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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HS3ST3B1 Gene

protein-coding GIFtS: 55
GCID: GC17P014145

heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1

Explore 6 diseases affiliated with
HS3ST3B1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 3B1¹ ²		H3-OST-3B¹
3OST3B1¹ ² ³		Heparan Sulfate Glucosamine 3-O-Sulfotransferase 3B1²
30ST3B1¹ ² ⁵		EC 2.8.2.30³
Heparan Sulfate 3-O-Sulfotransferase 3B1² ³		HS3ST3B³
Heparan Sulfate D-Glucosaminyl 3-O-Sulfotransferase 3B1² ³		EC 2.8.2⁸
3-OST-3B² ³

External Ids:	HGNC: 5198¹	Entrez Gene: 9953²	Ensembl: ENSG00000125430⁷	OMIM: 604058⁵	UniProtKB: Q9Y662³

Export aliases for HS3ST3B1 gene to outside databases

Previous GC identifers: GC17P014570 GC17P015319 GC17P014147 GC17P014404 GC17P014098

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HS3ST3B1:

Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine

structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan

sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate

glucosaminyl 3-O-sulfotransferase activity. The sulfotransferase domain of this enzyme is highly similar to the same

domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1, and these two enzymes sulfate an identical

disaccharide. This gene is widely expressed, with the most abundant expression in liver and placenta. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HS3SB_HUMAN, Q9Y662

Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo

group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the

O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates

an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its

entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate

Gene Wiki entry for HS3ST3B1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010718.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HS3ST3B1 gene promoter:
USF1 USF2 USF-1:USF-2 Max CREB POU2F1 POU2F1a Zic1 USF-1 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HS3ST3B1 promoter sequence

Search SABiosciences Chromatin IP Primers for HS3ST3B1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HS3ST3B1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p12 Ensembl cytogenetic band: 17p12 HGNC cytogenetic band: 17p12

HS3ST3B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HS3ST3B1 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P014145: view genomic region (about GC identifiers)

Start:	14,204,400 bp from pter	End:	14,252,721 bp from pter
Size:	48,322 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HS3SB_HUMAN, Q9Y662 (See protein sequence)

Recommended Name: Heparan sulfate glucosamine 3-O-sulfotransferase 3B1

Size: 390 amino acids; 43324 Da

Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (Probable)

Secondary accessions: B3KN58 D3DTS6

Explore the universe of human proteins at neXtProt for HS3ST3B1: NX_Q9Y662

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y662

4/6 DME Specific Peptides for HS3ST3B1 (Q9Y662) (see all 6)

EPHFFDR

LREFYRP

TKGFPCLKK

FYFNKTKGF

HS3ST3B1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006032.1

ENSEMBL proteins:

ENSP00000436078 ENSP00000354213

Reactome Protein details: Q9Y662
Human Recombinant Protein Products for HS3ST3B1:

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	Uscn Proteins for HS3ST3B1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	9988767

HS3ST3B1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HS3ST3B1 for domains About GeneDecksing

1 InterPro domain/family:

IPR000863 Sulfotransferase_dom

Graphical View of Domain Structure for InterPro Entry Q9Y662

ProtoNet protein and cluster: Q9Y662

UniProtKB/Swiss-Prot: HS3SB_HUMAN, Q9Y662

Similarity: Belongs to the sulfotransferase 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: HS3SB_HUMAN, Q9Y662

Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo

group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the

O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates

an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its

entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate

Catalytic activity: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate +

[heparan sulfate]-glucosamine 3-sulfate

Genatlas biochemistry entry for HS3ST3B1:

heparan sulfate D-glucosamine 3-O-sulfotransferase 3B1,widely expressed with multiple transcripts active according to

the saccharide structures around the GLN residue,putative regulator of heparan sulfate proteoglycan properties

Enzyme Numbers (IUBMB): EC 2.8.2² EC 2.8.2.30¹

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity	TAS	9988767
GO:0033872	[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity	IEA	--

HS3ST3B1 for ontologies About GeneDecksing

Animal Models:

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		hsa-miR-29a hsa-miR-218 hsa-miR-183* hsa-miR-3163 hsa-miR-3606 hsa-miR-99b hsa-miR-1 hsa-miR-302f

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HS3ST3B1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

MPS IIIC - Sanfilippo syndrome C

8/16 pathways (see all 16)
MPS VI - Maroteaux-Lamy syndrome	1.00	MPS IIIA - Sanfilippo syndrome A	1.00
MPS IIIC - Sanfilippo syndrome C	1.00	MPS IIID - Sanfilippo syndrome D	1.00
MPS I - Hurler syndrome	1.00	MPS IX - Natowicz syndrome	1.00
Mucopolysaccharidoses	1.00	MPS II - Hunter syndrome	1.00

heparan sulfate biosynthesis

	heparan sulfate biosynthesis	1.00			heparan sulfate biosynthesis (late stages)	0.78
	Glycosaminoglycan biosynthesis - heparan sulfate	0.83

Disease

Disease

1.00

Metabolism

Metabolism

1.00

Biological oxidations

metapathway biotransformation

0.41

Pathway sources
See GeneCards unified pathways
Show all pathways

3 BioSystems Pathways for HS3ST3B1

	heparan sulfate biosynthesis (late stages)
	metapathway biotransformation
	heparan sulfate biosynthesis

5/18 Reactome Pathways for HS3ST3B1 (see all 18)

	MPS VI - Maroteaux-Lamy syndrome
	Metabolism
	Disease
	HS-GAG biosynthesis
	MPS II - Hunter syndrome

1 Kegg Pathway (Kegg details for HS3ST3B1):

Glycosaminoglycan biosynthesis - heparan sulfate

HS3ST3B1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for HS3ST3B1

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	TAS	--
GO:0006024	glycosaminoglycan biosynthetic process	TAS	--
GO:0015012	heparan sulfate proteoglycan biosynthetic process	TAS	9988768
GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification	TAS	9988767
GO:0030203	glycosaminoglycan metabolic process	TAS	--

HS3ST3B1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HS3ST3B1

3 HMDB Compounds for HS3ST3B1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Adenosine 3',5'-diphosphate	3,5-Diphosphoadenosine (see all 10)	1053-73-2	--
Iduronic acid	L-Iduronate (see all 3)	3402-98-0	--
Phosphoadenosine phosphosulfate	3'-Phospho-5'-adenylyl sulfate (see all 9)	482-67-7	--

Search CenterWatch for drugs/clinical trials and news about HS3ST3B1 / HS3SB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HS3ST3B1 gene:

NM_006041.1

Unigene Cluster for HS3ST3B1:

Heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1

Hs.48384 [show with all ESTs]

Unigene Representative Sequence: BC063301

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000466596 ENST00000360954(uc002goh.1)

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Additional cDNA sequence:

AF105377.1 AK023723.1 BC063301.1 BC069664.1 BC069725.1

2 DOTS entries:

DT.95233849 DT.97833448

24/76 AceView cDNA sequences (see all 76):

AA777311 NM_006041 BC063301 CD723853 AF105377 AA343703 BQ027236 BX117031

BQ004361 AA700133 AA316808 AI377884 AI184001 BG498462 BG436498 AA367804

BM693548 BX103399 AI886776 BG619865 AU139939 AA701233 AI472096 AA457270

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HS3ST3B1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTCTTTGC

About this image

HS3ST3B1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Atrioventricular Canal

Atrioventricular Canal Cells

Myocardium

Kidney

Renal Vesicle

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

See HS3ST3B1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HS3ST3B1

SOURCE GeneReport for Unigene cluster: Hs.48384

UniProtKB/Swiss-Prot: HS3SB_HUMAN, Q9Y662

Tissue specificity: Ubiquitous. Most abundant in liver and placenta, followed by heart and kidney

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for HS3ST3B1 gene from 6/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LOC769421¹	heparan sulfate glucosamine 3-O-sulfotransferase 3B1-like	84.98(n) 85.3(a)		769421 XM_003642322.1 XP_003642370.1
lizard (Anolis carolinensis)	Reptilia	--	--	68(a)	1 → many	2(106899511-106935289)
African clawed frog (Xenopus laevis)	Amphibia	Xl.14458²	Xenopus laevis transcribed sequence with moderate similarity more	77.44(n)		BJ087244.1
zebrafish (Danio rerio)	Actinopterygii	LOC100329339¹	heparan sulfate glucosamine 3-O-sulfotransferase 3A1-like	79.41(n) 87.64(a)		100329339 XM_002664008.2 XP_002664054.2
fruit fly (Drosophila melanogaster)	Insecta	CG7890³ Hs3st-B¹	heparin-glucosamine 3-O-sulfotransferase³ Heparan sulfate 3-O sulfotransferase-B¹	66(a)³ 69.14(n)¹ 66.41(a)¹		32918¹ NM_133142.1¹ NP_573370.1¹
worm (Caenorhabditis elegans)	Secernentea	hst-3³	heparan sulfate sulfotransferase	41(a)		II(6167677-6169230) --

ENSEMBL Gene Tree for HS3ST3B1 (if available)
TreeFam Gene Tree for HS3ST3B1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HS3ST3B1 gene

HS3ST2² HS3ST1² NDST2² HS3ST4² HS3ST6² HS3ST3A1² HS3ST5² NDST1²

NDST4² NDST3²

6 SIMAP similar genes for HS3ST3B1 using alignment to 1 protein entry: HS3SB_HUMAN:

HS3ST3A1 HS3ST6 HS3ST4 HS3ST2 HS3ST5 HS3ST1

HS3ST3B1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs75280274^1,2	F	--	14099958(+)	`TATTCG/CGGGCC`	1	--	int¹		1		WA	118
rs78220700^1,2		--	14100279(+)	`CACCCC/GTCCAG`	1	--	int¹		1		WA	118
rs113186063^1,2		--	14100359(+)	`CCTGTA/GCCCAC`	1	--	int¹		1		CSA	1
rs77690302^1,2	C,F	--	14100500(+)	`TGCCCA/GAGTCT`	1	--	int¹		1		EA	120
rs184728021^1,2	C	--	14100913(+)	`ATCAGA/GCACAC`	1	--	int¹		0	--	--	--	--
rs76109634^1,2	C	--	14101015(+)	`CACAGG/TAAGGC`	1	--	int¹		3		CSA WA	121
rs114609726^1,2	C,F	--	14101133(+)	`GCAGCG/AGACAG`	1	--	int¹		1		WA	118
rs118162930^1,2	C,F	--	14101542(+)	`CAAAGG/TTATGG`	1	--	int¹		1		EA	120
rs59145888^1,2	C	--	14101813(+)	`CCTAGG/TTAAAA`	1	--	int¹		1		WA	2
rs77796865^1,2	C,F	--	14101816(+)	`AGTTAA/CAACAA`	1	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for HS3ST3B1 (14204400 - 14252721 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for HS3ST3B1
1 CNV: 49816

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HS3ST3B1 for disorders           About GeneDecksing

OMIM gene information: 604058    OMIM disorders: --

6 diseases for HS3ST3B1:    About MalaCards

papillon-lefevre disease herpes simplex scoliosis pancreatic cancer

pancreatitis hepatitis

1 disease from the University of Copenhagen DISEASES database for HS3ST3B1:

Papillon-Lefevre disease

Human Genome Epidemiology (HuGE) Navigator: HS3ST3B1 (2 documents)

Export disorders for HS3ST3B1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for HS3ST3B1 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with HS3ST3B1)

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Multiple isoforms of heparan sulfate D-glucosaminyl 3-O- sulfotransferase. Isolation, characterization, and expression of human cDNAs and identification of distinct genomic loci. (PubMed id 9988767)^{1, 2, 3} Shworak N.W.... Rosenberg R.D. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities. (PubMed id 9988768)^{1, 2} Liu J.... Rosenberg R.D. (1999)
A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry. (PubMed id 10520990)^{1, 2} Shukla D.... Spear P.G. (1999)
Genetic variations in genes involved in heparan sulpha te biosynthesis are associated with Plasmodium falciparum parasitaemia: a famili al study in Burkina Faso. (PubMed id 22475533)¹ Atkinson A....Rihet P. (2012)
Heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3 B1, a novel epithelial-mesenchymal transition inducer in pancreatic cancer. (PubMed id 21709440)¹ Song K....Li P. (2011)
Heparin sulphate D-glucosaminyl 3-O-sulfotransferase 3B1 plays a role in HBV replication. (PubMed id 20705311)¹ Zhang Z....Huang A. (2010)
Analysis of copy number variation in 8,842 Korean ind ividuals reveals 39 genes associated with hepatic biomarkers AST and ALT. (PubMed id 20797317)¹ Kim H.Y....Kim H. (2010)
A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PubMed id 18464913)¹ Melzer D....Ferrucci L. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9953	HGNC: 5198	AceView: HS3ST3B1	Ensembl:ENSG00000125430	euGenes: HUgn9953
ECgene: HS3ST3B1	Kegg: 9953	H-InvDB: HS3ST3B1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HS3ST3B1	Pharmacogenomics, SNPs, Pathways
GGDB	http://riodb.ibase.aist.go.jp/rcmg/ggdb/

Intellectual Property for HS3ST3B1 gene
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Patent Information for HS3ST3B1 gene:
Search GeneIP for patents involving HS3ST3B1

GeneCards and IP:
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heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1

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HS3ST3B1 Gene

heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1

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