Aliases for HRASLS2 Gene
External Ids for HRASLS2 Gene
Previous GeneCards Identifiers for HRASLS2 Gene
The protein encoded by this gene has both phospholipase and acyltransferase activities and acts as a tumor suppressor. The encoded protein can hydrolyze dipalmitoylated phosphatidylcholine (PC) to palmitic acid and lyso-PC. In addition, this protein can catalyze the N-acylation of phosphatidylethanolamine and can catalyze the O-acylation of lyso-PC to form PC. [provided by RefSeq, Jul 2016]
GeneCards Summary for HRASLS2 Gene
HRASLS2 (HRAS Like Suppressor 2) is a Protein Coding gene. Diseases associated with HRASLS2 include Poland Syndrome. Among its related pathways are Metabolism and Acyl chain remodelling of PE. GO annotations related to this gene include hydrolase activity and transferase activity, transferring acyl groups. An important paralog of this gene is PLA2G16.
UniProtKB/Swiss-Prot for HRASLS2 Gene
Exhibits PLA1/2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor. Also catalyzes O-acylation converting lyso-PC into PC.