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Aliases for HRH1 Gene

Aliases for HRH1 Gene

  • Histamine Receptor H1 2 3
  • HH1R 3 4
  • H1R 3 4
  • Histamine Receptor, Subclass H1 3
  • Histamine H1 Receptor 3
  • HisH1 3
  • H1-R 3

External Ids for HRH1 Gene

Previous GeneCards Identifiers for HRH1 Gene

  • GC03P011223
  • GC03P011270
  • GC03P011271
  • GC03P011272

Summaries for HRH1 Gene

Entrez Gene Summary for HRH1 Gene

  • Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2015]

GeneCards Summary for HRH1 Gene

HRH1 (Histamine Receptor H1) is a Protein Coding gene. Diseases associated with HRH1 include cholinergic urticaria and chronic rhinitis. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and histamine receptor activity. An important paralog of this gene is CHRM4.

UniProtKB/Swiss-Prot for HRH1 Gene

  • In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system

Tocris Summary for HRH1 Gene

  • Histamine H1 receptors are Galphaq/11-protein-coupled receptors that mediate allergic responses. These receptors are expressed in a wide variety of tissues including the gastrointestinal tract, central nervous system, airway and vascular smooth muscle cells, endothelial cells, chondrocytes, monocytes, neutrophils, dendritic cells, T and B lymphocytes, adrenal medulla, and the cardiovascular and genitourinary systems. H1 receptor activation induces a wide range of biological responses due to their widespread distribution. In smooth muscle, H1 activation increases tension and the contractile response, and in vascular endothelial cells receptor activation increases cell permeability. In the adrenal medulla, histamine acting at H1 receptors stimulates both adrenalin and noradrenalin release. Furthermore, H1 activation induces prostacyclin and platelet-activating factor synthesis, promotes von Willebrand factor and nitric oxide release, liberates arachidonic acid from phospholipids, and causes vasodilation of capillaries and arterioles. At a physiological level, H1 receptors are involved in a wide array of processes including thermal regulation, memory and learning, and control of the sleep-wake cycle, food intake, and emotional and aggressive behaviors. Histamine acting through the H1 receptor has proinflammatory effects, and is involved in the development of various aspects of the antigen-specific immune response. Activation of these receptors triggers maturation of dendritic cells and modulates the balance of Th1 and Th2 cells. H1 receptors are involved in the pathological process of allergy, including allergic rhinits, atopic dermatitis, anaphylaxis and asthma, and also have a role in autoimmune diseases and malignancy.

Gene Wiki entry for HRH1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HRH1 Gene

Genomics for HRH1 Gene

Regulatory Elements for HRH1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HRH1 Gene

Start:
11,137,093 bp from pter
End:
11,263,557 bp from pter
Size:
126,465 bases
Orientation:
Plus strand

Genomic View for HRH1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HRH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HRH1 Gene

Proteins for HRH1 Gene

  • Protein details for HRH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35367-HRH1_HUMAN
    Recommended name:
    Histamine H1 receptor
    Protein Accession:
    P35367
    Secondary Accessions:
    • A8K047
    • Q6P9E5

    Protein attributes for HRH1 Gene

    Size:
    487 amino acids
    Molecular mass:
    55784 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HRH1 Gene

neXtProt entry for HRH1 Gene

Proteomics data for HRH1 Gene at MOPED

Post-translational modifications for HRH1 Gene

  • Phosphorylation at sites in the second and third cytoplasmic loops independently contribute to agonist-induced receptor downregulation.
  • Glycosylation at Asn5 and Asn18
  • Modification sites at PhosphoSitePlus

Other Protein References for HRH1 Gene

Antibody Products

  • R&D Systems Antibodies for HRH1 (Histamine H1 R)

No data available for DME Specific Peptides for HRH1 Gene

Domains for HRH1 Gene

Gene Families for HRH1 Gene

HGNC:
  • HRH :GPCR / Class A : Histamine receptors
IUPHAR :

Protein Domains for HRH1 Gene

Suggested Antigen Peptide Sequences for HRH1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P35367

UniProtKB/Swiss-Prot:

HRH1_HUMAN :
  • P35367
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HRH1: view

Function for HRH1 Gene

Molecular function for HRH1 Gene

GENATLAS Biochemistry: histamine H1 receptor,ubiquitous,G protein coupled receptor superfamily,activating adenylate cyclase,stimulating contraction on smooth muscle in the gut and bronchs and decreasing blood pressure
UniProtKB/Swiss-Prot Function: In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system

Gene Ontology (GO) - Molecular Function for HRH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 7925364
GO:0004969 histamine receptor activity ISS --
GO:0051381 histamine binding IBA --
genes like me logo Genes that share ontologies with HRH1: view
genes like me logo Genes that share phenotypes with HRH1: view

Animal Models for HRH1 Gene

MGI Knock Outs for HRH1:

miRNA for HRH1 Gene

miRTarBase miRNAs that target HRH1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HRH1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HRH1 Gene

Localization for HRH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HRH1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HRH1 Gene COMPARTMENTS Subcellular localization image for HRH1 gene
Compartment Confidence
plasma membrane 5
nucleus 4
cytosol 3
extracellular 2

Gene Ontology (GO) - Cellular Components for HRH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane ISS --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with HRH1: view

Pathways for HRH1 Gene

genes like me logo Genes that share pathways with HRH1: view

PCR Array Products

Interacting Proteins for HRH1 Gene

Gene Ontology (GO) - Biological Process for HRH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response TAS 10818238
GO:0007186 G-protein coupled receptor signaling pathway ISS --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway TAS 8280179
GO:0007606 sensory perception of chemical stimulus IBA --
GO:0007613 memory IEA --
genes like me logo Genes that share ontologies with HRH1: view

Compounds for HRH1 Gene

(5) Tocris Compounds for HRH1 Gene

Compound Action Cas Number
2-Pyridylethylamine dihydrochloride H1 receptor agonist [3343-39-3]
Astemizole Orally active, potent H1 antagonist. Also KV11.1 (hERG) channel blocker. [68844-77-9]
Fexofenadine hydrochloride H1 receptor antagonist; non-sedating antiallergic agent [153439-40-8]
Ketotifen fumarate H1 antagonist [34580-14-8]
Loratidine Peripheral H1 antagonist; antiallergic agent [79794-75-5]

(11) HMDB Compounds for HRH1 Gene

Compound Synonyms Cas Number PubMed IDs
Brompheniramine
  • Antihistamine compound
86-22-6
Cetirizine
  • Benaday
83881-51-0
Chlorpheniramine
  • Chlor-trimeton
113-92-8
Diphenhydramine
  • Alledryl
147-24-0
Doxylamine
  • Alsadorm
562-10-7

(79) Drugbank Compounds for HRH1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Aceprometazine
  • 10-(2-(Dimethylamino)propyl)phenothiazin-2-yl methyl ketone
13461-01-3 target antagonist
Alcaftadine
  • 6,11-Dihydro-11-(1-Methyl-4-piperidinylidene)-5H-iMidazo[2,1-b][3]benzazepine-3-carboxaldehyde
147084-10-4 target antagonist
Amitriptyline
  • Amitriprolidine
50-48-6 target antagonist
Antazoline
  • Phenazolin
91-75-8 target antagonist
Aripiprazole
  • OPC 31
129722-12-9 target antagonist

(61) IUPHAR Ligand for HRH1 Gene

Ligand Type Action Affinity Pubmed IDs
cyproheptadine Antagonist Antagonist 10.2
doxepin Antagonist Antagonist 10
asenapine Antagonist Antagonist 9.8
A-349821 Antagonist Inverse agonist 9.4
zotepine Antagonist Antagonist 9.2
olanzapine Antagonist Antagonist 9.2
[11C]doxepin Antagonist Antagonist 9
triprolidine Antagonist Antagonist 9
pyrilamine Antagonist Inverse agonist 9
(-)-trans-H2-PAT Antagonist Antagonist 8.8
quetiapine Antagonist Antagonist 8.7
(+)-chlorpheniramine Antagonist Antagonist 8.6
(plusmn)-trans-H2-PAT Antagonist Antagonist 8.6
(R)-cetirizine Antagonist Inverse agonist 8.5
thiothixene Antagonist Antagonist 8.4
histamine Agonist Full agonist 8.3
(plusmn)-cis-H2-PAT Antagonist Antagonist 8.2
cetirizine Antagonist Inverse agonist 8.2
loxapine Antagonist Antagonist 8.2
perphenazine Antagonist Antagonist 8.1
arpromidine Agonist Full agonist 8
diphenhydramine Antagonist Antagonist 7.9
fluspirilene Antagonist Antagonist 7.9
ziprasidone Antagonist Antagonist 7.8
risperidone Antagonist Antagonist 7.8
fluphenazine Antagonist Antagonist 7.7
thioridazine Antagonist Antagonist 7.7
[3H]pyrilamine Antagonist Antagonist 7.5
9-OH-risperidone Antagonist Antagonist 7.5
(+)-trans-H2-PAT Antagonist Antagonist 7.5
aripiprazole Antagonist Antagonist 7.5
trifluoperazine Antagonist Antagonist 7.2
impromidine Agonist Full agonist 7.2
A-317920 Antagonist Antagonist 7
UR-PG136 Agonist Full agonist 7
(+)-cis-H2-PAT Antagonist Antagonist 6.9
sertindole Antagonist Antagonist 6.9
clozapine Antagonist Antagonist 6.7
(S)-cetirizine Antagonist Inverse agonist 6.7
(-)-chlorpheniramine Antagonist Antagonist 6.7
BU-E 47 Antagonist Antagonist 6.6
methylhistaprodifen Agonist Full agonist 6.4
dimethylhistaprodifen Agonist Full agonist 6.4
pimozide Antagonist Antagonist 6.2
haloperidol Antagonist Antagonist 6.1
2-(3-bromophenyl)histamine Agonist Full agonist 6
UR-PG146 Agonist Full agonist 6
2-(3-iodophenyl)histamine Agonist Full agonist 5.8
2-(3-chlorophenyl)histamine Agonist Full agonist 5.7
molindone Antagonist Antagonist 5.7
histaprodifen Agonist Full agonist 5.7
pipamperone Antagonist Antagonist 5.6
2-(2-thiazolyl)ethanamine Agonist Partial agonist 5.34
ABT-239 Antagonist Inverse agonist 5.2
clobenpropit Antagonist Antagonist 5.2
UR-PG55B Agonist Full agonist 5.2
UR-PG131A Agonist Full agonist 4.7
UR-PG153 Agonist Full agonist 4.7
2-pyridylethylamine Agonist Full agonist 3.7
chlorpromazine Channel blocker None
[11C]pyrilamine None None

(121) Novoseek inferred chemical compound relationships for HRH1 Gene

Compound -log(P) Hits PubMed IDs
histamine 92.7 158
mepyramine 91.8 37
ebastine 91.7 16
terfenadine 89.1 30
mizolastine 88.2 6
genes like me logo Genes that share compounds with HRH1: view

Transcripts for HRH1 Gene

Unigene Clusters for HRH1 Gene

Histamine receptor H1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HRH1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HRH1 Gene

No ASD Table

Relevant External Links for HRH1 Gene

GeneLoc Exon Structure for
HRH1
ECgene alternative splicing isoforms for
HRH1

Expression for HRH1 Gene

mRNA expression in normal human tissues for HRH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HRH1 Gene

This gene is overexpressed in Artery - Aorta (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HRH1 Gene

SOURCE GeneReport for Unigene cluster for HRH1 Gene Hs.1570

genes like me logo Genes that share expressions with HRH1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HRH1 Gene

Orthologs for HRH1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HRH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HRH1 35
  • 99.18 (n)
  • 98.97 (a)
HRH1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HRH1 35
  • 84.67 (n)
  • 82.55 (a)
HRH1 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HRH1 35
  • 86.65 (n)
  • 86.24 (a)
HRH1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hrh1 35
  • 80.73 (n)
  • 78.4 (a)
Hrh1 16
Hrh1 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 23 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia HRH1 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hrh1 35
  • 80.3 (n)
  • 79.34 (a)
chicken
(Gallus gallus)
Aves HRH1 35
  • 54.88 (n)
  • 51.93 (a)
HRH1 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HRH1 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495566 35
  • 64.62 (n)
  • 62.87 (a)
zebrafish
(Danio rerio)
Actinopterygii hrh1 35
  • 52.84 (n)
  • 46.41 (a)
hrh1 36
  • 37 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7918 36
  • 13 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gar-1 36
  • 14 (a)
ManyToMany
gar-2 36
  • 15 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
Species with no ortholog for HRH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HRH1 Gene

ENSEMBL:
Gene Tree for HRH1 (if available)
TreeFam:
Gene Tree for HRH1 (if available)

Paralogs for HRH1 Gene

Paralogs for HRH1 Gene

Selected SIMAP similar genes for HRH1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HRH1: view

Variants for HRH1 Gene

Sequence variations from dbSNP and Humsavar for HRH1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs164100 -- 11,230,962(+) agttc(C/T)gtcac intron-variant
rs164101 -- 11,239,396(+) tcttt(A/G)tgtat intron-variant
rs168333 -- 11,185,774(+) GTGTC(A/G)TGTTG intron-variant
rs184700 -- 11,251,375(-) tccac(A/G)ccttt upstream-variant-2KB, intron-variant
rs238615 -- 11,192,443(+) TCCAC(A/G)GTGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HRH1 Gene

Variant ID Type Subtype PubMed ID
dgv809e201 CNV Deletion 23290073
nsv436362 CNV Deletion 17901297
nsv436869 CNV Insertion 17901297
esv4117 CNV Complex 18987735
nsv876535 CNV Gain 21882294
esv2609663 CNV Insertion 19546169
esv273392 CNV Insertion 20981092
esv268134 CNV Insertion 20981092
esv2724908 CNV Deletion 23290073
esv2151338 CNV Deletion 18987734
esv2724909 CNV Deletion 23290073

Relevant External Links for HRH1 Gene

HapMap Linkage Disequilibrium report
HRH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HRH1 Gene

Disorders for HRH1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (9) Diseases for HRH1 Gene including...

Search for HRH1 Gene in MalaCards »

(46) Novoseek inferred disease relationships for HRH1 Gene

Disease -log(P) Hits PubMed IDs
allergic rhinitis 75.6 13
urticaria chronic 75.2 2
rhinitis allergic perennial 70.6 2
conjunctivitis allergic 69 3
chronic rhinitis 67.1 1

Relevant External Links for HRH1

Genetic Association Database (GAD)
HRH1
Human Genome Epidemiology (HuGE) Navigator
HRH1
genes like me logo Genes that share disorders with HRH1: view

No data available for UniProtKB/Swiss-Prot for HRH1 Gene

Publications for HRH1 Gene

  1. Genomic cloning, heterologous expression and pharmacological characterization of a human histamine H1 receptor. (PMID: 8280179) de Backer M.D. … Luyten W.H.M.L. (Biochem. Biophys. Res. Commun. 1993) 3 4 23
  2. Stable expression of human H1-histamine-receptor cDNA in Chinese hamster ovary cells. Pharmacological characterisation of the protein, tissue distribution of messenger RNA and chromosomal localisation of the gene. (PMID: 7925364) Moguilevsky N. … Bollen A. (Eur. J. Biochem. 1994) 3 4 23
  3. Polymorphisms of high-affinity IgE receptor and histamine-related genes in patients with ASA-induced urticaria/angioedema. (PMID: 15953854) Choi J.H. … Park H.S. (J. Korean Med. Sci. 2005) 3 23 48
  4. Two threonine residues and two serine residues in the second and third intracellular loops are both involved in histamine H1 receptor downregulation. (PMID: 15328002) Horio S. … Fukui H. (FEBS Lett. 2004) 3 4 23
  5. Molecular cloning of the human histamine H1 receptor gene. (PMID: 8003029) Fukui K. … Ito S. (Biochem. Biophys. Res. Commun. 1994) 2 3 4

Products for HRH1 Gene

Sources for HRH1 Gene

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