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HRNR Gene

protein-coding   GIFtS: 45
GCID: GC01M152184

Hornerin

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
hornerin1 2     S100a182
Filaggrin Family Member 31 2     Intermediate Filament-Associated Protein2
FLG32     S100A183
S100A162     

External Ids:    HGNC: 208461   Entrez Gene: 3886972   Ensembl: ENSG000001979157   UniProtKB: Q86YZ33   

Export aliases for HRNR gene to outside databases

Previous GC identifers: GC01M148998 GC01M150451 GC01M123561


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HRNR Gene:
HRNR (hornerin) is a protein-coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is RPTN.

UniProtKB/Swiss-Prot: HORN_HUMAN, Q86YZ3
Function: May play a role in cornification




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HRNR gene promoter:
         Pax-2b   Brachyury   FOXJ2 (long isoform)   Pax-2   STAT5A   Pax-2a   FOXJ2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHRNR promoter sequence
   Search Chromatin IP Primers for HRNR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HRNR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.3

HRNR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HRNR gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M152184:  view genomic region     (about GC identifiers)

Start:
152,184,558 bp from pter      End:
152,196,669 bp from pter
Size:
12,112 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HORN_HUMAN, Q86YZ3 (See protein sequence)
Recommended Name: Hornerin  
Size: 2850 amino acids; 282390 Da
Secondary accessions: Q5U1F4

Explore the universe of human proteins at neXtProt for HRNR: NX_Q86YZ3

Explore proteomics data for HRNR at MOPED

Post-translational modifications: 

  • Processed during the process of epidermal differentiation (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HRNR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001009931.1  
    ENSEMBL proteins: 
     ENSP00000357791  

    HRNR Human Recombinant Protein Products:

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    antibodies-online peptides for HRNR

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    antibodies-online antibodies for HRNR (23 products) 

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    antibodies-online kits for HRNR (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    5 InterPro protein domains:
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR013787 S100_Ca-bd_sub
     IPR018247 EF_Hand_1_Ca_BS
     IPR001751 S100/CaBP-9k_CS

    Graphical View of Domain Structure for InterPro Entry Q86YZ3

    ProtoNet protein and cluster: Q86YZ3

    1 Blocks protein domain: IPB001751 Calcium-binding protein

    UniProtKB/Swiss-Prot: HORN_HUMAN, Q86YZ3
    Similarity: Belongs to the S100-fused protein family
    Similarity: In the N-terminal section; belongs to the S-100 family
    Similarity: Contains 2 EF-hand domains


    Find genes that share domains with HRNR           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HORN_HUMAN, Q86YZ3
    Function: May play a role in cornification

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
         
    Find genes that share ontologies with HRNR           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HRNR

    miRNA
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    miRTarBase miRNAs that target HRNR:
    hsa-mir-1 (MIRT024074), hsa-mir-193b-3p (MIRT016530)

    Block miRNA regulation of human, mouse, rat HRNR using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate HRNR:
    hsa-miR-2052 hsa-miR-3161 hsa-miR-433 hsa-miR-7-1* hsa-miR-7-2* hsa-miR-3145-3p
    SwitchGear 3'UTR luciferase reporter plasmidHRNR 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HRNR

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HORN_HUMAN, Q86YZ3: Cytoplasmic granule (By similarity). Note=Found in keratohyalin granules in the granular
    cells of the epidermis (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol3
    cytoskeleton2
    nucleus2
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001533cornified envelope IEA--
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with HRNR           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HRNR
    Interactions:

        Search GeneGlobe Interaction Network for HRNR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for HRNR (Q86YZ32, 3 ENSP000003577914) via UniProtKB, MINT, STRING, and/or I2D (see all 78)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631042, 3, ENSP000003095034MINT-3318772 MINT-3318788 I2D: score=1 STRING: ENSP00000309503
    BTKQ061873, ENSP000003081764I2D: score=1 STRING: ENSP00000308176
    KHDRBS2Q5VWX13, ENSP000002811564I2D: score=1 STRING: ENSP00000281156
    RAD51CO435023, ENSP000003367014I2D: score=1 STRING: ENSP00000336701
    OTUD4Q018043, ENSP000004092794I2D: score=1 STRING: ENSP00000409279
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031424keratinization IEA--
    GO:0061436establishment of skin barrier IEP--

    Find genes that share ontologies with HRNR           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HRNR (HORN)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HRNR gene: 
    NM_001009931.2  

    Unigene Cluster for HRNR:

    Hornerin
    Hs.490162  [show with all ESTs]
    Unigene Representative Sequence: NM_001009931
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000368801(uc001ezt.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat HRNR using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate HRNR:
    hsa-miR-2052 hsa-miR-3161 hsa-miR-433 hsa-miR-7-1* hsa-miR-7-2* hsa-miR-3145-3p
    SwitchGear 3'UTR luciferase reporter plasmidHRNR 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HRNR
    Predesigned siRNA for gene silencing in human, mouse, rat HRNR
    Clone
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    OriGene clones in human, mouse for HRNR (see all 4)
    OriGene ORF clones in mouse, rat for HRNR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HRNR (NM_001009931)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HRNR
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HRNR
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for HRNR
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HRNR
      QuantiTect SYBR Green Assays in human, mouse, rat HRNR
      QuantiFast Probe-based Assays in human, mouse, rat HRNR

    Additional mRNA sequence: 

    AB104446.1 AB180729.1 AY396741.1 

    1 DOTS entry:

    DT.100696948 

    1 AceView cDNA sequence:

    AB104446 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HRNR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAATACAAT
    HRNR Expression
    About this image

    HRNR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HRNR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.490162

    UniProtKB/Swiss-Prot: HORN_HUMAN, Q86YZ3
    Tissue specificity: Expressed in psoriatic and regenerating skin after wounding

        Custom PCR Arrays for HRNR
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRNR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HRNR gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hrnr5 hornerin   --   3 (40.39 cM) 93319749 
    chicken
    (Gallus gallus)
    Aves CRNN6
    Gallus gallus cornulin (CRNN), mRNA.
    14(a)
    1 → many
    25(1132880-1134156)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    13(a)
    1 → many
    GL343369.1(7-2795)


    ENSEMBL Gene Tree for HRNR (if available)
    TreeFam Gene Tree for HRNR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HRNR gene
    RPTN2  FLG22  TCHH2  CRNN2  FLG2  TCHHL12  
    15 SIMAP similar genes for HRNR using alignment to 2 protein entries:     HORN_HUMAN (see all proteins):
    FLG    S100A9    S100B    S100A12    S100A2    S100G
    S100Z    S100A16    S100A11    S100A6    S100A13    S100A8
    S100A5    S100A10    FLG2

    Find genes that share paralogs with HRNR           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HRNR (see all 890)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2021758271,2
    C,Funtested1158689354(+) TGTTGG/ACCACA 2 /D syn11Minor allele frequency- A:0.03EU 1253
    rs1392256751,2
    C,Funtested1158692927(+) GAGAAG/ATGACC 2 /H syn11Minor allele frequency- A:0.00NA 4548
    rs412661121,2
    C,F--152185762(+) GAAGAG/CTGCCC 2 /H /Q mis19Minor allele frequency- C:0.27NA CSA WA EA EU 5862
    rs412661141,2
    C,F--152185768(+) TGCCCT/GGAACC 2 /S syn14Minor allele frequency- G:0.08NA WA 124
    rs618149321,2
    F--152185774(+) GAACCG/AGACCC 2 /S syn12Minor allele frequency- A:0.00NA 4
    rs412661161,2
    C,F--152185780(+) GACCCA/GTGTCG 2 H syn13Minor allele frequency- G:0.33NA 6
    rs761023811,2
    C--152185790(+) GGCCGC/TGGCTA 2 H R mis12Minor allele frequency- T:0.00NA 4
    rs412661181,2
    C,F--152185796(+) GGCTAG/AGAGAC 2 /P /L mis13Minor allele frequency- A:0.33NA 6
    rs799366361,2
    C--152185815(+) TCCAGC/ACCCAT 2 /A /S mis11Minor allele frequency- A:0.50NA 2
    rs789801751,2
    C--152185819(+) GCCCCC/ATGTCG 2 /Q /H mis11Minor allele frequency- A:0.00NA 2

    HapMap Linkage Disequilibrium report for HRNR (152184558 - 152196669 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HRNR (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1763423CNV Deletion17803354
    esv2665574CNV Deletion23128226
    esv2159882CNV Deletion18987734
    esv2718106CNV Deletion23290073
    nsv471347CNV Duplication19718026
    nsv2877CNV Insertion18451855
    nsv57CNV Insertion15895083
    nsv509468CNV Insertion20534489
    nsv872442CNV Gain21882294
    dgv74n67CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HRNR
    DNA2.0 Custom Variant and Variant Library Synthesis for HRNR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with HRNR           About GenesLikeMe

    Genetic Association Database (GAD): HRNR
    Human Genome Epidemiology (HuGE) Navigator: HRNR (1 document)

    Export disorders for HRNR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HRNR gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with HRNR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of human hornerin and its expression in regenerating and psoriatic skin. (PubMed id 15507446)1, 2, 9 Takaishi M.... Huh N.-H. (J. Biol. Chem. 2005)
    2. Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients. (PubMed id 19601998)1, 4 Stemmler S....Hoffjan S. (Int. J. Immunogenet. 2009)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. Highly complex peptide aggregates of the S100 fused-type protein hornerin are present in human skin. (PubMed id 19020553)1, 9 Wu Z....SchrAPder J.M. (J. Invest. Dermatol. 2009)
    5. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (EMBO J. 2013)
    6. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    7. Association of the chromosome 11q13.5 variant with atopic dermatitis in Austrian patients. (PubMed id 23557745)1 Greisenegger E.K....Kopp T. (Eur J Dermatol 2013)
    8. Hornerin, an S100 family protein, is functional in breast cells and aberrantly expressed in breast cancer. (PubMed id 22727333)1 Fleming J.M....Vonderhaar B.K. (BMC Cancer 2012)
    9. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)
    10. Highly efficient purification of protein complexes from mammalian cells using a novel streptavidin-binding peptide and hexahistidine tandem tag system: application to Bruton's tyrosine kinase. (PubMed id 21080425)1 Li Y....Vondriska T.M. (Protein Sci. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 388697 HGNC: 20846 AceView: LOC388697 Ensembl:ENSG00000197915 euGenes: HUgn388697
    ECgene: HRNR H-InvDB: HRNR

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HRNR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HRNR gene:
    Search GeneIP for patents involving HRNR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for HRNR  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for HRNR  
     OriGene qSTAR qPCR primer pairs in human, mouse for HRNR   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for HRNR   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HRNR   OriGene Custom Protein Services for HRNR  

     
     
     Block miRNA regulation of human, mouse, rat HRNR using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HRNR
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HRNR Predesigned siRNA for gene silencing in human, mouse, rat HRNR
     QuantiFast Probe-based Assays in human, mouse, rat HRNR QuantiTect SYBR Green Assays in human, mouse, rat HRNR
     Custom PCR Arrays for HRNR Search Chromatin IP Primers for HRNR
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HRNR  Search GeneGlobe Interaction Network for HRNR
     Regulatory tfbs in HRNR promoter
     GenScript Custom Purified and Recombinant Proteins Services for HRNR GenScript cDNA clones with any tag delivered in your preferred vector for HRNR
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     Search Tocris compounds for HRNR (HORN)
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     Novus Tissue Slides
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     Browse ESI BIO Cell Lines and PureStem Progenitors for HRNR
     Gene Synthesis
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRNR
     SwitchGear 3'UTR luciferase reporter plasmids for HRNR
     SwitchGear Promoter luciferase reporter plasmids for HRNR
     Search ThermoFisher Antibodies for HRNR
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HRNR
     Browse compounds at ApexBio
     Search Addgene for plasmids for HRNR
      Search eBioscience for proteins for HRNR
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      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for HRNR
     antibodies-online antibodies for HRNR (23 products)
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     antibodies-online proteins for HRNR
           
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