HRASLS2 Gene
protein-coding GIFtS: 43
GCID: GC11M063320
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|
HRAS-like suppressor 2
| |
Aliases
for HRASLS2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| HRAS-Like Suppressor 21 2 | | FLJ205561 | | PLA1/2-22 | | EC 2.3.1.-3 | | EC 3.1.1.-3 |
Export aliases for HRASLS2 gene to outside databasesPrevious GC identifers: GC11M065832 GC11M064896 GC11M063571 GC11M063095 GC11M063076 GC11M059649 |
Summaries
for HRASLS2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: HRSL2_HUMAN, Q9NWW9Function: Exhibits PLA1/2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in variousphosphotidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher thanPLA2 activity. Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor. Alsocatalyzes O-acylation converting lyso-PC into PC
|
Genomic Views
for HRASLS2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HRASLS2 gene promoter:
JunB GCNF CUTL1 RORalpha1 FAC1 POU2F1 JunD GCNF-1 POU2F1a GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for HRASLS2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HRASLS2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q12.3 Ensembl cytogenetic band: 11q12.3 HGNC cytogenetic band: 11q12.2HRASLS2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M063320: view genomic region
(about GC identifiers)
Start:
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63,320,242 bp from pter |
End:
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63,330,855 bp from pter |
Size:
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10,614 bases |
Orientation:
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minus strand |
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Proteins
for HRASLS2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HRSL2_HUMAN, Q9NWW9 (See
protein sequence)Recommended Name: HRAS-like suppressor 2 Size: 162 amino acids; 17394 Da
Subcellular location: Cytoplasm. Membrane; Single-pass membrane protein. Note=Exhibits a granular pattern in thecytoplasm with preferential perinuclear localization
1 PDB 3D structure from  and Proteopedia  for HRASLS2:4DPZ (3D)
Secondary accessions: B9A7L8Explore the universe of human proteins at neXtProt for HRASLS2: NX_Q9NWW9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NWW9
HRASLS2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060348.1
ENSEMBL proteins: ENSP00000255695
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
HRASLS2 for ontologies About GeneDecksing
HRASLS2 Antibody Products:
Assay Products for HRASLS2: |
Protein
Domains /
Families
for HRASLS2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HRASLS2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NWW9ProtoNet protein and cluster: Q9NWW9 1 Blocks protein family: IPB007053 NC
UniProtKB/Swiss-Prot: HRSL2_HUMAN, Q9NWW9Similarity: Belongs to the H-rev107 family |
Function
for HRASLS2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: HRSL2_HUMAN, Q9NWW9Function: Exhibits PLA1/2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in variousphosphotidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher thanPLA2 activity. Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor. Alsocatalyzes O-acylation converting lyso-PC into PCCatalytic activity: Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylateCatalytic activity: Phosphatidylcholine + H(2)O = 2-acylglycerophosphocholine + a carboxylateCatalytic activity: Phosphatidylcholine + phosphoethanolamine = 1-acylglycerophosphocholine +N-palmitoyl-phosphoethanolamineBiophysicochemical properties: Kinetic parameters: KM=300 uM for dipalmitoyl-PC; Vmax=670 nmol/min/mg enzyme withdipalmitoyl-PC as substrate; Vmax=122 nmol/min/mg enzyme with dipalmitoyl-PE as substrate; Vmax=103 nmol/min/mg enzymeusing dipalmitoyl-PC as an acyl donor and PE as an acyl acceptor; pH dependence: Optimum pH is 8;Enzyme Numbers (IUBMB): EC 3.1.1.-1 EC 2.3.1.-1
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HRASLS2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for HRASLS2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HRASLS2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016746 | transferase activity, transferring acyl groups |
IEA | -- | | GO:0016787 | hydrolase activity |
IEA | -- |
HRASLS2 for ontologies About GeneDecksing
6 GenomeRNAi human phenotypes for HRASLS2:
|
Pathways & Interactions
for HRASLS2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HRASLS2
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016042 | lipid catabolic process |
IEA | -- |
HRASLS2 for ontologies About GeneDecksing
|
Drugs & Compounds
for HRASLS2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HRASLS2
Search CenterWatch for drugs/clinical trials and news about HRASLS2 / HRSL2
|
Transcripts
for HRASLS2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HRASLS2 gene: NM_017878.1 Unigene Cluster for HRASLS2: HRAS-like suppressor 2 Hs.272805 [show with all ESTs]Unigene Representative Sequence: AK0250291 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000255695(uc001nxg.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HRASLS2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HRASLS2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HRASLS2 (NM_017878) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HRASLS2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HRASLS2 |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HRASLS2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HRASLS2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HRASLS2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HRASLS2 |
Additional cDNA sequence: AB453251.1 AK000563.1 AK025029.1 2 DOTS entries: DT.40246613 DT.92417502 14 AceView cDNA sequences: BM757638 BM769124 AK000563 NM_017878 AK025029 BU686848 BQ083832 BM819798 BG998109 BM742602 AI695341 C00599 BG202452 BG205041
GeneLoc Exon Structure
|
Expression
for HRASLS2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HRASLS2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATCTTTATT
About this image
See HRASLS2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HRASLS2
SOURCE GeneReport for Unigene cluster: Hs.272805
UniProtKB/Swiss-Prot: HRSL2_HUMAN, Q9NWW9Tissue specificity: Expressed in liver, kidney, small intestine testis and colon (PubMed:19615464). Undetectable intestis, placenta, salivary gland and fetal brain (PubMed:18163183)
SABiosciences Custom PCR Arrays for HRASLS2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HRASLS2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HRASLS2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HRASLS2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HRASLS2 |
Orthologs
for HRASLS2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for HRASLS2 gene from 2/6 species (see all 6) About this table
ENSEMBL Gene Tree for HRASLS2 (if available)
TreeFam Gene Tree for HRASLS2 (if available) |
Paralogs
for HRASLS2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HRASLS2 gene
- PLA2G162 HRASLS2 RARRES32 HRASLS52
4 SIMAP similar genes for HRASLS2 using alignment to 1 protein entry: HRSL2_HUMAN:PLA2G16 HRASLS RARRES3 HRASLS5
HRASLS2 for paralogs About GeneDecksing
|
Genomic Variants
for HRASLS2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HRASLS2 (63320242 - 63330855 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HRASLS2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HRASLS2 |
|
Disorders
/ Diseases
for HRASLS2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 HRASLS2 for disorders About MalaCards
HRASLS2 for disorders About GeneDecksing
OMIM gene information: 613866
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: HRASLS2 (3 documents)
Export disorders for HRASLS2 gene to outside databases
|
Publications
for HRASLS2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HRASLS2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with HRASLS2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and functional characterization of the HRASLS2 gene. (PubMed id 18163183)1, 2, 9 Shyu R.Y....Jiang S.Y. (2008)
- Characterization of the human tumor suppressors TIG3 and HRASLS2 as phospholipid-metabolizing enzymes. (PubMed id 19615464)1, 2, 9 Uyama T.... Ueda N. (2009)
- Structural basis for the acyltransferase activity of lecithin:retinol acyltransferase-like proteins. (PubMed id 22605381)1, 2 Golczak M....Palczewski K. (2012)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
|
External Searches for HRASLS2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HRASLS2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HRASLS2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HRASLS2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HRASLS2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HRASLS2 gene:
Search GeneIP for patents involving HRASLS2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HRASLS2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HRASLS2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HRASLS2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HRASLS2 | | | OriGene Protein Over-expression Lysate for HRASLS2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HRASLS2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HRASLS2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HRASLS2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HRASLS2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HRASLS2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HRASLS2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HRASLS2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HRASLS2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HRASLS2 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HRASLS2 |
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