HRG Gene
protein-coding GIFtS: 61
GCID: GC03P186378
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|
histidine-rich glycoprotein
| |
Aliases
for HRG gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Histidine-Rich Glycoprotein1 2 | | HPRG1 2 3 | | HRGP1 2 | | Histidine-Proline-Rich Glycoprotein2 3 | | THPH112 |
Export aliases for HRG gene to outside databasesPrevious GC identifers: GC03P183155 GC03P187640 GC03P187785 GC03P187704 GC03P187866 GC03P183793 |
Summaries
for HRG gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HRG:
This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. Thephysiological function has not been determined but it is known that the protein binds heme, dyes and divalent metalions. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of theprotein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potentialprothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: HRG_HUMAN, P04196Function: Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin,plasminogen, and divalent metal ions. Binds heparin and heparin/glycosaminoglycans in a zinc-dependent manner. Bindsheparan sulfate on the surface of liver, lung, kidney and heart endothelial cells. Binds to N-sulfated polysaccharidechains on the surface of liver endothelial cells. Inhibits rosette formation. Acts as an adapter protein and isimplicated in regulating many processes such as immune complex and pathogen clearance, cell chemotaxis, cell adhesion,angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis ofnecrotic cells in a heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRGligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda lightchains with different affinities regulating their clearance and inhibiting the formation of insoluble immunecomplexes. Tethers plasminogen to the cell surface. Binds T-cells and alters the cell morphology. Modulatesangiogenesis by blocking the CD6-mediated antiangiongenic effect of thrombospondins, THBS1 and THBS2. Acts as aregulator of the vascular endothelial growth factor (VEGF) signaling pathway; inhibits endothelial cell motility byreducing VEGF-induced complex formation between PXN/paxillin and ILK/integrin-linked protein kinase and by promotinginhibition of VEGF-induced tyrosine phosphorylation of focal adhesion kinases and alpha-actinins in endothelial cells.Also plays a role in the regulation of tumor angiogenesis and tumor immune surveillance. Normalizes tumor vessels andpromotes antitumor immunity by polarizing tumor-associated macrophages, leading to decreased tumor growth andmetastasis
Gene Wiki entry for HRG
|
Genomic Views
for HRG gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HRG gene promoter:
TBP p53 FOXF2 HSF1 (long) NF-kappaB Evi-1 AREB6 HSF1short NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for HRG
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HRG |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q27 Ensembl cytogenetic band: 3q27.3 HGNC cytogenetic band: 3q27HRG Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P186378: view genomic region
(about GC identifiers)
Start:
|
186,378,005 bp from pter |
End:
|
186,396,029 bp from pter |
Size:
|
18,025 bases |
Orientation:
|
plus strand |
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Proteins
for HRG gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HRG_HUMAN, P04196 (See
protein sequence)Recommended Name: Histidine-rich glycoprotein precursor Size: 525 amino acids; 59578 Da
Cofactor: Zinc
Subunit: Interacts (via the HRR domain) with TPM1; the interaction appears to contribute to the antiangiogenicproperties of the HRR domain. Interacts with THBS2; the interaction blocks the antiangiogenic effect of THBS2 withCD36 (By similarity). Interacts with THBS1 (via the TSP type I repeats); the interaction blocks the antiangiogeniceffect of THBS1 with CD3. Interacts with PLG (via its Kringle domains); the interaction tethers PLG to the cellsurface and enhances its activation. Interacts with HPSE; the interaction is enhanced at acidic pH, partially inhibitsbinding of HPSE to cell surface receptors and modulates its enzymatic activity. Interacts (via the HRR domain) withTMP1; the interaction partially mediates the antiangiogenic properties of HRG. Interacts with kappa and lambda lightchains of IgG molecules. Interacts with ATP5A1; the interaction occurs on the surface of T-cells and alters their cellmorphology in concert with CONA. Binds IgG molecules containing kappa and lambda light chains and inhibits theformation of insoluble immunoglobulin complexes. Interacts with F12; the interaction, which is enhanced in thepresence of zinc ions and inhibited by heparin-binding to HRG, inhibits factor XII autoactivation andcontact-initiated coagulation
Subcellular location: Secreted
Secondary accessions: B9EK35 D3DNU7Explore the universe of human proteins at neXtProt for HRG: NX_P04196
Post-translational modifications:
Proteolytic cleavage produces several HRG fragments which are mostly disulfide-linked and, therefore, not released.Cleavage by plasmin is inhibited in the presence of heparin, zinc ions or in an acidic environment. Cleavage reducesbinding of HRG to heparan sulfate, but enhances the ability of HRG to bind and tether plasminogen to the cell surface.On platelet activation, releases a 33 kDa antiangiogenic peptide which encompasses the HRR. Also cleaved in theC-terminal by plasmin1
N-glycosylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P04196
HRG Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000403.1
ENSEMBL proteins: ENSP00000232003 Reactome Protein details: P04196
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
TAS | -- | | GO:0005886 | plasma membrane |
TAS | -- | | GO:0031093 | platelet alpha granule lumen |
TAS | -- |
HRG for ontologies About GeneDecksing
HRG Antibody Products:
Assay Products for HRG: |
Protein
Domains /
Families
for HRG gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HRG for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P04196ProtoNet protein and cluster: P04196 1 Blocks protein family: IPB000010 Cysteine protease inhibitor
UniProtKB/Swiss-Prot: HRG_HUMAN, P04196Domain: The His/Pro-rich (HRR) region contains approximately 12 tandem internal repeats of the 5-residue G[H/P][H/P]PHconsensus sequence. HRR binds heparan sulfate and possesses antiangiogenic, antibacterial and antifungal propertiesthrough binding Candida cells, and preferentially lysing the ergosterol-containing liposomes at low pH. The tandemrepeats also bind divalent metal ions and hemeDomain: The cystatin domains can also bind heparan sulfate. Binding is enhanced in the presence of zinc ionsSimilarity: Contains 2 cystatin domains |
Function
for HRG gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: HRG_HUMAN, P04196Function: Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin,plasminogen, and divalent metal ions. Binds heparin and heparin/glycosaminoglycans in a zinc-dependent manner. Bindsheparan sulfate on the surface of liver, lung, kidney and heart endothelial cells. Binds to N-sulfated polysaccharidechains on the surface of liver endothelial cells. Inhibits rosette formation. Acts as an adapter protein and isimplicated in regulating many processes such as immune complex and pathogen clearance, cell chemotaxis, cell adhesion,angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis ofnecrotic cells in a heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRGligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda lightchains with different affinities regulating their clearance and inhibiting the formation of insoluble immunecomplexes. Tethers plasminogen to the cell surface. Binds T-cells and alters the cell morphology. Modulatesangiogenesis by blocking the CD6-mediated antiangiongenic effect of thrombospondins, THBS1 and THBS2. Acts as aregulator of the vascular endothelial growth factor (VEGF) signaling pathway; inhibits endothelial cell motility byreducing VEGF-induced complex formation between PXN/paxillin and ILK/integrin-linked protein kinase and by promotinginhibition of VEGF-induced tyrosine phosphorylation of focal adhesion kinases and alpha-actinins in endothelial cells.Also plays a role in the regulation of tumor angiogenesis and tumor immune surveillance. Normalizes tumor vessels andpromotes antitumor immunity by polarizing tumor-associated macrophages, leading to decreased tumor growth andmetastasis Genatlas biochemistry entry for HRG:histidine-rich glycoprotein (plasma),binding plasminogen and heparin,cystatin (cysteine proteinase inhibitor)superfamily,interacting with plasma proteins involved in blood coagulation and fibronolysis
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HRG
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for HRG | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HRG |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRG |
Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table
HRG for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for HRG:
Animal Models:
Mouse knock-out Hrgtm1Wja for HRG
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Hrg):
HRG for phenotypes About GeneDecksing
|
Pathways & Interactions
for HRG gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Platelet degranulation | | | 2 | Platelet activation, signaling and aggregation | | | 3 | Expression of PAI-1 | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 
Reactome Pathways for HRG
HRG for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HRG
STRING Interaction
Network Preview (showing 5 interactants - click image to see 14)
5/17 Interacting proteins for HRG (P041961, 3 ENSP000002320034) via UniProtKB, MINT, STRING, and/or I2D (see all 17)About this table
Gene Ontology (GO): 5/27 biological process terms (GO ID links to tree view) (see all 27): About this table
HRG for ontologies About GeneDecksing
|
Drugs & Compounds
for HRG gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
HRG for compounds About GeneDecksing
 Browse Tocris compounds for HRG
1 HMDB Compound for HRG About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Heme | (protoporphyrinato)iron (see all 19) | 14875-96-8 | -- |
10/22 Novoseek chemical compound relationships for HRG gene (see all 22) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| kininogen |
78.1 |
25 |
19273244 (2), 17655823 (1), 11204593 (1), 2107324 (1) (see all 10) |
| heparin |
60 |
92 |
19786011 (8), 9153200 (6), 12024108 (6), 9488672 (5) (see all 24) |
| fibrinogen |
58.6 |
28 |
19878090 (5), 8562978 (2), 8987550 (2), 15748207 (1) (see all 13) |
| heparan sulfate |
54.5 |
23 |
16436387 (3), 19712047 (2), 19903770 (1), 16107330 (1) (see all 8) |
| dermatan sulfate |
52.2 |
12 |
1554154 (5), 7833476 (1), 9488672 (1) |
| histidine |
51.9 |
27 |
19903770 (3), 7873529 (3), 9488672 (3), 1561009 (2) (see all 12) |
| epsilon aminocaproic acid |
47.7 |
7 |
10946092 (4), 9102401 (1) |
| hydroxyproline |
38.1 |
6 |
9512767 (4) |
| zinc |
36.5 |
65 |
9153200 (7), 11372684 (6), 8690451 (6), 12024108 (5) (see all 11) |
| lysine |
33.6 |
12 |
9102401 (2), 7873529 (2), 15220341 (1), 9488672 (1) |
Search CenterWatch for drugs/clinical trials and news about HRG
|
Transcripts
for HRG gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HRG gene: NM_000412.2 Unigene Cluster for HRG: Histidine-rich glycoprotein Hs.1498 [show with all ESTs]Unigene Representative Sequence: CR7493023 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000468154 ENST00000232003(uc003fqq.3) ENST00000495413
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HRG (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HRG
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HRG (NM_000412) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HRG | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HRG |
Additional cDNA sequence: AK313381.1 BC069574.1 BC150591.1 CR749302.1 8 DOTS entries: DT.455089 DT.92428066 DT.92428064 DT.100779786 DT.92428061 DT.95158654 DT.92428065 DT.95158651 24/106 AceView cDNA sequences (see all 106): CB156959 BC069574 CB115410 NM_000412 C21004 AV651187 T55861 N68297 T69219 T74779 CB153786 T55912 BI517904 AV651674 CR749302 AV650546 T67251 CB163837 H97733 AI378312 T39993 AI033102 BX955758 R96642
GeneLoc Exon Structure
|
Expression
for HRG gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HRG expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTTTACAC
About this image
See HRG Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HRG
SOURCE GeneReport for Unigene cluster: Hs.1498
UniProtKB/Swiss-Prot: HRG_HUMAN, P04196Tissue specificity: Expressed in macrophages and in malignant cells. Expressed by the liver and secreted in plasma (atprotein level)
SABiosciences Expression via Pathway-Focused PCR Array including HRG:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HRG
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRG |
Orthologs
for HRG gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for HRG gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for HRG (if available)
TreeFam Gene Tree for HRG (if available) |
Paralogs
for HRG gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HRG gene
1 SIMAP similar gene for HRG using alignment to 1 protein entry: HRG_HUMAN:DKFZp779H1622
HRG for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for HRG
PGOHUM00000238292 PGOHUM00000238293
|
Genomic Variants
for HRG gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HRG (186378005 - 186396029 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for HRG
7 CNVs: 1380 63680 2488 3467 1656 10027 51029
Human Gene Mutation Database (HGMD): HRG
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HRG |
|
Disorders
/ Diseases
for HRG gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HRG for disorders About GeneDecksing
OMIM gene information: 142640
OMIM disorders: 613116
UniProtKB/Swiss-Prot: HRG_HUMAN, P04196
Defects in HRG are the cause of thrombophilia due to histidine-rich glycoprotein deficiency (THPH11)[MIM:613116]. A hemostatic disorder characterized by a tendency to thrombosis
20/22  diseases for HRG (see all 22): About MalaCardsthrombophilia thrombophilia due to elevated hrg thrombophilia due to hrg deficiency protein c deficiency
graft versus host disease corneal neovascularization retinal vein occlusion myocardial infarction
venous thrombosis hyperhomocysteinemia rheumatoid arthritis thrombosis
thromboembolism nephrotic syndrome diabetes mellitus hepatitis b
arthritis twinning retinitis hepatitis
10/13 Novoseek disease relationships for HRG gene (see all 13) About this table
Genatlas disease: HRG thrombophilia,with low histidine-rich glycoprotein level
Human Genome Epidemiology (HuGE) Navigator: HRG (106 documents)
Export disorders for HRG gene to outside databases
|
Publications
for HRG gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HRG gene, integrated from 9 sources (see all 167):
(articles sorted by number of sources associating them with HRG) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Regulation of histidine-rich glycoprotein (HRG) funct ion via plasmin-mediated proteolytic cleavage. (PubMed id 19712047)1, 2, 9 Poon I.K....Parish C.R. (2009)
- Differential binding of histidine-rich glycoprotein (HRG) to human IgG subclasses and IgG molecules containing kappa and lambda light chains. (PubMed id 10514432)1, 2, 9 Gorgani N.N....Altin J.G. (1999)
- HRG Tokushima: molecular and cellular characterization of histidine- rich glycoprotein (HRG) deficiency. (PubMed id 9414276)1, 2, 9 Shigekiyo T.... Koide T. (1998)
- A fragment of histidine-rich glycoprotein is a potent inhibitor of tumor vascularization. (PubMed id 14744774)1, 2, 9 Olsson A.K....Claesson-Welsh L. (2004)
- Histidine-rich glycoprotein inhibits the antiangiogenic effect of thrombospondin-1. (PubMed id 11134179)1, 2, 9 Simantov R....Silverstein R.L. (2001)
- Plasminogen is tethered with high affinity to the cell surface by the plasma protein, histidine-rich glycoprotein. (PubMed id 15220341)1, 2, 9 Jones A.L....Parish C.R. (2004)
- High affinity interaction between histidine-rich glycoprotein and the cell surface type ATP synthase on T-cells. (PubMed id 19285951)1, 2, 9 Ohta T....Wakabayashi S. (2009)
- Activated platelets provide a functional microenviron ment for the antiangiogenic fragment of histidine-rich glycoprotein. (PubMed id 19903770)1, 2, 9 Thulin A....Olsson A.K. (2009)
- The anti-angiogenic His/Pro-rich fragment of histidine-rich glycoprotein binds to endothelial cell heparan sulfate in a Zn2+-dependent manner. (PubMed id 16436387)1, 2, 9 Vanwildemeersch M....Spillmann D. (2006)
- Evidence for the absence of intron H of the histidine-rich glycoprotein (HRG) gene: genetic mapping and in situ localization of HRG to chromosome 3q28-q29. (PubMed id 8188234)1, 2, 9 Hennis B.C.... Kluft C. (1994)
|
External Searches for HRG gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HRG gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HRG gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HRG gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HRG | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HRG gene:
Search GeneIP for patents involving HRG
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for HRG gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HRG | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HRG | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HRG | | | OriGene Protein Over-expression Lysate for HRG | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HRG | | OriGene 3'-UTR Clone for HRG | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HRG | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HRG | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for HRG | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HRG | | OriGene Custom Protein Services for HRG | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HRG | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HRG | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HRG | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HRG | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HRG | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HRG |
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| | | | Search Tocris compounds for HRG |
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 | | | HRG Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRG |
|  |  |  | | | | ThermoFisher Antibodies for HRG |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HRG |
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