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Aliases for HRCT1 Gene

Aliases for HRCT1 Gene

  • Histidine Rich Carboxyl Terminus 1 2 3 5
  • Histidine-Rich Carboxyl Terminus Protein 1 3
  • LGLL338 3
  • PRO537 3
  • UNQ338 3

External Ids for HRCT1 Gene

Summaries for HRCT1 Gene

GeneCards Summary for HRCT1 Gene

HRCT1 (Histidine Rich Carboxyl Terminus 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HRCT1 Gene

Genomics for HRCT1 Gene

Regulatory Elements for HRCT1 Gene

Enhancers for HRCT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G035904 1.8 FANTOM5 Ensembl ENCODE dbSUPER 19.7 +2.0 1976 7.4 FOXA2 SIN3A ZNF48 YY1 SLC30A9 ZNF121 GLIS2 GATA2 ZNF143 FOS HRCT1 SPAAR TMEM8B OR13J1 FAM221B NDUFA5P4 ENSG00000227388 NPR2 SPAG8 OR2S1P
GH09G036398 1.3 Ensembl ENCODE 10.6 +494.3 494309 4.7 HDGF FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207 RNF38 OR13E1P HRCT1 GLIPR2 HMGB3P24 MRPS21P4
GH09G035844 1.3 Ensembl ENCODE dbSUPER 10.1 -60.8 -60840 3.3 HDAC1 HDGF FOXA2 ATF1 GATA2 FOS RELB ETV6 IKZF2 CREM TMEM8B HRCT1 OR13E1P LINC00950 FAM221B
GH09G035913 1.6 Ensembl ENCODE dbSUPER 7.9 +11.1 11050 7.7 HDGF PKNOX1 ARNT ARID4B YBX1 ZBTB7B YY1 ZNF766 ZNF207 ZNF548 YBX1P10 GBA2 SPAAR RECK NDUFA5P4 OR13J1 FAM221B TMEM8B SPAG8 ENSG00000227388
GH09G035161 1.1 ENCODE 10.6 -743.9 -743859 2.6 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF263 SP3 SP5 NFYC UNC13B OR13E1P FAM214B HRCT1 GC09M035178
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HRCT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for HRCT1 Gene

Chromosome:
9
Start:
35,906,192 bp from pter
End:
35,907,141 bp from pter
Size:
950 bases
Orientation:
Plus strand

Genomic View for HRCT1 Gene

Genes around HRCT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HRCT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HRCT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HRCT1 Gene

Proteins for HRCT1 Gene

  • Protein details for HRCT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXD1-HRCT1_HUMAN
    Recommended name:
    Histidine-rich carboxyl terminus protein 1
    Protein Accession:
    Q6UXD1
    Secondary Accessions:
    • B7ZBJ1

    Protein attributes for HRCT1 Gene

    Size:
    115 amino acids
    Molecular mass:
    13183 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HRCT1 Gene

Post-translational modifications for HRCT1 Gene

No Post-translational modifications

Other Protein References for HRCT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HRCT1 Gene

Domains & Families for HRCT1 Gene

Protein Domains for HRCT1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HRCT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HRCT1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for HRCT1 Gene

Function for HRCT1 Gene

Phenotypes for HRCT1 Gene

GenomeRNAi human phenotypes for HRCT1:
genes like me logo Genes that share phenotypes with HRCT1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for HRCT1

CRISPR Products

miRNA for HRCT1 Gene

miRTarBase miRNAs that target HRCT1

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HRCT1 Gene

Localization for HRCT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HRCT1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HRCT1 gene
Compartment Confidence
extracellular 3
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for HRCT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HRCT1: view

Pathways & Interactions for HRCT1 Gene

SuperPathways for HRCT1 Gene

No Data Available

Interacting Proteins for HRCT1 Gene

Gene Ontology (GO) - Biological Process for HRCT1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for HRCT1 Gene

Drugs & Compounds for HRCT1 Gene

No Compound Related Data Available

Transcripts for HRCT1 Gene

mRNA/cDNA for HRCT1 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HRCT1 Gene

Histidine rich carboxyl terminus 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for HRCT1 Gene

No ASD Table

Relevant External Links for HRCT1 Gene

GeneLoc Exon Structure for
HRCT1
ECgene alternative splicing isoforms for
HRCT1

Expression for HRCT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HRCT1 Gene

mRNA differential expression in normal tissues according to GTEx for HRCT1 Gene

This gene is overexpressed in Artery - Tibial (x5.7), Artery - Aorta (x5.3), and Colon - Transverse (x4.0).

Protein differential expression in normal tissues from HIPED for HRCT1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HRCT1 Gene



Protein tissue co-expression partners for HRCT1 Gene

NURSA nuclear receptor signaling pathways regulating expression of HRCT1 Gene:

HRCT1

SOURCE GeneReport for Unigene cluster for HRCT1 Gene:

Hs.208081
genes like me logo Genes that share expression patterns with HRCT1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HRCT1 Gene

Orthologs for HRCT1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for HRCT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HRCT1 34 35
  • 96.9 (n)
dog
(Canis familiaris)
Mammalia HRCT1 35
  • 63 (a)
OneToOne
Species where no ortholog for HRCT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HRCT1 Gene

ENSEMBL:
Gene Tree for HRCT1 (if available)
TreeFam:
Gene Tree for HRCT1 (if available)

Paralogs for HRCT1 Gene

No data available for Paralogs for HRCT1 Gene

Variants for HRCT1 Gene

Sequence variations from dbSNP and Humsavar for HRCT1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000029006 -- 35,905,823(+) CCGTT(A/G)TCAGC upstream-variant-2KB
rs1000626569 -- 35,904,501(+) AAGTT(C/T)TTCAA nc-transcript-variant, upstream-variant-2KB
rs1000831865 -- 35,904,793(+) TTGGT(C/T)GAAGG intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1001375806 -- 35,904,524(+) AAGGT(C/T)CTGCC nc-transcript-variant, upstream-variant-2KB
rs1001478028 -- 35,904,697(+) GAGTT(C/G)TTACT intron-variant, nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HRCT1 Gene

Variant ID Type Subtype PubMed ID
nsv1125318 OTHER inversion 24896259
nsv831546 CNV loss 17160897

Variation tolerance for HRCT1 Gene

Residual Variation Intolerance Score: 84.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.12; 92.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HRCT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HRCT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HRCT1 Gene

Disorders for HRCT1 Gene

Relevant External Links for HRCT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HRCT1

No disorders were found for HRCT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HRCT1 Gene

Publications for HRCT1 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 4 64

Products for HRCT1 Gene

Sources for HRCT1 Gene

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