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Aliases for HRC Gene

Aliases for HRC Gene

  • Histidine Rich Calcium Binding Protein 2 3 5
  • Histidine-Rich Calcium-Binding Protein 2
  • HCP 4

External Ids for HRC Gene

Previous GeneCards Identifiers for HRC Gene

  • GC19M050312
  • GC19M050022
  • GC19M054330
  • GC19M054346
  • GC19M049654
  • GC19M046030

Summaries for HRC Gene

Entrez Gene Summary for HRC Gene

  • This gene encodes a luminal sarcoplasmic reticulum protein identified by its ability to bind low-density lipoprotein with high affinity. The protein interacts with the cytoplasmic domain of triadin, the main transmembrane protein of the junctional sarcoplasmic reticulum (SR) of skeletal muscle. The protein functions in the regulation of releasable calcium into the SR. [provided by RefSeq, Sep 2008]

GeneCards Summary for HRC Gene

HRC (Histidine Rich Calcium Binding Protein) is a Protein Coding gene. Diseases associated with HRC include Mixed Glioma. GO annotations related to this gene include calcium ion binding and ATPase binding.

UniProtKB/Swiss-Prot for HRC Gene

  • May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle.

Gene Wiki entry for HRC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HRC Gene

Genomics for HRC Gene

Regulatory Elements for HRC Gene

Enhancers for HRC Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HRC on UCSC Golden Path with GeneCards custom track

Promoters for HRC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HRC on UCSC Golden Path with GeneCards custom track

Genomic Location for HRC Gene

49,151,198 bp from pter
49,155,429 bp from pter
4,232 bases
Minus strand

Genomic View for HRC Gene

Genes around HRC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HRC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HRC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HRC Gene

Proteins for HRC Gene

  • Protein details for HRC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sarcoplasmic reticulum histidine-rich calcium-binding protein
    Protein Accession:
    Secondary Accessions:
    • Q504Y6

    Protein attributes for HRC Gene

    699 amino acids
    Molecular mass:
    80244 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HRC Gene

Proteomics data for HRC Gene at MOPED

Post-translational modifications for HRC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HRC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HRC Gene

Domains & Families for HRC Gene

Protein Domains for HRC Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the HRC family.
  • Belongs to the HRC family.
genes like me logo Genes that share domains with HRC: view

No data available for Gene Families for HRC Gene

Function for HRC Gene

Molecular function for HRC Gene

GENATLAS Biochemistry:
histidine-rich calcium binding protein (sarcoplasmic reticulum,luminal)
UniProtKB/Swiss-Prot Function:
May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle.
genes like me logo Genes that share phenotypes with HRC: view

Animal Model Products

miRNA for HRC Gene

miRTarBase miRNAs that target HRC

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HRC Gene

Localization for HRC Gene

Subcellular locations from UniProtKB/Swiss-Prot for HRC Gene

Sarcoplasmic reticulum lumen.

Subcellular locations from

Jensen Localization Image for HRC Gene COMPARTMENTS Subcellular localization image for HRC gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 4
extracellular 2
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for HRC Gene

Pathways & Interactions for HRC Gene

SuperPathways for HRC Gene

No Data Available

Interacting Proteins for HRC Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: P23327-SRCH_HUMAN ENSP00000252825 for HRC Gene via I2D UniProtKB STRING

Gene Ontology (GO) - Biological Process for HRC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction TAS 2037293
GO:0008016 regulation of heart contraction IEA --
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IGI 24125847
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion TAS 17526652
GO:0051481 negative regulation of cytosolic calcium ion concentration IBA --
genes like me logo Genes that share ontologies with HRC: view

No data available for Pathways by source and SIGNOR curated interactions for HRC Gene

Drugs & Compounds for HRC Gene

(2) Drugs for HRC Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with HRC: view

Transcripts for HRC Gene

Unigene Clusters for HRC Gene

Histidine rich calcium binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HRC Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1: -

Relevant External Links for HRC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HRC Gene

mRNA expression in normal human tissues for HRC Gene

mRNA differential expression in normal tissues according to GTEx for HRC Gene

This gene is overexpressed in Heart - Left Ventricle (x24.9), Heart - Atrial Appendage (x12.0), and Muscle - Skeletal (x10.9).

Protein differential expression in normal tissues from HIPED for HRC Gene

This gene is overexpressed in Heart (45.5) and Fetal heart (14.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for HRC Gene

SOURCE GeneReport for Unigene cluster for HRC Gene Hs.436885

genes like me logo Genes that share expression patterns with HRC: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for HRC Gene

Orthologs for HRC Gene

This gene was present in the common ancestor of chordates.

Orthologs for HRC Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HRC 35
  • 79.14 (n)
  • 68.39 (a)
HRC 36
  • 55 (a)
(Pan troglodytes)
Mammalia HRC 35
  • 96.59 (n)
  • 94.07 (a)
HRC 36
  • 92 (a)
(Canis familiaris)
Mammalia HRC 36
  • 58 (a)
(Mus musculus)
Mammalia Hrc 36
  • 48 (a)
(Ornithorhynchus anatinus)
Mammalia HRC 36
  • 41 (a)
(Danio rerio)
Actinopterygii HRC 36
  • 30 (a)
Species with no ortholog for HRC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HRC Gene

Gene Tree for HRC (if available)
Gene Tree for HRC (if available)

Paralogs for HRC Gene

No data available for Paralogs for HRC Gene

Variants for HRC Gene

Sequence variations from dbSNP and Humsavar for HRC Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs3745297 - 49,154,952(+) CTTGG(A/C)GACAT nc-transcript-variant, reference, missense
rs3745298 - 49,155,110(+) CAGTG(C/T)TGTTG nc-transcript-variant, reference, missense
rs7409255 -- 49,154,659(+) tcctc(C/T)tcTCC nc-transcript-variant, reference, synonymous-codon
rs12977714 -- 49,152,726(+) CACCA(C/T)GCCCG intron-variant
rs66501117 -- 49,154,454(+) GGAGA(-/CAT)CATCA cds-indel

Structural Variations from Database of Genomic Variants (DGV) for HRC Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
dgv3970n71 CNV Loss 21882294
nsv833859 CNV Loss 17160897
nsv912255 CNV Loss 21882294
nsv912258 CNV Loss 21882294
dgv3971n71 CNV Loss 21882294
nsv470149 CNV Loss 18288195
nsv524235 CNV Gain 19592680

Variation tolerance for HRC Gene

Residual Variation Intolerance Score: 92.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.86; 91.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HRC Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HRC Gene

Disorders for HRC Gene

MalaCards: The human disease database

(1) MalaCards diseases for HRC Gene - From: DISEASES

Disorder Aliases PubMed IDs
mixed glioma
  • mixed gliomas
- elite association - COSMIC cancer census association via MalaCards
Search HRC in MalaCards View complete list of genes associated with diseases

Relevant External Links for HRC

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HRC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HRC Gene

Publications for HRC Gene

  1. cDNA and genomic cloning of HRC, a human sarcoplasmic reticulum protein, and localization of the gene to human chromosome 19 and mouse chromosome 7. (PMID: 2037293) Hofmann S.L. … Francke U. (Genomics 1991) 2 3 4 23 67
  2. The Ser96Ala variant in histidine-rich calcium-binding protein is associated with life-threatening ventricular arrhythmias in idiopathic dilated cardiomyopathy. (PMID: 18617481) Arvanitis D.A. … Kranias E.G. (Eur. Heart J. 2008) 3 23
  3. Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase. (PMID: 17526652) Arvanitis D.A. … Kranias E.G. (Am. J. Physiol. Heart Circ. Physiol. 2007) 3 23
  4. Regulation of myocardial function by histidine-rich, calcium-binding protein. (PMID: 15191886) Fan G.C. … Kranias E.G. (Am. J. Physiol. Heart Circ. Physiol. 2004) 3 23
  5. Interaction of HRC (histidine-rich Ca(2+)-binding protein) and triadin in the lumen of sarcoplasmic reticulum. (PMID: 11504710) Lee H.G. … Park W.J. (J. Biol. Chem. 2001) 3 23

Products for HRC Gene

Sources for HRC Gene