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HRASLS2 Gene

protein-coding   GIFtS: 45
GCID: GC11M063320

HRAS-Like Suppressor 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
HRAS-Like Suppressor 21 2
PLA1/2-22
EC 2.3.1.-3
EC 3.1.1.-3

External Ids:    HGNC: 178241   Entrez Gene: 549792   Ensembl: ENSG000001333287   OMIM: 6138665   UniProtKB: Q9NWW93   

Export aliases for HRASLS2 gene to outside databases

Previous GC identifers: GC11M065832 GC11M064896 GC11M063571 GC11M063095 GC11M063076 GC11M059649


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HRASLS2 Gene:
HRASLS2 (HRAS-like suppressor 2) is a protein-coding gene. GO annotations related to this gene include hydrolase activity and transferase activity, transferring acyl groups. An important paralog of this gene is PLA2G16.

UniProtKB/Swiss-Prot: HRSL2_HUMAN, Q9NWW9
Function: Exhibits PLA1/2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in various
phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher
than PLA2 activity. Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor.
Also catalyzes O-acylation converting lyso-PC into PC




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HRASLS2 gene promoter:
         JunB   GCNF   CUTL1   RORalpha1   FAC1   POU2F1   JunD   GCNF-1   POU2F1a   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHRASLS2 promoter sequence
   Search Chromatin IP Primers for HRASLS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HRASLS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.3   Ensembl cytogenetic band:  11q12.3   HGNC cytogenetic band: 11q12.2

HRASLS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HRASLS2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M063320:  view genomic region     (about GC identifiers)

Start:
63,320,242 bp from pter      End:
63,330,855 bp from pter
Size:
10,614 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HRSL2_HUMAN, Q9NWW9 (See protein sequence)
Recommended Name: HRAS-like suppressor 2  
Size: 162 amino acids; 17394 Da
1 PDB 3D structure from and Proteopedia for HRASLS2:
4DPZ (3D)    
Secondary accessions: B9A7L8

Explore the universe of human proteins at neXtProt for HRASLS2: NX_Q9NWW9

Explore proteomics data for HRASLS2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HRASLS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060348.1  
    ENSEMBL proteins: 
     ENSP00000255695  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007053 LRAT-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9NWW9

    ProtoNet protein and cluster: Q9NWW9

    1 Blocks protein domain: IPB007053 NC

    UniProtKB/Swiss-Prot: HRSL2_HUMAN, Q9NWW9
    Similarity: Belongs to the H-rev107 family


    Find genes that share domains with HRASLS2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HRSL2_HUMAN, Q9NWW9
    Function: Exhibits PLA1/2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in various
    phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher
    than PLA2 activity. Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor.
    Also catalyzes O-acylation converting lyso-PC into PC
    Catalytic activity: Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
    Catalytic activity: Phosphatidylcholine + H(2)O = 2-acylglycerophosphocholine + a carboxylate
    Catalytic activity: Phosphatidylcholine + phosphoethanolamine = 1-acylglycerophosphocholine +
    N-palmitoyl-phosphoethanolamine
    Biophysicochemical properties: Kinetic parameters: KM=300 uM for dipalmitoyl-PC; Vmax=670 nmol/min/mg enzyme with
    dipalmitoyl-PC as substrate; Vmax=122 nmol/min/mg enzyme with dipalmitoyl-PE as substrate; Vmax=103 nmol/min/mg
    enzyme using dipalmitoyl-PC as an acyl donor and PE as an acyl acceptor; pH dependence: Optimum pH is 8;

         Enzyme Numbers (IUBMB): EC 3.1.1.-1 EC 2.3.1.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016746transferase activity, transferring acyl groups IEA--
    GO:0016787hydrolase activity IEA--
         
    Find genes that share ontologies with HRASLS2           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for HRASLS2:
     Decreased Hepatitis C virus re  Decreased TP53 protein express  Increased Salmonella enterica   Increased Salmonella enterica  
     Increased Salmonella enterica   Increased Salmonella enterica  

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HRSL2_HUMAN, Q9NWW9: Cytoplasm. Membrane; Single-pass membrane protein. Note=Exhibits a granular pattern in the
    cytoplasm with preferential perinuclear localization
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol1
    endoplasmic reticulum1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with HRASLS2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HRASLS2
    Interactions:

        Search GeneGlobe Interaction Network for HRASLS2

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016042lipid catabolic process IEA--

    Find genes that share ontologies with HRASLS2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HRASLS2 (HRSL2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HRASLS2 gene: 
    NM_017878.1  

    Unigene Cluster for HRASLS2:

    HRAS-like suppressor 2
    Hs.272805  [show with all ESTs]
    Unigene Representative Sequence: AK025029
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000255695(uc001nxg.1)
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    Additional mRNA sequence: 

    AB453251.1 AK000563.1 AK025029.1 

    2 DOTS entries:

    DT.40246613  DT.92417502 

    14 AceView cDNA sequences:

    AK000563 BM757638 BM769124 NM_017878 BU686848 BQ083832 AK025029 BM819798 
    BM742602 BG998109 AI695341 C00599 BG202452 BG205041 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HRASLS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATCTTTATT
    HRASLS2 Expression
    About this image

    HRASLS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HRASLS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.272805

    UniProtKB/Swiss-Prot: HRSL2_HUMAN, Q9NWW9
    Tissue specificity: Expressed in liver, kidney, small intestine testis and colon (PubMed:19615464). Undetectable
    in testis, placenta, salivary gland and fetal brain (PubMed:18163183)

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HRASLS2 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    oppossum
    (Monodelphis domestica)
    Mammalia --
    --
    48(a)
    1 → many
    5(301213446-301226391)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    63(a)
    1 → many
    GL343890.1(19126-19575)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-229n2.76
    si:ch211-229n2.7
    28(a)
    many ↔ many
    8(14602845-14608837) ENSDARG00000094088


    ENSEMBL Gene Tree for HRASLS2 (if available)
    TreeFam Gene Tree for HRASLS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HRASLS2 gene
    PLA2G162  HRASLS2  RARRES32  HRASLS52  
    4 SIMAP similar genes for HRASLS2 using alignment to 1 protein entry:     HRSL2_HUMAN:
    PLA2G16    HRASLS    RARRES3    HRASLS5

    Find genes that share paralogs with HRASLS2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HRASLS2 (see all 303)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1381540701,2
    C--63319924(+) AGGCAC/GCTGCC 1 -- int10--------
    rs1912386101,2
    C--63319965(+) TAGAGA/GTGGGG 1 -- int10--------
    rs1438254391,2
    C--63319993(+) GGCTGG/TTCTCG 1 -- int10--------
    rs19738111,2
    C--63320029(+) CACCTC/TGGCCT 1 -- int10--------
    rs1841483711,2
    --63320038(+) CTCCCA/GAAGTG 1 -- int10--------
    rs1885555631,2
    --63320075(+) GCCCGA/GTCTAG 1 -- int10--------
    rs1928335281,2
    --63320078(+) CGGTCC/TAGTCT 1 -- int10--------
    rs1852220531,2
    --63320091(+) TCCTTC/TTCATA 1 -- int10--------
    rs15546561,2
    C,F,H--63320239(+) AGTCCA/GTAGCA 1 -- int118Minor allele frequency- G:0.37EA NS NA WA 2512
    rs1901212961,2
    --63320339(+) CATGAA/GCACAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for HRASLS2 (63320242 - 63330855 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HRASLS2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv352CNV Insertion18451855
    nsv509417CNV Insertion20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HRASLS2
    DNA2.0 Custom Variant and Variant Library Synthesis for HRASLS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613866    OMIM disorders: --


    Find genes that share disorders with HRASLS2           About GenesLikeMe

    Genetic Association Database (GAD): HRASLS2
    Human Genome Epidemiology (HuGE) Navigator: HRASLS2 (3 documents)

    Export disorders for HRASLS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HRASLS2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with HRASLS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional characterization of the HRASLS2 gene. (PubMed id 18163183)1, 2, 9 Shyu R.Y.... Jiang S.Y. (Amino Acids 2008)
    2. Characterization of the human tumor suppressors TIG3 and HRASLS2 as phospholipid-metabolizing enzymes. (PubMed id 19615464)1, 2, 9 Uyama T.... Ueda N. (Biochim. Biophys. Acta 2009)
    3. Structural basis for the acyltransferase activity of lecithin:retinol acyltransferase-like proteins. (PubMed id 22605381)1, 2 Golczak M....Palczewski K. (J. Biol. Chem. 2012)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54979 HGNC: 17824 AceView: HRASLS2 Ensembl:ENSG00000133328 euGenes: HUgn54979
    ECgene: HRASLS2 H-InvDB: HRASLS2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HRASLS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HRASLS2 gene:
    Search GeneIP for patents involving HRASLS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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