Aliases for HRH4 Gene
External Ids for HRH4 Gene
Previous GeneCards Identifiers for HRH4 Gene
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
GeneCards Summary for HRH4 Gene
HRH4 (Histamine Receptor H4) is a Protein Coding gene. Diseases associated with HRH4 include cerebellar degeneration and paraneoplastic cerebellar degeneration. Among its related pathways are Signaling by GPCR and Akt Signaling. GO annotations related to this gene include histamine receptor activity. An important paralog of this gene is CHRM4.
UniProtKB/Swiss-Prot for HRH4 Gene
The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist).
Histamine H4 receptors are Galphai/o-protein-coupled receptors first cloned in 2000. H4 receptors are expressed at high levels in the gastrointestinal tract, spleen, thymus, medullary cells, bone marrow and peripheral haematopoietic cells, including eosinophils, basophils, mast cells, T lymphocytes, leukocytes and dendritic cells. Moderate expression levels are detected in the brain, heart, liver and lung. H4 receptors have an important role in inflammation, haematopoiesis and immunity and their expression is regulated by stimuli such as IFN, TNF-alpha and IL-6. Activation of this receptor mediates chemotaxis of mast cells and eosinophils and also controls cytokine release from dendritic and T cells. Furthermore, H4 receptors have a role in the differentiation of myeloblasts and promyelocytes. The human gene encoding the H4 receptor is localized to chromosome 18q11.2.