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Aliases for HS2ST1 Gene

Aliases for HS2ST1 Gene

  • Heparan Sulfate 2-O-Sulfotransferase 1 2 3
  • 2-O-Sulfotransferase 3 4
  • 2OST 3 4
  • EC 2.8.2.- 4
  • DJ604K5.2 3
  • KIAA0448 4
  • EC 2.8.2 64
  • HS2ST 4

External Ids for HS2ST1 Gene

Summaries for HS2ST1 Gene

Entrez Gene Summary for HS2ST1 Gene

  • Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes a member of the heparan sulfate biosynthetic enzyme family that transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate. The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation. Two alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Aug 2008]

GeneCards Summary for HS2ST1 Gene

HS2ST1 (Heparan Sulfate 2-O-Sulfotransferase 1) is a Protein Coding gene. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include sulfotransferase activity. An important paralog of this gene is ENSG00000267561.

UniProtKB/Swiss-Prot for HS2ST1 Gene

  • Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues (By similarity).

Gene Wiki entry for HS2ST1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HS2ST1 Gene

Genomics for HS2ST1 Gene

Genomic Location for HS2ST1 Gene

Start:
86,914,648 bp from pter
End:
87,109,998 bp from pter
Size:
195,351 bases
Orientation:
Plus strand

Genomic View for HS2ST1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HS2ST1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HS2ST1 Gene

Proteins for HS2ST1 Gene

  • Protein details for HS2ST1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7LGA3-HS2ST_HUMAN
    Recommended name:
    Heparan sulfate 2-O-sulfotransferase 1
    Protein Accession:
    Q7LGA3
    Secondary Accessions:
    • D3DT22
    • O75036
    • Q32NB5
    • Q8TAC5
    • Q9H441
    • Q9NUJ9

    Protein attributes for HS2ST1 Gene

    Size:
    356 amino acids
    Molecular mass:
    41881 Da
    Quaternary structure:
    • Homotrimer. Interacts with the C5-epimerase GLCE (By similarity).
    SequenceCaution:
    • Sequence=BAA32293.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for HS2ST1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HS2ST1 Gene

Proteomics data for HS2ST1 Gene at MOPED

Post-translational modifications for HS2ST1 Gene

Other Protein References for HS2ST1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for HS2ST1 Gene

Gene Families for HS2ST1 Gene

HGNC:
  • SULTM :Sulfotransferases, membrane-bound

Protein Domains for HS2ST1 Gene

UniProtKB/Swiss-Prot:

HS2ST_HUMAN
Family:
  • Belongs to the sulfotransferase 3 family.:
    • Q7LGA3
genes like me logo Genes that share domains with HS2ST1: view

Function for HS2ST1 Gene

Molecular function for HS2ST1 Gene

UniProtKB/Swiss-Prot Function: Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues (By similarity).

Enzyme Numbers (IUBMB) for HS2ST1 Gene

Gene Ontology (GO) - Molecular Function for HS2ST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001733 galactosylceramide sulfotransferase activity --
GO:0008146 sulfotransferase activity IEA --
genes like me logo Genes that share ontologies with HS2ST1: view
genes like me logo Genes that share phenotypes with HS2ST1: view

Animal Models for HS2ST1 Gene

MGI Knock Outs for HS2ST1:

miRNA for HS2ST1 Gene

miRTarBase miRNAs that target HS2ST1

No data available for Transcription Factor Targeting and HOMER Transcription for HS2ST1 Gene

Localization for HS2ST1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HS2ST1 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HS2ST1 Gene COMPARTMENTS Subcellular localization image for HS2ST1 gene
Compartment Confidence
golgi apparatus 5
endoplasmic reticulum 2
cytosol 1
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HS2ST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HS2ST1: view

Pathways for HS2ST1 Gene

genes like me logo Genes that share pathways with HS2ST1: view

Pathways by source for HS2ST1 Gene

Interacting Proteins for HS2ST1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000359581%0d%0a9606.ENSP00000215832%0d%0a
Selected Interacting proteins: ENSP00000359581 Q7LGA3-HS2ST_HUMAN for HS2ST1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for HS2ST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006024 glycosaminoglycan biosynthetic process TAS --
GO:0008152 metabolic process --
GO:0009058 biosynthetic process --
GO:0030203 glycosaminoglycan metabolic process TAS --
genes like me logo Genes that share ontologies with HS2ST1: view

Compounds for HS2ST1 Gene

(4) Novoseek inferred chemical compound relationships for HS2ST1 Gene

Compound -log(P) Hits PubMed IDs
heparan sulfate 84.7 6
3-phosphoadenosine 5-phosphosulfate 74.5 3
sulfate 55.5 3
chondroitin sulfate 52.9 4
genes like me logo Genes that share compounds with HS2ST1: view

Transcripts for HS2ST1 Gene

mRNA/cDNA for HS2ST1 Gene

Unigene Clusters for HS2ST1 Gene

Heparan sulfate 2-O-sulfotransferase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HS2ST1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d · 10e ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^ 14
SP1: - - - - - - - - - - - - -
SP2: - - -
SP3: - -
SP4: - -
SP5:
SP6: - - -
SP7: - - - -
SP8:
SP9:

Relevant External Links for HS2ST1 Gene

GeneLoc Exon Structure for
HS2ST1
ECgene alternative splicing isoforms for
HS2ST1

Expression for HS2ST1 Gene

mRNA expression in normal human tissues for HS2ST1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HS2ST1 Gene

SOURCE GeneReport for Unigene cluster for HS2ST1 Gene Hs.743280

genes like me logo Genes that share expressions with HS2ST1: view

Orthologs for HS2ST1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HS2ST1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HS2ST1 36
  • 99.91 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia -- 37
  • 89 (a)
OneToMany
HS2ST1 36
  • 93.76 (n)
  • 98.73 (a)
dog
(Canis familiaris)
Mammalia -- 37
  • 99 (a)
OneToMany
HS2ST1 36
  • 94.1 (n)
  • 99.16 (a)
mouse
(Mus musculus)
Mammalia Hs2st1 36
  • 88.3 (n)
  • 97.47 (a)
Hs2st1 16
Hs2st1 37
  • 97 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 99 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 96 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Hs2st1 36
  • 88.76 (n)
  • 97.47 (a)
chicken
(Gallus gallus)
Aves HS2ST1 36
  • 84.55 (n)
  • 94.1 (a)
HS2ST1 37
  • 94 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 92 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia hs2st 36
tropical clawed frog
(Silurana tropicalis)
Amphibia hs2st1 36
  • 81.65 (n)
  • 90.73 (a)
zebrafish
(Danio rerio)
Actinopterygii hs2st1a 36
  • 74.67 (n)
  • 85.03 (a)
hs2st1a 37
  • 84 (a)
ManyToMany
hs2st1b 37
  • 84 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008166 36
  • 59.34 (n)
  • 59.93 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hs2st 36
  • 57.93 (n)
  • 58.28 (a)
Hs2st 37
  • 50 (a)
OneToMany
Hs2st 38
  • 60 (a)
Sd 38
  • 60 (a)
worm
(Caenorhabditis elegans)
Secernentea hst-2 37
  • 44 (a)
OneToMany
hst-2 38
  • 50 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15173 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 44 (a)
OneToMany
Species with no ortholog for HS2ST1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HS2ST1 Gene

ENSEMBL:
Gene Tree for HS2ST1 (if available)
TreeFam:
Gene Tree for HS2ST1 (if available)

Paralogs for HS2ST1 Gene

Paralogs for HS2ST1 Gene

Selected SIMAP similar genes for HS2ST1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HS2ST1: view

Variants for HS2ST1 Gene

Sequence variations from dbSNP and Humsavar for HS2ST1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs15436 -- 87,108,137(+) TTGCA(C/T)TGTTA utr-variant-3-prime
rs472509 -- 86,922,197(+) aaggg(C/T)ttatg intron-variant
rs533981 -- 86,918,937(+) TATCT(A/G)TCCTA intron-variant
rs568243 -- 86,924,280(+) ccccc(A/C)actcc intron-variant
rs797935 -- 86,922,875(+) gtttt(C/T)attac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HS2ST1 Gene

Variant ID Type Subtype PubMed ID
esv1704081 CNV Deletion 17803354
nsv509380 CNV Insertion 20534489
esv259809 OTHER Complex 20981092
esv259535 OTHER Complex 20981092
esv1002791 CNV Insertion 20482838
esv1375917 CNV Insertion 17803354
esv1005148 CNV Insertion 20482838
nsv512744 CNV Insertion 21212237
esv2675888 CNV Deletion 23128226
esv28524 CNV Loss 19812545
esv2476077 CNV Insertion 19546169
esv271397 CNV Insertion 20981092

Relevant External Links for HS2ST1 Gene

HapMap Linkage Disequilibrium report
HS2ST1

Disorders for HS2ST1 Gene

Relevant External Links for HS2ST1

Genetic Association Database (GAD)
HS2ST1
Human Genome Epidemiology (HuGE) Navigator
HS2ST1
genes like me logo Genes that share disorders with HS2ST1: view

No data available for UniProtKB/Swiss-Prot for HS2ST1 Gene

Publications for HS2ST1 Gene

  1. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N. … Ohara O. (DNA Res. 1997) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for HS2ST1 Gene

Sources for HS2ST1 Gene

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