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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HRC Gene

protein-coding   GIFtS: 51
GCID: GC19M049654

histidine rich calcium binding protein

(Previous name: histidine-rich calcium-binding protein )
 Explore 4 diseases affiliated with
HRC via our new
 Human Malady Compendium 
Biological research products
for HRC
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Histidine Rich Calcium Binding Protein1 2
MGC1332361
Histidine-Rich Calcium-Binding Protein1
Sarcoplasmic Reticulum Histidine-Rich Calcium-Binding Protein2
HCP3

External Ids:    HGNC: 51781   Entrez Gene: 32702   Ensembl: ENSG000001305287   OMIM: 1427055   UniProtKB: P233273   

Export aliases for HRC gene to outside databases

Previous GC identifers: GC19M050312 GC19M050022 GC19M054330 GC19M054346 GC19M046030


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HRC:
This gene encodes a luminal sarcoplasmic reticulum protein identified by its ability to bind low-density lipoprotein
with high affinity. The protein interacts with the cytoplasmic domain of triadin, the main transmembrane protein of
the junctional sarcoplasmic reticulum (SR) of skeletal muscle. The protein functions in the regulation of releasable
calcium into the SR. (provided by RefSeq, Sep 2008)

UniProtKB/Swiss-Prot: SRCH_HUMAN, P23327
Function: May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac
muscle

Gene Wiki entry for HRC


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HRC gene promoter:
         RFX1   AML1a   MAZR   p300   Bach2   AP-4   Arnt   AREB6   ZID   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHRC promoter sequence
   Search SABiosciences Chromatin IP Primers for HRC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HRC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3

HRC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HRC gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M049654:  view genomic region     (about GC identifiers)

Start:
49,654,455 bp from pter      End:
49,658,681 bp from pter
Size:
4,227 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SRCH_HUMAN, P23327 (See protein sequence)
Recommended Name: Sarcoplasmic reticulum histidine-rich calcium-binding protein precursor  
Size: 699 amino acids; 80244 Da
Subcellular location: Sarcoplasmic reticulum lumen
Secondary accessions: Q504Y6

Explore the universe of human proteins at neXtProt for HRC: NX_P23327

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P23327

  • HRC Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002143.1  
    ENSEMBL proteins: 
     ENSP00000252825  

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    Uscn Proteins for HRC

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0033017sarcoplasmic reticulum membrane IEA--
    GO:0033018sarcoplasmic reticulum lumen IEA--


    HRC for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    HRC for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR019552 Hist_rich_Ca-bd
     IPR015666 His-rich_Ca-bd

    Graphical View of Domain Structure for InterPro Entry P23327

    ProtoNet protein and cluster: P23327

    UniProtKB/Swiss-Prot: SRCH_HUMAN, P23327
    Similarity: To rabbit HRC


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: SRCH_HUMAN, P23327
    Function: May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac
    muscle

         Genatlas biochemistry entry for HRC:
    histidine-rich calcium binding protein (sarcoplasmic reticulum,luminal)

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate HRC:
    hsa-miR-539
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    Inhib. RNA
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    OriGene shRNA RFP: HRC
    OriGene siRNA: HRC
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRC

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding TAS2037293


    HRC for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Hrctm1Blk for HRC
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hrc):
     adipose tissue  behavior/neurological  cardiovascular system  growth/size  homeostasis/metabolism 
     muscle 

    HRC for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HRC

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for HRC (P233273 ENSP000002528254) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRDNQ130613I2D: score=2 
    KNCNENSP000003796074STRING: ENSP00000379607
    --ENSP000003812274STRING: ENSP00000381227
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006936muscle contraction TAS2037293
    GO:0008016regulation of heart contraction IEA--
    GO:0055074calcium ion homeostasis IEA--


    HRC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HRC for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HRC

    1 HMDB Compound for HRC    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    2 Novoseek chemical compound relationships for HRC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ryanodine 63.9 3 15191886 (2), 17526652 (1)
    calcium 39 17 1527222 (3), 10512736 (2), 10531621 (1), 10398759 (1) (see all 9)

    Search CenterWatch for drugs/clinical trials and news about HRC / SRCH 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HRC gene: 
    NM_002152.2  

    Unigene Cluster for HRC:

    Histidine rich calcium binding protein
    Hs.436885  [show with all ESTs]
    Unigene Representative Sequence: NM_002152
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000252825(uc002pmv.3)

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    1 QIAGEN miScript miRNA Assays for microRNA that regulate HRC:
    hsa-miR-539
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    OriGene shRNA RFP: HRC
    OriGene siRNA: HRC
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    Clone
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    Additional cDNA sequence: 

    AK300706.1 BC069795.1 BC069802.1 BC094691.1 BC112355.1 M60052.1 

    3 DOTS entries:

    DT.306252  DT.101975522  DT.70102010 

    24/29 AceView cDNA sequences (see all 29):

    BU734330 AJ709091 AJ708095 BC069795 BX095911 AW451524 M60052 BC069802 
    NM_002152 CF552507 BX503233 BX501657 CF552455 BX503203 BX501760 AI769340 
    F26849 BX501653 F29472 AI803012 AW611587 BF475747 BM716386 CD103822 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for HRC    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6
    SP1:                                -               
    SP2:                                                


    ECgene alternative splicing isoforms for HRC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HRC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    HRC expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneZeugopod Epiphyseal EndChondrocytesBone, Cartilage
    KidneyUreteric BudUreteric Bud Tip CellsKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HRC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HRC

    SOURCE GeneReport for Unigene cluster: Hs.436885
        SABiosciences Custom PCR Arrays for HRC
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HRC gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hrc1 , 5 histidine rich calcium binding protein1, 5 68.36(n)1
    54.94(a)1
      7 (29.26 cM)5
    154641  NM_010473.21  NP_034603.21 
     453352905 
    zebrafish
    (Danio rerio)
    Actinopterygii hrc1 Hrc protein 48.65(n)
    35(a)
      553296  XM_002663895.2  XP_002663941.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG328296
    CG168006
    --
    18(a)
    13(a)
    many → 1
    many → 1
    2L(6915581-6916445)
    2L(12966749-12967788)
    worm
    (Caenorhabditis elegans)
    Secernentea F40F8.51 Protein F40F8.5 42.81(n)
    27.37(a)
      174702  NM_063987.5  NP_496388.3 


    ENSEMBL Gene Tree for HRC (if available)
    TreeFam Gene Tree for HRC (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HRC gene
    IWS12  

    HRC for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/223 NCBI SNPs in HRC are shown (see all 223    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs754068081,2
    --46035174(+) CAAAGA/GCTAGA 2 -- us2k10--------
    rs129734761,2
    H--46035189(+) TAGCAG/AGTTTT 2 -- us2k14Minor allele frequency- A:0.00NS EA 420
    rs1135375591,2
    C,--46036917(+) CTCCCC/TTGTGT 1 -- us2k10--------
    rs80441,2
    C,F,A,H,--49654006(+) GCGGGG/TTCCCC 2 -- ut31 ds500116Minor allele frequency- T:0.42MN NA NS EA WA 1100
    rs350442861,2
    C,--49654301(+) ACTGA-/TTTTTT 2 -- ds50011Minor allele frequency- T:0.00CSA 2
    rs1894545111,2
    --49654315(+) TGCGGA/GGGGGG 2 -- ds50010--------
    rs1820429461,2
    --49654319(+) GGGGGG/TGGGGG 2 -- ds50010--------
    rs1393578431,2
    --49654364(+) AGGCCC/TCTCAT 2 -- ds50010--------
    rs22780041,2
    C,F,A,H,--49654421(+) ATGCCC/TTGAGA 2 -- ds500126Minor allele frequency- T:0.35EA NA NS WA 3942
    rs1859240501,2
    --49654449(+) TGACAA/GTGAGG 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for HRC (49654455 - 49658681 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for HRC
         2 CNVs: 5109 32261
    Human Gene Mutation Database (HGMD): HRC

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    HRC for disorders           About GeneDecksing

    OMIM gene information: 142705    OMIM disorders: --

    4 diseases for HRC:    About MalaCards
    mixed glioma    dilated cardiomyopathy    conduction disease    cardiomyopathy

    1 Novoseek disease relationship for HRC gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    niddm 22.9 3 7913686 (2)

    Human Genome Epidemiology (HuGE) Navigator: HRC (1 document)

    Export disorders for HRC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HRC gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with HRC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA and genomic cloning of HRC, a human sarcoplasmic reticulum protein, and localization of the gene to human chromosome 19 and mouse chromosome 7. (PubMed id 2037293)1, 2, 3, 9 Hofmann S.L.... Francke U. (1991)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Interaction of HRC (histidine-rich Ca(2+)-binding protein) and triadin in the lumen of sarcoplasmic reticulum. (PubMed id 11504710)1, 9 Lee H.G....Park W.J. (2001)
    4. Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase. (PubMed id 17526652)1, 9 Arvanitis D.A....Kranias E.G. (2007)
    5. Regulation of myocardial function by histidine-rich, calcium-binding protein. (PubMed id 15191886)1, 9 Fan G.C....Kranias E.G. (2004)
    6. The Ser96Ala variant in histidine-rich calcium-binding protein is associated with life-threatening ventricular arrhythmias in idiopathic dilated cardiomyopathy. (PubMed id 18617481)1, 9 Arvanitis D.A....Kranias E.G. (2008)
    7. Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    9. HRC is a direct transcriptional target of MEF2 during cardiac, skeletal, and arterial smooth muscle development in vivo. (PubMed id 15082771)1 Anderson J.P....Black B.L. (2004)
    10. Increased Ca2+ storage capacity in the sarcoplasmic reticulum by overexpression of HRC (histidine-rich Ca2+ binding protein). (PubMed id 12480542)1 Kim E....Park W.J. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3270 HGNC: 5178 AceView: HRC Ensembl:ENSG00000130528 euGenes: HUgn3270
    ECgene: HRC H-InvDB: HRC

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HRC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HRC gene:
    Search GeneIP for patents involving HRC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    von Willebrand factor
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