Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HS1BP3 Gene

protein-coding GIFtS: 53
GCID: GC02M020760

HCLS1 Binding Protein 3

Alzheimer's & Parkinson's Diseases Congress

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
HCLS1 Binding Protein 3¹ ²		HS1-BP3²
HSP1BP-3² ³		HCLS1-Binding Protein 3²
HS1-Binding Protein 3² ³		FLJ14249⁵
ETM2² ⁵

External Ids:	HGNC: 24979¹	Entrez Gene: 64342²	Ensembl: ENSG00000118960⁷	OMIM: 609359⁵	UniProtKB: Q53T59³

Export aliases for HS1BP3 gene to outside databases

Previous GC identifers: GC02M020740 GC02M020682 GC02M020574

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HS1BP3 Gene:

The protein encoded by this gene shares similarity with mouse Hs1bp3, an Hcls1/Hs1-interacting protein that may be

involved in lymphocyte activation. (provided by RefSeq, Jul 2008)

GeneCards Summary for HS1BP3 Gene:

HS1BP3 (HCLS1 binding protein 3) is a protein-coding gene. Diseases associated with HS1BP3 include bell's palsy, and dystonia musculorum deformans. GO annotations related to this gene include phosphatidylinositol binding.

UniProtKB/Swiss-Prot: H1BP3_HUMAN, Q53T59

Function: May be a modulator of IL-2 signaling (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NT_015926.15 NC_018913.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HS1BP3 gene promoter:
Spz1 SREBP-1c MyoD AP-2gamma Cdc5 SREBP-1b SREBP-1a AP-2beta AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HS1BP3 promoter sequence

Search SABiosciences Chromatin IP Primers for HS1BP3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HS1BP3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p24.1 Ensembl cytogenetic band: 2p24.1 HGNC cytogenetic band: 2p24.1

HS1BP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HS1BP3 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M020760: view genomic region (about GC identifiers)

Start:	20,760,208 bp from pter	End:	20,850,864 bp from pter
Size:	90,657 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: H1BP3_HUMAN, Q53T59 (See protein sequence)

Recommended Name: HCLS1-binding protein 3

Size: 392 amino acids; 42780 Da

Subunit: Binds HCLS1. Interacts with the SH3 domain of HCLS1 in vitro (By similarity)

Secondary accessions: B2RAW2 D6W529 Q86VC2 Q8N367

Explore the universe of human proteins at neXtProt for HS1BP3: NX_Q53T59

Explore proteomics data for HS1BP3 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q53T59

HS1BP3 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_071905.3

ENSEMBL proteins:

ENSP00000389960 ENSP00000387364 ENSP00000305193 ENSP00000392203 ENSP00000397546

ENSP00000384984 ENSP00000385788

Human Recombinant Protein Products for HS1BP3:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for HS1BP3 OriGene Protein Over-expression Lysate for HS1BP3 OriGene MassSpec for HS1BP3 OriGene Custom Protein Services for HS1BP3
	GenScript Custom Purified and Recombinant Proteins Services for HS1BP3
	Novus Biologicals HS1BP3 Protein Novus Biologicals HS1BP3 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for HS1BP3

HS1BP3 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies for HS1BP3 OriGene Custom Antibody Services for HS1BP3
	GenScript Custom Superior Antibodies Services for HS1BP3
	Novus Biologicals HS1BP3 Antibodies
	Abcam antibodies for HS1BP3
	Cloud-Clone Corp. Antibodies for HS1BP3
	ThermoFisher Antibodies for HS1BP3
	LSBio Antibodies in human, mouse, rat for HS1BP3

Assay Products for HS1BP3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for HS1BP3
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for HS1BP3
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for HS1BP3 Cloud-Clone Corp. CLIAs for HS1BP3

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

1 InterPro protein domain:

IPR001683 Phox

Graphical View of Domain Structure for InterPro Entry Q53T59

ProtoNet protein and cluster: Q53T59

1 Blocks protein domain: IPB001683 Phox-like

UniProtKB/Swiss-Prot: H1BP3_HUMAN, Q53T59

Similarity: Contains 1 PX (phox homology) domain

HS1BP3 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: H1BP3_HUMAN, Q53T59

Function: May be a modulator of IL-2 signaling (By similarity)

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--
GO:0035091	phosphatidylinositol binding	IEA	--

HS1BP3 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for HS1BP3

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HS1BP3

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HS1BP3

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HS1BP3

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HS1BP3
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate HS1BP3:
		hsa-miR-124 hsa-miR-506 hsa-miR-3153
		SwitchGear 3'UTR luciferase reporter plasmid: HS1BP3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for HS1BP3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HS1BP3

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for HS1BP3
			Sirion Biotech Customized adenovirus for overexpression of HS1BP3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for HS1BP3 (see all 6) OriGene ORF clones in mouse, rat for HS1BP3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HS1BP3 (NM_022460)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HS1BP3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HS1BP3
		Sirion Biotech Customized lentivirus for stable overexpression of HS1BP3 Customized lentivirus expression plasmids for stable overexpression of HS1BP3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HS1BP3
		Search LifeMap BioReagents cell lines for HS1BP3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HS1BP3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for HS1BP3

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for HS1BP3 (Q53T59³ ENSP00000305193⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HCLS1	P14317³, ENSP00000320176⁴	I2D: score=3 STRING: ENSP00000320176

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007154	cell communication	IEA	--

HS1BP3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HS1BP3 (H1BP3)

Search CenterWatch for drugs/clinical trials and news about HS1BP3 / H1BP3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HS1BP3 gene:

NM_022460.3

Unigene Cluster for HS1BP3:

HCLS1 binding protein 3

Hs.531785 [show with all ESTs]

Unigene Representative Sequence: BC050636

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000446825 ENST00000415264 ENST00000304031(uc002rdw.1) ENST00000458740

ENST00000445102 ENST00000402541(uc002rdx.3) ENST00000406618(uc002rdy.3)

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HS1BP3
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate HS1BP3:
		hsa-miR-124 hsa-miR-506 hsa-miR-3153
		SwitchGear 3'UTR luciferase reporter plasmid: HS1BP3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for HS1BP3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HS1BP3

Clone Products:		OriGene clones in human, mouse for HS1BP3 (see all 6) OriGene ORF clones in mouse, rat for HS1BP3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HS1BP3 (NM_022460)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HS1BP3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HS1BP3
		Sirion Biotech Customized lentivirus for stable overexpression of HS1BP3 Customized lentivirus expression plasmids for stable overexpression of HS1BP3

Primer Products:		OriGene qPCR primer pairs and template standards for HS1BP3 OriGene qSTAR qPCR primer pairs in human, mouse for HS1BP3
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HS1BP3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HS1BP3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HS1BP3

Additional mRNA sequence:

AK024311.1 AK123411.1 AK314383.1 BC038847.1 BC050636.1

7 DOTS entries:

DT.212322 DT.205801 DT.100726519 DT.95205905 DT.95293116 DT.95221633 DT.95118499

24/126 AceView cDNA sequences (see all 126):

BQ224426 BC038847 AI476172 BX345340 NM_022460 CR596701 BF340358 AA913385

NM_106552 AU134068 BQ673411 BM473190 BU158263 BF197459 AI333295 AI023400

BQ773417 BI256646 BF590885 CA419233 BQ073210 BF589826 BU186041 BX354596

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for HS1BP3 (see all 6) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8a	·	8b
SP1:									-				-								-
SP2:					-		-		-				-
SP3:					-				-				-
SP4:									-
SP5:							-		-		-		-		-		-				-

ECgene alternative splicing isoforms for HS1BP3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HS1BP3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ATTCTCTCAG

About this image

See HS1BP3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HS1BP3

SOURCE GeneReport for Unigene cluster: Hs.531785

SABiosciences Custom PCR Arrays for HS1BP3

Primer Products:		OriGene qPCR primer pairs and template standards for HS1BP3 OriGene qSTAR qPCR primer pairs in human, mouse for HS1BP3
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HS1BP3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HS1BP3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HS1BP3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HS1BP3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for HS1BP3 gene from 5/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Hs1bp3^{1 , 5}	HCLS1 binding protein 3^{1, 5}	82.82(n)¹ 77.98(a)¹		12 (3.85 cM)⁵ 58240¹ NM_021429.3¹ NP_067404.2¹ 8313433⁵
chicken (Gallus gallus)	Aves	HS1BP3¹	HCLS1 binding protein 3	60.87(n) 56.42(a)		421966 XM_419977.3 XP_419977.3
lizard (Anolis carolinensis)	Reptilia	HS1BP3⁶	HCLS1 binding protein 3	52(a)	1 ↔ 1	1(155443889-155487551)
African clawed frog (Xenopus laevis)	Amphibia	Xl.32792²	Xenopus laevis transcribed sequence with weak similarity more	73.93(n)		CA790454.1
zebrafish (Danio rerio)	Actinopterygii	LOC553223¹	HCLS1 binding protein 3	51.28(n) 42.31(a)		553223 XM_002665244.2 XP_002665290.1

ENSEMBL Gene Tree for HS1BP3 (if available)
TreeFam Gene Tree for HS1BP3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs6739357^1,2	C,F,A	--	20817070(+)	`CGGGTG/ATGAAG`	1	--	ds500¹		3		NA CSA WA	122
rs73235063^1,2	C,F	--	20817089(+)	`CAAATG/AGGTGG`	1	--	ds500¹		3		WA NA	240
rs193224512^1,2		--	20817099(+)	`GAGCCA/GGTGCT`	1	--	ds500¹		0	--	--	--	--
rs34405290^1,2	C	--	20817188(+)	`AGTCAG/CCTCTC`	1	--	ds500¹		5		NA WA EA	362
rs138295616^1,2		--	20817260(+)	`AGGGCC/GCCACA`	1	--	ds500¹		0	--	--	--	--
rs35001606^1,2	C	--	20817261(+)	`GGGCGC/GCACAG`	1	--	ds500¹		5		NA WA EA	362
rs114349937^1,2	C,F	--	20817279(+)	`GGGACG/ATGATC`	1	--	ds500¹		1		WA	118
rs73235064^1,2	C	--	20817317(+)	`GGCACG/AGGCCA`	1	--	ds500¹		2		WA	120
rs35755927^1,2	C	--	20817362(+)	`CACCCG/ACACCA`	1	--	ds500¹		6		NA WA EA	364
rs58449730^1,2	C	--	20817393(+)	`TTTGGCTTTGG/- TGTCT`	1	--	cds¹		1		NA	2

HapMap Linkage Disequilibrium report for HS1BP3 (20760208 - 20850864 bp)

Structural Variations
Database of Genomic Variants (DGV) 7 variations for HS1BP3: About this table

Variant ID	Type	Subtype	PubMed ID
esv272408	CNV	Insertion	20981092
nsv508828	CNV	Insertion	20534489
dgv4069n71	CNV	Loss	21882294
dgv56n68	CNV	Loss	17160897
nsv527901	CNV	Loss	19592680
nsv517472	CNV	Loss	19592680
nsv873725	CNV	Loss	21882294

Human Gene Mutation Database (HGMD): HS1BP3

SABiosciences Cancer Mutation PCR Assays

SeqTarget long-range PCR primers for resequencing HS1BP3

DNA2.0 Custom Variant and Variant Library Synthesis for HS1BP3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 609359 OMIM disorders: --

5 diseases for HS1BP3: About MalaCards

bell's palsy dystonia musculorum deformans essential tremor tremor

parkinson's disease

2 diseases from the University of Copenhagen DISEASES database for HS1BP3:

Essential tremor Dystonia musculorum deformans

HS1BP3 for disorders About GeneDecksing

Congresses - knowledge worth sharing:
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
Genetic Association Database (GAD): HS1BP3
Human Genome Epidemiology (HuGE) Navigator: HS1BP3 (1 document)

Export disorders for HS1BP3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for HS1BP3 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with HS1BP3)

Utopia: connect your pdf to the dynamic
world of online information

A variant in the HS1-BP3 gene is associated with fami lial essential tremor. (PubMed id 15699368)^{1, 3, 9} Higgins J.J....Rooney J.P. (2005)
DRD3 Ser9Gly and HS1BP3 Ala265Gly are not associated with Parkinson disease. (PubMed id 19524641)^{1, 4} Keeling B.H....Farrer M.J. (2009)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Isolation and characterization of a novel HS1 SH3 domain binding protein, HS1BP3. (PubMed id 10590261)^{1, 3} Takemoto Y....Hashimoto Y. (1999)
VCP phosphorylation-dependent interaction partners pre vent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)¹ Yu C.C....Chow L.P. (2013)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Human HS1BP3 induces cell apoptosis and activates AP- 1. (PubMed id 21699750)¹ Shi T....Ma D. (2011)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 64342	HGNC: 24979	AceView: FLJ14249	Ensembl:ENSG00000118960	euGenes: HUgn64342
ECgene: HS1BP3	H-InvDB: HS1BP3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HS1BP3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for HS1BP3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for HS1BP3 gene:
Search GeneIP for patents involving HS1BP3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Browse Recombinant/Natural Proteins
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	OriGene Antibodies for HS1BP3		OriGene RNAi products in human, mouse, rat for HS1BP3
	OriGene qPCR primer pairs and template standards for HS1BP3		OriGene Protein Over-expression Lysate for HS1BP3
	OriGene MassSpec something-or-other for HS1BP3		OriGene clones in human, mouse for HS1BP3
	OriGene qSTAR qPCR primer pairs in human, mouse for HS1BP3		OriGene Purified Protein for HS1BP3
	OriGene ORF clones in mouse, rat for HS1BP3		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for HS1BP3		OriGene Custom Protein Services for HS1BP3

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HS1BP3
	QIAGEN SeqTarget long-range PCR primers for resequencing HS1BP3
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HS1BP3
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HS1BP3
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HS1BP3
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HS1BP3

	GenScript Custom Purified and Recombinant Proteins Services for HS1BP3		GenScript cDNA clones with any tag delivered in your preferred vector for HS1BP3
	GenScript Custom Assay Services for HS1BP3		GenScript Custom Superior Antibodies Services for HS1BP3
	GenScript Custom overexpressing Cell Line Services for HS1BP3		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in HS1BP3 promoter
	Search Chromatin IP Primers for HS1BP3
	RT² qPCR Primer Assay in human, mouse, rat HS1BP3
	Search GNC Networks for HS1BP3
	SABiosciences Custom PCR Arrays for HS1BP3

Search Tocris compounds for HS1BP3 (H1BP3)

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	HS1BP3 antibodies
	HS1BP3 proteins
	HS1BP3 lysates

	Antibodies for HS1BP3
	See all of Abcam's Antibodies, Kits and Proteins for HS1BP3
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for HS1BP3
	Antibodies for HS1BP3
	ELISAs for HS1BP3
	CLIAs for HS1BP3

Search LifeMap BioReagents cell lines for HS1BP3

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HS1BP3

	SwitchGear 3'UTR luciferase reporter plasmids for HS1BP3
	SwitchGear Promoter luciferase reporter plasmids for HS1BP3

ThermoFisher Antibodies for HS1BP3

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HS1BP3

	inGenious Targeting Laboratory - Custom generated mouse model solutions for HS1BP3
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HS1BP3

Customized:

	lentivirus for stable overexpression of HS1BP3
	lentivirus expression plasmids for stable overexpression of HS1BP3
	adenovirus for overexpression of HS1BP3

LSBio Antibodies in human, mouse, rat for HS1BP3

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes HS1BP3 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

HS1BP3 Gene

HCLS1 Binding Protein 3

Aliases
for HS1BP3 gene

Summaries
for HS1BP3 gene

Genomic Views
for HS1BP3 gene

Proteins
for HS1BP3 gene

Protein Domains /
Families
for HS1BP3 gene

Function
for HS1BP3 gene

Pathways & Interactions
for HS1BP3 gene

Drugs & Compounds
for HS1BP3 gene

Transcripts
for HS1BP3 gene

Expression
for HS1BP3 gene

Orthologs
for HS1BP3 gene

Paralogs
for HS1BP3 gene

Genomic Variants
for HS1BP3 gene

Disorders / Diseases
for HS1BP3 gene

Publications
for HS1BP3 gene

External Searches for HS1BP3 gene

Genome Databases showing HS1BP3 gene

Other Databases showing HS1BP3 gene

Specialized Databases showing HS1BP3 gene

Intellectual Property
for HS1BP3 gene

Products
for HS1BP3 gene

View Random Gene

Advanced Search

Export list of displayed genes

HS1BP3 Gene

HCLS1 Binding Protein 3

Aliasesfor HS1BP3 gene

Summariesfor HS1BP3 gene

Genomic Viewsfor HS1BP3 gene

Proteinsfor HS1BP3 gene

Protein Domains /Familiesfor HS1BP3 gene

Functionfor HS1BP3 gene

Pathways & Interactionsfor HS1BP3 gene

Drugs & Compoundsfor HS1BP3 gene

Transcriptsfor HS1BP3 gene

Expression for HS1BP3 gene

Orthologsfor HS1BP3 gene

Paralogsfor HS1BP3 gene

Genomic Variantsfor HS1BP3 gene

Disorders / Diseasesfor HS1BP3 gene

Publicationsfor HS1BP3 gene

External Searches for HS1BP3 gene

Genome Databases showing HS1BP3 gene

Other Databases showing HS1BP3 gene

Specialized Databases showing HS1BP3 gene

Intellectual Propertyfor HS1BP3 gene

Productsfor HS1BP3 gene

View Random Gene

Aliases
for HS1BP3 gene

Summaries
for HS1BP3 gene

Genomic Views
for HS1BP3 gene

Proteins
for HS1BP3 gene

Protein Domains /
Families
for HS1BP3 gene

Function
for HS1BP3 gene

Pathways & Interactions
for HS1BP3 gene

Drugs & Compounds
for HS1BP3 gene

Transcripts
for HS1BP3 gene

Expression
for HS1BP3 gene

Orthologs
for HS1BP3 gene

Paralogs
for HS1BP3 gene

Genomic Variants
for HS1BP3 gene

Disorders / Diseases
for HS1BP3 gene

Publications
for HS1BP3 gene

Intellectual Property
for HS1BP3 gene

Products
for HS1BP3 gene