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Aliases for HRNR Gene

Aliases for HRNR Gene

  • Hornerin 2 3 3 5
  • Filaggrin Family Member 3 2 3
  • S100a18 3 4
  • Intermediate Filament-Associated Protein 3
  • S100A16 3
  • FLG3 3

External Ids for HRNR Gene

Previous GeneCards Identifiers for HRNR Gene

  • GC01M148998
  • GC01M150451
  • GC01M123561

Summaries for HRNR Gene

GeneCards Summary for HRNR Gene

HRNR (Hornerin) is a Protein Coding gene. Among its related pathways are Immune System. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is FLG2.

UniProtKB/Swiss-Prot for HRNR Gene

  • Component of the epidermal cornified cell envelopes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HRNR Gene

Genomics for HRNR Gene

Regulatory Elements for HRNR Gene

Enhancers for HRNR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F152225 0.6 ENCODE 21.3 -1.7 -1674 1.3 ZNF366 ZNF512 RCOR1 PRDM1 HRNR FLG-AS1 PIR46233
GH01F152188 0.4 ENCODE 18.2 +35.1 35133 1.3 CTCF SIN3A RAD21 ZNF664 GATA3 ZBTB48 POLR2A PATZ1 SCRT2 ZNF143 FLG-AS1 HRNR FLG PIR41917
GH01F152143 0.3 FANTOM5 16.9 +80.4 80390 0.2 HRNR ENSG00000226716 TCHH PUDPP2 S100A11 TCHHL1 ENSG00000229021 LCE3A RPTN
GH01F152107 1.1 Ensembl ENCODE 15.3 +113.9 113944 5.1 HDGF SIN3A FEZF1 ZNF2 ZNF121 ZNF207 ZNF548 ZNF263 SP3 REST MRPL9 ENSG00000229021 HRNR RN7SL444P TCHH PIR33217 TCHHL1
GH01F151721 0.6 ENCODE 12.6 +502.7 502687 0.2 CTCF RFX1 SUZ12 CBX2 SIN3A BMI1 GLIS2 RFX3 EZH2 HRNR ENSG00000229021 MRPL9 OAZ3 ENSG00000232937 ENSG00000250734 SNX27 CGN ENSG00000252840 SELENBP1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HRNR on UCSC Golden Path with GeneCards custom track

Genomic Location for HRNR Gene

152,212,076 bp from pter
152,224,196 bp from pter
12,121 bases
Minus strand

Genomic View for HRNR Gene

Genes around HRNR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HRNR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HRNR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HRNR Gene

Proteins for HRNR Gene

  • Protein details for HRNR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q5DT20
    • Q5U1F4

    Protein attributes for HRNR Gene

    2850 amino acids
    Molecular mass:
    282390 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HRNR Gene

Post-translational modifications for HRNR Gene

  • Forms covalent cross-links mediated by transglutaminase TGM3, between glutamine and the epsilon-amino group of lysine residues (in vitro).
  • Processed during the process of epidermal differentiation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HRNR Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HRNR Gene

Domains & Families for HRNR Gene

Suggested Antigen Peptide Sequences for HRNR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 EF-hand domains.
  • Belongs to the S100-fused protein family.
  • Contains 2 EF-hand domains.
  • Belongs to the S100-fused protein family.
  • In the N-terminal section; belongs to the S-100 family.
genes like me logo Genes that share domains with HRNR: view

Function for HRNR Gene

Molecular function for HRNR Gene

UniProtKB/Swiss-Prot Function:
Component of the epidermal cornified cell envelopes.
UniProtKB/Swiss-Prot Induction:
By UV-B irradiation.

Gene Ontology (GO) - Molecular Function for HRNR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with HRNR: view
genes like me logo Genes that share phenotypes with HRNR: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HRNR Gene

Localization for HRNR Gene

Subcellular locations from UniProtKB/Swiss-Prot for HRNR Gene

Cytoplasmic granule. Note=Found in keratohyalin granules in the granular cells of the epidermis.

Subcellular locations from

Jensen Localization Image for HRNR Gene COMPARTMENTS Subcellular localization image for HRNR gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 3
mitochondrion 2
plasma membrane 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for HRNR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001533 cornified envelope IEA --
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IDA 21282207
GO:0030313 cell envelope IDA 21282207
GO:0036457 keratohyalin granule IDA 21282207
genes like me logo Genes that share ontologies with HRNR: view

Pathways & Interactions for HRNR Gene

SuperPathways for HRNR Gene

SuperPathway Contained pathways
1 Immune System
genes like me logo Genes that share pathways with HRNR: view

Pathways by source for HRNR Gene

2 Reactome pathways for HRNR Gene

Gene Ontology (GO) - Biological Process for HRNR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0031424 keratinization IEA --
GO:0043163 cell envelope organization IDA 21282207
GO:0061436 establishment of skin barrier IEP 23403047
genes like me logo Genes that share ontologies with HRNR: view

No data available for SIGNOR curated interactions for HRNR Gene

Transcripts for HRNR Gene

mRNA/cDNA for HRNR Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HRNR Gene

Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HRNR Gene

No ASD Table

Relevant External Links for HRNR Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HRNR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HRNR Gene

Protein differential expression in normal tissues from HIPED for HRNR Gene

This gene is overexpressed in Urinary Bladder (33.6) and Heart (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HRNR Gene

NURSA nuclear receptor signaling pathways regulating expression of HRNR Gene:


SOURCE GeneReport for Unigene cluster for HRNR Gene:


mRNA Expression by UniProt/SwissProt for HRNR Gene:

Tissue specificity: Expressed in cornified epidermis, psoriatic and regenerating skin after wounding. Found in the upper granular layer and in the entire cornified layer of epidermis.
genes like me logo Genes that share expression patterns with HRNR: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for HRNR Gene

Orthologs for HRNR Gene

This gene was present in the common ancestor of chordates.

Orthologs for HRNR Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HRNR 35
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 31 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 29 (a)
(Mus musculus)
Mammalia Hrnr 35
  • 28 (a)
(Gallus gallus)
Aves CRNN 35
  • 14 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 13 (a)
Species where no ortholog for HRNR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HRNR Gene

Gene Tree for HRNR (if available)
Gene Tree for HRNR (if available)

Paralogs for HRNR Gene

Paralogs for HRNR Gene

(15) SIMAP similar genes for HRNR Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HRNR: view

Variants for HRNR Gene

Sequence variations from dbSNP and Humsavar for HRNR Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10788828 -- 152,219,403(+) GATCC(A/G)TGTTG reference, synonymous-codon
rs10888469 -- 152,224,338(+) TTCTT(C/T)CTGAC upstream-variant-2KB
rs111486574 -- 152,218,690(+) TGGAA(G/T)ACGAA reference, missense
rs111513455 -- 152,217,573(+) GCCCC(A/C)TGTCG reference, missense
rs111539149 -- 152,214,155(+) TGATG(C/T)AGAAC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for HRNR Gene

Variant ID Type Subtype PubMed ID
dgv214e59 CNV duplication 20981092
dgv74n67 CNV gain 20364138
dgv75n67 CNV gain 20364138
esv1763423 CNV deletion 17803354
esv2159882 CNV deletion 18987734
esv2665574 CNV deletion 23128226
esv2718106 CNV deletion 23290073
esv29399 CNV gain+loss 19812545
esv3397333 CNV duplication 20981092
nsv1007097 CNV gain 25217958
nsv1014095 CNV gain 25217958
nsv1075801 CNV duplication 25765185
nsv1115369 CNV duplication 24896259
nsv1152232 CNV duplication 26484159
nsv2877 CNV insertion 18451855
nsv471347 CNV gain 19718026
nsv509468 CNV insertion 20534489
nsv514913 CNV gain 21397061
nsv547853 CNV gain 21841781
nsv57 CNV insertion 15895083
nsv8391 CNV gain+loss 18304495

Variation tolerance for HRNR Gene

Residual Variation Intolerance Score: 100% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.50; 95.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HRNR Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HRNR Gene

Disorders for HRNR Gene

Relevant External Links for HRNR

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HRNR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HRNR Gene

Publications for HRNR Gene

  1. Identification of human hornerin and its expression in regenerating and psoriatic skin. (PMID: 15507446) Takaishi M. … Huh N.-H. (J. Biol. Chem. 2005) 3 4 22 64
  2. Ultraviolet B irradiation induces the expression of hornerin in xenotransplanted human skin. (PMID: 23751202) Makino T. … Shimizu T. (Acta Histochem. 2014) 3 4 64
  3. Hornerin is a component of the epidermal cornified cell envelopes. (PMID: 21282207) Henry J. … Simon M. (FASEB J. 2011) 3 4 64
  4. Highly complex peptide aggregates of the S100 fused-type protein hornerin are present in human skin. (PMID: 19020553) Wu Z. … SchrAPder J.M. (J. Invest. Dermatol. 2009) 3 22 64
  5. Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients. (PMID: 19601998) Stemmler S. … Hoffjan S. (Int. J. Immunogenet. 2009) 3 46 64

Products for HRNR Gene

Sources for HRNR Gene

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