HRC Gene
protein-coding GIFtS : 51
GCID: GC19 M049654
histidine rich calcium binding protein (Previous name: histidine-rich calcium-binding protein )
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Aliasesfor HRC gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Histidine Rich Calcium Binding Protein 1 2 MGC1332361 Histidine-Rich Calcium-Binding Protein1 Sarcoplasmic Reticulum Histidine-Rich Calcium-Binding Protein2 HCP3
Export aliases for HRC gene to outside databases Previous GC identifers: GC19M050312 GC19M050022 GC19M054330 GC19M054346 GC19M046030
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Summariesfor HRC gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for HRC : This gene encodes a luminal sarcoplasmic reticulum protein identified by its ability to bind low-density lipoprotein with high affinity. The protein interacts with the cytoplasmic domain of triadin, the main transmembrane protein of the junctional sarcoplasmic reticulum (SR) of skeletal muscle. The protein functions in the regulation of releasable calcium into the SR. (provided by RefSeq, Sep 2008) UniProtKB/Swiss-Prot: SRCH_HUMAN, P23327 Function : May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiacmuscle Gene Wiki entry for HRC
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Genomic Viewsfor HRC gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000019.9 NC_018930.1 NT_011109.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the HRC gene promoter: RFX1 AML1a MAZR p300 Bach2 AP-4 Arnt AREB6 ZID MRF-2 Other transcription factors Search SABiosciences Chromatin IP Primers for HRC Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat HRC
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 19q13.3 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.3 HRC Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 19 GeneLoc Exon Structure
GeneLoc location for GC19M049654: view genomic region
(about GC identifiers )
Start:
49,654,455 bp from pter
End:
49,658,681 bp from pter
Size:
4,227 bases
Orientation:
minus strand
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Proteinsfor HRC gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: SRCH_HUMAN, P23327 (See
protein sequence )Recommended Name: Sarcoplasmic reticulum histidine-rich calcium-binding protein precursor Size : 699 amino acids; 80244 Da
Subcellular location : Sarcoplasmic reticulum lumen
Secondary accessions : Q504Y6Explore the universe of human proteins at neXtProt for HRC: NX_P23327 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P23327 HRC Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_002143.1 ENSEMBL proteins: ENSP00000252825 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0033017 sarcoplasmic reticulum membrane
IEA -- GO:0033018 sarcoplasmic reticulum lumen
IEA --
HRC for ontologies About GeneDecksing HRC Antibody Products: Assay Products for HRC:
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Protein
Domains / Familiesfor HRC gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
HRC for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P23327 ProtoNet protein and cluster: P23327
UniProtKB/Swiss-Prot: SRCH_HUMAN, P23327 Similarity : To rabbit HRC
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Functionfor HRC gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: SRCH_HUMAN, P23327 Function : May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiacmuscle
Genatlas biochemistry entry for HRC : histidine-rich calcium binding protein (sarcoplasmic reticulum,luminal) Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for HRC (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for HRCOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: HRC (NM_002152 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HRC Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat HRC
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRC
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
HRC for ontologies About GeneDecksing Animal Models: Mouse knock-out Hrc tm1Blk for HRC 6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Hrc) :
HRC for phenotypes About GeneDecksing
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Pathways & Interactionsfor HRC gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HRC STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)3 Interacting proteins for HRC (P23327 3 ENSP00000252825 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 3 biological process terms (GO ID links to tree view) : About this table
HRC for ontologies About GeneDecksing
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Drugs & Compoundsfor HRC gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
HRC for compounds About GeneDecksing Browse Tocris compounds for HRC 1 HMDB Compound for HRC About this table 2 Novoseek chemical compound relationships for HRC gene About this table
Search CenterWatch for drugs/clinical trials and news about HRC / SRCH
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Transcriptsfor HRC gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for HRC gene: NM_002152.2 Unigene Cluster for HRC:
Histidine rich calcium binding protein Hs.436885 [show with all ESTs ] Unigene Representative Sequence: NM_002152 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000252825 (uc002pmv.3 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for HRC (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for HRCOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: HRC (NM_002152 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HRC Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat HRC
Additional cDNA sequence: AK300706.1 BC069795.1 BC069802.1 BC094691.1 BC112355.1 M60052.1
3 DOTS entries : DT.306252 DT.101975522
DT.70102010 24/29 AceView cDNA sequences (see all 29 ):
BU734330 AJ709091 AJ708095 BC069795 BX095911 AW451524 M60052 BC069802 NM_002152 CF552507 BX503233 BX501657 CF552455 BX503203 BX501760 AI769340 F26849 BX501653 F29472 AI803012 AW611587 BF475747 BM716386 CD103822 GeneLoc Exon Structure 2 Alternative Splicing Database (ASD) splice patterns (SP) for HRC About this scheme ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 SP1 :           -       SP2 :                
ECgene alternative splicing isoforms for HRC
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Expression for HRC gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section HRC expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image HRC expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See HRC Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for HRC SOURCE GeneReport for Unigene cluster: Hs.436885 SABiosciences Custom PCR Arrays for HRC Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for HRCBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat HRC QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat HRC QIAGEN QuantiFast Probe-based Assays in human , mouse , rat HRC In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRC
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Orthologsfor HRC gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for HRC gene from 4/10 species (see all 10 ) About this table
ENSEMBL Gene Tree for HRC (if available)TreeFam Gene Tree for HRC (if available)
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Paralogsfor HRC gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for HRC gene IWS1 2
HRC for paralogs About GeneDecksing
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Genomic Variantsfor HRC gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 19 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for HRC (49654455 - 49658681 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for HRC 2 CNVs : 5109 32261 Human Gene Mutation Database (HGMD) : HRC SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing HRC
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Disorders
/ Diseasesfor HRC gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
HRC for disorders About GeneDecksing
OMIM gene information: 142705
OMIM disorders : --4 diseases for HRC : About MalaCards mixed glioma dilated cardiomyopathy conduction disease cardiomyopathy 1 Novoseek disease relationship for HRC gene About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
niddm
22.9
3
7913686 (2)
Human Genome Epidemiology (HuGE) Navigator: HRC (1 document)Export disorders for HRC gene to outside databases
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Publicationsfor HRC gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for HRC gene, integrated from 9 sources (see all 28 ): (articles sorted by number of sources associating them with HRC) Utopia : connect your pdf to the dynamic world of online information
cDNA and genomic cloning of HRC, a human sarcoplasmic reticulum protein, and localization of the gene to human chromosome 19 and mouse chromosome 7. (PubMed id 2037293) 1 , 2 , 3, 9 Hofmann S.L.... Francke U. (1991) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Interaction of HRC (histidine-rich Ca(2+)-binding protein) and triadin in the lumen of sarcoplasmic reticulum. (PubMed id 11504710) 1 , 9 Lee H.G....Park W.J. (2001) Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase. (PubMed id 17526652) 1 , 9 Arvanitis D.A....Kranias E.G. (2007) Regulation of myocardial function by histidine-rich, calcium-binding protein. (PubMed id 15191886) 1 , 9 Fan G.C....Kranias E.G. (2004) The Ser96Ala variant in histidine-rich calcium-binding protein is associated with life-threatening ventricular arrhythmias in idiopathic dilated cardiomyopathy. (PubMed id 18617481) 1 , 9 Arvanitis D.A....Kranias E.G. (2008) Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590) 1 Emanuele M.J....Elledge S.J. (2011) Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348) 1 Barbe L....Andersson-Svahn H. (2008) HRC is a direct transcriptional target of MEF2 during cardiac, skeletal, and arterial smooth muscle development in vivo. (PubMed id 15082771) 1 Anderson J.P....Black B.L. (2004) Increased Ca2+ storage capacity in the sarcoplasmic reticulum by overexpression of HRC (histidine-rich Ca2+ binding protein). (PubMed id 12480542) 1 Kim E....Park W.J. (2003)
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External Searches for HRC gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing HRC gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing HRC gene
(According to HUGE )
About This Section --
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Specialized Databases showing HRC gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for HRC Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for HRC gene: Search GeneIP for patents involving HRC GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor HRC gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for HRC OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for HRC OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for HRC Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for HRC Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for HRC OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for HRC Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for HRC OriGene Custom Protein Services for HRC OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HRC QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing HRC QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat HRC QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat HRC QIAGEN QuantiFast Probe-based Assays in human , mouse , rat HRC QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat HRC
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRC
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat HRC
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