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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HS3ST2 Gene

protein-coding   GIFtS: 60
GCID: GC16P022732

Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 21 2     30ST22 5
Heparan Sulfate 3-O-Sulfotransferase 22 3     Heparan Sulfate Glucosamine 3-O-Sulfotransferase 22
Heparan Sulfate D-Glucosaminyl 3-O-Sulfotransferase 22 3     Heparin-Glucosamine 3-O-Sulfotransferase2
3-OST-22 3     EC 2.8.2.293
3OST22 3     EC 2.8.28
h3-OST-22 3     

External Ids:    HGNC: 51951   Entrez Gene: 99562   Ensembl: ENSG000001222547   OMIM: 6040565   UniProtKB: Q9Y2783   

Export aliases for HS3ST2 gene to outside databases

Previous GC identifers: GC16P022226 GC16P022834 GC16P022792 GC16P020915


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HS3ST2 Gene:
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine
structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the
heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan
sulfate glucosaminyl 3-O-sulfotransferase activity. This gene is expressed predominantly in brain and may play a
role in the nervous system. (provided by RefSeq, Jul 2008)

GeneCards Summary for HS3ST2 Gene: 
HS3ST2 (heparan sulfate (glucosamine) 3-O-sulfotransferase 2) is a protein-coding gene. Diseases associated with HS3ST2 include morquio syndrome b, and chondrosarcoma, and among its related super-pathways are Glycosaminoglycan biosynthesis - heparan sulfate / heparin and Metabolism of carbohydrates. GO annotations related to this gene include sulfotransferase activity and [heparan sulfate]-glucosamine 3-sulfotransferase 2 activity. An important paralog of this gene is ZSWIM8-AS1.

UniProtKB/Swiss-Prot: HS3S2_HUMAN, Q9Y278
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo
group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes
the O-sulfation of glucosamine in GlcA2S-GlcNS. Unlike 3-OST-1, does not convert non-anticoagulant heparan
sulfate to anticoagulant heparan sulfate

Gene Wiki entry for HS3ST2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HS3ST2 gene promoter:
         TBP   ER-alpha   RFX1   Pax-5   NRSF form 1   LUN-1   Cdc5   NRSF form 2   Evi-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHS3ST2 promoter sequence
   Search SABiosciences Chromatin IP Primers for HS3ST2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HS3ST2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12   Ensembl cytogenetic band:  16p12.2   HGNC cytogenetic band: 16p12

HS3ST2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HS3ST2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P022732:  view genomic region     (about GC identifiers)

Start:
22,825,498 bp from pter      End:
22,927,659 bp from pter
Size:
102,162 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HS3S2_HUMAN, Q9Y278 (See protein sequence)
Recommended Name: Heparan sulfate glucosamine 3-O-sulfotransferase 2  
Size: 367 amino acids; 41501 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (Probable)
Secondary accessions: Q52LZ1

Explore the universe of human proteins at neXtProt for HS3ST2: NX_Q9Y278

Explore proteomics data for HS3ST2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y278

  • 4/9 DME Specific Peptides for HS3ST2 (Q9Y278) (see all 9)
     LREFYRP  EPHFFDR  TKGFPCLKK  EKTPSYFVT 

    HS3ST2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HS3ST2 Protein Expression
    REFSEQ proteins: NP_006034.1  
    ENSEMBL proteins: 
     ENSP00000261374   ENSP00000454505  
    Reactome Protein details: Q9Y278
    Human Recombinant Protein Products for HS3ST2: 
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    Cloud-Clone Corp. Proteins for HS3ST2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0016021integral to membrane IEA--

    HS3ST2 for ontologies           About GeneDecksing



    HS3ST2 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SULTM: Sulfotransferases, membrane-bound

    2 InterPro protein domains:
     IPR000863 Sulfotransferase_dom
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q9Y278

    ProtoNet protein and cluster: Q9Y278

    UniProtKB/Swiss-Prot: HS3S2_HUMAN, Q9Y278
    Similarity: Belongs to the sulfotransferase 1 family


    HS3ST2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HS3S2_HUMAN, Q9Y278
    Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo
    group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes
    the O-sulfation of glucosamine in GlcA2S-GlcNS. Unlike 3-OST-1, does not convert non-anticoagulant heparan
    sulfate to anticoagulant heparan sulfate
    Catalytic activity: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate +
    [heparan sulfate]-glucosamine 3-sulfate

         Genatlas biochemistry entry for HS3ST2:
    heparan sulfate D-glucosamine 3-O-sulfotransferase 2,predominantly expressed in brain,putative regulator of
    heparan sulfate proteoglycan properties

         Enzyme Numbers (IUBMB): EC 2.8.22 EC 2.8.2.291

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008146sulfotransferase activity TAS9988767
    GO:0033871[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity IEA--
         
    HS3ST2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for HS3ST2:
     Decreased TP53 protein express  Increased G2M DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HS3ST2 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HS3ST2 
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    miRNA
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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate HS3ST2 (see all 13):
    hsa-miR-124* hsa-miR-498 hsa-miR-3140-3p hsa-miR-1197 hsa-miR-99b hsa-miR-548k hsa-miR-99a hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidHS3ST2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HS3ST2 About   (see all 6)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1heparan sulfate biosynthesis
    heparan sulfate biosynthesis0.79
    heparan sulfate biosynthesis (late stages)0.77
    Glycosaminoglycan biosynthesis - heparan sulfate / heparin0.79
    2MPS IIIC - Sanfilippo syndrome C
    MPS IIIC - Sanfilippo syndrome C0.48
    Mucopolysaccharidoses0.48
    MPS IV - Morquio syndrome A0.48
    MPS IIID - Sanfilippo syndrome D0.48
    MPS IV - Morquio syndrome B0.48
    MPS I - Hurler syndrome0.48
    MPS VI - Maroteaux-Lamy syndrome0.48
    MPS IX - Natowicz syndrome0.48
    3Heparan sulfate/heparin (HS-GAG) metabolism
    Heparan sulfate/heparin (HS-GAG) metabolism0.56
    HS-GAG biosynthesis0.56
    4Biological oxidations
    metapathway biotransformation0.41
    5Metabolism
    Metabolism0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for HS3ST2
        heparan sulfate biosynthesis (late stages)
    metapathway biotransformation
    heparan sulfate biosynthesis

    5/18        Reactome Pathways for HS3ST2 (see all 18)
        MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Disease
    HS-GAG biosynthesis
    MPS II - Hunter syndrome


    1         Kegg Pathway  (Kegg details for HS3ST2):
        Glycosaminoglycan biosynthesis - heparan sulfate / heparin


    HS3ST2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HS3ST2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/18 Interacting proteins for HS3ST2 (ENSP000002613744) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GLCEENSP000002618584STRING: ENSP00000261858
    GPC1ENSP000002640394STRING: ENSP00000264039
    GPC2ENSP000002923774STRING: ENSP00000292377
    GPC4ENSP000003598644STRING: ENSP00000359864
    GPC5ENSP000003662674STRING: ENSP00000366267
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006024glycosaminoglycan biosynthetic process TAS--
    GO:0007623circadian rhythm IEA--
    GO:0030203glycosaminoglycan metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    HS3ST2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HS3ST2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HS3ST2 (HS3S2)

    3 HMDB Compounds for HS3ST2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine 3',5'-diphosphate3,5-Diphosphoadenosine (see all 10)1053-73-2--
    Iduronic acidL-Iduronate (see all 3)3402-98-0--
    Phosphoadenosine phosphosulfate3'-Phospho-5'-adenylyl sulfate (see all 9)482-67-7--

    1 Novoseek inferred chemical compound relationship for HS3ST2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heparan sulfate 75.4 5 16336986 (2), 14630922 (1)

    Search CenterWatch for drugs/clinical trials and news about HS3ST2 / HS3S2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HS3ST2 gene: 
    NM_006043.1  

    Unigene Clusters for HS3ST2:

    Heparan sulfate (glucosamine) 3-O-sulfotransferase 2
    Hs.115830  [show with all ESTs], Hs.733610  [show with all ESTs]
    Unigene Representative Sequences: AY359095, BC093734
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261374(uc002dli.3) ENST00000473392
    miRNA
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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate HS3ST2 (see all 13):
    hsa-miR-124* hsa-miR-498 hsa-miR-3140-3p hsa-miR-1197 hsa-miR-99b hsa-miR-548k hsa-miR-99a hsa-miR-218
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    Additional mRNA sequence: 

    BC093734.1 BC093736.1 

    2 DOTS entries:

    DT.455720  DT.95370913 

    24/49 AceView cDNA sequences (see all 49):

    AI654820 AF105375 BM707687 NM_006043 BI756515 BX329114 Z40365 CK818832 
    CR620513 BI756381 AF003830 AI342806 BM672904 BM126801 AA541256 BX399872 
    CA440105 BM127113 BE219665 AY359095 BE502792 CK818833 BX094096 BE328042 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HS3ST2 expression in normal human tissues (normalized intensities)      HS3ST2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAATAAAT
    HS3ST2 Expression
    About this image


    HS3ST2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Thalamus
             ganglion/cranial   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Spinal Cord (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Mesoderm (Gastrulation Derivatives)
             skeleton/axial skeleton   

    See HS3ST2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HS3ST2

    SOURCE GeneReport for Unigene clusters: Hs.115830 Hs.733610

    UniProtKB/Swiss-Prot: HS3S2_HUMAN, Q9Y278
    Tissue specificity: Highly expressed in the brain and weakly expressed in the heart, placenta, lung and skeletal
    muscle

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HS3ST2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HS3ST2 gene from 6/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hs3st21 , 5 heparan sulfate (glucosamine) 3-O-sulfotransferase more1, 5 89.37(n)1
    96.19(a)1
      7 (65.07 cM)5
    1956461  NM_001081327.11  NP_001074796.11 
     1213922965 
    chicken
    (Gallus gallus)
    Aves HS3ST21 heparan sulfate (glucosamine) 3-O-sulfotransferase more 81.99(n)
    88.24(a)
      416581  XM_414882.3  XP_414882.3 
    lizard
    (Anolis carolinensis)
    Reptilia HS3ST26
    Uncharacterized protein
    66(a)
    1 ↔ 1
    GL343954.1(3107-28802)
    zebrafish
    (Danio rerio)
    Actinopterygii hs3st21 heparan sulfate (glucosamine) 3-O-sulfotransferase more 68.04(n)
    72.73(a)
      571246  NM_001080608.1  NP_001074077.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG78903 heparin-glucosamine
    3-O-sulfotransferase
    58(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea hst-33 heparan sulfate sulfotransferase 41(a)   II(6167677-6169230)   --


    ENSEMBL Gene Tree for HS3ST2 (if available)
    TreeFam Gene Tree for HS3ST2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HS3ST2 gene
    ZSWIM8-AS12  HS3ST12  HS3ST3B12  HS3ST42  HS3ST62  HS3ST52  HS3ST3A12  NDST12  
    NDST32  NDST42  
    6 SIMAP similar genes for HS3ST2 using alignment to 2 protein entries:     HS3S2_HUMAN (see all proteins):
    HS3ST3A1    HS3ST4    HS3ST6    HS3ST3B1    HS3ST5    HS3ST1

    HS3ST2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2148 SNPs in HS3ST2 are shown (see all 2148)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs346618371,2
    C--22823883(+) TGTAG-/ATTAGA 1 -- us2k10--------
    rs763194851,2
    F--22823946(+) ATTAGC/TGCATA 1 -- us2k11Minor allele frequency- T:0.09WA 118
    rs1496944631,2
    --22824029(+) ATGGTA/GACAAC 1 -- us2k10--------
    rs346480111,2
    C--22824097(+) ATTAT-/TATCTGCC 1 -- cds10--------
    rs1161159861,2
    F--22824266(+) TGGTCA/GTCTAG 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1455400791,2
    C--22824307(+) ACTCAC/TCTTGT 1 -- us2k10--------
    rs1484673161,2
    --22824442(+) CCTCAA/GGGAAG 1 -- us2k10--------
    rs22393311,2
    C,F,A,H--22824454(+) ACTGGG/AGATCG 1 -- us2k127Minor allele frequency- A:0.48EA NS NA WA CSA 4035
    rs1181133721,2
    F--22824566(+) ACTCTG/CTTTCC 1 -- us2k11Minor allele frequency- C:0.01EA 120
    rs22393321,2
    C,F,H--22824579(+) CTCCTA/GGTGTC 1 -- us2k121Minor allele frequency- G:0.16EA NS NA WA 3842

    HapMap Linkage Disequilibrium report for HS3ST2 (22825498 - 22927659 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for HS3ST2 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2117994CNV Deletion18987734
    esv2661611CNV Deletion23128226
    esv2714081CNV Deletion23290073
    esv4772CNV Deletion18987735
    esv2548215CNV Deletion19546169
    esv1412519CNV Deletion17803354
    esv2667416CNV Deletion23128226
    esv2634610CNV Deletion19546169
    esv2666771CNV Deletion23128226
    esv271347CNV Insertion20981092

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604056    OMIM disorders: --

    8 diseases for HS3ST2:    About MalaCards
    morquio syndrome b    chondrosarcoma    herpes simplex    pancreatic cancer
    schizophrenia    pancreatitis    colorectal cancer    neuronitis


    HS3ST2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for HS3ST2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 3 20098741 (2)

    Genetic Association Database (GAD): HS3ST2
    Human Genome Epidemiology (HuGE) Navigator: HS3ST2 (2 documents)

    Export disorders for HS3ST2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HS3ST2 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with HS3ST2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Multiple isoforms of heparan sulfate D-glucosaminyl 3-O- sulfotransferase. Isolation, characterization, and expression of human cDNAs and identification of distinct genomic loci. (PubMed id 9988767)1, 2, 3, 9 Shworak N.W.... Rosenberg R.D. (1999)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analy sis among pharmacogenomics, mouse expression, and genetic case-control associat ion approaches. (PubMed id 19850283)1, 4 Ikeda M....Iwata N. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    6. Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities. (PubMed id 9988768)1, 2 Liu J.... Rosenberg R.D. (1999)
    7. Methylation-associated silencing of heparan sulfate D-glucosaminyl 3-O-sulfotransferase-2 (3-OST-2) in human breast, colon, lung and pancreatic cancers. (PubMed id 12527896)1, 9 Miyamoto K....Ushijima T. (2003)
    8. A role for heparan sulfate 3-O-sulfotransferase isoform 2 in herpes simplex virus type 1 entry and spread. (PubMed id 16336986)1, 9 O'Donnell C.D....Shukla D. (2006)
    9. A genome-wide association study identifies a novel ma jor locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PubMed id 19875614)4 Paterson A.D....Bull S.B. (2010)
    10. Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20. (PubMed id 19525955)4 (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9956 HGNC: 5195 AceView: HS3ST2 Ensembl:ENSG00000122254 euGenes: HUgn9956
    ECgene: HS3ST2 Kegg: 9956 H-InvDB: HS3ST2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HS3ST2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HS3ST2 Genetics and Cytogenetics in Oncology and Haematology
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HS3ST2 gene:
    Search GeneIP for patents involving HS3ST2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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