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HRASLS Gene

protein-coding   GIFtS: 47
GCID: GC03P192958

HRAS-Like Suppressor

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
HRAS-Like Suppressor1 2     HSD282
HRSL12 3     H-REV107 Protein-Related Protein2
HRAS-Like Suppressor 12 3     Phospholipase A2
A-C12     Phospholipid-Metabolizing Enzyme A-C12
H-REV1072     EC 2.3.1.-3
HRASLS12     EC 3.1.1.-3

External Ids:    HGNC: 149221   Entrez Gene: 571102   Ensembl: ENSG000001272527   OMIM: 6064875   UniProtKB: Q9HDD03   

Export aliases for HRASLS gene to outside databases

Previous GC identifers: GC03P190025 GC03P194220 GC03P194360 GC03P194279 GC03P194441 GC03P190346


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HRASLS Gene:
HRASLS (HRAS-like suppressor) is a protein-coding gene. Diseases associated with HRASLS include cervical cancer, and cervicitis. GO annotations related to this gene include phospholipase activity and transferase activity. An important paralog of this gene is PLA2G16.

UniProtKB/Swiss-Prot: HRSL1_HUMAN, Q9HDD0
Function: Exhibits calcium-independent phospholipase activity towards phosphatidylcholine (PC) and
phosphatidylethanolamine (PE). Also shows acyltransferase activities, transferring an acyl group of PCs to the
amino group of PEs and the hydroxyl group of lyso PCs




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HRASLS gene promoter:
         MEF-2A   TBP   AREB6   Tal-1   MEF-2   TFIID   HTF   HSF2   aMEF-2   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHRASLS promoter sequence
   Search Chromatin IP Primers for HRASLS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HRASLS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q29   Ensembl cytogenetic band:  3q29   HGNC cytogenetic band: 3q29

HRASLS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HRASLS gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P192958:  view genomic region     (about GC identifiers)

Start:
192,958,914 bp from pter      End:
192,995,527 bp from pter
Size:
36,614 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HRSL1_HUMAN, Q9HDD0 (See protein sequence)
Recommended Name: Phospholipid-metabolizing enzyme A-C1  
Size: 168 amino acids; 18750 Da
Secondary accessions: D2KX19

Explore the universe of human proteins at neXtProt for HRASLS: NX_Q9HDD0

Explore proteomics data for HRASLS at MOPED


See HRASLS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_065119.2  
ENSEMBL proteins: 
 ENSP00000264735   ENSP00000414431   ENSP00000473258  

HRASLS Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR007053 LRAT-like_dom

Graphical View of Domain Structure for InterPro Entry Q9HDD0

ProtoNet protein and cluster: Q9HDD0

1 Blocks protein domain: IPB007053 NC

UniProtKB/Swiss-Prot: HRSL1_HUMAN, Q9HDD0
Similarity: Belongs to the H-rev107 family


HRASLS for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: HRSL1_HUMAN, Q9HDD0
Function: Exhibits calcium-independent phospholipase activity towards phosphatidylcholine (PC) and
phosphatidylethanolamine (PE). Also shows acyltransferase activities, transferring an acyl group of PCs to the
amino group of PEs and the hydroxyl group of lyso PCs

     Enzyme Numbers (IUBMB): EC 3.1.1.-1 EC 2.3.1.-1

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004620phospholipase activity ----
GO:0016740transferase activity IEA--
GO:0016787hydrolase activity IEA--
     
HRASLS for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for HRASLS:
 Decreased melanin production 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HRASLS
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miRNA
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1 qRT-PCR Assays for microRNA that regulate HRASLS:
hsa-miR-3647-3p
SwitchGear 3'UTR luciferase reporter plasmidHRASLS 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat HRASLS

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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HRASLS

Cell Line
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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
HRSL1_HUMAN, Q9HDD0: Membrane; Single-pass membrane protein (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol2
nucleus2
peroxisome2
golgi apparatus1
mitochondrion1
plasma membrane1

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005641nuclear envelope lumen ----
GO:0005737cytoplasm ----
GO:0005777peroxisome ----
GO:0016021integral component of membrane IEA--

HRASLS for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HRASLS
Interactions:

    Search GeneGlobe Interaction Network for HRASLS

Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007031peroxisome organization ----
GO:0016042lipid catabolic process IEA--
GO:0046485ether lipid metabolic process ----

HRASLS for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for HRASLS (HRSL1)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for HRASLS gene: 
NM_020386.4  

Unigene Cluster for HRASLS:

HRAS-like suppressor
Hs.36761  [show with all ESTs]
Unigene Representative Sequence: BC048095
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000264735(uc003fta.3) ENST00000416012 ENST00000602513
miRNA
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1 qRT-PCR Assays for microRNA that regulate HRASLS:
hsa-miR-3647-3p
SwitchGear 3'UTR luciferase reporter plasmidHRASLS 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for HRASLS
Predesigned siRNA for gene silencing in human, mouse, rat HRASLS
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OriGene ORF clones in mouse, rat for HRASLS
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: HRASLS (NM_017878)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HRASLS
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HRASLS
Primer
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OriGene qPCR primer pairs and template standards for HRASLS
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HRASLS
  QuantiTect SYBR Green Assays in human, mouse, rat HRASLS
  QuantiFast Probe-based Assays in human, mouse, rat HRASLS

Additional mRNA sequence: 

AB030816.1 AB510981.1 AY251533.1 BC048095.1 

3 DOTS entries:

DT.213305  DT.120860918  DT.95318370 

Selected AceView cDNA sequences (see all 32):

AB030816 BU541990 BM692792 BM671352 NM_020386 F32781 AI018579 AA404482 
AY251533 AI989666 BG717629 AI703120 BC048095 AI148017 AA608560 AI805320 
AI039534 AA496125 BF061734 AI159761 BG718302 AI824880 AA496124 BE671858 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for HRASLS    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
SP1:                              
SP2:                              


ECgene alternative splicing isoforms for HRASLS

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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HRASLS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GTCAGAGCCT
HRASLS Expression
About this image


HRASLS expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 4) fully expand
 
 Brain (Nervous System)    fully expand to see all 18 entries
         Thalamus
         Septum   
 
 Testis (Reproductive System)    fully expand to see all 3 entries
         Leydig Cells Testis Interstitium
         Testis Interstitium
 
 Endothelium (Cardiovascular System)
         Human umbilical vein endothelial cells (HUVEC)
 
 Ovary (Reproductive System)
HRASLS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

HRASLS Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.36761

UniProtKB/Swiss-Prot: HRSL1_HUMAN, Q9HDD0
Tissue specificity: Abundantly expressed in testis, skeletal muscle, brain, and heart

    Custom PCR Arrays for HRASLS
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QuantiFast Probe-based Assays in human, mouse, rat HRASLS
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRASLS

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for HRASLS gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Hrasls1 , 5 HRAS-like suppressor1, 5 83.83(n)1
84.43(a)1
  16 (20.01 cM)5
272811  NM_013751.51  NP_038779.21 
 292096955 
chicken
(Gallus gallus)
Aves HRASLS1 HRAS-like suppressor 69.64(n)
73.21(a)
  424903  XM_004943333.1  XP_004943390.1 
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
41(a)
many ↔ many
GL343890.1(32031-40740)
tropical clawed frog
(Xenopus tropicalis)
Amphibia hrasls1 HRAS-like suppressor 68.9(n)
68.29(a)
  100379919  XM_002936879.2  XP_002936925.1 
zebrafish
(Danio rerio)
Actinopterygii Dr.195932 Transcribed sequence with weak similarity to protein more 74.49(n)    CK355737.1 


ENSEMBL Gene Tree for HRASLS (if available)
TreeFam Gene Tree for HRASLS (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for HRASLS gene
PLA2G162  HRASLS22  RARRES32  HRASLS52  
4 SIMAP similar genes for HRASLS using alignment to 3 protein entries:     HRSL1_HUMAN (see all proteins):
HRASLS2    PLA2G16    HRASLS5    RARRES3

HRASLS for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for HRASLS (see all 599)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs607171201,2
C--192838474(+) TTTTT-/CTGGCCA 1 -- int11Minor allele frequency- CT:0.00NA 2
rs1502159781,2
C--192957055(+) ACTCTC/TACTAT 1 -- us2k10--------
rs1388116911,2
--192957070(+) TTAGGC/TAGCAA 1 -- us2k10--------
rs745790711,2
C,F--192957089(+) GCCAGC/ACACAC 1 -- us2k11Minor allele frequency- A:0.04WA 118
rs1824398701,2
--192957165(+) CCAATC/GATAGC 1 -- us2k10--------
rs1879654741,2
--192957208(+) TGCCTA/GTTACT 1 -- us2k10--------
rs1924427451,2
--192957272(+) TCATCC/TGTAGA 1 -- us2k10--------
rs1494972991,2
C--192957352(+) TACAAC/TGCTTT 1 -- us2k10--------
rs794883081,2
--192957431(+) TATACC/GTGGCA 1 -- us2k10--------
rs1153100761,2
F--192962262(+) GTTTTT/GTTTTT 1 -- int11Minor allele frequency- G:0.02WA 118

HapMap Linkage Disequilibrium report for HRASLS (192958914 - 192995527 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for HRASLS:    About this table    
Variant IDTypeSubtypePubMed ID
esv2660978CNV Deletion23128226
nsv428429CNV Gain18775914
nsv878123CNV Gain21882294
dgv1546e1CNV Complex17122850

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing HRASLS
DNA2.0 Custom Variant and Variant Library Synthesis for HRASLS

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 606487    OMIM disorders: --

4 diseases for HRASLS:    
About MalaCards
cervical cancer    cervicitis    lung cancer    cerebritis


HRASLS for disorders           About GeneDecksing

2 Novoseek inferred disease relationships for HRASLS gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
gastric cancer 54.2 6 15374948 (3), 12438262 (2), 16707594 (1)
tumors 8.26 1 15374948 (1)


Export disorders for HRASLS gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for HRASLS gene, integrated from 10 sources (see all 14):
(articles sorted by number of sources associating them with HRASLS)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Enzymological analysis of the tumor suppressor A-C1 reveals a novel group of phospholipid-metabolizing enzymes. (PubMed id 21880860)1, 2 Shinohara N....Ueda N. (J. Lipid Res. 2011)
  2. Isolation, characterization, and chromosome mapping of a human A-C1 Ha-Ras suppressor gene (HRASLS). (PubMed id 11474175)1, 9 Ito H....Nakamura T. (Cytogenet. Cell Genet. 2001)
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
  4. Solution structure of the N-terminal catalytic domain of human H- REV107 -- a novel circular permutated NlpC/P60 domain. (PubMed id 20837014)1 Ren X.... Xia B. (FEBS Lett. 2010)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  6. Molecular cloning and biological activity of a novel Ha-Ras suppressor gene predominantly expressed in skeletal muscle, heart, brain, and bone marrow by differential display using clonal mouse EC cells, ATDC5. (PubMed id 10542256)1 Akiyama H....Nakamura T. (J. Biol. Chem. 1999)
  7. Transcriptional and translational downregulation of H-REV107, a class II tumour suppressor gene located on human chromosome 11q11-12. (PubMed id 9771974)1 Husmann K.... Schafer R. (Oncogene 1998)
  8. (PubMed id )2 
  9. Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers. (PubMed id 15374948)9 Kaneda A....Ushijima T. (Cancer Res. 2004)
  10. CpG island promoter hypermethylation of the Ras-effector gene NORE1A occurs in the context of a wild-type K-ras in lung cancer. (PubMed id 15378027)9 Irimia M....Esteller M. (Oncogene 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 57110 HGNC: 14922 AceView: HRASLS Ensembl:ENSG00000127252 euGenes: HUgn57110
ECgene: HRASLS H-InvDB: HRASLS

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for HRASLS Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for HRASLS Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for HRASLS gene:
Search GeneIP for patents involving HRASLS

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 EMD Millipore genomic analysis products

  
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 OriGene Antibodies for HRASLS   OriGene RNAi products in human, mouse, rat for HRASLS  
 OriGene qPCR primer pairs and template standards for HRASLS   Browse OriGene Protein Over-expression Lysates  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for HRASLS  
 OriGene qSTAR qPCR primer pairs in human, mouse for HRASLS   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for HRASLS   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for HRASLS   OriGene Custom Protein Services for HRASLS  

 
 
 Block miRNA regulation of human, mouse, rat HRASLS using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HRASLS
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HRASLS Predesigned siRNA for gene silencing in human, mouse, rat HRASLS
 QuantiFast Probe-based Assays in human, mouse, rat HRASLS QuantiTect SYBR Green Assays in human, mouse, rat HRASLS
 Custom PCR Arrays for HRASLS Search Chromatin IP Primers for HRASLS
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HRASLS  Search GeneGlobe Interaction Network for HRASLS
 Regulatory tfbs in HRASLS promoter
 GenScript Custom Purified and Recombinant Proteins Services for HRASLS GenScript cDNA clones with any tag delivered in your preferred vector for HRASLS
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 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
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 Search Tocris compounds for HRASLS (HRSL1)
 Browse Sino Biological Proteins
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 HRASLS antibodies
 HRASLS proteins
 HRASLS lysates
 Antibodies for HRASLS
 See all of Abcam's Antibodies, Kits and Proteins for HRASLS
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 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for HRASLS
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 Browse ESI BIO Cell Lines and PureStem Progenitors for HRASLS
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRASLS
 SwitchGear 3'UTR luciferase reporter plasmids for HRASLS
 SwitchGear Promoter luciferase reporter plasmids for HRASLS
 ThermoFisher Antibodies for HRASLS
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HRASLS
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HRASLS
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HRASLS
 LSBio Antibodies in human, mouse, rat for HRASLS
Customized transgenic rodents for:
 Humanization
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 Tissue-specific gene expresssion
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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