HRASLS Gene
protein-coding GIFtS: 47
GCID: GC03P192958
|
|
HRAS-like suppressor
| |
Aliases
for HRASLS gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| HRAS-Like Suppressor1 2 | | HSD282 | | H-REV1071 2 | | H-REV107 Protein-Related Protein2 | | HRASLS11 2 | | Phospholipase A2 | | HRSL12 3 | | Phospholipid-Metabolizing Enzyme A-C12 | | HRAS-Like Suppressor 12 3 | | EC 2.3.1.-3 | | A-C12 | | EC 3.1.1.-3 |
Export aliases for HRASLS gene to outside databasesPrevious GC identifers: GC03P190025 GC03P194220 GC03P194360 GC03P194279 GC03P194441 GC03P190346 |
Summaries
for HRASLS gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: HRSL1_HUMAN, Q9HDD0Function: Exhibits calcium-independent phospholipase activity towards phosphatidylcholine (PC) andphosphatidylethanolamine (PE). Also shows acyltransferase activities, transferring an acyl group of PCs to the aminogroup of PEs and the hydroxyl group of lyso PCs
|
Genomic Views
for HRASLS gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HRASLS gene promoter:
MEF-2A TBP AREB6 Tal-1 MEF-2 TFIID HTF HSF2 aMEF-2 E47
Other transcription factors
Search SABiosciences Chromatin IP Primers for HRASLS
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HRASLS |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q29 Ensembl cytogenetic band: 3q29 HGNC cytogenetic band: 3q29HRASLS Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P192958: view genomic region
(about GC identifiers)
Start:
|
192,958,914 bp from pter |
End:
|
192,995,527 bp from pter |
Size:
|
36,614 bases |
Orientation:
|
plus strand |
|
Proteins
for HRASLS gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HRSL1_HUMAN, Q9HDD0 (See
protein sequence)Recommended Name: Phospholipid-metabolizing enzyme A-C1 Size: 168 amino acids; 18750 Da
Subcellular location: Membrane; Single-pass membrane protein (By similarity)
Secondary accessions: D2KX19Explore the universe of human proteins at neXtProt for HRASLS: NX_Q9HDD0
HRASLS Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_065119.2
ENSEMBL proteins: ENSP00000264735 ENSP00000414431
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
HRASLS for ontologies About GeneDecksing
HRASLS Antibody Products:
Assay Products for HRASLS: |
Protein
Domains /
Families
for HRASLS gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HRASLS for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9HDD0ProtoNet protein and cluster: Q9HDD0 1 Blocks protein family: IPB007053 NC
UniProtKB/Swiss-Prot: HRSL1_HUMAN, Q9HDD0Similarity: Belongs to the H-rev107 family |
Function
for HRASLS gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: HRSL1_HUMAN, Q9HDD0Function: Exhibits calcium-independent phospholipase activity towards phosphatidylcholine (PC) andphosphatidylethanolamine (PE). Also shows acyltransferase activities, transferring an acyl group of PCs to the aminogroup of PEs and the hydroxyl group of lyso PCsEnzyme Numbers (IUBMB): EC 3.1.1.-1 EC 2.3.1.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HRASLS (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HRASLS
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HRASLS (NM_017878) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HRASLS | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HRASLS |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRASLS |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
HRASLS for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for HRASLS:
|
Pathways & Interactions
for HRASLS gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HRASLS
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007031 | peroxisome organization |
IEA | -- | | GO:0016042 | lipid catabolic process |
IEA | -- | | GO:0046485 | ether lipid metabolic process |
IEA | -- |
HRASLS for ontologies About GeneDecksing
|
Drugs & Compounds
for HRASLS gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HRASLS
Search CenterWatch for drugs/clinical trials and news about HRASLS / HRSL1
|
Transcripts
for HRASLS gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HRASLS gene: NM_020386.4 Unigene Cluster for HRASLS: HRAS-like suppressor Hs.36761 [show with all ESTs]Unigene Representative Sequence: BC0480952 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000264735(uc003fta.3) ENST00000416012
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HRASLS (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HRASLS
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HRASLS (NM_017878) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HRASLS | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HRASLS |
Additional cDNA sequence: AB030816.1 AB510981.1 AY251533.1 BC048095.1 3 DOTS entries: DT.213305 DT.120860918 DT.95318370 24/32 AceView cDNA sequences (see all 32): BM671352 AB030816 BU541990 BM692792 F32781 NM_020386 AI159761 AI039534 BG718302 AI703120 AI805320 AA608560 AI148017 AA404482 AY251533 AI018579 AA496124 BG717629 AA496125 AI989666 AI824880 BE671858 BF061734 BC048095
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for HRASLS About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 |
|---|
|
| SP1: | | | | | | | | | | | |
| SP2: | | | | | | | | | | |
ECgene alternative splicing isoforms for HRASLS
|
Expression
for HRASLS gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HRASLS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCAGAGCCT
About this image
See HRASLS Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HRASLS
SOURCE GeneReport for Unigene cluster: Hs.36761
UniProtKB/Swiss-Prot: HRSL1_HUMAN, Q9HDD0Tissue specificity: Abundantly expressed in testis, skeletal muscle, brain, and heart
SABiosciences Custom PCR Arrays for HRASLS
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HRASLS
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HRASLS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HRASLS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HRASLS | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRASLS |
Orthologs
for HRASLS gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for HRASLS gene from 2/9 species (see all 9) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
HRASLS1 |
HRAS-like suppressor |
69.64(n)
73.21(a) |
|
424903 XM_422714.3 XP_422714.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.195932 |
Transcribed sequence with weak similarity to protein more |
74.49(n) |
|
CK355737.1 |
ENSEMBL Gene Tree for HRASLS (if available)
TreeFam Gene Tree for HRASLS (if available) |
Paralogs
for HRASLS gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HRASLS gene
- PLA2G162 RARRES32 HRASLS22 HRASLS52
4 SIMAP similar genes for HRASLS using alignment to 3 protein entries: HRSL1_HUMAN (see all proteins):HRASLS2 PLA2G16 HRASLS5 RARRES3
HRASLS for paralogs About GeneDecksing
|
Genomic Variants
for HRASLS gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HRASLS (192958914 - 192995527 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for HRASLS
1 CNV: 3470 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HRASLS |
|
Disorders
/ Diseases
for HRASLS gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HRASLS for disorders About GeneDecksing
OMIM gene information: 606487
OMIM disorders: --
5  diseases for HRASLS: About MalaCardsgastric cancer cervical cancer cervicitis lung cancer
carcinoma
2 Novoseek disease relationships for HRASLS gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| gastric cancer |
54.2 |
6 |
15374948 (3), 12438262 (2), 16707594 (1) |
| tumors |
8.26 |
1 |
15374948 (1) |
Export disorders for HRASLS gene to outside databases
|
Publications
for HRASLS gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HRASLS gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with HRASLS) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Enzymological analysis of the tumor suppressor A-C1 r eveals a novel group of phospholipid-metabolizing enzymes. (PubMed id 21880860)1, 2 Shinohara N....Ueda N. (2011)
- Isolation, characterization, and chromosome mapping of a human A-C1 Ha-Ras suppressor gene (HRASLS). (PubMed id 11474175)1, 9 Ito H....Nakamura T. (2001)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Solution structure of the N-terminal catalytic domain of human H-REV107--a novel circular permutated NlpC/P60 domain. (PubMed id 20837014)1 Ren X....Xia B. (2010)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Molecular cloning and biological activity of a novel Ha-Ras suppressor gene predominantly expressed in skeletal muscle, heart, brain, and bone marrow by differential display using clonal mouse EC cells, ATDC5. (PubMed id 10542256)1 Akiyama H....Nakamura T. (1999)
- Transcriptional and translational downregulation of H-REV107, a class II tumour suppressor gene located on human chromosome 11q11-12. (PubMed id 9771974)1 Husmann K.... Schafer R. (1998)
- Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers. (PubMed id 15374948)9 Kaneda A....Ushijima T. (2004)
- CpG island promoter hypermethylation of the Ras-effector gene NORE1A occurs in the context of a wild-type K-ras in lung cancer. (PubMed id 15378027)9 Irimia M....Esteller M. (2004)
|
External Searches for HRASLS gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HRASLS gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HRASLS gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HRASLS gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for HRASLS gene:
Search GeneIP for patents involving HRASLS
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HRASLS gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HRASLS | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HRASLS | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HRASLS | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HRASLS | | OriGene 3'-UTR Clone for HRASLS | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HRASLS | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HRASLS | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HRASLS | | OriGene Custom Protein Services for HRASLS | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HRASLS | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HRASLS | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HRASLS | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HRASLS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HRASLS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HRASLS |
| |
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| | | | Search Tocris compounds for HRASLS |
| |  |  |  |  | | | | |
 |
 |
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 | | | HRASLS Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRASLS |
|  |  |  | | | | ThermoFisher Antibody for HRASLS |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HRASLS |
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