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HS1BP3 Gene

protein-coding GIFtS: 53
GCID: GC02M020760

HCLS1 Binding Protein 3

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
HCLS1 Binding Protein 3¹ ²		HS1-BP3²
HSP1BP-3² ³		HCLS1-Binding Protein 3²
HS1-Binding Protein 3² ³		FLJ14249⁵
ETM2² ⁵

External Ids:	HGNC: 24979¹	Entrez Gene: 64342²	Ensembl: ENSG00000118960⁷	OMIM: 609359⁵	UniProtKB: Q53T59³

Export aliases for HS1BP3 gene to outside databases

Previous GC identifers: GC02M020740 GC02M020682 GC02M020574

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HS1BP3 Gene:

The protein encoded by this gene shares similarity with mouse Hs1bp3, an Hcls1/Hs1-interacting protein that may be

involved in lymphocyte activation. (provided by RefSeq, Jul 2008)

GeneCards Summary for HS1BP3 Gene:

HS1BP3 (HCLS1 binding protein 3) is a protein-coding gene. Diseases associated with HS1BP3 include bell's palsy, and dystonia musculorum deformans. GO annotations related to this gene include phosphatidylinositol binding.

UniProtKB/Swiss-Prot: H1BP3_HUMAN, Q53T59

Function: May be a modulator of IL-2 signaling (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000002.12 NC_018913.2 NT_022184.16

Regulatory elements:

Regulatory transcription factor binding sites in the HS1BP3 gene promoter:
Spz1 SREBP-1c MyoD AP-2gamma Cdc5 SREBP-1b SREBP-1a AP-2beta AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HS1BP3 promoter sequence

Search Chromatin IP Primers for HS1BP3

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HS1BP3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p24.1 Ensembl cytogenetic band: 2p24.1 HGNC cytogenetic band: 2p24.1

HS1BP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HS1BP3 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M020760: view genomic region (about GC identifiers)

Start:	20,760,208 bp from pter	End:	20,850,864 bp from pter
Size:	90,657 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: H1BP3_HUMAN, Q53T59 (See protein sequence)

Recommended Name: HCLS1-binding protein 3

Size: 392 amino acids; 42780 Da

Subunit: Binds HCLS1. Interacts with the SH3 domain of HCLS1 in vitro (By similarity)

Secondary accessions: B2RAW2 D6W529 Q86VC2 Q8N367

Explore the universe of human proteins at neXtProt for HS1BP3: NX_Q53T59

Explore proteomics data for HS1BP3 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See HS1BP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_071905.3

ENSEMBL proteins:

ENSP00000389960 ENSP00000387364 ENSP00000305193 ENSP00000392203 ENSP00000397546

ENSP00000384984 ENSP00000385788

HS1BP3 Human Recombinant Protein Products:

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HS1BP3 Assay Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:

IPR001683 Phox

Graphical View of Domain Structure for InterPro Entry Q53T59

ProtoNet protein and cluster: Q53T59

1 Blocks protein domain: IPB001683 Phox-like

UniProtKB/Swiss-Prot: H1BP3_HUMAN, Q53T59

Similarity: Contains 1 PX (phox homology) domain

HS1BP3 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: H1BP3_HUMAN, Q53T59

Function: May be a modulator of IL-2 signaling (By similarity)

Gene Ontology (GO): 2 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--
GO:0035091	phosphatidylinositol binding	IEA	--

HS1BP3 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HS1BP3

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HS1BP3

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HS1BP3

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HS1BP3

miRNA Products:		miRTarBase miRNAs that target HS1BP3: hsa-mir-124-3p (MIRT023188)

		Block miRNA regulation of human, mouse, rat HS1BP3 using miScript Target Protectors
		3 qRT-PCR Assays for microRNAs that regulate HS1BP3:
		hsa-miR-124 hsa-miR-506 hsa-miR-3153
		SwitchGear 3'UTR luciferase reporter plasmid: HS1BP3 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for HS1BP3
		Predesigned siRNA for gene silencing in human, mouse, rat HS1BP3

Gene Editing
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DNA2.0 Custom Protein Engineering Service for HS1BP3

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HS1BP3

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	3
cytosol	2

About this image

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for HS1BP3
Interactions:

Search GeneGlobe Interaction Network for HS1BP3

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for HS1BP3 (Q53T59³ ENSP00000305193⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HCLS1	P14317³, ENSP00000320176⁴	I2D: score=3 STRING: ENSP00000320176

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Gene Ontology (GO): 1 biological process term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007154	cell communication	--	--

HS1BP3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for HS1BP3 (H1BP3)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for HS1BP3 gene:

NM_022460.3

Unigene Cluster for HS1BP3:

HCLS1 binding protein 3

Hs.531785 [show with all ESTs]

Unigene Representative Sequence: BC050636

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000446825 ENST00000415264 ENST00000304031(uc002rdw.1) ENST00000458740

ENST00000445102 ENST00000402541(uc002rdx.3) ENST00000406618(uc002rdy.3)

miRNA Products:		Block miRNA regulation of human, mouse, rat HS1BP3 using miScript Target Protectors
		3 qRT-PCR Assays for microRNAs that regulate HS1BP3:
		hsa-miR-124 hsa-miR-506 hsa-miR-3153
		SwitchGear 3'UTR luciferase reporter plasmid: HS1BP3 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for HS1BP3
		Predesigned siRNA for gene silencing in human, mouse, rat HS1BP3

Clone Products:		OriGene clones in human, mouse for HS1BP3 (see all 5) OriGene ORF clones in mouse, rat for HS1BP3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HS1BP3 (NM_022460)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HS1BP3
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Primer Products:		OriGene qPCR primer pairs and template standards for HS1BP3 OriGene qSTAR qPCR primer pairs in human, mouse for HS1BP3
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat HS1BP3
		QuantiTect SYBR Green Assays in human, mouse, rat HS1BP3
		QuantiFast Probe-based Assays in human, mouse, rat HS1BP3

Additional mRNA sequence:

AK024311.1 AK123411.1 AK314383.1 BC038847.1 BC050636.1

7 DOTS entries:

DT.212322 DT.205801 DT.100726519 DT.95205905 DT.95293116 DT.95221633 DT.95118499

Selected AceView cDNA sequences (see all 126):

BF340358 AA913385 BQ224426 AU134068 CR596701 NM_022460 BX345340 BC038847

NM_106552 AI476172 BG150469 AW452124 BE614988 BF590885 AW073365 BM970057

BU158263 BC050636 BQ884418 CA417312 AL525113 BQ675292 BQ674057 BE614835

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for HS1BP3 (see all 6) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8a	·	8b
SP1:									-				-								-
SP2:					-		-		-				-
SP3:					-				-				-
SP4:									-
SP5:							-		-		-		-		-		-				-

ECgene alternative splicing isoforms for HS1BP3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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HS1BP3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ATTCTCTCAG

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HS1BP3 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

HS1BP3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.531785

Custom PCR Arrays for HS1BP3

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		QuantiFast Probe-based Assays in human, mouse, rat HS1BP3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HS1BP3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for HS1BP3 gene from Selected species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Hs1bp3^{1 , 5}	HCLS1 binding protein 3^{1, 5}	82.38(n)¹ 77.46(a)¹		12 (3.85 cM)⁵ 58240¹ NM_021429.3¹ NP_067404.2¹ 8313433⁵
chicken (Gallus gallus)	Aves	HS1BP3¹	HCLS1 binding protein 3	62.1(n) 58.53(a)		421966 XM_419977.4 XP_419977.4
lizard (Anolis carolinensis)	Reptilia	HS1BP3⁶	HCLS1 binding protein 3	53(a)	1 ↔ 1	1(155443889-155487551)
African clawed frog (Xenopus laevis)	Amphibia	Xl.32792²	Xenopus laevis transcribed sequence with weak similarity more	73.93(n)		CA790454.1
zebrafish (Danio rerio)	Actinopterygii	LOC553223¹	HCLS1 binding protein 3	52.22(n) 43.64(a)		553223 NM_001256221.1 NP_001243150.1

ENSEMBL Gene Tree for HS1BP3 (if available)
TreeFam Gene Tree for HS1BP3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs6739357^1,2	C,F,A	--	20817070(+)	`CGGGTG/ATGAAG`	1	--	ds500¹		3		NA CSA WA	122
rs73235063^1,2	C,F	--	20817089(+)	`CAAATG/AGGTGG`	1	--	ds500¹		3		WA NA	240
rs193224512^1,2		--	20817099(+)	`GAGCCA/GGTGCT`	1	--	ds500¹		0	--	--	--	--
rs34405290^1,2	C	--	20817188(+)	`AGTCAG/CCTCTC`	1	--	ds500¹		5		NA WA EA	362
rs138295616^1,2		--	20817260(+)	`AGGGCC/GCCACA`	1	--	ds500¹		0	--	--	--	--
rs35001606^1,2	C	--	20817261(+)	`GGGCGC/GCACAG`	1	--	ds500¹		5		NA WA EA	362
rs114349937^1,2	C,F	--	20817279(+)	`GGGACG/ATGATC`	1	--	ds500¹		1		WA	118
rs73235064^1,2	C	--	20817317(+)	`GGCACG/AGGCCA`	1	--	ds500¹		2		WA	120
rs35755927^1,2	C	--	20817362(+)	`CACCCG/ACACCA`	1	--	ds500¹		6		NA WA EA	364
rs58449730^1,2	C	--	20817393(+)	`TTTGGCTTTGG/- TGTCT`	1	--	cds¹		1		NA	2

HapMap Linkage Disequilibrium report for HS1BP3 (20760208 - 20850864 bp)

Structural Variations
Database of Genomic Variants (DGV) 7 variations for HS1BP3: About this table

Variant ID	Type	Subtype	PubMed ID
esv272408	CNV	Insertion	20981092
nsv508828	CNV	Insertion	20534489
dgv4069n71	CNV	Loss	21882294
dgv56n68	CNV	Loss	17160897
nsv527901	CNV	Loss	19592680
nsv517472	CNV	Loss	19592680
nsv873725	CNV	Loss	21882294

Human Gene Mutation Database (HGMD): HS1BP3

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing HS1BP3

DNA2.0 Custom Variant and Variant Library Synthesis for HS1BP3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 609359 OMIM disorders: --

5 diseases for HS1BP3: About MalaCards

bell's palsy dystonia musculorum deformans essential tremor tremor

parkinson's disease

2 diseases from the University of Copenhagen DISEASES database for HS1BP3:

Essential tremor Dystonia musculorum deformans

HS1BP3 for disorders About GeneDecksing

Congresses - knowledge worth sharing:
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
Genetic Association Database (GAD): HS1BP3
Human Genome Epidemiology (HuGE) Navigator: HS1BP3 (1 document)

Export disorders for HS1BP3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for HS1BP3 gene, integrated from 10 sources (see all 20):
(articles sorted by number of sources associating them with HS1BP3)

Utopia: connect your pdf to the dynamic
world of online information

A variant in the HS1-BP3 gene is associated with familial essential tremor. (PubMed id 15699368)^{1, 3, 9} Higgins J.J....Rooney J.P. (Neurology 2005)
DRD3 Ser9Gly and HS1BP3 Ala265Gly are not associated with Parkinson disease. (PubMed id 19524641)^{1, 4} Keeling B.H....Farrer M.J. (Neurosci. Lett. 2009)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
Isolation and characterization of a novel HS1 SH3 domain binding protein, HS1BP3. (PubMed id 10590261)^{1, 3} Takemoto Y....Hashimoto Y. (Int. Immunol. 1999)
VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)¹ Yu C.C....Chow L.P. (PLoS ONE 2013)
N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)² Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
Human HS1BP3 induces cell apoptosis and activates AP-1. (PubMed id 21699750)¹ Shi T....Ma D. (BMB Rep 2011)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (amp 2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 64342	HGNC: 24979	AceView: FLJ14249	Ensembl:ENSG00000118960	euGenes: HUgn64342
ECgene: HS1BP3	H-InvDB: HS1BP3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for HS1BP3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for HS1BP3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for HS1BP3 gene:
Search GeneIP for patents involving HS1BP3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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	OriGene Antibodies for HS1BP3		OriGene RNAi products in human, mouse, rat for HS1BP3
	OriGene qPCR primer pairs and template standards for HS1BP3		OriGene Protein Over-expression Lysate for HS1BP3
	OriGene MassSpec something-or-other for HS1BP3		OriGene clones in human, mouse for HS1BP3
	OriGene qSTAR qPCR primer pairs in human, mouse for HS1BP3		OriGene Purified Protein for HS1BP3
	OriGene ORF clones in mouse, rat for HS1BP3		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for HS1BP3		OriGene Custom Protein Services for HS1BP3

	Block miRNA regulation of human, mouse, rat HS1BP3 using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing HS1BP3
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HS1BP3		Predesigned siRNA for gene silencing in human, mouse, rat HS1BP3
	QuantiFast Probe-based Assays in human, mouse, rat HS1BP3		QuantiTect SYBR Green Assays in human, mouse, rat HS1BP3
	Custom PCR Arrays for HS1BP3		Search Chromatin IP Primers for HS1BP3
	Pre-validated RT² qPCR Primer Assay in human, mouse, rat HS1BP3		Search GeneGlobe Interaction Network for HS1BP3
	Regulatory tfbs in HS1BP3 promoter

	GenScript Custom Purified and Recombinant Proteins Services for HS1BP3		GenScript cDNA clones with any tag delivered in your preferred vector for HS1BP3
	GenScript Custom Assay Services for HS1BP3		GenScript Custom overexpressing Cell Line Services for HS1BP3
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

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Search Tocris compounds for HS1BP3 (H1BP3)

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	Novus Tissue Slides
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	Proteins for HS1BP3
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Browse ESI BIO Cell Lines and PureStem Progenitors for HS1BP3

	Gene Synthesis
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	Codon Optimization
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HS1BP3

	SwitchGear 3'UTR luciferase reporter plasmids for HS1BP3
	SwitchGear Promoter luciferase reporter plasmids for HS1BP3

ThermoFisher Antibodies for HS1BP3

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HS1BP3

	inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HS1BP3
	inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HS1BP3

LSBio Antibodies in human, mouse, rat for HS1BP3

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes HS1BP3 gene at Home site.

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HS1BP3 Gene

HCLS1 Binding Protein 3

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HS1BP3 Gene

HCLS1 Binding Protein 3

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for HS1BP3 gene

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for HS1BP3 gene

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for HS1BP3 gene

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for HS1BP3 gene

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for HS1BP3 gene

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for HS1BP3 gene

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for HS1BP3 gene

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