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Aliases for HS3ST2 Gene

Aliases for HS3ST2 Gene

  • Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 2 2 3
  • Heparan Sulfate D-Glucosaminyl 3-O-Sulfotransferase 2 3 4
  • Heparan Sulfate 3-O-Sulfotransferase 2 3 4
  • H3-OST-2 3 4
  • 3-OST-2 3 4
  • 30ST2 3 6
  • 3OST2 3 4
  • Heparan Sulfate Glucosamine 3-O-Sulfotransferase 2 3
  • Heparin-Glucosamine 3-O-Sulfotransferase 3
  • EC 2.8.2.29 4
  • EC 2.8.2 64

External Ids for HS3ST2 Gene

Summaries for HS3ST2 Gene

Entrez Gene Summary for HS3ST2 Gene

  • Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. This gene is expressed predominantly in brain and may play a role in the nervous system. [provided by RefSeq, Jul 2008]

GeneCards Summary for HS3ST2 Gene

HS3ST2 (Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 2) is a Protein Coding gene. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include sulfotransferase activity and [heparan sulfate]-glucosamine 3-sulfotransferase 2 activity. An important paralog of this gene is NDST4.

UniProtKB/Swiss-Prot for HS3ST2 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate

Gene Wiki entry for HS3ST2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HS3ST2 Gene

Genomics for HS3ST2 Gene

Genomic Location for HS3ST2 Gene

Start:
22,814,177 bp from pter
End:
22,916,338 bp from pter
Size:
102,162 bases
Orientation:
Plus strand

Genomic View for HS3ST2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HS3ST2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HS3ST2 Gene

Regulatory Elements for HS3ST2 Gene

Proteins for HS3ST2 Gene

  • Protein details for HS3ST2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y278-HS3S2_HUMAN
    Recommended name:
    Heparan sulfate glucosamine 3-O-sulfotransferase 2
    Protein Accession:
    Q9Y278
    Secondary Accessions:
    • Q52LZ1

    Protein attributes for HS3ST2 Gene

    Size:
    367 amino acids
    Molecular mass:
    41501 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HS3ST2 Gene

Proteomics data for HS3ST2 Gene at MOPED

Post-translational modifications for HS3ST2 Gene

  • Glycosylation at Asn102, Asn193, Asn235, and Asn306

Other Protein References for HS3ST2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for HS3ST2 Gene

Gene Families for HS3ST2 Gene

HGNC:
  • SULTM :Sulfotransferases, membrane-bound

Protein Domains for HS3ST2 Gene

UniProtKB/Swiss-Prot:

HS3S2_HUMAN
Family:
  • Belongs to the sulfotransferase 1 family.:
    • Q9Y278
genes like me logo Genes that share domains with HS3ST2: view

Function for HS3ST2 Gene

Molecular function for HS3ST2 Gene

GENATLAS Biochemistry: heparan sulfate D-glucosamine 3-O-sulfotransferase 2,predominantly expressed in brain,putative regulator of heparan sulfate proteoglycan properties
UniProtKB/Swiss-Prot CatalyticActivity: 3-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3,5-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate
UniProtKB/Swiss-Prot Function: Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate

Enzyme Numbers (IUBMB) for HS3ST2 Gene

Gene Ontology (GO) - Molecular Function for HS3ST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008146 sulfotransferase activity TAS 9988767
GO:0033871 [heparan sulfate]-glucosamine 3-sulfotransferase 2 activity IEA --
genes like me logo Genes that share ontologies with HS3ST2: view

Phenotypes for HS3ST2 Gene

genes like me logo Genes that share phenotypes with HS3ST2: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HS3ST2 Gene

Localization for HS3ST2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HS3ST2 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HS3ST2 Gene COMPARTMENTS Subcellular localization image for HS3ST2 gene
Compartment Confidence
golgi apparatus 5
mitochondrion 3
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for HS3ST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HS3ST2: view

Pathways for HS3ST2 Gene

genes like me logo Genes that share pathways with HS3ST2: view

Interacting Proteins for HS3ST2 Gene

Gene Ontology (GO) - Biological Process for HS3ST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006024 glycosaminoglycan biosynthetic process TAS --
GO:0007623 circadian rhythm IEA --
GO:0008152 metabolic process --
GO:0030203 glycosaminoglycan metabolic process TAS --
genes like me logo Genes that share ontologies with HS3ST2: view

Compounds for HS3ST2 Gene

(3) HMDB Compounds for HS3ST2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine 3',5'-diphosphate
  • 3,5-Diphosphoadenosine
1053-73-2
Iduronic acid
  • L-Iduronate
3402-98-0
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
482-67-7

(1) Novoseek inferred chemical compound relationships for HS3ST2 Gene

Compound -log(P) Hits PubMed IDs
heparan sulfate 75.4 3
genes like me logo Genes that share compounds with HS3ST2: view

Transcripts for HS3ST2 Gene

mRNA/cDNA for HS3ST2 Gene

Unigene Clusters for HS3ST2 Gene

Heparan sulfate (glucosamine) 3-O-sulfotransferase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HS3ST2 Gene

No ASD Table

Relevant External Links for HS3ST2 Gene

GeneLoc Exon Structure for
HS3ST2
ECgene alternative splicing isoforms for
HS3ST2

Expression for HS3ST2 Gene

mRNA expression in normal human tissues for HS3ST2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HS3ST2 Gene

This gene is overexpressed in Brain - Cortex (7.3), Brain - Anterior cingulate cortex (BA24) (7.0), Brain - Frontal Cortex (BA9) (6.7), and Artery - Aorta (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HS3ST2 Gene

SOURCE GeneReport for Unigene cluster for HS3ST2 Gene Hs.115830

mRNA Expression by UniProt/SwissProt for HS3ST2 Gene

Q9Y278-HS3S2_HUMAN
Tissue specificity: Highly expressed in the brain and weakly expressed in the heart, placenta, lung and skeletal muscle.
genes like me logo Genes that share expressions with HS3ST2: view

Orthologs for HS3ST2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HS3ST2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HS3ST2 36
  • 99.09 (n)
  • 99.73 (a)
HS3ST2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HS3ST2 36
  • 92.82 (n)
  • 96.73 (a)
HS3ST2 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HS3ST2 36
  • 91.29 (n)
  • 94.66 (a)
HS3ST2 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hs3st2 36
  • 89.37 (n)
  • 96.19 (a)
Hs3st2 16
Hs3st2 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HS3ST2 37
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hs3st2 36
  • 89.83 (n)
  • 96.19 (a)
chicken
(Gallus gallus)
Aves HS3ST2 36
  • 82.76 (n)
  • 89.35 (a)
HS3ST2 37
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HS3ST2 37
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hs3st2 36
  • 64.88 (n)
  • 68.08 (a)
zebrafish
(Danio rerio)
Actinopterygii hs3st2 36
  • 66.85 (n)
  • 71.12 (a)
hs3st2 37
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7890 38
  • 58 (a)
worm
(Caenorhabditis elegans)
Secernentea hst-3 38
  • 41 (a)
Species with no ortholog for HS3ST2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HS3ST2 Gene

ENSEMBL:
Gene Tree for HS3ST2 (if available)
TreeFam:
Gene Tree for HS3ST2 (if available)

Paralogs for HS3ST2 Gene

Selected SIMAP similar genes for HS3ST2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HS3ST2: view

Variants for HS3ST2 Gene

Sequence variations from dbSNP and Humsavar for HS3ST2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs77281 -- 22,909,183(-) TCTTG(A/G)TGGGC intron-variant
rs80946 -- 22,909,283(-) TCCCA(C/T)CTGTT intron-variant
rs150345 -- 22,816,392(+) AATAG(A/G)GGGCC intron-variant
rs150356 -- 22,837,578(+) atata(C/T)acaca intron-variant
rs169643 -- 22,868,480(-) TTCCC(A/C)CCATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HS3ST2 Gene

Variant ID Type Subtype PubMed ID
esv1412519 CNV Deletion 17803354
nsv833173 CNV Loss 17160897
esv271347 CNV Insertion 20981092
esv2667416 CNV Deletion 23128226
esv2634610 CNV Deletion 19546169
esv2666771 CNV Deletion 23128226
nsv905678 CNV Loss 21882294
esv2548215 CNV Deletion 19546169
esv2117994 CNV Deletion 18987734
esv4772 CNV Deletion 18987735
esv2714081 CNV Deletion 23290073
esv2661611 CNV Deletion 23128226
nsv103335 CNV Loss 16902084
esv8326 CNV Loss 19470904

Relevant External Links for HS3ST2 Gene

HapMap Linkage Disequilibrium report
HS3ST2

Disorders for HS3ST2 Gene

(1) Novoseek inferred disease relationships for HS3ST2 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 2

Relevant External Links for HS3ST2

Genetic Association Database (GAD)
HS3ST2
Human Genome Epidemiology (HuGE) Navigator
HS3ST2
genes like me logo Genes that share disorders with HS3ST2: view

No data available for UniProtKB/Swiss-Prot for HS3ST2 Gene

Publications for HS3ST2 Gene

  1. Multiple isoforms of heparan sulfate D-glucosaminyl 3-O- sulfotransferase. Isolation, characterization, and expression of human cDNAs and identification of distinct genomic loci. (PMID: 9988767) Shworak N.W. … Rosenberg R.D. (J. Biol. Chem. 1999) 2 3 4 23
  2. Methylation-associated silencing of heparan sulfate D-glucosaminyl 3-O-sulfotransferase-2 (3-OST-2) in human breast, colon, lung and pancreatic cancers. (PMID: 12527896) Miyamoto K. … Ushijima T. (Oncogene 2003) 3 23
  3. Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities. (PMID: 9988768) Liu J. … Rosenberg R.D. (J. Biol. Chem. 1999) 3 4
  4. A role for heparan sulfate 3-O-sulfotransferase isoform 2 in herpes simplex virus type 1 entry and spread. (PMID: 16336986) O'Donnell C.D. … Shukla D. (Virology 2006) 3 23
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4

Products for HS3ST2 Gene

Sources for HS3ST2 Gene

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