Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HRK Gene

protein-coding   GIFtS: 54
GCID: GC12M117303

Harakiri, BCL2 Interacting Protein

(Previous names: harakiri, BCL2-interacting protein (contains only BH3 domain))
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Harakiri, BCL2 Interacting Protein1 2     HARAKIRI2
Death Protein 51 2     Activator Of Apoptosis Harakiri2
Neuronal Death Protein DP52 3     Activator Of Apoptosis Hrk2
BH3-Interacting Domain-Containing Protein 32 3     BCL2-Interacting Protein2
DP52 5     Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain)2
Harakiri, BCL2-Interacting Protein (Contains Only BH3 Domain)1     BID33

External Ids:    HGNC: 51851   Entrez Gene: 87392   Ensembl: ENSG000001351167   OMIM: 6034475   UniProtKB: O001983   

Export aliases for HRK gene to outside databases

Previous GC identifers: GC12M116138 GC12M116820 GC12M117081 GC12M115710 GC12M115761 GC12M117299 GC12M114308


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for HRK Gene:
This gene encodes a member of the BCL-2 protein family. Members of this family are involved in activating or
inhibiting apoptosis. The encoded protein localizes to intracellular membranes. This protein promotes apoptosis
by interacting with the apoptotic inhibitors BCL-2 and BCL-X(L) via its BH3 domain. Alternate splicing results in
multiple transcript variants. (provided by RefSeq, Oct 2012)

GeneCards Summary for HRK Gene:
HRK (harakiri, BCL2 interacting protein) is a protein-coding gene.

UniProtKB/Swiss-Prot: HRK_HUMAN, O00198
Function: Promotes apoptosis

Gene Wiki entry for HRK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the HRK gene promoter:
         c-Fos   p53   AP-1   ATF-2   c-Jun   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHRK promoter sequence
   Search Chromatin IP Primers for HRK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HRK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.22   Ensembl cytogenetic band:  12q24.22   HGNC cytogenetic band: 12q24.2

HRK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HRK gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M117303:  view genomic region     (about GC identifiers)

Start:
117,293,949 bp from pter      End:
117,319,246 bp from pter
Size:
25,298 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: HRK_HUMAN, O00198 (See protein sequence)
Recommended Name: Activator of apoptosis harakiri  
Size: 91 amino acids; 9884 Da
Subunit: Interacts with BCL2 and BCL2L1. Interacts with C1QBP
2 PDB 3D structures from and Proteopedia for HRK:
2L58 (3D)        2L5B (3D)    

Explore the universe of human proteins at neXtProt for HRK: NX_O00198

Explore proteomics data for HRK at MOPED


See HRK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_003797.1  
ENSEMBL proteins: 
 ENSP00000257572   ENSP00000465379  

HRK Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for HRK
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for HRK
OriGene Custom MassSpec
OriGene Custom Protein Services for HRK
GenScript Custom Purified and Recombinant Proteins Services for HRK
Novus Biologicals HRK Protein
Novus Biologicals HRK Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for HRK

 
Search eBioscience for Proteins for HRK 

 
antibodies-online proteins for HRK 

 
antibodies-online peptides for HRK

HRK Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for HRK
OriGene Antibodies for HRK
OriGene Custom Antibody Services for HRK
Novus Biologicals HRK Antibodies
Search for Antibodies for HRK at Abcam
Cloud-Clone Corp. Antibodies for HRK
ThermoFisher Antibodies for HRK
antibodies-online antibodies for HRK (44 products) 

HRK Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for HRK
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for HRK
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for HRK
Cloud-Clone Corp. CLIAs for HRK
Search eBioscience for ELISAs for HRK 
antibodies-online kits for HRK (6 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
2 InterPro protein domains:
 IPR020728 Bcl2_BH3_motif_CS
 IPR017249 Apoptosis_activator_harakiri

Graphical View of Domain Structure for InterPro Entry O00198

ProtoNet protein and cluster: O00198

UniProtKB/Swiss-Prot: HRK_HUMAN, O00198
Domain: The BH3 motif is required for the induction of cell death


Find genes that share domains with HRK           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: HRK_HUMAN, O00198
Function: Promotes apoptosis

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI14596824
     
Find genes that share ontologies with HRK           About GenesLikeMe


Phenotypes:
     5 GenomeRNAi human phenotypes for HRK:
 Decreased influenza A virus in  Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  Increased cell number in G2M,  
 Increased gamma-H2AX phosphory 

     2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Hrk):
 cellular  nervous system 

Find genes that share phenotypes with HRK           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Hrktm1Nnz for HRK

   genOway: Develop your customized and physiologically relevant rodent model for HRK

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat HRK using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate HRK:
hsa-miR-515-5p hsa-miR-1184 hsa-miR-519e*
SwitchGear 3'UTR luciferase reporter plasmidHRK 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for HRK
Predesigned siRNA for gene silencing in human, mouse, rat HRK

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for HRK

Clone
Products:
     
OriGene clones in human, mouse for HRK (see all 5)
OriGene ORF clones in mouse, rat for HRK
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: HRK (NM_003806)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HRK
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HRK

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for HRK
Browse ESI BIO Cell Lines and PureStem Progenitors for HRK 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRK


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
HRK_HUMAN, O00198: Membrane; Single-pass membrane protein. Mitochondrion
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion5
cytosol2
nucleus1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion IDA15031724
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with HRK           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for HRK About    
See pathways by source

SuperPathContained pathways About
1Apoptosis (WikiPathways)
Apoptosis0.38
Apoptosis Modulation and Signaling0.38
2NGF Pathway
TRKA Signaling0.75
3ATF-2 transcription factor network
ATF-2 transcription factor network
4Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins
Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for HRK
    TRKA Signaling

1 GeneGo (Thomson Reuters) Pathway for HRK
    Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins

3 BioSystems Pathways for HRK
    Apoptosis
Apoptosis Modulation and Signaling
ATF-2 transcription factor network


    Pathway & Disease-focused RT2 Profiler PCR Arrays including HRK: 
          Lymphoma in human mouse rat
          Apoptosis 384HT in human mouse rat
          Apoptosis in human mouse rat

Interactions:

    GeneGlobe Interaction Network for HRK

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

Selected Interacting proteins for HRK (O001981, 3 ENSP000002575724) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
InteractantInteraction Details
GeneCardExternal ID(s)
C1QBPQ070211, 3, ENSP000002256984EBI-701322,EBI-347528 I2D: score=2 STRING: ENSP00000225698
BCL2L1Q07817-11, ENSP000003025644EBI-701322,EBI-287195 I2D: score=5 STRING: ENSP00000302564
BCL2L2Q928433, ENSP000002504054I2D: score=5 STRING: ENSP00000250405
BCL2L2-PABPN1Q928433I2D: score=5 
BCL2P104153, ENSP000003296234I2D: score=4 STRING: ENSP00000329623
About this table

Gene Ontology (GO): 4 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006915apoptotic process IEA--
GO:0032464positive regulation of protein homooligomerization IDA--
GO:0043065positive regulation of apoptotic process IMP15031724
GO:0090200positive regulation of release of cytochrome c from mitochondria IDA--

Find genes that share ontologies with HRK           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for HRK

1 Novoseek inferred chemical compound relationship for HRK gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
calcium 0 1 10779415 (1)



Find genes that share compounds with HRK           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for HRK gene: 
NM_003806.2  

Unigene Cluster for HRK:

Harakiri, BCL2 interacting protein (contains only BH3 domain)
Hs.87247  [show with all ESTs]
Unigene Representative Sequence: NR_073189
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000257572(uc001twe.3) ENST00000552092 ENST00000550505 ENST00000586941

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat HRK using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate HRK:
hsa-miR-515-5p hsa-miR-1184 hsa-miR-519e*
SwitchGear 3'UTR luciferase reporter plasmidHRK 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for HRK
Predesigned siRNA for gene silencing in human, mouse, rat HRK
Clone
Products:
     
OriGene clones in human, mouse for HRK (see all 5)
OriGene ORF clones in mouse, rat for HRK
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: HRK (NM_003806)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HRK
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HRK
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for HRK
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HRK
  QuantiTect SYBR Green Assays in human, mouse, rat HRK
  QuantiFast Probe-based Assays in human, mouse, rat HRK

Additional mRNA sequence: 

D83699.1 NR_073189.1 U76376.1 

3 DOTS entries:

DT.308239  DT.100716408  DT.75136869 

18 AceView cDNA sequences:

U76376 BX118100 NM_003806 D83699 C00709 AI762712 AI083676 BE674890 
BX351422 AA906802 AA418229 BV204371 BX365952 BE165899 AI809746 BF093413 
BF510077 BE247231 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for HRK    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5
SP1:                              
SP2:        -     -     -         


ECgene alternative splicing isoforms for HRK

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

HRK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGGCGGCGCC
HRK Expression
About this image


HRK expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 3) fully expand
 
 Neural Ectoderm (Nervous System)
         Neural ectoderm cells
 
 Neural Tube (Nervous System)
         Spinal Ventral Columns
 
 Spinal Cord (Nervous System)
HRK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

HRK Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.87247
    Pathway & Disease-focused RT2 Profiler PCR Arrays including HRK: 
          Lymphoma in human mouse rat
          Apoptosis 384HT in human mouse rat
          Apoptosis in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for HRK
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HRK
QuantiTect SYBR Green Assays in human, mouse, rat HRK
QuantiFast Probe-based Assays in human, mouse, rat HRK
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRK

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of human and mouse.

Orthologs for HRK gene from Selected species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Hrk5 harakiri, BCL2 interacting protein (contains only BH3 more   --   5 (58.16 cM) 118164648 


ENSEMBL Gene Tree for HRK (if available)
TreeFam Gene Tree for HRK (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for HRK (see all 421)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1816176491,2
--117297734(+) GAACTG/TTACAG 2 -- ds50010--------
rs47674631,2
C,F,H--117297789(+) TAAACG/ATGGAT 2 -- ds500116Minor allele frequency- A:0.04NS EA NA WA CSA 794
rs1512865291,2
--117297907(+) CCGTCC/GGAATC 2 -- ds50010--------
rs1125037301,2
C--117297922(+) CCTGACACCT   
   CGC
/-
CACCT
2 -- ds50011Minor allele frequency- -:0.50CSA 2
rs1161241841,2
C--117297928(+) CACCTC/TGCCAC 2 -- ds50011Minor allele frequency- T:0.01WA 118
rs1177394841,2
C,F--117298004(+) TTTTCG/AAAAAT 2 -- ds50012Minor allele frequency- A:0.02NA EA 240
rs1867978231,2
--117298062(+) TCTCCA/GTCCAG 2 -- ds50010--------
rs772687881,2
C,F--117298073(+) CACACA/TTCTTT 2 -- ds50012Minor allele frequency- T:0.05NA EA 240
rs110682131,2
C,H--117298316(+) GAACTC/TCGAGG 2 -- ut31 nc-transcript-variant4Minor allele frequency- T:0.00NS EA 420
rs1396124111,2
--117298332(+) TTTGTA/GGGGGT 2 -- ut31 nc-transcript-variant0--------

HapMap Linkage Disequilibrium report for HRK (117293949 - 117319246 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for HRK:    About this table    
Variant IDTypeSubtypePubMed ID
nsv898CNV Insertion18451855
nsv832524CNV Gain17160897
nsv826522CNV Gain20364138

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing HRK
DNA2.0 Custom Variant and Variant Library Synthesis for HRK

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 603447    OMIM disorders: --


Find genes that share disorders with HRK           About GenesLikeMe

Genetic Association Database (GAD): HRK
Human Genome Epidemiology (HuGE) Navigator: HRK (5 documents)

Export disorders for HRK gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for HRK gene, integrated from 10 sources (see all 47):
(articles sorted by number of sources associating them with HRK)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L). (PubMed id 9130713)1, 2, 3 Inohara N.... Nunez G. (EMBO J. 1997)
  2. Identification of common variants associated with human hippocampal and intracranial volumes. (PubMed id 22504417)1, 4 Stein J.L....Thompson P.M. (Nat. Genet. 2012)
  3. Common variants at 12q14 and 12q24 are associated with hippocampal volume. (PubMed id 22504421)1, 4 Bis J.C....Seshadri S. (Nat. Genet. 2012)
  4. Intrinsic order and disorder in the BCL-2 member harakiri: insights into its proapoptotic activity. (PubMed id 21731739)1, 2 Barrera-Vilarmau S.... de Alba E. (PLoS ONE 2011)
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  6. Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma. (PubMed id 20855536)1, 4 Kelly J.L....Cerhan J.R. (amp 2010)
  7. Physical and functional interaction between BH3-only protein Hrk and mitochondrial pore-forming protein p32. (PubMed id 15031724)1, 2 Sunayama J.... Kitanaka C. (Cell Death Differ. 2004)
  8. The role of HRK gene in human cancer. (PubMed id 19641496)1, 9 Nakamura M....Konishi N. (Oncogene 2008)
  9. Fas signaling and blockade of Bcr-Abl kinase induce apoptotic Hrk protein via DREAM inhibition in human leukemia cells. (PubMed id 12217801)1, 9 Sanz C....Fernandez-Luna J.L. (Haematologica 2002)
  10. Expression of apoptosis-related genes during human preimplantation embryo development: potential roles for the Harakiri gene product and Caspase-3 in blastomere fragmentation. (PubMed id 12606589)1, 9 Jurisicova A....Casper R.F. (Mol. Hum. Reprod. 2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 8739 HGNC: 5185 AceView: HRK Ensembl:ENSG00000135116 euGenes: HUgn8739
ECgene: HRK H-InvDB: HRK

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for HRK Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for HRK Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for HRK gene:
Search GeneIP for patents involving HRK

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Antibodies for HRK (Hrk)   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Recombinant/Natural Proteins for HRK (Hrk)   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 OriGene Antibodies for HRK   OriGene RNAi products in human, mouse, rat for HRK  
 Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for HRK  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for HRK  
 OriGene qSTAR qPCR primer pairs in human, mouse for HRK   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for HRK   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for HRK   OriGene Custom Protein Services for HRK  

 
 
 Block miRNA regulation of human, mouse, rat HRK using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HRK
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HRK Predesigned siRNA for gene silencing in human, mouse, rat HRK
 QuantiFast Probe-based Assays in human, mouse, rat HRK QuantiTect SYBR Green Assays in human, mouse, rat HRK
 PCR Arrays including human, mouse, rat HRK Search Chromatin IP Primers for HRK
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HRK  GeneGlobe Interaction Network for HRK
 Regulatory tfbs in HRK promoter
 GenScript Custom Purified and Recombinant Proteins Services for HRK GenScript cDNA clones with any tag delivered in your preferred vector for HRK
 GenScript Custom Assay Services for HRK GenScript Custom overexpressing Cell Line Services for HRK
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for HRK
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 HRK antibodies
 HRK proteins
 HRK lysates
 Search for Antibodies for HRK at Abcam
 See all of Abcam's Antibodies, Kits and Proteins for HRK
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for HRK
 Antibodies for HRK
 ELISAs for HRK
 CLIAs for HRK



 Browse ESI BIO Cell Lines and PureStem Progenitors for HRK
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRK
 SwitchGear 3'UTR luciferase reporter plasmids for HRK
 SwitchGear Promoter luciferase reporter plasmids for HRK
 ThermoFisher Antibodies for HRK
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HRK
 Browse compounds at ApexBio
 Search Addgene for plasmids for HRK
  Search eBioscience for proteins for HRK
  Search eBioscience for elisas for HRK
  eBioscience FlowRNA Probe Sets
 genOway: Develop your customized and physiologically relevant rodent model for HRK
 antibodies-online antibodies for HRK (44 products)
 antibodies-online kits for HRK (6 products)
 antibodies-online peptides for HRK
 antibodies-online proteins for HRK
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      HRK gene at Home site.
Version: 3.12.250 16 Nov 2014
hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4