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Aliases for HRH2 Gene

Aliases for HRH2 Gene

  • Histamine Receptor H2 2 3 5
  • Gastric Receptor I 3 4
  • HH2R 3 4
  • H2R 3 4
  • Gastric Receptor 1 3

External Ids for HRH2 Gene

Previous GeneCards Identifiers for HRH2 Gene

  • GC05P175424
  • GC05P175931
  • GC05P175045
  • GC05P175090
  • GC05P175042
  • GC05P175085
  • GC05P170183

Summaries for HRH2 Gene

Entrez Gene Summary for HRH2 Gene

  • Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

GeneCards Summary for HRH2 Gene

HRH2 (Histamine Receptor H2) is a Protein Coding gene. Diseases associated with HRH2 include duodenal ulcer and peptic ulcer disease. Among its related pathways are Calcium signaling pathway and Salivary secretion. GO annotations related to this gene include G-protein coupled receptor activity and histamine receptor activity. An important paralog of this gene is TAAR9.

UniProtKB/Swiss-Prot for HRH2 Gene

  • The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity).

Tocris Summary for HRH2 Gene

  • Histamine H2 receptors are Galphas-protein-coupled receptors involved in the suppressive activities of histamine. H2 receptors exhibit a widespread distribution and are found in the gastrointestinal tract, the central nervous system, smooth muscle cells and endothelial cells.

Gene Wiki entry for HRH2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HRH2 Gene

Genomics for HRH2 Gene

Regulatory Elements for HRH2 Gene

Enhancers for HRH2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HRH2 on UCSC Golden Path with GeneCards custom track

Promoters for HRH2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HRH2 on UCSC Golden Path with GeneCards custom track

Genomic Location for HRH2 Gene

Chromosome:
5
Start:
175,657,796 bp from pter
End:
175,710,756 bp from pter
Size:
52,961 bases
Orientation:
Plus strand

Genomic View for HRH2 Gene

Genes around HRH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HRH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HRH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HRH2 Gene

Proteins for HRH2 Gene

  • Protein details for HRH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25021-HRH2_HUMAN
    Recommended name:
    Histamine H2 receptor
    Protein Accession:
    P25021
    Secondary Accessions:
    • B5BUP7
    • Q14464
    • Q7Z5R9

    Protein attributes for HRH2 Gene

    Size:
    359 amino acids
    Molecular mass:
    40098 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Antagonists for this receptor have proven to be effective therapy for acid peptic disorders of the gastrointestinal tract. Certain antagonists are used in the treatment of neuropsychiatric and neurological diseases such as schizophrenia, Alzheimer disease and Parkinson disease.

    Alternative splice isoforms for HRH2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HRH2 Gene

Proteomics data for HRH2 Gene at MOPED

Post-translational modifications for HRH2 Gene

  • Glycosylation at Asn 4
  • Modification sites at PhosphoSitePlus

Other Protein References for HRH2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HRH2 Gene

Domains & Families for HRH2 Gene

Gene Families for HRH2 Gene

Protein Domains for HRH2 Gene

Suggested Antigen Peptide Sequences for HRH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P25021

UniProtKB/Swiss-Prot:

HRH2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HRH2: view

Function for HRH2 Gene

Molecular function for HRH2 Gene

GENATLAS Biochemistry:
histamine H2 receptor,G protein coupled receptor superfamily,activating adenylate cyclase,stimulating gastric acid secretion,increasing contraction of cardiac muscle
UniProtKB/Swiss-Prot Function:
The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity).

Gene Ontology (GO) - Molecular Function for HRH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004969 histamine receptor activity IEA --
genes like me logo Genes that share ontologies with HRH2: view
genes like me logo Genes that share phenotypes with HRH2: view

Animal Models for HRH2 Gene

MGI Knock Outs for HRH2:

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HRH2 Gene

Localization for HRH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HRH2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HRH2 Gene COMPARTMENTS Subcellular localization image for HRH2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytosol 1
endoplasmic reticulum 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for HRH2 Gene

Pathways & Interactions for HRH2 Gene

genes like me logo Genes that share pathways with HRH2: view

Gene Ontology (GO) - Biological Process for HRH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003382 epithelial cell morphogenesis IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0008542 visual learning IEA --
GO:0045907 positive regulation of vasoconstriction IEA --
GO:0048167 regulation of synaptic plasticity IEA --
genes like me logo Genes that share ontologies with HRH2: view

No data available for SIGNOR curated interactions for HRH2 Gene

Drugs & Compounds for HRH2 Gene

(118) Drugs for HRH2 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ranitidine Approved Pharma Antagonist, antagonist, Target Histamine H2-receptor antagonist 74
Cimetidine Approved Pharma Inhibition, Inhibitor, antagonist, Target H2 receptor antagonist, H2 antagonist, I1 agonist 68
Famotidine Approved Pharma antagonist, Target Histamine H2-receptor antagonist 57
Nizatidine Approved Pharma antagonist, Target 8
Histamine Phosphate Approved Pharma Target, agonist 998

(35) Additional Compounds for HRH2 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Aminopotentidine
140873-26-3
Amthamine dihydrobromide
142457-00-9
Dimaprit dihydrochloride
23256-33-9
HTMT dimaleate
195867-54-0

(5) Tocris Compounds for HRH2 Gene

Compound Action Cas Number
Aminopotentidine H2 antagonist 140873-26-3
Amthamine dihydrobromide Highly selective standard H2 agonist 142457-00-9
Dimaprit dihydrochloride Standard H2 selective agonist 23256-33-9
Histamine dihydrochloride Endogenous histamine receptor agonist 56-92-8
HTMT dimaleate H1 / H2 agonist 195867-54-0

(38) ApexBio Compounds for HRH2 Gene

Compound Action Cas Number
Astemizole 68844-77-9
Azatadine dimaleate 3978-86-7
Azelastine HCl 79307-93-0
Benztropine mesylate 132-17-2
Bepotastine Besilate 190786-44-8
Betahistine 2HCl 5579-84-0
Brompheniramine hydrogen maleate 980-71-2
Buclizine HCl 129-74-8
Cetirizine DiHCl H1 receptor inverse agonist 83881-52-1
Chlorpheniramine Maleate 113-92-8
Cimetidine H2 receptor antagonist 51481-61-9
Ciproxifan Histamine H3-receptor antagonist 184025-18-1
Clemastine Fumarate 14976-57-9
Cyclizine 2HCl 5897-18-7
Cyproheptadine hydrochloride 969-33-5
Desloratadine 100643-71-8
Epinastine HCl 108929-04-0
Famotidine Histamine H2-receptor antagonist 76824-35-6
Fexofenadine HCl 153439-40-8
Histamine 2HCl 56-92-8
Histamine Phosphate 51-74-1
Hydroxyzine 2HCl 2192-20-3
JNJ-7777120 Histamine H4 receptor antagonist 459168-41-3
Ketotifen Fumarate 34580-14-8
Lafutidine 118288-08-7
Levodropropizine Histamine receptor inhibitor,cough suppressant 99291-25-5
Lidocaine Anasthetic and class Ib antiarrhythmic agent 137-58-6
Loratadine Peripheral HH1R antagonist 79794-75-5
Mianserin HCl 5-HT2 receptor antagonist 21535-47-7
Mizolastine 108612-45-9
Nizatidine 76963-41-2
Olopatadine HCl Histamine blocker 140462-76-6
Pemirolast potassium 100299-08-9
Ranitidine Histamine H2-receptor antagonist 66357-59-3
Roxatidine Acetate HCl 93793-83-0
Rupatadine Fumarate 182349-12-8
Serotonin HCl 153-98-0
Tripelennamine HCl H1-receptor antagonist 154-69-8
genes like me logo Genes that share compounds with HRH2: view

Transcripts for HRH2 Gene

mRNA/cDNA for HRH2 Gene

(7) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HRH2 Gene

Histamine receptor H2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HRH2 Gene

No ASD Table

Relevant External Links for HRH2 Gene

GeneLoc Exon Structure for
HRH2
ECgene alternative splicing isoforms for
HRH2

Expression for HRH2 Gene

mRNA expression in normal human tissues for HRH2 Gene

mRNA differential expression in normal tissues according to GTEx for HRH2 Gene

This gene is overexpressed in Whole Blood (x30.6).

SOURCE GeneReport for Unigene cluster for HRH2 Gene Hs.247885

genes like me logo Genes that share expression patterns with HRH2: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for HRH2 Gene

Orthologs for HRH2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HRH2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC521257 35
  • 83.57 (n)
  • 80.22 (a)
HRH2 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HRH2 35
  • 87.47 (n)
  • 86.91 (a)
HRH2 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hrh2 35
  • 83.99 (n)
  • 86.03 (a)
Hrh2 16
Hrh2 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HRH2 35
  • 99.81 (n)
  • 100 (a)
HRH2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hrh2 35
  • 85.01 (n)
  • 86.59 (a)
oppossum
(Monodelphis domestica)
Mammalia HRH2 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HRH2 36
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves HRH2 35
  • 67.18 (n)
  • 62.88 (a)
HRH2 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HRH2 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hrh2 35
  • 61.64 (n)
  • 61.54 (a)
zebrafish
(Danio rerio)
Actinopterygii hrh2 35
  • 59.86 (n)
  • 60.21 (a)
HRH2 36
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6919 37
  • 37 (a)
Octbeta3R 35
  • 52.23 (n)
  • 41.2 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRNNA3 35
  • 51.52 (n)
  • 39.39 (a)
worm
(Caenorhabditis elegans)
Secernentea M03F4.3 37
  • 39 (a)
ser-5 36
  • 20 (a)
ManyToMany
ser-6 36
  • 26 (a)
ManyToMany
Species with no ortholog for HRH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HRH2 Gene

ENSEMBL:
Gene Tree for HRH2 (if available)
TreeFam:
Gene Tree for HRH2 (if available)

Paralogs for HRH2 Gene

Paralogs for HRH2 Gene

(25) SIMAP similar genes for HRH2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HRH2: view

Variants for HRH2 Gene

Sequence variations from dbSNP and Humsavar for HRH2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_009958 -
VAR_009959 -
VAR_009960 -
rs735051 -- 175,709,779(+) CTACC(C/T)GACAG utr-variant-3-prime
rs752829 -- 175,708,005(-) GGGAC(C/T)GGGAG downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HRH2 Gene

Variant ID Type Subtype PubMed ID
nsv469707 CNV Loss 16826518

Variation tolerance for HRH2 Gene

Residual Variation Intolerance Score: 15.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HRH2 Gene

HapMap Linkage Disequilibrium report
HRH2
Human Gene Mutation Database (HGMD)
HRH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HRH2 Gene

Disorders for HRH2 Gene

MalaCards: The human disease database

(25) MalaCards diseases for HRH2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
duodenal ulcer
  • curling ulcer
peptic ulcer disease
  • acute peptic ulcer with hemorrhage
gastric ulcer
  • acute gastric ulcer with haemorrhage and perforation
esophagitis
  • acute esophagitis
dyspepsia
  • dyspepsia, indigestion nos
- elite association - COSMIC cancer census association via MalaCards
Search HRH2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HRH2

Genetic Association Database (GAD)
HRH2
Human Genome Epidemiology (HuGE) Navigator
HRH2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HRH2
genes like me logo Genes that share disorders with HRH2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HRH2 Gene

Publications for HRH2 Gene

  1. Molecular cloning of the human histamine H2 receptor. (PMID: 1714721) Gantz I. … Yamada T. (Biochem. Biophys. Res. Commun. 1991) 2 3 4 23 67
  2. Hypoxemia associated with cimetidine therapy in a newborn infant. (PMID: 8863950) Kuint J. … Reichman B. (Am J Perinatol 1996) 23 25 26
  3. Roxatidine, an H(2) receptor blocker, is an estrogenic compound--experimental evidence. (PMID: 20718616) Agrawal S.S. … Alvin Jose M. (Syst Biol Reprod Med 2010) 25 26
  4. Histamine H2 receptor trafficking: role of arrestin, dynamin, and clathrin in histamine H2 receptor internalization. (PMID: 18617631) Fernandez N. … Shayo C. (Mol. Pharmacol. 2008) 3 23
  5. Agonist-induced internalization of histamine H2 receptor and activation of extracellular signal-regulated kinases are dynamin-dependent. (PMID: 18691388) Xu A.J. … Yanai K. (J. Neurochem. 2008) 3 23

Products for HRH2 Gene

Sources for HRH2 Gene

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