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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HS3ST3B1 Gene

protein-coding   GIFtS: 55
GCID: GC17P014145

Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 3B1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 3B11 2     30ST3B12 5
Heparan Sulfate 3-O-Sulfotransferase 3B12 3     Heparan Sulfate Glucosamine 3-O-Sulfotransferase 3B12
Heparan Sulfate D-Glucosaminyl 3-O-Sulfotransferase 3B12 3     EC 2.8.2.303
3-OST-3B2 3     HS3ST3B3
3OST3B12 3     EC 2.8.28
h3-OST-3B2 3     

External Ids:    HGNC: 51981   Entrez Gene: 99532   Ensembl: ENSG000001254307   OMIM: 6040585   UniProtKB: Q9Y6623   

Export aliases for HS3ST3B1 gene to outside databases

Previous GC identifers: GC17P014570 GC17P015319 GC17P014147 GC17P014404 GC17P014098


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HS3ST3B1 Gene:
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine
structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the
heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan
sulfate glucosaminyl 3-O-sulfotransferase activity. The sulfotransferase domain of this enzyme is highly similar
to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1, and these two enzymes sulfate an
identical disaccharide. This gene is widely expressed, with the most abundant expression in liver and placenta.
(provided by RefSeq, Jul 2008)

GeneCards Summary for HS3ST3B1 Gene: 
HS3ST3B1 (heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1) is a protein-coding gene. Diseases associated with HS3ST3B1 include papillon-lefevre disease, and morquio syndrome b, and among its related super-pathways are Glycosaminoglycan biosynthesis - heparan sulfate / heparin and Metabolism of carbohydrates. GO annotations related to this gene include [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity and [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity. An important paralog of this gene is HS3ST2.

UniProtKB/Swiss-Prot: HS3SB_HUMAN, Q9Y662
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo
group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes
the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation
generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1)
and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant
heparan sulfate

Gene Wiki entry for HS3ST3B1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HS3ST3B1 gene promoter:
         USF1   USF2   USF-1:USF-2   Max   CREB   POU2F1   POU2F1a   Zic1   USF-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHS3ST3B1 promoter sequence
   Search SABiosciences Chromatin IP Primers for HS3ST3B1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HS3ST3B1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p12   Ensembl cytogenetic band:  17p12   HGNC cytogenetic band: 17p12

HS3ST3B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HS3ST3B1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P014145:  view genomic region     (about GC identifiers)

Start:
14,204,400 bp from pter      End:
14,252,721 bp from pter
Size:
48,322 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HS3SB_HUMAN, Q9Y662 (See protein sequence)
Recommended Name: Heparan sulfate glucosamine 3-O-sulfotransferase 3B1  
Size: 390 amino acids; 43324 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (Probable)
Secondary accessions: B3KN58 D3DTS6

Explore the universe of human proteins at neXtProt for HS3ST3B1: NX_Q9Y662

Explore proteomics data for HS3ST3B1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y662

  • 4/6 DME Specific Peptides for HS3ST3B1 (Q9Y662) (see all 6)
     EPHFFDR  LREFYRP  TKGFPCLKK  FYFNKTKGF 

    HS3ST3B1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HS3ST3B1 Protein Expression
    REFSEQ proteins: NP_006032.1  
    ENSEMBL proteins: 
     ENSP00000436078   ENSP00000354213  
    Reactome Protein details: Q9Y662
    Human Recombinant Protein Products for HS3ST3B1: 
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005887integral to plasma membrane TAS9988767

    HS3ST3B1 for ontologies           About GeneDecksing



    HS3ST3B1 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SULTM: Sulfotransferases, membrane-bound

    2 InterPro protein domains:
     IPR000863 Sulfotransferase_dom
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q9Y662

    ProtoNet protein and cluster: Q9Y662

    UniProtKB/Swiss-Prot: HS3SB_HUMAN, Q9Y662
    Similarity: Belongs to the sulfotransferase 1 family


    HS3ST3B1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HS3SB_HUMAN, Q9Y662
    Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo
    group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes
    the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation
    generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1)
    and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant
    heparan sulfate
    Catalytic activity: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate +
    [heparan sulfate]-glucosamine 3-sulfate

         Genatlas biochemistry entry for HS3ST3B1:
    heparan sulfate D-glucosamine 3-O-sulfotransferase 3B1,widely expressed with multiple transcripts active according
    to the saccharide structures around the GLN residue,putative regulator of heparan sulfate proteoglycan properties

         Enzyme Numbers (IUBMB): EC 2.8.22 EC 2.8.2.301

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008146sulfotransferase activity ----
    GO:0008467[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity TAS9988767
    GO:0033872[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity IEA--
         
    HS3ST3B1 for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidHS3ST3B1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HS3ST3B1 About   (see all 6)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1heparan sulfate biosynthesis
    heparan sulfate biosynthesis0.79
    heparan sulfate biosynthesis (late stages)0.77
    Glycosaminoglycan biosynthesis - heparan sulfate / heparin0.79
    2MPS IIIC - Sanfilippo syndrome C
    MPS IIIC - Sanfilippo syndrome C0.48
    Mucopolysaccharidoses0.48
    MPS IV - Morquio syndrome A0.48
    MPS IIID - Sanfilippo syndrome D0.48
    MPS IV - Morquio syndrome B0.48
    MPS I - Hurler syndrome0.48
    MPS VI - Maroteaux-Lamy syndrome0.48
    MPS IX - Natowicz syndrome0.48
    3Heparan sulfate/heparin (HS-GAG) metabolism
    Heparan sulfate/heparin (HS-GAG) metabolism0.56
    HS-GAG biosynthesis0.56
    4Biological oxidations
    metapathway biotransformation0.41
    5Metabolism
    Metabolism0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for HS3ST3B1
        heparan sulfate biosynthesis (late stages)
    metapathway biotransformation
    heparan sulfate biosynthesis

    5/18        Reactome Pathways for HS3ST3B1 (see all 18)
        MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Disease
    HS-GAG biosynthesis
    MPS II - Hunter syndrome


    1         Kegg Pathway  (Kegg details for HS3ST3B1):
        Glycosaminoglycan biosynthesis - heparan sulfate / heparin


    HS3ST3B1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HS3ST3B1

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006024glycosaminoglycan biosynthetic process TAS--
    GO:0015012heparan sulfate proteoglycan biosynthetic process TAS9988768
    GO:0015015heparan sulfate proteoglycan biosynthetic process, enzymatic modification TAS9988767
    GO:0030203glycosaminoglycan metabolic process TAS--

    HS3ST3B1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HS3ST3B1 (HS3SB)

    3 HMDB Compounds for HS3ST3B1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine 3',5'-diphosphate3,5-Diphosphoadenosine (see all 10)1053-73-2--
    Iduronic acidL-Iduronate (see all 3)3402-98-0--
    Phosphoadenosine phosphosulfate3'-Phospho-5'-adenylyl sulfate (see all 9)482-67-7--

    Search CenterWatch for drugs/clinical trials and news about HS3ST3B1 / HS3SB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HS3ST3B1 gene: 
    NM_006041.1  

    Unigene Cluster for HS3ST3B1:

    Heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
    Hs.48384  [show with all ESTs]
    Unigene Representative Sequence: BC063301
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000466596 ENST00000360954(uc002goh.1)
    miRNA
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    Additional mRNA sequence: 

    AF105377.1 AK023723.1 BC063301.1 BC069664.1 BC069725.1 

    2 DOTS entries:

    DT.95233849  DT.97833448 

    24/76 AceView cDNA sequences (see all 76):

    BQ027236 BX117031 AA700133 BC063301 AA777311 AA343703 CD723853 NM_006041 
    BQ004361 AF105377 AK023723 AA701233 AI184001 AW628705 H95395 BM720699 
    BM693548 BM968044 BM921406 AV719150 H59780 AI042497 AA457270 AA316808 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HS3ST3B1 expression in normal human tissues (normalized intensities)      HS3ST3B1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTCTTTGC
    HS3ST3B1 Expression
    About this image


    HS3ST3B1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
             brain/midbrain   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Chondrocytes Zeugopod Epiphyseal End
             Membranous Facial Bones
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Metanephros
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   

    See HS3ST3B1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HS3ST3B1

    SOURCE GeneReport for Unigene cluster: Hs.48384

    UniProtKB/Swiss-Prot: HS3SB_HUMAN, Q9Y662
    Tissue specificity: Ubiquitous. Most abundant in liver and placenta, followed by heart and kidney

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HS3ST3B1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HS3ST3B1 gene from 7/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hs3st3b11 , 5 heparan sulfate (glucosamine) 3-O-sulfotransferase more1, 5 87.69(n)1
    88.46(a)1
      11 (39.47 cM)5
    547101  NM_018805.21  NP_061275.21 
     638857925 
    chicken
    (Gallus gallus)
    Aves LOC7694211 heparan sulfate glucosamine 3-O-sulfotransferase 3B1-like 84.98(n)
    85.3(a)
      769421  XM_003642322.1  XP_003642370.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    67(a)
    1 → many
    2(106895052-106935514)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.144582 Xenopus laevis transcribed sequence with moderate similarity more 77.44(n)    BJ087244.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003293391 heparan sulfate glucosamine 3-O-sulfotransferase 3A1-like 79.41(n)
    87.64(a)
      100329339  XM_002664008.2  XP_002664054.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG78903
    Hs3st-B1
    heparin-glucosamine
    3-O-sulfotransferase3
    Heparan sulfate 3-O sulfotransferase-B1
    66(a)3
    69.14(n)1
    66.41(a)1
      329181  NM_133142.11  NP_573370.11 
    worm
    (Caenorhabditis elegans)
    Secernentea hst-33 heparan sulfate sulfotransferase 41(a)   II(6167677-6169230)   --


    ENSEMBL Gene Tree for HS3ST3B1 (if available)
    TreeFam Gene Tree for HS3ST3B1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HS3ST3B1 gene
    HS3ST22  ZSWIM8-AS12  HS3ST12  HS3ST42  HS3ST62  HS3ST52  HS3ST3A12  NDST12  
    NDST32  NDST42  
    6 SIMAP similar genes for HS3ST3B1 using alignment to 1 protein entry:     HS3SB_HUMAN:
    HS3ST3A1    HS3ST6    HS3ST4    HS3ST2    HS3ST5    HS3ST1

    HS3ST3B1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1041 SNPs in HS3ST3B1 are shown (see all 1041)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1142478921,2
    C,F--14096289(+) CTCTGT/CCTAAT 1 -- us2k11Minor allele frequency- C:0.09WA 118
    rs1151534141,2
    C,F--14096310(+) CTCAAC/TAGTTT 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1821882501,2
    --14096331(+) CGTCTC/TGGGCT 1 -- us2k10--------
    rs1865090081,2
    --14096373(+) CAGCCC/GGGGCG 1 -- us2k10--------
    rs1156674981,2
    F--14096431(+) TTACCG/TCTGCT 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1913587531,2
    --14096518(+) CCAGGC/GTGGGG 1 -- us2k10--------
    rs37603091,2
    C,F--14096603(-) ACCACT/GCTGTC 1 -- us2k17Minor allele frequency- G:0.25NA WA CSA EA 365
    rs37603081,2
    C,F--14096729(-) CAGCGC/AGACCC 1 -- us2k16Minor allele frequency- A:0.22NA WA CSA EA 363
    rs1478328641,2
    --14096760(+) GTTCTA/GTCCCC 1 -- us2k10--------
    rs1835531351,2
    --14096776(+) CGCTTA/GCAGCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HS3ST3B1 (14204400 - 14252721 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HS3ST3B1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2664356CNV Deletion23128226

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604058    OMIM disorders: --

    7 diseases for HS3ST3B1:    About MalaCards
    papillon-lefevre disease    morquio syndrome b    scoliosis    herpes simplex
    pancreatic cancer    pancreatitis    hepatitis

    1 disease from the University of Copenhagen DISEASES database for HS3ST3B1:
    Papillon-Lefevre disease

    HS3ST3B1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): HS3ST3B1
    Human Genome Epidemiology (HuGE) Navigator: HS3ST3B1 (2 documents)

    Export disorders for HS3ST3B1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HS3ST3B1 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with HS3ST3B1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Multiple isoforms of heparan sulfate D-glucosaminyl 3-O- sulfotransferase. Isolation, characterization, and expression of human cDNAs and identification of distinct genomic loci. (PubMed id 9988767)1, 2, 3 Shworak N.W.... Rosenberg R.D. (1999)
    2. Analysis of copy number variation in 8,842 Korean ind ividuals reveals 39 genes associated with hepatic biomarkers AST and ALT. (PubMed id 20797317)1, 4 Kim H.Y....Kim H. (2010)
    3. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PubMed id 18464913)1, 4 Melzer D....Ferrucci L. (2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities. (PubMed id 9988768)1, 2 Liu J.... Rosenberg R.D. (1999)
    7. A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry. (PubMed id 10520990)1, 2 Shukla D.... Spear P.G. (1999)
    8. Genome-wide association analyses identify multiple loc i associated with central corneal thickness and keratoconus. (PubMed id 23291589)1 Lu Y....Wong T.Y. (2013)
    9. Genetic variations in genes involved in heparan sulpha te biosynthesis are associated with Plasmodium falciparum parasitaemia: a famili al study in Burkina Faso. (PubMed id 22475533)1 Atkinson A....Rihet P. (2012)
    10. Heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3 B1, a novel epithelial-mesenchymal transition inducer in pancreatic cancer. (PubMed id 21709440)1 Song K....Li P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9953 HGNC: 5198 AceView: HS3ST3B1 Ensembl:ENSG00000125430 euGenes: HUgn9953
    ECgene: HS3ST3B1 Kegg: 9953 H-InvDB: HS3ST3B1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HS3ST3B1 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HS3ST3B1 gene:
    Search GeneIP for patents involving HS3ST3B1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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