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Aliases for HS3ST3A1 Gene

Aliases for HS3ST3A1 Gene

  • Heparan Sulfate-Glucosamine 3-Sulfotransferase 3A1 2 3 5
  • Heparan Sulfate D-Glucosaminyl 3-O-Sulfotransferase 3A1 3 4
  • Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 3A1 2 3
  • Heparan Sulfate 3-O-Sulfotransferase 3A1 3 4
  • 3-OST-3A 3 4
  • 3OST3A1 3 4
  • Heparin-Glucosamine 3-O-Sulfotransferase 3
  • EC 2.8.2.30 4
  • H3-OST-3A 4
  • EC 2.8.2 63
  • HS3ST3A 4

External Ids for HS3ST3A1 Gene

Previous GeneCards Identifiers for HS3ST3A1 Gene

  • GC17M013765
  • GC17M014513
  • GC17M013342
  • GC17M013599
  • GC17M013339

Summaries for HS3ST3A1 Gene

Entrez Gene Summary for HS3ST3A1 Gene

  • Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. The sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1, and these two enzymes sulfate an identical disaccharide. This gene is widely expressed, with the most abundant expression in liver and placenta. [provided by RefSeq, Dec 2014]

GeneCards Summary for HS3ST3A1 Gene

HS3ST3A1 (Heparan Sulfate-Glucosamine 3-Sulfotransferase 3A1) is a Protein Coding gene. Among its related pathways are Metabolism and heparan sulfate biosynthesis. GO annotations related to this gene include sulfotransferase activity and [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity. An important paralog of this gene is NDST4.

UniProtKB/Swiss-Prot for HS3ST3A1 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.

Gene Wiki entry for HS3ST3A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HS3ST3A1 Gene

Genomics for HS3ST3A1 Gene

Regulatory Elements for HS3ST3A1 Gene

Promoters for HS3ST3A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HS3ST3A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for HS3ST3A1 Gene

Chromosome:
17
Start:
13,494,032 bp from pter
End:
13,601,974 bp from pter
Size:
107,943 bases
Orientation:
Minus strand

Genomic View for HS3ST3A1 Gene

Genes around HS3ST3A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HS3ST3A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HS3ST3A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HS3ST3A1 Gene

Proteins for HS3ST3A1 Gene

  • Protein details for HS3ST3A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y663-HS3SA_HUMAN
    Recommended name:
    Heparan sulfate glucosamine 3-O-sulfotransferase 3A1
    Protein Accession:
    Q9Y663
    Secondary Accessions:
    • A8K7N2

    Protein attributes for HS3ST3A1 Gene

    Size:
    406 amino acids
    Molecular mass:
    44900 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HS3ST3A1 Gene

neXtProt entry for HS3ST3A1 Gene

Proteomics data for HS3ST3A1 Gene at MOPED

Selected DME Specific Peptides for HS3ST3A1 Gene

Post-translational modifications for HS3ST3A1 Gene

  • Glycosylation at Asn 273 and Asn 344
  • Modification sites at PhosphoSitePlus

Other Protein References for HS3ST3A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for HS3ST3A1 Gene

Gene Families for HS3ST3A1 Gene

Protein Domains for HS3ST3A1 Gene

Suggested Antigen Peptide Sequences for HS3ST3A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y663

UniProtKB/Swiss-Prot:

HS3SA_HUMAN :
  • Belongs to the sulfotransferase 1 family.
Family:
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with HS3ST3A1: view

Function for HS3ST3A1 Gene

Molecular function for HS3ST3A1 Gene

GENATLAS Biochemistry:
heparan sulfate D-glucosamine 3-O-sulfotransferase 3A1,widely expressed with multiple transcripts active according to the saccharide structures around the GLN residue,putative regulator of heparan sulfate proteoglycan properties
UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3,5-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate.
UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.

Enzyme Numbers (IUBMB) for HS3ST3A1 Gene

Phenotypes for HS3ST3A1 Gene

genes like me logo Genes that share phenotypes with HS3ST3A1: view

Animal Model Products

CRISPR Products

miRNA for HS3ST3A1 Gene

miRTarBase miRNAs that target HS3ST3A1

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HS3ST3A1 Gene

Localization for HS3ST3A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HS3ST3A1 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HS3ST3A1 Gene COMPARTMENTS Subcellular localization image for HS3ST3A1 gene
Compartment Confidence
golgi apparatus 5
endoplasmic reticulum 1
extracellular 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for HS3ST3A1 Gene

Pathways & Interactions for HS3ST3A1 Gene

genes like me logo Genes that share pathways with HS3ST3A1: view

Interacting Proteins for HS3ST3A1 Gene

Gene Ontology (GO) - Biological Process for HS3ST3A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030203 glycosaminoglycan metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with HS3ST3A1: view

No data available for SIGNOR curated interactions for HS3ST3A1 Gene

Drugs & Compounds for HS3ST3A1 Gene

(6) Drugs for HS3ST3A1 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid Experimental Pharma Target 0
Adenosine-3'-5'-Diphosphate Experimental Pharma Target 0
N,O6-Disulfo-Glucosamine Experimental Pharma Target 0
O2-Sulfo-Glucuronic Acid Experimental Pharma Target 0
Iduronic acid Experimental Pharma 0

(2) Additional Compounds for HS3ST3A1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
1053-73-2
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
482-67-7
genes like me logo Genes that share compounds with HS3ST3A1: view

Transcripts for HS3ST3A1 Gene

Unigene Clusters for HS3ST3A1 Gene

Heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HS3ST3A1 Gene

No ASD Table

Relevant External Links for HS3ST3A1 Gene

GeneLoc Exon Structure for
HS3ST3A1
ECgene alternative splicing isoforms for
HS3ST3A1

Expression for HS3ST3A1 Gene

mRNA expression in normal human tissues for HS3ST3A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HS3ST3A1 Gene

This gene is overexpressed in Ovary (x5.5).

SOURCE GeneReport for Unigene cluster for HS3ST3A1 Gene Hs.462270

mRNA Expression by UniProt/SwissProt for HS3ST3A1 Gene

Q9Y663-HS3SA_HUMAN
Tissue specificity: Ubiquitous. Most abundant in heart and placenta, followed by liver and kidney.
genes like me logo Genes that share expression patterns with HS3ST3A1: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for HS3ST3A1 Gene

Orthologs for HS3ST3A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HS3ST3A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HS3ST3A1 35
  • 88.64 (n)
  • 87.41 (a)
-- 36
  • 87 (a)
ManyToMany
HS3ST3B1 36
  • 69 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia HS3ST3A1 35
  • 90.63 (n)
  • 89.62 (a)
-- 36
  • 90 (a)
ManyToMany
-- 36
  • 73 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Hs3st3a1 35
  • 85.41 (n)
  • 84.99 (a)
Hs3st3a1 16
Hs3st3a1 36
  • 84 (a)
ManyToMany
Hs3st3b1 36
  • 68 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia HS3ST3A1 35
  • 99.92 (n)
  • 99.75 (a)
HS3ST3A1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hs3st3a1 35
  • 84.14 (n)
  • 83.72 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 60 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 64 (a)
ManyToMany
-- 36
  • 79 (a)
ManyToMany
-- 36
  • 81 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 70 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia hs3st3a1 35
  • 74.62 (n)
  • 77.45 (a)
zebrafish
(Danio rerio)
Actinopterygii hs3st3b1a 36
  • 59 (a)
ManyToMany
hs3st3b1b 36
  • 63 (a)
ManyToMany
hs3st3l 36
  • 62 (a)
ManyToMany
si:ch211-216b21.2 36
  • 66 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7890 37
  • 62 (a)
worm
(Caenorhabditis elegans)
Secernentea hst-3 37
  • 41 (a)
Species with no ortholog for HS3ST3A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HS3ST3A1 Gene

ENSEMBL:
Gene Tree for HS3ST3A1 (if available)
TreeFam:
Gene Tree for HS3ST3A1 (if available)

Paralogs for HS3ST3A1 Gene

(7) SIMAP similar genes for HS3ST3A1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HS3ST3A1: view

Variants for HS3ST3A1 Gene

Sequence variations from dbSNP and Humsavar for HS3ST3A1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs882444 -- 13,552,478(-) GCTGT(A/C)TTGAT intron-variant
rs882445 -- 13,552,436(-) CCTGG(C/G/T)GCTTA intron-variant
rs726744 -- 13,502,263(+) GAATT(A/T)ATGGT intron-variant
rs726799 -- 13,597,079(+) CCAGA(C/T)TTGGC intron-variant, reference, synonymous-codon
rs726800 -- 13,597,287(+) AAGAG(A/G)CATAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HS3ST3A1 Gene

Variant ID Type Subtype PubMed ID
esv34170 CNV Loss 18971310
nsv833375 CNV Loss 17160897
nsv111994 CNV Loss 16902084
esv2715679 CNV Deletion 23290073
esv271959 CNV Insertion 20981092
esv273769 CNV Insertion 20981092
nsv469679 CNV Loss 16826518
nsv471696 CNV Gain+Loss 15918152

Variation tolerance for HS3ST3A1 Gene

Gene Damage Index Score: 4.15; 61.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HS3ST3A1 Gene

HapMap Linkage Disequilibrium report
HS3ST3A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HS3ST3A1 Gene

Disorders for HS3ST3A1 Gene

Relevant External Links for HS3ST3A1

Genetic Association Database (GAD)
HS3ST3A1
Human Genome Epidemiology (HuGE) Navigator
HS3ST3A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HS3ST3A1

No disorders were found for HS3ST3A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HS3ST3A1 Gene

Publications for HS3ST3A1 Gene

  1. Multiple isoforms of heparan sulfate D-glucosaminyl 3-O- sulfotransferase. Isolation, characterization, and expression of human cDNAs and identification of distinct genomic loci. (PMID: 9988767) Shworak N.W. … Rosenberg R.D. (J. Biol. Chem. 1999) 2 3 4 67
  2. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  3. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  4. Genetic variations in genes involved in heparan sulphate biosynthesis are associated with Plasmodium falciparum parasitaemia: a familial study in Burkina Faso. (PMID: 22475533) Atkinson A. … Rihet P. (Malar. J. 2012) 3
  5. Establishment of a human lung cancer cell line with high metastatic potential to multiple organs: gene expression associated with metastatic potential in human lung cancer. (PMID: 22922681) Nakano T. … Takeyoshi I. (Oncol. Rep. 2012) 3

Products for HS3ST3A1 Gene

Sources for HS3ST3A1 Gene

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