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Aliases for HRASLS2 Gene

Aliases for HRASLS2 Gene

  • HRAS Like Suppressor 2 2 3 5
  • HRAS-Like Suppressor 2 3
  • EC 2.3.1.- 4
  • EC 3.1.1.- 4
  • PLA1/2-2 3

External Ids for HRASLS2 Gene

Previous GeneCards Identifiers for HRASLS2 Gene

  • GC11M065832
  • GC11M064896
  • GC11M063095
  • GC11M063076
  • GC11M063320
  • GC11M059649

Summaries for HRASLS2 Gene

Entrez Gene Summary for HRASLS2 Gene

  • The protein encoded by this gene has both phospholipase and acyltransferase activities and acts as a tumor suppressor. The encoded protein can hydrolyze dipalmitoylated phosphatidylcholine (PC) to palmitic acid and lyso-PC. In addition, this protein can catalyze the N-acylation of phosphatidylethanolamine and can catalyze the O-acylation of lyso-PC to form PC. [provided by RefSeq, Jul 2016]

GeneCards Summary for HRASLS2 Gene

HRASLS2 (HRAS Like Suppressor 2) is a Protein Coding gene. Diseases associated with HRASLS2 include Poland Syndrome. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. GO annotations related to this gene include hydrolase activity and transferase activity, transferring acyl groups. An important paralog of this gene is PLA2G16.

UniProtKB/Swiss-Prot for HRASLS2 Gene

  • Exhibits PLA1/2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor. Also catalyzes O-acylation converting lyso-PC into PC.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HRASLS2 Gene

Genomics for HRASLS2 Gene

Regulatory Elements for HRASLS2 Gene

Enhancers for HRASLS2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F063528 1.7 FANTOM5 Ensembl ENCODE 11.9 +31.0 31033 10.4 PKNOX1 ATF1 ARNT YY1 ELK1 GATA2 FOS KLF13 JUNB REST TTC9C HRASLS2 ATL3 ENSG00000203520 PLA2G16 TRMT112 ENSG00000256789 AHNAK METTL12 OTUB1
GH11F063478 1 Ensembl ENCODE 10.8 +86.0 85989 0.6 HDGF CTCF ARNT RAD21 YY1 RFX5 TEAD3 ZNF143 SMC3 DNMT1 ENSG00000256789 ENSG00000203520 PLA2G16 HRASLS2 RTN3 LOC100533643 HRASLS5
GH11F063563 1.7 FANTOM5 Ensembl ENCODE 5.6 -0.9 -917 5.8 HDGF PKNOX1 ATF1 ARNT WRNIP1 GATA2 ZNF207 FOS JUNB NCOA1 RARRES3 INTS5 NXF1 TTC9C UBXN1 ENSG00000203520 PLA2G16 METTL12 ENSG00000256789 EEF1G
GH11F063518 0.8 ENCODE 11.2 +46.4 46427 0.9 HDAC1 LEF1 ATF1 PKNOX1 ESRRA TAL1 ETV1 ZNF316 NCOR1 TRIM24 ENSG00000203520 PLA2G16 HRASLS2 ENSG00000256789 ATL3 TMSB4XP5 LGALS12
GH11F063593 0.7 ENCODE 11.6 -28.2 -28195 0.2 CTCF ATF1 ZNF654 PKNOX1 MIER1 MIER2 REST RAD21 ZKSCAN1 ZNF316 HRASLS2 ENSG00000256789 LOC105369335 ENSG00000203520
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HRASLS2 on UCSC Golden Path with GeneCards custom track

Genomic Location for HRASLS2 Gene

Chromosome:
11
Start:
63,552,759 bp from pter
End:
63,565,089 bp from pter
Size:
12,331 bases
Orientation:
Minus strand

Genomic View for HRASLS2 Gene

Genes around HRASLS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HRASLS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HRASLS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HRASLS2 Gene

Proteins for HRASLS2 Gene

  • Protein details for HRASLS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWW9-HRSL2_HUMAN
    Recommended name:
    HRAS-like suppressor 2
    Protein Accession:
    Q9NWW9
    Secondary Accessions:
    • B9A7L8

    Protein attributes for HRASLS2 Gene

    Size:
    162 amino acids
    Molecular mass:
    17394 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HRASLS2 Gene

neXtProt entry for HRASLS2 Gene

Post-translational modifications for HRASLS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HRASLS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HRASLS2 Gene

Domains & Families for HRASLS2 Gene

Gene Families for HRASLS2 Gene

Protein Domains for HRASLS2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for HRASLS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NWW9

UniProtKB/Swiss-Prot:

HRSL2_HUMAN :
  • Belongs to the H-rev107 family.
Family:
  • Belongs to the H-rev107 family.
genes like me logo Genes that share domains with HRASLS2: view

Function for HRASLS2 Gene

Molecular function for HRASLS2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=300 uM for dipalmitoyl-PC {ECO:0000269 PubMed:19615464}; Vmax=670 nmol/min/mg enzyme with dipalmitoyl-PC as substrate {ECO:0000269 PubMed:19615464}; Vmax=122 nmol/min/mg enzyme with dipalmitoyl-PE as substrate {ECO:0000269 PubMed:19615464}; Vmax=103 nmol/min/mg enzyme using dipalmitoyl-PC as an acyl donor and PE as an acyl acceptor {ECO:0000269 PubMed:19615464}; pH dependence: Optimum pH is 8. {ECO:0000269 PubMed:19615464};
UniProtKB/Swiss-Prot CatalyticActivity:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot CatalyticActivity:
Phosphatidylcholine + H(2)O = 2-acylglycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot CatalyticActivity:
Phosphatidylcholine + phosphoethanolamine = 1-acylglycerophosphocholine + N-palmitoyl-phosphoethanolamine.
UniProtKB/Swiss-Prot Function:
Exhibits PLA1/2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor. Also catalyzes O-acylation converting lyso-PC into PC.

Enzyme Numbers (IUBMB) for HRASLS2 Gene

Gene Ontology (GO) - Molecular Function for HRASLS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with HRASLS2: view
genes like me logo Genes that share phenotypes with HRASLS2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HRASLS2 Gene

Localization for HRASLS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HRASLS2 Gene

Cytoplasm. Membrane; Single-pass membrane protein. Note=Exhibits a granular pattern in the cytoplasm with preferential perinuclear localization.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HRASLS2 gene
Compartment Confidence
cytosol 5
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for HRASLS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HRASLS2: view

Pathways & Interactions for HRASLS2 Gene

genes like me logo Genes that share pathways with HRASLS2: view

Interacting Proteins for HRASLS2 Gene

Gene Ontology (GO) - Biological Process for HRASLS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0016042 lipid catabolic process IEA --
genes like me logo Genes that share ontologies with HRASLS2: view

No data available for SIGNOR curated interactions for HRASLS2 Gene

Drugs & Compounds for HRASLS2 Gene

(2) Drugs for HRASLS2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
O-Phosphoethanolamine Experimental Pharma 0

(1) Additional Compounds for HRASLS2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N-palmitoyl-phosphoethanolamine
genes like me logo Genes that share compounds with HRASLS2: view

Transcripts for HRASLS2 Gene

mRNA/cDNA for HRASLS2 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HRASLS2 Gene

HRAS-like suppressor 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HRASLS2 Gene

No ASD Table

Relevant External Links for HRASLS2 Gene

GeneLoc Exon Structure for
HRASLS2
ECgene alternative splicing isoforms for
HRASLS2

Expression for HRASLS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HRASLS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HRASLS2 Gene

This gene is overexpressed in Colon - Transverse (x11.2), Small Intestine - Terminal Ileum (x9.4), Stomach (x7.0), and Kidney - Cortex (x5.8).

Protein differential expression in normal tissues from HIPED for HRASLS2 Gene

This gene is overexpressed in Pancreas (65.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HRASLS2 Gene



Protein tissue co-expression partners for HRASLS2 Gene

NURSA nuclear receptor signaling pathways regulating expression of HRASLS2 Gene:

HRASLS2

SOURCE GeneReport for Unigene cluster for HRASLS2 Gene:

Hs.272805

mRNA Expression by UniProt/SwissProt for HRASLS2 Gene:

Q9NWW9-HRSL2_HUMAN
Tissue specificity: Expressed in liver, kidney, small intestine testis and colon (PubMed:19615464). Undetectable in testis, placenta, salivary gland and fetal brain (PubMed:18163183).
genes like me logo Genes that share expression patterns with HRASLS2: view

Primer Products

Orthologs for HRASLS2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HRASLS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HRASLS2 34 35
  • 99.59 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 63 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 48 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 63 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch211-229n2.7 35
  • 28 (a)
ManyToMany
Species where no ortholog for HRASLS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HRASLS2 Gene

ENSEMBL:
Gene Tree for HRASLS2 (if available)
TreeFam:
Gene Tree for HRASLS2 (if available)

Paralogs for HRASLS2 Gene

Paralogs for HRASLS2 Gene

(4) SIMAP similar genes for HRASLS2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HRASLS2: view

Variants for HRASLS2 Gene

Sequence variations from dbSNP and Humsavar for HRASLS2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10128719 -- 63,561,348(+) ATAAA(C/T)GACTA intron-variant
rs111491401 -- 63,554,664(+) CGCAA(A/G)GCCAC intron-variant
rs111848953 -- 63,564,260(+) TGGGT(C/G)TGTAG intron-variant, upstream-variant-2KB
rs11231518 -- 63,554,958(+) GGAAA(A/G)AGCTG intron-variant
rs11231519 -- 63,556,045(+) AGCCT(A/T)ATTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HRASLS2 Gene

Variant ID Type Subtype PubMed ID
esv3626646 CNV gain 21293372
esv3626647 CNV gain 21293372
nsv352 CNV insertion 18451855
nsv509417 CNV insertion 20534489

Variation tolerance for HRASLS2 Gene

Residual Variation Intolerance Score: 64.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HRASLS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HRASLS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HRASLS2 Gene

Disorders for HRASLS2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HRASLS2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
poland syndrome
  • poland sequence
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HRASLS2

Genetic Association Database (GAD)
HRASLS2
Human Genome Epidemiology (HuGE) Navigator
HRASLS2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HRASLS2
genes like me logo Genes that share disorders with HRASLS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HRASLS2 Gene

Publications for HRASLS2 Gene

  1. Characterization of the human tumor suppressors TIG3 and HRASLS2 as phospholipid-metabolizing enzymes. (PMID: 19615464) Uyama T. … Ueda N. (Biochim. Biophys. Acta 2009) 3 4 22 64
  2. Cloning and functional characterization of the HRASLS2 gene. (PMID: 18163183) Shyu R.Y. … Jiang S.Y. (Amino Acids 2008) 3 4 22 64
  3. Structural basis for the acyltransferase activity of lecithin:retinol acyltransferase-like proteins. (PMID: 22605381) Golczak M. … Palczewski K. (J. Biol. Chem. 2012) 3 4 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for HRASLS2 Gene

Sources for HRASLS2 Gene

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