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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HRASLS Gene

protein-coding   GIFtS: 47
GCID: GC03P192958

HRAS-Like Suppressor

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
HRAS-Like Suppressor1 2     HSD282
HRSL12 3     H-REV107 Protein-Related Protein2
HRAS-Like Suppressor 12 3     Phospholipase A2
A-C12     Phospholipid-Metabolizing Enzyme A-C12
H-REV1072     EC 2.3.1.-3
HRASLS12     EC 3.1.1.-3

External Ids:    HGNC: 149221   Entrez Gene: 571102   Ensembl: ENSG000001272527   OMIM: 6064875   UniProtKB: Q9HDD03   

Export aliases for HRASLS gene to outside databases

Previous GC identifers: GC03P190025 GC03P194220 GC03P194360 GC03P194279 GC03P194441 GC03P190346


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for HRASLS Gene: 
HRASLS (HRAS-like suppressor) is a protein-coding gene. Diseases associated with HRASLS include gastric cancer, and cervical cancer. GO annotations related to this gene include phospholipase activity and transferase activity. An important paralog of this gene is PLA2G16.

UniProtKB/Swiss-Prot: HRSL1_HUMAN, Q9HDD0
Function: Exhibits calcium-independent phospholipase activity towards phosphatidylcholine (PC) and
phosphatidylethanolamine (PE). Also shows acyltransferase activities, transferring an acyl group of PCs to the
amino group of PEs and the hydroxyl group of lyso PCs




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HRASLS gene promoter:
         MEF-2A   TBP   AREB6   Tal-1   MEF-2   TFIID   HTF   HSF2   aMEF-2   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHRASLS promoter sequence
   Search SABiosciences Chromatin IP Primers for HRASLS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HRASLS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q29   Ensembl cytogenetic band:  3q29   HGNC cytogenetic band: 3q29

HRASLS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HRASLS gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P192958:  view genomic region     (about GC identifiers)

Start:
192,958,914 bp from pter      End:
192,995,527 bp from pter
Size:
36,614 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HRSL1_HUMAN, Q9HDD0 (See protein sequence)
Recommended Name: Phospholipid-metabolizing enzyme A-C1  
Size: 168 amino acids; 18750 Da
Subcellular location: Membrane; Single-pass membrane protein (By similarity)
Secondary accessions: D2KX19

Explore the universe of human proteins at neXtProt for HRASLS: NX_Q9HDD0

Explore proteomics data for HRASLS at MOPED 

HRASLS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

HRASLS Protein Expression

REFSEQ proteins: NP_065119.2  
ENSEMBL proteins: 
 ENSP00000264735   ENSP00000414431   ENSP00000473258  

Human Recombinant Protein Products for HRASLS: 
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Novus Biologicals HRASLS Proteins
Novus Biologicals HRASLS Lysate
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Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for HRASLS 

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005641nuclear envelope lumen IEA--
GO:0005737cytoplasm ----
GO:0005777peroxisome IEA--
GO:0016021integral to membrane IEA--

HRASLS for ontologies           About GeneDecksing



HRASLS Antibody Products: 
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LSBio Antibodies in human, mouse, rat for HRASLS 

Assay Products for HRASLS: 
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Cloud-Clone Corp. ELISAs for HRASLS 
Cloud-Clone Corp. CLIAs for HRASLS


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR007053 LRAT-like_dom

Graphical View of Domain Structure for InterPro Entry Q9HDD0

ProtoNet protein and cluster: Q9HDD0

1 Blocks protein domain: IPB007053 NC

UniProtKB/Swiss-Prot: HRSL1_HUMAN, Q9HDD0
Similarity: Belongs to the H-rev107 family


HRASLS for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: HRSL1_HUMAN, Q9HDD0
Function: Exhibits calcium-independent phospholipase activity towards phosphatidylcholine (PC) and
phosphatidylethanolamine (PE). Also shows acyltransferase activities, transferring an acyl group of PCs to the
amino group of PEs and the hydroxyl group of lyso PCs

     Enzyme Numbers (IUBMB): EC 3.1.1.-1 EC 2.3.1.-1

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004620phospholipase activity IEA--
GO:0016740transferase activity IEA--
     
HRASLS for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for HRASLS:
 Decreased melanin production 

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for HRASLS 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HRASLS

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HRASLS 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HRASLS 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HRASLS
1 QIAGEN miScript miRNA Assays for microRNA that regulate HRASLS:
hsa-miR-3647-3p
SwitchGear 3'UTR luciferase reporter plasmidHRASLS 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for HRASLS
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HRASLS

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for HRASLS
Sirion Biotech Customized adenovirus for overexpression of HRASLS

Clone
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OriGene clones in human, mouse for HRASLS (see all 7)
OriGene ORF clones in mouse, rat for HRASLS
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: HRASLS (NM_017878)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HRASLS
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HRASLS
Sirion Biotech Customized lentivirus for stable overexpression of HRASLS 
                     Customized lentivirus expression plasmids for stable overexpression of HRASLS 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for HRASLS
Search LifeMap BioReagents cell lines for HRASLS
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRASLS


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HRASLS

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007031peroxisome organization IEA--
GO:0016042lipid catabolic process IEA--
GO:0046485ether lipid metabolic process IEA--

HRASLS for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HRASLS (HRSL1)

Search CenterWatch for drugs/clinical trials and news about HRASLS / HRSL1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HRASLS gene: 
NM_020386.4  

Unigene Cluster for HRASLS:

HRAS-like suppressor
Hs.36761  [show with all ESTs]
Unigene Representative Sequence: BC048095
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000264735(uc003fta.3) ENST00000416012 ENST00000602513
miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HRASLS
1 QIAGEN miScript miRNA Assays for microRNA that regulate HRASLS:
hsa-miR-3647-3p
SwitchGear 3'UTR luciferase reporter plasmidHRASLS 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for HRASLS
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HRASLS
Clone
Products:
     
OriGene clones in human, mouse for HRASLS (see all 7)
OriGene ORF clones in mouse, rat for HRASLS
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: HRASLS (NM_017878)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HRASLS
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HRASLS
Sirion Biotech Customized lentivirus for stable overexpression of HRASLS 
                     Customized lentivirus expression plasmids for stable overexpression of HRASLS 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for HRASLS
OriGene qSTAR qPCR primer pairs in human, mouse for HRASLS
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HRASLS
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HRASLS
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HRASLS

Additional mRNA sequence: 

AB030816.1 AB510981.1 AY251533.1 BC048095.1 

3 DOTS entries:

DT.213305  DT.120860918  DT.95318370 

24/32 AceView cDNA sequences (see all 32):

NM_020386 F32781 BM671352 BU541990 BM692792 AB030816 AI159761 AI805320 
BG717629 AA496124 BC048095 AY251533 BG718302 BE671858 AI148017 AI018579 
AA496125 AA608560 AI989666 AA404482 AI703120 AI824880 AI039534 BF061734 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for HRASLS    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
SP1:                              
SP2:                              


ECgene alternative splicing isoforms for HRASLS

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HRASLS expression in normal human tissues (normalized intensities)      HRASLS embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GTCAGAGCCT
HRASLS Expression
About this image


HRASLS expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/5 selected tissues (see all 5) fully expand
 
 Brain (Nervous System)    fully expand to see all 18 entries
         Thalamus
         Septum   
 
 Testis (Reproductive System)    fully expand to see all 3 entries
         Leydig Cells Testis Interstitium
         Testis Interstitium
 
 Spinal Cord (Nervous System)    fully expand to see all 2 entries
         Dorsal Horn   
 
 Endothelium (Cardiovascular System)
         Human umbilical vein endothelial cells (HUVEC)
 
 Ovary (Reproductive System)

See HRASLS Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HRASLS

SOURCE GeneReport for Unigene cluster: Hs.36761

UniProtKB/Swiss-Prot: HRSL1_HUMAN, Q9HDD0
Tissue specificity: Abundantly expressed in testis, skeletal muscle, brain, and heart

    SABiosciences Custom PCR Arrays for HRASLS
Primer
Products:
OriGene qPCR primer pairs and template standards for HRASLS
OriGene qSTAR qPCR primer pairs in human, mouse for HRASLS
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HRASLS
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HRASLS
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HRASLS
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRASLS

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for HRASLS gene from 4/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Hrasls1 , 5 HRAS-like suppressor1, 5 83.83(n)1
84.43(a)1
  16 (20.01 cM)5
272811  NM_013751.51  NP_038779.21 
 292096955 
chicken
(Gallus gallus)
Aves HRASLS1 HRAS-like suppressor 69.64(n)
73.21(a)
  424903  XM_422714.3  XP_422714.1 
lizard
(Anolis carolinensis)
Reptilia --
--
(see all 5)
Uncharacterized protein
(see all 5)
40(a)
36(a)
(see all 5)
possible ortholog
possible ortholog
(see all 5)
6(38295851-38298037)
5(91215549-91218762)
zebrafish
(Danio rerio)
Actinopterygii Dr.195932 Transcribed sequence with weak similarity to protein more 74.49(n)    CK355737.1 


ENSEMBL Gene Tree for HRASLS (if available)
TreeFam Gene Tree for HRASLS (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for HRASLS gene
PLA2G162  HRASLS22  RARRES32  HRASLS52  
4 SIMAP similar genes for HRASLS using alignment to 3 protein entries:     HRSL1_HUMAN (see all proteins):
HRASLS2    PLA2G16    HRASLS5    RARRES3

HRASLS for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/599 SNPs in HRASLS are shown (see all 599)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs607171201,2
C--192838474(+) TTTTT-/CTGGCCA 1 -- int11Minor allele frequency- CT:0.00NA 2
rs1502159781,2
C--192957055(+) ACTCTC/TACTAT 1 -- us2k10--------
rs1388116911,2
--192957070(+) TTAGGC/TAGCAA 1 -- us2k10--------
rs745790711,2
C,F--192957089(+) GCCAGC/ACACAC 1 -- us2k11Minor allele frequency- A:0.04WA 118
rs1824398701,2
--192957165(+) CCAATC/GATAGC 1 -- us2k10--------
rs1879654741,2
--192957208(+) TGCCTA/GTTACT 1 -- us2k10--------
rs1924427451,2
--192957272(+) TCATCC/TGTAGA 1 -- us2k10--------
rs1494972991,2
C--192957352(+) TACAAC/TGCTTT 1 -- us2k10--------
rs794883081,2
--192957431(+) TATACC/GTGGCA 1 -- us2k10--------
rs1153100761,2
F--192962262(+) GTTTTT/GTTTTT 1 -- int11Minor allele frequency- G:0.02WA 118

HapMap Linkage Disequilibrium report for HRASLS (192958914 - 192995527 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for HRASLS:    About this table     
Variant IDTypeSubtypePubMed ID
esv2660978CNV Deletion23128226
nsv428429CNV Gain18775914
nsv878123CNV Gain21882294
dgv1546e1CNV Complex17122850

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing HRASLS
DNA2.0 Custom Variant and Variant Library Synthesis for HRASLS

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 606487    OMIM disorders: --

4 diseases for HRASLS:    About MalaCards
gastric cancer    cervical cancer    cervicitis    lung cancer


HRASLS for disorders           About GeneDecksing

2 Novoseek inferred disease relationships for HRASLS gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
gastric cancer 54.2 6 15374948 (3), 12438262 (2), 16707594 (1)
tumors 8.26 1 15374948 (1)


Export disorders for HRASLS gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for HRASLS gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with HRASLS)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Enzymological analysis of the tumor suppressor A-C1 r eveals a novel group of phospholipid-metabolizing enzymes. (PubMed id 21880860)1, 2 Shinohara N....Ueda N. (2011)
  2. Isolation, characterization, and chromosome mapping of a human A-C1 Ha-Ras suppressor gene (HRASLS). (PubMed id 11474175)1, 9 Ito H....Nakamura T. (2001)
  3. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
  4. Solution structure of the N-terminal catalytic domain of human H-REV107--a novel circular permutated NlpC/P60 domain. (PubMed id 20837014)1 Ren X....Xia B. (2010)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  6. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
  7. Molecular cloning and biological activity of a novel Ha-Ras suppressor gene predominantly expressed in skeletal muscle, heart, brain, and bone marrow by differential display using clonal mouse EC cells, ATDC5. (PubMed id 10542256)1 Akiyama H....Nakamura T. (1999)
  8. Transcriptional and translational downregulation of H-REV107, a class II tumour suppressor gene located on human chromosome 11q11-12. (PubMed id 9771974)1 Husmann K.... Schafer R. (1998)
  9. Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers. (PubMed id 15374948)9 Kaneda A....Ushijima T. (2004)
  10. CpG island promoter hypermethylation of the Ras-effector gene NORE1A occurs in the context of a wild-type K-ras in lung cancer. (PubMed id 15378027)9 Irimia M....Esteller M. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 57110 HGNC: 14922 AceView: HRASLS Ensembl:ENSG00000127252 euGenes: HUgn57110
ECgene: HRASLS H-InvDB: HRASLS

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for HRASLS Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for HRASLS Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for HRASLS gene:
Search GeneIP for patents involving HRASLS

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 EMD Millipore Custom Antibody & Bulk Services
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 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for HRASLS  
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 OriGene Custom Antibody Services for HRASLS   OriGene Custom Protein Services for HRASLS  

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HRASLS
 QIAGEN SeqTarget long-range PCR primers for resequencing HRASLS
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HRASLS
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HRASLS
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 GenScript Custom Purified and Recombinant Proteins Services for HRASLS GenScript cDNA clones with any tag delivered in your preferred vector for HRASLS
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 GenScript Custom overexpressing Cell Line Services for HRASLS CloneReady with Over 120,000 Genes
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 Regulatory tfbs in HRASLS promoter
 Search Chromatin IP Primers for HRASLS
 RT2 qPCR Primer Assay in human, mouse, rat HRASLS
 Search GNC Networks for HRASLS
 SABiosciences Custom PCR Arrays for HRASLS
 Search Tocris compounds for HRASLS (HRSL1)
 Browse Sino Biological Proteins and Antibodies
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
 HRASLS antibodies
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 See all of Abcam's Antibodies, Kits and Proteins for HRASLS
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 Proteins for HRASLS
 Antibodies for HRASLS
 ELISAs for HRASLS
 CLIAs for HRASLS
 Search LifeMap BioReagents cell lines for HRASLS
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRASLS
 SwitchGear 3'UTR luciferase reporter plasmids for HRASLS
 SwitchGear Promoter luciferase reporter plasmids for HRASLS
 ThermoFisher Antibodies for HRASLS
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HRASLS
 inGenious Targeting Laboratory - Custom generated mouse model solutions for HRASLS
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HRASLS
Customized:
 lentivirus for stable overexpression of HRASLS
 lentivirus expression plasmids for stable overexpression of HRASLS
 adenovirus for overexpression of HRASLS
 LSBio Antibodies in human, mouse, rat for HRASLS
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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(GIFtS: 73)
transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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