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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HS2ST1 Gene

protein-coding   GIFtS: 61
GCID: GC01P087380

heparan sulfate 2-O-sulfotransferase 1
 Explore 3 diseases affiliated with
HS2ST1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HS2ST1    

Aliases
for HS2ST1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Heparan Sulfate 2-O-Sulfotransferase 11 2     DJ604K5.21
KIAA04481 3     EC 2.8.2.-3
2-O-Sulfotransferase1     HS2ST3
2OST2 3     EC 2.8.28

External Ids:    HGNC: 51931   Entrez Gene: 96532   Ensembl: ENSG000001539367   OMIM: 6048445   UniProtKB: Q7LGA33   

Export aliases for HS2ST1 gene to outside databases

Previous GC identifers: GC01P087882 GC01P086549 GC01P086672 GC01P086802 GC01P087092 GC01P085491


Summaries
for HS2ST1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HS2ST1:
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine
structures that carry out multiple biologic activities. This gene encodes a member of the heparan sulfate biosynthetic
enzyme family that transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate. The disruption
of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme
may interfere with the signaling required for kidney formation. Two alternatively spliced transcript variants that
encode different proteins have been found for this gene. (provided by RefSeq, Aug 2008)

UniProtKB/Swiss-Prot: HS2ST_HUMAN, Q7LGA3
Function: Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing
heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate
in a variety of high-affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both
L-iduronyl and D-glucuronyl residues (By similarity)

Gene Wiki entry for HS2ST1


Genomic Views
for HS2ST1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HS2ST1 gene promoter:
         RREB-1   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   Meis-1b   MZF-1   FOXO4   Meis-1a   AP-2alphaA   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HS2ST1 promoter sequence
   Search SABiosciences Chromatin IP Primers for HS2ST1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HS2ST1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22.3   Ensembl cytogenetic band:  1p22.3   HGNC cytogenetic band: 1p22.3

HS2ST1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HS2ST1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P087380:  view genomic region     (about GC identifiers)

Start:
 87,380,331 bp from pter      End:
 87,602,334 bp from pter
Size:
 222,004 bases      Orientation:
 plus strand

Proteins
for HS2ST1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HS2ST_HUMAN, Q7LGA3 (See protein sequence)
Recommended Name: Heparan sulfate 2-O-sulfotransferase 1  
Size: 356 amino acids; 41881 Da
Subunit: Homotrimer. Interacts with the C5-epimerase GLCE (By similarity)
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
Sequence caution: Sequence=BAA32293.2; Type=Erroneous initiation;
Secondary accessions: D3DT22 O75036 Q32NB5 Q8TAC5 Q9H441 Q9NUJ9
Alternative splicing: 3 isoforms:  Q7LGA3-1   Q7LGA3-2   Q7LGA3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HS2ST1: NX_Q7LGA3

Post-translational modifications:

  • N-glycosylated (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q7LGA3

    • 4/13 DME Specific Peptides for HS2ST1 (Q7LGA3) (see all 13)
     YNRVPKT  NIAYDLC  PPKLQLLAV  NEYFLVGVTE 

    HS2ST1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001127964.1  NP_036394.1  

    ENSEMBL proteins: 
     ENSP00000359582   ENSP00000359581   ENSP00000467253   ENSP00000349268  
    Reactome Protein details: Q7LGA3
    Human Recombinant Protein Products: 
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    R&D Systems Recombinant & Natural Proteins for HS2ST1 (Heparan Sulfate 2-O-Sulfotransferase 1/HS2ST1)
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    Novus Biologicals HS2ST1 Proteins
    Novus Biologicals HS2ST1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HS2ST1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0016021integral to membrane IEA--


    HS2ST1 for ontologies           About GeneDecksing



    HS2ST1 Antibody Products: 
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    ThermoFisher Antibody for HS2ST1

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    Uscn ELISAs and CLIAs for HS2ST1

    Protein Domains /
    Families
    for HS2ST1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HS2ST1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR005331 Sulfotransferase
     IPR007734 Heparan_SO4_2-O-STrfase

    Graphical View of Domain Structure for InterPro Entry Q7LGA3

    ProtoNet protein and cluster: Q7LGA3

    UniProtKB/Swiss-Prot: HS2ST_HUMAN, Q7LGA3
    Similarity: Belongs to the sulfotransferase 3 family


    Function
    for HS2ST1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HS2ST_HUMAN, Q7LGA3
    Function: Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing
    heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate
    in a variety of high-affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both
    L-iduronyl and D-glucuronyl residues (By similarity)

    Enzyme Numbers (IUBMB): EC 2.8.2.-1 EC 2.8.22

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HS2ST1
    8/145 QIAGEN miScript miRNA Assays for microRNAs that regulate HS2ST1 (see all 145):
    hsa-miR-576-3p hsa-miR-140-5p hsa-miR-520f hsa-miR-106a hsa-miR-1260b hsa-miR-200b hsa-miR-761 hsa-miR-520b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene shRNA RFP: HS2ST1
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    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HS2ST1 (see all 4)
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    Cell Line
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    Search LifeMap BioReagents cell lines for HS2ST1

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HS2ST1

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004394heparan sulfate 2-O-sulfotransferase activity ----
    GO:0008146sulfotransferase activity IEA--


    HS2ST1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Hs2st1tm1.2Je for HS2ST1
         12 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Hs2st1):
     craniofacial  digestive/alimentary  endocrine/exocrine gland  homeostasis/metabolism  limbs/digits/tail 
     liver/biliary system  mortality/aging  nervous system  pigmentation  renal/urinary system 
     skeleton  vision/eye 

    HS2ST1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HS2ST1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1MPS IIIC - Sanfilippo syndrome C
    8/16 pathways (see all 16)
    		MPS IIIC - Sanfilippo syndrome C1.00
    		MPS IIID - Sanfilippo syndrome D1.00
    		MPS I - Hurler syndrome1.00
    		MPS IX - Natowicz syndrome1.00
    		Mucopolysaccharidoses1.00
    		MPS II - Hunter syndrome1.00
    		MPS IV - Morquio syndrome A1.00
    		Glycosaminoglycan metabolism1.00
    2Disease
    		Disease1.00
    3Metabolism
    		Metabolism1.00
    4Articular Cartilage Extracellular Matrix
    		Articular Cartilage Extracellular Matrix1.00
    5heparan sulfate biosynthesis
    		Glycosaminoglycan biosynthesis - heparan sulfate0.83

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 R&D Systems Pathway for HS2ST1
        Articular Cartilage Extracellular Matrix


    1 BioSystems Pathway for HS2ST1 
        metapathway biotransformation

    5/18        Reactome Pathways for HS2ST1 (see all 18)
        MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Disease
    HS-GAG biosynthesis
    MPS II - Hunter syndrome


    1         Kegg Pathway  (Kegg details for HS2ST1):
        Glycosaminoglycan biosynthesis - heparan sulfate


    HS2ST1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HS2ST1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/18 Interacting proteins for HS2ST1 (Q7LGA33 ENSP000003595814) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNIKQ9UKE53I2D: score=3 
    GLCEENSP000002618584STRING: ENSP00000261858
    GPC1ENSP000002640394STRING: ENSP00000264039
    GPC2ENSP000002923774STRING: ENSP00000292377
    GPC3ENSP000003598544STRING: ENSP00000359854
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006024glycosaminoglycan biosynthetic process TAS--
    GO:0015014heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process ----
    GO:0030202heparin metabolic process ----
    GO:0030203glycosaminoglycan metabolic process TAS--


    HS2ST1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HS2ST1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HS2ST1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HS2ST1
    4 Novoseek chemical compound relationships for HS2ST1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heparan sulfate 84.7 9 15671174 (2), 14660620 (1), 20059993 (1), 16966419 (1) (see all 5)
    3-phosphoadenosine 5'-phosphosulfate 74.5 3 16192264 (2), 11331020 (1)
    sulfate 55.5 3 16192264 (2), 11331020 (1)
    chondroitin sulfate 52.9 4 16192264 (4)

    Search CenterWatch for drugs/clinical trials and news about HS2ST1 / HS2ST 

    Transcripts
    for HS2ST1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HS2ST1 gene (2 alternative transcripts): 
    NM_001134492.1  NM_012262.3  

    Unigene Cluster for HS2ST1:

    Heparan sulfate 2-O-sulfotransferase 1
    Hs.743280  [show with all ESTs]
    Unigene Representative Sequence: NM_012262
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370551(uc001dmc.4) ENST00000370550(uc010osk.2) ENST00000591456
    ENST00000356813

    miRNA
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    8/145 QIAGEN miScript miRNA Assays for microRNAs that regulate HS2ST1 (see all 145):
    hsa-miR-576-3p hsa-miR-140-5p hsa-miR-520f hsa-miR-106a hsa-miR-1260b hsa-miR-200b hsa-miR-761 hsa-miR-520b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene shRNA RFP: HS2ST1
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    Clone
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    Additional cDNA sequence: 

    AB007917.1 AB024568.1 AF086247.1 AK023260.1 BC025384.1 BC025990.1 BC108735.1 

    12 DOTS entries:

    DT.425003  DT.100786486  DT.305898  DT.100786485  DT.97847619  DT.121398377  DT.121398361  DT.121398376 
    DT.121398406  DT.100722300  DT.102829847  DT.95125530 

    24/312 AceView cDNA sequences (see all 312):

    BU902257 AA928054 BQ433820 AI367608 W67922 BM725409 CA440056 BE669686 
    CK818841 Z39323 AI499396 AI521952 N70530 BX100291 CR604856 BM722117 
    BM782734 BE220381 AI678718 AI221327 AA731300 BF435754 AA971145 AI695769 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for HS2ST1 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d · 10e ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^ 14
    SP1:                                                  -           -     -     -     -     -     -     -     -     -           -     -     -         
    SP2:              -     -                             -                                                                                             
    SP3:              -     -                                                                                                                           
    SP4:                                                                                                  -           -                                 
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for HS2ST1

    Expression
    for HS2ST1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HS2ST1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGAAAGCACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HS2ST1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyUreteric BudUreteric Bud CellsKidney
    Lower Urinary TractUreterUreter CellsKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HS2ST1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HS2ST1

    SOURCE GeneReport for Unigene cluster: Hs.743280
        SABiosciences Custom PCR Arrays for HS2ST1
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    In Situ
    Assay Products:     
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    Orthologs
    for HS2ST1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for HS2ST1 gene from 6/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves HS2ST11 heparan sulfate 2-O-sulfotransferase 1 84.55(n)
    94.1(a)    		   395140  NM_204481.1  NP_989812.1 
    lizard
    (Anolis carolinensis)    		 Reptilia HS2ST16
    		 --
    		 93(a)
    		 1 → many
    		 4(97210022-97226459)
    African clawed frog
    (Xenopus laevis)    		 Amphibia hs2st2 heparan sulfate 2-sulfotransferase 82.55(n)    AF060179.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii hs2st1a1 heparan sulfate 2-O-sulfotransferase 1a 74.67(n)
    85.03(a)    		   791188  NM_001080670.1  NP_001074139.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Hs2st1 , 3 heparin-sulfate 2-sulfotransferase3
    heparan sulfate 2-O-sulfotransferase1    		 60(a)
    (best of 2)3
    57.92(n)1
    58.87(a)1    		   37E13
    444331  NM_057991.31  NP_477339.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea hst-23   -- 50(a)   X(11239374-11242317)   --


    ENSEMBL Gene Tree for HS2ST1 (if available)
    TreeFam Gene Tree for HS2ST1 (if available) 

    Paralogs
    for HS2ST1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HS2ST1 gene
    ENSG000002675612  UST2  
    1 SIMAP similar gene for HS2ST1 using alignment to 3 protein entries:     HS2ST_HUMAN (see all proteins):
    UST

    HS2ST1 for paralogs           About GeneDecksing



    Genomic Variants
    for HS2ST1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2990 NCBI SNPs in HS2ST1 are shown (see all 2990)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2018779121,2
    		--87382456(+) GACTC-/CTCTTGA 2 -- int10--------
    rs1870144281,2
    		--87382461(+) CTCTTC/GAAGTG 2 -- int10--------
    rs1914370571,2
    		--87382467(+) AAGTGG/TAAAGT 2 -- int10--------
    rs1457122991,2
    		--87382552(+) CACGTC/TACAGT 2 -- int10--------
    rs1836805521,2
    		--87382702(+) AATATA/GAAGTG 2 -- int10--------
    rs1891991301,2
    		--87382778(+) GACTAC/TAGATG 2 -- int10--------
    rs1930606011,2
    		--87382873(+) TTCATC/TGTAGA 2 -- int10--------
    rs781305571,2
    		F,--87382883(+) ATACTC/TGTGTT 2 -- int11Minor allele frequency- T:0.03NA 120
    rs1854759831,2
    		--87382899(+) TAAGAA/CCACCA 2 -- int10--------
    rs1899488121,2
    		--87382930(+) GACACA/GGTGGC 2 -- int10--------

    HapMap Linkage Disequilibrium report for HS2ST1 (87380331 - 87602334 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for HS2ST1
         1 CNV: 97433
         3 Indels: 74561 64148 84354

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HS2ST1
    DNA2.0 Custom Variant and Variant Library Synthesis for HS2ST1

    Disorders / Diseases
    for HS2ST1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HS2ST1 for disorders           About GeneDecksing

    OMIM gene information: 604844    OMIM disorders: --

    3 diseases for HS2ST1:    About MalaCards
    chronic lymphocytic leukemia    lymphocytic leukemia    leukemia

    Human Genome Epidemiology (HuGE) Navigator: HS2ST1 (3 documents)

    Export disorders for HS2ST1 gene to outside databases

    Publications
    for HS2ST1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HS2ST1 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with HS2ST1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2, 3 Seki N.... Ohara O. (1997)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    7. Single nucleotide polymorphisms of matrix metalloprot einase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study E piLymph. (PubMed id 21048031)1 Casabonne D....de Sanjose S. (2010)
    8. Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase. (PubMed id 17227754)1 Xu D....Liu J. (2007)
    9. Occurrence of sulfated galactans in marine angiosperms: evolutionary implications. (PubMed id 15317737)1 Aquino R.S....Mourao P.A. (2005)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for HS2ST1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HS2ST1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9653 HGNC: 5193 AceView: HS2ST1 Ensembl:ENSG00000153936 euGenes: HUgn9653
    ECgene: HS2ST1 Kegg: 9653 H-InvDB: HS2ST1

    Other Databases showing HS2ST1 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0448

    Specialized Databases showing HS2ST1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HS2ST1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HS2ST1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HS2ST1 gene:
    Search GeneIP for patents involving HS2ST1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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