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Aliases for HRSP12 Gene

Aliases for HRSP12 Gene

  • Heat-Responsive Protein 12 2 3 4
  • 14.5 KDa Translational Inhibitor Protein 3 4
  • Translational Inhibitor P14.5 2 3
  • UK114 Antigen Homolog 3 4
  • P14.5 3 4
  • PSP 3 4
  • Translational Inhibitor Protein P14.5 3
  • Perchloric Acid-Soluble Protein 3
  • EC 3.1.-.- 4
  • UK114 3

External Ids for HRSP12 Gene

Previous GeneCards Identifiers for HRSP12 Gene

  • GC08M099072
  • GC08M099183
  • GC08M094318
  • GC08M099114

Summaries for HRSP12 Gene

GeneCards Summary for HRSP12 Gene

HRSP12 (Heat-Responsive Protein 12) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and deaminase activity.

UniProtKB/Swiss-Prot for HRSP12 Gene

  • Endoribonuclease responsible for the inhibition of the translation by cleaving mRNA. Inhibits cell-free protein synthesis. Cleaves phosphodiester bonds only in single-stranded RNA (By similarity).

Gene Wiki entry for HRSP12 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HRSP12 Gene

Genomics for HRSP12 Gene

Regulatory Elements for HRSP12 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HRSP12 Gene

Chromosome:
8
Start:
98,102,339 bp from pter
End:
98,117,241 bp from pter
Size:
14,903 bases
Orientation:
Minus strand

Genomic View for HRSP12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HRSP12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HRSP12 Gene

Proteins for HRSP12 Gene

  • Protein details for HRSP12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52758-UK114_HUMAN
    Recommended name:
    Ribonuclease UK114
    Protein Accession:
    P52758
    Secondary Accessions:
    • Q6FHU9
    • Q6IBG0

    Protein attributes for HRSP12 Gene

    Size:
    137 amino acids
    Molecular mass:
    14494 Da
    Quaternary structure:
    • Homotrimer.

    Three dimensional structures from OCA and Proteopedia for HRSP12 Gene

neXtProt entry for HRSP12 Gene

Proteomics data for HRSP12 Gene at MOPED

Post-translational modifications for HRSP12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HRSP12 Gene

No data available for DME Specific Peptides for HRSP12 Gene

Domains & Families for HRSP12 Gene

Suggested Antigen Peptide Sequences for HRSP12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52758

UniProtKB/Swiss-Prot:

UK114_HUMAN :
  • Belongs to the RutC family.
Family:
  • Belongs to the RutC family.
genes like me logo Genes that share domains with HRSP12: view

No data available for Gene Families for HRSP12 Gene

Function for HRSP12 Gene

Molecular function for HRSP12 Gene

UniProtKB/Swiss-Prot Function:
Endoribonuclease responsible for the inhibition of the translation by cleaving mRNA. Inhibits cell-free protein synthesis. Cleaves phosphodiester bonds only in single-stranded RNA (By similarity).

Enzyme Numbers (IUBMB) for HRSP12 Gene

Gene Ontology (GO) - Molecular Function for HRSP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016892 endoribonuclease activity, producing 3-phosphomonoesters IEA --
GO:0019239 deaminase activity IEA --
GO:0036041 long-chain fatty acid binding IEA --
GO:0042803 protein homodimerization activity IEA --
GO:0043167 ion binding --
genes like me logo Genes that share ontologies with HRSP12: view

Phenotypes for HRSP12 Gene

genes like me logo Genes that share phenotypes with HRSP12: view

Animal Model Products

miRNA for HRSP12 Gene

miRTarBase miRNAs that target HRSP12

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HRSP12

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for HRSP12 Gene

Localization for HRSP12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HRSP12 Gene

Cytoplasm. Nucleus. Note=Mostly cytoplasmic but, in less differentiated cells occasionally nuclear.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HRSP12 Gene COMPARTMENTS Subcellular localization image for HRSP12 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 2
mitochondrion 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for HRSP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm TAS 8530410
GO:0005739 mitochondrion IEA --
GO:0005777 peroxisome IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with HRSP12: view

Pathways & Interactions for HRSP12 Gene

SuperPathways for HRSP12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HRSP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development IEA --
GO:0006449 regulation of translational termination TAS 8530410
GO:0007420 brain development IEA --
GO:0008152 metabolic process --
GO:0017148 negative regulation of translation IEA --
genes like me logo Genes that share ontologies with HRSP12: view

No data available for Pathways by source and SIGNOR curated interactions for HRSP12 Gene

Drugs & Compounds for HRSP12 Gene

(1) Drugs for HRSP12 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Benzoic Acid Experimental Pharma Target 7

(2) Additional Compounds for HRSP12 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fatty acid
perchloric acid
genes like me logo Genes that share compounds with HRSP12: view

Transcripts for HRSP12 Gene

Unigene Clusters for HRSP12 Gene

Heat-responsive protein 12:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HRSP12

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HRSP12 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - -
SP2: - - -
SP3: - - - -
SP4:
SP5: -

Relevant External Links for HRSP12 Gene

GeneLoc Exon Structure for
HRSP12
ECgene alternative splicing isoforms for
HRSP12

Expression for HRSP12 Gene

mRNA expression in normal human tissues for HRSP12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HRSP12 Gene

This gene is overexpressed in Liver (x15.2) and Kidney - Cortex (x4.4).

Protein differential expression in normal tissues from HIPED for HRSP12 Gene

This gene is overexpressed in Liver, secretome (39.7) and Liver (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HRSP12 Gene



SOURCE GeneReport for Unigene cluster for HRSP12 Gene Hs.18426

mRNA Expression by UniProt/SwissProt for HRSP12 Gene

P52758-UK114_HUMAN
Tissue specificity: Hepatocytes and renal distal tubular epithelial cells. Only weak expression in other tissues
genes like me logo Genes that share expression patterns with HRSP12: view

Protein tissue co-expression partners for HRSP12 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for HRSP12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HRSP12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HRSP12 35
  • 87.35 (n)
  • 86.13 (a)
HRSP12 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HRSP12 35
  • 90.27 (n)
  • 91.97 (a)
-- 36
  • 92 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Hrsp12 35
  • 84.94 (n)
  • 81.48 (a)
Hrsp12 16
Hrsp12 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HRSP12 35
  • 99.51 (n)
  • 99.27 (a)
HRSP12 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hrsp12 35
  • 84.67 (n)
  • 86.86 (a)
oppossum
(Monodelphis domestica)
Mammalia HRSP12 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HRSP12 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves HRSP12 35
  • 72.47 (n)
  • 72.73 (a)
HRSP12 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HRSP12 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hrp12 35
  • 70.1 (n)
  • 77.21 (a)
Str.2950 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.8312 35
zebrafish
(Danio rerio)
Actinopterygii Dr.18514 35
hrsp12 35
  • 70.12 (n)
  • 72.59 (a)
hrsp12 36
  • 72 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12324 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005327 35
  • 52.7 (n)
  • 49.26 (a)
fruit fly
(Drosophila melanogaster)
Insecta UK114 35
  • 52.07 (n)
  • 46.72 (a)
UK114 36
  • 42 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_C23G10.2 35
  • 64.32 (n)
  • 65.62 (a)
C23G10.2 36
  • 49 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HMF1 35
  • 51.3 (n)
  • 41.74 (a)
HMF1 36
  • 37 (a)
OneToMany
MMF1 36
  • 31 (a)
OneToMany
MMF1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G20390 35
  • 57.67 (n)
  • 54.76 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7313 35
rice
(Oryza sativa)
Liliopsida Os07g0516200 35
  • 57.1 (n)
  • 52.46 (a)
Species with no ortholog for HRSP12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HRSP12 Gene

ENSEMBL:
Gene Tree for HRSP12 (if available)
TreeFam:
Gene Tree for HRSP12 (if available)

Paralogs for HRSP12 Gene

Pseudogenes.org Pseudogenes for HRSP12 Gene

genes like me logo Genes that share paralogs with HRSP12: view

No data available for Paralogs for HRSP12 Gene

Variants for HRSP12 Gene

Sequence variations from dbSNP and Humsavar for HRSP12 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs8218 -- 98,102,742(-) GACAG(G/T)GTGAG utr-variant-3-prime
rs1026653 -- 98,105,304(-) CTGAA(A/G)AAATT intron-variant
rs1462977 -- 98,103,131(-) TCTAA(C/T)AGGGC intron-variant
rs1955217 -- 98,114,710(-) tcttc(C/T)caatg intron-variant
rs1955218 -- 98,114,509(-) AAAAT(A/C)CCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HRSP12 Gene

Variant ID Type Subtype PubMed ID
nsv465745 CNV Gain 19166990
nsv465746 CNV Gain 19166990
nsv831405 CNV Gain 17160897
nsv465747 CNV Gain 19166990

Variation tolerance for HRSP12 Gene

Residual Variation Intolerance Score: 41.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HRSP12 Gene

HapMap Linkage Disequilibrium report
HRSP12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HRSP12 Gene

Disorders for HRSP12 Gene

Relevant External Links for HRSP12

Genetic Association Database (GAD)
HRSP12
Human Genome Epidemiology (HuGE) Navigator
HRSP12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HRSP12
genes like me logo Genes that share disorders with HRSP12: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HRSP12 Gene

Publications for HRSP12 Gene

  1. A bidirectional promoter connects the p14.5 gene to the gene for RNase P and RNase MRP protein subunit hPOP1. (PMID: 9405234) Schmiedeknecht G. … Schmitz G. (Biochem. Biophys. Res. Commun. 1997) 2 23 67
  2. Isolation and characterization of a 14.5-kDa trichloroacetic-acid- soluble translational inhibitor protein from human monocytes that is upregulated upon cellular differentiation. (PMID: 8973653) Schmiedeknecht G. … Schmitz G. (Eur. J. Biochem. 1996) 2 23 67
  3. Members of the YjgF/YER057c/UK114 family of proteins inhibit phosphoribosylamine synthesis in vitro. (PMID: 20817725) Lambrecht J.A. … Downs D.M. (J. Biol. Chem. 2010) 2 67
  4. Simultaneous determination of acyclovir, ganciclovir, and (R)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine in human plasma using high-performance liquid chromatography. (PMID: 19358150) Weller D.R. … Vezina H.E. (Biomed. Chromatogr. 2009) 23 67
  5. Motility and protein phosphorylation in healthy and asthenozoospermic sperm. (PMID: 19678645) Chan C.C. … Wu G.J. (J. Proteome Res. 2009) 23 67

Products for HRSP12 Gene

Sources for HRSP12 Gene

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