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HRH3 Gene

protein-coding GIFtS: 64
GCID: GC20M060790

Histamine Receptor H3

See HRH3-related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Histamine Receptor H3¹ ²		G-Protein Coupled Receptor 97² ³
GPCR97² ³ ⁵		G Protein-Coupled Receptor 97²
H3R² ³		Histamine H3 Receptor²
HH3R² ³

External Ids:	HGNC: 5184¹	Entrez Gene: 11255²	Ensembl: ENSG00000101180⁷	OMIM: 604525⁵	UniProtKB: Q9Y5N1³

Export aliases for HRH3 gene to outside databases

Previous GC identifers: GC20M060553 GC20M061428 GC20M061475 GC20M060223 GC20M057566

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HRH3 Gene:

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons.

Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine

receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein

and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in

smooth muscles and innervates the blood vessels and the heart in cardiovascular system. (provided by RefSeq, Jul

2008)

GeneCards Summary for HRH3 Gene:

HRH3 (histamine receptor H3) is a protein-coding gene. Diseases associated with HRH3 include hepatic coma, and sleep disorder. GO annotations related to this gene include histamine receptor activity. An important paralog of this gene is HTR2A.

UniProtKB/Swiss-Prot: HRH3_HUMAN, Q9Y5N1

Function: The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous

system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous

activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity

nor induced intracellular calcium mobilization

summary for HRH3 Gene:

Histamine H3 receptors are Galphai/o-protein-coupled receptors first cloned in 1999. H3 receptors are

expressed at high levels on histaminergic neurons in the central nervous system, particularly in the basal

ganglia, cortex, hippocampus and strial area. They are expressed in the periphery at lower densities in the

gastrointestinal, bronchial and cardiovascular systems. H3 receptors are thought to function as presynaptic

autoreceptors, and activation stimulates the negative feedback mechanism that reduces central histaminergic

activity. These receptors have displayed heterogeneity in binding and functional studies, suggesting

multiple subtypes. In rats, three H3 receptor subtypes have been indentified and they all vary in the length

of the third extracellular loop, have distinct CNS localization and differentially couple to adenylyl

cyclase and MAPK signaling pathways. H3 receptors have multiple functions including roles in cognition,

sleep-wake status, energy homeostasis regulation and inflammation. Activation of these receptors can inhibit

histamine, dopamine, serotonin, noradrenalin and acetylcholine release and they participate in control of

neurogenic inflammation through local-neuron feedback loops. Furthermore, H3 receptor activation increases

antigen-presenting cell capacity. H3 receptors are thought to have pathophysiological relevance and are

involved in cognitive impairment, seizures and possibly metabolic syndrome. The human gene encoding this

receptor is localized to chromosome 20q13.33.

Gene Wiki entry for HRH3 (Histamine H3 receptor) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000020.10 NT_011362.11 NC_018931.2

Regulatory elements:

Regulatory transcription factor binding sites in the HRH3 gene promoter:
ER-alpha USF1 Spz1 HTF Olf-1 C/EBPalpha Arnt CBF-A USF-1 CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HRH3 promoter sequence

Search Chromatin IP Primers for HRH3

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HRH3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.33 Ensembl cytogenetic band: 20q13.33 HGNC cytogenetic band: 20q13.33

HRH3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HRH3 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M060790: view genomic region (about GC identifiers)

Start:	60,790,017 bp from pter	End:	60,795,323 bp from pter
Size:	5,307 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: HRH3_HUMAN, Q9Y5N1 (See protein sequence)

Recommended Name: Histamine H3 receptor

Size: 445 amino acids; 48671 Da

Miscellaneous: Does not bind to cimetidine and tripolidine. Shows modest affinity for thioperamide, imetit,

N-alpha-methylhistamine and R(-)-alpha-methylhistamine. Isoform 4 is unable to bind to iodoproxyfan while

isoforms 1 and 3 bind it with high affinity

Secondary accessions: Q4QRI7 Q9GZX2 Q9H4K8

Alternative splicing: 7 isoforms: Q9Y5N1-1 Q9Y5N1-2 Q9Y5N1-3 Q9Y5N1-4 Q9Y5N1-5 Q9Y5N1-6 Q9Y5N1-7

Explore the universe of human proteins at neXtProt for HRH3: NX_Q9Y5N1

Explore proteomics data for HRH3 at MOPED

Post-translational modifications:

Glycosylation² at Asn11

Modification sites at PhosphoSitePlus

See HRH3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_009163.2

ENSEMBL proteins:

ENSP00000342560 ENSP00000321482

Reactome Protein details: Q9Y5N1

HRH3 Human Recombinant Protein Products:

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	antibodies-online peptides for HRH3

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	antibodies-online kits for HRH3 (9 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

HGNC Gene Families:

HRH: GPCR / Class A : Histamine receptors

IUPHAR Guide to PHARMACOLOGY protein family classification: H₃ receptor

Histamine receptors

3 InterPro protein domains:

IPR017452 GPCR_Rhodpsn_7TM

IPR003980 Histamine_H3_rcpt

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q9Y5N1

ProtoNet protein and cluster: Q9Y5N1

1 Blocks protein domain: IPB003980 Histamine H3 receptor signature

UniProtKB/Swiss-Prot: HRH3_HUMAN, Q9Y5N1

Similarity: Belongs to the G-protein coupled receptor 1 family

Find genes that share domains with HRH3 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: HRH3_HUMAN, Q9Y5N1

Function: The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous

system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous

activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity

nor induced intracellular calcium mobilization

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004930	G-protein coupled receptor activity	--	--
GO:0004969	histamine receptor activity	IEA	--
GO:0008144	drug binding	IEA	--

Find genes that share ontologies with HRH3 About GenesLikeMe

Phenotypes:
7 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Hrh3):

adipose tissue	behavior/neurological	cardiovascular system	growth/size/body	homeostasis/metabolism
immune system	nervous system

Find genes that share phenotypes with HRH3 About GenesLikeMe

Animal Models:
MGI mouse knock-outs for HRH3: Hrh3^tm1Twl Hrh3^tm1Kot Hrh3^tm1.1Jhwa

genOway: Develop your customized and physiologically relevant rodent model for HRH3

miRNA Products:		Block miRNA regulation of human, mouse, rat HRH3 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate HRH3 (see all 18):
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		SwitchGear 3'UTR luciferase reporter plasmid: HRH3 3' UTR sequence

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DNA2.0 Custom Protein Engineering Service for HRH3

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRH3

Flow Cytometry
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eBioscience FlowRNA Probe Sets ( VA1-11070) for HRH3

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

HRH3_HUMAN, Q9Y5N1: Cell membrane; Multi-pass membrane protein

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
plasma membrane	5
nucleus	1

About this image

Gene Ontology (GO): 5 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral component of plasma membrane	TAS	10347254
GO:0016021	integral component of membrane	--	--
GO:0043005	neuron projection	IEA	--
GO:0043209	myelin sheath	IEA	--

Find genes that share ontologies with HRH3 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for HRH3 About

See pathways by source

Powered
by

SuperPath

Contained pathways About

Peptide ligand-binding receptors

Class A/1 (Rhodopsin-like receptors)	0.71	GPCRs, Class A Rhodopsin-like	0.43
GPCR ligand binding	0.71	Neuroactive ligand-receptor interaction	0.36
G alpha (i) signalling events	0.44

Signaling by GPCR

	Signaling by GPCR	0.90			Signal Transduction	0.58
	GPCR downstream signaling	0.90

Monoamine GPCRs

Amine ligand-binding receptors

0.79

Histamine receptors

0.00

Monoamine Transport

Monoamine Transport

Find genes that share SuperPaths with HRH3 About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

2 BioSystems Pathways for HRH3

	Monoamine Transport
	GPCRs, Class A Rhodopsin-like

2 Reactome Pathways for HRH3

	G alpha (i) signalling events
	Histamine receptors

1 Kegg Pathway (Kegg details for HRH3):

Neuroactive ligand-receptor interaction

Pathway & Disease-focused RT² Profiler PCR Array including HRH3:

G Protein Coupled Receptors 384HT in human mouse rat

Interactions:

Search GeneGlobe Interaction Network for HRH3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for HRH3 (Q9Y5N1³ ENSP00000342560⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 145)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DRD1	P21728³	I2D: score=1
ADCY2	ENSP00000342952⁴	STRING: ENSP00000342952
ADCY4	ENSP00000312126⁴	STRING: ENSP00000312126
ADCY8	ENSP00000286355⁴	STRING: ENSP00000286355
ADORA1	ENSP00000308549⁴	STRING: ENSP00000308549

About this table

Gene Ontology (GO): Selected biological process terms (see all 18): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007186	G-protein coupled receptor signaling pathway	--	--
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	10347254
GO:0007194	negative regulation of adenylate cyclase activity	IEA	--
GO:0007204	positive regulation of cytosolic calcium ion concentration	IEA	--
GO:0007269	neurotransmitter secretion	TAS	10347254

Find genes that share ontologies with HRH3 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Compounds for HRH3 available from Tocris Bioscience About this table

Compound	Action	CAS #
(R)-(-)-alpha-Methylhistamine dihydrobromide	Potent, standard H3 agonist	[75614-87-8]
Thioperamide	H3 antagonist and H4 inverse agonist	[106243-16-7]
Clobenpropit dihydrobromide	Highly potent H3 antagonist and H4 partial agonist	[145231-45-4]
Immepip dihydrobromide	Standard H3 agonist. Also H4 agonist	[164391-47-3]
BF 2649 hydrochloride	H3 receptor inverse agonist/antagonist	[903576-44-3]

2 HMDB Compounds for HRH3 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Histamine	1H-Imidazole-4-ethanamine (see all 27)	51-45-6	--

2 DrugBank Compounds for HRH3 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Histamine Phosphate	--	51-74-1	target	agonist	17652997 16715497 17575572 16599255
Betahistine	--	5638-76-6	target	antagonist	18447604 11700150 20530654

Selected IUPHAR Ligands for HRH3 (H₃ receptor) (see all 38) About this table

Ligand	Type	Action	Affinity	Pubmed IDs
[¹²³I]iodoproxyfan	Antagonist	Antagonist	10.2	11090094
iodoproxyfan	Agonist	Full agonist	10	12393057
immepip	Agonist	Full agonist	8.8 - 9.7	10869375 12393057 11179434 14640553 11284713
imetit	Agonist	Full agonist	8.8 - 9.7	10869375 12393057 11179434 11714875 11284713
ABT-239	Antagonist	Inverse agonist	9.4	15608078
clobenpropit	Antagonist	Antagonist	8.4 - 9.4	10869375 12393057 11179434 12606603 11714875 11090094 11284713
A-349821	Antagonist	Inverse agonist	9.4	15294456
N-methylhistamine	Agonist	Full agonist	8.6 - 9.3	10869375 11179434 11284713
(R)-alpha-methylhistamine	Agonist	Full agonist	8.4 - 9.2	10869375 12393057 11179434 11714875 11090094 11284713
1-[4-(3-piperidin-1-ylpropoxy)benzyl]piperidine	Antagonist	Antagonist	9.2	12930154

Selected Novoseek inferred chemical compound relationships for HRH3 gene (see all 28) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
thioperamide	94.4	9	8564266 (2), 9640366 (1), 9455995 (1), 15544557 (1) (see all 7)
imetit	93.6	3	9865516 (1), 9455995 (1), 16532454 (1)
clobenpropit	89.3	2	14729385 (1), 15997873 (1)
immepip	86.6	5	16297617 (2), 9185835 (1), 16532454 (1), 8308858 (1)
histamine	86.4	98	7867658 (3), 9699219 (3), 8448069 (2), 10516658 (2) (see all 69)
alpha methylhistamine	86.1	2	7698611 (1), 9793613 (1)
iodophenpropit	79.8	7	8564266 (3)
tele-methylhistamine	75.5	3	10755377 (1), 12971961 (1)
chlorpheniramine	68.7	2	9455995 (1), 8809785 (1)
mepyramine	65.5	1	8564521 (1)

Find genes that share compounds with HRH3 About GenesLikeMe

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for HRH3 gene (4 alternative transcripts):

NM_007232.2 XM_005260266.1 XM_005260267.2 XM_006723696.1

Unigene Cluster for HRH3:

Histamine receptor H3

Hs.251399 [show with all ESTs]

Unigene Representative Sequence: AF140538

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000340177(uc002ycf.2) ENST00000317393(uc002ych.3 uc002ycg.3 uc002yci.3)

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Flow Cytometry
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Additional mRNA sequence:

AB019000.1 AF140538.1 AF321910.1 AF321911.1 AF321912.1 AF321913.1 AF346903.1 AF346904.1

AF363791.1 AK074730.1 BC096840.1

4 DOTS entries:

DT.100750130 DT.438395 DT.100020634 DT.91731029

23 AceView cDNA sequences:

CB154982 BQ068856 AB019000 AF363791 AK074730 AF346904 AF321911 NM_007232

AF321910 AF346903 BX089742 CF147822 BM548665 AF321912 AF321913 AF140538

BF531112 AB045369 H30846 BE783826 R87218 R87217 H28163

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for HRH3 About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5a	·	5b
SP1:			-
SP2:			-								-
SP3:			-
SP4:

ECgene alternative splicing isoforms for HRH3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HRH3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CTCCTCTGCC

About this image

HRH3 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

HRH3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.251399

UniProtKB/Swiss-Prot: HRH3_HUMAN, Q9Y5N1

Tissue specificity: Expressed predominantly in the CNS, with the greatest expression in the thalamus and caudate

nucleus. The various isoforms are mainly coexpressed in brain, but their relative expression level varies in a

region-specific manner. Isoform 3 and isoform 7 are highly expressed in the thalamus, caudate nucleus and

cerebellum while isoform 5 and isoform 6 show a poor expression. Isoform 5 and isoform 6 show a high expression

in the amygdala, substantia nigra, cerebral cortex and hypothalamus. Isoform 7 is not found in hypothalamus or

substantia nigra

Pathway & Disease-focused RT² Profiler PCR Array including HRH3:

G Protein Coupled Receptors 384HT in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for HRH3 gene from Selected species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Hrh3^{1 , 5}	histamine receptor H3^{1, 5}	87.49(n)¹ 92.36(a)¹		2 (102.62 cM)⁵ 99296¹ NM_133849.3¹ NP_598610.1¹ 172394708⁵
chicken (Gallus gallus)	Aves	HRH3¹	histamine receptor H3	69.88(n) 74.48(a)		428147 XM_004947083.1 XP_004947140.1
lizard (Anolis carolinensis)	Reptilia	HRH3⁶	histamine receptor H3	66(a)	1 ↔ 1	4(150769383-150800052)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.4253²	Transcribed sequence with moderate similarity to protein more	74.05(n)		AL848045.2
zebrafish (Danio rerio)	Actinopterygii	LOC100334962¹	histamine H3 receptor-like	69.4(n) 74.02(a)		100334962 XM_003200921.2 XP_003200969.1
fruit fly (Drosophila melanogaster)	Insecta	CG7918⁶	--	12(a)	1 → many	3R(3885006-3912767)
worm (Caenorhabditis elegans)	Secernentea	gar-2⁶ gar-1⁶	Protein GAR-2, isoform d Protein GAR-1, isoform c (gar-1) mRNA, complete cd...	15(a) 13(a)	many ↔ many many ↔ many	III(6309378-6320871) WBGene00001518 X(6479638-6484810) WBGene00001517

ENSEMBL Gene Tree for HRH3 (if available)
TreeFam Gene Tree for HRH3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for HRH3 gene

HTR2A² DRD4² DRD2² CHRM1² CHRM2² HTR2B² HRH4² HTR2C²

HRH1² CHRM5² DRD3² CHRM4² CHRM3²

17 SIMAP similar genes for HRH3 using alignment to 7 protein entries: HRH3_HUMAN (see all proteins):

DRD2 ADRA1A CHRM5 H4 HTR7 ADRB2

DRD1 HRH4 DRD3 CHRM3 CHRM1 ADRA2B

CHRM2 HTR5A CHRM4 ADRB1 ADRA2C

Find genes that share paralogs with HRH3 About GenesLikeMe

1 Pseudogenes.org Pseudogene for HRH3
PGOHUM00000259137

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs145462518^1,2		--	60789745(+)	`CAGAGC/TGGGCC`	1	--	ds500¹		0	--	--	--	--
rs189300122^1,2	C	--	60789867(+)	`TGGCAG/TGCTGG`	1	--	ds500¹		0	--	--	--	--
rs1739585^1,2	C,F,H	--	60790056(-)	`GCAAAC/ACGTGA`	1	--	ut3¹ ese³		9		MN NS NA WA	1180
rs182141144^1,2	C	--	60790105(+)	`GCGCGC/TGGCAC`	1	--	ut3¹		0	--	--	--	--
rs199654871^1,2	C	--	60790352(+)	`AGGGCA/GTGGGA`	1	--	ut3¹		0	--	--	--	--
rs200791810^1,2	C,F	--	60790460(+)	`TCATCT/CTTCTG`	1	--	ut3¹		1		EU	593
rs187384641^1,2	C	--	60790626(+)	`TTGTCC/TGGGGA`	1	--	ut3¹		0	--	--	--	--
rs189241374^1,2	C	--	60790644(+)	`GGTGTA/GCAGGT`	1	--	ut3¹		0	--	--	--	--
rs201115320^1,2	C	--	60790781(+)	`AGGGGA/GTGGGC`	1	--	ut3¹		0	--	--	--	--
rs181550929^1,2	C	--	60790982(+)	`CGAGCC/TGGGTA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for HRH3 (60790017 - 60795323 bp)

Structural Variations
Database of Genomic Variants (DGV) 10 variations for HRH3: About this table

Variant ID	Type	Subtype	PubMed ID
esv2422398	CNV	Duplication	17116639
dgv4598n71	CNV	Loss	21882294
nsv913040	CNV	Loss	21882294
nsv913047	CNV	Loss	21882294
dgv4597n71	CNV	Loss	21882294
nsv518296	CNV	Loss	19592680
dgv4599n71	CNV	Loss	21882294
nsv470556	CNV	Loss	18288195
dgv4600n71	CNV	Loss	21882294
dgv4601n71	CNV	Loss	21882294

Human Gene Mutation Database (HGMD): HRH3

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing HRH3

DNA2.0 Custom Variant and Variant Library Synthesis for HRH3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

OMIM gene information: 604525 OMIM disorders: --

4 diseases for HRH3:
About MalaCards

hepatic coma sleep disorder schizophrenia attention deficit hyperactivity disorder

2 inferred disease relationships from the University of Copenhagen DISEASES database for HRH3:

Attention deficit hyperactivity disorder Schizophrenia

Find genes that share disorders with HRH3 About GenesLikeMe

Selected Novoseek inferred disease relationships for HRH3 gene (see all 16) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cognitive disorder	68	6	18469850 (1), 19429511 (1), 15608078 (1), 16565470 (1) (see all 6)
cns diseases	40.5	3	14529362 (1), 19429511 (1), 19222483 (1)
attention-deficit hyperactivity disorder	36.7	1	15219708 (1)
schizophrenia	35.7	6	19413576 (3), 15608077 (1), 15219708 (1), 16364652 (1)
catalepsy	25.1	1	15910772 (1)
alzheimers disease	23.9	5	19222483 (2), 15219708 (1), 17327487 (1), 10511950 (1)
migraine	21.8	1	18942262 (1)
parkinson disease	19	6	16532454 (3), 10051746 (1), 10511950 (1), 16738217 (1)
brain diseases	18.8	2	17327487 (1), 19222483 (1)
obesity	5.76	2	16565470 (1), 18221234 (1)

Genetic Association Database (GAD): HRH3
Human Genome Epidemiology (HuGE) Navigator: HRH3 (6 documents)

Export disorders for HRH3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for HRH3 gene, integrated from 10 sources (see all 192):
(articles sorted by number of sources associating them with HRH3)

Cloning and functional expression of the human histamine H3 receptor. (PubMed id 10347254)^{1, 2, 3, 9} Lovenberg T.W.... Erlander M.G. (Mol. Pharmacol. 1999)
Molecular cloning and characterization of a new human histamine receptor, HH4R. (PubMed id 11118334)^{1, 2, 9} Nakamura T.... Tanaka K. (Biochem. Biophys. Res. Commun. 2000)
Structure of the human histamine H3 receptor gene (HRH3) and identification of naturally occurring variations. (PubMed id 11956964)^{1, 2, 9} Wiedemann P.... Bruess M. (J. Neural Transm. 2002)
Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)^{1, 4} RuaA+o G....Wu A.H. (Pharmacogenomics 2010)
Association and interaction analyses of eight genes under asthma linkage peaks. (PubMed id 19824886)^{1, 4} Ferreira M.A....Duffy D.L. (Allergy 2009)
Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)^{1, 4} Need A.C....Goldstein D.B. (Eur. J. Hum. Genet. 2009)
Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. (PubMed id 18996102)^{1, 4} RuaA+o G....Hanks S. ( international journal of clinical chemistry 2009)
Multiple genetic factors in olanzapine-induced weight gain in schizophrenia patients: a cohort study. (PubMed id 19193342)^{1, 4} Ujike H....Kuroda S. (J Clin Psychiatry 2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Genomic organization and characterization of splice variants of the human histamine H3 receptor. (PubMed id 11284713)^{1, 2} Coge F.... Galizzi J.-P. (Biochem. J. 2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 11255	HGNC: 5184	AceView: HRH3	Ensembl:ENSG00000101180	euGenes: HUgn11255
ECgene: HRH3	Kegg: 11255	H-InvDB: HRH3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for HRH3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for HRH3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for HRH3 gene:
Search GeneIP for patents involving HRH3

GeneCards and IP:
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