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Aliases for HRG Gene

Aliases for HRG Gene

  • Histidine Rich Glycoprotein 2 3 5
  • Histidine-Proline-Rich Glycoprotein 3 4
  • Histidine-Rich Glycoprotein 2 3
  • HPRG 3 4
  • Histidine-Proline Rich Glycoprotein 2
  • Thrombophilia Due To Elevated HRG 2
  • THPH11 3
  • HRGP 3

External Ids for HRG Gene

Previous GeneCards Identifiers for HRG Gene

  • GC03P183155
  • GC03P187640
  • GC03P187785
  • GC03P187704
  • GC03P187866
  • GC03P186378
  • GC03P183793

Summaries for HRG Gene

Entrez Gene Summary for HRG Gene

  • This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. The encoded protein also has a peptide that displays antimicrobial activity against C. albicans, E. coli, S. aureus, P. aeruginosa, and E. faecalis. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels. [provided by RefSeq, Nov 2014]

GeneCards Summary for HRG Gene

HRG (Histidine Rich Glycoprotein) is a Protein Coding gene. Diseases associated with HRG include Thrombophilia Due To Hrg Deficiency and Thrombophilia. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Dissolution of Fibrin Clot. GO annotations related to this gene include receptor binding and heme binding.

UniProtKB/Swiss-Prot for HRG Gene

  • Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Binds heparin and heparin/glycosaminoglycans in a zinc-dependent manner. Binds heparan sulfate on the surface of liver, lung, kidney and heart endothelial cells. Binds to N-sulfated polysaccharide chains on the surface of liver endothelial cells. Inhibits rosette formation. Acts as an adapter protein and is implicated in regulating many processes such as immune complex and pathogen clearance, cell chemotaxis, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in a heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the formation of insoluble immune complexes. Tethers plasminogen to the cell surface. Binds T-cells and alters the cell morphology. Modulates angiogenesis by blocking the CD6-mediated antiangiongenic effect of thrombospondins, THBS1 and THBS2. Acts as a regulator of the vascular endothelial growth factor (VEGF) signaling pathway; inhibits endothelial cell motility by reducing VEGF-induced complex formation between PXN/paxillin and ILK/integrin-linked protein kinase and by promoting inhibition of VEGF-induced tyrosine phosphorylation of focal adhesion kinases and alpha-actinins in endothelial cells. Also plays a role in the regulation of tumor angiogenesis and tumor immune surveillance. Normalizes tumor vessels and promotes antitumor immunity by polarizing tumor-associated macrophages, leading to decreased tumor growth and metastasis.

Gene Wiki entry for HRG Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HRG Gene

Genomics for HRG Gene

Regulatory Elements for HRG Gene

Enhancers for HRG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G187015 1.4 Ensembl ENCODE dbSUPER 9.2 +356.6 356580 2.8 HDGF PKNOX1 TBL1XR1 THRB RARA GATA2 FOS RELB ETV6 IKZF2 ADIPOQ ADIPOQ-AS1 ST6GAL1 HRG GC03P186997 GC03P186996 PIR46786
GH03G186588 1.2 Ensembl ENCODE 10 -70.3 -70303 3.2 PKNOX1 FOXA2 ARNT BRCA1 RAD21 CHAMP1 RARA GTF3C2 SLC30A9 ZNF366 ENSG00000200418 TBCCD1 AHSG EIF4A2 SNORD2 SNORA63 SNORA81 SNORA4 ENSG00000231724 RFC4
GH03G187011 1.3 Ensembl ENCODE dbSUPER 9.2 +352.6 352567 2.8 HDGF FOXA2 CHD4 MAX RAD21 YY1 POLR2A EED ZNF207 IKZF2 ADIPOQ ST6GAL1 HRG GC03P186996 GC03P186997 PIR46786
GH03G186752 1.2 Ensembl ENCODE 9.7 +93.9 93922 3.9 FOXA2 ARID4B BRCA1 YY1 TCF12 ZNF121 FOS JUNB REST KAT8 EIF4A2 KNG1 ENSG00000200418 SNORA63 SNORA81 RFC4 FETUB ENSG00000231724 AHSG HRG
GH03G186596 1 Ensembl ENCODE 10.2 -63.2 -63216 0.4 HDAC1 CTCF ATF1 JUN CEBPG ZBTB40 IRF9 TRIM24 ZNF584 ZNF263 FETUB KNG1 HRG RFC4 ENSG00000231724 ENSG00000283390 AHSG
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HRG on UCSC Golden Path with GeneCards custom track

Genomic Location for HRG Gene

Chromosome:
3
Start:
186,660,216 bp from pter
End:
186,678,240 bp from pter
Size:
18,025 bases
Orientation:
Plus strand

Genomic View for HRG Gene

Genes around HRG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HRG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HRG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HRG Gene

Proteins for HRG Gene

  • Protein details for HRG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04196-HRG_HUMAN
    Recommended name:
    Histidine-rich glycoprotein
    Protein Accession:
    P04196
    Secondary Accessions:
    • B9EK35
    • D3DNU7

    Protein attributes for HRG Gene

    Size:
    525 amino acids
    Molecular mass:
    59578 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts (via the HRR domain) with TPM1; the interaction appears to contribute to the antiangiogenic properties of the HRR domain. Interacts with THBS2; the interaction blocks the antiangiogenic effect of THBS2 with CD36 (By similarity). Interacts with THBS1 (via the TSP type I repeats); the interaction blocks the antiangiogenic effect of THBS1 with CD3. Interacts with PLG (via its Kringle domains); the interaction tethers PLG to the cell surface and enhances its activation. Interacts with HPSE; the interaction is enhanced at acidic pH, partially inhibits binding of HPSE to cell surface receptors and modulates its enzymatic activity. Interacts (via the HRR domain) with TMP1; the interaction partially mediates the antiangiogenic properties of HRG. Interacts with kappa and lambda light chains of IgG molecules. Interacts with ATP5A1; the interaction occurs on the surface of T-cells and alters their cell morphology in concert with CONA. Binds IgG molecules containing kappa and lambda light chains and inhibits the formation of insoluble immunoglobulin complexes. Interacts with F12; the interaction, which is enhanced in the presence of zinc ions and inhibited by heparin-binding to HRG, inhibits factor XII autoactivation and contact-initiated coagulation.

neXtProt entry for HRG Gene

Post-translational modifications for HRG Gene

  • N-glycosylated.
  • Proteolytic cleavage produces several HRG fragments which are mostly disulfide-linked and, therefore, not released. Cleavage by plasmin is inhibited in the presence of heparin, zinc ions or in an acidic environment. Cleavage reduces binding of HRG to heparan sulfate, but enhances the ability of HRG to bind and tether plasminogen to the cell surface. On platelet activation, releases a 33 kDa antiangiogenic peptide which encompasses the HRR. Also cleaved in the C-terminal by plasmin.
  • Glycosylation at isoforms=63, posLast=125125, posLast=344344, and posLast=345345
  • Modification sites at PhosphoSitePlus

Other Protein References for HRG Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for HRG
  • Santa Cruz Biotechnology (SCBT) Antibodies for HRG

No data available for DME Specific Peptides for HRG Gene

Domains & Families for HRG Gene

Gene Families for HRG Gene

Protein Domains for HRG Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for HRG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P04196

UniProtKB/Swiss-Prot:

HRG_HUMAN :
  • The His/Pro-rich (HRR) region contains approximately 12 tandem internal repeats of the 5-residue G[H/P][H/P]PH consensus sequence. HRR binds heparan sulfate and possesses antiangiogenic, antibacterial and antifungal properties through binding Candida cells, and preferentially lysing the ergosterol-containing liposomes at low pH. The tandem repeats also bind divalent metal ions and heme.
Domain:
  • The His/Pro-rich (HRR) region contains approximately 12 tandem internal repeats of the 5-residue G[H/P][H/P]PH consensus sequence. HRR binds heparan sulfate and possesses antiangiogenic, antibacterial and antifungal properties through binding Candida cells, and preferentially lysing the ergosterol-containing liposomes at low pH. The tandem repeats also bind divalent metal ions and heme.
  • The cystatin domains can also bind heparan sulfate. Binding is enhanced in the presence of zinc ions.
genes like me logo Genes that share domains with HRG: view

Function for HRG Gene

Molecular function for HRG Gene

GENATLAS Biochemistry:
histidine-rich glycoprotein (plasma),binding plasminogen and heparin,cystatin (cysteine proteinase inhibitor) superfamily,interacting with plasma proteins involved in blood coagulation and fibronolysis
UniProtKB/Swiss-Prot Function:
Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Binds heparin and heparin/glycosaminoglycans in a zinc-dependent manner. Binds heparan sulfate on the surface of liver, lung, kidney and heart endothelial cells. Binds to N-sulfated polysaccharide chains on the surface of liver endothelial cells. Inhibits rosette formation. Acts as an adapter protein and is implicated in regulating many processes such as immune complex and pathogen clearance, cell chemotaxis, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in a heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the formation of insoluble immune complexes. Tethers plasminogen to the cell surface. Binds T-cells and alters the cell morphology. Modulates angiogenesis by blocking the CD6-mediated antiangiongenic effect of thrombospondins, THBS1 and THBS2. Acts as a regulator of the vascular endothelial growth factor (VEGF) signaling pathway; inhibits endothelial cell motility by reducing VEGF-induced complex formation between PXN/paxillin and ILK/integrin-linked protein kinase and by promoting inhibition of VEGF-induced tyrosine phosphorylation of focal adhesion kinases and alpha-actinins in endothelial cells. Also plays a role in the regulation of tumor angiogenesis and tumor immune surveillance. Normalizes tumor vessels and promotes antitumor immunity by polarizing tumor-associated macrophages, leading to decreased tumor growth and metastasis.

Gene Ontology (GO) - Molecular Function for HRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IBA --
GO:0004869 cysteine-type endopeptidase inhibitor activity IEA --
GO:0005102 receptor binding IDA 16436387
GO:0005515 protein binding IPI 11134179
GO:0008201 heparin binding IEA,IDA 16436387
genes like me logo Genes that share ontologies with HRG: view
genes like me logo Genes that share phenotypes with HRG: view

Human Phenotype Ontology for HRG Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HRG Gene

Localization for HRG Gene

Subcellular locations from UniProtKB/Swiss-Prot for HRG Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HRG gene
Compartment Confidence
plasma membrane 5
extracellular 5
lysosome 3
endosome 3
cytosol 1

Gene Ontology (GO) - Cellular Components for HRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IDA 15220341
GO:0031093 platelet alpha granule lumen TAS --
GO:0036019 endolysosome IBA --
genes like me logo Genes that share ontologies with HRG: view

Pathways & Interactions for HRG Gene

genes like me logo Genes that share pathways with HRG: view

Gene Ontology (GO) - Biological Process for HRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0002576 platelet degranulation TAS --
GO:0002839 positive regulation of immune response to tumor cell IDA 21215706
GO:0006935 chemotaxis IEA --
GO:0007162 negative regulation of cell adhesion IDA 14744774
genes like me logo Genes that share ontologies with HRG: view

No data available for SIGNOR curated interactions for HRG Gene

Drugs & Compounds for HRG Gene

(14) Drugs for HRG Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
heme Pharma Agonist 0

(9) Additional Compounds for HRG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HRG: view

Transcripts for HRG Gene

mRNA/cDNA for HRG Gene

Unigene Clusters for HRG Gene

Histidine-rich glycoprotein:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HRG Gene

No ASD Table

Relevant External Links for HRG Gene

GeneLoc Exon Structure for
HRG
ECgene alternative splicing isoforms for
HRG

Expression for HRG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HRG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HRG Gene

This gene is overexpressed in Liver (x52.5).

Protein differential expression in normal tissues from HIPED for HRG Gene

This gene is overexpressed in Synovial fluid (15.9), Serum (15.7), Plasma (15.1), and Monocytes (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HRG Gene



Protein tissue co-expression partners for HRG Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HRG Gene:

HRG

SOURCE GeneReport for Unigene cluster for HRG Gene:

Hs.1498

mRNA Expression by UniProt/SwissProt for HRG Gene:

P04196-HRG_HUMAN
Tissue specificity: Expressed in macrophages and in malignant cells. Expressed by the liver and secreted in plasma (at protein level).

Evidence on tissue expression from TISSUES for HRG Gene

  • Liver(4.9)
  • Bone marrow(4)
  • Blood(2.6)
  • Kidney(2.5)

Phenotype-based relationships between genes and organs from Gene ORGANizer for HRG Gene

Germ Layers:
  • mesoderm
Systems:
  • cardiovascular
Organs:
General:
  • blood
  • blood vessel
  • coagulation system
genes like me logo Genes that share expression patterns with HRG: view

Primer Products

Orthologs for HRG Gene

This gene was present in the common ancestor of chordates.

Orthologs for HRG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HRG 34 35
  • 98.67 (n)
cow
(Bos Taurus)
Mammalia HRG 34 35
  • 78.73 (n)
mouse
(Mus musculus)
Mammalia Hrg 35
  • 60 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HRG 35
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HRG 35
  • 41 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HRG 35
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves HRG 35
  • 32 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HRG 35
  • 30 (a)
OneToOne
Species where no ortholog for HRG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HRG Gene

ENSEMBL:
Gene Tree for HRG (if available)
TreeFam:
Gene Tree for HRG (if available)

Paralogs for HRG Gene

(1) SIMAP similar genes for HRG Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for HRG Gene

genes like me logo Genes that share paralogs with HRG: view

No data available for Paralogs for HRG Gene

Variants for HRG Gene

Sequence variations from dbSNP and Humsavar for HRG Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs121918122 Pathogenic, Thrombophilia due to histidine-rich glycoprotein deficiency (THPH11) [MIM:613116] 186,669,945(+) GATCG(A/G)ACAAT intron-variant, reference, missense
rs2276804 Thrombophilia due to histidine-rich glycoprotein deficiency (THPH11) [MIM:613116] 186,675,170(+) TAAAC(C/T)GTGAA intron-variant, reference, missense
rs1000064250 -- 186,676,400(+) TTTTT(A/G)TATCT intron-variant
rs1000168242 -- 186,669,894(+) AGGCA(A/G)GATGC intron-variant
rs1000400441 -- 186,670,023(+) CACAA(G/T)TTCTG intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for HRG Gene

Variant ID Type Subtype PubMed ID
dgv1434e212 CNV loss 25503493
dgv5003n100 CNV loss 25217958
dgv8768n54 CNV loss 21841781
dgv963e214 CNV loss 21293372
esv2759206 CNV loss 17122850
esv29238 CNV loss 19812545
nsv1012615 CNV gain 25217958
nsv4153 CNV insertion 18451855
nsv436928 CNV loss 16327808
nsv437901 CNV loss 16468122
nsv508974 CNV insertion 20534489
nsv516553 CNV loss 19592680
nsv818196 CNV loss 17921354
nsv998724 CNV loss 25217958

Variation tolerance for HRG Gene

Residual Variation Intolerance Score: 95.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.55; 97.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HRG Gene

Human Gene Mutation Database (HGMD)
HRG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HRG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HRG Gene

Disorders for HRG Gene

MalaCards: The human disease database

(4) MalaCards diseases for HRG Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
thrombophilia due to hrg deficiency
  • thrombophilia due to elevated hrg
thrombophilia
  • hypercoagulability state
protein c deficiency
  • hereditary thrombophilia due to congenital protein c deficiency
corneal neovascularization
- elite association - COSMIC cancer census association via MalaCards
Search HRG in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

HRG_HUMAN
  • Thrombophilia due to histidine-rich glycoprotein deficiency (THPH11) [MIM:613116]: A hemostatic disorder characterized by a tendency to thrombosis. {ECO:0000269 PubMed:11057869, ECO:0000269 PubMed:9414276}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for HRG Gene

thrombophilia,with low histidine-rich glycoprotein level

Relevant External Links for HRG

Genetic Association Database (GAD)
HRG
Human Genome Epidemiology (HuGE) Navigator
HRG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HRG
genes like me logo Genes that share disorders with HRG: view

Publications for HRG Gene

  1. High affinity interaction between histidine-rich glycoprotein and the cell surface type ATP synthase on T-cells. (PMID: 19285951) Ohta T. … Wakabayashi S. (Biochim. Biophys. Acta 2009) 3 4 22 64
  2. Regulation of histidine-rich glycoprotein (HRG) function via plasmin- mediated proteolytic cleavage. (PMID: 19712047) Poon I.K. … Parish C.R. (Biochem. J. 2009) 3 4 22 64
  3. Activated platelets provide a functional microenvironment for the antiangiogenic fragment of histidine-rich glycoprotein. (PMID: 19903770) Thulin A. … Olsson A.K. (Mol. Cancer Res. 2009) 3 4 22 64
  4. The anti-angiogenic His/Pro-rich fragment of histidine-rich glycoprotein binds to endothelial cell heparan sulfate in a Zn2+- dependent manner. (PMID: 16436387) Vanwildemeersch M. … Spillmann D. (J. Biol. Chem. 2006) 3 4 22 64
  5. A fragment of histidine-rich glycoprotein is a potent inhibitor of tumor vascularization. (PMID: 14744774) Olsson A.K. … Claesson-Welsh L. (Cancer Res. 2004) 3 4 22 64

Products for HRG Gene

Sources for HRG Gene

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