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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HRNR Gene

protein-coding   GIFtS: 44
GCID: GC01M152184

Hornerin

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
hornerin1 2     S100a182
Filaggrin Family Member 31 2     Intermediate Filament-Associated Protein2
FLG32     S100A183
S100A162     

External Ids:    HGNC: 208461   Entrez Gene: 3886972   Ensembl: ENSG000001979157   UniProtKB: Q86YZ33   

Export aliases for HRNR gene to outside databases

Previous GC identifers: GC01M148998 GC01M150451 GC01M123561


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for HRNR Gene: 
HRNR (hornerin) is a protein-coding gene. Diseases associated with HRNR include irritant dermatitis, and eczema. GO annotations related to this gene include phosphoribosylanthranilate isomerase activity and calcium ion binding. An important paralog of this gene is RPTN.

UniProtKB/Swiss-Prot: HORN_HUMAN, Q86YZ3
Function: May play a role in cornification




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HRNR gene promoter:
         Pax-2b   Brachyury   FOXJ2 (long isoform)   Pax-2   STAT5A   Pax-2a   FOXJ2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHRNR promoter sequence
   Search SABiosciences Chromatin IP Primers for HRNR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HRNR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.3

HRNR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HRNR gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M152184:  view genomic region     (about GC identifiers)

Start:
152,184,558 bp from pter      End:
152,196,669 bp from pter
Size:
12,112 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HORN_HUMAN, Q86YZ3 (See protein sequence)
Recommended Name: Hornerin  
Size: 2850 amino acids; 282390 Da
Subcellular location: Cytoplasmic granule (By similarity). Note=Found in keratohyalin granules in the granular
cells of the epidermis (By similarity)
Secondary accessions: Q5U1F4

Explore the universe of human proteins at neXtProt for HRNR: NX_Q86YZ3

Explore proteomics data for HRNR at MOPED 

Post-translational modifications:

  • UniProtKB: Processed during the process of epidermal differentiation (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86YZ3

  • HRNR Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HRNR Protein Expression
    REFSEQ proteins: NP_001009931.1  
    ENSEMBL proteins: 
     ENSP00000357791  

    Human Recombinant Protein Products for HRNR: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HRNR 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0070062extracellular vesicular exosome IDA--

    HRNR for ontologies           About GeneDecksing



    HRNR Antibody Products: 
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    Assay Products for HRNR: 
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    Cloud-Clone Corp. CLIAs for HRNR


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    EFHAND: EF-hand domain containing

    5 InterPro protein domains:
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom
     IPR013787 S100_Ca-bd_sub
     IPR018247 EF_Hand_1_Ca_BS
     IPR001751 S100/CaBP-9k_CS

    Graphical View of Domain Structure for InterPro Entry Q86YZ3

    ProtoNet protein and cluster: Q86YZ3

    1 Blocks protein domain: IPB001751 Calcium-binding protein

    UniProtKB/Swiss-Prot: HORN_HUMAN, Q86YZ3
    Similarity: Belongs to the S100-fused protein family
    Similarity: In the N-terminal section; belongs to the S-100 family
    Similarity: Contains 2 EF-hand domains


    HRNR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HORN_HUMAN, Q86YZ3
    Function: May play a role in cornification

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
         
    HRNR for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HRNR 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HRNR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HRNR 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HRNR 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HRNR
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate HRNR:
    hsa-miR-2052 hsa-miR-3161 hsa-miR-433 hsa-miR-7-1* hsa-miR-7-2* hsa-miR-3145-3p
    SwitchGear 3'UTR luciferase reporter plasmidHRNR 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HRNR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HRNR

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for HRNR


    Clone
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    OriGene clones in human, mouse for HRNR (see all 4)
    OriGene ORF clones in mouse, rat for HRNR
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    GenScript: all cDNA clones in your preferred vector: HRNR (NM_001009931)
    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRNR


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HRNR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/79 Interacting proteins for HRNR (Q86YZ32, 3 ENSP000003577914) via UniProtKB, MINT, STRING, and/or I2D (see all 79)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631042, 3, ENSP000003095034MINT-3318772 MINT-3318788 I2D: score=1 STRING: ENSP00000309503
    BTKQ061873, ENSP000003081764I2D: score=1 STRING: ENSP00000308176
    KHDRBS2Q5VWX13, ENSP000002811564I2D: score=1 STRING: ENSP00000281156
    RAD51CO435023, ENSP000003367014I2D: score=1 STRING: ENSP00000336701
    OTUD4Q018043, ENSP000004092794I2D: score=1 STRING: ENSP00000409279
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031424keratinization IEA--

    HRNR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HRNR (HORN)

    Search CenterWatch for drugs/clinical trials and news about HRNR / HORN

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HRNR gene: 
    NM_001009931.2  

    Unigene Cluster for HRNR:

    Hornerin
    Hs.490162  [show with all ESTs]
    Unigene Representative Sequence: NM_001009931
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000368801(uc001ezt.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HRNR
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate HRNR:
    hsa-miR-2052 hsa-miR-3161 hsa-miR-433 hsa-miR-7-1* hsa-miR-7-2* hsa-miR-3145-3p
    SwitchGear 3'UTR luciferase reporter plasmidHRNR 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HRNR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HRNR
    Clone
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    OriGene clones in human, mouse for HRNR (see all 4)
    OriGene ORF clones in mouse, rat for HRNR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HRNR (NM_001009931)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HRNR
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HRNR
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for HRNR
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HRNR
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HRNR
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HRNR

    Additional mRNA sequence: 

    AB104446.1 AB180729.1 AY396741.1 

    1 DOTS entry:

    DT.100696948 

    1 AceView cDNA sequence:

    AB104446 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HRNR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAATACAAT
    HRNR Expression
    About this image


    See HRNR Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.490162

    UniProtKB/Swiss-Prot: HORN_HUMAN, Q86YZ3
    Tissue specificity: Expressed in psoriatic and regenerating skin after wounding

        SABiosciences Custom PCR Arrays for HRNR
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for HRNR
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HRNR
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HRNR
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HRNR
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRNR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for HRNR gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hrnr1 , 5 hornerin1, 5 59.49(n)1
    51.74(a)1
      3 (40.39 cM)5
    687231  NM_133698.21  NP_598459.21 
     933197495 
    chicken
    (Gallus gallus)
    Aves CRNN6
    cornulin
    11(a)
    1 → many
    25(1132880-1134156)
    lizard
    (Anolis carolinensis)
    Reptilia TCHHL16
    Uncharacterized protein
    12(a)
    1 → many
    GL343369.1(7-2795)


    ENSEMBL Gene Tree for HRNR (if available)
    TreeFam Gene Tree for HRNR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HRNR gene
    RPTN2  FLG22  TCHH2  CRNN2  FLG2  TCHHL12  
    15 SIMAP similar genes for HRNR using alignment to 2 protein entries:     HORN_HUMAN (see all proteins):
    FLG    S100A9    S100B    S100A12    S100A2    S100G
    S100Z    S100A16    S100A11    S100A6    S100A13    S100A8
    S100A5    S100A10    FLG2

    HRNR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/890 SNPs in HRNR are shown (see all 890)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2021758271,2
    C,Funtested1158689354(+) TGTTGG/ACCACA 2 /D syn11Minor allele frequency- A:0.03EU 1253
    rs1392256751,2
    C,Funtested1158692927(+) GAGAAG/ATGACC 2 /H syn11Minor allele frequency- A:0.00NA 4548
    rs412661121,2
    C,F--152185762(+) GAAGAG/CTGCCC 2 /H /Q mis19Minor allele frequency- C:0.27NA CSA WA EA EU 5862
    rs412661141,2
    C,F--152185768(+) TGCCCT/GGAACC 2 /S syn14Minor allele frequency- G:0.08NA WA 124
    rs618149321,2
    F--152185774(+) GAACCG/AGACCC 2 /S syn12Minor allele frequency- A:0.00NA 4
    rs412661161,2
    C,F--152185780(+) GACCCA/GTGTCG 2 H syn13Minor allele frequency- G:0.33NA 6
    rs761023811,2
    C--152185790(+) GGCCGC/TGGCTA 2 H R mis12Minor allele frequency- T:0.00NA 4
    rs412661181,2
    C,F--152185796(+) GGCTAG/AGAGAC 2 /P /L mis13Minor allele frequency- A:0.33NA 6
    rs799366361,2
    C--152185815(+) TCCAGC/ACCCAT 2 /A /S mis11Minor allele frequency- A:0.50NA 2
    rs789801751,2
    C--152185819(+) GCCCCC/ATGTCG 2 /Q /H mis11Minor allele frequency- A:0.00NA 2

    HapMap Linkage Disequilibrium report for HRNR (152184558 - 152196669 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for HRNR (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1763423CNV Deletion17803354
    esv2665574CNV Deletion23128226
    esv2159882CNV Deletion18987734
    esv2718106CNV Deletion23290073
    nsv471347CNV Duplication19718026
    nsv2877CNV Insertion18451855
    nsv57CNV Insertion15895083
    nsv509468CNV Insertion20534489
    nsv872442CNV Gain21882294
    dgv74n67CNV Gain20364138

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HRNR
    DNA2.0 Custom Variant and Variant Library Synthesis for HRNR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    5 diseases for HRNR:    About MalaCards
    irritant dermatitis    eczema    dermatitis    atopic dermatitis
    breast cancer


    HRNR for disorders           About GeneDecksing

    Genetic Association Database (GAD): HRNR
    Human Genome Epidemiology (HuGE) Navigator: HRNR (1 document)

    Export disorders for HRNR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HRNR gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with HRNR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of human hornerin and its expression in regenerating and psoriatic skin. (PubMed id 15507446)1, 2, 9 Takaishi M.... Huh N.-H. (2005)
    2. Variation in genes of the epidermal differentiation c omplex in German atopic dermatitis patients. (PubMed id 19601998)1, 4 Stemmler S....Hoffjan S. (2009)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. Highly complex peptide aggregates of the S100 fused-type protein hornerin are present in human skin. (PubMed id 19020553)1, 9 Wu Z....SchrAPder J.M. (2009)
    5. Why do cellular proteins linked to K63-polyubiquitin c hains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (2013)
    6. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    7. Hornerin, an S100 family protein, is functional in bre ast cells and aberrantly expressed in breast cancer. (PubMed id 22727333)1 Fleming J.M....Vonderhaar B.K. (2012)
    8. Proteomic identification of common SCF ubiquitin ligas e FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (2012)
    9. Highly efficient purification of protein complexes fro m mammalian cells using a novel streptavidin-binding peptide and hexahistidine t andem tag system: application to Bruton's tyrosine kinase. (PubMed id 21080425)1 Li Y....Vondriska T.M. (2011)
    10. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 388697 HGNC: 20846 AceView: LOC388697 Ensembl:ENSG00000197915 euGenes: HUgn388697
    ECgene: HRNR H-InvDB: HRNR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HRNR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HRNR gene:
    Search GeneIP for patents involving HRNR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
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     Browse Antibodies   Browse Cell Culture Products  
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     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
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     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for HRNR  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for HRNR  
     OriGene qSTAR qPCR primer pairs in human, mouse for HRNR   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for HRNR   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HRNR   OriGene Custom Protein Services for HRNR  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HRNR
     QIAGEN SeqTarget long-range PCR primers for resequencing HRNR
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HRNR
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HRNR
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HRNR
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HRNR
     GenScript Custom Purified and Recombinant Proteins Services for HRNR GenScript cDNA clones with any tag delivered in your preferred vector for HRNR
     GenScript Custom Assay Services for HRNR GenScript Custom Superior Antibodies Services for HRNR
     GenScript Custom overexpressing Cell Line Services for HRNR CloneReady with Over 120,000 Genes
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     Search for Antibodies & Assays

     Regulatory tfbs in HRNR promoter
     Search Chromatin IP Primers for HRNR
     RT2 qPCR Primer Assay in human, mouse / rat HRNR
     Search GNC Networks for HRNR
     SABiosciences Custom PCR Arrays for HRNR
     Search Tocris compounds for HRNR (HORN)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
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     Search Sino Biological for antibodies, proteins & pathways
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
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     Search for Antibodies for HRNR at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for HRNR
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     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for HRNR
     Antibodies for HRNR
     ELISAs for HRNR
     CLIAs for HRNR
     Search LifeMap BioReagents cell lines for HRNR
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRNR
     SwitchGear 3'UTR luciferase reporter plasmids for HRNR
     SwitchGear Promoter luciferase reporter plasmids for HRNR
     Search ThermoFisher Antibodies for HRNR
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HRNR
     inGenious Targeting Laboratory - Custom generated mouse model solutions for HRNR
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HRNR
    Customized:
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     LSBio Antibodies in human, mouse, rat for HRNR
    Customized transgenic rodents for:
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     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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