan biosynthesis - heparan sulfate / heparin. GO annotations related to this gene include [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. An important paralog of this gene is HS3ST2.

UniProtKB/Swiss-Prot: HS3S4_HUMAN, Q9Y661
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo
group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Unlike
3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HS3ST4 gene promoter:
         AhR   p300   C/EBPalpha   AREB6   CHOP-10   HSF2   FOXJ2 (long isoform)   HOXA5   FOXJ2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHS3ST4 promoter sequence
   Search SABiosciences Chromatin IP Primers for HS3ST4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HS3ST4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p12.1   HGNC cytogenetic band: 16p11.2

HS3ST4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HS3ST4 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P025610:  view genomic region     (about GC identifiers)

Start:
25,703,347 bp from pter      End:
26,149,009 bp from pter
Size:
445,663 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HS3S4_HUMAN, Q9Y661 (See protein sequence)
Recommended Name: Heparan sulfate glucosamine 3-O-sulfotransferase 4  
Size: 456 amino acids; 49799 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (Probable)
Secondary accessions: Q5QI42 Q8NDC2

Explore the universe of human proteins at neXtProt for HS3ST4: NX_Q9Y661

Explore proteomics data for HS3ST4 at MOPED 

4/7 DME Specific Peptides for HS3ST4 (Q9Y661) (see all 7)
 EPHFFDR  TKGFPCLKK  FYFNKTKGF  KGGTRALLE 

HS3ST4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

HS3ST4 Protein Expression
REFSEQ proteins: NP_006031.2  
ENSEMBL proteins: 
 ENSP00000330606  
Reactome Protein details: Q9Y661
Human Recombinant Protein Products for HS3ST4: 
Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for HS3ST4 (Heparan Sulfate 3-O-Sulfotransferase 4/HS3ST4)
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Novus Biologicals HS3ST4 Proteins
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Cloud-Clone Corp. Proteins for HS3ST4 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000139Golgi membrane IEA--
GO:0005576extracellular region NAS--
GO:0016021integral to membrane IEA--

HS3ST4 for ontologies           About GeneDecksing



HS3ST4 Antibody Products: 
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LSBio Antibodies in human, mouse, rat for HS3ST4 

Assay Products for HS3ST4: 
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Cloud-Clone Corp. ELISAs for HS3ST4 
Cloud-Clone Corp. CLIAs for HS3ST4


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
SULTM: Sulfotransferases, membrane-bound

2 InterPro protein domains:
 IPR000863 Sulfotransferase_dom
 IPR027417 P-loop_NTPase

Graphical View of Domain Structure for InterPro Entry Q9Y661

ProtoNet protein and cluster: Q9Y661

UniProtKB/Swiss-Prot: HS3S4_HUMAN, Q9Y661
Similarity: Belongs to the sulfotransferase 1 family


HS3ST4 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: HS3S4_HUMAN, Q9Y661
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo
group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Unlike
3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity)
Catalytic activity: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate +
[heparan sulfate]-glucosamine 3-sulfate

     Genatlas biochemistry entry for HS3ST4:
heparan sulfate D-glucosamine 3-O-sulfotransferase 4,putative regulator of heparan sulfate proteoglycan properties

     Enzyme Numbers (IUBMB): EC 2.8.2.231 EC 2.8.22

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008146sulfotransferase activity ----
GO:0008467[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity NAS9988767
     
HS3ST4 for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for HS3ST4 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HS3ST4

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HS3ST4 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HS3ST4 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HS3ST4
8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate HS3ST4 (see all 38):
hsa-miR-579 hsa-miR-100* hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-4254 hsa-miR-485-3p hsa-miR-29b-1*
SwitchGear 3'UTR luciferase reporter plasmidHS3ST4 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for HS3ST4
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HS3ST4

Gene Editing
Products:
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Sirion Biotech Customized adenovirus for overexpression of HS3ST4

Clone
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OriGene clones in human, mouse for HS3ST4 (see all 6)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HS3ST4
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                     Customized lentivirus expression plasmids for stable overexpression of HS3ST4 

Cell Line
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Search LifeMap BioReagents cell lines for HS3ST4
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HS3ST4


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for HS3ST4 About   (see all 7)                                                                                              See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1MPS IIIC - Sanfilippo syndrome C
MPS IIIC - Sanfilippo syndrome C0.48
Mucopolysaccharidoses0.48
MPS IV - Morquio syndrome A0.48
MPS IIID - Sanfilippo syndrome D0.48
MPS IV - Morquio syndrome B0.48
MPS I - Hurler syndrome0.48
MPS VI - Maroteaux-Lamy syndrome0.48
MPS IX - Natowicz syndrome0.48
2heparan sulfate biosynthesis
heparan sulfate biosynthesis0.79
heparan sulfate biosynthesis (late stages)0.77
3Heparan sulfate/heparin (HS-GAG) metabolism
Heparan sulfate/heparin (HS-GAG) metabolism0.56
HS-GAG biosynthesis0.56
4Biological oxidations
metapathway biotransformation0.41
5Metabolism
Metabolism0.40

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 R&D Systems Pathway for HS3ST4
    Articular Cartilage Extracellular Matrix


3 BioSystems Pathways for HS3ST4
    heparan sulfate biosynthesis (late stages)
metapathway biotransformation
heparan sulfate biosynthesis

5/18        Reactome Pathways for HS3ST4 (see all 18)
    MPS VI - Maroteaux-Lamy syndrome
Metabolism
Disease
HS-GAG biosynthesis
MPS II - Hunter syndrome



HS3ST4 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HS3ST4

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0030201heparan sulfate proteoglycan metabolic process NAS9988767

HS3ST4 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HS3ST4 (HS3S4)

1 HMDB Compound for HS3ST4    About this table
CompoundSynonyms CAS #PubMed Ids
Iduronic acidL-Iduronate (see all 3)3402-98-0--

Search CenterWatch for drugs/clinical trials and news about HS3ST4 / HS3S4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HS3ST4 gene: 
NM_006040.2  

Unigene Cluster for HS3ST4:

Heparan sulfate (glucosamine) 3-O-sulfotransferase 4
Hs.655275  [show with all ESTs]
Unigene Representative Sequence: NM_006040
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000331351(uc002dof.3) ENST00000475436
miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HS3ST4
8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate HS3ST4 (see all 38):
hsa-miR-579 hsa-miR-100* hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-4254 hsa-miR-485-3p hsa-miR-29b-1*
SwitchGear 3'UTR luciferase reporter plasmidHS3ST4 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for HS3ST4
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HS3ST4
Clone
Products:
     
OriGene clones in human, mouse for HS3ST4 (see all 6)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: HS3ST4 (NM_006040)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HS3ST4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HS3ST4
Sirion Biotech Customized lentivirus for stable overexpression of HS3ST4 
                     Customized lentivirus expression plasmids for stable overexpression of HS3ST4 
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for HS3ST4
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HS3ST4
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HS3ST4
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HS3ST4

Additional mRNA sequence: 

AF105378.2 AL834283.1 EF063601.1 EF063602.1 EF063603.1 EF063604.1 EF063605.1 EF063606.1 
EF063607.1 EF063608.1 

1 DOTS entry:

DT.111189 

24/42 AceView cDNA sequences (see all 42):

AA776654 CB154928 BU741565 AA639141 F13088 BM727888 BE328142 AW136756 
F10682 AA317840 T33472 AL834283 AI468731 AA973808 BF433598 BI752684 
AW205326 BX478504 BE670927 AW204561 AA724994 NM_006040 AW204697 AI825533 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HS3ST4 expression in normal human tissues (normalized intensities)      HS3ST4 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
HS3ST4 Expression
About this image


HS3ST4 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/6 selected tissues (see all 6) fully expand
 
 Brain (Nervous System)    fully expand to see all 7 entries
         Thalamus
         brain/midbrain/lateral wall   
 
 Neural Tube (Nervous System)    fully expand to see all 6 entries
         Metencephalon
         brain/midbrain/lateral wall   
 
 Hair (Integumentary System)
         mouse/organ system/integumental system   
 
 Tooth
         mouse/organ system/integumental system   
 
 Bone (Muscoskeletal System)
         sensory organ/ear/inner ear   

See HS3ST4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HS3ST4

SOURCE GeneReport for Unigene cluster: Hs.655275

UniProtKB/Swiss-Prot: HS3S4_HUMAN, Q9Y661
Tissue specificity: Brain-specific

    SABiosciences Custom PCR Arrays for HS3ST4
Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HS3ST4
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HS3ST4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for HS3ST4 gene from 5/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Hs3st41 , 5 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 less1, 5 86.76(n)1
90.18(a)1
  7 (67.56 cM)5
6287791  NM_001252072.11  NP_001239001.11 
 1239828695 
chicken
(Gallus gallus)
Aves HS3ST41 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 less 82.52(n)
91.61(a)
  427674  XM_425248.3  XP_425248.3 
zebrafish
(Danio rerio)
Actinopterygii hs3st41 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 less 68.82(n)
73.39(a)
  563570  NM_001080589.1  NP_001074058.1 
fruit fly
(Drosophila melanogaster)
Insecta Hs3st-B6
Heparan sulfate 3-O sulfotransferase-B
48(a)
1 → many
X(19143021-19146078)
worm
(Caenorhabditis elegans)
Secernentea hst-3.26
Protein HST-3.2
46(a)
1 → many
X(2918805-2923984)


ENSEMBL Gene Tree for HS3ST4 (if available)
TreeFam Gene Tree for HS3ST4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for HS3ST4 gene
HS3ST22  ZSWIM8-AS12  HS3ST12  HS3ST3B12  HS3ST62  HS3ST52  HS3ST3A12  NDST12  
NDST42  NDST32  
9 SIMAP similar genes for HS3ST4 using alignment to 2 protein entries:     HS3S4_HUMAN (see all proteins):
HS3ST3A1    HS3ST2    HS3ST6    HS3ST3B1    HS3ST1    HS3ST5
NDST1    NDST4    NDST2

HS3ST4 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/9869 SNPs in HS3ST4 are shown (see all 9869)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1828657831,2
--25701571(+) AAACTA/GGGCAT 1 -- us2k10--------
rs802149871,2
C,F--25701907(+) GACTCC/TGCATT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
rs1511544881,2
--25702144(+) TTTTCC/TTATTA 1 -- us2k10--------
rs1872533091,2
--25702170(+) CCAGAA/GATGCC 1 -- us2k10--------
rs799163641,2
C,F--25702493(+) AAAATA/TCACTT 1 -- us2k13Minor allele frequency- T:0.04CSA WA 122
rs1390458141,2
--25702614(+) AACTCC/TGTTAG 1 -- us2k10--------
rs740148211,2
C,F--25702813(+) GGGCGG/CGGGGC 1 -- us2k13Minor allele frequency- C:0.07WA NA 240
rs799999761,2
C--25702896(+) GAGGAC/TATCCC 1 -- us2k10--------
rs13993381,2
C,F,H--25702902(-) TCGCCC/TGGGAT 1 -- us2k118Minor allele frequency- T:0.21MN NS EA NA WA 2516
rs711589621,2
C--25703137(+) GGGGGG/-CTGGG 1 -- us2k12Minor allele frequency- -:0.25NA CSA 4

HapMap Linkage Disequilibrium report for HS3ST4 (25703347 - 25953347 bp, first 250kb of HS3ST4)

Structural Variations
     Database of Genomic Variants (DGV) 10/17 variations for HS3ST4 (see all 17):    About this table     
Variant IDTypeSubtypePubMed ID
esv2714130CNV Deletion23290073
esv989105CNV Deletion20482838
esv2714128CNV Deletion23290073
esv2714127CNV Deletion23290073
esv2666037CNV Deletion23128226
esv2714131CNV Deletion23290073
esv1614178CNV Deletion17803354
esv2714126CNV Deletion23290073
nsv507811CNV Insertion20534489
esv269084CNV Insertion20981092

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing HS3ST4
DNA2.0 Custom Variant and Variant Library Synthesis for HS3ST4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 604059    OMIM disorders: --

3 diseases for HS3ST4:    About MalaCards
herpes simplex    morquio syndrome b    neuronitis


HS3ST4 for disorders           About GeneDecksing

Genetic Association Database (GAD): HS3ST4
Human Genome Epidemiology (HuGE) Navigator: HS3ST4 (2 documents)

Export disorders for HS3ST4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for HS3ST4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with HS3ST4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Multiple isoforms of heparan sulfate D-glucosaminyl 3-O- sulfotransferase. Isolation, characterization, and expression of human cDNAs and identification of distinct genomic loci. (PubMed id 9988767)1, 2, 3, 9 Shworak N.W.... Rosenberg R.D. (1999)
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
  4. Tetrasulfated disaccharide unit in heparan sulfate: enzymatic formation and tissue distribution. (PubMed id 18757372)1 Mochizuki H....Kimata K. (2008)
  5. The principal neuronal gD-type 3-O-sulfotransferases and their products in central and peripheral nervous system tissues. (PubMed id 17482450)1 Lawrence R....Shworak N.W. (2007)
  6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
  7. A role for 3-O-sulfotransferase isoform-4 in assisting HSV-1 entry and spread. (PubMed id 16259945)1 Tiwari V....Shukla D. (2005)
  8. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
  9. Characterization of a heparan sulfate octasaccharide that binds to herpes simplex virus type 1 glycoprotein D. (PubMed id 12080045)1 Liu J....Sasisekharan R. (2002)
  10. A second-generation genomewide screen for asthma-susceptibility alleles in a founder population. (PubMed id 11022011)4 Ober C....Cox N.J. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 9951 HGNC: 5200 AceView: HS3ST4 Ensembl:ENSG00000182601 euGenes: HUgn9951
ECgene: HS3ST4 H-InvDB: HS3ST4

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for HS3ST4 Pharmacogenomics, SNPs, Pathways
GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for HS3ST4 gene:
Search GeneIP for patents involving HS3ST4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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