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Aliases for HS3ST3B1 Gene

Aliases for HS3ST3B1 Gene

  • Heparan Sulfate-Glucosamine 3-Sulfotransferase 3B1 2 3 5
  • Heparan Sulfate D-Glucosaminyl 3-O-Sulfotransferase 3B1 3 4
  • Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 3B1 2 3
  • Heparan Sulfate 3-O-Sulfotransferase 3B1 3 4
  • H3-OST-3B 3 4
  • 3-OST-3B 3 4
  • 3OST3B1 3 4
  • Heparan Sulfate Glucosamine 3-O-Sulfotransferase 3B1 3
  • EC 2.8.2.30 4
  • EC 2.8.2 61
  • HS3ST3B 4

External Ids for HS3ST3B1 Gene

Previous GeneCards Identifiers for HS3ST3B1 Gene

  • GC17P014570
  • GC17P015319
  • GC17P014147
  • GC17P014404
  • GC17P014145
  • GC17P014098

Summaries for HS3ST3B1 Gene

Entrez Gene Summary for HS3ST3B1 Gene

  • The protein encoded by this gene is a type II integral membrane protein that belongs to the 3-O-sulfotransferases family. These proteins catalyze the addition of sulfate groups at the 3-OH position of glucosamine in heparan sulfate. The substrate specificity of individual members of the family is based on prior modification of the heparan sulfate chain, thus allowing different members of the family to generate binding sites for different proteins on the same heparan sulfate chain. Following treatment with a histone deacetylase inhibitor, expression of this gene is activated in a pancreatic cell line. The increased expression results in promotion of the epithelial-mesenchymal transition. In addition, the modification catalyzed by this protein allows herpes simplex virus membrane fusion and penetration. A very closely related homolog with an almost identical sulfotransferase domain maps less than 1 Mb away. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

GeneCards Summary for HS3ST3B1 Gene

HS3ST3B1 (Heparan Sulfate-Glucosamine 3-Sulfotransferase 3B1) is a Protein Coding gene. Diseases associated with HS3ST3B1 include Herpes Simplex. Among its related pathways are Cytochrome P450 - arranged by substrate type and Metabolism. GO annotations related to this gene include sulfotransferase activity and [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity. An important paralog of this gene is HS3ST3A1.

UniProtKB/Swiss-Prot for HS3ST3B1 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.

Gene Wiki entry for HS3ST3B1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HS3ST3B1 Gene

Genomics for HS3ST3B1 Gene

Regulatory Elements for HS3ST3B1 Gene

Enhancers for HS3ST3B1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F014299 1.4 FANTOM5 Ensembl ENCODE 16.6 +4.0 3990 12.0 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 HS3ST3B1 ENSG00000262786 ENSG00000266744 LINC02096 RPL23AP76 CDRT7 LOC101928475 LINC02093 CDRT8 MGC12916
GH17F014351 1.3 FANTOM5 Ensembl ENCODE 9.9 +52.0 51969 3.6 RFX1 CEBPB NR2F2 HS3ST3B1 MGC12916 GC17P014349 GC17M014360
GH17F014359 1.4 FANTOM5 Ensembl ENCODE 6.9 +59.1 59051 2.2 GATAD2A CTCF MTA2 CEBPB TBX21 RAD21 RELA SMARCA4 FOXK2 POLR2A HS3ST3B1 GC17M014360 GC17P014349
GH17F014208 0.2 ENCODE 5 -91.6 -91616 1.8 HDAC1 ARID4B RAD21 YY1 CREM THAP11 CEBPB ZEB2 ZNF589 ATF4 CDRT15 COX10 CDRT15P1 ENSG00000231595 HS3ST3B1 ENSG00000252305
GH17F014790 1 FANTOM5 Ensembl 4.8 +489.8 489795 0.7 SMARCA4 POLR2A HS3ST3B1 GC17M014781 LOC105371545
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HS3ST3B1 on UCSC Golden Path with GeneCards custom track

Promoters for HS3ST3B1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001341313 951 6000 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for HS3ST3B1 Gene

Chromosome:
17
Start:
14,301,050 bp from pter
End:
14,349,406 bp from pter
Size:
48,357 bases
Orientation:
Plus strand

Genomic View for HS3ST3B1 Gene

Genes around HS3ST3B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HS3ST3B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HS3ST3B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HS3ST3B1 Gene

Proteins for HS3ST3B1 Gene

  • Protein details for HS3ST3B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y662-HS3SB_HUMAN
    Recommended name:
    Heparan sulfate glucosamine 3-O-sulfotransferase 3B1
    Protein Accession:
    Q9Y662
    Secondary Accessions:
    • B3KN58
    • D3DTS6

    Protein attributes for HS3ST3B1 Gene

    Size:
    390 amino acids
    Molecular mass:
    43324 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HS3ST3B1 Gene

Selected DME Specific Peptides for HS3ST3B1 Gene

Post-translational modifications for HS3ST3B1 Gene

  • Glycosylation at Thr 79, Asn 258, and Asn 329
  • Modification sites at PhosphoSitePlus

Other Protein References for HS3ST3B1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for HS3ST3B1 (Heparan Sulfate Glucosamine 3-O-Sulfotransferase 3)

Domains & Families for HS3ST3B1 Gene

Gene Families for HS3ST3B1 Gene

Protein Domains for HS3ST3B1 Gene

Suggested Antigen Peptide Sequences for HS3ST3B1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y662

UniProtKB/Swiss-Prot:

HS3SB_HUMAN :
  • Belongs to the sulfotransferase 1 family.
Family:
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with HS3ST3B1: view

Function for HS3ST3B1 Gene

Molecular function for HS3ST3B1 Gene

GENATLAS Biochemistry:
heparan sulfate D-glucosamine 3-O-sulfotransferase 3B1,widely expressed with multiple transcripts active according to the saccharide structures around the GLN residue,putative regulator of heparan sulfate proteoglycan properties
UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3,5-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate.
UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.

Enzyme Numbers (IUBMB) for HS3ST3B1 Gene

Gene Ontology (GO) - Molecular Function for HS3ST3B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008146 sulfotransferase activity IEA --
GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity TAS --
GO:0016740 transferase activity IEA --
GO:0033872 [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity IEA --
genes like me logo Genes that share ontologies with HS3ST3B1: view
genes like me logo Genes that share phenotypes with HS3ST3B1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HS3ST3B1 Gene

Localization for HS3ST3B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HS3ST3B1 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HS3ST3B1 Gene COMPARTMENTS Subcellular localization image for HS3ST3B1 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 5
cytosol 1
extracellular 1
lysosome 1
mitochondrion 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for HS3ST3B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0005887 integral component of plasma membrane TAS 9988767
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HS3ST3B1: view

Pathways & Interactions for HS3ST3B1 Gene

genes like me logo Genes that share pathways with HS3ST3B1: view

Interacting Proteins for HS3ST3B1 Gene

Gene Ontology (GO) - Biological Process for HS3ST3B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006024 glycosaminoglycan biosynthetic process TAS --
GO:0015012 heparan sulfate proteoglycan biosynthetic process TAS 9988768
GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification TAS 9988767
genes like me logo Genes that share ontologies with HS3ST3B1: view

No data available for SIGNOR curated interactions for HS3ST3B1 Gene

Drugs & Compounds for HS3ST3B1 Gene

(3) Additional Compounds for HS3ST3B1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
1053-73-2
Iduronic acid
  • Iduronate
  • L-Iduronate
  • L-Iduronic acid
3402-98-0
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
482-67-7
genes like me logo Genes that share compounds with HS3ST3B1: view

Transcripts for HS3ST3B1 Gene

mRNA/cDNA for HS3ST3B1 Gene

Unigene Clusters for HS3ST3B1 Gene

Heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HS3ST3B1 Gene

No ASD Table

Relevant External Links for HS3ST3B1 Gene

GeneLoc Exon Structure for
HS3ST3B1
ECgene alternative splicing isoforms for
HS3ST3B1

Expression for HS3ST3B1 Gene

mRNA expression in normal human tissues for HS3ST3B1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HS3ST3B1 Gene

This gene is overexpressed in Liver (x12.1) and Whole Blood (x5.4).

Protein differential expression in normal tissues from HIPED for HS3ST3B1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HS3ST3B1 Gene



Protein tissue co-expression partners for HS3ST3B1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HS3ST3B1 Gene:

HS3ST3B1

SOURCE GeneReport for Unigene cluster for HS3ST3B1 Gene:

Hs.48384

mRNA Expression by UniProt/SwissProt for HS3ST3B1 Gene:

Q9Y662-HS3SB_HUMAN
Tissue specificity: Ubiquitous. Most abundant in liver and placenta, followed by heart and kidney.
genes like me logo Genes that share expression patterns with HS3ST3B1: view

Primer Products

Orthologs for HS3ST3B1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HS3ST3B1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HS3ST3B1 34 35
  • 99.57 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 94 (a)
ManyToMany
HS3ST3B1 34
  • 92.56 (n)
-- 35
  • 68 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia HS3ST3B1 34 35
  • 88.83 (n)
-- 35
  • 65 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Hs3st3b1 34 16 35
  • 87.69 (n)
Hs3st3a1 35
  • 68 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Hs3st3b1 34
  • 87.69 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 63 (a)
OneToMany
chicken
(Gallus gallus)
Aves HS3ST3A1 34
  • 88.93 (n)
-- 35
  • 83 (a)
ManyToMany
-- 35
  • 82 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 73 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.14458 34
zebrafish
(Danio rerio)
Actinopterygii hs3st3b1b 35
  • 66 (a)
ManyToMany
si:ch211-216b21.2 35
  • 62 (a)
ManyToMany
hs3st3b1a 35
  • 61 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000422 34
  • 72.03 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7890 36
  • 66 (a)
Hs3st-B 34
  • 60.98 (n)
worm
(Caenorhabditis elegans)
Secernentea hst-3 36
  • 41 (a)
Species where no ortholog for HS3ST3B1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HS3ST3B1 Gene

ENSEMBL:
Gene Tree for HS3ST3B1 (if available)
TreeFam:
Gene Tree for HS3ST3B1 (if available)

Paralogs for HS3ST3B1 Gene

(6) SIMAP similar genes for HS3ST3B1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HS3ST3B1: view

Variants for HS3ST3B1 Gene

Sequence variations from dbSNP and Humsavar for HS3ST3B1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1005321 -- 14,318,184(-) CCGAG(C/T)GGGGA intron-variant
rs1005322 -- 14,318,066(-) GATTC(C/T)GCAGG intron-variant
rs1006105 -- 14,316,719(-) GGGGA(A/G)AATGC intron-variant
rs1015663 -- 14,334,770(-) agaga(C/T)gattc intron-variant
rs1052686 -- 14,304,113(+) GCTGC(C/G)GACTT intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for HS3ST3B1 Gene

Variant ID Type Subtype PubMed ID
esv2664356 CNV deletion 23128226
esv3640020 CNV loss 21293372
esv3640021 CNV gain 21293372
esv3640025 CNV loss 21293372
esv3640026 CNV gain 21293372
esv3640027 CNV loss 21293372
esv3640028 CNV loss 21293372
esv3640029 CNV gain 21293372
nsv477356 CNV novel sequence insertion 20440878
nsv574377 CNV gain 21841781

Variation tolerance for HS3ST3B1 Gene

Residual Variation Intolerance Score: 75.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.40; 54.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HS3ST3B1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HS3ST3B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HS3ST3B1 Gene

Disorders for HS3ST3B1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HS3ST3B1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
herpes simplex
  • herpesvirus hominis disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HS3ST3B1

Genetic Association Database (GAD)
HS3ST3B1
Human Genome Epidemiology (HuGE) Navigator
HS3ST3B1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HS3ST3B1
genes like me logo Genes that share disorders with HS3ST3B1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HS3ST3B1 Gene

Publications for HS3ST3B1 Gene

  1. Multiple isoforms of heparan sulfate D-glucosaminyl 3-O- sulfotransferase. Isolation, characterization, and expression of human cDNAs and identification of distinct genomic loci. (PMID: 9988767) Shworak N.W. … Rosenberg R.D. (J. Biol. Chem. 1999) 2 3 4 64
  2. Analysis of copy number variation in 8,842 Korean individuals reveals 39 genes associated with hepatic biomarkers AST and ALT. (PMID: 20797317) Kim H.Y. … Kim H. (BMB Rep 2010) 3 46 64
  3. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PMID: 18464913) Melzer D. … Ferrucci L. (PLoS Genet. 2008) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for HS3ST3B1 Gene

Sources for HS3ST3B1 Gene

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