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Aliases for HRNR Gene

Aliases for HRNR Gene

  • Hornerin 2 3
  • Filaggrin Family Member 3 2 3
  • S100a18 3 4
  • Intermediate Filament-Associated Protein 3
  • S100A16 3
  • FLG3 3

External Ids for HRNR Gene

Summaries for HRNR Gene

GeneCards Summary for HRNR Gene

HRNR (Hornerin) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is TCHHL1.

UniProtKB/Swiss-Prot for HRNR Gene

  • Component of the epidermal cornified cell envelopes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HRNR Gene

Genomics for HRNR Gene

Genomic Location for HRNR Gene

Start:
152,212,044 bp from pter
End:
152,224,301 bp from pter
Size:
12,258 bases
Orientation:
Minus strand

Genomic View for HRNR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HRNR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HRNR Gene

Regulatory Elements for HRNR Gene

Proteins for HRNR Gene

  • Protein details for HRNR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YZ3-HORN_HUMAN
    Recommended name:
    Hornerin
    Protein Accession:
    Q86YZ3
    Secondary Accessions:
    • Q5DT20
    • Q5U1F4

    Protein attributes for HRNR Gene

    Size:
    2850 amino acids
    Molecular mass:
    282390 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HRNR Gene

Proteomics data for HRNR Gene at MOPED

Post-translational modifications for HRNR Gene

  • Forms covalent cross-links mediated by transglutaminase TGM3, between glutamine and the epsilon-amino group of lysine residues (in vitro)
  • Processed during the process of epidermal differentiation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HRNR Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HRNR Gene

Domains for HRNR Gene

Gene Families for HRNR Gene

HGNC:
  • EFHAND :EF-hand domain containing

UniProtKB/Swiss-Prot:

HORN_HUMAN
Domain:
  • Contains 2 EF-hand domains.:
    • Q86YZ3
Family:
  • Belongs to the S100-fused protein family.:
    • Q86YZ3
  • In the N-terminal section; belongs to the S-100 family.:
    • Q86YZ3
genes like me logo Genes that share domains with HRNR: view

Function for HRNR Gene

Molecular function for HRNR Gene

UniProtKB/Swiss-Prot Function: Component of the epidermal cornified cell envelopes.
UniProtKB/Swiss-Prot Induction: By UV-B irradiation.

Gene Ontology (GO) - Molecular Function for HRNR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with HRNR: view

miRNA for HRNR Gene

miRTarBase miRNAs that target HRNR

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HRNR Gene

Localization for HRNR Gene

Subcellular locations from UniProtKB/Swiss-Prot for HRNR Gene

Cytoplasmic granule. Note=Found in keratohyalin granules in the granular cells of the epidermis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HRNR Gene COMPARTMENTS Subcellular localization image for HRNR gene
Compartment Confidence
extracellular 5
cytosol 3
cytoskeleton 2
nucleus 2
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HRNR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001533 cornified envelope IEA --
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IDA 21282207
GO:0030313 cell envelope IDA 21282207
GO:0036457 keratohyalin granule IDA 21282207
genes like me logo Genes that share ontologies with HRNR: view

Pathways for HRNR Gene

SuperPathways for HRNR Gene

No Data Available

Gene Ontology (GO) - Biological Process for HRNR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0031424 keratinization IEA --
GO:0043163 cell envelope organization IDA 21282207
GO:0061436 establishment of skin barrier IEP 23403047
genes like me logo Genes that share ontologies with HRNR: view

No data available for Pathways by source for HRNR Gene

Transcripts for HRNR Gene

mRNA/cDNA for HRNR Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HRNR Gene

Hornerin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HRNR Gene

No ASD Table

Relevant External Links for HRNR Gene

GeneLoc Exon Structure for
HRNR
ECgene alternative splicing isoforms for
HRNR

Expression for HRNR Gene

mRNA expression in normal human tissues for HRNR Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HRNR Gene

SOURCE GeneReport for Unigene cluster for HRNR Gene Hs.490162

mRNA Expression by UniProt/SwissProt for HRNR Gene

Q86YZ3-HORN_HUMAN
Tissue specificity: Expressed in cornified epidermis, psoriatic and regenerating skin after wounding. Found in the upper granular layer and in the entire cornified layer of epidermis.
genes like me logo Genes that share expressions with HRNR: view

Orthologs for HRNR Gene

This gene was present in the common ancestor of chordates.

Orthologs for HRNR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HRNR 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hrnr 16
Hrnr 37
  • 28 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 29 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 31 (a)
OneToMany
chicken
(Gallus gallus)
Aves CRNN 37
  • 14 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 13 (a)
OneToMany
Species with no ortholog for HRNR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HRNR Gene

ENSEMBL:
Gene Tree for HRNR (if available)
TreeFam:
Gene Tree for HRNR (if available)

Paralogs for HRNR Gene

Paralogs for HRNR Gene

Selected SIMAP similar genes for HRNR Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HRNR: view

Variants for HRNR Gene

Sequence variations from dbSNP and Humsavar for HRNR Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1390487 -- 152,222,125(+) AAGTA(A/G)GAAGA intron-variant
rs1496045 -- 152,212,228(-) CACCT(A/G)AAAAA utr-variant-3-prime
rs1496046 -- 152,212,058(-) CATCT(C/G)TGCTT downstream-variant-500B, utr-variant-3-prime
rs1496047 -- 152,212,011(-) ACCAA(A/C)CCAAA downstream-variant-500B
rs2172974 -- 152,214,484(-) TGAAC(A/G)ACACG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for HRNR Gene

Variant ID Type Subtype PubMed ID
nsv872442 CNV Gain 21882294
nsv509468 CNV Insertion 20534489
nsv2877 CNV Insertion 18451855
nsv57 CNV Insertion 15895083
nsv471347 CNV Duplication 19718026
nsv8391 CNV Gain+Loss 18304495
nsv514913 CNV Complex 21397061
esv2159882 CNV Deletion 18987734
dgv74n67 CNV Gain 20364138
esv29399 CNV Gain+Loss 19812545
esv2718106 CNV Deletion 23290073
esv2665574 CNV Deletion 23128226
esv1763423 CNV Deletion 17803354
dgv75n67 CNV Gain 20364138

Relevant External Links for HRNR Gene

HapMap Linkage Disequilibrium report
HRNR

Disorders for HRNR Gene

Relevant External Links for HRNR

Genetic Association Database (GAD)
HRNR
Human Genome Epidemiology (HuGE) Navigator
HRNR
genes like me logo Genes that share disorders with HRNR: view

No data available for UniProtKB/Swiss-Prot for HRNR Gene

Publications for HRNR Gene

  1. Identification of human hornerin and its expression in regenerating and psoriatic skin. (PMID: 15507446) Takaishi M. … Huh N.-H. (J. Biol. Chem. 2005) 3 4 23
  2. Highly complex peptide aggregates of the S100 fused-type protein hornerin are present in human skin. (PMID: 19020553) Wu Z. … SchrAPder J.M. (J. Invest. Dermatol. 2009) 3 23
  3. Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients. (PMID: 19601998) Stemmler S. … Hoffjan S. (Int. J. Immunogenet. 2009) 3 49
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Hornerin is a component of the epidermal cornified cell envelopes. (PMID: 21282207) Henry J. … Simon M. (FASEB J. 2011) 3 4

Products for HRNR Gene

Sources for HRNR Gene

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