HRH4 Gene
protein-coding GIFtS: 59
GCID: GC18P022040
|
|
histamine receptor H4
| |
Aliases
for HRH4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Histamine Receptor H41 2 | | G-Protein Coupled Receptor 1052 3 | | HH4R1 2 3 5 | | BG262 | | AXOR351 2 3 | | H42 | | GPCR1051 2 3 | | Histamine H4 Receptor2 | | GPRv531 2 3 | | Pfi-0133 | | H4R1 2 3 | | Pfi-0133 | | SP91442 3 | | |
Export aliases for HRH4 gene to outside databasesPrevious GC identifers: GC18P021933 GC18P021772 GC18P020292 GC18P020294 GC18P018896 |
Summaries
for HRH4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HRH4:
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Itsvarious actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptorsuperfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. Theprotein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encodingdifferent isoforms have been found for this gene. (provided by RefSeq, May 2009)
UniProtKB/Swiss-Prot: HRH4_HUMAN, Q9H3N8Function: The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays asignificant level of constitutive activity (spontaneous activity in the absence of agonist)
 summary
for HRH4: Histamine H4 receptors are Galphai/o-protein-coupled receptors first cloned in 2000. H4 receptors are
expressed at high levels in the gastrointestinal tract, spleen, thymus, medullary cells, bone marrow and
peripheral haematopoietic cells, including eosinophils, basophils, mast cells, T lymphocytes, leukocytes and
dendritic cells. Moderate expression levels are detected in the brain, heart, liver and lung. H4 receptors
have an important role in inflammation, haematopoiesis and immunity and their expression is regulated by
stimuli such as IFN, TNF-alpha and IL-6. Activation of this receptor mediates chemotaxis of mast cells and
eosinophils and also controls cytokine release from dendritic and T cells. Furthermore, H4 receptors have a
role in the differentiation of myeloblasts and promyelocytes. The human gene encoding the H4 receptor is
localized to chromosome 18q11.2.
Gene Wiki entry for HRH4 (Histamine H4 receptor)
|
Genomic Views
for HRH4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_010966.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HRH4 gene promoter:
ISGF-3 AML1a POU2F1 AP-1 POU2F1a ATF-2 c-Jun LCR-F1 En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for HRH4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HRH4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18q11.2 Ensembl cytogenetic band: 18q11.2 HGNC cytogenetic band: 18q11.2HRH4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18P022040: view genomic region
(about GC identifiers)
Start:
|
22,040,593 bp from pter |
End:
|
22,059,921 bp from pter |
Size:
|
19,329 bases |
Orientation:
|
plus strand |
|
Proteins
for HRH4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HRH4_HUMAN, Q9H3N8 (See
protein sequence)Recommended Name: Histamine H4 receptor Size: 390 amino acids; 44496 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Miscellaneous: Does not bind diphenhydramine, loratadine, ranitidine, cimetidine and chlorpheniramine. Shows modestaffinity for dimaprit, impromidine, clobenpropit, thioperamide, burimamide clozapine, immepip and imetit. The order ofinhibitory activity was imetit > clobenpropit > burimamide > thioperamide. Clobenpropit behaves as a partial agonist,dimaprit and impromidine show some agonist activity while clozapine behaves as a full agonist. Thioperamide showsinverse agonism (enhances cAMP activity). The order of inhibitory activity of histamine derivatives was Histamine >N-alpha-methylhistamine > R(-)-alpha-methylhistamine > S(+)-alpha-methylhistamine. Both N-alpha-methylhistamine >R(-)-alpha-methylhistamine behave as full agonists
Secondary accessions: B0YJ19 B2KJ48 Q4G0I6 Q9GZQ0Alternative splicing: 2 isoforms: Q9H3N8-1 Q9H3N8-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for HRH4: NX_Q9H3N8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H3N8
HRH4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001137300.1 NP_001153638.1 NP_067637.2
ENSEMBL proteins: ENSP00000256906 ENSP00000402526 Reactome Protein details: Q9H3N8
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
HRH4 for ontologies About GeneDecksing
HRH4 Antibody Products:
Assay Products for HRH4: |
Protein
Domains /
Families
for HRH4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HRH4 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H3N8ProtoNet protein and cluster: Q9H3N8 1 Blocks protein family: IPB008102 Histamine H4 receptor signature
UniProtKB/Swiss-Prot: HRH4_HUMAN, Q9H3N8Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for HRH4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: HRH4_HUMAN, Q9H3N8Function: The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays asignificant level of constitutive activity (spontaneous activity in the absence of agonist)Induction: Expression is either up-regulated or down-regulated upon activation of the lymphoid tissues and thisregulation may depend on the presence of IL10/interleukin-10 or IL13/interleukin-13
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HRH4 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HRH4 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): HRH4 (NM_021624) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HRH4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HRH4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRH4 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
HRH4 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Hrh4tm1Lex for HRH4
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Hrh4):
HRH4 for phenotypes About GeneDecksing
|
Pathways & Interactions
for HRH4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Akt Signaling | | | 3 | Signaling by GPCR | | | 4 | Histamine receptors | | | 5 | GPCRs, Other | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HRH4 (see all 7)
1  BioSystems Pathway for HRH4
5/8 
Reactome Pathways for HRH4 (see all 8)
1 
Kegg Pathway (Kegg details for HRH4):
HRH4 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HRH4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/146 Interacting proteins for HRH4 (Q9H3N83 ENSP000002569064) via UniProtKB, MINT, STRING, and/or I2D (see all 146)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006954 | inflammatory response |
-- | -- | | GO:0008150 | biological_process |
ND | -- |
HRH4 for ontologies About GeneDecksing
|
Drugs & Compounds
for HRH4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
HRH4 for compounds About GeneDecksing
Compounds for HRH4 available from Tocris Bioscience About this table
3 HMDB Compounds for HRH4 About this table
2 DrugBank Compounds for HRH4 About this table
7 Novoseek chemical compound relationships for HRH4 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| 4-methylhistamine |
93 |
12 |
19281909 (1), 20103609 (1), 15947036 (1), 17507084 (1) (see all 5) |
| clobenpropit |
92.5 |
9 |
19414267 (2), 19281909 (1), 12235264 (1), 17507084 (1) (see all 5) |
| thioperamide |
87.3 |
7 |
20103609 (1), 11118334 (1), 19720730 (1) |
| histamine |
84.1 |
58 |
19166345 (6), 11118334 (3), 11179434 (2), 18639542 (2) (see all 27) |
| clozapine |
48.6 |
1 |
19413571 (1) |
| amine |
19.9 |
1 |
12824482 (1) |
| calcium |
3.76 |
1 |
19413570 (1) |
Search CenterWatch for drugs/clinical trials and news about HRH4
|
Transcripts
for HRH4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HRH4 gene (3 alternative transcripts): NM_001143828.1 NM_001160166.1 NM_021624.3 Unigene Cluster for HRH4: Histamine receptor H4 Hs.287388 [show with all ESTs]Unigene Representative Sequence: AF3122302 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000256906(uc002kvi.3 uc010xbd.2 uc010dlx.3) ENST00000426880
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HRH4 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HRH4 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): HRH4 (NM_021624) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HRH4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HRH4 |
Additional cDNA sequence: AB044934.1 AB045370.1 AF307973.1 AF312230.1 AF325356.1 AF329449.1 AJ298292.1 AY008280.1 AY136745.1 BC069136.1 BC112348.1 DQ835186.1 DQ835187.1 1 DOTS entry: DT.97836902 13 AceView cDNA sequences: AY136745 CF147821 AF307973 AJ298292 AF329449 BC069136 AY008280 AF325356 AB045370 NM_021624 AF312230 AB044934 BX643713
GeneLoc Exon Structure
|
Expression
for HRH4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HRH4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTAACATTC
About this image
See HRH4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HRH4
SOURCE GeneReport for Unigene cluster: Hs.287388
UniProtKB/Swiss-Prot: HRH4_HUMAN, Q9H3N8Tissue specificity: Expressed primarily in the bone marrow and eosinophils. Shows preferential distribution in cells ofimmunological relevance such as T-cells, dendritic cells, monocytes, mast cells, neutrophils. Also expressed in a widevariety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, smallintestine, spleen, testis, colon, fetal liver and lymph node
SABiosciences Expression via Pathway-Focused PCR Arrays including HRH4:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HRH4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HRH4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HRH4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HRH4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRH4 |
Orthologs
for HRH4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for HRH4 gene from 2/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
E1C7I3_CHICK6 |
Uncharacterized protein |
40(a) |
1 ↔ 1 |
2(106554028-106560258) |
zebrafish
(Danio rerio) |
Actinopterygii |
CABZ01084564.16CABZ01078515.16 |
-- |
39(a)37(a) |
1 ↔ many1 ↔ many |
2(1358788-1372630) 22(1111647-1145152) |
ENSEMBL Gene Tree for HRH4 (if available)
TreeFam Gene Tree for HRH4 (if available) |
Paralogs
for HRH4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HRH4 gene
- CHRM52 HRH12 CHRM12 CHRM22 HRH32 CHRM42 CHRM32
2 SIMAP similar genes for HRH4 using alignment to 1 protein entry: HRH4_HUMAN:H4 HRH3
HRH4 for paralogs About GeneDecksing
|
Genomic Variants
for HRH4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HRH4 (22040593 - 22059921 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HRH4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HRH4 |
|
Disorders
/ Diseases
for HRH4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HRH4 for disorders About GeneDecksing
OMIM gene information: 606792
OMIM disorders: --
20/22  diseases for HRH4 (see all 22): About MalaCardsparaneoplastic cerebellar degeneration cerebellar degeneration systemic lupus erythematosus allergic rhinitis
lupus erythematosus atopic dermatitis pericarditis neuronitis
dermatitis cramps rhinitis rheumatoid arthritis
hepatitis b choroiditis pancreatic carcinoma arthritis
psoriasis colorectal cancer pancreatitis hepatitis
3 diseases from the University of Copenhagen DISEASES database for HRH4:Asthma Hypersensitivity reaction type I disease Allergic rhinitis 5 Novoseek disease relationships for HRH4 gene About this table
Human Genome Epidemiology (HuGE) Navigator: HRH4 (5 documents)
Export disorders for HRH4 gene to outside databases
|
Publications
for HRH4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HRH4 gene, integrated from 9 sources (see all 123):
(articles sorted by number of sources associating them with HRH4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning and characterization of a new human histamine receptor, HH4R. (PubMed id 11118334)1, 2, 3, 9 Nakamura T.... Tanaka K. (2000)
- Molecular cloning and characterization of a novel type of histamine receptor preferentially expressed in leukocytes. (PubMed id 10973974)1, 2, 3 Oda T....Matsumoto S. (2000)
- Cloning, expression, and pharmacological characterization of a novel human histamine receptor. (PubMed id 11179436)1, 2, 9 Zhu Y.... Fitzgerald L.R. (2001)
- Cloning and pharmacological characterization of a fourth histamine receptor (H4) expressed in bone marrow. (PubMed id 11179434)1, 2, 9 Liu C.... Lovenberg T.W. (2001)
- Cloning and characterization of dominant negative splice variants of the human histamine H4 receptor. (PubMed id 18452403)1, 2, 9 van Rijn R.M.... Leurs R. (2008)
- Copy number variations of the human histamine H4 rece ptor gene are associated with systemic lupus erythematosus. (PubMed id 20618322)1, 7 Yu B....Zhang W. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Cloning and characterization of a novel human histamine receptor. (PubMed id 11181941)1, 2 Morse K.L....Monsma F.J. Jr. (2001)
- Histamine downregulates monocyte CCL2 production through the histamine H4 receptor. (PubMed id 17507084)1, 9 Dijkstra D....Gutzmer R. (2007)
- High constitutive activity and a G-protein-independen t high-affinity state of the human histamine H(4)-receptor. (PubMed id 19166345)1, 9 Schneider E.H....Seifert R. (2009)
|
External Searches for HRH4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HRH4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HRH4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HRH4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HRH4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HRH4 gene:
Search GeneIP for patents involving HRH4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HRH4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for HRH4 | | OriGene shRNA RFP for HRH4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HRH4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HRH4 | | | OriGene Protein Over-expression Lysate for HRH4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HRH4 | | OriGene 3'-UTR Clone for HRH4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HRH4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HRH4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HRH4 | | OriGene Custom Protein Services for HRH4 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HRH4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HRH4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HRH4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HRH4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HRH4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HRH4 |
| |
 |  |  |  | |
| | | | Tocris compounds for HRH4 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | HRH4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRH4 |
|  |  |  | | | | ThermoFisher Antibodies for HRH4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HRH4 |
|
|
|
|
