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HRH2 Gene

protein-coding   GIFtS: 68
GCID: GC05P175085

Histamine Receptor H2

  See HRH2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Histamine Receptor H21 2
Gastric Receptor I2 3
H2R2 3
HH2R2 3
Gastric Receptor 12
Histamine H2 Receptor2

External Ids:    HGNC: 51831   Entrez Gene: 32742   Ensembl: ENSG000001137497   OMIM: 1427035   UniProtKB: P250213   

Export aliases for HRH2 gene to outside databases

Previous GC identifers: GC05P175424 GC05P175931 GC05P175045 GC05P175090 GC05P175042 GC05P170183


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HRH2 Gene:
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons.
Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the
family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid
secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in
regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms
have been found for this gene. (provided by RefSeq, Aug 2008)

GeneCards Summary for HRH2 Gene:
HRH2 (histamine receptor H2) is a protein-coding gene. Diseases associated with HRH2 include laryngitis, and duodenal ulcer. GO annotations related to this gene include histamine receptor activity. An important paralog of this gene is TAAR6.

UniProtKB/Swiss-Prot: HRH2_HUMAN, P25021
Function: The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate
gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation.
The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G
protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity)

summary for HRH2 Gene:
Histamine H2 receptors are Galphas-protein-coupled receptors involved in the suppressive activities of
histamine. H2 receptors exhibit a widespread distribution and are found in the gastrointestinal tract, the
central nervous system, smooth muscle cells, endothelial cells, cardiomyocytes, immune cells and more. H2
receptors regulate various functions of histamine including heart contraction, gastric acid secretion, cell
proliferation and differentiation, and immune responses. In the immune system, H2 activation negatively
regulates basophils and mast cells, and inhibits antibody synthesis, T cell production, cell-mediated
cytolysis and cytokine production. H2 receptors are present on Th2 cells and activation increases the
synthesis of cytokines such as IL-4, Il-5, Il-10 and IL-13. Furthermore, histamine-induced T cell suppressor
activity is mediated through H2 receptors. Due to their role in gastric acid secretion, H2 receptor
overactivity is a cause of gastric ulcers, and pharmacological inhibition of these receptors is an effective
treatment for this condition. The human gene encoding the H2 receptor is localized to chromosome 5q35.3.

Gene Wiki entry for HRH2 (Histamine H2 receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_023133.14  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HRH2 gene promoter:
         SRF   AhR   AML1a   AP-1   SRF (504 AA)   Pax-6   STAT5A   AP-4   FOXC1   Zic1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHRH2 promoter sequence
   Search Chromatin IP Primers for HRH2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HRH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.2   Ensembl cytogenetic band:  5q35.2   HGNC cytogenetic band: 5q35

HRH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HRH2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P175085:  view genomic region     (about GC identifiers)

Start:
175,085,033 bp from pter      End:
175,113,245 bp from pter
Size:
28,213 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HRH2_HUMAN, P25021 (See protein sequence)
Recommended Name: Histamine H2 receptor  
Size: 359 amino acids; 40098 Da
Miscellaneous: Antagonists for this receptor have proven to be effective therapy for acid peptic disorders of the
gastrointestinal tract. Certain antagonists are used in the treatment of neuropsychiatric and neurological
diseases such as schizophrenia, Alzheimer disease and Parkinson disease
Secondary accessions: B5BUP7 Q14464 Q7Z5R9
Alternative splicing: 2 isoforms:  P25021-1   P25021-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HRH2: NX_P25021

Explore proteomics data for HRH2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn4
  • Modification sites at PhosphoSitePlus

  • See HRH2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001124527.1  NP_071640.1  

    ENSEMBL proteins: 
     ENSP00000366506   ENSP00000231683  
    Reactome Protein details: P25021

    HRH2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HRH: GPCR / Class A : Histamine receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: H2 receptor
    Histamine receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn
     IPR000503 Histamine_H2_rcpt

    Graphical View of Domain Structure for InterPro Entry P25021

    ProtoNet protein and cluster: P25021

    1 Blocks protein domain: IPB000503 Histamine H2 receptor signature

    UniProtKB/Swiss-Prot: HRH2_HUMAN, P25021
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with HRH2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HRH2_HUMAN, P25021
    Function: The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate
    gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation.
    The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G
    protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity)

         Genatlas biochemistry entry for HRH2:
    histamine H2 receptor,G protein coupled receptor superfamily,activating adenylate cyclase,stimulating gastric acid
    secretion,increasing contraction of cardiac muscle

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004969histamine receptor activity IEA--
         
    Find genes that share ontologies with HRH2           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Hrh2):
     behavior/neurological  digestive/alimentary  homeostasis/metabolism  nervous system 

    Find genes that share phenotypes with HRH2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for HRH2: Hrh2tm1Yfks Hrh2tm1Wtn

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HRH2
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    miRNA
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    miRTarBase miRNAs that target HRH2:
    hsa-mir-335-5p (MIRT016874)

    Block miRNA regulation of human, mouse, rat HRH2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate HRH2:
    hsa-miR-30b*
    SwitchGear 3'UTR luciferase reporter plasmidHRH2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HRH2_HUMAN, P25021: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    endoplasmic reticulum1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS1714721
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with HRH2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HRH2 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Monoamine GPCRs
    Monoamine GPCRs0.79
    Histamine receptors0.00
    Amine ligand-binding receptors0.79
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Transcription CREB pathway
    Development Ligand independent activation of ESR1 and ESR20.34
    Transcription CREB pathway0.34
    5Salivary secretion
    Gastric acid secretion0.34


    Find genes that share SuperPaths with HRH2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for HRH2
        Development Ligand-independent activation of ESR1 and ESR2
    Transcription CREB pathway

    2 BioSystems Pathways for HRH2
        GPCRs, Class A Rhodopsin-like
    Monoamine GPCRs

    2 Reactome Pathways for HRH2
        Histamine receptors
    G alpha (s) signalling events

    1 PharmGKB Pathway for HRH2
        Proton Pump Inhibitor Pathway, Pharmacodynamics

    3 Kegg Pathways  (Kegg details for HRH2):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Gastric acid secretion

        Pathway & Disease-focused RT2 Profiler PCR Array including HRH2: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for HRH2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for HRH2 (P250213 ENSP000003665064) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GPRASP2Q96D093, ENSP000003390574I2D: score=1 STRING: ENSP00000339057
    SF3A2ENSP000002214944STRING: ENSP00000221494
    GNALENSP000003340514STRING: ENSP00000334051
    GNASENSP000003601414STRING: ENSP00000360141
    HDGFENSP000003571894STRING: ENSP00000357189
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001696gastric acid secretion ----
    GO:0001697histamine-induced gastric acid secretion IEA--
    GO:0001698gastrin-induced gastric acid secretion IEA--
    GO:0003382epithelial cell morphogenesis IEA--
    GO:0006955immune response TAS9725260

    Find genes that share ontologies with HRH2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for HRH2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    HTMT dimaleateH1 / H2 agonist[195867-54-0]
    Amthamine dihydrobromideHighly selective standard H2 agonist[142437-67-0]
    Dimaprit dihydrochlorideStandard H2 selective agonist[23256-33-9]
    Zolantidine dimaleate Potent, centrally active H2 antagonist [104076-38-2]
    Tiotidine Potent, selective H2 antagonist [69014-14-8]

    3 HMDB Compounds for HRH2    About this table
    CompoundSynonyms CAS #PubMed Ids
    FamotidineAmfamox (see all 83)76824-35-6--
    Histamine1H-Imidazole-4-ethanamine (see all 27)51-45-6--
    RanitidineAchedos (see all 52)66357-59-3--

    Selected DrugBank Compounds for HRH2 (see all 12)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    FamotidineFamotidina [Spanish] (see all 2)76824-35-6targetantagonist16513821 2067140 1646056 16702624 12509588 11752352 18310651 12832840 19578661 17273750 16723495
    BetazoleAmetazole (see all 4)105-20-4targetagonist7213132 2886642 2892392 11752352 2874214 3661710
    Nizatidine-- 76963-41-2targetantagonist2895808 2858133 2567267 11752352 2877081 1843561
    Cimetidine-- 51481-61-9targetantagonist10950107 8863950 11752352 16723495
    Histamine Phosphate-- 51-74-1targetagonist17359382 11752352 17334413
    Asenapine-- 65576-45-6targetantagonist21655346 18308814
    Doxepin-- 1668-19-5targetantagonist2141000 2897127
    RanitidineRanitidine HCL (see all 3)66357-35-5targetantagonist7554999 11752352
    EpinastineEpinastina [Spanish] (see all 2)80012-43-7targetantagonist16131920
    MethanthelineBanthine Bromide (see all 7)5818-17-7targetantagonist6116801

    10 IUPHAR Ligands for HRH2 (H2 receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    [3H]tiotidine
    AntagonistAntagonist7.7 - 8.712869657
    arpromidine
    AgonistFull agonist6.3 - 816394198
    impromidine
    AgonistFull agonist7.216394198
    ranitidine
    AntagonistAntagonist7.17921611
    UR-PG136
    AgonistFull agonist716394198
    amthamine
    AgonistFull agonist6.419072936
    UR-PG146
    AgonistFull agonist616394198
    burimamide
    AgonistFull agonist5.6 - 5.79681472
    clobenpropit
    AntagonistAntagonist5.212606603
    ABT-239
    AntagonistInverse agonist5.215608078

    Selected Novoseek inferred chemical compound relationships for HRH2 gene (see all 100)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    histamine 93.1 496 9014481 (12), 1971799 (6), 11521983 (5), 1972605 (5) (see all 99)
    ranitidine 92.1 50 14671421 (3), 11521983 (2), 1974182 (1), 2199130 (1) (see all 43)
    cimetidine 91.4 66 7911673 (2), 15014995 (2), 11521983 (2), 1974182 (1) (see all 59)
    famotidine 91 34 1974182 (1), 2199130 (1), 10222548 (1), 11998377 (1) (see all 30)
    nizatidine 88.8 21 1967857 (2), 1974182 (1), 2199130 (1), 7780679 (1) (see all 15)
    tiotidine 87 2 12869657 (2)
    amthamine 85.9 5 18617631 (1), 8147269 (1), 7781673 (1), 7721041 (1) (see all 5)
    roxatidine 84.6 4 1717223 (1), 16702623 (1), 10462360 (1), 1354631 (1)
    omeprazole 81.8 37 8884305 (3), 9513825 (2), 1978433 (2), 8023719 (2) (see all 31)
    sucralfate 80.6 15 1974182 (1), 15693983 (1), 9010645 (1), 9504939 (1) (see all 14)



    Find genes that share compounds with HRH2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HRH2 gene (2 alternative transcripts): 
    NM_001131055.1  NM_022304.2  

    Unigene Cluster for HRH2:

    Histamine receptor H2
    Hs.247885  [show with all ESTs]
    Unigene Representative Sequence: NM_022304
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377291(uc003mdc.4) ENST00000231683(uc003mdd.2)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat HRH2

    Additional mRNA sequence: 

    AB451483.1 AY136744.1 BC054510.2 

    2 DOTS entries:

    DT.101980161  DT.75155249 

    14 AceView cDNA sequences:

    BF448672 BX282428 NM_022304 BF448622 AY136744 BC054510 BU171745 AI927210 
    BG002844 CF147823 AB023487 CD631354 CD631353 BF360825 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HRH2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCTGCCATC
    HRH2 Expression
    About this image


    HRH2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 15 entries
             Thalamus
             Septum   
    HRH2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HRH2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.247885
        Pathway & Disease-focused RT2 Profiler PCR Array including HRH2: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRH2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for HRH2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hrh21 , 5 histamine receptor H21, 5 83.99(n)1
    86.03(a)1
      13 (28.40 cM)5
    154661  NM_001010973.21  NP_001010973.11 
     541921295 
    chicken
    (Gallus gallus)
    Aves HRH21 histamine receptor H2 67.18(n)
    62.88(a)
      427635  XM_004944905.1  XP_004944962.1 
    lizard
    (Anolis carolinensis)
    Reptilia HRH26
    histamine receptor H2
    57(a)
    1 ↔ 1
    GL343477.1(347249-348343)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia hrh21 histamine receptor H2 61.64(n)
    61.54(a)
      100491392  XM_002938065.2  XP_002938111.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hrh21 histamine receptor H2 59.86(n)
    60.21(a)
      735303  NM_001045338.1  NP_001038803.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG69193
    Octbeta3R1
    G-protein coupled receptor protein
    signaling pathway amine receptor less3
    Octbeta3R1
    37(a)3
    52.23(n)1
    41.2(a)1
      94B23
    38855731  NM_001038954.21  NP_001034043.21 
    worm
    (Caenorhabditis elegans)
    Secernentea M03F4.33 G-protein coupled receptor 39(a)   X(4985611-4990413)   --


    ENSEMBL Gene Tree for HRH2 (if available)
    TreeFam Gene Tree for HRH2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HRH2 gene
    TAAR62  HTR62  TAAR22  ADRB12  TAAR92  TAAR82  DRD12  TAAR12  
    ADRB22  HTR42  ADRB32  DRD52  TAAR52  
    Selected SIMAP similar genes for HRH2 using alignment to 1 protein entry:     HRH2_HUMAN(see all similar genes):
    HTR4    HTR4B    ADRB2    TAAR5    DRD1    TAAR1
    ADORA2B    ADRA1A    ADRA1B    HTR5A    ADRA1D    TAAR2
    TAAR6    ADRB1    HTR7    TAAR3    TAAR8    TAAR9

    Find genes that share paralogs with HRH2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HRH2 (see all 599)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs131764281,2
    C,F--175083166(+) tgggcG/Atggtg 1 -- us2k13Minor allele frequency- A:0.50NA 6
    rs1838177291,2
    --175083195(+) AGCTAC/GTCGGG 1 -- us2k10--------
    rs29132201,2
    C,F--175083217(-) agcaaG/Atctcc 1 -- us2k17Minor allele frequency- A:0.42NA WA CSA 12
    rs609317911,2
    C--175083310(+) ATAAA-/TAAA  
            
    ATAAA
    1 -- us2k11Minor allele frequency- TAAA:0.00NA 2
    rs1874585051,2
    --175083354(+) ATAAAA/TAAAAT 1 -- us2k10--------
    rs1511209391,2
    --175083355(+) TAAATA/TAAATA 1 -- us2k10--------
    rs1410834881,2
    --175083467(+) TTAGAA/TAAGTT 1 -- us2k10--------
    rs1498791891,2
    --175083674(+) GGTGGC/TTCTTG 1 -- us2k10--------
    rs29638541,2
    C,F,H--175083754(+) GTCACA/GGGAGG 1 -- us2k125Minor allele frequency- G:0.39NS EA NA WA CSA 2354
    rs1123690191,2
    C,F--175083811(+) AGAGAC/TTCTCT 1 -- us2k11Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for HRH2 (175085033 - 175113245 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HRH2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv469707CNV Loss16826518

    Human Gene Mutation Database (HGMD): HRH2
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing HRH2
    DNA2.0 Custom Variant and Variant Library Synthesis for HRH2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142703    OMIM disorders: --

    14 diseases for HRH2:    
    About MalaCards
    laryngitis    duodenal ulcer    gastric ulcer    peptic ulcer disease
    interstitial nephritis    gastroesophageal reflux disease    meckel's diverticulum    systemic scleroderma
    zollinger-ellison syndrome    bronchogenic carcinoma    esophagitis    dyspepsia
    urticaria    schizophrenia

    5 diseases from the University of Copenhagen DISEASES database for HRH2:
    Peptic ulcer     Esophagitis     Gastroesophageal reflux disease     Dyspepsia
    Gastritis

    Find genes that share disorders with HRH2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for HRH2 gene (see all 53)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    peptic ulcer 79.1 21 1834730 (1), 10222548 (1), 7527761 (1), 11510196 (1) (see all 20)
    stress ulcer 77.3 7 19318661 (1), 17592004 (1), 1358868 (1), 8701013 (1) (see all 7)
    duodenal ulcer 73.9 18 7525198 (2), 14567455 (2), 9121092 (2), 1600048 (1) (see all 14)
    zollinger-ellison syndrome 73.5 2 7949462 (1), 8104773 (1)
    ulcer 72.2 27 1347323 (1), 1356644 (1), 7881012 (1), 9068463 (1) (see all 26)
    gastric ulcer 71 19 1971799 (3), 7525198 (2), 10606307 (2), 1359134 (2) (see all 14)
    esophagitis 64.7 12 9513825 (2), 7601011 (1), 9165690 (1), 10826019 (1) (see all 11)
    gastroesophageal reflux disease 60.9 4 8480563 (1), 9165690 (1), 12664775 (1), 15683433 (1)
    reflux 59.9 9 8961846 (1), 18600389 (1), 7601011 (1), 15932360 (1) (see all 7)
    duodenal ulcer disease 58.8 1 8284002 (1)

    Genetic Association Database (GAD): HRH2
    Human Genome Epidemiology (HuGE) Navigator: HRH2 (10 documents)

    Export disorders for HRH2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HRH2 gene, integrated from 10 sources (see all 494):
    (articles sorted by number of sources associating them with HRH2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the human histamine H2 receptor. (PubMed id 1714721)1, 2, 3, 9 Gantz I.... Yamada T. (Biochem. Biophys. Res. Commun. 1991)
    2. Human histamine H2 receptor gene: multiple transcription initiation and tissue-specific expression. (PubMed id 10371214)1, 2, 9 Murakami H.... Futai M. (FEBS Lett. 1999)
    3. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (Pharmacogenomics 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (Eur. J. Hum. Genet. 2009)
    6. High-throughput chemiluminometric genotyping of single nucleotide polymorphisms of histamine, serotonin, and adrenergic receptor genes. (PubMed id 19026982)1, 4 Toubanaki D.K....Flordellis C.S. (Anal. Biochem. 2009)
    7. Multiple genetic factors in olanzapine-induced weight gain in schizophrenia patients: a cohort study. (PubMed id 19193342)1, 4 Ujike H....Kuroda S. (J Clin Psychiatry 2008)
    8. Polymorphisms of high-affinity IgE receptor and histamine-related genes in patients with ASA-induced urticaria/angioedema. (PubMed id 15953854)1, 4 Choi J.H....Park H.S. (J. Korean Med. Sci. 2005)
    9. Investigation of promoter variants of the histamine 1 and 2 receptors in schizophrenia and clozapine response. (PubMed id 12429384)1, 4 Mancama D....Kerwin R. (Neurosci. Lett. 2002)
    10. Novel insights into histamine H2 receptor biology. (PubMed id 9374694)1, 2 DelValle J. and Gantz I. (Am. J. Physiol. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3274 HGNC: 5183 AceView: HRH2 Ensembl:ENSG00000113749 euGenes: HUgn3274
    ECgene: HRH2 Kegg: 3274 H-InvDB: HRH2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HRH2 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/H2_receptor

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HRH2 gene:
    Search GeneIP for patents involving HRH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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