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Aliases for HS3ST1 Gene

Aliases for HS3ST1 Gene

  • Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 1 2 3
  • Heparan Sulfate D-Glucosaminyl 3-O-Sulfotransferase 1 3 4
  • Heparan Sulfate 3-O-Sulfotransferase 1 3 4
  • EC 2.8.2.23 4 63
  • H3-OST-1 3 4
  • 3-OST-1 3 4
  • 3OST1 3 4
  • 3OST 3 4
  • Heparan Sulfate Glucosamine 3-O-Sulfotransferase 1 3
  • Heparin-Glucosamine 3-O-Sulfotransferase 3
  • EC 2.8.2 63

External Ids for HS3ST1 Gene

Previous GeneCards Identifiers for HS3ST1 Gene

  • GC04M011074
  • GC04M011350
  • GC04M011151
  • GC04M011076
  • GC04M011009
  • GC04M010732

Summaries for HS3ST1 Gene

Entrez Gene Summary for HS3ST1 Gene

  • Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It possesses both heparan sulfate glucosaminyl 3-O-sulfotransferase activity, anticoagulant heparan sulfate conversion activity, and is a rate limiting enzyme for synthesis of anticoagulant heparan. This enzyme is an intraluminal Golgi resident protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for HS3ST1 Gene

HS3ST1 (Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 1) is a Protein Coding gene. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include sulfotransferase activity and [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. An important paralog of this gene is NDST4.

UniProtKB/Swiss-Prot for HS3ST1 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site.

Gene Wiki entry for HS3ST1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HS3ST1 Gene

Genomics for HS3ST1 Gene

Regulatory Elements for HS3ST1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HS3ST1 Gene

Start:
11,393,150 bp from pter
End:
11,429,765 bp from pter
Size:
36,616 bases
Orientation:
Minus strand

Genomic View for HS3ST1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HS3ST1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HS3ST1 Gene

Proteins for HS3ST1 Gene

  • Protein details for HS3ST1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14792-HS3S1_HUMAN
    Recommended name:
    Heparan sulfate glucosamine 3-O-sulfotransferase 1
    Protein Accession:
    O14792
    Secondary Accessions:
    • B3KUA6
    • Q6PEY8

    Protein attributes for HS3ST1 Gene

    Size:
    307 amino acids
    Molecular mass:
    35773 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HS3ST1 Gene

neXtProt entry for HS3ST1 Gene

Proteomics data for HS3ST1 Gene at MOPED

Selected DME Specific Peptides for HS3ST1 Gene

Post-translational modifications for HS3ST1 Gene

  • Glycosylation at Asn48, Asn192, Asn242, and Asn249
  • Modification sites at PhosphoSitePlus

Other Protein References for HS3ST1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for HS3ST1 (Heparan Sulfate 3-O-Sulfotransferase 1/HS3ST1)

Domains for HS3ST1 Gene

Gene Families for HS3ST1 Gene

HGNC:
  • SULTM :Sulfotransferases, membrane-bound

Protein Domains for HS3ST1 Gene

Suggested Antigen Peptide Sequences for HS3ST1 Gene

Graphical View of Domain Structure for InterPro Entry

O14792

UniProtKB/Swiss-Prot:

HS3S1_HUMAN :
  • O14792
Family:
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with HS3ST1: view

Function for HS3ST1 Gene

Molecular function for HS3ST1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3,5-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate
UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site.

Enzyme Numbers (IUBMB) for HS3ST1 Gene

Gene Ontology (GO) - Molecular Function for HS3ST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008146 sulfotransferase activity TAS 9988767
GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IEA --
genes like me logo Genes that share ontologies with HS3ST1: view
genes like me logo Genes that share phenotypes with HS3ST1: view

Animal Models for HS3ST1 Gene

MGI Knock Outs for HS3ST1:

Animal Model Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for HS3ST1 Gene

Localization for HS3ST1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HS3ST1 Gene

Golgi apparatus lumen.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HS3ST1 Gene COMPARTMENTS Subcellular localization image for HS3ST1 gene
Compartment Confidence
golgi apparatus 4
cytosol 3
extracellular 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for HS3ST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005796 Golgi lumen TAS --
GO:0016021 integral component of membrane TAS 9988767
genes like me logo Genes that share ontologies with HS3ST1: view

Pathways for HS3ST1 Gene

genes like me logo Genes that share pathways with HS3ST1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for HS3ST1 Gene

Gene Ontology (GO) - Biological Process for HS3ST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006024 glycosaminoglycan biosynthetic process TAS --
GO:0030203 glycosaminoglycan metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with HS3ST1: view

Compounds for HS3ST1 Gene

(2) HMDB Compounds for HS3ST1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine 3',5'-diphosphate
  • 3,5-Diphosphoadenosine
1053-73-2
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
482-67-7

(1) Drugbank Compounds for HS3ST1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Adenosine-3'-5'-Diphosphate
target

(4) Novoseek inferred chemical compound relationships for HS3ST1 Gene

Compound -log(P) Hits PubMed IDs
heparan sulfate 83 19
glucosamine 75.5 5
3-phosphoadenosine 5-phosphosulfate 73.8 2
sulfate 54.5 4
genes like me logo Genes that share compounds with HS3ST1: view

Transcripts for HS3ST1 Gene

mRNA/cDNA for HS3ST1 Gene

Unigene Clusters for HS3ST1 Gene

Heparan sulfate (glucosamine) 3-O-sulfotransferase 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HS3ST1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HS3ST1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2: - - - -

Relevant External Links for HS3ST1 Gene

GeneLoc Exon Structure for
HS3ST1
ECgene alternative splicing isoforms for
HS3ST1

Expression for HS3ST1 Gene

mRNA expression in normal human tissues for HS3ST1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HS3ST1 Gene

This gene is overexpressed in Ovary (9.3), Brain - Cerebellar Hemisphere (6.1), and Brain - Cerebellum (5.2).

Protein differential expression in normal tissues for HS3ST1 Gene

This gene is overexpressed in Islet of Langerhans (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HS3ST1 Gene

SOURCE GeneReport for Unigene cluster for HS3ST1 Gene Hs.507348

mRNA Expression by UniProt/SwissProt for HS3ST1 Gene

O14792-HS3S1_HUMAN
Tissue specificity: Highly expressed in the brain and kidney and weakly expressed in the heart, lung and placenta.
genes like me logo Genes that share expressions with HS3ST1: view

Expression partners for HS3ST1 Gene

In Situ Assay Products

Orthologs for HS3ST1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HS3ST1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HS3ST1 35
  • 91.1 (n)
  • 91.86 (a)
HS3ST1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HS3ST1 35
  • 90.54 (n)
  • 91.7 (a)
3OST1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hs3st1 35
  • 84.69 (n)
  • 88.44 (a)
Hs3st1 16
Hs3st1 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HS3ST1 35
  • 99.46 (n)
  • 99.67 (a)
HS3ST1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hs3st1 35
  • 84.35 (n)
  • 88.1 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia HS3ST1 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves HS3ST1 35
  • 71.1 (n)
  • 82.25 (a)
HS3ST1 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HS3ST1 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hs3st1 35
  • 66.67 (n)
  • 73.38 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398971 35
zebrafish
(Danio rerio)
Actinopterygii hs3st1 35
  • 65.27 (n)
  • 61.98 (a)
hs3st1 36
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Hs3st-A 36
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hst-3 37
  • 44 (a)
hst-3.1 36
  • 38 (a)
OneToMany
Species with no ortholog for HS3ST1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HS3ST1 Gene

ENSEMBL:
Gene Tree for HS3ST1 (if available)
TreeFam:
Gene Tree for HS3ST1 (if available)

Paralogs for HS3ST1 Gene

Selected SIMAP similar genes for HS3ST1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HS3ST1: view

Variants for HS3ST1 Gene

Sequence variations from dbSNP and Humsavar for HS3ST1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs224456 -- 11,407,787(+) TTACA(A/G)ATGCA intron-variant
rs224457 -- 11,409,547(+) caaaa(C/T)gtggc intron-variant
rs224458 -- 11,410,246(+) CGTGG(A/G)AGGAA intron-variant
rs224459 -- 11,410,326(+) GGAGC(C/T)GGCAG intron-variant
rs224460 -- 11,410,505(+) ATGCT(A/G)TGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HS3ST1 Gene

Variant ID Type Subtype PubMed ID
nsv829862 CNV Gain+Loss 17160897

Relevant External Links for HS3ST1 Gene

HapMap Linkage Disequilibrium report
HS3ST1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HS3ST1 Gene

Disorders for HS3ST1 Gene

Relevant External Links for HS3ST1

Genetic Association Database (GAD)
HS3ST1

No disorders were found for HS3ST1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for HS3ST1 Gene

Publications for HS3ST1 Gene

  1. Multiple isoforms of heparan sulfate D-glucosaminyl 3-O- sulfotransferase. Isolation, characterization, and expression of human cDNAs and identification of distinct genomic loci. (PMID: 9988767) Shworak N.W. … Rosenberg R.D. (J. Biol. Chem. 1999) 2 3 4 23
  2. Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities. (PMID: 9988768) Liu J. … Rosenberg R.D. (J. Biol. Chem. 1999) 3 4 23
  3. Molecular cloning and expression of mouse and human cDNAs encoding heparan sulfate D-glucosaminyl 3-O-sulfotransferase. (PMID: 9346953) Shworak N.W. … Rosenberg R.D. (J. Biol. Chem. 1997) 3 4 23
  4. Enzymatic modification of heparan sulfate on a biochip promotes its interaction with antithrombin III. (PMID: 11006120) Hernaiz M. … Linhardt R.J. (Biochem. Biophys. Res. Commun. 2000) 3 23
  5. Purification of heparan sulfate D-glucosaminyl 3-O- sulfotransferase. (PMID: 8900198) Liu J. … Rosenberg R.D. (J. Biol. Chem. 1996) 3 4

Products for HS3ST1 Gene

Sources for HS3ST1 Gene

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