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HRC Gene

protein-coding   GIFtS: 54
GCID: GC19M049654

Histidine Rich Calcium Binding Protein

(Previous name: histidine-rich calcium-binding protein)
  See HRC-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Histidine Rich Calcium Binding Protein1 2
Histidine-Rich Calcium-Binding Protein1
Sarcoplasmic Reticulum Histidine-Rich Calcium-Binding Protein2
HCP3

External Ids:    HGNC: 51781   Entrez Gene: 32702   Ensembl: ENSG000001305287   OMIM: 1427055   UniProtKB: P233273   

Export aliases for HRC gene to outside databases

Previous GC identifers: GC19M050312 GC19M050022 GC19M054330 GC19M054346 GC19M046030


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HRC Gene:
This gene encodes a luminal sarcoplasmic reticulum protein identified by its ability to bind low-density
lipoprotein with high affinity. The protein interacts with the cytoplasmic domain of triadin, the main
transmembrane protein of the junctional sarcoplasmic reticulum (SR) of skeletal muscle. The protein functions in
the regulation of releasable calcium into the SR. (provided by RefSeq, Sep 2008)

GeneCards Summary for HRC Gene:
HRC (histidine rich calcium binding protein) is a protein-coding gene. Diseases associated with HRC include mixed glioma. GO annotations related to this gene include ATPase binding and calcium ion binding.

UniProtKB/Swiss-Prot: SRCH_HUMAN, P23327
Function: May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac
muscle

Gene Wiki entry for HRC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HRC gene promoter:
         RFX1   AML1a   MAZR   p300   Bach2   AP-4   Arnt   AREB6   ZID   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHRC promoter sequence
   Search Chromatin IP Primers for HRC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HRC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3

HRC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HRC gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M049654:  view genomic region     (about GC identifiers)

Start:
49,654,455 bp from pter      End:
49,658,681 bp from pter
Size:
4,227 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SRCH_HUMAN, P23327 (See protein sequence)
Recommended Name: Sarcoplasmic reticulum histidine-rich calcium-binding protein precursor  
Size: 699 amino acids; 80244 Da
Secondary accessions: Q504Y6

Explore the universe of human proteins at neXtProt for HRC: NX_P23327

Explore proteomics data for HRC at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HRC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002143.1  
    ENSEMBL proteins: 
     ENSP00000252825   ENSP00000469659   ENSP00000470288  

    HRC Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for HRC

     
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    LSBio Antibodies in human, mouse, rat for HRC

    HRC Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
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    Cloud-Clone Corp. CLIAs for HRC
    Search eBioscience for ELISAs for HRC 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR019552 Hist_rich_Ca-bd
     IPR015666 His-rich_Ca-bd

    Graphical View of Domain Structure for InterPro Entry P23327

    ProtoNet protein and cluster: P23327

    UniProtKB/Swiss-Prot: SRCH_HUMAN, P23327
    Similarity: Belongs to the HRC family


    Find genes that share domains with HRC           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRCH_HUMAN, P23327
    Function: May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac
    muscle

         Genatlas biochemistry entry for HRC:
    histidine-rich calcium binding protein (sarcoplasmic reticulum,luminal)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding TAS2037293
    GO:0005515protein binding IPI17526652
    GO:0044325ion channel binding IPI17526652
    GO:0051117ATPase binding IPI17526652
         
    Find genes that share ontologies with HRC           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hrc):
     adipose tissue  behavior/neurological  cardiovascular system  growth/size/body  homeostasis/metabolism 
     muscle 

    Find genes that share phenotypes with HRC           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Hrctm1Blk for HRC

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HRC
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HRC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HRC
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HRC

    miRNA
    Products:
        
    miRTarBase miRNAs that target HRC:
    hsa-mir-335-5p (MIRT017575)

    Block miRNA regulation of human, mouse, rat HRC using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate HRC:
    hsa-miR-539
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HRC

    Gene Editing
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HRC

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SRCH_HUMAN, P23327: Sarcoplasmic reticulum lumen
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular2
    cytosol1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0033017sarcoplasmic reticulum membrane IEA--
    GO:0033018sarcoplasmic reticulum lumen TAS11504710

    Find genes that share ontologies with HRC           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HRC
    Interactions:

        GeneGlobe Interaction Network for HRC

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for HRC (P233273 ENSP000002528254) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRDNQ130613I2D: score=2 
    KNCNENSP000003796074STRING: ENSP00000379607
    --ENSP000003812274STRING: ENSP00000381227
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006936muscle contraction TAS2037293
    GO:0008016regulation of heart contraction ----
    GO:0010881regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion TAS17526652
    GO:0055074calcium ion homeostasis IEA--

    Find genes that share ontologies with HRC           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HRC (SRCH)

    1 HMDB Compound for HRC    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    2 Novoseek inferred chemical compound relationships for HRC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ryanodine 63.9 3 15191886 (2), 17526652 (1)
    calcium 39 17 1527222 (3), 10512736 (2), 10531621 (1), 10398759 (1) (see all 9)



    Find genes that share compounds with HRC           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HRC gene: 
    NM_002152.2  

    Unigene Cluster for HRC:

    Histidine rich calcium binding protein
    Hs.436885  [show with all ESTs]
    Unigene Representative Sequence: NM_002152
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000252825(uc002pmv.3) ENST00000598858 ENST00000595625 ENST00000595167

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HRC using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate HRC:
    hsa-miR-539
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HRC
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    GenScript: all cDNA clones in your preferred vector: HRC (NM_002152)
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for HRC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HRC
      QuantiTect SYBR Green Assays in human, mouse, rat HRC
      QuantiFast Probe-based Assays in human, mouse, rat HRC

    Additional mRNA sequence: 

    AK300706.1 BC069795.1 BC069802.1 BC094691.1 BC112355.1 M60052.1 

    3 DOTS entries:

    DT.306252  DT.101975522  DT.70102010 

    Selected AceView cDNA sequences (see all 29):

    AJ709091 M60052 BX095911 BC069795 AJ708095 BC069802 NM_002152 CF552507 
    AW451524 BU734330 BX503233 AI769340 BX501657 BX503203 F26849 BX501760 
    BX501653 F29472 CF552455 AI803012 AW611587 BM716386 BF475747 CD103822 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for HRC    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6
    SP1:                                -               
    SP2:                                                


    ECgene alternative splicing isoforms for HRC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HRC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HRC Expression
    About this image


    HRC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Bone (Muscoskeletal System)
             Chondrocytes Zeugopod Epiphyseal End
     
     Cartilage (Muscoskeletal System)
             Chondrocytes Zeugopod Epiphyseal End
     
     Heart (Cardiovascular System)
     
     Skeletal Muscle (Muscoskeletal System)
    HRC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HRC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436885
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HRC gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hrc5 histidine rich calcium binding protein   --   7 (29.26 cM) 45335290 
    zebrafish
    (Danio rerio)
    Actinopterygii HRC6
    histidine rich calcium binding protein
    30(a)
    1 ↔ 1
    12(5058011-5069419) ENSDARG00000045947


    ENSEMBL Gene Tree for HRC (if available)
    TreeFam Gene Tree for HRC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HRC (see all 187)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1173336421,2
    C,F--49654852(+) TGCACG/AAGCAA 1 -- int11Minor allele frequency- A:0.03NA 120
    rs1811700751,2
    --49654904(+) GCTCCA/GCCTCC 1 -- int10--------
    rs748103501,2
    C--49654944(+) CCCTTA/CTACCG 1 -- int10--------
    rs1114583051,2
    C--49655091(+) CTCCAG/CCTGGT 1 -- int11Minor allele frequency- C:0.50CSA 2
    rs1135678931,2
    C--49655106(+) CTCGAG/TCCAGG 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs14235201,2
    C,F,A,H--49655174(+) AGCCTT/ACCGGG 1 -- int117Minor allele frequency- A:0.40MN NS EA WA NA CSA 980
    rs3698804371,2
    C--49655208(+) TCACCA/GCGCTG 1 -- int10--------
    rs2006266391,2
    C--49655258(+) ATGCTC/TACCTG 1 -- int10--------
    rs1116210461,2
    C,F--49655273(+) GCAGAC/TCGTTT 2 I V mis12Minor allele frequency- T:0.01CSA NA 4208
    rs2001121411,2
    --49655299(+) AGAGAG/TAGCAG 2 Y S mis10--------

    HapMap Linkage Disequilibrium report for HRC (49654455 - 49658681 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for HRC:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3971n71CNV Loss21882294
    nsv912255CNV Loss21882294
    nsv912258CNV Loss21882294
    nsv470149CNV Loss18288195
    nsv833859CNV Loss17160897
    dgv3970n71CNV Loss21882294
    nsv524235CNV Gain19592680
    nsv9739CNV Gain+Loss18304495

    Human Gene Mutation Database (HGMD): HRC
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HRC
    DNA2.0 Custom Variant and Variant Library Synthesis for HRC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142705    OMIM disorders: --

    1 disease for HRC:    
    About MalaCards
    mixed glioma

    1 disease from the University of Copenhagen DISEASES database for HRC:
    Mixed glioma

    Find genes that share disorders with HRC           About GenesLikeMe

    1 Novoseek inferred disease relationship for HRC gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    niddm 22.9 3 7913686 (2)

    Genetic Association Database (GAD): HRC
    Human Genome Epidemiology (HuGE) Navigator: HRC (1 document)

    Export disorders for HRC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HRC gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with HRC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA and genomic cloning of HRC, a human sarcoplasmic reticulum protein, and localization of the gene to human chromosome 19 and mouse chromosome 7. (PubMed id 2037293)1, 2, 3, 9 Hofmann S.L.... Francke U. (Genomics 1991)
    2. The Ser96Ala variant in histidine-rich calcium-binding protein is associated with life-threatening ventricular arrhythmias in idiopathic dilated cardiomyopathy. (PubMed id 18617481)1, 4, 9 Arvanitis D.A....Kranias E.G. (Eur. Heart J. 2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Interaction of HRC (histidine-rich Ca(2+)-binding protein) and triadin in the lumen of sarcoplasmic reticulum. (PubMed id 11504710)1, 9 Lee H.G....Park W.J. (J. Biol. Chem. 2001)
    5. Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase. (PubMed id 17526652)1, 9 Arvanitis D.A....Kranias E.G. (Am. J. Physiol. Heart Circ. Physiol. 2007)
    6. Regulation of myocardial function by histidine-rich, calcium-binding protein. (PubMed id 15191886)1, 9 Fan G.C....Kranias E.G. (Am. J. Physiol. Heart Circ. Physiol. 2004)
    7. Abnormal calcium cycling and cardiac arrhythmias associated with the human Ser96Ala genetic variant of histidine-rich calcium-binding protein. (PubMed id 24125847)1 Singh V.P....Kranias E.G. (J Am Heart Assoc 2013)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    9. HRC is a direct transcriptional target of MEF2 during cardiac, skeletal, and arterial smooth muscle development in vivo. (PubMed id 15082771)1 Anderson J.P....Black B.L. (Mol. Cell. Biol. 2004)
    10. Increased Ca2+ storage capacity in the sarcoplasmic reticulum by overexpression of HRC (histidine-rich Ca2+ binding protein). (PubMed id 12480542)1 Kim E....Park W.J. (Biochem. Biophys. Res. Commun. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3270 HGNC: 5178 AceView: HRC Ensembl:ENSG00000130528 euGenes: HUgn3270
    ECgene: HRC H-InvDB: HRC

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HRC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HRC gene:
    Search GeneIP for patents involving HRC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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