Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HRH3 Gene

protein-coding   GIFtS: 64
GCID: GC20M060790

Histamine Receptor H3

  See HRH3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Histamine Receptor H31 2     G-Protein Coupled Receptor 972 3
GPCR972 3 5     G Protein-Coupled Receptor 972
H3R2 3     Histamine H3 Receptor2
HH3R2 3     

External Ids:    HGNC: 51841   Entrez Gene: 112552   Ensembl: ENSG000001011807   OMIM: 6045255   UniProtKB: Q9Y5N13   

Export aliases for HRH3 gene to outside databases

Previous GC identifers: GC20M060553 GC20M061428 GC20M061475 GC20M060223 GC20M057566


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for HRH3 Gene:
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons.
Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine
receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein
and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in
smooth muscles and innervates the blood vessels and the heart in cardiovascular system. (provided by RefSeq, Jul
2008)

GeneCards Summary for HRH3 Gene:
HRH3 (histamine receptor H3) is a protein-coding gene. Diseases associated with HRH3 include hepatic coma, and sleep disorder. GO annotations related to this gene include histamine receptor activity. An important paralog of this gene is HTR2A.

UniProtKB/Swiss-Prot: HRH3_HUMAN, Q9Y5N1
Function: The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous
system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous
activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity
nor induced intracellular calcium mobilization

summary for HRH3 Gene:
Histamine H3 receptors are Galphai/o-protein-coupled receptors first cloned in 1999. H3 receptors are
expressed at high levels on histaminergic neurons in the central nervous system, particularly in the basal
ganglia, cortex, hippocampus and strial area. They are expressed in the periphery at lower densities in the
gastrointestinal, bronchial and cardiovascular systems. H3 receptors are thought to function as presynaptic
autoreceptors, and activation stimulates the negative feedback mechanism that reduces central histaminergic
activity. These receptors have displayed heterogeneity in binding and functional studies, suggesting
multiple subtypes. In rats, three H3 receptor subtypes have been indentified and they all vary in the length
of the third extracellular loop, have distinct CNS localization and differentially couple to adenylyl
cyclase and MAPK signaling pathways. H3 receptors have multiple functions including roles in cognition,
sleep-wake status, energy homeostasis regulation and inflammation. Activation of these receptors can inhibit
histamine, dopamine, serotonin, noradrenalin and acetylcholine release and they participate in control of
neurogenic inflammation through local-neuron feedback loops. Furthermore, H3 receptor activation increases
antigen-presenting cell capacity. H3 receptors are thought to have pathophysiological relevance and are
involved in cognitive impairment, seizures and possibly metabolic syndrome. The human gene encoding this
receptor is localized to chromosome 20q13.33.

Gene Wiki entry for HRH3 (Histamine H3 receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HRH3 gene promoter:
         ER-alpha   USF1   Spz1   HTF   Olf-1   C/EBPalpha   Arnt   CBF-A   USF-1   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHRH3 promoter sequence
   Search Chromatin IP Primers for HRH3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HRH3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.33   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.33

HRH3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HRH3 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M060790:  view genomic region     (about GC identifiers)

Start:
60,790,017 bp from pter      End:
60,795,323 bp from pter
Size:
5,307 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: HRH3_HUMAN, Q9Y5N1 (See protein sequence)
Recommended Name: Histamine H3 receptor  
Size: 445 amino acids; 48671 Da
Miscellaneous: Does not bind to cimetidine and tripolidine. Shows modest affinity for thioperamide, imetit,
N-alpha-methylhistamine and R(-)-alpha-methylhistamine. Isoform 4 is unable to bind to iodoproxyfan while
isoforms 1 and 3 bind it with high affinity
Secondary accessions: Q4QRI7 Q9GZX2 Q9H4K8
Alternative splicing: 7 isoforms:  Q9Y5N1-1   Q9Y5N1-2   Q9Y5N1-3   Q9Y5N1-4   Q9Y5N1-5   Q9Y5N1-6   Q9Y5N1-7   

Explore the universe of human proteins at neXtProt for HRH3: NX_Q9Y5N1

Explore proteomics data for HRH3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn11
  • Modification sites at PhosphoSitePlus

  • See HRH3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009163.2  
    ENSEMBL proteins: 
     ENSP00000342560   ENSP00000321482  
    Reactome Protein details: Q9Y5N1

    HRH3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for HRH3
    GenScript Custom Purified and Recombinant Proteins Services for HRH3
    Novus Biologicals HRH3 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HRH3

     
    Search eBioscience for Proteins for HRH3 

    HRH3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HRH3
    Browse R&D Systems for Antibodies
    OriGene Antibodies for HRH3
    OriGene Custom Antibody Services for HRH3
    Novus Biologicals HRH3 Antibodies
    Abcam antibodies for HRH3
    Cloud-Clone Corp. Antibodies for HRH3
    ThermoFisher Antibodies for HRH3
    LSBio Antibodies in human, mouse, rat for HRH3

    HRH3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HRH3
    Browse R&D Systems for biochemical assays
    GenScript HRH3-overexpressing Cell Line for Assay
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HRH3
    Cloud-Clone Corp. CLIAs for HRH3
    Search eBioscience for ELISAs for HRH3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    HRH: GPCR / Class A : Histamine receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: H3 receptor
    Histamine receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR003980 Histamine_H3_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q9Y5N1

    ProtoNet protein and cluster: Q9Y5N1

    1 Blocks protein domain: IPB003980 Histamine H3 receptor signature

    UniProtKB/Swiss-Prot: HRH3_HUMAN, Q9Y5N1
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with HRH3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HRH3_HUMAN, Q9Y5N1
    Function: The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous
    system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous
    activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity
    nor induced intracellular calcium mobilization

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004969histamine receptor activity IEA--
    GO:0008144drug binding IEA--
         
    Find genes that share ontologies with HRH3           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Hrh3):
     adipose tissue  behavior/neurological  cardiovascular system  growth/size/body  homeostasis/metabolism 
     immune system  nervous system 

    Find genes that share phenotypes with HRH3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for HRH3: Hrh3tm1Twl Hrh3tm1Kot Hrh3tm1.1Jhwa

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HRH3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HRH3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HRH3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HRH3

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat HRH3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HRH3 (see all 18):
    hsa-miR-3678-3p hsa-miR-1321 hsa-miR-29a hsa-miR-29c hsa-miR-765 hsa-miR-570 hsa-miR-298 hsa-miR-192*
    SwitchGear 3'UTR luciferase reporter plasmidHRH3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HRH3
    Predesigned siRNA for gene silencing in human, mouse, rat HRH3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HRH3

    Clone
    Products:
         
    OriGene clones in human, mouse for HRH3 (see all 5)
    OriGene ORF clones in mouse, rat for HRH3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HRH3 (NM_007232)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HRH3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HRH3

    Cell Line
    Products:
         
    GenScript HRH3-overexpressing Cell Line for Assay
    Browse ESI BIO Cell Lines and PureStem Progenitors for HRH3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRH3

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11070) for HRH3 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    HRH3_HUMAN, Q9Y5N1: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS10347254
    GO:0016021integral component of membrane ----
    GO:0043005neuron projection IEA--
    GO:0043209myelin sheath IEA--

    Find genes that share ontologies with HRH3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for HRH3 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    G alpha (i) signalling events0.44
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Monoamine GPCRs
    Amine ligand-binding receptors0.79
    Histamine receptors0.00
    4Monoamine Transport
    Monoamine Transport


    Find genes that share SuperPaths with HRH3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for HRH3
        Monoamine Transport
    GPCRs, Class A Rhodopsin-like

    2 Reactome Pathways for HRH3
        G alpha (i) signalling events
    Histamine receptors


    1 Kegg Pathway  (Kegg details for HRH3):
        Neuroactive ligand-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Array including HRH3: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for HRH3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HRH3 (Q9Y5N13 ENSP000003425604) via UniProtKB, MINT, STRING, and/or I2D (see all 145)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DRD1P217283I2D: score=1 
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY4ENSP000003121264STRING: ENSP00000312126
    ADCY8ENSP000002863554STRING: ENSP00000286355
    ADORA1ENSP000003085494STRING: ENSP00000308549
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS10347254
    GO:0007194negative regulation of adenylate cyclase activity IEA--
    GO:0007204positive regulation of cytosolic calcium ion concentration IEA--
    GO:0007269neurotransmitter secretion TAS10347254

    Find genes that share ontologies with HRH3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for HRH3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    (R)-(-)-alpha-Methylhistamine dihydrobromide Potent, standard H3 agonist [75614-87-8]
    ThioperamideH3 antagonist and H4 inverse agonist[106243-16-7]
    Clobenpropit dihydrobromideHighly potent H3 antagonist and H4 partial agonist[145231-45-4]
    Immepip dihydrobromideStandard H3 agonist. Also H4 agonist[164391-47-3]
    BF 2649 hydrochlorideH3 receptor inverse agonist/antagonist[903576-44-3]

    2 HMDB Compounds for HRH3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Histamine1H-Imidazole-4-ethanamine (see all 27)51-45-6--

    2 DrugBank Compounds for HRH3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Histamine Phosphate-- 51-74-1targetagonist17652997 16715497 17575572 16599255
    Betahistine-- 5638-76-6targetantagonist18447604 11700150 20530654

    Selected IUPHAR Ligands for HRH3 (H3 receptor) (see all 38)    About this table
    LigandTypeActionAffinityPubmed IDs
    [123I]iodoproxyfan
    AntagonistAntagonist10.211090094
    iodoproxyfan
    AgonistFull agonist1012393057
    immepip
    AgonistFull agonist8.8 - 9.710869375 12393057 11179434 14640553 11284713
    imetit
    AgonistFull agonist8.8 - 9.710869375 12393057 11179434 11714875 11284713
    ABT-239
    AntagonistInverse agonist9.415608078
    clobenpropit
    AntagonistAntagonist8.4 - 9.410869375 12393057 11179434 12606603 11714875 11090094 11284713
    A-349821
    AntagonistInverse agonist9.415294456
    N-methylhistamine
    AgonistFull agonist8.6 - 9.310869375 11179434 11284713
    (R)-alpha-methylhistamine
    AgonistFull agonist8.4 - 9.210869375 12393057 11179434 11714875 11090094 11284713
    1-[4-(3-piperidin-1-ylpropoxy)benzyl]piperidine
    AntagonistAntagonist9.212930154

    Selected Novoseek inferred chemical compound relationships for HRH3 gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thioperamide 94.4 9 8564266 (2), 9640366 (1), 9455995 (1), 15544557 (1) (see all 7)
    imetit 93.6 3 9865516 (1), 9455995 (1), 16532454 (1)
    clobenpropit 89.3 2 14729385 (1), 15997873 (1)
    immepip 86.6 5 16297617 (2), 9185835 (1), 16532454 (1), 8308858 (1)
    histamine 86.4 98 7867658 (3), 9699219 (3), 8448069 (2), 10516658 (2) (see all 69)
    alpha methylhistamine 86.1 2 7698611 (1), 9793613 (1)
    iodophenpropit 79.8 7 8564266 (3)
    tele-methylhistamine 75.5 3 10755377 (1), 12971961 (1)
    chlorpheniramine 68.7 2 9455995 (1), 8809785 (1)
    mepyramine 65.5 1 8564521 (1)



    Find genes that share compounds with HRH3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for HRH3 gene: 
    NM_007232.2  

    Unigene Cluster for HRH3:

    Histamine receptor H3
    Hs.251399  [show with all ESTs]
    Unigene Representative Sequence: AF140538
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000340177(uc002ycf.2) ENST00000317393(uc002ych.3 uc002ycg.3 uc002yci.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HRH3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HRH3 (see all 18):
    hsa-miR-3678-3p hsa-miR-1321 hsa-miR-29a hsa-miR-29c hsa-miR-765 hsa-miR-570 hsa-miR-298 hsa-miR-192*
    SwitchGear 3'UTR luciferase reporter plasmidHRH3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HRH3
    Predesigned siRNA for gene silencing in human, mouse, rat HRH3
    Clone
    Products:
         
    OriGene clones in human, mouse for HRH3 (see all 5)
    OriGene ORF clones in mouse, rat for HRH3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HRH3 (NM_007232)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HRH3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HRH3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HRH3
    OriGene qSTAR qPCR primer pairs in human, mouse for HRH3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HRH3
      QuantiTect SYBR Green Assays in human, mouse, rat HRH3
      QuantiFast Probe-based Assays in human, mouse, rat HRH3
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11070) for HRH3 

    Additional mRNA sequence: 

    AB019000.1 AF140538.1 AF321910.1 AF321911.1 AF321912.1 AF321913.1 AF346903.1 AF346904.1 
    AF363791.1 AK074730.1 BC096840.1 

    4 DOTS entries:

    DT.100750130  DT.438395  DT.100020634  DT.91731029 

    23 AceView cDNA sequences:

    CB154982 BQ068856 AB019000 AF363791 AK074730 AF346904 AF321911 NM_007232 
    AF321910 AF346903 BX089742 CF147822 BM548665 AF321912 AF321913 AF140538 
    BF531112 AB045369 H30846 BE783826 R87218 R87217 H28163 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for HRH3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
    SP1:        -                                 
    SP2:        -                       -         
    SP3:        -                                 
    SP4:                                          


    ECgene alternative splicing isoforms for HRH3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    HRH3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCCTCTGCC
    HRH3 Expression
    About this image

    HRH3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HRH3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.251399

    UniProtKB/Swiss-Prot: HRH3_HUMAN, Q9Y5N1
    Tissue specificity: Expressed predominantly in the CNS, with the greatest expression in the thalamus and caudate
    nucleus. The various isoforms are mainly coexpressed in brain, but their relative expression level varies in a
    region-specific manner. Isoform 3 and isoform 7 are highly expressed in the thalamus, caudate nucleus and
    cerebellum while isoform 5 and isoform 6 show a poor expression. Isoform 5 and isoform 6 show a high expression
    in the amygdala, substantia nigra, cerebral cortex and hypothalamus. Isoform 7 is not found in hypothalamus or
    substantia nigra

        Pathway & Disease-focused RT2 Profiler PCR Array including HRH3: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HRH3
    OriGene qSTAR qPCR primer pairs in human, mouse for HRH3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HRH3
    QuantiTect SYBR Green Assays in human, mouse, rat HRH3
    QuantiFast Probe-based Assays in human, mouse, rat HRH3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRH3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for HRH3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hrh31 , 5 histamine receptor H31, 5 87.49(n)1
    92.36(a)1
      2 (102.62 cM)5
    992961  NM_133849.31  NP_598610.11 
     1723947085 
    chicken
    (Gallus gallus)
    Aves HRH31 histamine receptor H3 69.88(n)
    74.48(a)
      428147  XM_004947083.1  XP_004947140.1 
    lizard
    (Anolis carolinensis)
    Reptilia HRH36
    histamine receptor H3
    66(a)
    1 ↔ 1
    4(150769383-150800052)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.42532 Transcribed sequence with moderate similarity to protein more 74.05(n)    AL848045.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003349621 histamine H3 receptor-like 69.4(n)
    74.02(a)
      100334962  XM_003200921.2  XP_003200969.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG79186
    --
    12(a)
    1 → many
    3R(3885006-3912767)
    worm
    (Caenorhabditis elegans)
    Secernentea gar-26
    gar-16
    Protein GAR-2, isoform d
    Protein GAR-1, isoform c (gar-1) mRNA, complete cd...
    15(a)
    13(a)
    many ↔ many
    many ↔ many
    III(6309378-6320871) WBGene00001518
    X(6479638-6484810) WBGene00001517


    ENSEMBL Gene Tree for HRH3 (if available)
    TreeFam Gene Tree for HRH3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for HRH3 gene
    HTR2A2  DRD42  DRD22  CHRM12  CHRM22  HTR2B2  HRH42  HTR2C2  
    HRH12  CHRM52  DRD32  CHRM42  CHRM32  
    17 SIMAP similar genes for HRH3 using alignment to 7 protein entries:     HRH3_HUMAN (see all proteins):
    DRD2    ADRA1A    CHRM5    H4    HTR7    ADRB2
    DRD1    HRH4    DRD3    CHRM3    CHRM1    ADRA2B
    CHRM2    HTR5A    CHRM4    ADRB1    ADRA2C

    Find genes that share paralogs with HRH3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for HRH3
    PGOHUM00000259137


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for HRH3 (see all 259)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1454625181,2
    --60789745(+) CAGAGC/TGGGCC 1 -- ds50010--------
    rs1893001221,2
    C--60789867(+) TGGCAG/TGCTGG 1 -- ds50010--------
    rs17395851,2
    C,F,H--60790056(-) GCAAAC/ACGTGA 1 -- ut31 ese39Minor allele frequency- A:0.02MN NS NA WA 1180
    rs1821411441,2
    C--60790105(+) GCGCGC/TGGCAC 1 -- ut310--------
    rs1996548711,2
    C--60790352(+) AGGGCA/GTGGGA 1 -- ut310--------
    rs2007918101,2
    C,F--60790460(+) TCATCT/CTTCTG 1 -- ut311Minor allele frequency- C:0.01EU 593
    rs1873846411,2
    C--60790626(+) TTGTCC/TGGGGA 1 -- ut310--------
    rs1892413741,2
    C--60790644(+) GGTGTA/GCAGGT 1 -- ut310--------
    rs2011153201,2
    C--60790781(+) AGGGGA/GTGGGC 1 -- ut310--------
    rs1815509291,2
    C--60790982(+) CGAGCC/TGGGTA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for HRH3 (60790017 - 60795323 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for HRH3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422398CNV Duplication17116639
    dgv4598n71CNV Loss21882294
    nsv913040CNV Loss21882294
    nsv913047CNV Loss21882294
    dgv4597n71CNV Loss21882294
    nsv518296CNV Loss19592680
    dgv4599n71CNV Loss21882294
    nsv470556CNV Loss18288195
    dgv4600n71CNV Loss21882294
    dgv4601n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): HRH3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HRH3
    DNA2.0 Custom Variant and Variant Library Synthesis for HRH3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604525    OMIM disorders: --

    4 diseases for HRH3:    
    About MalaCards
    hepatic coma    sleep disorder    attention deficit hyperactivity disorder    schizophrenia

    2 diseases from the University of Copenhagen DISEASES database for HRH3:
    Attention deficit hyperactivity disorder     Schizophrenia

    Find genes that share disorders with HRH3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for HRH3 gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cognitive disorder 68 6 18469850 (1), 19429511 (1), 15608078 (1), 16565470 (1) (see all 6)
    cns diseases 40.5 3 14529362 (1), 19429511 (1), 19222483 (1)
    attention-deficit hyperactivity disorder 36.7 1 15219708 (1)
    schizophrenia 35.7 6 19413576 (3), 15608077 (1), 15219708 (1), 16364652 (1)
    catalepsy 25.1 1 15910772 (1)
    alzheimers disease 23.9 5 19222483 (2), 15219708 (1), 17327487 (1), 10511950 (1)
    migraine 21.8 1 18942262 (1)
    parkinson disease 19 6 16532454 (3), 10051746 (1), 10511950 (1), 16738217 (1)
    brain diseases 18.8 2 17327487 (1), 19222483 (1)
    obesity 5.76 2 16565470 (1), 18221234 (1)

    Genetic Association Database (GAD): HRH3
    Human Genome Epidemiology (HuGE) Navigator: HRH3 (6 documents)

    Export disorders for HRH3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for HRH3 gene, integrated from 10 sources (see all 192):
    (articles sorted by number of sources associating them with HRH3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional expression of the human histamine H3 receptor. (PubMed id 10347254)1, 2, 3, 9 Lovenberg T.W.... Erlander M.G. (Mol. Pharmacol. 1999)
    2. Molecular cloning and characterization of a new human histamine receptor, HH4R. (PubMed id 11118334)1, 2, 9 Nakamura T.... Tanaka K. (Biochem. Biophys. Res. Commun. 2000)
    3. Structure of the human histamine H3 receptor gene (HRH3) and identification of naturally occurring variations. (PubMed id 11956964)1, 2, 9 Wiedemann P.... Bruess M. (J. Neural Transm. 2002)
    4. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (Pharmacogenomics 2010)
    5. Association and interaction analyses of eight genes under asthma linkage peaks. (PubMed id 19824886)1, 4 Ferreira M.A....Duffy D.L. (Allergy 2009)
    6. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (Eur. J. Hum. Genet. 2009)
    7. Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. (PubMed id 18996102)1, 4 RuaA+o G....Hanks S. ( international journal of clinical chemistry 2009)
    8. Multiple genetic factors in olanzapine-induced weight gain in schizophrenia patients: a cohort study. (PubMed id 19193342)1, 4 Ujike H....Kuroda S. (J Clin Psychiatry 2008)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Genomic organization and characterization of splice variants of the human histamine H3 receptor. (PubMed id 11284713)1, 2 Coge F.... Galizzi J.-P. (Biochem. J. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 11255 HGNC: 5184 AceView: HRH3 Ensembl:ENSG00000101180 euGenes: HUgn11255
    ECgene: HRH3 Kegg: 11255 H-InvDB: HRH3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for HRH3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for HRH3 gene:
    Search GeneIP for patents involving HRH3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of HRH3
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     cDNA Clones for HRH3 (Histamine H3 R)   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for HRH3   OriGene RNAi products in human, mouse, rat for HRH3  
     OriGene qPCR primer pairs and template standards for HRH3   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for HRH3  
     OriGene qSTAR qPCR primer pairs in human, mouse for HRH3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for HRH3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HRH3   OriGene Custom Protein Services for HRH3  

     
     
     Block miRNA regulation of human, mouse, rat HRH3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HRH3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HRH3 Predesigned siRNA for gene silencing in human, mouse, rat HRH3
     QuantiFast Probe-based Assays in human, mouse, rat HRH3 QuantiTect SYBR Green Assays in human, mouse, rat HRH3
     PCR Arrays including human, mouse, rat HRH3 Search Chromatin IP Primers for HRH3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HRH3  Search GeneGlobe Interaction Network for HRH3
     Regulatory tfbs in HRH3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for HRH3 GenScript cDNA clones with any tag delivered in your preferred vector for HRH3
     GenScript HRH3-overexpressing Cell Line for Assay CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for HRH3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     HRH3 antibodies
     HRH3 proteins
     Antibodies for HRH3
     See all of Abcam's Antibodies, Kits and Proteins for HRH3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for HRH3
     Antibodies for HRH3
     ELISAs for HRH3
     CLIAs for HRH3



     Browse ESI BIO Cell Lines and PureStem Progenitors for HRH3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRH3
     SwitchGear 3'UTR luciferase reporter plasmids for HRH3
     SwitchGear Promoter luciferase reporter plasmids for HRH3
     ThermoFisher Antibodies for HRH3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HRH3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HRH3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HRH3
     LSBio Antibodies in human, mouse, rat for HRH3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for HRH3
      Search eBioscience for proteins for HRH3
      Search eBioscience for elisas for HRH3
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HRH3 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4