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HS3ST1 Gene

protein-coding   GIFtS: 59
GCID: GC04M011394

Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 11 2     h3-OST-12 3
Heparan Sulfate 3-O-Sulfotransferase 12 3     EC 2.8.2.233 8
Heparan Sulfate D-Glucosaminyl 3-O-Sulfotransferase 12 3     Heparan Sulfate Glucosamine 3-O-Sulfotransferase 12
3-OST-12 3     Heparin-Glucosamine 3-O-Sulfotransferase2
3OST2 3     EC 2.8.28
3OST12 3     

External Ids:    HGNC: 51941   Entrez Gene: 99572   Ensembl: ENSG000000025877   OMIM: 6032445   UniProtKB: O147923   

Export aliases for HS3ST1 gene to outside databases

Previous GC identifers: GC04M011074 GC04M011350 GC04M011151 GC04M011076 GC04M011009 GC04M010732


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HS3ST1 Gene:
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine
structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the
heparan sulfate biosynthetic enzyme family. It possesses both heparan sulfate glucosaminyl 3-O-sulfotransferase
activity, anticoagulant heparan sulfate conversion activity, and is a rate limiting enzyme for synthesis of
anticoagulant heparan. This enzyme is an intraluminal Golgi resident protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for HS3ST1 Gene:
HS3ST1 (heparan sulfate (glucosamine) 3-O-sulfotransferase 1) is a protein-coding gene. Diseases associated with HS3ST1 include morquio syndrome b, and sly syndrome. GO annotations related to this gene include [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity and sulfotransferase activity. An important paralog of this gene is HS3ST2.

UniProtKB/Swiss-Prot: HS3S1_HUMAN, O14792
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo
group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of
heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate
as it completes the structure of the antithrombin pentasaccharide binding site

Gene Wiki entry for HS3ST1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_006316.17  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HS3ST1 gene promoter:
         c-Fos   STAT1   AP-1   Pbx1a   STAT1beta   STAT1alpha   POU2F1   POU2F1a   POU2F1b   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHS3ST1 promoter sequence
   Search Chromatin IP Primers for HS3ST1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HS3ST1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16   Ensembl cytogenetic band:  4p15.33   HGNC cytogenetic band: 4p16

HS3ST1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HS3ST1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M011394:  view genomic region     (about GC identifiers)

Start:
11,394,774 bp from pter      End:
11,431,389 bp from pter
Size:
36,616 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: HS3S1_HUMAN, O14792 (See protein sequence)
Recommended Name: Heparan sulfate glucosamine 3-O-sulfotransferase 1 precursor  
Size: 307 amino acids; 35773 Da
1 PDB 3D structure from and Proteopedia for HS3ST1:
1ZRH (3D)    
Secondary accessions: B3KUA6 Q6PEY8

Explore the universe of human proteins at neXtProt for HS3ST1: NX_O14792

Explore proteomics data for HS3ST1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn48, Asn192, Asn242, Asn249
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for HS3ST1 (O14792)
     FYFNKTKGF  KGGTRALLE  IIIGVRKGGTRALLEML 


    See HS3ST1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005105.1  
    ENSEMBL proteins: 
     ENSP00000002596   ENSP00000425673   ENSP00000422629  
    Reactome Protein details: O14792

    HS3ST1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SULTM: Sulfotransferases, membrane-bound

    2 InterPro protein domains:
     IPR000863 Sulfotransferase_dom
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry O14792

    ProtoNet protein and cluster: O14792

    UniProtKB/Swiss-Prot: HS3S1_HUMAN, O14792
    Similarity: Belongs to the sulfotransferase 1 family


    HS3ST1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HS3S1_HUMAN, O14792
    Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo
    group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of
    heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate
    as it completes the structure of the antithrombin pentasaccharide binding site
    Catalytic activity: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate +
    [heparan sulfate]-glucosamine 3-sulfate

         Enzyme Numbers (IUBMB): EC 2.8.2.231 2 EC 2.8.22

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008146sulfotransferase activity TAS9988767
    GO:0008467[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IEA--
         
    HS3ST1 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hs3st1):
     embryogenesis  growth/size/body  homeostasis/metabolism  mortality/aging 

    HS3ST1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Hs3st1tm1Nws for HS3ST1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HS3ST1
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate HS3ST1 (see all 19):
    hsa-miR-429 hsa-miR-520d-5p hsa-let-7a-2* hsa-miR-410 hsa-miR-1257 hsa-miR-3923 hsa-let-7g* hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidHS3ST1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HS3ST1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HS3S1_HUMAN, O14792: Golgi apparatus lumen (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus4
    cytosol3
    extracellular2
    endoplasmic reticulum1
    lysosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005796Golgi lumen TAS--
    GO:0016021integral component of membrane TAS9988767

    HS3ST1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HS3ST1 About   (see all 7)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1heparan sulfate biosynthesis
    heparan sulfate biosynthesis0.79
    heparan sulfate biosynthesis (late stages)0.00
    Glycosaminoglycan biosynthesis - heparan sulfate / heparin0.79
    2MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIIB - Sanfilippo syndrome B0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS II - Hunter syndrome0.45
    MPS IV - Morquio syndrome A0.45
    Glycosaminoglycan metabolism0.45
    Mucopolysaccharidoses0.45
    MPS IV - Morquio syndrome B0.45
    3Heparan sulfate/heparin (HS-GAG) metabolism
    Heparan sulfate/heparin (HS-GAG) metabolism0.57
    HS-GAG biosynthesis0.57
    4Biological oxidations
    metapathway biotransformation0.42
    5Metabolism
    Metabolism0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for HS3ST1
        Articular Cartilage Extracellular Matrix


    3 BioSystems Pathways for HS3ST1
        heparan sulfate biosynthesis (late stages)
    metapathway biotransformation
    heparan sulfate biosynthesis


    1 Reactome Pathway for HS3ST1
        HS-GAG biosynthesis


    1 Kegg Pathway  (Kegg details for HS3ST1):
        Glycosaminoglycan biosynthesis - heparan sulfate / heparin


    HS3ST1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including HS3ST1: 
              Polycomb & Trithorax Target Genes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for HS3ST1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for HS3ST1 (ENSP000000025964) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GLCEENSP000002618584STRING: ENSP00000261858
    GPC1ENSP000002640394STRING: ENSP00000264039
    GPC2ENSP000002923774STRING: ENSP00000292377
    GPC3ENSP000003598544STRING: ENSP00000359854
    GPC4ENSP000003598644STRING: ENSP00000359864
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006024glycosaminoglycan biosynthetic process TAS--
    GO:0030203glycosaminoglycan metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    HS3ST1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HS3ST1 (HS3S1)

    2 HMDB Compounds for HS3ST1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine 3',5'-diphosphate3,5-Diphosphoadenosine (see all 10)1053-73-2--
    Phosphoadenosine phosphosulfate3'-Phospho-5'-adenylyl sulfate (see all 9)482-67-7--

    1 DrugBank Compound for HS3ST1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine-3'-5'-Diphosphate-- --target--17139284 17016423 10592235

    4 Novoseek inferred chemical compound relationships for HS3ST1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heparan sulfate 83 34 15096036 (5), 16618101 (5), 16107334 (3), 19812376 (2) (see all 8)
    glucosamine 75.5 5 10608887 (2), 15096036 (1), 17075882 (1), 16618101 (1)
    3-phosphoadenosine 5'-phosphosulfate 73.8 4 16618101 (1), 11006120 (1)
    sulfate 54.5 4 10608887 (2), 9988768 (1), 17075882 (1)



    HS3ST1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HS3ST1 gene: 
    NM_005114.2  

    Unigene Cluster for HS3ST1:

    Heparan sulfate (glucosamine) 3-O-sulfotransferase 1
    Hs.507348  [show with all ESTs]
    Unigene Representative Sequence: AK096823
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000002596(uc003gmq.3) ENST00000514690 ENST00000510712
    miRNA
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    hsa-miR-429 hsa-miR-520d-5p hsa-let-7a-2* hsa-miR-410 hsa-miR-1257 hsa-miR-3923 hsa-let-7g* hsa-miR-3613-3p
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      QuantiFast Probe-based Assays in human, mouse, rat HS3ST1

    Additional mRNA sequence: 

    AF019386.1 AK096823.1 BC025735.1 BC057803.1 

    3 DOTS entries:

    DT.85105325  DT.91716636  DT.91812616 

    Selected AceView cDNA sequences (see all 61):

    BI489006 BG820479 AW007772 AA825270 BE551298 AI762633 BE712791 AI025216 
    AF019386 BM547276 CB959949 BF000296 BI524073 NM_005114 AA632194 BM763048 
    AI149235 BF115406 AW137922 BI769220 AK096823 BF732395 AI161084 BI488465 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for HS3ST1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
    SP1:                                    
    SP2:        -     -     -     -         


    ECgene alternative splicing isoforms for HS3ST1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HS3ST1 expression in normal human tissues (normalized intensities)      HS3ST1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HS3ST1 Expression
    About this image


    HS3ST1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Bone (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Cartilage (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
    HS3ST1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HS3ST1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.507348

    UniProtKB/Swiss-Prot: HS3S1_HUMAN, O14792
    Tissue specificity: Highly expressed in the brain and kidney and weakly expressed in the heart, lung and placenta

        Pathway & Disease-focused RT2 Profiler PCR Array including HS3ST1: 
              Polycomb & Trithorax Target Genes in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat HS3ST1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HS3ST1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HS3ST1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hs3st11 , 5 heparan sulfate (glucosamine) 3-O-sulfotransferase more1, 5 84.69(n)1
    88.44(a)1
      5 (21.14 cM)5
    154761  NM_010474.21  NP_034604.11 
     396139355 
    chicken
    (Gallus gallus)
    Aves HS3ST11 heparan sulfate (glucosamine) 3-O-sulfotransferase more 71.1(n)
    82.25(a)
      422840  XM_420786.4  XP_420786.1 
    lizard
    (Anolis carolinensis)
    Reptilia HS3ST16
    heparan sulfate (glucosamine) 3-O-sulfotransferase...
    77(a)
    1 ↔ 1
    GL343236.1(151830-152756)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3989712 heparan sulfate 3-O-sulfotransferase 77.07(n)    AY112700.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hs3st11 heparan sulfate (glucosamine) 3-O-sulfotransferase more 65.27(n)
    61.98(a)
      565201  NM_001080593.1  NP_001074062.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hs3st-A6
    Heparan sulfate 3-O sulfotransferase-A
    23(a)
    1 → many
    2R(14605634-14642026)
    worm
    (Caenorhabditis elegans)
    Secernentea hst-33 heparan sulfate sulfotransferase 44(a)   II(6167677-6169230)   --


    ENSEMBL Gene Tree for HS3ST1 (if available)
    TreeFam Gene Tree for HS3ST1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HS3ST1 gene
    HS3ST22  NDST22  ENSG000002729162  HS3ST3B12  HS3ST42  HS3ST62  HS3ST3A12  HS3ST52  
    NDST12  NDST42  NDST32  
    9 SIMAP similar genes for HS3ST1 using alignment to 3 protein entries:     HS3S1_HUMAN (see all proteins):
    HS3ST5    HS3ST3A1    HS3ST4    HS3ST2    HS3ST3B1    HS3ST6
    NDST2    NDST3    NDST4

    HS3ST1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HS3ST1 (see all 749)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1485691651,2
    Cuntested111341264(+) GCCATC/TGCGCA 2 N D mis11Minor allele frequency- T:0.00NA 4552
    rs1930499531,2
    --11339692(+) ACTGCA/CTGAAG 1 -- ds50010--------
    rs1857541451,2
    C--11339766(+) AGGGGC/TAGAAG 1 -- ds50010--------
    rs1379042341,2
    C--11339787(+) CTCCAG/TCCACT 1 -- ds50010--------
    rs1158979371,2
    C,F--11339927(+) GAAACA/GTACAC 1 -- ds50011Minor allele frequency- G:0.01NA 120
    rs1890171381,2
    --11340015(+) CTAAGC/GAAAAG 1 -- ds50010--------
    rs1809112911,2
    --11340135(+) CCTGGC/GGCAAA 1 -- ds50010--------
    rs1854985161,2
    --11340154(+) GTCCAA/GGATCA 1 -- ds50010--------
    rs1408107681,2
    C--11340175(+) CAAGGA/GTTTAA 1 -- ut310--------
    rs1446329191,2
    --11340193(+) TATTAC/TAACTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for HS3ST1 (11394774 - 11431389 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HS3ST1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv829862CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HS3ST1
    DNA2.0 Custom Variant and Variant Library Synthesis for HS3ST1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603244    OMIM disorders: --

    8 diseases for HS3ST1:    About MalaCards
    morquio syndrome b    sly syndrome    mucopolysaccharidoses    fatty liver disease
    chondrosarcoma    labyrinthitis    liver disease    cerebritis


    HS3ST1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): HS3ST1

    Export disorders for HS3ST1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HS3ST1 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with HS3ST1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Multiple isoforms of heparan sulfate D-glucosaminyl 3-O- sulfotransferase. Isolation, characterization, and expression of human cDNAs and identification of distinct genomic loci. (PubMed id 9988767)1, 2, 3, 9 Shworak N.W.... Rosenberg R.D. (J. Biol. Chem. 1999)
    2. Molecular cloning and expression of mouse and human cDNAs encoding heparan sulfate D-glucosaminyl 3-O-sulfotransferase. (PubMed id 9346953)1, 2, 9 Shworak N.W.... Rosenberg R.D. (J. Biol. Chem. 1997)
    3. Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities. (PubMed id 9988768)1, 2, 9 Liu J.... Rosenberg R.D. (J. Biol. Chem. 1999)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Purification of heparan sulfate D-glucosaminyl 3-O- sulfotransferase. (PubMed id 8900198)1, 2 Liu J.... Rosenberg R.D. (J. Biol. Chem. 1996)
    7. A conformational change in heparan sulfate 3-O-sulfotransferase-1 is induced by binding to heparan sulfate. (PubMed id 15096036)1, 9 Edavettal S.C....Liu J. (Biochemistry 2004)
    8. Enzymatic modification of heparan sulfate on a biochip promotes its interaction with antithrombin III. (PubMed id 11006120)1, 9 Hernaiz M....Linhardt R.J. (Biochem. Biophys. Res. Commun. 2000)
    9. Bioengineered Chinese hamster ovary cells with Golgi-targeted 3-O-sulfotransferase-1 biosynthesize heparan sulfate with an antithrombin-binding site. (PubMed id 24247246)1 Datta P....Linhardt R.J. (J. Biol. Chem. 2013)
    10. Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D. (PubMed id 22041458)4 Clark S.L....van den Oord E.J. (Psychol Med 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9957 HGNC: 5194 AceView: HS3ST1 Ensembl:ENSG00000002587 euGenes: HUgn9957
    ECgene: HS3ST1 Kegg: 9957 H-InvDB: HS3ST1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HS3ST1 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=HS3ST1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HS3ST1 gene:
    Search GeneIP for patents involving HS3ST1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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