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HRH4 Gene

protein-coding   GIFtS: 63
GCID: GC18P022040

Histamine Receptor H4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Histamine Receptor H41 2     G-Protein Coupled Receptor 1052 3
HH4R2 3 5     BG262
AXOR352 3     H42
GPCR1052 3     Histamine H4 Receptor2
GPRv532 3     pfi-0132
H4R2 3     Pfi-0133
SP91442 3     

External Ids:    HGNC: 173831   Entrez Gene: 593402   Ensembl: ENSG000001344897   OMIM: 6067925   UniProtKB: Q9H3N83   

Export aliases for HRH4 gene to outside databases

Previous GC identifers: GC18P021933 GC18P021772 GC18P020292 GC18P020294 GC18P018896


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HRH4 Gene:
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons.
Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled
receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic
cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, May 2009)

GeneCards Summary for HRH4 Gene:
HRH4 (histamine receptor H4) is a protein-coding gene. Diseases associated with HRH4 include paraneoplastic cerebellar degeneration, and cerebellar degeneration. GO annotations related to this gene include histamine receptor activity. An important paralog of this gene is HTR2A.

UniProtKB/Swiss-Prot: HRH4_HUMAN, Q9H3N8
Function: The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues.
Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist)

summary for HRH4 Gene:
Histamine H4 receptors are Galphai/o-protein-coupled receptors first cloned in 2000. H4 receptors are
expressed at high levels in the gastrointestinal tract, spleen, thymus, medullary cells, bone marrow and
peripheral haematopoietic cells, including eosinophils, basophils, mast cells, T lymphocytes, leukocytes and
dendritic cells. Moderate expression levels are detected in the brain, heart, liver and lung. H4 receptors
have an important role in inflammation, haematopoiesis and immunity and their expression is regulated by
stimuli such as IFN, TNF-alpha and IL-6. Activation of this receptor mediates chemotaxis of mast cells and
eosinophils and also controls cytokine release from dendritic and T cells. Furthermore, H4 receptors have a
role in the differentiation of myeloblasts and promyelocytes. The human gene encoding the H4 receptor is
localized to chromosome 18q11.2.

Gene Wiki entry for HRH4 (Histamine H4 receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000018.10  NC_018929.2  NT_010966.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the HRH4 gene promoter:
         ISGF-3   AML1a   POU2F1   AP-1   POU2F1a   ATF-2   c-Jun   LCR-F1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHRH4 promoter sequence
   Search Chromatin IP Primers for HRH4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HRH4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q11.2   Ensembl cytogenetic band:  18q11.2   HGNC cytogenetic band: 18q11.2

HRH4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HRH4 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P022040:  view genomic region     (about GC identifiers)

Start:
22,040,593 bp from pter      End:
22,059,921 bp from pter
Size:
19,329 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: HRH4_HUMAN, Q9H3N8 (See protein sequence)
Recommended Name: Histamine H4 receptor  
Size: 390 amino acids; 44496 Da
Miscellaneous: Does not bind diphenhydramine, loratadine, ranitidine, cimetidine and chlorpheniramine. Shows
modest affinity for dimaprit, impromidine, clobenpropit, thioperamide, burimamide clozapine, immepip and imetit.
The order of inhibitory activity was imetit > clobenpropit > burimamide > thioperamide. Clobenpropit behaves as a
partial agonist, dimaprit and impromidine show some agonist activity while clozapine behaves as a full agonist.
Thioperamide shows inverse agonism (enhances cAMP activity). The order of inhibitory activity of histamine
derivatives was Histamine > N-alpha-methylhistamine > R(-)-alpha-methylhistamine > S(+)-alpha-methylhistamine.
Both N-alpha-methylhistamine > R(-)-alpha-methylhistamine behave as full agonists
Secondary accessions: B0YJ19 B2KJ48 Q4G0I6 Q9GZQ0
Alternative splicing: 2 isoforms:  Q9H3N8-1   Q9H3N8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HRH4: NX_Q9H3N8

Explore proteomics data for HRH4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5, Asn9

  • See HRH4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001137300.1  NP_001153638.1  NP_067637.2  

    ENSEMBL proteins: 
     ENSP00000256906   ENSP00000402526  
    Reactome Protein details: Q9H3N8

    HRH4 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for HRH4
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    Cloud-Clone Corp. ELISAs for HRH4
    Cloud-Clone Corp. CLIAs for HRH4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HRH: GPCR / Class A : Histamine receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: H4 receptor
    Histamine receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn
     IPR008102 Histamine_H4_rcpt

    Graphical View of Domain Structure for InterPro Entry Q9H3N8

    ProtoNet protein and cluster: Q9H3N8

    1 Blocks protein domain: IPB008102 Histamine H4 receptor signature

    UniProtKB/Swiss-Prot: HRH4_HUMAN, Q9H3N8
    Similarity: Belongs to the G-protein coupled receptor 1 family


    HRH4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HRH4_HUMAN, Q9H3N8
    Function: The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues.
    Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist)
    Induction: Expression is either up-regulated or down-regulated upon activation of the lymphoid tissues and this
    regulation may depend on the presence of IL10/interleukin-10 or IL13/interleukin-13

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004969histamine receptor activity NAS10973974
         
    HRH4 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hrh4):
     hematopoietic system  homeostasis/metabolism  immune system 

    HRH4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Hrh4tm1Lex for HRH4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HRH4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HRH4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HRH4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HRH4

    miRNA
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    miRTarBase miRNAs that target HRH4:
    hsa-mir-335-5p (MIRT017500), hsa-mir-148b-3p (MIRT019358)

    Block miRNA regulation of human, mouse, rat HRH4 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate HRH4:
    hsa-miR-489 hsa-miR-944 hsa-miR-3190 hsa-miR-371-5p hsa-miR-4282 hsa-miR-1305 hsa-miR-3162-5p hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidHRH4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HRH4
    Predesigned siRNA for gene silencing in human, mouse, rat HRH4

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): HRH4 (NM_021624)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HRH4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HRH4

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for HRH4 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRH4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HRH4_HUMAN, Q9H3N8: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    HRH4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HRH4 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    4Monoamine GPCRs
    Amine ligand-binding receptors0.79
    Histamine receptors0.00
    5PAK Pathway
    Antioxidant Action of Vitamin-C0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HRH4 (see all 7)
        Chemokine Signaling
    STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    p38 Signaling

    1 BioSystems Pathway for HRH4
        GPCRs, Other

    2 Reactome Pathways for HRH4
        G alpha (i) signalling events
    Histamine receptors


    1 Kegg Pathway  (Kegg details for HRH4):
        Neuroactive ligand-receptor interaction


    HRH4 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HRH4: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for HRH4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HRH4 (Q9H3N83 ENSP000002569064) via UniProtKB, MINT, STRING, and/or I2D (see all 146)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCL16O154673, ENSP000002932754I2D: score=1 STRING: ENSP00000293275
    GNA15P306793, ENSP000002629584I2D: score=1 STRING: ENSP00000262958
    GNAO1P094713, ENSP000002624934I2D: score=1 STRING: ENSP00000262493
    GNAI1P630963, ENSP000003430274I2D: score=1 STRING: ENSP00000343027
    ADCY2ENSP000003429524STRING: ENSP00000342952
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response IEA--
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007204positive regulation of cytosolic calcium ion concentration IEA--
    GO:0008150biological_process ND--
    GO:0043408regulation of MAPK cascade IEA--

    HRH4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for HRH4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    A 943931 dihydrochloridePotent and selective H4 antagonist[1227675-50-4]
    4-Methylhistamine dihydrochloride Selective, high affinity H4 agonist [36376-47-3]
    JNJ 7777120Selective H4 receptor antagonist[459168-41-3]
    A 987306Potent and selective H4 receptor antagonist[1082954-71-9]
    VUF 8430 dihydrobromide Potent, high affinity H4 agonist [100130-32-3]

    3 HMDB Compounds for HRH4    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorpheniramineChlor-trimeton (see all 8)113-92-8--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Histamine1H-Imidazole-4-ethanamine (see all 27)51-45-6--

    2 DrugBank Compounds for HRH4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Clozapine-- 5786-21-0targetantagonist16854056 17346280 16860312 11752352
    Histamine Phosphate-- 51-74-1targetagonist20573261 20618322 20632959

    Selected IUPHAR Ligands for HRH4 (H4 receptor) (see all 33)    About this table
    LigandTypeActionAffinityPubmed IDs
    imetit
    AgonistFull agonist8.2 - 8.911179434 11179436 11561071 11181941
    [3H]JNJ 7777120
    AntagonistAntagonist8.414722321
    [3H]histamine
    AgonistFull agonist7.4 - 8.411179434 10973974 11561071 11181941 11179435 16432504
    histamine
    AgonistFull agonist7.8 - 8.311179434 11179436 15947036 16432504 15454206 11561071 11181941
    clobenpropit
    AgonistPartial agonist7.4 - 8.311179434 12606603 11561071 11181941 15947036
    JNJ 7777120
    AntagonistAntagonist7.8 - 8.315947036 14722321 16854056
    4-methylhistamine
    AgonistFull agonist7.3 - 8.215947036 16432504
    CCL16
    AgonistFull agonist8.115265943
    immepip
    AgonistFull agonist7.6 - 811179434 14640553 11179436
    impromidine
    AgonistPartial agonist7.6 - 7.911179434 15947036

    7 Novoseek inferred chemical compound relationships for HRH4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    4-methylhistamine 93 12 19281909 (1), 20103609 (1), 15947036 (1), 17507084 (1) (see all 5)
    clobenpropit 92.5 9 19414267 (2), 19281909 (1), 12235264 (1), 17507084 (1) (see all 5)
    thioperamide 87.3 7 20103609 (1), 11118334 (1), 19720730 (1)
    histamine 84.1 58 19166345 (6), 11118334 (3), 11179434 (2), 18639542 (2) (see all 27)
    clozapine 48.6 1 19413571 (1)
    amine 19.9 1 12824482 (1)
    calcium 3.76 1 19413570 (1)



    HRH4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HRH4 gene (3 alternative transcripts): 
    NM_001143828.1  NM_001160166.1  NM_021624.3  

    Unigene Cluster for HRH4:

    Histamine receptor H4
    Hs.287388  [show with all ESTs]
    Unigene Representative Sequence: AF312230
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256906(uc002kvi.3 uc010xbd.2 uc010dlx.3) ENST00000426880

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    8 qRT-PCR Assays for microRNAs that regulate HRH4:
    hsa-miR-489 hsa-miR-944 hsa-miR-3190 hsa-miR-371-5p hsa-miR-4282 hsa-miR-1305 hsa-miR-3162-5p hsa-miR-570
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): HRH4 (NM_021624)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat HRH4
      QuantiFast Probe-based Assays in human, mouse, rat HRH4

    Additional mRNA sequence: 

    AB044934.1 AB045370.1 AF307973.1 AF312230.1 AF325356.1 AF329449.1 AJ298292.1 AY008280.1 
    AY136745.1 BC069136.1 BC112348.1 DQ835186.1 DQ835187.1 

    1 DOTS entry:

    DT.97836902 

    13 AceView cDNA sequences:

    AB045370 AY136745 CF147821 AF329449 AY008280 AF307973 AJ298292 BC069136 
    AF325356 AB044934 NM_021624 AF312230 BX643713 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HRH4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTAACATTC
    HRH4 Expression
    About this image

    HRH4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HRH4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.287388

    UniProtKB/Swiss-Prot: HRH4_HUMAN, Q9H3N8
    Tissue specificity: Expressed primarily in the bone marrow and eosinophils. Shows preferential distribution in
    cells of immunological relevance such as T-cells, dendritic cells, monocytes, mast cells, neutrophils. Also
    expressed in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal
    muscle, prostate, small intestine, spleen, testis, colon, fetal liver and lymph node

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HRH4: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat HRH4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRH4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HRH4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hrh41 , 5 histamine receptor H41, 5 75.66(n)1
    68.89(a)1
      18 (6.88 cM)5
    2251921  NM_153087.21  NP_694727.11 
     130069905 
    chicken
    (Gallus gallus)
    Aves --
    --
    Uncharacterized protein
    52(a)
    35(a)
    1 ↔ many
    1 ↔ many
    2(103069764-103075234)
    2(103057877-103075693)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    34(a)
    many ↔ many
    LGc(3636602-3646953)
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01078515.16
    Uncharacterized protein
    37(a)
    many ↔ many
    22(1111647-1145152) ENSDARG00000060458
    fruit fly
    (Drosophila melanogaster)
    Insecta CG79186
    --
    10(a)
    1 → many
    3R(3885006-3912767)
    worm
    (Caenorhabditis elegans)
    Secernentea gar-26
    gar-16
    Protein GAR-2, isoform d
    Protein GAR-1, isoform c (gar-1) mRNA, complete cd...
    13(a)
    13(a)
    many ↔ many
    many ↔ many
    III(6309378-6320871) WBGene00001518
    X(6479638-6484810) WBGene00001517


    ENSEMBL Gene Tree for HRH4 (if available)
    TreeFam Gene Tree for HRH4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HRH4 gene
    HTR2A2  DRD42  DRD22  CHRM12  CHRM22  HRH32  HTR2B2  HTR2C2  
    HRH12  CHRM52  DRD32  CHRM42  CHRM32  
    2 SIMAP similar genes for HRH4 using alignment to 1 protein entry:     HRH4_HUMAN:
    H4    HRH3

    HRH4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HRH4 (see all 496)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs774236251,2
    --22038598(+) ACACTC/TATACC 3 -- us2k10--------
    rs1493582741,2
    C--22038714(+) TTCTT-/TCTGTTT 3 -- us2k10--------
    rs599231691,2
    C--22038715(+) TCTTT-/CT/TC 
            
    GTTTC
    3 -- us2k10--------
    rs1128704171,2
    C,F--22038739(+) TCATTG/TAGCTT 3 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1851255631,2
    C--22038777(+) GAAACA/GTTTTA 3 -- us2k10--------
    rs1442540841,2
    C--22038885(+) CCTTAA/GTGATA 3 -- us2k10--------
    rs455210311,2
    C,F--22038886(+) CTTAGT/GGATAC 3 -- us2k15Minor allele frequency- G:0.25NS WA CSA 159
    rs1880000391,2
    --22038920(+) TTTATC/TTCTGT 3 -- us2k10--------
    rs1930092761,2
    --22039064(+) AAAAAG/TCTTCT 3 -- us2k10--------
    rs455619431,2
    C,F--22039086(+) TATCTT/CTTTGA 3 -- us2k14Minor allele frequency- C:0.25NS WA CSA 157

    HapMap Linkage Disequilibrium report for HRH4 (22040593 - 22059921 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for HRH4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2716869CNV Deletion23290073
    nsv521369CNV Gain19592680
    nsv909461CNV Gain21882294

    Human Gene Mutation Database (HGMD): HRH4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HRH4
    DNA2.0 Custom Variant and Variant Library Synthesis for HRH4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606792    OMIM disorders: --

    Selected diseases for HRH4 (see all 24):    About MalaCards
    paraneoplastic cerebellar degeneration    cerebellar degeneration    pericarditis    atopic dermatitis
    allergic rhinitis    dermatitis    rhinitis    choroiditis
    asthma    psoriasis    systemic lupus erythematosus    lupus erythematosus
    hepatitis b    osteoarthritis    rheumatoid arthritis    arthritis
    colorectal cancer    neuronitis    hepatitis    endotheliitis

    3 diseases from the University of Copenhagen DISEASES database for HRH4:
    Asthma     Hypersensitivity reaction type I disease     Allergic rhinitis

    HRH4 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for HRH4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    allergic reaction 39.7 2 19720730 (2)
    dermatitis atopic 37.7 3 19281909 (1), 18239617 (1)
    allergy 33.9 2 11179434 (1), 19652466 (1)
    inflammation 29.4 4 18639542 (1), 16054239 (1), 18239617 (1), 20012759 (1)
    asthma 26.8 3 11179434 (1), 19652466 (1), 19720730 (1)

    Genetic Association Database (GAD): HRH4
    Human Genome Epidemiology (HuGE) Navigator: HRH4 (5 documents)

    Export disorders for HRH4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HRH4 gene, integrated from 10 sources (see all 131):
    (articles sorted by number of sources associating them with HRH4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a new human histamine receptor, HH4R. (PubMed id 11118334)1, 2, 3, 9 Nakamura T.... Tanaka K. (Biochem. Biophys. Res. Commun. 2000)
    2. Copy number variations of the human histamine H4 receptor gene are associated with systemic lupus erythematosus. (PubMed id 20618322)1, 4, 7 Yu B....Zhang W. (Br. J. Dermatol. 2010)
    3. Molecular cloning and characterization of a novel type of histamine receptor preferentially expressed in leukocytes. (PubMed id 10973974)1, 2, 3 Oda T.... Matsumoto S. (J. Biol. Chem. 2000)
    4. Cloning, expression, and pharmacological characterization of a novel human histamine receptor. (PubMed id 11179436)1, 2, 9 Zhu Y.... Fitzgerald L.R. (Mol. Pharmacol. 2001)
    5. Cloning and pharmacological characterization of a fourth histamine receptor (H4) expressed in bone marrow. (PubMed id 11179434)1, 2, 9 Liu C.... Lovenberg T.W. (Mol. Pharmacol. 2001)
    6. Cloning and characterization of dominant negative splice variants of the human histamine H4 receptor. (PubMed id 18452403)1, 2, 9 van Rijn R.M.... Leurs R. (Biochem. J. 2008)
    7. Polymorphisms in human histamine receptor H4 gene are associated with atopic dermatitis. (PubMed id 20199554)1, 4, 9 Yu B....Wan J. (Br. J. Dermatol. 2010)
    8. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    9. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (Eur. J. Hum. Genet. 2009)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 59340 HGNC: 17383 AceView: HRH4 Ensembl:ENSG00000134489 euGenes: HUgn59340
    ECgene: HRH4 Kegg: 59340 H-InvDB: HRH4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HRH4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for HRH4 gene:
    Search GeneIP for patents involving HRH4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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