HRNR Gene
protein-coding GIFtS: 44
GCID: GC01M152184
|
|
hornerin
| |
Aliases
for HRNR gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Hornerin1 | | Filaggrin Family Member 32 | | FLG31 2 | | Intermediate Filament-Associated Protein2 | | S100A161 2 | | S100A183 | | S100a181 2 | | |
Export aliases for HRNR gene to outside databasesPrevious GC identifers: GC01M148998 GC01M150451 GC01M123561 |
Summaries
for HRNR gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: HORN_HUMAN, Q86YZ3Function: May play a role in cornification
|
Genomic Views
for HRNR gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_018912.1 NC_000001.10 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HRNR gene promoter:
Pax-2b Brachyury FOXJ2 (long isoform) Pax-2 STAT5A Pax-2a FOXJ2 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for HRNR
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HRNR |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21.3 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21.3HRNR Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M152184: view genomic region
(about GC identifiers)
Start:
|
152,184,558 bp from pter |
End:
|
152,196,669 bp from pter |
Size:
|
12,112 bases |
Orientation:
|
minus strand |
|
Proteins
for HRNR gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HORN_HUMAN, Q86YZ3 (See
protein sequence)Recommended Name: Hornerin Size: 2850 amino acids; 282390 Da
Subcellular location: Cytoplasmic granule (By similarity). Note=Found in keratohyalin granules in the granular cells ofthe epidermis (By similarity)
Secondary accessions: Q5U1F4Explore the universe of human proteins at neXtProt for HRNR: NX_Q86YZ3
Post-translational modifications:
Processed during the process of epidermal differentiation (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86YZ3
HRNR Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001009931.1
ENSEMBL proteins: ENSP00000357791
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001533 | cornified envelope |
IEA | -- | | GO:0070062 | extracellular vesicular exosome |
IDA | -- |
HRNR for ontologies About GeneDecksing
HRNR Antibody Products:
Assay Products for HRNR: |
Protein
Domains /
Families
for HRNR gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HRNR for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q86YZ3ProtoNet protein and cluster: Q86YZ3 1 Blocks protein family: IPB001751 Calcium-binding protein
UniProtKB/Swiss-Prot: HORN_HUMAN, Q86YZ3Similarity: Belongs to the S100-fused protein familySimilarity: In the N-terminal section; belongs to the S-100 familySimilarity: Contains 2 EF-hand domains |
Function
for HRNR gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: HORN_HUMAN, Q86YZ3Function: May play a role in cornification
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HRNR (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HRNR
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for HRNR | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HRNR |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRNR |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004640 | phosphoribosylanthranilate isomerase activity |
IEA | -- | | GO:0005509 | calcium ion binding |
IEA | -- | | GO:0017111 | nucleoside-triphosphatase activity |
IEA | -- |
HRNR for ontologies About GeneDecksing
|
Pathways & Interactions
for HRNR gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HRNR
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/79 Interacting proteins for HRNR (Q86YZ32, 3 ENSP000003577914) via UniProtKB, MINT, STRING, and/or I2D (see all 79)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006568 | tryptophan metabolic process |
IEA | -- | | GO:0009143 | nucleoside triphosphate catabolic process |
IEA | -- | | GO:0031424 | keratinization |
IEA | -- |
HRNR for ontologies About GeneDecksing
|
Drugs & Compounds
for HRNR gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HRNR
Search CenterWatch for drugs/clinical trials and news about HRNR / HORN
|
Transcripts
for HRNR gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HRNR gene: NM_001009931.2 Unigene Cluster for HRNR: Hornerin Hs.490162 [show with all ESTs]Unigene Representative Sequence: AY3967411 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000368801(uc001ezt.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HRNR (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HRNR
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HRNR (NM_001009931) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HRNR | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HRNR |
Additional cDNA sequence: AB104446.1 AB180729.1 AY396741.1 1 DOTS entry: DT.100696948 1 AceView cDNA sequence: AB104446
GeneLoc Exon Structure
|
Expression
for HRNR gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HRNR expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAATACAAT
About this image
See HRNR Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.490162
UniProtKB/Swiss-Prot: HORN_HUMAN, Q86YZ3Tissue specificity: Expressed in psoriatic and regenerating skin after wounding
SABiosciences Custom PCR Arrays for HRNR
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HRNR
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HRNR | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HRNR | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HRNR | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRNR |
Orthologs
for HRNR gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for HRNR gene from 1/3 species (see all 3) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
TCHHL16 |
-- |
15(a) |
1 → many |
GL343369.1(7-2795) |
ENSEMBL Gene Tree for HRNR (if available)
TreeFam Gene Tree for HRNR (if available) |
Paralogs
for HRNR gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HRNR gene
- FLG22 RPTN2 FLG2 CRNN2 TCHHL12
15 SIMAP similar genes for HRNR using alignment to 2 protein entries: HORN_HUMAN (see all proteins):FLG S100A9 S100B S100A12 S100A2 S100G
S100Z S100A16 S100A11 S100A6 S100A13 S100A8
S100A5 S100A10 FLG2
HRNR for paralogs About GeneDecksing
|
Genomic Variants
for HRNR gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HRNR (152184558 - 152196669 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 13 variations for HRNR
13 CNVs: 84572 70031 43740 74712 34710 31660 70030 23340 74711 30437 84571 34709 0392 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HRNR |
|
Disorders
/ Diseases
for HRNR gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HRNR for disorders About GeneDecksing
4  diseases for HRNR: About MalaCardsirritant dermatitis atopic dermatitis dermatitis eczema
Human Genome Epidemiology (HuGE) Navigator: HRNR (1 document)
Export disorders for HRNR gene to outside databases
|
Publications
for HRNR gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HRNR gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with HRNR) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of human hornerin and its expression in regenerating and psoriatic skin. (PubMed id 15507446)1, 2, 9 Takaishi M.... Huh N.-H. (2005)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Highly complex peptide aggregates of the S100 fused-type protein hornerin are present in human skin. (PubMed id 19020553)1, 9 Wu Z....SchrAPder J.M. (2009)
- Hornerin, an S100 family protein, is functional in bre ast cells and aberrantly expressed in breast cancer. (PubMed id 22727333)1 Fleming J.M....Vonderhaar B.K. (2012)
- Proteomic identification of common SCF ubiquitin ligas e FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (2012)
- An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Hornerin is a component of the epidermal cornified ce ll envelopes. (PubMed id 21282207)1 Henry J....Simon M. (2011)
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for HRNR gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HRNR gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HRNR gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HRNR gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HRNR | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HRNR gene:
Search GeneIP for patents involving HRNR
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HRNR gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HRNR | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HRNR | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HRNR | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HRNR | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HRNR | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HRNR | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HRNR | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HRNR | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HRNR | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HRNR | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HRNR | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HRNR |
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| | | | Search Tocris compounds for HRNR |
| |  |  |  |  | | | | |
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 | | | HRNR Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRNR |
|  |  |  | | | | Search ThermoFisher Antibodies for HRNR |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HRNR |
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