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Aliases for HS3ST3B1 Gene

Aliases for HS3ST3B1 Gene

  • Heparan Sulfate-Glucosamine 3-Sulfotransferase 3B1 2 3 5
  • Heparan Sulfate D-Glucosaminyl 3-O-Sulfotransferase 3B1 3 4
  • Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 3B1 2 3
  • Heparan Sulfate 3-O-Sulfotransferase 3B1 3 4
  • H3-OST-3B 3 4
  • 3-OST-3B 3 4
  • 3OST3B1 3 4
  • EC 2.8.2.30 4
  • EC 2.8.2 63
  • HS3ST3B 4

External Ids for HS3ST3B1 Gene

Previous GeneCards Identifiers for HS3ST3B1 Gene

  • GC17P014570
  • GC17P015319
  • GC17P014147
  • GC17P014404
  • GC17P014145
  • GC17P014098

Summaries for HS3ST3B1 Gene

Entrez Gene Summary for HS3ST3B1 Gene

  • The protein encoded by this gene is a type II integral membrane protein that belongs to the 3-O-sulfotransferases family. These proteins catalyze the addition of sulfate groups at the 3-OH position of glucosamine in heparan sulfate. The substrate specificity of individual members of the family is based on prior modification of the heparan sulfate chain, thus allowing different members of the family to generate binding sites for different proteins on the same heparan sulfate chain. Following treatment with a histone deacetylase inhibitor, expression of this gene is activated in a pancreatic cell line. The increased expression results in promotion of the epithelial-mesenchymal transition. In addition, the modification catalyzed by this protein allows herpes simplex virus membrane fusion and penetration. A very closely related homolog with an almost identical sulfotransferase domain maps less than 1 Mb away. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

GeneCards Summary for HS3ST3B1 Gene

HS3ST3B1 (Heparan Sulfate-Glucosamine 3-Sulfotransferase 3B1) is a Protein Coding gene. Diseases associated with HS3ST3B1 include herpes simplex. Among its related pathways are heparan sulfate biosynthesis and Glycosaminoglycan metabolism. GO annotations related to this gene include sulfotransferase activity and [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity. An important paralog of this gene is NDST4.

UniProtKB/Swiss-Prot for HS3ST3B1 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.

Gene Wiki entry for HS3ST3B1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HS3ST3B1 Gene

Genomics for HS3ST3B1 Gene

Regulatory Elements for HS3ST3B1 Gene

Enhancers for HS3ST3B1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HS3ST3B1 on UCSC Golden Path with GeneCards custom track

Promoters for HS3ST3B1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HS3ST3B1 on UCSC Golden Path with GeneCards custom track

Genomic Location for HS3ST3B1 Gene

Chromosome:
17
Start:
14,301,050 bp from pter
End:
14,349,406 bp from pter
Size:
48,357 bases
Orientation:
Plus strand

Genomic View for HS3ST3B1 Gene

Genes around HS3ST3B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HS3ST3B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HS3ST3B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HS3ST3B1 Gene

Proteins for HS3ST3B1 Gene

  • Protein details for HS3ST3B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y662-HS3SB_HUMAN
    Recommended name:
    Heparan sulfate glucosamine 3-O-sulfotransferase 3B1
    Protein Accession:
    Q9Y662
    Secondary Accessions:
    • B3KN58
    • D3DTS6

    Protein attributes for HS3ST3B1 Gene

    Size:
    390 amino acids
    Molecular mass:
    43324 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HS3ST3B1 Gene

Proteomics data for HS3ST3B1 Gene at MOPED

Selected DME Specific Peptides for HS3ST3B1 Gene

Post-translational modifications for HS3ST3B1 Gene

  • Glycosylation at Thr 79, Asn 258, and Asn 329
  • Modification sites at PhosphoSitePlus

Other Protein References for HS3ST3B1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for HS3ST3B1 (Heparan Sulfate Glucosamine 3-O-Sulfotransferase 3)

Domains & Families for HS3ST3B1 Gene

Gene Families for HS3ST3B1 Gene

Protein Domains for HS3ST3B1 Gene

Suggested Antigen Peptide Sequences for HS3ST3B1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y662

UniProtKB/Swiss-Prot:

HS3SB_HUMAN :
  • Belongs to the sulfotransferase 1 family.
Family:
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with HS3ST3B1: view

Function for HS3ST3B1 Gene

Molecular function for HS3ST3B1 Gene

GENATLAS Biochemistry:
heparan sulfate D-glucosamine 3-O-sulfotransferase 3B1,widely expressed with multiple transcripts active according to the saccharide structures around the GLN residue,putative regulator of heparan sulfate proteoglycan properties
UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3,5-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate.
UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.

Enzyme Numbers (IUBMB) for HS3ST3B1 Gene

genes like me logo Genes that share phenotypes with HS3ST3B1: view

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HS3ST3B1 Gene

Localization for HS3ST3B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HS3ST3B1 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HS3ST3B1 Gene COMPARTMENTS Subcellular localization image for HS3ST3B1 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 5
cytosol 1
extracellular 1
lysosome 1
mitochondrion 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for HS3ST3B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 9988767
genes like me logo Genes that share ontologies with HS3ST3B1: view

Pathways & Interactions for HS3ST3B1 Gene

genes like me logo Genes that share pathways with HS3ST3B1: view

Interacting Proteins for HS3ST3B1 Gene

Gene Ontology (GO) - Biological Process for HS3ST3B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification TAS 9988767
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with HS3ST3B1: view

No data available for SIGNOR curated interactions for HS3ST3B1 Gene

Drugs & Compounds for HS3ST3B1 Gene

(1) Drugs for HS3ST3B1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Iduronic acid Experimental Pharma 0

(2) Additional Compounds for HS3ST3B1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
1053-73-2
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
482-67-7
genes like me logo Genes that share compounds with HS3ST3B1: view

Transcripts for HS3ST3B1 Gene

mRNA/cDNA for HS3ST3B1 Gene

Unigene Clusters for HS3ST3B1 Gene

Heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HS3ST3B1 Gene

No ASD Table

Relevant External Links for HS3ST3B1 Gene

GeneLoc Exon Structure for
HS3ST3B1
ECgene alternative splicing isoforms for
HS3ST3B1

Expression for HS3ST3B1 Gene

mRNA expression in normal human tissues for HS3ST3B1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HS3ST3B1 Gene

This gene is overexpressed in Liver (x12.1) and Whole Blood (x5.4).

Protein differential expression in normal tissues from HIPED for HS3ST3B1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HS3ST3B1 Gene



SOURCE GeneReport for Unigene cluster for HS3ST3B1 Gene Hs.48384

mRNA Expression by UniProt/SwissProt for HS3ST3B1 Gene

Q9Y662-HS3SB_HUMAN
Tissue specificity: Ubiquitous. Most abundant in liver and placenta, followed by heart and kidney.
genes like me logo Genes that share expression patterns with HS3ST3B1: view

Protein tissue co-expression partners for HS3ST3B1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for HS3ST3B1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HS3ST3B1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HS3ST3B1 35
  • 88.83 (n)
  • 88.92 (a)
-- 36
  • 65 (a)
ManyToMany
HS3ST3B1 36
  • 88 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia HS3ST3B1 35
  • 92.56 (n)
  • 93.59 (a)
-- 36
  • 68 (a)
ManyToMany
-- 36
  • 94 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Hs3st3b1 35
  • 87.69 (n)
  • 88.46 (a)
Hs3st3b1 16
Hs3st3a1 36
  • 68 (a)
ManyToMany
Hs3st3b1 36
  • 88 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia HS3ST3B1 35
  • 99.57 (n)
  • 99.23 (a)
HS3ST3B1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hs3st3b1 35
  • 87.69 (n)
  • 88.21 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 63 (a)
OneToMany
chicken
(Gallus gallus)
Aves HS3ST3A1 35
  • 88.93 (n)
  • 91.02 (a)
-- 36
  • 83 (a)
ManyToMany
-- 36
  • 82 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 73 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.14458 35
zebrafish
(Danio rerio)
Actinopterygii hs3st3b1a 36
  • 61 (a)
ManyToMany
hs3st3b1b 36
  • 66 (a)
ManyToMany
si:ch211-216b21.2 36
  • 62 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7890 37
  • 66 (a)
Hs3st-B 35
  • 60.98 (n)
  • 55.78 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000422 35
  • 72.03 (n)
  • 69.41 (a)
worm
(Caenorhabditis elegans)
Secernentea hst-3 37
  • 41 (a)
Species with no ortholog for HS3ST3B1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HS3ST3B1 Gene

ENSEMBL:
Gene Tree for HS3ST3B1 (if available)
TreeFam:
Gene Tree for HS3ST3B1 (if available)

Paralogs for HS3ST3B1 Gene

(6) SIMAP similar genes for HS3ST3B1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HS3ST3B1: view

Variants for HS3ST3B1 Gene

Sequence variations from dbSNP and Humsavar for HS3ST3B1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1005321 -- 14,318,184(-) CCGAG(C/T)GGGGA intron-variant
rs1005322 -- 14,318,066(-) GATTC(C/T)GCAGG intron-variant
rs1006105 -- 14,316,719(-) GGGGA(A/G)AATGC intron-variant
rs1015663 -- 14,334,770(-) agaga(C/T)gattc intron-variant
rs720873 -- 14,342,617(-) tataa(C/T)atgct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HS3ST3B1 Gene

Variant ID Type Subtype PubMed ID
esv2664356 CNV Deletion 23128226

Variation tolerance for HS3ST3B1 Gene

Residual Variation Intolerance Score: 75.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.40; 54.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HS3ST3B1 Gene

HapMap Linkage Disequilibrium report
HS3ST3B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HS3ST3B1 Gene

Disorders for HS3ST3B1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HS3ST3B1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
herpes simplex
  • herpesvirus hominis disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HS3ST3B1

Genetic Association Database (GAD)
HS3ST3B1
Human Genome Epidemiology (HuGE) Navigator
HS3ST3B1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HS3ST3B1
genes like me logo Genes that share disorders with HS3ST3B1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HS3ST3B1 Gene

Publications for HS3ST3B1 Gene

  1. Multiple isoforms of heparan sulfate D-glucosaminyl 3-O- sulfotransferase. Isolation, characterization, and expression of human cDNAs and identification of distinct genomic loci. (PMID: 9988767) Shworak N.W. … Rosenberg R.D. (J. Biol. Chem. 1999) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. (PMID: 23291589) Lu Y. … Wong T.Y. (Nat. Genet. 2013) 3
  4. Members of 3-O-Sulfotransferases (3-OST) Family: A Valuable Tool from Zebrafish to Humans for Understanding Herpes Simplex Virus Entry. (PMID: 23358893) Baldwin J. … Tiwari V. (Open Virol J 2013) 3
  5. Genome-wide siRNA screen reveals a new cellular partner of NK cell receptor KIR2DL4: heparan sulfate directly modulates KIR2DL4-mediated responses. (PMID: 24127555) Brusilovsky M. … Porgador A. (J. Immunol. 2013) 3

Products for HS3ST3B1 Gene

Sources for HS3ST3B1 Gene

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