Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HRASLS Gene

Aliases for HRASLS Gene

  • HRAS Like Suppressor 2 3 5
  • HRAS-Like Suppressor 1 3 4
  • HRSL1 3 4
  • Phospholipid-Metabolizing Enzyme A-C1 3
  • H-REV107 Protein-Related Protein 3
  • Phospholipase A 3
  • EC 2.3.1.- 4
  • EC 3.1.1.- 4
  • H-REV107 3
  • HRASLS1 3
  • HSD28 3
  • A-C1 3

External Ids for HRASLS Gene

Previous GeneCards Identifiers for HRASLS Gene

  • GC03P190025
  • GC03P194220
  • GC03P194360
  • GC03P194279
  • GC03P194441
  • GC03P192958
  • GC03P190346

Summaries for HRASLS Gene

GeneCards Summary for HRASLS Gene

HRASLS (HRAS Like Suppressor) is a Protein Coding gene. Diseases associated with HRASLS include Gastric Cancer, Somatic. Among its related pathways are Metabolism and Acyl chain remodelling of PE. GO annotations related to this gene include hydrolase activity and phospholipase activity. An important paralog of this gene is PLA2G16.

UniProtKB/Swiss-Prot for HRASLS Gene

  • Exhibits calcium-independent phospholipase activity towards phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Also shows acyltransferase activities, transferring an acyl group of PCs to the amino group of PEs and the hydroxyl group of lyso PCs.

Additional gene information for HRASLS Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HRASLS Gene

Genomics for HRASLS Gene

Regulatory Elements for HRASLS Gene

Enhancers for HRASLS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H193959 1.3 VISTA ENCODE 5.7 +719.9 719931 2.7 INSM2 ZNF223 KLF17 FEZF1 ZIC2 ZNF2 ZFHX2 GLIS2 ZNF366 PATZ1 ENSG00000232874 HES1 CPN2 HRASLS ENSG00000238043 LOC105374287
GH03H193392 0.5 ENCODE 10.8 +151.0 150982 0.2 STAT1 ZNF687 FOS ZIC2 WT1 HRASLS VEZF1P1 ATP13A5 ATP13A4-AS1
GH03H193240 0.9 ENCODE 5.7 +0.2 152 2.1 ZSCAN4 INSM2 ZNF76 GLI4 EGR1 SCRT2 ZNF391 EGR2 ZNF280D YY2 VEZF1P1 ATP13A5-AS1 HRASLS MGC2889
GH03H193347 0.5 ENCODE 9.9 +107.3 107341 1.3 MXI1 RFX1 POLR2A RUNX3 BATF ATP13A5 ATP13A5-AS1 HRASLS GC03M193345
GH03H193388 0.2 ENCODE 7.8 +148.2 148226 0.7 HRASLS ATP13A5 ATP13A4-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HRASLS on UCSC Golden Path with GeneCards custom track

Promoters for HRASLS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000163945 -25 1001 ZSCAN4 INSM2 ZNF76 GLI4 EGR1 SCRT2 ZNF391 EGR2 ZNF280D YY2

Genomic Locations for HRASLS Gene

Genomic Locations for HRASLS Gene
chr3:193,241,125-193,300,939
(GRCh38/hg38)
Size:
59,815 bases
Orientation:
Plus strand
chr3:192,958,914-192,995,527
(GRCh37/hg19)

Genomic View for HRASLS Gene

Genes around HRASLS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HRASLS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HRASLS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HRASLS Gene

Proteins for HRASLS Gene

  • Protein details for HRASLS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HDD0-HRSL1_HUMAN
    Recommended name:
    Phospholipid-metabolizing enzyme A-C1
    Protein Accession:
    Q9HDD0
    Secondary Accessions:
    • D2KX19

    Protein attributes for HRASLS Gene

    Size:
    168 amino acids
    Molecular mass:
    18750 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HRASLS Gene

Post-translational modifications for HRASLS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HRASLS Gene

No data available for DME Specific Peptides for HRASLS Gene

Domains & Families for HRASLS Gene

Gene Families for HRASLS Gene

Protein Domains for HRASLS Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for HRASLS Gene

Graphical View of Domain Structure for InterPro Entry

Q9HDD0

UniProtKB/Swiss-Prot:

HRSL1_HUMAN :
  • Belongs to the H-rev107 family.
Family:
  • Belongs to the H-rev107 family.
genes like me logo Genes that share domains with HRASLS: view

Function for HRASLS Gene

Molecular function for HRASLS Gene

UniProtKB/Swiss-Prot Function:
Exhibits calcium-independent phospholipase activity towards phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Also shows acyltransferase activities, transferring an acyl group of PCs to the amino group of PEs and the hydroxyl group of lyso PCs.

Enzyme Numbers (IUBMB) for HRASLS Gene

Gene Ontology (GO) - Molecular Function for HRASLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016740 transferase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with HRASLS: view
genes like me logo Genes that share phenotypes with HRASLS: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HRASLS Gene

Localization for HRASLS Gene

Subcellular locations from UniProtKB/Swiss-Prot for HRASLS Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HRASLS gene
Compartment Confidence
cytosol 3
peroxisome 2
plasma membrane 1
mitochondrion 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Focal adhesion sites (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HRASLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HRASLS: view

Pathways & Interactions for HRASLS Gene

genes like me logo Genes that share pathways with HRASLS: view

Interacting Proteins for HRASLS Gene

Selected Interacting proteins: Q9HDD0-HRSL1_HUMAN for HRASLS Gene via IID

Symbol External ID(s) Details
APP

Gene Ontology (GO) - Biological Process for HRASLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016042 lipid catabolic process IEA --
genes like me logo Genes that share ontologies with HRASLS: view

No data available for SIGNOR curated interactions for HRASLS Gene

Drugs & Compounds for HRASLS Gene

No Compound Related Data Available

Transcripts for HRASLS Gene

Unigene Clusters for HRASLS Gene

HRAS-like suppressor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for HRASLS Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
SP1:
SP2:

Relevant External Links for HRASLS Gene

GeneLoc Exon Structure for
HRASLS
ECgene alternative splicing isoforms for
HRASLS

Expression for HRASLS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HRASLS Gene

mRNA differential expression in normal tissues according to GTEx for HRASLS Gene

This gene is overexpressed in Testis (x17.0) and Muscle - Skeletal (x7.8).

NURSA nuclear receptor signaling pathways regulating expression of HRASLS Gene:

HRASLS

SOURCE GeneReport for Unigene cluster for HRASLS Gene:

Hs.36761

mRNA Expression by UniProt/SwissProt for HRASLS Gene:

Q9HDD0-HRSL1_HUMAN
Tissue specificity: Abundantly expressed in testis, skeletal muscle, brain, and heart.
genes like me logo Genes that share expression patterns with HRASLS: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HRASLS Gene

Orthologs for HRASLS Gene

This gene was present in the common ancestor of chordates.

Orthologs for HRASLS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HRASLS 33 34
  • 99.15 (n)
dog
(Canis familiaris)
Mammalia HRASLS 33 34
  • 88.29 (n)
rat
(Rattus norvegicus)
Mammalia Hrasls 33
  • 85.54 (n)
cow
(Bos Taurus)
Mammalia HRASLS 33 34
  • 84.4 (n)
mouse
(Mus musculus)
Mammalia Hrasls 33 16 34
  • 83.83 (n)
oppossum
(Monodelphis domestica)
Mammalia HRASLS 34
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves HRASLS 33 34
  • 69.64 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 41 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia hrasls 33
  • 68.9 (n)
zebrafish
(Danio rerio)
Actinopterygii hrasls 33 34
  • 62.24 (n)
Dr.19593 33
Species where no ortholog for HRASLS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HRASLS Gene

ENSEMBL:
Gene Tree for HRASLS (if available)
TreeFam:
Gene Tree for HRASLS (if available)

Paralogs for HRASLS Gene

Paralogs for HRASLS Gene

(4) SIMAP similar genes for HRASLS Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HRASLS: view

Variants for HRASLS Gene

Sequence variations from dbSNP and Humsavar for HRASLS Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000070347 -- 193,254,468(+) TCAAC(A/T)TAGAT intron-variant
rs1000096110 -- 193,277,584(+) CACCC(C/G)TATGC intron-variant
rs1000185179 -- 193,272,561(+) AGGAT(A/G)CCTAC intron-variant
rs1000219075 -- 193,269,786(+) AGGCA(A/G)TATTA intron-variant
rs1000245884 -- 193,239,286(+) CAGCA(A/T)CAGAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HRASLS Gene

Variant ID Type Subtype PubMed ID
nsv428429 CNV gain 18775914
nsv1003505 CNV gain 25217958
esv3599181 CNV loss 21293372
esv3563119 CNV deletion 23714750
esv3377368 CNV insertion 20981092
esv2759211 CNV gain 17122850
esv2660978 CNV deletion 23128226

Variation tolerance for HRASLS Gene

Residual Variation Intolerance Score: 69.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.94; 36.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HRASLS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HRASLS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HRASLS Gene

Disorders for HRASLS Gene

MalaCards: The human disease database

(1) MalaCards diseases for HRASLS Gene - From: Novoseek

Disorder Aliases PubMed IDs
gastric cancer, somatic
  • gastric cancer
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HRASLS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HRASLS
genes like me logo Genes that share disorders with HRASLS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HRASLS Gene

Publications for HRASLS Gene

  1. Enzymological analysis of the tumor suppressor A-C1 reveals a novel group of phospholipid-metabolizing enzymes. (PMID: 21880860) Shinohara N … Ueda N (Journal of lipid research 2011) 3 4 60
  2. Isolation, characterization, and chromosome mapping of a human A-C1 Ha-Ras suppressor gene (HRASLS). (PMID: 11474175) Ito H … Nakamura T (Cytogenetics and cell genetics 2001) 3 22 60
  3. Molecular interaction between K-Ras and H-REV107 in the Ras signaling pathway. (PMID: 28743497) Han CW … Jang SB (Biochemical and biophysical research communications 2017) 3 60
  4. The HRASLS (PLA/AT) subfamily of enzymes. (PMID: 26503625) Mardian EB … Duncan RE (Journal of biomedical science 2015) 3 60
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 60

Products for HRASLS Gene

Sources for HRASLS Gene

Content
Loading form....