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Aliases for HRASLS2 Gene

Aliases for HRASLS2 Gene

  • HRAS-Like Suppressor 2 2 3
  • EC 2.3.1.- 4
  • EC 3.1.1.- 4
  • PLA1/2-2 3

External Ids for HRASLS2 Gene

Summaries for HRASLS2 Gene

GeneCards Summary for HRASLS2 Gene

HRASLS2 (HRAS-Like Suppressor 2) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity and transferase activity, transferring acyl groups. An important paralog of this gene is RARRES3.

UniProtKB/Swiss-Prot for HRASLS2 Gene

  • Exhibits PLA1/2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor. Also catalyzes O-acylation converting lyso-PC into PC.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HRASLS2 Gene

Genomics for HRASLS2 Gene

Genomic Location for HRASLS2 Gene

Start:
63,552,770 bp from pter
End:
63,563,383 bp from pter
Size:
10,614 bases
Orientation:
Minus strand

Genomic View for HRASLS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HRASLS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HRASLS2 Gene

Regulatory Elements for HRASLS2 Gene

Proteins for HRASLS2 Gene

  • Protein details for HRASLS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWW9-HRSL2_HUMAN
    Recommended name:
    HRAS-like suppressor 2
    Protein Accession:
    Q9NWW9
    Secondary Accessions:
    • B9A7L8

    Protein attributes for HRASLS2 Gene

    Size:
    162 amino acids
    Molecular mass:
    17394 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HRASLS2 Gene

neXtProt entry for HRASLS2 Gene

Proteomics data for HRASLS2 Gene at MOPED

Post-translational modifications for HRASLS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HRASLS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HRASLS2 Gene

Domains for HRASLS2 Gene

Protein Domains for HRASLS2 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

HRSL2_HUMAN
Family:
  • Belongs to the H-rev107 family.:
    • Q9NWW9
genes like me logo Genes that share domains with HRASLS2: view

No data available for Gene Families for HRASLS2 Gene

Function for HRASLS2 Gene

Molecular function for HRASLS2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=300 uM for dipalmitoyl-PC {ECO:0000269 PubMed:19615464}; Vmax=670 nmol/min/mg enzyme with dipalmitoyl-PC as substrate {ECO:0000269 PubMed:19615464}; Vmax=122 nmol/min/mg enzyme with dipalmitoyl-PE as substrate {ECO:0000269 PubMed:19615464}; Vmax=103 nmol/min/mg enzyme using dipalmitoyl-PC as an acyl donor and PE as an acyl acceptor {ECO:0000269 PubMed:19615464}; pH dependence: Optimum pH is 8. {ECO:0000269 PubMed:19615464};
UniProtKB/Swiss-Prot CatalyticActivity: Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot CatalyticActivity: Phosphatidylcholine + H(2)O = 2-acylglycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot CatalyticActivity: Phosphatidylcholine + phosphoethanolamine = 1-acylglycerophosphocholine + N-palmitoyl-phosphoethanolamine.
UniProtKB/Swiss-Prot Function: Exhibits PLA1/2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor. Also catalyzes O-acylation converting lyso-PC into PC.

Enzyme Numbers (IUBMB) for HRASLS2 Gene

Gene Ontology (GO) - Molecular Function for HRASLS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with HRASLS2: view
genes like me logo Genes that share phenotypes with HRASLS2: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HRASLS2 Gene

Localization for HRASLS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HRASLS2 Gene

Cytoplasm. Membrane; Single-pass membrane protein. Note=Exhibits a granular pattern in the cytoplasm with preferential perinuclear localization.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HRASLS2 Gene COMPARTMENTS Subcellular localization image for HRASLS2 gene
Compartment Confidence
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HRASLS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HRASLS2: view

Pathways for HRASLS2 Gene

SuperPathways for HRASLS2 Gene

No Data Available

Interacting Proteins for HRASLS2 Gene

Gene Ontology (GO) - Biological Process for HRASLS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016042 lipid catabolic process IEA --
genes like me logo Genes that share ontologies with HRASLS2: view

No data available for Pathways by source for HRASLS2 Gene

Transcripts for HRASLS2 Gene

mRNA/cDNA for HRASLS2 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HRASLS2 Gene

HRAS-like suppressor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HRASLS2 Gene

No ASD Table

Relevant External Links for HRASLS2 Gene

GeneLoc Exon Structure for
HRASLS2
ECgene alternative splicing isoforms for
HRASLS2

Expression for HRASLS2 Gene

mRNA expression in normal human tissues for HRASLS2 Gene

mRNA differential expression in normal tissues according to GTEx for HRASLS2 Gene

This gene is overexpressed in Colon - Transverse (11.2), Small Intestine - Terminal Ileum (9.4), Stomach (7.0), and Kidney - Cortex (5.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for HRASLS2 Gene

SOURCE GeneReport for Unigene cluster for HRASLS2 Gene Hs.272805

mRNA Expression by UniProt/SwissProt for HRASLS2 Gene

Q9NWW9-HRSL2_HUMAN
Tissue specificity: Expressed in liver, kidney, small intestine testis and colon (PubMed:19615464). Undetectable in testis, placenta, salivary gland and fetal brain (PubMed:18163183).
genes like me logo Genes that share expressions with HRASLS2: view

Orthologs for HRASLS2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HRASLS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HRASLS2 36
  • 99.59 (n)
  • 99.38 (a)
HRASLS2 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 48 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 63 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 63 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch211-229n2.7 37
  • 28 (a)
ManyToMany
Species with no ortholog for HRASLS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HRASLS2 Gene

ENSEMBL:
Gene Tree for HRASLS2 (if available)
TreeFam:
Gene Tree for HRASLS2 (if available)

Paralogs for HRASLS2 Gene

Paralogs for HRASLS2 Gene

Selected SIMAP similar genes for HRASLS2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HRASLS2: view

Variants for HRASLS2 Gene

Sequence variations from dbSNP and Humsavar for HRASLS2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs649660 -- 63,555,735(+) gatgt(C/G)cacag intron-variant
rs940614 -- 63,559,946(+) TAGCA(A/G)GAAAA intron-variant
rs948796 -- 63,559,714(+) CCCAC(A/G)TGCTC intron-variant
rs1554656 -- 63,552,767(+) AGTCC(A/G)TAGCA downstream-variant-500B
rs1722854 -- 63,552,351(+) ccagc(C/G)tggag downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for HRASLS2 Gene

Variant ID Type Subtype PubMed ID
nsv509417 CNV Insertion 20534489
nsv352 CNV Insertion 18451855

Relevant External Links for HRASLS2 Gene

HapMap Linkage Disequilibrium report
HRASLS2

Disorders for HRASLS2 Gene

Relevant External Links for HRASLS2

Genetic Association Database (GAD)
HRASLS2
Human Genome Epidemiology (HuGE) Navigator
HRASLS2
genes like me logo Genes that share disorders with HRASLS2: view

No data available for UniProtKB/Swiss-Prot for HRASLS2 Gene

Publications for HRASLS2 Gene

  1. Cloning and functional characterization of the HRASLS2 gene. (PMID: 18163183) Shyu R.Y. … Jiang S.Y. (Amino Acids 2008) 3 4 23
  2. Characterization of the human tumor suppressors TIG3 and HRASLS2 as phospholipid-metabolizing enzymes. (PMID: 19615464) Uyama T. … Ueda N. (Biochim. Biophys. Acta 2009) 3 4 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 49
  5. Structural basis for the acyltransferase activity of lecithin:retinol acyltransferase-like proteins. (PMID: 22605381) Golczak M. … Palczewski K. (J. Biol. Chem. 2012) 3 4

Products for HRASLS2 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate HRASLS2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for HRASLS2
    • Block miRNA regulation of HRASLS2 using miScript Target Protectors
    • antibodies-online peptides for HRASLS2
    • antibodies-online antibodies for HRASLS2
    • antibodies-online kits for HRASLS2

    Sources for HRASLS2 Gene

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