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Aliases for HRASLS5 Gene

Aliases for HRASLS5 Gene

  • HRAS-Like Suppressor Family, Member 5 2 3
  • H-Rev107-Like Protein 5 3 4
  • HRAS-Like Suppressor 5 3 4
  • HRLP5 3 4
  • HRSL5 3 4
  • INAT 3 4
  • Calcium-Independent Phosphatidylethanolamine N-Acyltransferase 3
  • Lecithin-Retinol Acyltransferase (LRAT)-Like Protein-1 3
  • Ca(2+)-Independent N-Acyltransferase 3
  • EC 2.3.1.- 4
  • RLP1 3

External Ids for HRASLS5 Gene

Summaries for HRASLS5 Gene

GeneCards Summary for HRASLS5 Gene

HRASLS5 (HRAS-Like Suppressor Family, Member 5) is a Protein Coding gene. Among its related pathways are phospholipases. GO annotations related to this gene include transferase activity, transferring acyl groups. An important paralog of this gene is RARRES3.

UniProtKB/Swiss-Prot for HRASLS5 Gene

  • catalyzes N-acylation of phosphatidylethanolamine (PE) to generate N-Acylphosphatidylethanolamine (NAPE) a precursor of bioactive N-acylethanolamines, including the endocannabinoid anandamide.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HRASLS5 Gene

Genomics for HRASLS5 Gene

Genomic Location for HRASLS5 Gene

Start:
63,461,404 bp from pter
End:
63,491,208 bp from pter
Size:
29,805 bases
Orientation:
Minus strand

Genomic View for HRASLS5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HRASLS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HRASLS5 Gene

Regulatory Elements for HRASLS5 Gene

Proteins for HRASLS5 Gene

  • Protein details for HRASLS5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KN8-HRSL5_HUMAN
    Recommended name:
    Ca(2+)-independent N-acyltransferase
    Protein Accession:
    Q96KN8
    Secondary Accessions:
    • B7X6T1
    • F5GZ87
    • F5H4Y9

    Protein attributes for HRASLS5 Gene

    Size:
    279 amino acids
    Molecular mass:
    30312 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HRASLS5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HRASLS5 Gene

Proteomics data for HRASLS5 Gene at MOPED

Post-translational modifications for HRASLS5 Gene

No Post-translational modifications

Other Protein References for HRASLS5 Gene

No data available for DME Specific Peptides for HRASLS5 Gene

Domains for HRASLS5 Gene

Protein Domains for HRASLS5 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

HRSL5_HUMAN
Family:
  • Belongs to the H-rev107 family.:
    • Q96KN8
genes like me logo Genes that share domains with HRASLS5: view

No data available for Gene Families for HRASLS5 Gene

Function for HRASLS5 Gene

Molecular function for HRASLS5 Gene

UniProtKB/Swiss-Prot Function: catalyzes N-acylation of phosphatidylethanolamine (PE) to generate N-Acylphosphatidylethanolamine (NAPE) a precursor of bioactive N-acylethanolamines, including the endocannabinoid anandamide.

Enzyme Numbers (IUBMB) for HRASLS5 Gene

Gene Ontology (GO) - Molecular Function for HRASLS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with HRASLS5: view

miRNA for HRASLS5 Gene

miRTarBase miRNAs that target HRASLS5

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HRASLS5 Gene

Localization for HRASLS5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HRASLS5 Gene COMPARTMENTS Subcellular localization image for HRASLS5 gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for HRASLS5 Gene

Pathways for HRASLS5 Gene

SuperPathways for HRASLS5 Gene

Superpath Contained pathways
1 phospholipases
genes like me logo Genes that share pathways with HRASLS5: view

Pathways by source for HRASLS5 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for HRASLS5 Gene

Interacting Proteins for HRASLS5 Gene

Gene Ontology (GO) - Biological Process for HRASLS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with HRASLS5: view

Transcripts for HRASLS5 Gene

Unigene Clusters for HRASLS5 Gene

HRAS-like suppressor family, member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HRASLS5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c · 7d
SP1: - - -
SP2: - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - -
SP6: -
SP7:

Relevant External Links for HRASLS5 Gene

GeneLoc Exon Structure for
HRASLS5
ECgene alternative splicing isoforms for
HRASLS5

Expression for HRASLS5 Gene

mRNA expression in normal human tissues for HRASLS5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HRASLS5 Gene

This gene is overexpressed in Testis (13.0), Adipose - Visceral (Omentum) (5.0), and Adipose - Subcutaneous (4.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for HRASLS5 Gene

SOURCE GeneReport for Unigene cluster for HRASLS5 Gene Hs.410316

mRNA Expression by UniProt/SwissProt for HRASLS5 Gene

Q96KN8-HRSL5_HUMAN
Tissue specificity: Highest expression level in testis and pancreas
genes like me logo Genes that share expressions with HRASLS5: view

Orthologs for HRASLS5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HRASLS5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HRASLS5 36
  • 98.92 (n)
  • 97.85 (a)
HRASLS5 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HRASLS5 36
  • 86.21 (n)
  • 88.89 (a)
HRASLS5 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HRASLS5 36
  • 84.27 (n)
  • 79.84 (a)
HRASLS5 37
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hrasls5 36
  • 76.99 (n)
  • 72.76 (a)
Hrasls5 16
Hrasls5 37
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hrasls5 36
  • 75.42 (n)
  • 72.59 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 32 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CR383676.3 37
  • 40 (a)
ManyToMany
CU138503.3 37
  • 36 (a)
ManyToMany
zgc:154040 37
  • 34 (a)
ManyToMany
zgc:92249 37
  • 36 (a)
ManyToMany
Species with no ortholog for HRASLS5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HRASLS5 Gene

ENSEMBL:
Gene Tree for HRASLS5 (if available)
TreeFam:
Gene Tree for HRASLS5 (if available)

Paralogs for HRASLS5 Gene

Paralogs for HRASLS5 Gene

Selected SIMAP similar genes for HRASLS5 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with HRASLS5: view

Variants for HRASLS5 Gene

Sequence variations from dbSNP and Humsavar for HRASLS5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1305 -- 63,461,589(+) AACCA(C/T)TACAG utr-variant-3-prime, nc-transcript-variant
rs940611 - 63,488,969(+) TACAG(C/G)CTTCT missense, reference, nc-transcript-variant
rs940612 -- 63,489,922(+) AATCT(C/G)GCAAA intron-variant
rs2154751 -- 63,464,600(+) GCAGT(A/G)AGCCG intron-variant
rs2264666 -- 63,487,780(+) tccat(A/G)caatg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HRASLS5 Gene

Variant ID Type Subtype PubMed ID
nsv468588 CNV Loss 19166990
nsv509417 CNV Insertion 20534489

Relevant External Links for HRASLS5 Gene

HapMap Linkage Disequilibrium report
HRASLS5

Disorders for HRASLS5 Gene

No disorders were found for HRASLS5 Gene.

No data available for UniProtKB/Swiss-Prot for HRASLS5 Gene

Publications for HRASLS5 Gene

  1. cDNA cloning and characterization of human and mouse Ca(2+)- independent phosphatidylethanolamine N-acyltransferases. (PMID: 19000777) Jin X.-H. … Ueda N. (Biochim. Biophys. Acta 2009) 3 4
  2. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for HRASLS5 Gene

Sources for HRASLS5 Gene

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