HRASLS5 Gene
protein-coding GIFtS : 46
GCID: GC11 M063230
HRAS-like suppressor family, member 5
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Aliasesfor HRASLS5 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases HRAS-Like Suppressor Family, Member 5 1 2 RLP12 HRLP51 2 3 Ca(2+)-Independent N-Acyltransferase2 HRSL52 3 Calcium-Independent Phosphatidylethanolamine N-Acyltransferase2 H-Rev107-Like Protein 52 3 Lecithin-Retinol Acyltransferase (LRAT)-Like Protein-12 HRAS-Like Suppressor 52 3 EC 2.3.1.-3 INAT1
Export aliases for HRASLS5 gene to outside databases Previous GC identifers: GC11M062988 GC11M059557
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Summariesfor HRASLS5 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: HRSL5_HUMAN, Q96KN8 Function : catalyzes N-acylation of phosphatidylethanolamine (PE) to generate N-Acylphosphatidylethanolamine (NAPE) aprecursor of bioactive N-acylethanolamines, including the endocannabinoid anandamide
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Genomic Viewsfor HRASLS5 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000011.9 NC_018922.1 NT_167190.1 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the HRASLS5 gene promoter: CREB RFX1 PPAR-gamma1 deltaCREB PPAR-gamma2 C/EBPalpha Other transcription factors Search SABiosciences Chromatin IP Primers for HRASLS5 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HRASLS5
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11q13.2 Ensembl cytogenetic band: 11q12.3 HGNC cytogenetic band: 11q13.2 HRASLS5 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11M063230: view genomic region
(about GC identifiers )
Start:
63,228,876 bp from pter
End:
63,258,680 bp from pter
Size:
29,805 bases
Orientation:
minus strand
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Proteinsfor HRASLS5 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: HRSL5_HUMAN, Q96KN8 (See
protein sequence )Recommended Name: Ca(2+)-independent N-acyltransferase Size : 279 amino acids; 30312 Da
Secondary accessions : B7X6T1 F5GZ87 F5H4Y9Alternative splicing : 3 isoforms : Q96KN8-1 Q96KN8-2 Q96KN8-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for HRASLS5: NX_Q96KN8 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q96KN8 HRASLS5 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (3 alternative transcripts):
NP_001140200.1 NP_001140201.1 NP_473449.1 ENSEMBL proteins: ENSP00000444776 ENSP00000444809 ENSP00000443873 ENSP00000301790 ENSP00000378113 ENSP00000446016 Human Recombinant Protein Products for HRASLS5: HRASLS5 Antibody Products: Assay Products for HRASLS5:
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Protein
Domains / Familiesfor HRASLS5 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
HRASLS5 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q96KN8 ProtoNet protein and cluster: Q96KN8
1 Blocks protein family : IPB007053 NC UniProtKB/Swiss-Prot: HRSL5_HUMAN, Q96KN8 Similarity : Belongs to the H-rev107 family
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Functionfor HRASLS5 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: HRSL5_HUMAN, Q96KN8 Function : catalyzes N-acylation of phosphatidylethanolamine (PE) to generate N-Acylphosphatidylethanolamine (NAPE) aprecursor of bioactive N-acylethanolamines, including the endocannabinoid anandamide Enzyme Number (IUBMB): EC 2.3.1.- 1
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0016746 transferase activity, transferring acyl groups
IEA --
HRASLS5 for ontologies About GeneDecksing Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for HRASLS5 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for HRASLS5 (see all 4 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): HRASLS5 (NM_054108 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HRASLS5 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat HRASLS5
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRASLS5
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Pathways & Interactionsfor HRASLS5 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Acyl chain remodelling of PE
Pathway sources See GeneCards unified pathways Show all pathways 1 EMD Millipore Pathway for HRASLS5 1 GeneGo (Thomson Reuters) Pathway for HRASLS5
HRASLS5 for pathways About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HRASLS5
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Drugs & Compoundsfor HRASLS5 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for HRASLS5 Search CenterWatch for drugs/clinical trials and news about HRASLS5 / HRSL5
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Transcriptsfor HRASLS5 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for HRASLS5 gene (3 alternative transcripts): NM_001146728.1 NM_001146729.1 NM_054108.3 Unigene Cluster for HRASLS5:
HRAS-like suppressor family, member 5 Hs.410316 [show with all ESTs ] Unigene Representative Sequence: NM_054108 6 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000536887 ENST00000540857 (uc001nwy.2 uc001nwz.2 uc010rmq.1 uc009yos.2 )ENST00000539221 ENST00000301790 ENST00000394615 ENST00000538712 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for HRASLS5 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for HRASLS5 (see all 4 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): HRASLS5 (NM_054108 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HRASLS5 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat HRASLS5
Additional cDNA sequence: AB298804.1 AJ416558.1 AK055392.1 AK302312.1 BC034222.1
7 DOTS entries : DT.112647 DT.95262406
DT.108116 DT.100704859 DT.120679431 DT.120679435 DT.120679438 24/73 AceView cDNA sequences (see all 73 ):
AW664905 AA421081 Z44235 AA460513 AI341442 AK055392 BF478187 BC034222 AA781188 BX503524 BF592127 BM696761 AA758752 BX477886 AW664966 F03385 AW268475 BI831220 AI970490 AI797389 AA860910 CD644416 AA219332 BE326945 GeneLoc Exon Structure 5/7 Alternative Splicing Database (ASD) splice patterns (SP) for HRASLS5 (see all 7 ) About this scheme ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c · 7d SP1 :         -         -             -           SP2 :         -   -       -                       SP3 :         -   -   -   -   -             -           SP4 :         -   -     -   -   -           -           SP5 :         -   -                            
ECgene alternative splicing isoforms for HRASLS5
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Expression for HRASLS5 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section HRASLS5 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GAGTGGAGAGAbout this image HRASLS5 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Testis Seminiferous Tubules Mature Sertoli Cells Testis Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell Name Category Definitive endoderm-like cells (A scalable, suspensi... )
See HRASLS5 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for HRASLS5 SOURCE GeneReport for Unigene cluster: Hs.410316 UniProtKB/Swiss-Prot: HRSL5_HUMAN, Q96KN8 Tissue specificity : Highest expression level in testis and pancreas SABiosciences Custom PCR Arrays for HRASLS5 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for HRASLS5Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat HRASLS5 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat HRASLS5 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat HRASLS5 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRASLS5
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Orthologsfor HRASLS5 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for HRASLS5 gene from 1/7 species (see all 7 ) About this table
ENSEMBL Gene Tree for HRASLS5 (if available)TreeFam Gene Tree for HRASLS5 (if available)
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Paralogsfor HRASLS5 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for HRASLS5 gene PLA2G16 2 HRASLS 2 RARRES3 2 HRASLS2 2 4 SIMAP similar genes for HRASLS5 using alignment to 5 protein entries: HRSL5_HUMAN (see all proteins ):HRASLS RARRES3 PLA2G16 HRASLS2
HRASLS5 for paralogs About GeneDecksing
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Genomic Variantsfor HRASLS5 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 11 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for HRASLS5 (63228876 - 63258680 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for HRASLS5: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing HRASLS5
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Disorders
/ Diseasesfor HRASLS5 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
HRASLS5 for disorders About MalaCards
HRASLS5 for disorders About GeneDecksing
OMIM gene information: 611474
OMIM disorders : --Export disorders for HRASLS5 gene to outside databases
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Publicationsfor HRASLS5 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for HRASLS5 gene integrated from 9 sources : (articles sorted by number of sources associating them with HRASLS5) Utopia : connect your pdf to the dynamic world of online information
cDNA cloning and characterization of human and mouse Ca(2+)- independent phosphatidylethanolamine N-acyltransferases. (PubMed id 19000777) 1 , 2 Jin X.-H.... Ueda N. (2009) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 OlA!h J....OvA!di J. (2011) Discovery and characterization of a Ca2+-independent phosphatidylethanolamine N-acyltransferase generating the anandamide precursor and its congeners. (PubMed id 17158102) 1 Jin X.H....Ueda N. (2007) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 Lamesch P.... Vidal M. (2007) Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811) 2 Taylor T.D....Sakaki Y. (2006) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for HRASLS5 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing HRASLS5 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing HRASLS5 gene
(According to HUGE )
About This Section --
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Specialized Databases showing HRASLS5 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for HRASLS5 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for HRASLS5 gene: Search GeneIP for patents involving HRASLS5 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor HRASLS5 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for HRASLS5 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for HRASLS5 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for HRASLS5 OriGene Protein Over-expression Lysate for HRASLS5 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for HRASLS5 OriGene 3'-UTR Clone for HRASLS5 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for HRASLS5 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for HRASLS5 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for HRASLS5 OriGene Custom Protein Services for HRASLS5 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HRASLS5 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing HRASLS5 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HRASLS5 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat HRASLS5 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat HRASLS5 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat HRASLS5
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HRASLS5 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRASLS5
Search ThermoFisher Antibodies for HRASLS5
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat HRASLS5
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Aliases for HRASLS5
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Expression for HRASLS5
Function for HRASLS5
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