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HRH1 Gene

protein-coding   GIFtS: 66
GCID: GC03P011113

Histamine Receptor H1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Histamine Receptor H11 2     hisH12
H1R2 3     Histamine H(1) Receptor2
HH1R2 3     Histamine H1 Receptor2
H1-R2     Histamine Receptor, Subclass H12

External Ids:    HGNC: 51821   Entrez Gene: 32692   Ensembl: ENSG000001966397   OMIM: 6001675   UniProtKB: P353673   

Export aliases for HRH1 gene to outside databases

Previous GC identifers: GC03P011223 GC03P011270 GC03P011271 GC03P011272


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HRH1 Gene:
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons.
Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene was thought to be intronless
until recently. The protein encoded by this gene is an integral membrane protein and belongs to the G
protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary
permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and
neurotransmission in the central nervous system. Multiple alternatively spliced variants, encoding the same
protein, have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for HRH1 Gene:
HRH1 (histamine receptor H1) is a protein-coding gene. Diseases associated with HRH1 include cholinergic urticaria, and chronic rhinitis. GO annotations related to this gene include G-protein coupled receptor activity and histamine receptor activity. An important paralog of this gene is HTR2A.

UniProtKB/Swiss-Prot: HRH1_HUMAN, P35367
Function: In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth
muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release
from adrenal medulla, as well as mediating neurotransmission in the central nervous system

summary for HRH1 Gene:
Histamine H1 receptors are Galphaq/11-protein-coupled receptors that mediate allergic responses. These
receptors are expressed in a wide variety of tissues including the gastrointestinal tract, central nervous
system, airway and vascular smooth muscle cells, endothelial cells, chondrocytes, monocytes, neutrophils,
dendritic cells, T and B lymphocytes, adrenal medulla, and the cardiovascular and genitourinary systems. H1
receptor activation induces a wide range of biological responses due to their widespread distribution. In
smooth muscle, H1 activation increases tension and the contractile response, and in vascular endothelial
cells receptor activation increases cell permeability. In the adrenal medulla, histamine acting at H1
receptors stimulates both adrenalin and noradrenalin release. Furthermore, H1 activation induces
prostacyclin and platelet-activating factor synthesis, promotes von Willebrand factor and nitric oxide
release, liberates arachidonic acid from phospholipids, and causes vasodilation of capillaries and
arterioles. At a physiological level, H1 receptors are involved in a wide array of processes including
thermal regulation, memory and learning, and control of the sleep-wake cycle, food intake, and emotional and
aggressive behaviors. Histamine acting through the H1 receptor has proinflammatory effects, and is involved
in the development of various aspects of the antigen-specific immune response. Activation of these receptors
triggers maturation of dendritic cells and modulates the balance of Th1 and Th2 cells. H1 receptors are
involved in the pathological process of allergy, including allergic rhinits, atopic dermatitis, anaphylaxis
and asthma, and also have a role in autoimmune diseases and malignancy.

Gene Wiki entry for HRH1 (Histamine H1 receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the HRH1 gene promoter:
         GR   GCNF   STAT5A   MIF-1   S8   HSF2   GCNF-1   c-Myb   GR-alpha   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHRH1 promoter sequence
   Search Chromatin IP Primers for HRH1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HRH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25   Ensembl cytogenetic band:  3p25.3   HGNC cytogenetic band: 3p25

HRH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HRH1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P011113:  view genomic region     (about GC identifiers)

Start:
11,178,779 bp from pter      End:
11,305,243 bp from pter
Size:
126,465 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HRH1_HUMAN, P35367 (See protein sequence)
Recommended Name: Histamine H1 receptor  
Size: 487 amino acids; 55784 Da
1 PDB 3D structure from and Proteopedia for HRH1:
3RZE (3D)    
Secondary accessions: A8K047 Q6P9E5

Explore the universe of human proteins at neXtProt for HRH1: NX_P35367

Explore proteomics data for HRH1 at MOPED

Post-translational modifications: 

  • Phosphorylation at sites in the second and third cytoplasmic loops independently contribute to agonist-induced
    receptor downregulation1
  • Glycosylation2 at Asn5, Asn18
  • Modification sites at PhosphoSitePlus

  • See HRH1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_000852.1  NP_001091681.1  NP_001091682.1  NP_001091683.1  

    ENSEMBL proteins: 
     ENSP00000406705   ENSP00000397028   ENSP00000392383   ENSP00000380247  
    Reactome Protein details: P35367

    HRH1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant HRH1 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for HRH1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for HRH1
    GenScript Custom Purified and Recombinant Proteins Services for HRH1
    Novus Biologicals HRH1 Proteins
    Novus Biologicals HRH1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HRH1

    HRH1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HRH1
    R&D Systems Antibodies for HRH1 (Histamine H1 R)
    OriGene Antibodies for HRH1
    OriGene Custom Antibody Services for HRH1
    Novus Biologicals HRH1 Antibodies
    Abcam antibodies for HRH1
    Cloud-Clone Corp. Antibodies for HRH1
    ThermoFisher Antibodies for HRH1
    LSBio Antibodies in human, mouse, rat for HRH1

    HRH1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HRH1
    Browse R&D Systems for biochemical assays
    GenScript HRH1-overexpressing Cell Line for Assay
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HRH1
    Cloud-Clone Corp. CLIAs for HRH1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HRH: GPCR / Class A : Histamine receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: H1 receptor
    Histamine receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn
     IPR000921 Histamine_H1_rcpt

    Graphical View of Domain Structure for InterPro Entry P35367

    ProtoNet protein and cluster: P35367

    1 Blocks protein domain: IPB000921 Histamine H1 receptor signature

    UniProtKB/Swiss-Prot: HRH1_HUMAN, P35367
    Similarity: Belongs to the G-protein coupled receptor 1 family


    HRH1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HRH1_HUMAN, P35367
    Function: In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth
    muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release
    from adrenal medulla, as well as mediating neurotransmission in the central nervous system

         Genatlas biochemistry entry for HRH1:
    histamine H1 receptor,ubiquitous,G protein coupled receptor superfamily,activating adenylate cyclase,stimulating
    contraction on smooth muscle in the gut and bronchs and decreasing blood pressure

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS7925364
    GO:0004969histamine receptor activity ISS--
         
    HRH1 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Hrh1):
     adipose tissue  behavior/neurological  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system 

    HRH1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Hrh1tm1Wtn for HRH1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HRH1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HRH1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HRH1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HRH1

    miRNA
    Products:
        
    miRTarBase miRNAs that target HRH1:
    hsa-mir-124-3p (MIRT022836), hsa-mir-192-5p (MIRT004851)

    Block miRNA regulation of human, mouse, rat HRH1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HRH1 (see all 31):
    hsa-miR-2052 hsa-miR-3910 hsa-miR-3128 hsa-miR-875-3p hsa-miR-631 hsa-miR-520d-5p hsa-miR-4251 hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidHRH1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HRH1
    Predesigned siRNA for gene silencing in human, mouse, rat HRH1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HRH1

    Clone
    Products:
         
    OriGene clones in human, mouse for HRH1 (see all 23)
    OriGene ORF clones in mouse, rat for HRH1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): HRH1 (NM_001098212)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HRH1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HRH1

    Cell Line
    Products:
         
    GenScript HRH1-overexpressing Cell Line for Assay
    Browse ESI BIO Cell Lines and PureStem Progenitors for HRH1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRH1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HRH1_HUMAN, P35367: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus4
    cytosol3
    extracellular2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane ISS--
    GO:0016021integral component of membrane ----

    HRH1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HRH1 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Monoamine GPCRs
    Monoamine GPCRs0.79
    Histamine receptors0.00
    Amine ligand-binding receptors0.79
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    5Transcription CREB pathway
    Development Ligand independent activation of ESR1 and ESR20.34
    Transcription CREB pathway0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for HRH1
        Development Ligand-independent activation of ESR1 and ESR2
    Transcription CREB pathway

    2 BioSystems Pathways for HRH1
        GPCRs, Class A Rhodopsin-like
    Monoamine GPCRs

    2 Reactome Pathways for HRH1
        G alpha (q) signalling events
    Histamine receptors


    3 Kegg Pathways  (Kegg details for HRH1):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Inflammatory mediator regulation of TRP channels


    HRH1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HRH1: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Obesity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HRH1

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response TAS10818238
    GO:0007186G-protein coupled receptor signaling pathway TAS7925364
    GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway TAS8280179
    GO:0007613memory IEA--
    GO:0008542visual learning IEA--

    HRH1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for HRH1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Clemastine fumarateH1 antagonist[14976-57-9]
    Histamine dihydrochlorideEndogenous histamine receptor agonist[56-92-8]
    2-Pyridylethylamine dihydrochlorideH1 receptor agonist[3343-39-3]
    Astemizole Orally active, potent H1 antagonist. Also KV11.1 (hERG) channel blocker. [68844-77-9]
    Mepyramine maleateSelective H1 inverse agonist[59-33-6]

    Selected HMDB Compounds for HRH1 (see all 11)    About this table
    CompoundSynonyms CAS #PubMed Ids
    BrompheniramineAntihistamine compound (see all 18)86-22-6--
    CetirizineBenaday (see all 9)83881-51-0--
    ChlorpheniramineChlor-trimeton (see all 8)113-92-8--
    DiphenhydramineAlledryl (see all 14)147-24-0--
    DoxylamineAlsadorm (see all 8)562-10-7--
    FexofenadineAllegra (see all 6)83799-24-0--
    Histamine1H-Imidazole-4-ethanamine (see all 27)51-45-6--
    LoratadineAlavert (see all 20)79794-75-5--
    OlanzapineLanzac (see all 5)132539-06-1--
    QuetiapineQuetiapine fumarate (see all 2)111974-69-7--

    Selected DrugBank Compounds for HRH1 (see all 79)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ClemastineClemastina [INN-Spanish] (see all 3)15686-51-8targetantagonist1678430 8930778 2890562 6387510 6701456 11752352 4074605 6449094 7513381 1266718
    Doxepin-- 1668-19-5targetantagonist2141000 7238574 15255990 7855217 19179941 15286093 11752352 6086881 17685877 3011460
    FexofenadineCarboxyterfenadine (see all 6)83799-24-0targetantagonist12712828 9506246 19545214 15286093 11752352 10597865 18336052 10864400 18797058 15352500
    LoratadineLoratadina [Spanish] (see all 2)79794-75-5targetantagonist1977506 1303773 7581058 11752352 10597865 1303772 15942272 11291777 8174605 9444440
    Triprolidine-- 486-12-4targetantagonist2568212 10493107 8907591 11752352 2866055 7853212 7214150 3011460 7913608 10582735
    Olopatadine-- 113806-05-6targetantagonist15646365 12046981 20482305 8951675 11752352 20406593 15942272 11496828 20402382
    Astemizole-- 68844-77-9targetantagonist6204835 6146346 2892659 11752352 3147222 10597865 8001268 10597866
    DesloratadineDescarboethoxyloratadine (see all 3)100643-71-8targetantagonist7581058 15564772 12642846 11752352 18336052 17902729 18797058 8174605
    PheniramineFeniramina [inn-spanish] (see all 5)86-21-5targetantagonist2567596 20027159 7714410 14506317 11752352 17016423 8835636 11526976
    AzelastineAzelastina [INN-Spanish] (see all 2)58581-89-8targetantagonist9585822 10478514 19209282 11752352 2540229 17723160 8829888

    Selected IUPHAR Ligands for HRH1 (H1 receptor) (see all 61)    About this table
    LigandTypeActionAffinityPubmed IDs
    cyproheptadine
    AntagonistAntagonist10.27925364
    doxepin
    AntagonistAntagonist9.5 - 1012065734
    asenapine
    AntagonistAntagonist9.88935801
    clozapine
    AntagonistAntagonist8.8 - 9.612065734 8935801 12629531
    zotepine
    AntagonistAntagonist9.28935801
    olanzapine
    AntagonistAntagonist8.7 - 9.28935801 12629531
    [3H]pyrilamine
    AntagonistInverse agonist8.4 - 9.18935801 7925364 9794809 12626648
    [11C]doxepin
    AntagonistAntagonist915093820
    triprolidine
    AntagonistAntagonist8.5 - 912065734 7925364
    pyrilamine
    AntagonistInverse agonist8.7 - 912065734 15206929

    Selected Novoseek inferred chemical compound relationships for HRH1 gene (see all 121)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    histamine 92.7 363 1972050 (5), 8088416 (4), 11603849 (4), 8198587 (3) (see all 99)
    mepyramine 91.8 39 7853212 (3), 8114011 (1), 8806799 (1), 7693285 (1) (see all 35)
    ebastine 91.7 19 8808167 (2), 9196279 (2), 8828024 (1), 11419742 (1) (see all 14)
    terfenadine 89.1 32 1972050 (4), 1976343 (2), 9196279 (2), 8886862 (1) (see all 25)
    mizolastine 88.2 6 10209699 (2), 16402861 (1), 11510627 (1), 11683039 (1) (see all 5)
    chlorpheniramine 87.9 17 12950664 (1), 7541689 (1), 7853212 (1), 7648771 (1) (see all 15)
    triprolidine 87.5 4 7853212 (1), 16569656 (1), 7913608 (1), 7650688 (1)
    anti-histamine 86.6 18 8750798 (2), 7625332 (1), 8564232 (1), 17558437 (1) (see all 13)
    cetirizine 86.4 16 7510611 (2), 8886862 (1), 10876807 (1), 1676245 (1) (see all 15)
    epinastine 86.2 14 8750798 (2), 10807498 (2), 18396776 (1), 7650688 (1) (see all 8)



    HRH1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HRH1 gene (4 alternative transcripts): 
    NM_000861.3  NM_001098211.1  NM_001098212.1  NM_001098213.1  

    Unigene Cluster for HRH1:

    Histamine receptor H1
    Hs.1570  [show with all ESTs]
    Unigene Representative Sequence: NM_001098213
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000438284 ENST00000431010(uc010hdr.3 uc010hds.3 uc010hdt.3)
    ENST00000413416 ENST00000397056(uc003bwb.4)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HRH1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HRH1 (see all 31):
    hsa-miR-2052 hsa-miR-3910 hsa-miR-3128 hsa-miR-875-3p hsa-miR-631 hsa-miR-520d-5p hsa-miR-4251 hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidHRH1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for HRH1
    Predesigned siRNA for gene silencing in human, mouse, rat HRH1
    Clone
    Products:
         
    OriGene clones in human, mouse for HRH1 (see all 23)
    OriGene ORF clones in mouse, rat for HRH1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): HRH1 (NM_001098212)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HRH1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HRH1
    Primer
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    OriGene qPCR primer pairs and template standards for HRH1
    OriGene qSTAR qPCR primer pairs in human, mouse for HRH1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HRH1
      QuantiTect SYBR Green Assays in human, mouse, rat HRH1
      QuantiFast Probe-based Assays in human, mouse, rat HRH1

    Additional mRNA sequence: 

    AF026261.1 AK289412.1 AK292157.1 AK312879.1 AY136743.1 BC060802.1 D28481.1 Z34897.1 

    5 DOTS entries:

    DT.108434  DT.120856026  DT.120856016  DT.405455  DT.75141601 

    Selected AceView cDNA sequences (see all 51):

    BU187066 AI203543 BQ014690 BF513144 AW452821 AF026261 AA373094 AY136743 
    BX436453 BQ019585 BQ017843 D28481 Z34897 AA582697 CB114530 CB120001 
    AA613545 BG287152 AI926322 AI954670 CB115769 AI889049 NM_000861 AW044630 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HRH1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCTGTCAAA
    HRH1 Expression
    About this image


    HRH1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     NULL (Uncategorized)
             CD31, CD144 positive cells
     
     Endothelium (Cardiovascular System)
             Human umbilical vein endothelial cells (HUVEC)
     
     Blood (Hematopoietic System)
             pre Conventional Dendritic Cells Peripheral Blood
     
     Eye (Sensory Organs)
             Retina
    HRH1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HRH1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1570
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HRH1: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Obesity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for HRH1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hrh11 , 5 histamine receptor H11, 5 80.73(n)1
    78.4(a)1
      6 (53.05 cM)5
    154651  NM_001252642.11  NP_001239571.11 
     1143979365 
    chicken
    (Gallus gallus)
    Aves HRH11 histamine receptor H1 54.88(n)
    51.93(a)
      100858928  XM_004944510.1  XP_004944567.1 
    lizard
    (Anolis carolinensis)
    Reptilia HRH16
    histamine receptor H1
    50(a)
    1 ↔ 1
    2(157913858-157915342)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004955661 histamine H1 receptor-like 64.62(n)
    62.87(a)
      100495566  XM_002944349.2  XP_002944395.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hrh11 histamine receptor H1 52.84(n)
    46.41(a)
      735302  NM_001042731.1  NP_001036196.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG79186
    --
    13(a)
    1 → many
    3R(3885006-3912767)
    worm
    (Caenorhabditis elegans)
    Secernentea gar-26
    gar-16
    Protein GAR-2, isoform d
    Protein GAR-1, isoform c (gar-1) mRNA, complete cd...
    15(a)
    14(a)
    many ↔ many
    many ↔ many
    III(6309378-6320871) WBGene00001518
    X(6479638-6484810) WBGene00001517


    ENSEMBL Gene Tree for HRH1 (if available)
    TreeFam Gene Tree for HRH1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HRH1 gene
    HTR2A2  DRD42  DRD22  CHRM12  CHRM22  HRH32  HTR2B2  HRH42  
    HTR2C2  CHRM52  DRD32  CHRM42  CHRM32  
    2 SIMAP similar genes for HRH1 using alignment to 2 protein entries:     HRH1_HUMAN (see all proteins):
    CHRM2    CHRM4

    HRH1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HRH1 (see all 2857)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357614
    A colorectal cancer sample4--see VAR_0357612 D E mis40--------
    rs607289321,2
    C,F--11176812(+) TGGTGG/TCTTAG 1 -- us2k12Minor allele frequency- T:0.10WA 120
    rs1477969281,2
    --11176863(+) AAGAAC/TCTGGG 1 -- us2k10--------
    rs67782701,2
    C,F,A,H--11176867(+) ACCTGA/GGAACA 1 -- us2k127Minor allele frequency- N:0.00NS EA NA WA 2970
    rs1466750651,2
    --11177002(+) TTTTGA/TTTTGT 1 -- us2k10--------
    rs586186531,2
    C--11177040(+) ATAGAG/ATTTCG 1 -- us2k16Minor allele frequency- A:0.29WA CSA NA EA 364
    rs1146592791,2
    C,F--11177045(+) GTTTCG/ACTCTT 1 -- us2k12Minor allele frequency- A:0.02WA NA 238
    rs1483510631,2
    C--11177077(+) TGGTGC/TGATCT 1 -- us2k10--------
    rs1880457151,2
    --11177091(+) CTCACC/TGCAGC 1 -- us2k10--------
    rs579254791,2
    C--11177095(+) CCGCAG/ACCTCC 1 -- us2k15Minor allele frequency- A:0.21WA CSA NA EA 362

    HapMap Linkage Disequilibrium report for HRH1 (11178779 - 11305243 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HRH1 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv436362CNV Deletion17901297
    esv2724909CNV Deletion23290073
    dgv809e201CNV Deletion23290073
    esv2151338CNV Deletion18987734
    esv2724908CNV Deletion23290073
    esv268134CNV Insertion20981092
    nsv436869CNV Insertion17901297
    esv273392CNV Insertion20981092
    esv2609663CNV Insertion19546169
    nsv876535CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HRH1
    DNA2.0 Custom Variant and Variant Library Synthesis for HRH1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600167    OMIM disorders: --

    Selected diseases for HRH1 (see all 55):    
    About MalaCards
    cholinergic urticaria    chronic rhinitis    dermatitis    arthus reaction
    atopic dermatitis    urticaria    allergic rhinitis    allergic conjunctivitis
    rhinitis    interstitial nephritis    conjunctivitis    asthma
    angioedema    food allergy    chorioamnionitis    malaria
    bronchitis    cystitis    otitis media    endotheliitis

    6 diseases from the University of Copenhagen DISEASES database for HRH1:
    Allergic rhinitis     Urticaria     Asthma     Hypersensitivity reaction type I disease
    Conjunctivitis     Atopic dermatitis

    HRH1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for HRH1 gene (see all 46)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    allergic rhinitis 75.6 13 9664202 (1), 18498711 (1), 19558341 (1), 8732234 (1) (see all 13)
    urticaria chronic 75.2 2 8828024 (1), 1685361 (1)
    rhinitis allergic perennial 70.6 2 8828024 (1), 12269652 (1)
    conjunctivitis allergic 69 4 12431041 (1), 19558341 (1), 17075271 (1)
    chronic rhinitis 67.1 1 10879992 (1)
    rhinitis allergic seasonal 65.2 3 15160440 (1), 16882083 (1), 9585822 (1)
    prurigo 64.6 1 19558341 (1)
    urticaria 56.8 6 17902729 (1), 20128233 (1), 14727529 (1), 2083605 (1) (see all 6)
    rhinitis 56.2 2 9923056 (1), 1972050 (1)
    asthma 51.5 9 1976343 (1), 11243501 (1), 15661077 (1), 16484687 (1) (see all 9)

    Genetic Association Database (GAD): HRH1
    Human Genome Epidemiology (HuGE) Navigator: HRH1 (14 documents)

    Export disorders for HRH1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HRH1 gene, integrated from 10 sources (see all 642):
    (articles sorted by number of sources associating them with HRH1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the human histamine H1 receptor gene. (PubMed id 8003029)1, 2, 3 Fukui K.... Ito S. (Biochem. Biophys. Res. Commun. 1994)
    2. Genomic cloning, heterologous expression and pharmacological characterization of a human histamine H1 receptor. (PubMed id 8280179)1, 2, 9 de Backer M.D.... Luyten W.H.M.L. (Biochem. Biophys. Res. Commun. 1993)
    3. Two threonine residues and two serine residues in the second and third intracellular loops are both involved in histamine H1 receptor downregulation. (PubMed id 15328002)1, 2, 9 Horio S.... Fukui H. (FEBS Lett. 2004)
    4. Stable expression of human H1-histamine-receptor cDNA in Chinese hamster ovary cells. Pharmacological characterisation of the protein, tissue distribution of messenger RNA and chromosomal localisation of the gene. (PubMed id 7925364)1, 2, 9 Moguilevsky N.... Bollen A. (Eur. J. Biochem. 1994)
    5. Polymorphisms of high-affinity IgE receptor and histamine-related genes in patients with ASA-induced urticaria/angioedema. (PubMed id 15953854)1, 4, 9 Choi J.H....Park H.S. (J. Korean Med. Sci. 2005)
    6. Structure of the human histamine H1 receptor complex with doxepin. (PubMed id 21697825)1, 2 Shimamura T.... Iwata S. (Nature 2011)
    7. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (Pharmacogenomics 2010)
    8. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (Eur. J. Hum. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3269 HGNC: 5182 AceView: HRH1 Ensembl:ENSG00000196639 euGenes: HUgn3269
    ECgene: HRH1 Kegg: 3269 H-InvDB: HRH1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HRH1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HRH1 gene:
    Search GeneIP for patents involving HRH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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