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Aliases for HS3ST3A1 Gene

Aliases for HS3ST3A1 Gene

  • Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 3A1 2 3
  • Heparan Sulfate D-Glucosaminyl 3-O-Sulfotransferase 3A1 3 4
  • Heparan Sulfate 3-O-Sulfotransferase 3A1 3 4
  • 3-OST-3A 3 4
  • 3OST3A1 3 4
  • Heparan Sulfate Glucosamine 3-O-Sulfotransferase 3A1 3
  • Heparin-Glucosamine 3-O-Sulfotransferase 3
  • EC 2.8.2.30 4
  • H3-OST-3A 4
  • EC 2.8.2 64
  • 30ST3A1 6
  • HS3ST3A 4

External Ids for HS3ST3A1 Gene

Summaries for HS3ST3A1 Gene

Entrez Gene Summary for HS3ST3A1 Gene

  • Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. The sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1, and these two enzymes sulfate an identical disaccharide. This gene is widely expressed, with the most abundant expression in liver and placenta. [provided by RefSeq, Dec 2014]

GeneCards Summary for HS3ST3A1 Gene

HS3ST3A1 (Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 3A1) is a Protein Coding gene. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include sulfotransferase activity and [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity. An important paralog of this gene is NDST4.

UniProtKB/Swiss-Prot for HS3ST3A1 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.

Gene Wiki entry for HS3ST3A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HS3ST3A1 Gene

Genomics for HS3ST3A1 Gene

Genomic Location for HS3ST3A1 Gene

Start:
13,495,689 bp from pter
End:
13,601,927 bp from pter
Size:
106,239 bases
Orientation:
Minus strand

Genomic View for HS3ST3A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HS3ST3A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HS3ST3A1 Gene

Regulatory Elements for HS3ST3A1 Gene

Proteins for HS3ST3A1 Gene

  • Protein details for HS3ST3A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y663-HS3SA_HUMAN
    Recommended name:
    Heparan sulfate glucosamine 3-O-sulfotransferase 3A1
    Protein Accession:
    Q9Y663
    Secondary Accessions:
    • A8K7N2

    Protein attributes for HS3ST3A1 Gene

    Size:
    406 amino acids
    Molecular mass:
    44900 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HS3ST3A1 Gene

neXtProt entry for HS3ST3A1 Gene

Proteomics data for HS3ST3A1 Gene at MOPED

Selected DME Specific Peptides for HS3ST3A1 Gene

Post-translational modifications for HS3ST3A1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn273 and Asn344

Other Protein References for HS3ST3A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for HS3ST3A1 Gene

Gene Families for HS3ST3A1 Gene

HGNC:
  • SULTM :Sulfotransferases, membrane-bound

Protein Domains for HS3ST3A1 Gene

UniProtKB/Swiss-Prot:

HS3SA_HUMAN
Family:
  • Belongs to the sulfotransferase 1 family.:
    • Q9Y663
genes like me logo Genes that share domains with HS3ST3A1: view

Function for HS3ST3A1 Gene

Molecular function for HS3ST3A1 Gene

GENATLAS Biochemistry: heparan sulfate D-glucosamine 3-O-sulfotransferase 3A1,widely expressed with multiple transcripts active according to the saccharide structures around the GLN residue,putative regulator of heparan sulfate proteoglycan properties
UniProtKB/Swiss-Prot CatalyticActivity: 3-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3,5-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate
UniProtKB/Swiss-Prot Function: Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.

Enzyme Numbers (IUBMB) for HS3ST3A1 Gene

Gene Ontology (GO) - Molecular Function for HS3ST3A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008146 sulfotransferase activity TAS 9988767
GO:0033872 [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity IEA --
genes like me logo Genes that share ontologies with HS3ST3A1: view

Phenotypes for HS3ST3A1 Gene

GenomeRNAi human phenotypes for HS3ST3A1:
genes like me logo Genes that share phenotypes with HS3ST3A1: view

miRNA for HS3ST3A1 Gene

miRTarBase miRNAs that target HS3ST3A1

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for HS3ST3A1 Gene

Localization for HS3ST3A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HS3ST3A1 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HS3ST3A1 Gene COMPARTMENTS Subcellular localization image for HS3ST3A1 gene
Compartment Confidence
golgi apparatus 5
endoplasmic reticulum 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HS3ST3A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HS3ST3A1: view

Pathways for HS3ST3A1 Gene

genes like me logo Genes that share pathways with HS3ST3A1: view

Interacting Proteins for HS3ST3A1 Gene

Gene Ontology (GO) - Biological Process for HS3ST3A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006024 glycosaminoglycan biosynthetic process TAS --
GO:0008152 metabolic process --
GO:0030203 glycosaminoglycan metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with HS3ST3A1: view

Compounds for HS3ST3A1 Gene

(3) HMDB Compounds for HS3ST3A1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine 3',5'-diphosphate
  • 3,5-Diphosphoadenosine
1053-73-2
Iduronic acid
  • L-Iduronate
3402-98-0
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
482-67-7

(5) Drugbank Compounds for HS3ST3A1 Gene

genes like me logo Genes that share compounds with HS3ST3A1: view

Transcripts for HS3ST3A1 Gene

Unigene Clusters for HS3ST3A1 Gene

Heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HS3ST3A1 Gene

No ASD Table

Relevant External Links for HS3ST3A1 Gene

GeneLoc Exon Structure for
HS3ST3A1
ECgene alternative splicing isoforms for
HS3ST3A1

Expression for HS3ST3A1 Gene

mRNA expression in normal human tissues for HS3ST3A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HS3ST3A1 Gene

This gene is overexpressed in Ovary (5.5).

SOURCE GeneReport for Unigene cluster for HS3ST3A1 Gene Hs.462270

mRNA Expression by UniProt/SwissProt for HS3ST3A1 Gene

Q9Y663-HS3SA_HUMAN
Tissue specificity: Ubiquitous. Most abundant in heart and placenta, followed by liver and kidney.
genes like me logo Genes that share expressions with HS3ST3A1: view

Orthologs for HS3ST3A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HS3ST3A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HS3ST3A1 36
  • 99.92 (n)
  • 99.75 (a)
HS3ST3A1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 87 (a)
ManyToMany
HS3ST3A1 36
  • 88.64 (n)
  • 87.41 (a)
HS3ST3B1 37
  • 69 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 90 (a)
ManyToMany
-- 37
  • 73 (a)
ManyToMany
HS3ST3A1 36
  • 90.63 (n)
  • 89.62 (a)
mouse
(Mus musculus)
Mammalia Hs3st3a1 36
  • 85.41 (n)
  • 84.99 (a)
Hs3st3a1 16
Hs3st3a1 37
  • 84 (a)
ManyToMany
Hs3st3b1 37
  • 68 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 60 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Hs3st3a1 36
  • 84.14 (n)
  • 83.72 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 64 (a)
ManyToMany
-- 37
  • 79 (a)
ManyToMany
-- 37
  • 81 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 70 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia hs3st3a1 36
  • 74.62 (n)
  • 77.45 (a)
zebrafish
(Danio rerio)
Actinopterygii hs3st3b1a 37
  • 59 (a)
ManyToMany
hs3st3b1b 37
  • 63 (a)
ManyToMany
hs3st3l 37
  • 62 (a)
ManyToMany
si:ch211-216b21.2 37
  • 66 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7890 38
  • 62 (a)
worm
(Caenorhabditis elegans)
Secernentea hst-3 38
  • 41 (a)
Species with no ortholog for HS3ST3A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HS3ST3A1 Gene

ENSEMBL:
Gene Tree for HS3ST3A1 (if available)
TreeFam:
Gene Tree for HS3ST3A1 (if available)

Paralogs for HS3ST3A1 Gene

Selected SIMAP similar genes for HS3ST3A1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HS3ST3A1: view

Variants for HS3ST3A1 Gene

Sequence variations from dbSNP and Humsavar for HS3ST3A1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs726744 -- 13,502,263(+) GAATT(A/T)ATGGT intron-variant
rs726799 -- 13,597,079(+) CCAGA(C/T)TTGGC intron-variant
rs726800 -- 13,597,287(+) AAGAG(A/G)CATAC intron-variant
rs726801 -- 13,597,109(+) TATAA(A/G)AAATA intron-variant
rs758222 -- 13,566,237(+) gtatc(C/T)gttat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HS3ST3A1 Gene

Variant ID Type Subtype PubMed ID
esv34170 CNV Loss 18971310
nsv833375 CNV Loss 17160897
nsv111994 CNV Loss 16902084
esv2715679 CNV Deletion 23290073
esv271959 CNV Insertion 20981092
esv273769 CNV Insertion 20981092
nsv469679 CNV Loss 16826518
nsv471696 CNV Gain+Loss 15918152

Relevant External Links for HS3ST3A1 Gene

HapMap Linkage Disequilibrium report
HS3ST3A1

Disorders for HS3ST3A1 Gene

Relevant External Links for HS3ST3A1

Genetic Association Database (GAD)
HS3ST3A1
Human Genome Epidemiology (HuGE) Navigator
HS3ST3A1
genes like me logo Genes that share disorders with HS3ST3A1: view

No data available for UniProtKB/Swiss-Prot for HS3ST3A1 Gene

Publications for HS3ST3A1 Gene

  1. Multiple isoforms of heparan sulfate D-glucosaminyl 3-O- sulfotransferase. Isolation, characterization, and expression of human cDNAs and identification of distinct genomic loci. (PMID: 9988767) Shworak N.W. … Rosenberg R.D. (J. Biol. Chem. 1999) 2 3 4
  2. Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities. (PMID: 9988768) Liu J. … Rosenberg R.D. (J. Biol. Chem. 1999) 3 4
  3. A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry. (PMID: 10520990) Shukla D. … Spear P.G. (Cell 1999) 3 4
  4. Heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3A sulfates N- unsubstituted glucosamine residues. (PMID: 10608887) Liu J. … Rosenberg R.D. (J. Biol. Chem. 1999) 3 4
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4

Products for HS3ST3A1 Gene

Sources for HS3ST3A1 Gene

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