Aliases for HRH4 Gene
External Ids for HRH4 Gene
Previous GeneCards Identifiers for HRH4 Gene
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
GeneCards Summary for HRH4 Gene
HRH4 (Histamine Receptor H4) is a Protein Coding gene. Diseases associated with HRH4 include paraneoplastic cerebellar degeneration and allergic hypersensitivity disease. Among its related pathways are Signaling by GPCR and ERK Signaling. GO annotations related to this gene include G-protein coupled receptor activity and histamine binding. An important paralog of this gene is CHRM4.
UniProtKB/Swiss-Prot for HRH4 Gene
The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist).
Histamine H4 receptors are Galphai/o-protein-coupled receptors, first cloned in 2000. H4 receptors are expressed at high levels in the gastrointestinal tract, spleen, thymus, medullary cells, bone marrow and peripheral hematopoietic cells, including eosinophils and T lymphocytes.