HRH3 Gene
protein-coding GIFtS: 63
GCID: GC20M060790
|
|
histamine receptor H3
| |
Aliases
for HRH3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Histamine Receptor H31 2 | | G-Protein Coupled Receptor 972 3 | | GPCR971 2 3 | | G Protein-Coupled Receptor 972 | | H3R2 3 | | Histamine H3 Receptor2 | | HH3R2 3 | | |
Export aliases for HRH3 gene to outside databasesPrevious GC identifers: GC20M060553 GC20M061428 GC20M061475 GC20M060223 GC20M057566 |
Summaries
for HRH3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HRH3:
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Itsvarious actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histaminereceptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein andcan regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smoothmuscles and innervates the blood vessels and the heart in cardiovascular system. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: HRH3_HUMAN, Q9Y5N1Function: The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervoussystem. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneousactivity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity norinduced intracellular calcium mobilization
 summary
for HRH3: Histamine H3 receptors are Galphai/o-protein-coupled receptors first cloned in 1999. H3 receptors are
expressed at high levels on histaminergic neurons in the central nervous system, particularly in the basal
ganglia, cortex, hippocampus and strial area. They are expressed in the periphery at lower densities in the
gastrointestinal, bronchial and cardiovascular systems. H3 receptors are thought to function as presynaptic
autoreceptors, and activation stimulates the negative feedback mechanism that reduces central histaminergic
activity. These receptors have displayed heterogeneity in binding and functional studies, suggesting
multiple subtypes. In rats, three H3 receptor subtypes have been indentified and they all vary in the length
of the third extracellular loop, have distinct CNS localization and differentially couple to adenylyl
cyclase and MAPK signaling pathways. H3 receptors have multiple functions including roles in cognition,
sleep-wake status, energy homeostasis regulation and inflammation. Activation of these receptors can inhibit
histamine, dopamine, serotonin, noradrenalin and acetylcholine release and they participate in control of
neurogenic inflammation through local-neuron feedback loops. Furthermore, H3 receptor activation increases
antigen-presenting cell capacity. H3 receptors are thought to have pathophysiological relevance and are
involved in cognitive impairment, seizures and possibly metabolic syndrome. The human gene encoding this
receptor is localized to chromosome 20q13.33.
Gene Wiki entry for HRH3 (Histamine H3 receptor)
|
Genomic Views
for HRH3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HRH3 gene promoter:
ER-alpha USF1 Spz1 HTF Olf-1 C/EBPalpha Arnt CBF-A USF-1 CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for HRH3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HRH3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.33 Ensembl cytogenetic band: 20q13.33 HGNC cytogenetic band: 20pter-p12.1HRH3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M060790: view genomic region
(about GC identifiers)
Start:
|
60,790,017 bp from pter |
End:
|
60,795,323 bp from pter |
Size:
|
5,307 bases |
Orientation:
|
minus strand |
|
Proteins
for HRH3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HRH3_HUMAN, Q9Y5N1 (See
protein sequence)Recommended Name: Histamine H3 receptor Size: 445 amino acids; 48671 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Miscellaneous: Does not bind to cimetidine and tripolidine. Shows modest affinity for thioperamide, imetit,N-alpha-methylhistamine and R(-)-alpha-methylhistamine. Isoform 4 is unable to bind to iodoproxyfan while isoforms 1and 3 bind it with high affinity
Secondary accessions: Q4QRI7 Q9GZX2 Q9H4K8Alternative splicing: 7 isoforms: Q9Y5N1-1 Q9Y5N1-2 Q9Y5N1-3 Q9Y5N1-4 Q9Y5N1-5 Q9Y5N1-6 Q9Y5N1-7 Explore the universe of human proteins at neXtProt for HRH3: NX_Q9Y5N1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y5N1
HRH3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_009163.2
ENSEMBL proteins: ENSP00000342560 ENSP00000321482 Reactome Protein details: Q9Y5N1
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
HRH3 for ontologies About GeneDecksing
HRH3 Antibody Products:
Assay Products for HRH3: |
Protein
Domains /
Families
for HRH3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HRH3 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y5N1ProtoNet protein and cluster: Q9Y5N1 1 Blocks protein family: IPB003980 Histamine H3 receptor signature
UniProtKB/Swiss-Prot: HRH3_HUMAN, Q9Y5N1Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for HRH3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: HRH3_HUMAN, Q9Y5N1Function: The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervoussystem. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneousactivity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity norinduced intracellular calcium mobilization
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HRH3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HRH3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HRH3 (NM_007232) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HRH3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HRH3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRH3 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004969 | histamine receptor activity |
IEA | -- |
HRH3 for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for HRH3: Hrh3tm1Kot Hrh3tm1Twl Hrh3tm1.1Jhwa
7 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Hrh3):
HRH3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for HRH3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Signaling by GPCR | | | 3 | Histamine receptors | | | 4 | Monoamine Transport | | | 5 | Monoamine GPCRs | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for HRH3
5/8 
Reactome Pathways for HRH3 (see all 8)
1 
Kegg Pathway (Kegg details for HRH3):
HRH3 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HRH3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/144 Interacting proteins for HRH3 (Q9Y5N13 ENSP000003425604) via UniProtKB, MINT, STRING, and/or I2D (see all 144)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007187 | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
TAS | 10347254 | | GO:0007269 | neurotransmitter secretion |
TAS | 10347254 |
HRH3 for ontologies About GeneDecksing
|
Drugs & Compounds
for HRH3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
HRH3 for compounds About GeneDecksing
Compounds for HRH3 available from Tocris Bioscience About this table
2 HMDB Compounds for HRH3 About this table
2 DrugBank Compounds for HRH3 About this table
10/28 Novoseek chemical compound relationships for HRH3 gene (see all 28) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| thioperamide |
94.4 |
9 |
8564266 (2), 9640366 (1), 9455995 (1), 15544557 (1) (see all 7) |
| imetit |
93.6 |
3 |
9865516 (1), 9455995 (1), 16532454 (1) |
| clobenpropit |
89.3 |
2 |
14729385 (1), 15997873 (1) |
| immepip |
86.6 |
5 |
16297617 (2), 9185835 (1), 16532454 (1), 8308858 (1) |
| histamine |
86.4 |
98 |
7867658 (3), 9699219 (3), 8448069 (2), 10516658 (2) (see all 69) |
| alpha methylhistamine |
86.1 |
2 |
7698611 (1), 9793613 (1) |
| iodophenpropit |
79.8 |
7 |
8564266 (3) |
| tele-methylhistamine |
75.5 |
3 |
10755377 (1), 12971961 (1) |
| chlorpheniramine |
68.7 |
2 |
9455995 (1), 8809785 (1) |
| mepyramine |
65.5 |
1 |
8564521 (1) |
Search CenterWatch for drugs/clinical trials and news about HRH3
|
Transcripts
for HRH3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HRH3 gene: NM_007232.2 Unigene Cluster for HRH3: Histamine receptor H3 Hs.251399 [show with all ESTs]Unigene Representative Sequence: AF1405382 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000340177(uc002ycf.2) ENST00000317393(uc002ych.3 uc002ycg.3 uc002yci.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HRH3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HRH3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HRH3 (NM_007232) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HRH3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HRH3 |
Additional cDNA sequence: AB019000.1 AF140538.1 AF321910.1 AF321911.1 AF321912.1 AF321913.1 AF346903.1 AF346904.1 AF363791.1 AK074730.1 BC096840.1 4 DOTS entries: DT.100750130 DT.438395 DT.100020634 DT.91731029 23 AceView cDNA sequences: AF363791 AB019000 CB154982 BQ068856 NM_007232 BM548665 BF531112 AK074730 AF321910 AF321913 BX089742 AF140538 AF346904 AF321911 AF346903 CF147822 AF321912 AB045369 H30846 BE783826 R87218 R87217 H28163
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for HRH3 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b |
|---|
|
| SP1: | | | - | | | | | | | | | | | | |
| SP2: | | | - | | | | | | | | - | | | | |
| SP3: | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for HRH3
|
Expression
for HRH3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HRH3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCCTCTGCC
About this image
See HRH3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HRH3
SOURCE GeneReport for Unigene cluster: Hs.251399
UniProtKB/Swiss-Prot: HRH3_HUMAN, Q9Y5N1Tissue specificity: Expressed predominantly in the CNS, with the greatest expression in the thalamus and caudatenucleus. The various isoforms are mainly coexpressed in brain, but their relative expression level varies in aregion-specific manner. Isoform 3 and isoform 7 are highly expressed in the thalamus, caudate nucleus and cerebellumwhile isoform 5 and isoform 6 show a poor expression. Isoform 5 and isoform 6 show a high expression in the amygdala,substantia nigra, cerebral cortex and hypothalamus. Isoform 7 is not found in hypothalamus or substantia nigra
SABiosciences Expression via Pathway-Focused PCR Array including HRH3:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HRH3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HRH3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HRH3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HRH3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRH3 |
Orthologs
for HRH3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for HRH3 gene from 5/13 species (see all 13) About this table
ENSEMBL Gene Tree for HRH3 (if available)
TreeFam Gene Tree for HRH3 (if available) |
Paralogs
for HRH3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HRH3 gene
- HRH42 CHRM52 HRH12 CHRM12 CHRM22 CHRM42 CHRM32
18/19 SIMAP similar genes for HRH3 using alignment to 7 protein entries: HRH3_HUMAN (see all proteins)
(see all similar genes):DRD2 ADRA1A CHRM5 H4 HTR7 ADRB2
DRD1 HRH4 DRD3 CHRM3 CHRM1 ADRA2B
CHRM2 HTR5A CHRM4 ADRB1 ADRA2C ADRB3
HRH3 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for HRH3
PGOHUM00000259137
|
Genomic Variants
for HRH3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HRH3 (60790017 - 60795323 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for HRH3
2 CNVs: 5347 30129
Human Gene Mutation Database (HGMD): HRH3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HRH3 |
|
Disorders
/ Diseases
for HRH3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HRH3 for disorders About GeneDecksing
OMIM gene information: 604525
OMIM disorders: --
20/24  diseases for HRH3 (see all 24): About MalaCardsattention deficit hyperactivity disorder seizures neuronitis sleep disorder
chorea brain disease hepatic coma parkinson's disease
migraine alzheimer's disease dementia ischemia
asthma obesity pertussis pancreatic carcinoma
schizophrenia cholangiocarcinoma pancreatitis hepatitis
2 diseases from the University of Copenhagen DISEASES database for HRH3:Attention deficit hyperactivity disorder Schizophrenia 10/16 Novoseek disease relationships for HRH3 gene (see all 16) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cognitive disorder |
68 |
6 |
18469850 (1), 19429511 (1), 15608078 (1), 16565470 (1) (see all 6) |
| cns diseases |
40.5 |
3 |
14529362 (1), 19429511 (1), 19222483 (1) |
| attention-deficit hyperactivity disorder |
36.7 |
1 |
15219708 (1) |
| schizophrenia |
35.7 |
6 |
19413576 (3), 15608077 (1), 15219708 (1), 16364652 (1) |
| catalepsy |
25.1 |
1 |
15910772 (1) |
| alzheimers disease |
23.9 |
5 |
19222483 (2), 15219708 (1), 17327487 (1), 10511950 (1) |
| migraine |
21.8 |
1 |
18942262 (1) |
| parkinson disease |
19 |
6 |
16532454 (3), 10051746 (1), 10511950 (1), 16738217 (1) |
| brain diseases |
18.8 |
2 |
17327487 (1), 19222483 (1) |
| obesity |
5.76 |
2 |
16565470 (1), 18221234 (1) |
Human Genome Epidemiology (HuGE) Navigator: HRH3 (6 documents)
Export disorders for HRH3 gene to outside databases
|
Publications
for HRH3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HRH3 gene, integrated from 9 sources (see all 188):
(articles sorted by number of sources associating them with HRH3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and functional expression of the human histamine H3 receptor. (PubMed id 10347254)1, 2, 3, 9 Lovenberg T.W.... Erlander M.G. (1999)
- Molecular cloning and characterization of a new human histamine receptor, HH4R. (PubMed id 11118334)1, 2, 9 Nakamura T.... Tanaka K. (2000)
- Structure of the human histamine H3 receptor gene (HRH3) and identification of naturally occurring variations. (PubMed id 11956964)1, 2, 9 Wiedemann P.... Bruess M. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Genomic organization and characterization of splice variants of the human histamine H3 receptor. (PubMed id 11284713)1, 2 Coge F.... Galizzi J.-P. (2001)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Altered histamine H3 receptor radioligand binding in post-mortem brain samples from subjects with psychiatric diseases. (PubMed id 19413576)1, 9 Jin C.Y....Panula P. (2009)
- Marked changes in signal transduction upon heteromerization of dopamine D1 and histamine H3 receptors. (PubMed id 19413572)1, 9 Ferrada C....Franco R. (2009)
- Histamine H3 receptors--general characterization and their function in the cardiovascular system. (PubMed id 9670104)1, 9 Malinowska B....Schlicker E. (1998)
- Molecular modeling of histamine H3 receptor and QSAR studies on arylbenzofuran derived H3 antagonists. (PubMed id 17561422)1, 9 Dastmalchi S....Hamzeiy H. (2008)
|
External Searches for HRH3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HRH3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HRH3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HRH3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HRH3 | Pharmacogenomics, SNPs, Pathways |
|
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About This Section
| Patent Information for HRH3 gene:
Search GeneIP for patents involving HRH3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for HRH3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for HRH3 | | OriGene shRNA RFP for HRH3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HRH3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HRH3 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HRH3 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HRH3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HRH3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HRH3 | | OriGene Custom Protein Services for HRH3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HRH3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HRH3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HRH3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HRH3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HRH3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HRH3 |
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| | | | Tocris compounds for HRH3 |
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 | | | HRH3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRH3 |
|  |  |  | | | | ThermoFisher Antibodies for HRH3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HRH3 |
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