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Aliases for HRH2 Gene

Aliases for HRH2 Gene

  • Histamine Receptor H2 2 3
  • Gastric Receptor I 3 4
  • HH2R 3 4
  • H2R 3 4
  • Histamine H2 Receptor 3
  • Gastric Receptor 1 3

External Ids for HRH2 Gene

Previous GeneCards Identifiers for HRH2 Gene

  • GC05P175424
  • GC05P175931
  • GC05P175045
  • GC05P175090
  • GC05P175042
  • GC05P175085
  • GC05P170183

Summaries for HRH2 Gene

Entrez Gene Summary for HRH2 Gene

  • Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

GeneCards Summary for HRH2 Gene

HRH2 (Histamine Receptor H2) is a Protein Coding gene. Diseases associated with HRH2 include duodenal ulcer and gastric ulcer. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include histamine receptor activity. An important paralog of this gene is TAAR9.

UniProtKB/Swiss-Prot for HRH2 Gene

  • The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity).

Tocris Summary for HRH2 Gene

  • Histamine H2 receptors are Galphas-protein-coupled receptors involved in the suppressive activities of histamine. H2 receptors exhibit a widespread distribution and are found in the gastrointestinal tract, the central nervous system, smooth muscle cells, endothelial cells, cardiomyocytes, immune cells and more. H2 receptors regulate various functions of histamine including heart contraction, gastric acid secretion, cell proliferation and differentiation, and immune responses. In the immune system, H2 activation negatively regulates basophils and mast cells, and inhibits antibody synthesis, T cell production, cell-mediated cytolysis and cytokine production. H2 receptors are present on Th2 cells and activation increases the synthesis of cytokines such as IL-4, Il-5, Il-10 and IL-13. Furthermore, histamine-induced T cell suppressor activity is mediated through H2 receptors. Due to their role in gastric acid secretion, H2 receptor overactivity is a cause of gastric ulcers, and pharmacological inhibition of these receptors is an effective treatment for this condition. The human gene encoding the H2 receptor is localized to chromosome 5q35.3.

Gene Wiki entry for HRH2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HRH2 Gene

Genomics for HRH2 Gene

Regulatory Elements for HRH2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HRH2 Gene

175,657,844 bp from pter
175,709,236 bp from pter
51,393 bases
Plus strand

Genomic View for HRH2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HRH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HRH2 Gene

Proteins for HRH2 Gene

  • Protein details for HRH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Histamine H2 receptor
    Protein Accession:
    Secondary Accessions:
    • B5BUP7
    • Q14464
    • Q7Z5R9

    Protein attributes for HRH2 Gene

    359 amino acids
    Molecular mass:
    40098 Da
    Quaternary structure:
    No Data Available
    • Antagonists for this receptor have proven to be effective therapy for acid peptic disorders of the gastrointestinal tract. Certain antagonists are used in the treatment of neuropsychiatric and neurological diseases such as schizophrenia, Alzheimer disease and Parkinson disease

    Alternative splice isoforms for HRH2 Gene


neXtProt entry for HRH2 Gene

Proteomics data for HRH2 Gene at MOPED

Post-translational modifications for HRH2 Gene

  • Glycosylation at Asn4
  • Modification sites at PhosphoSitePlus

Other Protein References for HRH2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HRH2 Gene

Domains for HRH2 Gene

Gene Families for HRH2 Gene

  • HRH :GPCR / Class A : Histamine receptors

Protein Domains for HRH2 Gene

Suggested Antigen Peptide Sequences for HRH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P25021
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HRH2: view

Function for HRH2 Gene

Molecular function for HRH2 Gene

GENATLAS Biochemistry: histamine H2 receptor,G protein coupled receptor superfamily,activating adenylate cyclase,stimulating gastric acid secretion,increasing contraction of cardiac muscle
UniProtKB/Swiss-Prot Function: The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity).

Gene Ontology (GO) - Molecular Function for HRH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001588 NOT dopamine neurotransmitter receptor activity, coupled via Gs IBA --
GO:0004930 G-protein coupled receptor activity --
GO:0004969 histamine receptor activity IEA --
GO:0035240 NOT dopamine binding IBA --
genes like me logo Genes that share ontologies with HRH2: view
genes like me logo Genes that share phenotypes with HRH2: view

Animal Models for HRH2 Gene

MGI Knock Outs for HRH2:

miRNA for HRH2 Gene

miRTarBase miRNAs that target HRH2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HRH2 Gene

Localization for HRH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HRH2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for HRH2 Gene COMPARTMENTS Subcellular localization image for HRH2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for HRH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1714721
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with HRH2: view

Pathways for HRH2 Gene

genes like me logo Genes that share pathways with HRH2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for HRH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001696 gastric acid secretion --
GO:0001697 histamine-induced gastric acid secretion IBA --
GO:0001698 gastrin-induced gastric acid secretion IEA --
GO:0001963 synaptic transmission, dopaminergic IBA --
GO:0003382 epithelial cell morphogenesis IEA --
genes like me logo Genes that share ontologies with HRH2: view

Compounds for HRH2 Gene

(5) Tocris Compounds for HRH2 Gene

Compound Action Cas Number
Amthamine dihydrobromide Highly selective standard H2 agonist [142457-00-9]
Dimaprit dihydrochloride Standard H2 selective agonist [23256-33-9]
HTMT dimaleate H1 / H2 agonist [195867-54-0]
Ranitidine hydrochloride Selective H2 antagonist [66357-59-3]
Zolantidine dimaleate Potent, centrally active H2 antagonist [104076-39-3]

(3) HMDB Compounds for HRH2 Gene

Compound Synonyms Cas Number PubMed IDs
  • Amfamox
  • 1H-Imidazole-4-ethanamine
  • Achedos

(12) Drugbank Compounds for HRH2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
65576-45-6 target antagonist
  • Ametazole
105-20-4 target agonist
51481-61-9 target antagonist
1668-19-5 target antagonist
  • Epinastina [Spanish]
80012-43-7 target antagonist

(10) IUPHAR Ligand for HRH2 Gene

Ligand Type Action Affinity Pubmed IDs
[3H]tiotidine Antagonist Antagonist 8.7
arpromidine Agonist Full agonist 8
impromidine Agonist Full agonist 7.2
ranitidine Antagonist Antagonist 7.1
UR-PG136 Agonist Full agonist 7
amthamine Agonist Full agonist 6.4
UR-PG146 Agonist Full agonist 6
burimamide Agonist Full agonist 5.7
clobenpropit Antagonist Antagonist 5.2
ABT-239 Antagonist Inverse agonist 5.2

(100) Novoseek inferred chemical compound relationships for HRH2 Gene

Compound -log(P) Hits PubMed IDs
histamine 93.1 198
ranitidine 92.1 46
cimetidine 91.4 62
famotidine 91 30
nizatidine 88.8 16
genes like me logo Genes that share compounds with HRH2: view

Transcripts for HRH2 Gene

mRNA/cDNA for HRH2 Gene

(14) Selected AceView cDNA sequences:
(7) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HRH2 Gene

Histamine receptor H2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HRH2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HRH2 Gene

No ASD Table

Relevant External Links for HRH2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HRH2 Gene

mRNA expression in normal human tissues for HRH2 Gene

mRNA differential expression in normal tissues according to GTEx for HRH2 Gene

This gene is overexpressed in Whole Blood (30.6).

SOURCE GeneReport for Unigene cluster for HRH2 Gene Hs.247885

genes like me logo Genes that share expressions with HRH2: view

In Situ Assay Products

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for HRH2 Gene

Orthologs for HRH2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HRH2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HRH2 35
  • 99.81 (n)
  • 100 (a)
HRH2 36
  • 100 (a)
(Bos Taurus)
Mammalia HRH2 36
  • 80 (a)
LOC521257 35
  • 83.57 (n)
  • 80.22 (a)
(Canis familiaris)
Mammalia HRH2 35
  • 87.47 (n)
  • 86.91 (a)
HRH2 36
  • 84 (a)
(Mus musculus)
Mammalia Hrh2 35
  • 83.99 (n)
  • 86.03 (a)
Hrh2 16
Hrh2 36
  • 79 (a)
(Monodelphis domestica)
Mammalia HRH2 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia HRH2 36
  • 55 (a)
(Rattus norvegicus)
Mammalia Hrh2 35
  • 85.01 (n)
  • 86.59 (a)
(Gallus gallus)
Aves HRH2 35
  • 67.18 (n)
  • 62.88 (a)
HRH2 36
  • 56 (a)
(Anolis carolinensis)
Reptilia HRH2 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hrh2 35
  • 61.64 (n)
  • 61.54 (a)
(Danio rerio)
Actinopterygii hrh2 35
  • 59.86 (n)
  • 60.21 (a)
HRH2 36
  • 50 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRNNA3 35
  • 51.52 (n)
  • 39.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta Octbeta3R 35
  • 52.23 (n)
  • 41.2 (a)
CG6919 37
  • 37 (a)
(Caenorhabditis elegans)
Secernentea ser-5 36
  • 20 (a)
ser-6 36
  • 26 (a)
M03F4.3 37
  • 39 (a)
Species with no ortholog for HRH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HRH2 Gene

Gene Tree for HRH2 (if available)
Gene Tree for HRH2 (if available)

Paralogs for HRH2 Gene

Paralogs for HRH2 Gene

Selected SIMAP similar genes for HRH2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HRH2: view

Variants for HRH2 Gene

Sequence variations from dbSNP and Humsavar for HRH2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs594623 -- 175,681,450(-) TGAGT(A/G)TGTGC intron-variant, upstream-variant-2KB
rs600812 -- 175,699,246(-) GGACA(C/G)AAAGT intron-variant
rs601766 -- 175,698,998(-) TTGAA(A/G)GAGAC intron-variant
rs608054 -- 175,695,162(-) GTCAA(C/T)GTGCT intron-variant
rs615154 -- 175,698,293(-) TAGGC(A/G)AAACG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HRH2 Gene

Variant ID Type Subtype PubMed ID
nsv469707 CNV Loss 16826518

Relevant External Links for HRH2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HRH2 Gene

Disorders for HRH2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (14) Diseases for HRH2 Gene including...

Search for HRH2 Gene in MalaCards »

(5) University of Copenhagen DISEASES for HRH2 Gene

(53) Novoseek inferred disease relationships for HRH2 Gene

Disease -log(P) Hits PubMed IDs
peptic ulcer 79.1 20
stress ulcer 77.3 7
duodenal ulcer 73.9 17
zollinger-ellison syndrome 73.5 2
ulcer 72.2 26

Relevant External Links for HRH2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HRH2: view

No data available for UniProtKB/Swiss-Prot for HRH2 Gene

Publications for HRH2 Gene

  1. Molecular cloning of the human histamine H2 receptor. (PMID: 1714721) Gantz I. … Yamada T. (Biochem. Biophys. Res. Commun. 1991) 2 3 4 23
  2. Human histamine H2 receptor gene: multiple transcription initiation and tissue-specific expression. (PMID: 10371214) Murakami H. … Futai M. (FEBS Lett. 1999) 3 4 23
  3. Visualization of agonist-induced internalization of histamine H2 receptors. (PMID: 7575521) Smit M.J. … Leurs R. (Biochem. Biophys. Res. Commun. 1995) 3 23
  4. Histamine H2 receptor gene variants: lack of association with schizophrenia. (PMID: 10822343) Ito C. … Arrang J.M. (Mol. Psychiatry 2000) 23 48
  5. Histamine H2 receptor desensitization: involvement of a select array of G protein-coupled receptor kinases. (PMID: 11641433) Shayo C. … Davio C. (Mol. Pharmacol. 2001) 3 23

Products for HRH2 Gene

Sources for HRH2 Gene

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