HRH3 Gene(Protein Coding)

Histamine Receptor H3

GCID:: GC20M062214

GIFtS:: 50

Genes Participants

Aliases for HRH3 Gene

Histamine Receptor H3 ² ³ ⁵
GPCR97 ³ ⁴
HH3R ³ ⁴
H3R ³ ⁴
G Protein-Coupled Receptor 97 ³
G-Protein Coupled Receptor 97 ⁴
Histamine H3 Receptor ³

External Ids for HRH3 Gene

HGNC: 5184
Entrez Gene: 11255
Ensembl: ENSG00000101180
OMIM: 604525
UniProtKB: Q9Y5N1

Previous GeneCards Identifiers for HRH3 Gene

GC20M060553
GC20M061428
GC20M061475
GC20M060223
GC20M060790
GC20M057566

Search aliases for HRH3 gene in PubMed and other databases

Summaries for HRH3 Gene

Entrez Gene Summary for HRH3 Gene

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smooth muscles and innervates the blood vessels and the heart in cardiovascular system. [provided by RefSeq, Jul 2008]

GeneCards Summary for HRH3 Gene

HRH3 (Histamine Receptor H3) is a Protein Coding gene. Diseases associated with HRH3 include Hepatic Coma and Kleine-Levin Hibernation Syndrome. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and histamine receptor activity. An important paralog of this gene is HRH4.

UniProtKB/Swiss-Prot for HRH3 Gene

HRH3_HUMAN,Q9Y5N1

The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.

Tocris Summary for HRH3 Gene

Histamine H3 receptors are Galphai/o-protein-coupled receptors expressed at high levels on histaminergic neurons in the CNS, particularly in the basal ganglia, cortex and hippocampus. H3 receptors are thought to function as presynaptic autoreceptors.

Gene Wiki entry for HRH3 Gene

Additional gene information for HRH3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HRH3 Gene

Genomics for HRH3 Gene

GeneHancer (GH) Regulatory Elements for HRH3 Gene

Promoters and enhancers for HRH3 Gene

GeneHancer (GH) Identifier	GH Type	GH Score	GH Sources	Gene Association Score	Total Score	TSS distance (kb)	Number of Genes Away	Size (kb)	Transcription Factor Binding Sites
GH20I062220	Promoter/Enhancer	1.8	EPDnew Ensembl ENCODE	550.8	+0.0	31	0.5	HDAC1 NFIB ARID4B SIN3A DNMT3B ZNF48 ZSCAN9 RARA SLC30A9 ZNF766	HRH3 PIR52239
GH20I062245	Enhancer	0.9	ENCODE dbSUPER	12.3	-26.5	-26495	1.7	SOX13 MXI1 SAP130 ZNF449 ZFP64 ARID4B MAX RARA TEAD3 SCRT2	HRH3 LAMA5-AS1 MTG2 ENSG00000226332 OSBPL2 GC20M062290
GH20I062186	Enhancer	0.8	Ensembl ENCODE	11.7	+32.8	32790	1.4	SCRT1 HLF CBFA2T3 PAX8 EGR1 SCRT2 IKZF1 SPI1	SS18L1 PSMA7 HRH3 MTG2 PIR52239
GH20I062240	Enhancer	0.7	Ensembl ENCODE	12.7	-21.9	-21858	2.6	SIN3A ELF1 ZBTB33 KDM1A NFE2 NR2F2	HRH3 OSBPL2 LAMA5-AS1 GC20M062290
GH20I062010	Enhancer	0.8	ENCODE	10.6	+209.2	209248	0.2	ELF3 ARID4B SIN3A DMAP1 ZNF48 RAD21 ARID2 SMARCA5 ZNF654 USF2	PSMA7 SS18L1 HRH3 CDH4 LOC105372704 GC20M062040 TAF4

- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HRH3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HRH3 gene promoter:

Regulatory Element Products

Genomic Locations for HRH3 Gene

chr20:62,214,766-62,220,278: (GRCh38/hg38)

Size:: 5,513 bases
Orientation:: Minus strand

chr20:60,790,017-60,795,323: (GRCh37/hg19)

Genomic View for HRH3 Gene

Genes around HRH3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:

20q13.33 by Ensembl
20q13.33 by Entrez Gene
20q13.33 by HGNC

HRH3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

Genomic Location for HRH3 Gene — Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for HRH3 Gene

Proteins for HRH3 Gene

Protein details for HRH3 Gene (UniProtKB/Swiss-Prot)
Protein Symbol:

Q9Y5N1-HRH3_HUMAN

Recommended name:

Histamine H3 receptor

Protein Accession:

Q9Y5N1

Secondary Accessions:
- Q4QRI7
- Q9GZX2
- Q9H4K8
Protein attributes for HRH3 Gene
Size:

445 amino acids

Molecular mass:

48671 Da
Quaternary structure:

No Data Available

Miscellaneous:
Does not bind to cimetidine and tripolidine. Shows modest affinity for thioperamide, imetit, N-alpha-methylhistamine and R(-)-alpha-methylhistamine. Isoform 4 is unable to bind to iodoproxyfan while isoforms 1 and 3 bind it with high affinity.
Alternative splice isoforms for HRH3 Gene
UniProtKB/Swiss-Prot:
Q9Y5N1-1

Q9Y5N1-2

Q9Y5N1-3

Q9Y5N1-4

Q9Y5N1-5

Q9Y5N1-6

Q9Y5N1-7

neXtProt entry for HRH3 Gene

Post-translational modifications for HRH3 Gene

Glycosylation at posLast=1111
- NX_Q9Y5N1

Other Protein References for HRH3 Gene

ENSEMBL proteins:

REFSEQ proteins:

Antibody Products

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OriGene Antibodies for HRH3
- AP01216PU-N
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- TA308494
- TA308704
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- TA317574
- TA351265
- TA343198
- TA343197
- TA317598
- TA317575
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Novus Biologicals Antibodies for HRH3

Abcam antibodies for HRH3
- HRH3

Browse Antibodies at Cloud-Clone Corp.

Invitrogen Antibodies for HRH3

GeneTex HRH3 antibody for HRH3

Santa Cruz Biotechnology (SCBT) Antibodies for HRH3
- Histamine H3 Receptor (D-5)

Browse Sino Biological Antibodies

Protein Products

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Origene Custom Protein Services for HRH3

GenScript Custom Purified and Recombinant Proteins Services for HRH3

Novus Biologicals proteins for HRH3

Browse ProSpec Recombinant Proteins

Browse Proteins at Cloud-Clone Corp.

antibodies-online: Search results for 5 available HRH3 Proteins ranked by validation data
Compare Top HRH3 Proteins

Search GeneTex for Proteins for HRH3

Search for HRH3 Proteins at ProSci

Abcam proteins for HRH3
- HRH3

Assay Products

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GenScript Activity-based Kinase Assay for Compound Screening for HRH3
GenScript Custom Assay Services for HRH3

Browse Assay Kits at Cloud-Clone Corp.

antibodies-online: Search results for 4 available HRH3 Elisa Kits ranked by validation data
Compare Top HRH3 Elisa Kits
Recommended
- 4 Rat (Rattus) ELISA Kits

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No data available for DME Specific Peptides for HRH3 Gene

Domains & Families for HRH3 Gene

Gene Families for HRH3 Gene

HGNC:

187 : Histamine receptors

IUPHAR :

Human Protein Atlas (HPA):

FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins

Protein Domains for HRH3 Gene

InterPro:

Blocks:

Histamine H3 receptor signature

ProtoNet:

Q9Y5N1

Suggested Antigen Peptide Sequences for HRH3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y5N1

UniProtKB/Swiss-Prot:

HRH3_HUMAN :

Belongs to the G-protein coupled receptor 1 family.

Family:

Belongs to the G-protein coupled receptor 1 family.

Function for HRH3 Gene

Molecular function for HRH3 Gene

UniProtKB/Swiss-Prot Function:

The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.

HRH3_HUMAN,Q9Y5N1

Gene Ontology (GO) - Molecular Function for HRH3 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004871	signal transducer activity	IEA	--
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0004969	histamine receptor activity	IBA,IEA	--

Phenotypes for HRH3 Gene

MGI mutant phenotypes for HRH3:

inferred from 6 alleles

GenomeRNAi human phenotypes for HRH3:

Animal Models for HRH3 Gene

MGI Knock Outs for HRH3:

Hrh3 ^tm1Twl
Hrh3 ^tm1Kot
Hrh3 ^tm1.1Jhwa

Addgene plasmids for HRH3

genomics-online: cdna clones - Search results for available HRH3 gene related products
orf clones - Search results for available HRH3 gene related products

ProteoGenix Custom Cloning/Gene Synthesis Service (Subcloning and Mutagenesis/Gene Library Synthesis)

Applied Biological Materials Clones for HRH3
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- HRH3

R&D Systems cDNA Clones for HRH3 (Histamine H3 R)

Cell Line Products

GenScript HRH3 - overexpressing Cell Line for Assay
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Horizon Cell Lines for HRH3
- HRH3 knockout cell line

ViGene Biosciences adenoviral particle packaged cDNA for HRH3 gene
- VH800147
ViGene Biosciences lentiviral particle packaged cDNA for HRH3 gene
- LH800147
ViGene Biosciences ready-to-package AAV shRNAs for HRH3 gene
- SH800147

Cloud-Clone Corp. primary cells service

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for HRH3 Gene

Localization for HRH3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HRH3 Gene

Cell membrane; Multi-pass membrane protein.

Q9Y5N1-HRH3_HUMAN

Subcellular locations from

COMPARTMENTS

Compartment	Confidence
plasma membrane	5
nucleus	1

Gene Ontology (GO) - Cellular Components for HRH3 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral component of plasma membrane	TAS	10347254
GO:0016020	membrane	IEA	--
GO:0016021	integral component of membrane	IEA	--
GO:0045202	synapse	IEA	--

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HRH3 Gene

Pathways & Interactions for HRH3 Gene

SuperPathways for HRH3 Gene

More details on SuperPathways for HRH3

	SuperPathway	Contained pathways
1	Peptide ligand-binding receptors	Class A/1 (Rhodopsin-like receptors) .71 GPCR ligand binding .71 GPCRs, Class A Rhodopsin-like .42	G alpha (i) signalling events .42 Neuroactive ligand-receptor interaction .37
2	Signaling by GPCR	GPCR downstream signaling .76 Signaling by GPCR .76	Signal Transduction .52
3	Monoamine GPCRs	Amine ligand-binding receptors .75	Histamine receptors .01
4	Monoamine Transport	Monoamine Transport -

Pathways by source for HRH3 Gene

2 BioSystems pathways for HRH3 Gene

8 Reactome pathways for HRH3 Gene

1 KEGG pathway for HRH3 Gene

Neuroactive ligand-receptor interaction

Interacting Proteins for HRH3 Gene

http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000342560%0d%0a9606.ENSP00000312126%0d%0a9606.ENSP00000272644%0d%0a9606.ENSP00000332812%0d%0a9606.ENSP00000332225%0d%0a9606.ENSP00000255262%0d%0a — STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins: ENSP00000342560 Q9Y5N1-HRH3_HUMAN for HRH3 Gene via STRING IID

Symbol	External ID(s)	Details
ADCY1	ENSP00000297323 ²⁰ Q08828 ¹³⁷	STRING: ENSP00000297323 IID: # pred=1
ADRA2A	ENSP00000280155 ²⁰ P08913 ¹³⁷	STRING: ENSP00000280155 IID: # pred=1
ADRA2C	ENSP00000386069 ²⁰ P18825 ¹³⁷	STRING: ENSP00000386069 IID: # pred=1
GABBR2	ENSP00000259455 ²⁰ O75899 ¹³⁷	STRING: ENSP00000259455 IID: # pred=1
GRM2	ENSP00000378492 ²⁰ Q14416 ¹³⁷	STRING: ENSP00000378492 IID: # pred=1

Gene Ontology (GO) - Biological Process for HRH3 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	IEA	--
GO:0007186	G-protein coupled receptor signaling pathway	IEA,TAS	--
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	10347254
GO:0007194	negative regulation of adenylate cyclase activity	IBA	--
GO:0007269	neurotransmitter secretion	TAS	10347254

No data available for SIGNOR curated interactions for HRH3 Gene

Drugs & Compounds for HRH3 Gene

(101) Drugs for HRH3 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, and Novoseek

Name	Status	Disease Links	Group	Role	Mechanism of Action	Clinical Trials
Histamine	Approved, Investigational	MalaCards Medline Plus	Pharma	Full agonist, Agonist, Target, agonist		1105
Betahistine	Approved, Investigational	MalaCards Medline Plus	Pharma	Target, antagonist		16
Cimetidine	Approved, Investigational	MalaCards Medline Plus	Pharma	Inhibition, Inhibitor	H2 receptor antagonist	81
calcium	Approved	MalaCards Medline Plus	Nutra			0
Mirtazapine	Approved	MalaCards Medline Plus	Pharma	Target, antagonist		97

(18) Additional Compounds for HRH3 Gene - From: Novoseek, IUPHAR, and Tocris

Name	Role	CAS Number
(<i>R</i>)-alpha-methylhistamine	Full agonist, Agonist	MalaCards Medline Plus	10869375 11090094 11179434 11284713 11714875
(<i>S</i>)-alpha-methylhistamine	Full agonist, Agonist	MalaCards Medline Plus	12393057
[<sup>3</sup>H](<i>R</i>)-alpha-methylhistamine	Full agonist, Agonist	MalaCards Medline Plus	11179434
1-[4-(3-piperidin-1-ylpropoxy)benzyl]piperidine	Antagonist	MalaCards Medline Plus	12930154
4-(3-piperdin-1-yl-propoxy)benzonitrile	Antagonist	MalaCards Medline Plus	11179434

(5) Tocris Compounds for HRH3 Gene

Compound	Action	Cas Number
(R)-(-)-alpha-Methylhistamine dihydrobromide	Potent, standard H3 agonist	868698-49-1
(S)-(+)-alpha-Methylhistamine dihydrobromide	H3 agonist, less active enantiomer	75614-93-6
Imetit dihydrobromide	Standard H3 and H4 agonist (H3 > H4)	32385-58-3
Immepip dihydrobromide	Standard H3 agonist. Also H4 agonist	164391-47-3
Nalpha-Methylhistamine dihydrochloride	Non-selective H3 agonist	16503-22-3

(44) ApexBio Compounds for HRH3 Gene

Compound	Action	Cas Number
A 331440 dihydrochloride	H3 receptor antagonist,non-imidazole,high affinity	1049740-32-0
Astemizole		68844-77-9
Azatadine dimaleate		3978-86-7
Azelastine HCl		79307-93-0
Bavisant	Human H3 receptor antagonist	929622-08-2
Bavisant dihydrochloride	Human H3 receptor antagonist	929622-09-3
Bavisant dihydrochloride hydrate	Human H3 receptor antagonist	1103522-80-0
Benztropine mesylate		132-17-2
Bepotastine Besilate		190786-44-8
Betahistine 2HCl		5579-84-0
Brompheniramine hydrogen maleate		980-71-2
Buclizine HCl		129-74-8
Cetirizine	Antihistamine	83881-51-0
Cetirizine DiHCl	H1 receptor inverse agonist	83881-52-1
Chlorpheniramine Maleate		113-92-8
Cimetidine	H2 receptor antagonist	51481-61-9
Ciproxifan	Histamine H3-receptor antagonist	184025-18-1
Clemastine Fumarate		14976-57-9
Clemizole hydrochloride	H1 histamine receptor antagonist	1163-36-6
Cyclizine 2HCl		5897-18-7
Cyproheptadine hydrochloride		969-33-5
Desloratadine		100643-71-8
Epinastine HCl		108929-04-0
Famotidine	Histamine H2-receptor antagonist	76824-35-6
Fexofenadine HCl		153439-40-8
Histamine 2HCl		56-92-8
Histamine Phosphate		51-74-1
Hydroxyzine 2HCl		2192-20-3
JNJ-7777120	Histamine H4 receptor antagonist	459168-41-3
Ketotifen Fumarate		34580-14-8
Lafutidine		118288-08-7
Levodropropizine	Histamine receptor inhibitor,cough suppressant	99291-25-5
Lidocaine	Anasthetic and class Ib antiarrhythmic agent	137-58-6
Loratadine	Peripheral HH1R antagonist	79794-75-5
Mianserin HCl	5-HT2 receptor antagonist	21535-47-7
Mizolastine		108612-45-9
Nizatidine		76963-41-2
Olopatadine HCl	Histamine blocker	140462-76-6
Pemirolast potassium		100299-08-9
Ranitidine	Histamine H2-receptor antagonist	66357-59-3
Roxatidine Acetate HCl		93793-83-0
Rupatadine Fumarate		182349-12-8
Serotonin HCl		153-98-0
Tripelennamine HCl	H1-receptor antagonist	154-69-8

Drug Products

Tocris compounds for HRH3

ApexBio compounds for HRH3

Transcripts for HRH3 Gene

mRNA/cDNA for HRH3 Gene

(3) REFSEQ mRNAs :

(11) Additional mRNA sequences :

(23) Selected AceView cDNA sequences:

(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HRH3 Gene

Histamine receptor H3:

Hs.251399

Representative Sequences:

AF140538

CRISPR Products

OriGene CRISPR knockouts for HRH3
- KN218388

genomics-online: gRNA clones - Search results for available HRH3 gene related products

Applied Biological Materials CRISPR for HRH3
Vectors and viruses for KO, Activation, Repression, and more
- HRH3-CRISPR-CAS9-Knockout

Santa Cruz Biotechnology (SCBT) CRISPR for HRH3

GenScript: Design CRISPR guide RNA sequences for HRH3

miRNA Products

Search ViGene Biosciences for HRH3

SwitchGear HRH3 3' UTR sequence
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Browse OriGene miRNA Products For HRH3

Inhibitory RNA Products

Origene shrna and RNAi products in human, mouse, rat for HRH3
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genomics-online: shRNA clones - Search results for available HRH3 gene related products

ViGene Biosciences ready-to-package AAV shRNAs for HRH3 gene
- SH800147

Search Santa Cruz Biotechnology (SCBT) for HRH3 siRNA/shRNA

Clone Products

OriGene clones in human for HRH3
- SC303895
OriGene ORF clones in human for HRH3
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Addgene plasmids for HRH3

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ProteoGenix Custom Cloning/Gene Synthesis Service (Subcloning and Mutagenesis/Gene Library Synthesis)

Applied Biological Materials Clones for HRH3
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- HRH3

R&D Systems cDNA Clones for HRH3 (Histamine H3 R)

Alternative Splicing Database (ASD) splice patterns (SP) for HRH3 Gene

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5a	·	5b
SP1:			-
SP2:			-								-
SP3:			-
SP4:

Relevant External Links for HRH3 Gene

GeneLoc Exon Structure for: HRH3
ECgene alternative splicing isoforms for: HRH3

Expression for HRH3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HRH3 Gene

mRNA expression in normal human tissues for HRH3 Gene

mRNA differential expression in normal tissues according to GTEx for HRH3 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x9.2), Brain - Nucleus accumbens (basal ganglia) (x8.4), Brain - Caudate (basal ganglia) (x6.4), Brain - Hypothalamus (x4.9), and Brain - Cerebellum (x4.8).

NURSA nuclear receptor signaling pathways regulating expression of HRH3 Gene:

HRH3

SOURCE GeneReport for Unigene cluster for HRH3 Gene:

Hs.251399

mRNA Expression by UniProt/SwissProt for HRH3 Gene:

Q9Y5N1-HRH3_HUMAN

Tissue specificity: Expressed predominantly in the CNS, with the greatest expression in the thalamus and caudate nucleus. The various isoforms are mainly coexpressed in brain, but their relative expression level varies in a region-specific manner. Isoform 3 and isoform 7 are highly expressed in the thalamus, caudate nucleus and cerebellum while isoform 5 and isoform 6 show a poor expression. Isoform 5 and isoform 6 show a high expression in the amygdala, substantia nigra, cerebral cortex and hypothalamus. Isoform 7 is not found in hypothalamus or substantia nigra.

Evidence on tissue expression from TISSUES for HRH3 Gene

Nervous system(4.6)
Blood(4.2)

Primer Products

OriGene qPCR primer pairs for HRH3
- HP209994
OriGene qPCR primer pairs and template standards for HRH3
- HK210001

genomics-online: primer clones - Search results for available HRH3 gene related products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HRH3 Gene

Orthologs for HRH3 Gene

This gene was present in the common ancestor of animals.

Orthologs for HRH3 Gene

Organism	Taxonomy	Gene	Similarity	Type	Details
chimpanzee (Pan troglodytes)	Mammalia	HRH3 ³⁴	98 (a)	OneToOne	20:59486944-59491557
dog (Canis familiaris)	Mammalia	HRH3 ³³ ³⁴	90.25 (n)		477282 XM_005635258.1 XP_005635315.1 24:46240974-46243149
cow (Bos Taurus)	Mammalia	HRH3 ³³ ³⁴	88.67 (n)		789851 XM_002692258.2 XP_002692304.2 13:55519323-55521407
mouse (Mus musculus)	Mammalia	Hrh3 ³³ ¹⁶ ³⁴	87.49 (n)		99296 NM_133849.3 NP_598610.1 180099465 2:180099465-180104488
rat (Rattus norvegicus)	Mammalia	Hrh3 ³³	87.34 (n)		85268 NM_053506.2 NP_445958.1
oppossum (Monodelphis domestica)	Mammalia	HRH3 ³⁴	80 (a)	OneToOne	1:477976549-477984562
platypus (Ornithorhynchus anatinus)	Mammalia	HRH3 ³⁴	73 (a)	OneToOne	Ultra337:490001-494129
chicken (Gallus gallus)	Aves	HRH3 ³³ ³⁴	69.88 (n)		428147 XM_004947083.1 XP_004947140.1 20:8120601-8123051
lizard (Anolis carolinensis)	Reptilia	HRH3 ³⁴	66 (a)	OneToOne	4:150769383-150800052
tropical clawed frog (Silurana tropicalis)	Amphibia	hrh3 ³³	67.16 (n)		100497857 XM_002939817.2 XP_002939863.2
tropical clawed frog (Silurana tropicalis)	Amphibia	Str.4253 ³³			AL848045.2
zebrafish (Danio rerio)	Actinopterygii	LOC100334962 ³³	69.4 (n)		100334962 XM_003200921.2 XP_003200969.1
zebrafish (Danio rerio)	Actinopterygii	hrh3 ³⁴	48 (a)	OneToOne	7:44478526-44481652
fruit fly (Drosophila melanogaster)	Insecta	CG7918 ³⁴	12 (a)	OneToMany	3R:3885006-3912767
worm (Caenorhabditis elegans)	Secernentea	gar-2 ³⁴	15 (a)	ManyToMany	III:6309378-6320871
worm (Caenorhabditis elegans)	Secernentea	gar-1 ³⁴	13 (a)	ManyToMany	X:6479638-6484810
sea squirt (Ciona savignyi)	Ascidiacea	-- ³⁴	20 (a)	ManyToMany	reftig_312:443694-450782
sea squirt (Ciona savignyi)	Ascidiacea	-- ³⁴	18 (a)	ManyToMany	reftig_16:3637470-3646586

Species where no ortholog for HRH3 was found in the sources mined by GeneCards:

A. gosspyii yeast (Ashbya gossypii)
Actinobacteria (Mycobacterium tuberculosis)
African clawed frog (Xenopus laevis)
African malaria mosquito (Anopheles gambiae)
Alicante grape (Vitis vinifera)
alpha proteobacteria (Wolbachia pipientis)
amoeba (Dictyostelium discoideum)
Archea (Pyrococcus horikoshii)
baker's yeast (Saccharomyces cerevisiae)
barley (Hordeum vulgare)
beta proteobacteria (Neisseria meningitidis)
bread mold (Neurospora crassa)
Chromalveolata (Phytophthora infestans)
common water flea (Daphnia pulex)
corn (Zea mays)
E. coli (Escherichia coli)
filamentous fungi (Aspergillus nidulans)
Firmicute bacteria (Streptococcus pneumoniae)
fission yeast (Schizosaccharomyces pombe)
green algae (Chlamydomonas reinhardtii)
honey bee (Apis mellifera)
K. lactis yeast (Kluyveromyces lactis)
loblloly pine (Pinus taeda)
malaria parasite (Plasmodium falciparum)
medicago trunc (Medicago Truncatula)
moss (Physcomitrella patens)
orangutan (Pongo pygmaeus)
pig (Sus scrofa)
rainbow trout (Oncorhynchus mykiss)
rice (Oryza sativa)
rice blast fungus (Magnaporthe grisea)
schistosome parasite (Schistosoma mansoni)
sea anemone (Nematostella vectensis)
sea urchin (Strongylocentrotus purpuratus)
sorghum (Sorghum bicolor)
soybean (Glycine max)
stem rust fungus (Puccinia graminis)
sugarcane (Saccharum officinarum)
thale cress (Arabidopsis thaliana)
tomato (Lycopersicon esculentum)
toxoplasmosis (Toxoplasma gondii)
Trichoplax (Trichoplax adhaerens)
wheat (Triticum aestivum)

Evolution for HRH3 Gene

ENSEMBL:: Gene Tree for HRH3 (if available)
TreeFam:: Gene Tree for HRH3 (if available)

Paralogs for HRH3 Gene

HRH4 ⁵
CHRM5 ⁵
CHRM1 ⁵
CHRM3 ⁵
CHRM4 ⁵
CHRM2 ⁵
HRH1 ⁵

(17) SIMAP similar genes for HRH3 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for HRH3 Gene

PGOHUM00000293848

Variants for HRH3 Gene

Sequence variations from dbSNP and Humsavar for HRH3 Gene

SNP ID	Clin	Chr 20 pos	Variation	Type
rs1000467386	--	62,220,705(-)	T/G	upstream_transcript_variant
rs1000735503	--	62,220,964(-)	G/A	upstream_transcript_variant
rs1000839224	--	62,220,551(-)	G/A	upstream_transcript_variant
rs1001202932	--	62,214,926(-)	G/A/T	3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1001209005	--	62,222,012(-)	G/A	upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HRH3 Gene

Variant ID	Type	Subtype	PubMed ID
esv2422398	CNV	duplication	17116639
nsv1160689	CNV	deletion	26073780
nsv470556	CNV	loss	18288195
nsv518296	CNV	loss	19592680
nsv955149	CNV	deletion	24416366

Variation tolerance for HRH3 Gene

Residual Variation Intolerance Score: 33.6% of all genes are more intolerant (likely to be disease-causing)

Gene Damage Index Score: 0.93; 19.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HRH3 Gene

Human Gene Mutation Database (HGMD): HRH3
SNPedia medical, phenotypic, and genealogical associations of SNPs for: HRH3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HRH3 Gene

Disorders for HRH3 Gene

(8) MalaCards diseases for HRH3 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder	Aliases	PubMed IDs
hepatic coma	hepatocerebral intoxication
kleine-levin hibernation syndrome	kleine-levin syndrome
recurrent hypersomnia	primary recurrent hypersomnia
central nervous system disease	cns	14529362
migraine with or without aura 1	migraine with or without aura, susceptibility to, 1	18942262

- elite association - COSMIC cancer census association via MalaCards

Search HRH3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HRH3

Genetic Association Database: (GAD)
Human Genome Epidemiology Navigator: (HuGE)
: ATLAS of Genetics and Cytogenetics in Oncology and Haematology

Search disorders for HRH3 gene in PubMed and other databases

No data available for UniProtKB/Swiss-Prot and Genatlas for HRH3 Gene

Publications for HRH3 Gene

Cloning and functional expression of the human histamine H3 receptor. (PMID: 10347254) Lovenberg TW … Erlander MG (Molecular pharmacology 1999) ² ³ ⁴ ²² ⁵⁸
Structure of the human histamine H3 receptor gene (HRH3) and identification of naturally occurring variations. (PMID: 11956964) Wiedemann P … Brüss M (Journal of neural transmission (Vienna, Austria : 1996) 2002) ³ ⁴ ²² ⁵⁸
Molecular cloning and characterization of a new human histamine receptor, HH4R. (PMID: 11118334) Nakamura T … Tanaka K (Biochemical and biophysical research communications 2000) ³ ⁴ ²² ⁵⁸
Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PMID: 20602615) Ruaño G … Wu AH (Pharmacogenomics 2010) ³ ⁴⁴ ⁵⁸
Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. (PMID: 18996102) Ruaño G … Hanks S (Clinica chimica acta; international journal of clinical chemistry 2009) ³ ⁴⁴ ⁵⁸