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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HRH2 Gene

protein-coding GIFtS: 66
GCID: GC05P175085

histamine receptor H2

Explore 69 diseases affiliated with
HRH2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Histamine Receptor H2¹ ²
Gastric Receptor I² ³
H2R² ³
HH2R² ³
Gastric Receptor 1²
Histamine H2 Receptor²

External Ids:	HGNC: 5183¹	Entrez Gene: 3274²	Ensembl: ENSG00000113749⁷	OMIM: 142703⁵	UniProtKB: P25021³

Export aliases for HRH2 gene to outside databases

Previous GC identifers: GC05P175424 GC05P175931 GC05P175045 GC05P175090 GC05P175042 GC05P170183

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HRH2:

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its

various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1

of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also

regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth

and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this

gene. (provided by RefSeq, Aug 2008)

UniProtKB/Swiss-Prot: HRH2_HUMAN, P25021

Function: The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate

gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The

activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G

protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity)

summary for HRH2:

Histamine H2 receptors are Galphas-protein-coupled receptors involved in the suppressive activities of

histamine. H2 receptors exhibit a widespread distribution and are found in the gastrointestinal tract, the

central nervous system, smooth muscle cells, endothelial cells, cardiomyocytes, immune cells and more. H2

receptors regulate various functions of histamine including heart contraction, gastric acid secretion, cell

proliferation and differentiation, and immune responses. In the immune system, H2 activation negatively

regulates basophils and mast cells, and inhibits antibody synthesis, T cell production, cell-mediated

cytolysis and cytokine production. H2 receptors are present on Th2 cells and activation increases the

synthesis of cytokines such as IL-4, Il-5, Il-10 and IL-13. Furthermore, histamine-induced T cell suppressor

activity is mediated through H2 receptors. Due to their role in gastric acid secretion, H2 receptor

overactivity is a cause of gastric ulcers, and pharmacological inhibition of these receptors is an effective

treatment for this condition. The human gene encoding the H2 receptor is localized to chromosome 5q35.3.

Gene Wiki entry for HRH2 (Histamine H2 receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_023133.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HRH2 gene promoter:
SRF AhR AML1a AP-1 SRF (504 AA) Pax-6 STAT5A AP-4 FOXC1 Zic1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HRH2 promoter sequence

Search SABiosciences Chromatin IP Primers for HRH2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HRH2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.2 Ensembl cytogenetic band: 5q35.2 HGNC cytogenetic band: 5q35

HRH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HRH2 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P175085: view genomic region (about GC identifiers)

Start:	175,085,033 bp from pter	End:	175,113,245 bp from pter
Size:	28,213 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HRH2_HUMAN, P25021 (See protein sequence)

Recommended Name: Histamine H2 receptor

Size: 359 amino acids; 40098 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Miscellaneous: Antagonists for this receptor have proven to be effective therapy for acid peptic disorders of the

gastrointestinal tract. Certain antagonists are used in the treatment of neuropsychiatric and neurological diseases

such as schizophrenia, Alzheimer disease and Parkinson disease

Secondary accessions: B5BUP7 Q14464 Q7Z5R9

Alternative splicing: 2 isoforms: P25021-1 P25021-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HRH2: NX_P25021

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P25021

HRH2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001124527.1 NP_071640.1

ENSEMBL proteins:

ENSP00000366506 ENSP00000231683

Reactome Protein details: P25021
Human Recombinant Protein Products:

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	Novus Biologicals HRH2 Protein Novus Biologicals HRH2 Lysate
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	Uscn Proteins for HRH2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	1714721

HRH2 for ontologies About GeneDecksing

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	GenScript HRH2-overexpressing Cell Line for Assay
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for HRH2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HRH2 for domains About GeneDecksing

3 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_7TM

IPR000276 GPCR_Rhodpsn

IPR000503 Histamine_H2_rcpt

Graphical View of Domain Structure for InterPro Entry P25021

ProtoNet protein and cluster: P25021

1 Blocks protein family: IPB000503 Histamine H2 receptor signature

UniProtKB/Swiss-Prot: HRH2_HUMAN, P25021

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: HRH2_HUMAN, P25021

Function: The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate

gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The

activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G

protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity)

Genatlas biochemistry entry for HRH2:

histamine H2 receptor,G protein coupled receptor superfamily,activating adenylate cyclase,stimulating gastric acid

secretion,increasing contraction of cardiac muscle

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		1 QIAGEN miScript miRNA Assays for microRNA that regulate HRH2:
		hsa-miR-30b*
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRH2

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004969	histamine receptor activity	IEA	--
GO:0005515	protein binding	--	--

HRH2 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for HRH2: Hrh2^tm1Yfks Hrh2^tm1Wtn
     4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Hrh2):

behavior/neurological

digestive/alimentary

homeostasis/metabolism

nervous system

HRH2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			GPCRs, Class A Rhodopsin-like	0.41
	GPCR ligand binding	0.75			Neuroactive ligand-receptor interaction	0.38

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Development_Ligand-independent activation of ESR1 and ESR2

Development_Ligand-independent activation of ESR1 and ESR2

1.00

Development Ligand-independent activation of ESR1 and ESR2

0.97

Transcription CREB pathway

Transcription CREB pathway

1.00

Transcription_CREB pathway

0.93

Monoamine GPCRs

Monoamine GPCRs

1.00

Amine ligand-binding receptors

0.79

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for HRH2

	Transcription CREB pathway
	Development Ligand-independent activation of ESR1 and ESR2

2 GeneGo (Thomson Reuters) Pathways for HRH2

	Development Ligand-independent activation of ESR1 and ESR2
	Transcription CREB pathway

2 BioSystems Pathways for HRH2

	GPCRs, Class A Rhodopsin-like
	Monoamine GPCRs

5/8 Reactome Pathways for HRH2 (see all 8)

	GPCR downstream signaling
	Signaling by GPCR
	GPCR ligand binding
	Class A/1 (Rhodopsin-like receptors)
	Signal Transduction

1 PharmGKB Pathway for HRH2

Proton Pump Inhibitor Pathway, Pharmacodynamics

3 Kegg Pathways (Kegg details for HRH2):

	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gastric acid secretion

HRH2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for HRH2

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

5/10 Interacting proteins for HRH2 (P25021³ ENSP00000366506⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GPRASP2	Q96D09³, ENSP00000339057⁴	I2D: score=1 STRING: ENSP00000339057
SF3A2	ENSP00000221494⁴	STRING: ENSP00000221494
GNAL	ENSP00000334051⁴	STRING: ENSP00000334051
GNAS	ENSP00000360141⁴	STRING: ENSP00000360141
HDGF	ENSP00000357189⁴	STRING: ENSP00000357189

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006955	immune response	TAS	9725260
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	9725260

HRH2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

HRH2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for HRH2 available from Tocris Bioscience About this table

Compound	Action	CAS #
HTMT dimaleate	H1 / H2 agonist	[195867-54-0]
Amthamine dihydrobromide	Highly selective standard H2 agonist	[142437-67-0]
Dimaprit dihydrochloride	Standard H2 selective agonist	[23256-33-9]
Zolantidine dimaleate	Potent, centrally active H2 antagonist	[104076-38-2]
Tiotidine	Potent, selective H2 antagonist	[69014-14-8]

3 HMDB Compounds for HRH2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Famotidine	Amfamox (see all 83)	76824-35-6	--
Histamine	1H-Imidazole-4-ethanamine (see all 27)	51-45-6	--
Ranitidine	Achedos (see all 52)	66357-59-3	--

10/11 DrugBank Compounds for HRH2 (see all 11) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Famotidine	Famotidina [Spanish] (see all 2)	76824-35-6	target	antagonist	16513821 2067140 1646056 16702624 12509588 11752352 18310651 12832840 19578661 17273750 16723495
Betazole	Ametazole (see all 4)	105-20-4	target	agonist	7213132 2886642 2892392 11752352 2874214 3661710
Nizatidine	--	76963-41-2	target	antagonist	2895808 2858133 2567267 11752352 2877081 1843561
Cimetidine	--	51481-61-9	target	antagonist	10950107 8863950 11752352 16723495
Histamine Phosphate	--	51-74-1	target	agonist	17359382 11752352 17334413
Doxepin	Doxepin Hcl (see all 5)	1668-19-5	target	antagonist	2141000 2897127
Ranitidine	Ranitidine HCL (see all 3)	66357-35-5	target	antagonist	7554999 11752352
Epinastine	Epinastina [Spanish] (see all 2)	80012-43-7	target	antagonist	16131920
Methantheline	Banthine Bromide (see all 7)	5818-17-7	target	antagonist	6116801
Metiamide	Methiamide (see all 3)	34839-70-8	target	antagonist	7725982

10/100 Novoseek chemical compound relationships for HRH2 gene (see all 100) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
histamine	93.1	496	9014481 (12), 1971799 (6), 11521983 (5), 1972605 (5) (see all 99)
ranitidine	92.1	50	14671421 (3), 11521983 (2), 1974182 (1), 2199130 (1) (see all 43)
cimetidine	91.4	66	7911673 (2), 15014995 (2), 11521983 (2), 1974182 (1) (see all 59)
famotidine	91	34	1974182 (1), 2199130 (1), 10222548 (1), 11998377 (1) (see all 30)
nizatidine	88.8	21	1967857 (2), 1974182 (1), 2199130 (1), 7780679 (1) (see all 15)
tiotidine	87	2	12869657 (2)
amthamine	85.9	5	18617631 (1), 8147269 (1), 7781673 (1), 7721041 (1) (see all 5)
roxatidine	84.6	4	1717223 (1), 16702623 (1), 10462360 (1), 1354631 (1)
omeprazole	81.8	37	8884305 (3), 9513825 (2), 1978433 (2), 8023719 (2) (see all 31)
sucralfate	80.6	15	1974182 (1), 15693983 (1), 9010645 (1), 9504939 (1) (see all 14)

Search CenterWatch for drugs/clinical trials and news about HRH2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HRH2 gene (2 alternative transcripts):

NM_001131055.1 NM_022304.2

Unigene Cluster for HRH2:

Histamine receptor H2

Hs.247885 [show with all ESTs]

Unigene Representative Sequence: NM_022304

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000377291(uc003mdc.4) ENST00000231683(uc003mdd.2)

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HRH2

Additional cDNA sequence:

AB451483.1 AY136744.1 BC054510.2

2 DOTS entries:

DT.101980161 DT.75155249

14 AceView cDNA sequences:

BF448672 AY136744 NM_022304 BC054510 BX282428 BF448622 BU171745 AI927210

BG002844 CF147823 AB023487 CD631354 CD631353 BF360825

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HRH2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCTGCCATC

About this image
See HRH2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HRH2

SOURCE GeneReport for Unigene cluster: Hs.247885

SABiosciences Expression via Pathway-Focused PCR Array including HRH2:

G Protein Coupled Receptors 384HT in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRH2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for HRH2 gene from 6/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Hrh2^{1 , 5}	histamine receptor H2^{1, 5}	83.06(n)¹ 84.7(a)¹		13 (28.40 cM)⁵ 15466¹ NM_001010973.2¹ NP_001010973.1¹ 54192129⁵
chicken (Gallus gallus)	Aves	HRH2¹	histamine receptor H2	66.87(n) 62.61(a)		427635 XM_425208.2 XP_425208.2
lizard (Anolis carolinensis)	Reptilia	HRH2⁶	--	56(a)	1 ↔ 1	GL343477.1(347249-348343)
zebrafish (Danio rerio)	Actinopterygii	hrh2¹	histamine receptor H2	59.86(n) 60.21(a)		735303 NM_001045338.1 NP_001038803.1
fruit fly (Drosophila melanogaster)	Insecta	CG6919³	G-protein coupled receptor protein signaling pathway more	37(a)		94B2 --
worm (Caenorhabditis elegans)	Secernentea	M03F4.3³ ser-7¹	G-protein coupled receptor³ Protein SER-7¹	39(a)³ 46.67(n)¹ 37.14(a)¹		X(4985611-4990413)³ 180565¹ NM_171637.3¹ NP_741730.1¹

ENSEMBL Gene Tree for HRH2 (if available)
TreeFam Gene Tree for HRH2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HRH2 gene

TAAR6² HTR2A² HTR6² TAAR2² ADRB1² TAAR8² HTR2B² DRD1²

HTR2C² TAAR1² ADRB2² HTR4² DRD5² ADRB3² TAAR5²

18/25 SIMAP similar genes for HRH2 using alignment to 1 protein entry: HRH2_HUMAN(see all similar genes):

HTR4 HTR4B ADRB2 TAAR5 DRD1 TAAR1

ADORA2B ADRA1A ADRA1B HTR5A ADRA1D TAAR2

TAAR6 ADRB1 HTR7 TAAR3 TAAR8 TAAR9

HRH2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs13176428^1,2	C,F,	--	175083166(+)	`TGGGCG/ATGGTG`	1	--	us2k¹		3		NA	6
rs183817729^1,2		--	175083195(+)	`AGCTAC/GTCGGG`	1	--	us2k¹		0	--	--	--	--
rs2913220^1,2	C,F,	--	175083217(-)	`agcaaG/Atctcc`	1	--	us2k¹		7		NA WA CSA	12
rs60931791^1,2	C	--	175083310(+)	`ATAAA-/TAAA ATAAA`	1	--	us2k¹		1		NA	2
rs187458505^1,2		--	175083354(+)	`ATAAAA/TAAAAT`	1	--	us2k¹		0	--	--	--	--
rs151120939^1,2		--	175083355(+)	`TAAATA/TAAATA`	1	--	us2k¹		0	--	--	--	--
rs141083488^1,2		--	175083467(+)	`TTAGAA/TAAGTT`	1	--	us2k¹		0	--	--	--	--
rs149879189^1,2		--	175083674(+)	`GGTGGC/TTCTTG`	1	--	us2k¹		0	--	--	--	--
rs2963854^1,2	C,F,H,	--	175083754(+)	`GTCACA/GGGAGG`	1	--	us2k¹		25		NS EA NA WA CSA	2354
rs112369019^1,2		--	175083811(+)	`AGAGAC/TTCTCT`	1	--	us2k¹		1		CSA	2

HapMap Linkage Disequilibrium report for HRH2 (175085033 - 175113245 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for HRH2
1 CNV: 2092
Human Gene Mutation Database (HGMD): HRH2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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HRH2 for disorders           About GeneDecksing

OMIM gene information: 142703    OMIM disorders: --

20/69 diseases for HRH2 (see all 69):    About MalaCards

gastric ulcer zollinger-ellison syndrome gastroesophageal reflux disease meckel's diverticulum

aspiration pneumonitis duodenal ulcer drug psychosis peptic ulcer

non-hodgkin lymphoma juvenile rheumatoid arthritis ventricular fibrillation interstitial nephritis

duodenitis allergic rhinitis hodgkin's lymphoma bronchial asthma

bronchogenic carcinoma gastroenteritis urticaria acute lymphoblastic leukemia

5 diseases from the University of Copenhagen DISEASES database for HRH2:

Peptic ulcer Esophagitis Gastroesophageal reflux disease Dyspepsia

Gastritis

10/53 Novoseek disease relationships for HRH2 gene (see all 53) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
peptic ulcer	79.1	21	1834730 (1), 10222548 (1), 7527761 (1), 11510196 (1) (see all 20)
stress ulcer	77.3	7	19318661 (1), 17592004 (1), 1358868 (1), 8701013 (1) (see all 7)
duodenal ulcer	73.9	18	7525198 (2), 14567455 (2), 9121092 (2), 1600048 (1) (see all 14)
zollinger-ellison syndrome	73.5	2	7949462 (1), 8104773 (1)
ulcer	72.2	27	1347323 (1), 1356644 (1), 7881012 (1), 9068463 (1) (see all 26)
gastric ulcer	71	19	1971799 (3), 7525198 (2), 10606307 (2), 1359134 (2) (see all 14)
esophagitis	64.7	12	9513825 (2), 7601011 (1), 9165690 (1), 10826019 (1) (see all 11)
gastroesophageal reflux disease	60.9	4	8480563 (1), 9165690 (1), 12664775 (1), 15683433 (1)
reflux	59.9	9	8961846 (1), 18600389 (1), 7601011 (1), 15932360 (1) (see all 7)
duodenal ulcer disease	58.8	1	8284002 (1)

Genetic Association Database (GAD): HRH2
Human Genome Epidemiology (HuGE) Navigator: HRH2 (10 documents)

Export disorders for HRH2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for HRH2 gene, integrated from 9 sources (see all 487):
(articles sorted by number of sources associating them with HRH2)

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Molecular cloning of the human histamine H2 receptor. (PubMed id 1714721)^{1, 2, 3, 9} Gantz I.... Yamada T. (1991)
Human histamine H2 receptor gene: multiple transcription initiation and tissue-specific expression. (PubMed id 10371214)^{1, 2, 9} Murakami H.... Futai M. (1999)
Polymorphisms of high-affinity IgE receptor and histamine-related genes in patients with ASA-induced urticaria/angioedema. (PubMed id 15953854)^{1, 4} Choi J.H....Park H.S. (2005)
Investigation of promoter variants of the histamine 1 and 2 receptors in schizophrenia and clozapine response. (PubMed id 12429384)^{1, 4} Mancama D....Kerwin R. (2002)
Novel insights into histamine H2 receptor biology. (PubMed id 9374694)^{1, 2} DelValle J. and Gantz I. (1997)
Allelic variations of the human histamine H2 receptor gene. (PubMed id 8817552)^{1, 2} Orange P.R.... Pearson R.C.A. (1996)
Identification of the promoter region of the human histamine H2- receptor gene. (PubMed id 7755641)^{1, 2} Nishi T.... Futai M. (1995)
Histamine H2 receptor desensitization: involvement of a select array of G protein-coupled receptor kinases. (PubMed id 11641433)^{1, 9} Shayo C....Davio C. (2001)
Histamine H2 receptor trafficking: role of arrestin, dynamin, and clathrin in histamine H2 receptor internalization. (PubMed id 18617631)^{1, 9} Fernandez N....Shayo C. (2008)
The guinea pig histamine H2 receptor: gene cloning, tissue expression and chromosomal localization of its human counterpart. (PubMed id 7794271)^{1, 9} Traiffort E....Ruat M. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3274	HGNC: 5183	AceView: HRH2	Ensembl:ENSG00000113749	euGenes: HUgn3274
ECgene: HRH2	Kegg: 3274	H-InvDB: HRH2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for HRH2	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/H2_receptor

Intellectual Property for HRH2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for HRH2 gene:
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GeneCards and IP:
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histamine receptor H2

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