Aliases for HRH3 Gene
Aliases for HRH3 Gene
External Ids for HRH3 Gene
- HGNC: 5184
- Entrez Gene: 11255
- Ensembl: ENSG00000101180
- OMIM: 604525
- UniProtKB: Q9Y5N1
Previous GeneCards Identifiers for HRH3 Gene
- GC20M060553
- GC20M061428
- GC20M061475
- GC20M060223
- GC20M060790
- GC20M057566
Summaries for HRH3 Gene
-
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smooth muscles and innervates the blood vessels and the heart in cardiovascular system. [provided by RefSeq, Jul 2008]
GeneCards Summary for HRH3 Gene
HRH3 (Histamine Receptor H3) is a Protein Coding gene. Diseases associated with HRH3 include Hepatic Coma and Kleine-Levin Hibernation Syndrome. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and histamine receptor activity. An important paralog of this gene is HRH4.
UniProtKB/Swiss-Prot for HRH3 Gene
-
The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.
-
Histamine H3 receptors are Galphai/o-protein-coupled receptors expressed at high levels on histaminergic neurons in the CNS, particularly in the basal ganglia, cortex and hippocampus. H3 receptors are thought to function as presynaptic autoreceptors.
Additional gene information for HRH3 Gene
- Monarch Initiative
- Search for HRH3 at DataMed
- Search for HRH3 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HRH3 Gene
Genomics for HRH3 Gene
GeneHancer (GH) Regulatory Elements for HRH3 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH20I062220 | Promoter/Enhancer | 1.8 | EPDnew Ensembl ENCODE | 550.8 | +0.0 | 31 | 0.5 | HDAC1 NFIB ARID4B SIN3A DNMT3B ZNF48 ZSCAN9 RARA SLC30A9 ZNF766 | HRH3 PIR52239 | |
GH20I062245 | Enhancer | 0.9 | ENCODE dbSUPER | 12.3 | -26.5 | -26495 | 1.7 | SOX13 MXI1 SAP130 ZNF449 ZFP64 ARID4B MAX RARA TEAD3 SCRT2 | HRH3 LAMA5-AS1 MTG2 ENSG00000226332 OSBPL2 GC20M062290 | |
GH20I062186 | Enhancer | 0.8 | Ensembl ENCODE | 11.7 | +32.8 | 32790 | 1.4 | SCRT1 HLF CBFA2T3 PAX8 EGR1 SCRT2 IKZF1 SPI1 | SS18L1 PSMA7 HRH3 MTG2 PIR52239 | |
GH20I062240 | Enhancer | 0.7 | Ensembl ENCODE | 12.7 | -21.9 | -21858 | 2.6 | SIN3A ELF1 ZBTB33 KDM1A NFE2 NR2F2 | HRH3 OSBPL2 LAMA5-AS1 GC20M062290 | |
GH20I062010 | Enhancer | 0.8 | ENCODE | 10.6 | +209.2 | 209248 | 0.2 | ELF3 ARID4B SIN3A DMAP1 ZNF48 RAD21 ARID2 SMARCA5 ZNF654 USF2 | PSMA7 SS18L1 HRH3 CDH4 LOC105372704 GC20M062040 TAF4 |
Regulatory Element Products
Genomic Locations for HRH3 Gene
- chr20:62,214,766-62,220,278
- (GRCh38/hg38)
- Size:
- 5,513 bases
- Orientation:
- Minus strand
- chr20:60,790,017-60,795,323
- (GRCh37/hg19)
Genomic View for HRH3 Gene
- Cytogenetic band:
-
- 20q13.33 by Ensembl
- 20q13.33 by Entrez Gene
- 20q13.33 by HGNC


RefSeq DNA sequence for HRH3 Gene
Proteins for HRH3 Gene
-
Protein details for HRH3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y5N1-HRH3_HUMAN
- Recommended name:
- Histamine H3 receptor
- Protein Accession:
- Q9Y5N1
- Q4QRI7
- Q9GZX2
- Q9H4K8
Protein attributes for HRH3 Gene
- Size:
- 445 amino acids
- Molecular mass:
- 48671 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- Does not bind to cimetidine and tripolidine. Shows modest affinity for thioperamide, imetit, N-alpha-methylhistamine and R(-)-alpha-methylhistamine. Isoform 4 is unable to bind to iodoproxyfan while isoforms 1 and 3 bind it with high affinity.
Post-translational modifications for HRH3 Gene
- Glycosylation at posLast=1111
Other Protein References for HRH3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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Domains & Families for HRH3 Gene
Gene Families for HRH3 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- FDA approved drug targets
- G-protein coupled receptors
- Predicted membrane proteins
Protein Domains for HRH3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HRH3 Gene
Graphical View of Domain Structure for InterPro Entry
Q9Y5N1- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for HRH3 Gene
Molecular function for HRH3 Gene
- UniProtKB/Swiss-Prot Function:
- The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004871 | signal transducer activity | IEA | -- |
GO:0004930 | G-protein coupled receptor activity | IEA | -- |
GO:0004969 | histamine receptor activity | IBA,IEA | -- |
Phenotypes for HRH3 Gene
- MGI mutant phenotypes for HRH3:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for HRH3:
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-
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No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for HRH3 Gene
Localization for HRH3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HRH3 Gene
- Cell membrane; Multi-pass membrane protein.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | TAS | 10347254 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0045202 | synapse | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for HRH3 Gene
Pathways & Interactions for HRH3 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors | ||
2 | Signaling by GPCR | ||
3 | Monoamine GPCRs | ||
4 | Monoamine Transport |
Pathways by source for HRH3 Gene
2 BioSystems pathways for HRH3 Gene
8 Reactome pathways for HRH3 Gene
1 KEGG pathway for HRH3 Gene
Interacting Proteins for HRH3 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G-protein coupled receptor signaling pathway | IEA,TAS | -- |
GO:0007187 | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | TAS | 10347254 |
GO:0007194 | negative regulation of adenylate cyclase activity | IBA | -- |
GO:0007269 | neurotransmitter secretion | TAS | 10347254 |
No data available for SIGNOR curated interactions for HRH3 Gene
Drugs & Compounds for HRH3 Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Histamine | Approved, Investigational | Pharma | Full agonist, Agonist, Target, agonist | 1105 | ||
Betahistine | Approved, Investigational | Pharma | Target, antagonist | 16 | ||
Cimetidine | Approved, Investigational | Pharma | Inhibition, Inhibitor | H2 receptor antagonist | 81 | |
calcium | Approved | Nutra | 0 | |||
Mirtazapine | Approved | Pharma | Target, antagonist | 97 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
(<i>R</i>)-alpha-methylhistamine |
|
Full agonist, Agonist |
|
|||
(<i>S</i>)-alpha-methylhistamine |
|
Full agonist, Agonist |
|
|||
[<sup>3</sup>H](<i>R</i>)-alpha-methylhistamine |
|
Full agonist, Agonist |
|
|||
1-[4-(3-piperidin-1-ylpropoxy)benzyl]piperidine |
|
Antagonist |
|
|||
4-(3-piperdin-1-yl-propoxy)benzonitrile |
|
Antagonist |
|
(5) Tocris Compounds for HRH3 Gene
Compound | Action | Cas Number |
---|---|---|
(R)-(-)-alpha-Methylhistamine dihydrobromide | Potent, standard H3 agonist | 868698-49-1 |
(S)-(+)-alpha-Methylhistamine dihydrobromide | H3 agonist, less active enantiomer | 75614-93-6 |
Imetit dihydrobromide | Standard H3 and H4 agonist (H3 > H4) | 32385-58-3 |
Immepip dihydrobromide | Standard H3 agonist. Also H4 agonist | 164391-47-3 |
Nalpha-Methylhistamine dihydrochloride | Non-selective H3 agonist | 16503-22-3 |
(44) ApexBio Compounds for HRH3 Gene
Compound | Action | Cas Number |
---|---|---|
A 331440 dihydrochloride | H3 receptor antagonist,non-imidazole,high affinity | 1049740-32-0 |
Astemizole | 68844-77-9 | |
Azatadine dimaleate | 3978-86-7 | |
Azelastine HCl | 79307-93-0 | |
Bavisant | Human H3 receptor antagonist | 929622-08-2 |
Bavisant dihydrochloride | Human H3 receptor antagonist | 929622-09-3 |
Bavisant dihydrochloride hydrate | Human H3 receptor antagonist | 1103522-80-0 |
Benztropine mesylate | 132-17-2 | |
Bepotastine Besilate | 190786-44-8 | |
Betahistine 2HCl | 5579-84-0 | |
Brompheniramine hydrogen maleate | 980-71-2 | |
Buclizine HCl | 129-74-8 | |
Cetirizine | Antihistamine | 83881-51-0 |
Cetirizine DiHCl | H1 receptor inverse agonist | 83881-52-1 |
Chlorpheniramine Maleate | 113-92-8 | |
Cimetidine | H2 receptor antagonist | 51481-61-9 |
Ciproxifan | Histamine H3-receptor antagonist | 184025-18-1 |
Clemastine Fumarate | 14976-57-9 | |
Clemizole hydrochloride | H1 histamine receptor antagonist | 1163-36-6 |
Cyclizine 2HCl | 5897-18-7 | |
Cyproheptadine hydrochloride | 969-33-5 | |
Desloratadine | 100643-71-8 | |
Epinastine HCl | 108929-04-0 | |
Famotidine | Histamine H2-receptor antagonist | 76824-35-6 |
Fexofenadine HCl | 153439-40-8 | |
Histamine 2HCl | 56-92-8 | |
Histamine Phosphate | 51-74-1 | |
Hydroxyzine 2HCl | 2192-20-3 | |
JNJ-7777120 | Histamine H4 receptor antagonist | 459168-41-3 |
Ketotifen Fumarate | 34580-14-8 | |
Lafutidine | 118288-08-7 | |
Levodropropizine | Histamine receptor inhibitor,cough suppressant | 99291-25-5 |
Lidocaine | Anasthetic and class Ib antiarrhythmic agent | 137-58-6 |
Loratadine | Peripheral HH1R antagonist | 79794-75-5 |
Mianserin HCl | 5-HT2 receptor antagonist | 21535-47-7 |
Mizolastine | 108612-45-9 | |
Nizatidine | 76963-41-2 | |
Olopatadine HCl | Histamine blocker | 140462-76-6 |
Pemirolast potassium | 100299-08-9 | |
Ranitidine | Histamine H2-receptor antagonist | 66357-59-3 |
Roxatidine Acetate HCl | 93793-83-0 | |
Rupatadine Fumarate | 182349-12-8 | |
Serotonin HCl | 153-98-0 | |
Tripelennamine HCl | H1-receptor antagonist | 154-69-8 |
Transcripts for HRH3 Gene
mRNA/cDNA for HRH3 Gene
- (3) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (23) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
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ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||
SP2: | - | - | |||||||||||
SP3: | - | ||||||||||||
SP4: |
Expression for HRH3 Gene
mRNA differential expression in normal tissues according to GTEx for HRH3 Gene
NURSA nuclear receptor signaling pathways regulating expression of HRH3 Gene:
HRH3SOURCE GeneReport for Unigene cluster for HRH3 Gene:
Hs.251399mRNA Expression by UniProt/SwissProt for HRH3 Gene:
Q9Y5N1-HRH3_HUMANEvidence on tissue expression from TISSUES for HRH3 Gene
- Nervous system(4.6)
- Blood(4.2)
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No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HRH3 Gene
Orthologs for HRH3 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | HRH3 34 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | HRH3 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | HRH3 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Hrh3 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Hrh3 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | HRH3 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | HRH3 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | HRH3 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | HRH3 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | hrh3 33 |
|
||
Str.4253 33 |
|
||||
zebrafish (Danio rerio) |
Actinopterygii | LOC100334962 33 |
|
||
hrh3 34 |
|
OneToOne | |||
fruit fly (Drosophila melanogaster) |
Insecta | CG7918 34 |
|
OneToMany | |
worm (Caenorhabditis elegans) |
Secernentea | gar-2 34 |
|
ManyToMany | |
gar-1 34 |
|
ManyToMany | |||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
-- 34 |
|
ManyToMany |
- Species where no ortholog for HRH3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for HRH3 Gene
(17) SIMAP similar genes for HRH3 Gene using alignment to 7 proteins:
Pseudogenes.org Pseudogenes for HRH3 Gene
Variants for HRH3 Gene
SNP ID | Clin | Chr 20 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000467386 | -- | 62,220,705(-) | T/G | upstream_transcript_variant | |
rs1000735503 | -- | 62,220,964(-) | G/A | upstream_transcript_variant | |
rs1000839224 | -- | 62,220,551(-) | G/A | upstream_transcript_variant | |
rs1001202932 | -- | 62,214,926(-) | G/A/T | 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant | |
rs1001209005 | -- | 62,222,012(-) | G/A | upstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2422398 | CNV | duplication | 17116639 |
nsv1160689 | CNV | deletion | 26073780 |
nsv470556 | CNV | loss | 18288195 |
nsv518296 | CNV | loss | 19592680 |
nsv955149 | CNV | deletion | 24416366 |
Additional Variant Information for HRH3 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HRH3 Gene
Disorders for HRH3 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
hepatic coma |
|
|
kleine-levin hibernation syndrome |
|
|
recurrent hypersomnia |
|
|
central nervous system disease |
|
|
migraine with or without aura 1 |
|
Additional Disease Information for HRH3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for HRH3 Gene
Publications for HRH3 Gene
- Cloning and functional expression of the human histamine H3 receptor. (PMID: 10347254) Lovenberg TW … Erlander MG (Molecular pharmacology 1999) 2 3 4 22 58
- Structure of the human histamine H3 receptor gene (HRH3) and identification of naturally occurring variations. (PMID: 11956964) Wiedemann P … Brüss M (Journal of neural transmission (Vienna, Austria : 1996) 2002) 3 4 22 58
- Molecular cloning and characterization of a new human histamine receptor, HH4R. (PMID: 11118334) Nakamura T … Tanaka K (Biochemical and biophysical research communications 2000) 3 4 22 58
- Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PMID: 20602615) Ruaño G … Wu AH (Pharmacogenomics 2010) 3 44 58
- Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. (PMID: 18996102) Ruaño G … Hanks S (Clinica chimica acta; international journal of clinical chemistry 2009) 3 44 58
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- Novus Biologicals Antibodies for HRH3
- Novus Biologicals proteins for HRH3
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- Abcam antibodies for HRH3
- Abcam proteins for HRH3
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- Cloud-Clone Corp. disease models service
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- Invitrogen Antibodies for HRH3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for HRH3
- Addgene plasmids for HRH3
- antibodies-online: Search results for 136 available HRH3 Antibodies ranked by validation data
- Compare Top HRH3 Antibodies
- Recommended
- 91 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 8 IHC (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 3 IP Antibodies (anti-human)
- 31 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 3 IP Antibodies (anti-mouse)
- 36 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 3 IP Antibodies (anti-rat)
- antibodies-online: Search results for 4 available HRH3 Elisa Kits ranked by validation data
- Compare Top HRH3 Elisa Kits
- Recommended
- antibodies-online: Search results for 5 available HRH3 Proteins ranked by validation data
- Compare Top HRH3 Proteins
- GeneTex HRH3 antibody for HRH3
- Search GeneTex for Proteins for HRH3
- ViGene Biosciences adenoviral particle packaged cDNA for HRH3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HRH3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HRH3 gene
- Search ViGene Biosciences for HRH3
- Santa Cruz Biotechnology (SCBT) Antibodies for HRH3
- Search Santa Cruz Biotechnology (SCBT) for HRH3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HRH3
- Horizon Cell Lines for HRH3
- genomics-online: cdna clones - Search results for available HRH3 gene related products
- orf clones - Search results for available HRH3 gene related products
- genomics-online: gRNA clones - Search results for available HRH3 gene related products
- genomics-online: primer clones - Search results for available HRH3 gene related products
- genomics-online: shRNA clones - Search results for available HRH3 gene related products
Sources for HRH3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew