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Aliases for HRH2 Gene

Aliases for HRH2 Gene

  • Histamine Receptor H2 2 3 5
  • Gastric Receptor I 3 4
  • HH2R 3 4
  • H2R 3 4
  • Histamine H2 Receptor 3
  • Gastric Receptor 1 3

External Ids for HRH2 Gene

Previous GeneCards Identifiers for HRH2 Gene

  • GC05P175424
  • GC05P175931
  • GC05P175045
  • GC05P175090
  • GC05P175042
  • GC05P175085
  • GC05P170183

Summaries for HRH2 Gene

Entrez Gene Summary for HRH2 Gene

  • Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

GeneCards Summary for HRH2 Gene

HRH2 (Histamine Receptor H2) is a Protein Coding gene. Diseases associated with HRH2 include Duodenal Ulcer and Peptic Ulcer Disease. Among its related pathways are Signaling by GPCR and Development Ligand-independent activation of ESR1 and ESR2. GO annotations related to this gene include G-protein coupled receptor activity and histamine receptor activity. An important paralog of this gene is DRD1.

UniProtKB/Swiss-Prot for HRH2 Gene

  • The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity).

Tocris Summary for HRH2 Gene

  • Histamine H2 receptors are Galphas-protein-coupled receptors involved in the suppressive activities of histamine. H2 receptors exhibit a widespread distribution and are found in the gastrointestinal tract, the central nervous system, smooth muscle cells and endothelial cells.

Gene Wiki entry for HRH2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HRH2 Gene

Genomics for HRH2 Gene

Regulatory Elements for HRH2 Gene

Enhancers for HRH2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F175686 1.3 FANTOM5 Ensembl ENCODE 13.5 +31.3 31349 4.9 CTCF L3MBTL2 NRF1 MAX ZIC2 ZFHX2 ZNF512 GLIS1 MYC SPI1 HRH2 LOC105377743
GH05F175670 0.6 FANTOM5 Ensembl 14.3 +13.2 13206 2.0 REST HRH2 LOC105377743
GH05F175692 1.4 FANTOM5 Ensembl ENCODE 4.1 +37.2 37229 4.4 PKNOX1 ZBTB40 ZNF2 RAD21 ETS1 FOS ETV6 KDM4B CREM ZNF654 HRH2 LOC105377743
GH05F175657 0.9 ENCODE 0.8 +0.4 389 1.1 ZNF133 GLI4 GLIS2 ZNF366 KLF7 EGR2 ZNF263 SP3 ZNF843 ZNF585B HRH2 LOC105377743
GH05F175650 0.8 Ensembl ENCODE 0.8 -4.4 -4396 5.2 ZNF366 ZNF512 CEBPB PRDM1 HRH2 GC05M175577
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HRH2 on UCSC Golden Path with GeneCards custom track

Promoters for HRH2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001416831 504 1401 ZNF133 GLI4 GLIS2 ZNF366 KLF7 EGR2 SP3 ZNF843 ZNF585B GLIS1

Genomic Location for HRH2 Gene

Chromosome:
5
Start:
175,657,796 bp from pter
End:
175,710,756 bp from pter
Size:
52,961 bases
Orientation:
Plus strand

Genomic View for HRH2 Gene

Genes around HRH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HRH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HRH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HRH2 Gene

Proteins for HRH2 Gene

  • Protein details for HRH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25021-HRH2_HUMAN
    Recommended name:
    Histamine H2 receptor
    Protein Accession:
    P25021
    Secondary Accessions:
    • B5BUP7
    • Q14464
    • Q7Z5R9

    Protein attributes for HRH2 Gene

    Size:
    359 amino acids
    Molecular mass:
    40098 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Antagonists for this receptor have proven to be effective therapy for acid peptic disorders of the gastrointestinal tract. Certain antagonists are used in the treatment of neuropsychiatric and neurological diseases such as schizophrenia, Alzheimer disease and Parkinson disease.

    Alternative splice isoforms for HRH2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HRH2 Gene

Post-translational modifications for HRH2 Gene

  • Glycosylation at Asn 4
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HRH2 Gene

Domains & Families for HRH2 Gene

Gene Families for HRH2 Gene

Protein Domains for HRH2 Gene

Suggested Antigen Peptide Sequences for HRH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P25021

UniProtKB/Swiss-Prot:

HRH2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HRH2: view

Function for HRH2 Gene

Molecular function for HRH2 Gene

GENATLAS Biochemistry:
histamine H2 receptor,G protein coupled receptor superfamily,activating adenylate cyclase,stimulating gastric acid secretion,increasing contraction of cardiac muscle
UniProtKB/Swiss-Prot Function:
The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity).

Gene Ontology (GO) - Molecular Function for HRH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004969 histamine receptor activity IEA --
genes like me logo Genes that share ontologies with HRH2: view
genes like me logo Genes that share phenotypes with HRH2: view

Animal Models for HRH2 Gene

MGI Knock Outs for HRH2:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HRH2 Gene

Localization for HRH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HRH2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HRH2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for HRH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane TAS 1714721
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HRH2: view

Pathways & Interactions for HRH2 Gene

genes like me logo Genes that share pathways with HRH2: view

Gene Ontology (GO) - Biological Process for HRH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001697 histamine-induced gastric acid secretion IEA --
GO:0001698 gastrin-induced gastric acid secretion IEA --
GO:0003382 epithelial cell morphogenesis IEA --
GO:0006955 immune response TAS 9725260
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with HRH2: view

No data available for SIGNOR curated interactions for HRH2 Gene

Drugs & Compounds for HRH2 Gene

(168) Drugs for HRH2 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ranitidine Approved Pharma Antagonist, antagonist, Target Histamine H2-receptor antagonist 80
Cimetidine Approved Pharma Inhibition, Inhibitor, antagonist, Target H2 receptor antagonist, H2 antagonist, I1 agonist 70
Famotidine Approved Pharma antagonist, Target Histamine H2-receptor antagonist 59
Nizatidine Approved Pharma antagonist, Target 9
Histamine Phosphate Approved Pharma Target, agonist 1033

(28) Additional Compounds for HRH2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for HRH2 Gene

Compound Action Cas Number
Amthamine dihydrobromide Highly selective standard H2 agonist 142457-00-9
Dimaprit dihydrochloride Standard H2 selective agonist 23256-33-9
HTMT dimaleate H1 / H2 agonist 195867-54-0
Tiotidine Potent, selective H2 antagonist 69014-14-8
Zolantidine dimaleate Potent, centrally active H2 antagonist 104076-39-3

(88) ApexBio Compounds for HRH2 Gene

Compound Action Cas Number
(R)-(-)-α-Methylhistamine dihydrobromide 868698-49-1
(S)-(+)-α-Methylhistamine dihydrobromide 75614-93-6
2-Pyridylethylamine dihydrochloride 3343-39-3
Alcaftadine 147084-10-4
Aminopotentidine 140873-26-3
Amthamine dihydrobromide 142457-00-9
Astemizole 68844-77-9
Azatadine 3964-81-6
Azatadine dimaleate 3978-86-7
Azelastine HCl 79307-93-0
Benztropine mesylate 132-17-2
Bepotastine Besilate 190786-44-8
Betahistine 2HCl 5579-84-0
Bilastine 202189-78-4
Brompheniramine hydrogen maleate 980-71-2
Buclizine HCl 129-74-8
Carcinine ditrifluoroacetate 56897-53-1
Cetirizine Antihistamine 83881-51-0
Cetirizine DiHCl H1 receptor inverse agonist 83881-52-1
Chlorpheniramine Maleate 113-92-8
Cimetidine H2 receptor antagonist 51481-61-9
Ciproxifan Histamine H3-receptor antagonist 184025-18-1
Ciproxifan maleate 184025-19-2
Clemastine Fumarate 14976-57-9
Clemizole hydrochloride H1 histamine receptor antagonist 1163-36-6
Clobenpropit dihydrobromide 145231-35-2
Conessine 546-06-5
Cyclizine 2HCl 5897-18-7
Cyproheptadine hydrochloride 969-33-5
Decloxizine 3733-63-9
Decloxizine dihydrochloride 13073-96-6
Desloratadine 100643-71-8
Dimaprit dihydrochloride 23256-33-9
DPPE fumarate 1185241-83-1
Ebrotidine H2-receptor antagonist,competitive 100981-43-9
Epinastine HCl 108929-04-0
Famotidine Histamine H2-receptor antagonist 76824-35-6
Fexofenadine HCl 153439-40-8
GT 2016 152241-24-2
Histamine 2HCl 56-92-8
Histamine Phosphate 51-74-1
HTMT dimaleate 195867-54-0
Hydroxyzine 68-88-2
Hydroxyzine 2HCl 2192-20-3
ICI 162,846 84545-30-2
Imetit dihydrobromide 32385-58-3
Immepip dihydrobromide 164391-47-3
Immethridine dihydrobromide 699020-93-4
Impentamine dihydrobromide 149629-70-9
Iodophenpropit dihydrobromide 145196-87-8
JNJ 10181457 dihydrochloride 544707-20-2
JNJ 10191584 maleate 869497-75-6
JNJ 5207852 dihydrochloride 398473-34-2
JNJ-7777120 Histamine H4 receptor antagonist 459168-41-3
Ketotifen Fumarate 34580-14-8
Lafutidine 118288-08-7
LED209 Highly selective for histidine sensor kinase QseC 245342-14-7
Levodropropizine Histamine receptor inhibitor,cough suppressant 99291-25-5
Lidocaine Anasthetic and class Ib antiarrhythmic agent 137-58-6
Loratadine Peripheral HH1R antagonist 79794-75-5
Mepyramine maleate 59-33-6
Methimepip dihydrobromide 817636-54-7
Metiamide Histamine H2-receptor antagonist 34839-70-8
Mianserin 24219-97-4
Mianserin HCl 5-HT2 receptor antagonist 21535-47-7
Mizolastine 108612-45-9
Nizatidine 76963-41-2
Nα-Methylhistamine dihydrochloride 16503-22-3
Olopatadine HCl Histamine blocker 140462-76-6
Pemirolast potassium 100299-08-9
Pitolisant Nonimidazole inverse agonist 362665-56-3
Pitolisant hydrochloride Nonimidazole inverse agonist 903576-44-3
Pitolisant oxalate Nonimidazole inverse agonist 362665-57-4
Proxyfan oxalate 177708-09-7
Ranitidine Histamine H2-receptor antagonist 66357-59-3
ROS 234 dioxalate 184576-87-2
Roxatidine Acetate HCl 93793-83-0
Rupatadine Fumarate 182349-12-8
Serotonin HCl 153-98-0
Thioperamide 106243-16-7
Tiotidine 69014-14-8
trans-Triprolidine hydrochloride 550-70-9
Tripelennamine HCl H1-receptor antagonist 154-69-8
VUF 10460 1028327-66-3
VUF 5681 dihydrobromide 639089-06-8
VUF 8430 dihydrobromide 100130-32-3
Zaltidine H2-receptor antagonist 85604-00-8
Zolantidine dimaleate 104076-39-3
genes like me logo Genes that share compounds with HRH2: view

Transcripts for HRH2 Gene

mRNA/cDNA for HRH2 Gene

Unigene Clusters for HRH2 Gene

Histamine receptor H2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HRH2 Gene

No ASD Table

Relevant External Links for HRH2 Gene

GeneLoc Exon Structure for
HRH2
ECgene alternative splicing isoforms for
HRH2

Expression for HRH2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HRH2 Gene

mRNA differential expression in normal tissues according to GTEx for HRH2 Gene

This gene is overexpressed in Whole Blood (x30.6).

NURSA nuclear receptor signaling pathways regulating expression of HRH2 Gene:

HRH2

SOURCE GeneReport for Unigene cluster for HRH2 Gene:

Hs.247885
genes like me logo Genes that share expression patterns with HRH2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for HRH2 Gene

Orthologs for HRH2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HRH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HRH2 34 35
  • 99.81 (n)
dog
(Canis familiaris)
Mammalia HRH2 34 35
  • 87.47 (n)
rat
(Rattus norvegicus)
Mammalia Hrh2 34
  • 85.01 (n)
mouse
(Mus musculus)
Mammalia Hrh2 34 16 35
  • 83.99 (n)
cow
(Bos Taurus)
Mammalia LOC521257 34
  • 83.57 (n)
HRH2 35
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HRH2 35
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HRH2 35
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves HRH2 34 35
  • 67.18 (n)
lizard
(Anolis carolinensis)
Reptilia HRH2 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hrh2 34
  • 61.64 (n)
zebrafish
(Danio rerio)
Actinopterygii hrh2 34
  • 59.86 (n)
HRH2 35
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Octbeta3R 34
  • 52.23 (n)
CG6919 36
  • 37 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRNNA3 34
  • 51.52 (n)
worm
(Caenorhabditis elegans)
Secernentea M03F4.3 36
  • 39 (a)
ser-6 35
  • 26 (a)
ManyToMany
ser-5 35
  • 20 (a)
ManyToMany
Species where no ortholog for HRH2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HRH2 Gene

ENSEMBL:
Gene Tree for HRH2 (if available)
TreeFam:
Gene Tree for HRH2 (if available)

Paralogs for HRH2 Gene

Paralogs for HRH2 Gene

(25) SIMAP similar genes for HRH2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HRH2: view

Variants for HRH2 Gene

Sequence variations from dbSNP and Humsavar for HRH2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10036740 -- 175,701,157(+) aaacc(A/G)aggct intron-variant
rs10037322 -- 175,701,414(+) ATGGT(A/C)GGACC intron-variant
rs10037326 -- 175,701,488(+) ATTGC(C/G)GCTGT intron-variant
rs10037879 -- 175,707,504(+) AGACA(C/G)TAAGT intron-variant
rs10038191 -- 175,702,999(+) aacta(C/T)aaaga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HRH2 Gene

Variant ID Type Subtype PubMed ID
nsv469707 CNV loss 16826518
nsv600335 CNV loss 21841781
nsv600336 CNV loss 21841781

Variation tolerance for HRH2 Gene

Residual Variation Intolerance Score: 15.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HRH2 Gene

Human Gene Mutation Database (HGMD)
HRH2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HRH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HRH2 Gene

Disorders for HRH2 Gene

MalaCards: The human disease database

(25) MalaCards diseases for HRH2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
duodenal ulcer
  • curling ulcer
peptic ulcer disease
  • acute peptic ulcer with hemorrhage
gastric ulcer
  • acute gastric ulcer with haemorrhage and perforation
zollinger-ellison syndrome
  • gastrinoma
gastroesophageal reflux
  • gastroesophageal reflux disease
- elite association - COSMIC cancer census association via MalaCards
Search HRH2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HRH2

Genetic Association Database (GAD)
HRH2
Human Genome Epidemiology (HuGE) Navigator
HRH2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HRH2
genes like me logo Genes that share disorders with HRH2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HRH2 Gene

Publications for HRH2 Gene

  1. Molecular cloning of the human histamine H2 receptor. (PMID: 1714721) Gantz I. … Yamada T. (Biochem. Biophys. Res. Commun. 1991) 2 3 4 22 64
  2. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PMID: 20602615) RuaA+o G. … Wu A.H. (Pharmacogenomics 2010) 3 46 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. High-throughput chemiluminometric genotyping of single nucleotide polymorphisms of histamine, serotonin, and adrenergic receptor genes. (PMID: 19026982) Toubanaki D.K. … Flordellis C.S. (Anal. Biochem. 2009) 3 46 64
  5. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PMID: 19156168) Need A.C. … Goldstein D.B. (Eur. J. Hum. Genet. 2009) 3 46 64

Products for HRH2 Gene

Sources for HRH2 Gene

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