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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HS3ST3A1 Gene

protein-coding GIFtS: 59
GCID: GC17M013339

heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1

Explore 3 diseases affiliated with
HS3ST3A1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 3A1¹ ²		H3-OST-3A¹
3OST3A1¹ ² ³		Heparan Sulfate Glucosamine 3-O-Sulfotransferase 3A1²
30ST3A1¹ ² ⁵		Heparin-Glucosamine 3-O-Sulfotransferase²
Heparan Sulfate 3-O-Sulfotransferase 3A1² ³		EC 2.8.2.30³
Heparan Sulfate D-Glucosaminyl 3-O-Sulfotransferase 3A1² ³		HS3ST3A³
3-OST-3A² ³		EC 2.8.2⁸

External Ids:	HGNC: 5196¹	Entrez Gene: 9955²	Ensembl: ENSG00000153976⁷	OMIM: 604057⁵	UniProtKB: Q9Y663³

Export aliases for HS3ST3A1 gene to outside databases

Previous GC identifers: GC17M013765 GC17M014513 GC17M013342 GC17M013599

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HS3ST3A1:

Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine

structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan

sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate

glucosaminyl 3-O-sulfotransferase activity. The sulfotransferase domain of this enzyme is highly similar to the same

domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1, and these two enzymes sulfate an identical

disaccharide. This gene is widely expressed, with the most abundant expression in liver and placenta. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HS3SA_HUMAN, Q9Y663

Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo

group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the

O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates

an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its

entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate

Gene Wiki entry for HS3ST3A1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010718.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HS3ST3A1 gene promoter:
COUP-TF1 GATA-3 COUP CUTL1 HNF-4alpha1 C/EBPalpha GATA-1 GATA-2 COUP-TF Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HS3ST3A1 promoter sequence

Search SABiosciences Chromatin IP Primers for HS3ST3A1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HS3ST3A1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p12 Ensembl cytogenetic band: 17p12 HGNC cytogenetic band: 17p12

HS3ST3A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HS3ST3A1 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M013339: view genomic region (about GC identifiers)

Start:	13,399,006 bp from pter	End:	13,505,244 bp from pter
Size:	106,239 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HS3SA_HUMAN, Q9Y663 (See protein sequence)

Recommended Name: Heparan sulfate glucosamine 3-O-sulfotransferase 3A1

Size: 406 amino acids; 44900 Da

Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (Probable)

2 PDB 3D structures from and Proteopedia for HS3ST3A1:

1T8T (3D)

1T8U (3D)

Secondary accessions: A8K7N2

Explore the universe of human proteins at neXtProt for HS3ST3A1: NX_Q9Y663

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y663

4/6 DME Specific Peptides for HS3ST3A1 (Q9Y663) (see all 6)

EPHFFDR

LREFYRP

TKGFPCLKK

FYFNKTKGF

HS3ST3A1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006033.1

ENSEMBL proteins:

ENSP00000284110 ENSP00000462696

Reactome Protein details: Q9Y663
Human Recombinant Protein Products:

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	Uscn Proteins for HS3ST3A1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	TAS	--
GO:0016021	integral to membrane	IEA	--

HS3ST3A1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for HS3ST3A1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HS3ST3A1 for domains About GeneDecksing

1 InterPro domain/family:

IPR000863 Sulfotransferase_dom

Graphical View of Domain Structure for InterPro Entry Q9Y663

ProtoNet protein and cluster: Q9Y663

UniProtKB/Swiss-Prot: HS3SA_HUMAN, Q9Y663

Similarity: Belongs to the sulfotransferase 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: HS3SA_HUMAN, Q9Y663

Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo

group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the

O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates

an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its

entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate

Catalytic activity: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate +

[heparan sulfate]-glucosamine 3-sulfate

Genatlas biochemistry entry for HS3ST3A1:

heparan sulfate D-glucosamine 3-O-sulfotransferase 3A1,widely expressed with multiple transcripts active according to

the saccharide structures around the GLN residue,putative regulator of heparan sulfate proteoglycan properties

Enzyme Numbers (IUBMB): EC 2.8.2² EC 2.8.2.30¹

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HS3ST3A1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008146	sulfotransferase activity	TAS	9988767
GO:0033872	[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity	IEA	--

HS3ST3A1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for HS3ST3A1:

Increased cell number in G1, a

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

MPS IIIC - Sanfilippo syndrome C

8/16 pathways (see all 16)
MPS VI - Maroteaux-Lamy syndrome	1.00	MPS IIIA - Sanfilippo syndrome A	1.00
MPS IIIC - Sanfilippo syndrome C	1.00	MPS IIID - Sanfilippo syndrome D	1.00
MPS I - Hurler syndrome	1.00	MPS IX - Natowicz syndrome	1.00
Mucopolysaccharidoses	1.00	MPS II - Hunter syndrome	1.00

heparan sulfate biosynthesis

	heparan sulfate biosynthesis	1.00			heparan sulfate biosynthesis (late stages)	0.78
	Glycosaminoglycan biosynthesis - heparan sulfate	0.83

Disease

Disease

1.00

Metabolism

Metabolism

1.00

Biological oxidations

metapathway biotransformation

0.41

Pathway sources
See GeneCards unified pathways
Show all pathways

3 BioSystems Pathways for HS3ST3A1

	heparan sulfate biosynthesis (late stages)
	heparan sulfate biosynthesis
	metapathway biotransformation

5/18 Reactome Pathways for HS3ST3A1 (see all 18)

	MPS VI - Maroteaux-Lamy syndrome
	Metabolism
	Disease
	HS-GAG biosynthesis
	MPS II - Hunter syndrome

1 Kegg Pathway (Kegg details for HS3ST3A1):

Glycosaminoglycan biosynthesis - heparan sulfate

HS3ST3A1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for HS3ST3A1

STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

5/20 Interacting proteins for HS3ST3A1 (ENSP00000284110⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 20)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EXT1	ENSP00000367446⁴	STRING: ENSP00000367446
EXT2	ENSP00000342656⁴	STRING: ENSP00000342656
GLCE	ENSP00000261858⁴	STRING: ENSP00000261858
GPC1	ENSP00000264039⁴	STRING: ENSP00000264039
GPC2	ENSP00000292377⁴	STRING: ENSP00000292377

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	TAS	--
GO:0006024	glycosaminoglycan biosynthetic process	TAS	--
GO:0030203	glycosaminoglycan metabolic process	TAS	--
GO:0044281	small molecule metabolic process	TAS	--

HS3ST3A1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HS3ST3A1

3 HMDB Compounds for HS3ST3A1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Adenosine 3',5'-diphosphate	3,5-Diphosphoadenosine (see all 10)	1053-73-2	--
Iduronic acid	L-Iduronate (see all 3)	3402-98-0	--
Phosphoadenosine phosphosulfate	3'-Phospho-5'-adenylyl sulfate (see all 9)	482-67-7	--

5 DrugBank Compounds for HS3ST3A1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid	--	--	target	--	17139284 17016423
Adenosine-3'-5'-Diphosphate	--	--	target	--	17139284 17016423
Citric Acid	--	77-92-9	target	--	17139284 17016423
N,O6-Disulfo-Glucosamine	--	--	target	--	17139284 17016423
O2-Sulfo-Glucuronic Acid	--	--	target	--	17139284 17016423

Search CenterWatch for drugs/clinical trials and news about HS3ST3A1 / HS3SA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HS3ST3A1 gene:

NM_006042.1

Unigene Cluster for HS3ST3A1:

Heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1

Hs.462270 [show with all ESTs]

Unigene Representative Sequence: NM_006042

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000284110(uc002gob.1) ENST00000578576

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		hsa-miR-181c hsa-miR-429 hsa-miR-181a hsa-miR-181d hsa-miR-942 hsa-miR-548t hsa-miR-656 hsa-miR-200c

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Additional cDNA sequence:

AF105376.1 AK292047.1 AY358838.1 BC044647.1

5 DOTS entries:

DT.305484 DT.95233849 DT.97825581 DT.99956000 DT.95191728

24/39 AceView cDNA sequences (see all 39):

BU619124 AU104945 BE205796 AW239403 BC044647 AY358838 CA419677 AF105376

BQ000891 CF529176 CB988412 BU557404 CB961814 CA442784 AI014841 CF593712

N59438 NM_006042 CB988186 BQ011460 BX103399 BU161930 AU099264 CA444092

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HS3ST3A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCAAGGACA

About this image

HS3ST3A1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Endocardium

Cushion Mesenchymal Cells

Endocardium

Bone

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See HS3ST3A1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HS3ST3A1

SOURCE GeneReport for Unigene cluster: Hs.462270

UniProtKB/Swiss-Prot: HS3SA_HUMAN, Q9Y663

Tissue specificity: Ubiquitous. Most abundant in heart and placenta, followed by liver and kidney

SABiosciences Custom PCR Arrays for HS3ST3A1

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HS3ST3A1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for HS3ST3A1 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	HS3ST3A1¹	heparan sulfate (glucosamine) 3-O-sulfotransferase more	89.36(n) 91.05(a)		769490 XM_001232777.2 XP_001232778.2
lizard (Anolis carolinensis)	Reptilia	--	--	65(a)	1 → many	2(106899511-106935289)
zebrafish (Danio rerio)	Actinopterygii	CR749163.1⁶ hs3st3b1b⁶ (see all 4)	-- heparan sulfate (glucosamine) 3-O-sulfotransferase... (see all 4)	65(a) 63(a) (see all 4)	many ↔ many many ↔ many (see all 4)	12(38208388-38277766) 12(38509827-38540032)
honey bee (Apis mellifera)	Insecta	--	--	67(a)	1 → many	GroupUn.157(70076-71288)
worm (Caenorhabditis elegans)	Secernentea	hst-3³	heparan sulfate sulfotransferase	41(a)		II(6167677-6169230) --

ENSEMBL Gene Tree for HS3ST3A1 (if available)
TreeFam Gene Tree for HS3ST3A1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HS3ST3A1 gene

HS3ST2² HS3ST1² NDST2² HS3ST3B1² HS3ST4² HS3ST6² HS3ST5² NDST1²

NDST4² NDST3²

7 SIMAP similar genes for HS3ST3A1 using alignment to 2 protein entries: HS3SA_HUMAN (see all proteins):

HS3ST3B1 HS3ST4 HS3ST2 HS3ST6 HS3ST1 HS3ST5

NDST2

HS3ST3A1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs16940820^1,2	C,F,H,	--	13398685(+)	`GTCTCA/CGTGGT`	1	--	int¹		14		NA NS EA CSA WA	923
rs57217155^1,2	C,F,	--	13398827(+)	`CTTCTT/CTTCCA`	1	--	int¹		1		WA	118
rs9909849^1,2	C,F,H,	--	13398860(+)	`GAAATA/GGGGAA`	1	--	int¹		20		NS EA NA WA	2310
rs138835535^1,2		--	13399031(+)	`TAATGA/TTCAAA`	1	--	ut3¹		0	--	--	--	--
rs191928954^1,2		--	13399073(+)	`GACGGG/TTACAA`	1	--	ut3¹		0	--	--	--	--
rs148886861^1,2		--	13399144(+)	`AAAATA/GTAAGG`	1	--	ut3¹		0	--	--	--	--
rs184702605^1,2		--	13399327(+)	`CTTTTC/TTGTTG`	1	--	ut3¹		0	--	--	--	--
rs190268276^1,2		--	13399364(+)	`ATTAAG/TATGGG`	1	--	ut3¹		0	--	--	--	--
rs201970798^1,2		--	13399610(+)	`CGGTCC/GATCTC`	2	I M	mis¹		0	--	--	--	--
rs62057033^1,2	C,F,	--	13399616(+)	`ATCTCA/TGGATG`	2	P	syn¹		1		EU	1260

HapMap Linkage Disequilibrium report for HS3ST3A1 (13399006 - 13505244 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for HS3ST3A1
3 CNVs: 2218 0798 47929
1 Indel: 11874

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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HS3ST3A1 for disorders           About GeneDecksing

OMIM gene information: 604057    OMIM disorders: --

3 diseases for HS3ST3A1:    About MalaCards

recurrent respiratory papillomatosis herpes simplex scoliosis

Human Genome Epidemiology (HuGE) Navigator: HS3ST3A1 (2 documents)

Export disorders for HS3ST3A1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for HS3ST3A1 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with HS3ST3A1)

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Multiple isoforms of heparan sulfate D-glucosaminyl 3-O- sulfotransferase. Isolation, characterization, and expression of human cDNAs and identification of distinct genomic loci. (PubMed id 9988767)^{1, 2, 3} Shworak N.W.... Rosenberg R.D. (1999)
Structural analysis of the sulfotransferase (3-o-sulfotransferase isoform 3) involved in the biosynthesis of an entry receptor for herpes simplex virus 1. (PubMed id 15304505)^{1, 2} Moon A.F.... Pedersen L.C. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities. (PubMed id 9988768)^{1, 2} Liu J.... Rosenberg R.D. (1999)
Heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3A sulfates N- unsubstituted glucosamine residues. (PubMed id 10608887)^{1, 2} Liu J....Rosenberg R.D. (1999)
A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry. (PubMed id 10520990)^{1, 2} Shukla D.... Spear P.G. (1999)
Genetic variations in genes involved in heparan sulpha te biosynthesis are associated with Plasmodium falciparum parasitaemia: a famili al study in Burkina Faso. (PubMed id 22475533)¹ Atkinson A....Rihet P. (2012)
A whole genome association study of mother-to-child t ransmission of HIV in Malawi. (PubMed id 20487506)¹ Joubert B.R....Meshnick S.R. (2010)
Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PubMed id 17903302)¹ Levy D....Mitchell G.F. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9955	HGNC: 5196	AceView: HS3ST3A1	Ensembl:ENSG00000153976	euGenes: HUgn9955
ECgene: HS3ST3A1	Kegg: 9955	H-InvDB: HS3ST3A1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HS3ST3A1	Pharmacogenomics, SNPs, Pathways
GGDB	http://riodb.ibase.aist.go.jp/rcmg/ggdb/

Intellectual Property for HS3ST3A1 gene
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Patent Information for HS3ST3A1 gene:
Search GeneIP for patents involving HS3ST3A1

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heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1

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HS3ST3A1 Gene

heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1

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