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Aliases for HRASLS Gene

Aliases for HRASLS Gene

  • HRAS-Like Suppressor 2 3
  • HRAS-Like Suppressor 1 3 4
  • HRSL1 3 4
  • Phospholipid-Metabolizing Enzyme A-C1 3
  • H-REV107 Protein-Related Protein 3
  • Phospholipase A 3
  • EC 2.3.1.- 4
  • EC 3.1.1.- 4
  • H-REV107 3
  • HRASLS1 3
  • HSD28 3
  • A-C1 3

External Ids for HRASLS Gene

Summaries for HRASLS Gene

GeneCards Summary for HRASLS Gene

HRASLS (HRAS-Like Suppressor) is a Protein Coding gene. GO annotations related to this gene include transferase activity and phospholipase activity. An important paralog of this gene is RARRES3.

UniProtKB/Swiss-Prot for HRASLS Gene

  • Exhibits calcium-independent phospholipase activity towards phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Also shows acyltransferase activities, transferring an acyl group of PCs to the amino group of PEs and the hydroxyl group of lyso PCs.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HRASLS Gene

Genomics for HRASLS Gene

Genomic Location for HRASLS Gene

Start:
193,230,241 bp from pter
End:
193,307,315 bp from pter
Size:
77,075 bases
Orientation:
Plus strand

Genomic View for HRASLS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HRASLS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HRASLS Gene

Regulatory Elements for HRASLS Gene

Proteins for HRASLS Gene

  • Protein details for HRASLS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HDD0-HRSL1_HUMAN
    Recommended name:
    Phospholipid-metabolizing enzyme A-C1
    Protein Accession:
    Q9HDD0
    Secondary Accessions:
    • D2KX19

    Protein attributes for HRASLS Gene

    Size:
    168 amino acids
    Molecular mass:
    18750 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HRASLS Gene

Proteomics data for HRASLS Gene at MOPED

Post-translational modifications for HRASLS Gene

No Post-translational modifications

Other Protein References for HRASLS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HRASLS Gene

Domains for HRASLS Gene

Protein Domains for HRASLS Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

HRSL1_HUMAN
Family:
  • Belongs to the H-rev107 family.:
    • Q9HDD0
genes like me logo Genes that share domains with HRASLS: view

No data available for Gene Families for HRASLS Gene

Function for HRASLS Gene

Molecular function for HRASLS Gene

UniProtKB/Swiss-Prot Function: Exhibits calcium-independent phospholipase activity towards phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Also shows acyltransferase activities, transferring an acyl group of PCs to the amino group of PEs and the hydroxyl group of lyso PCs.

Enzyme Numbers (IUBMB) for HRASLS Gene

Gene Ontology (GO) - Molecular Function for HRASLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004620 phospholipase activity --
GO:0016740 transferase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with HRASLS: view

Phenotypes for HRASLS Gene

GenomeRNAi human phenotypes for HRASLS:
genes like me logo Genes that share phenotypes with HRASLS: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HRASLS Gene

Localization for HRASLS Gene

Subcellular locations from UniProtKB/Swiss-Prot for HRASLS Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HRASLS Gene COMPARTMENTS Subcellular localization image for HRASLS gene
Compartment Confidence
cytosol 2
nucleus 2
peroxisome 2
golgi apparatus 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HRASLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005641 nuclear envelope lumen --
GO:0005737 cytoplasm --
GO:0005777 peroxisome --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HRASLS: view

Pathways for HRASLS Gene

SuperPathways for HRASLS Gene

No Data Available

Interacting Proteins for HRASLS Gene

Gene Ontology (GO) - Biological Process for HRASLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007031 peroxisome organization --
GO:0016042 lipid catabolic process IEA --
GO:0046485 ether lipid metabolic process --
genes like me logo Genes that share ontologies with HRASLS: view

No data available for Pathways by source for HRASLS Gene

Transcripts for HRASLS Gene

Unigene Clusters for HRASLS Gene

HRAS-like suppressor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HRASLS Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
SP1:
SP2:

Relevant External Links for HRASLS Gene

GeneLoc Exon Structure for
HRASLS
ECgene alternative splicing isoforms for
HRASLS

Expression for HRASLS Gene

mRNA expression in normal human tissues for HRASLS Gene

mRNA differential expression in normal tissues according to GTEx for HRASLS Gene

This gene is overexpressed in Testis (17.0) and Muscle - Skeletal (7.8).

SOURCE GeneReport for Unigene cluster for HRASLS Gene Hs.36761

mRNA Expression by UniProt/SwissProt for HRASLS Gene

Q9HDD0-HRSL1_HUMAN
Tissue specificity: Abundantly expressed in testis, skeletal muscle, brain, and heart.
genes like me logo Genes that share expressions with HRASLS: view

Orthologs for HRASLS Gene

This gene was present in the common ancestor of chordates.

Orthologs for HRASLS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HRASLS 36
  • 99.15 (n)
  • 98.9 (a)
HRASLS 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HRASLS 36
  • 84.4 (n)
  • 85.82 (a)
HRASLS 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HRASLS 36
  • 88.29 (n)
  • 84.52 (a)
HRASLS 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hrasls 36
  • 83.83 (n)
  • 84.43 (a)
Hrasls 16
Hrasls 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HRASLS 37
  • 47 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hrasls 36
  • 85.54 (n)
  • 84.34 (a)
chicken
(Gallus gallus)
Aves HRASLS 36
  • 69.64 (n)
  • 73.21 (a)
HRASLS 37
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 41 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia hrasls 36
  • 68.9 (n)
  • 68.29 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.19593 36
hrasls 36
  • 62.24 (n)
  • 61.27 (a)
hrasls 37
  • 58 (a)
OneToOne
Species with no ortholog for HRASLS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HRASLS Gene

ENSEMBL:
Gene Tree for HRASLS (if available)
TreeFam:
Gene Tree for HRASLS (if available)

Paralogs for HRASLS Gene

Paralogs for HRASLS Gene

Selected SIMAP similar genes for HRASLS Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HRASLS: view

Variants for HRASLS Gene

Sequence variations from dbSNP and Humsavar for HRASLS Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1320154 -- 193,256,803(-) CCTTA(C/T)ACAGA intron-variant
rs1462483 -- 193,236,876(-) TCTTG(A/G)ATGTT intron-variant
rs1580280 -- 193,247,846(-) atatg(A/G)tatat intron-variant
rs1841758 -- 193,246,642(-) gctca(C/T)gcttg intron-variant
rs2276723 -- 193,230,397(-) TACTG(C/T)ATCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HRASLS Gene

Variant ID Type Subtype PubMed ID
dgv1546e1 CNV Complex 17122850
nsv428429 CNV Gain 18775914
nsv878123 CNV Gain 21882294
esv2660978 CNV Deletion 23128226

Relevant External Links for HRASLS Gene

HapMap Linkage Disequilibrium report
HRASLS

Disorders for HRASLS Gene

(2) Novoseek inferred disease relationships for HRASLS Gene

Disease -log(P) Hits PubMed IDs
gastric cancer 54.2 6
tumors 8.26 1
genes like me logo Genes that share disorders with HRASLS: view

No data available for UniProtKB/Swiss-Prot for HRASLS Gene

Publications for HRASLS Gene

  1. Isolation, characterization, and chromosome mapping of a human A-C1 Ha-Ras suppressor gene (HRASLS). (PMID: 11474175) Ito H. … Nakamura T. (Cytogenet. Cell Genet. 2001) 3 23
  2. Enzymological analysis of the tumor suppressor A-C1 reveals a novel group of phospholipid-metabolizing enzymes. (PMID: 21880860) Shinohara N. … Ueda N. (J. Lipid Res. 2011) 3 4
  3. Identification of silencing of nine genes in human gastric cancers. (PMID: 12438262) Kaneda A. … Ushijima T. (Cancer Res. 2002) 23
  4. Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers. (PMID: 15374948) Kaneda A. … Ushijima T. (Cancer Res. 2004) 23
  5. CpG island promoter hypermethylation of the Ras-effector gene NORE1A occurs in the context of a wild-type K-ras in lung cancer. (PMID: 15378027) Irimia M. … Esteller M. (Oncogene 2004) 23

Products for HRASLS Gene

Sources for HRASLS Gene

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