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Aliases for HRAS Gene

Aliases for HRAS Gene

  • HRas Proto-Oncogene, GTPase 2 3 5
  • V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog 2 3
  • Harvey Rat Sarcoma Viral Oncogene Homolog 2 3
  • Transforming Protein P21 3 4
  • C-H-RAS 3 4
  • P21ras 3 4
  • HRAS1 3 4
  • Ras Family Small GTP Binding Protein H-Ras 3
  • Harvey Rat Sarcoma Viral Oncoprotein 3
  • Transformation Gene: Oncogene HAMSV 3
  • GTP- And GDP-Binding Peptide B 3
  • C-Ras-Ki-2 Activated Oncogene 3
  • Ha-Ras1 Proto-Oncoprotein 3
  • C-Has/Bas P21 Protein 3
  • P19 H-RasIDX Protein 3
  • GTPase HRas 3
  • C-BAS/HAS 3
  • C-HA-RAS1 3
  • H-RASIDX 3
  • H-Ras-1 4
  • Ha-Ras 4
  • HAMSV 3
  • RASH1 3
  • CTLO 3

External Ids for HRAS Gene

Previous HGNC Symbols for HRAS Gene

  • HRAS1

Previous GeneCards Identifiers for HRAS Gene

  • GC11P001100
  • GC11P001123
  • GC11P000664
  • GC11M000346

Summaries for HRAS Gene

Entrez Gene Summary for HRAS Gene

  • This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008]

CIViC summary for HRAS Gene

GeneCards Summary for HRAS Gene

HRAS (HRas Proto-Oncogene, GTPase) is a Protein Coding gene. Diseases associated with HRAS include Costello Syndrome and Nevus, Epidermal. Among its related pathways are RET signaling and Development EGFR signaling via small GTPases. Gene Ontology (GO) annotations related to this gene include GTP binding and protein C-terminus binding. An important paralog of this gene is KRAS.

UniProtKB/Swiss-Prot for HRAS Gene

  • Involved in the activation of Ras protein signal transduction (PubMed:22821884). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:12740440, PubMed:14500341, PubMed:9020151).

Gene Wiki entry for HRAS Gene

Additional gene information for HRAS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HRAS Gene

Genomics for HRAS Gene

GeneHancer (GH) Regulatory Elements for HRAS Gene

Promoters and enhancers for HRAS Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I000534 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 567.8 +1.0 998 4.3 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ARID4B SIN3A ZBTB7B POLR2B LRRC56 HRAS TMEM80 RNH1 PIDD1 DRD4 PHRF1 GATD1 ENSG00000255142 ENSG00000255158
GH11I000443 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 11.3 +89.5 89541 8.2 MLX ZFP64 DMAP1 IRF4 YY1 ZNF213 ZNF143 ZNF548 SP3 NFYC PTDSS2 RNH1 LRRC56 TSPAN4 SNORA52 PHRF1 ENSG00000255237 ANO9 HRAS BET1L
GH11I000559 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 12.5 -25.6 -25628 7.5 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B FOS LMNTD2 GC11M000563 RASSF7 PHRF1 HRAS TMEM80 PKP3 RNH1 PTDSS2 LOC692247
GH11I000611 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 12 -77.0 -77029 5.4 HDGF PKNOX1 ATF1 SIN3A IRF4 YY1 POLR2B ZNF207 ZNF143 ATF7 IRF7 HRAS TMEM80 RNH1 LRRC56 GC11P000616 CDHR5 PIR42218 PHRF1
GH11I000574 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 9.8 -41.1 -41094 6.9 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 PHRF1 TMEM80 SNORA52 ENSG00000255237 BET1L TSPAN4 PSMD13 RIC8A RPLP2 HRAS
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HRAS on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HRAS gene promoter:

Genomic Locations for HRAS Gene

Genomic Locations for HRAS Gene
chr11:532,242-537,287
(GRCh38/hg38)
Size:
5,046 bases
Orientation:
Minus strand
chr11:532,242-537,287
(GRCh37/hg19)

Genomic View for HRAS Gene

Genes around HRAS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HRAS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HRAS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HRAS Gene

Proteins for HRAS Gene

  • Protein details for HRAS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01112-RASH_HUMAN
    Recommended name:
    GTPase HRas
    Protein Accession:
    P01112
    Secondary Accessions:
    • B5BUA0
    • Q14080
    • Q6FHV9
    • Q9BR65
    • Q9UCE2

    Protein attributes for HRAS Gene

    Size:
    189 amino acids
    Molecular mass:
    21298 Da
    Quaternary structure:
    • In its GTP-bound form interacts with PLCE1 (PubMed:11022048). Interacts with TBC1D10C (PubMed:17230191). Interacts with RGL3 (By similarity). Interacts with HSPD1 (By similarity). Found in a complex with at least BRAF, HRAS, MAP2K1, MAPK3 and RGS14 (By similarity). Interacts (active GTP-bound form) with RGS14 (via RBD 1 domain) (By similarity). Forms a signaling complex with RASGRP1 and DGKZ (PubMed:11257115). Interacts with RASSF5 (PubMed:18596699). Interacts with PDE6D (PubMed:11980706). Interacts with IKZF3 (PubMed:10369681). Interacts with RACK1 (PubMed:14500341). Interacts with PIK3CG; the interaction is required for membrane recruitment and beta-gamma G protein dimer-dependent activation of the PI3K gamma complex PIK3CG:PIK3R6 (By similarity). Interacts with RAPGEF2 (PubMed:10608844, PubMed:11598133).

    Three dimensional structures from OCA and Proteopedia for HRAS Gene

    Alternative splice isoforms for HRAS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HRAS Gene

Post-translational modifications for HRAS Gene

  • Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs).
  • Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.
  • S-nitrosylated; critical for redox regulation. Important for stimulating guanine nucleotide exchange. No structural perturbation on nitrosylation.
  • The covalent modification of cysteine by 15-deoxy-Delta12,14-prostaglandin-J2 is autocatalytic and reversible. It may occur as an alternative to other cysteine modifications, such as S-nitrosylation and S-palmitoylation.

No data available for DME Specific Peptides for HRAS Gene

Domains & Families for HRAS Gene

Gene Families for HRAS Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for HRAS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01112

UniProtKB/Swiss-Prot:

RASH_HUMAN :
  • Belongs to the small GTPase superfamily. Ras family.
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with HRAS: view

Function for HRAS Gene

Molecular function for HRAS Gene

GENATLAS Biochemistry:
Harvey rat sarcoma viral (v-Ha-ras1) oncogene homolog
UniProtKB/Swiss-Prot EnzymeRegulation:
Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).
UniProtKB/Swiss-Prot Function:
Involved in the activation of Ras protein signal transduction (PubMed:22821884). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:12740440, PubMed:14500341, PubMed:9020151).

Phenotypes From GWAS Catalog for HRAS Gene

Gene Ontology (GO) - Molecular Function for HRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IMP,IDA 9230043
GO:0005515 protein binding IPI 2122974
GO:0005525 GTP binding IMP 9230043
GO:0008022 protein C-terminus binding IPI 9219684
genes like me logo Genes that share ontologies with HRAS: view
genes like me logo Genes that share phenotypes with HRAS: view

Human Phenotype Ontology for HRAS Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for HRAS Gene

MGI Knock Outs for HRAS:

Animal Model Products

Clone Products

  • Addgene plasmids for HRAS

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for HRAS Gene

Localization for HRAS Gene

Subcellular locations from UniProtKB/Swiss-Prot for HRAS Gene

Cell membrane. Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Golgi apparatus membrane; Lipid-anchor. Note=The active GTP-bound form is localized most strongly to membranes than the inactive GDP-bound form (By similarity). Shuttles between the plasma membrane and the Golgi apparatus. {ECO:0000250}.
Isoform 2: Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Colocalizes with RACK1 to the perinuclear region.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HRAS gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
golgi apparatus 5
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
lysosome 2
endosome 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for HRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm TAS 10842192
GO:0005794 Golgi apparatus IDA,IEA 14500341
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with HRAS: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HRAS Gene

Pathways & Interactions for HRAS Gene

SuperPathway Contained pathways
1 RET signaling
2 Downstream signaling of activated FGFR2
3 IL-2 Pathway
4 Endometrial cancer
.52
.47
5 Regulation of lipid metabolism Insulin signaling-generic cascades
genes like me logo Genes that share pathways with HRAS: view

Pathways by source for HRAS Gene

SIGNOR curated interactions for HRAS Gene

Gene Ontology (GO) - Biological Process for HRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0001934 positive regulation of protein phosphorylation IDA 22065586
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006897 endocytosis IEA --
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with HRAS: view

Drugs & Compounds for HRAS Gene

(76) Drugs for HRAS Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fludarabine Approved Pharma DNA synthsis inhibitor 1231,1231
Dabrafenib Approved, Investigational Pharma BRAF kinase inhibitor, Kinase Inhibitors, Mutant BRAF Kinase 92
Aldesleukin Approved Pharma 419
Cyclophosphamide Approved, Investigational Pharma Nitrogen mustard alkylating agent and prodrug. 3113
Guanosine diphosphate Experimental Pharma Target 0

(43) Additional Compounds for HRAS Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(3) ApexBio Compounds for HRAS Gene

Compound Action Cas Number
Kobe0065 Ras inhibitor 436133-68-5
kobe2602 Ras inhibitor 454453-49-7
Salirasib Inhibitor of active Ras protein 162520-00-5
genes like me logo Genes that share compounds with HRAS: view

Drug Products

Transcripts for HRAS Gene

Unigene Clusters for HRAS Gene

V-Ha-ras Harvey rat sarcoma viral oncogene homolog:
Representative Sequences:

Clone Products

  • Addgene plasmids for HRAS

Alternative Splicing Database (ASD) splice patterns (SP) for HRAS Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c
SP1:
SP2: -
SP3:
SP4: -
SP5: - - -
SP6: - - -

Relevant External Links for HRAS Gene

GeneLoc Exon Structure for
HRAS
ECgene alternative splicing isoforms for
HRAS

Expression for HRAS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HRAS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HRAS Gene

This gene is overexpressed in Brain (8.5), Bone (8.0), Peripheral blood mononuclear cells (7.3), Monocytes (6.9), and Fetal Brain (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HRAS Gene



NURSA nuclear receptor signaling pathways regulating expression of HRAS Gene:

HRAS

SOURCE GeneReport for Unigene cluster for HRAS Gene:

Hs.37003

mRNA Expression by UniProt/SwissProt for HRAS Gene:

P01112-RASH_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for HRAS Gene

  • Nervous system(4.6)
  • Intestine(3.7)
  • Lung(3.6)
  • Skin(3.6)
  • Blood(3.1)
  • Pancreas(3.1)
  • Liver(3)
  • Lymph node(3)
  • Thyroid gland(2.9)
  • Kidney(2.8)
  • Bone marrow(2.7)
  • Gall bladder(2.7)
  • Heart(2.7)
  • Muscle(2.7)
  • Stomach(2.5)
  • Adrenal gland(2.4)
  • Spleen(2.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for HRAS Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Organs:
Head and neck:
  • brain
  • cerebellum
  • cerebrospinal fluid
  • cheek
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • inner ear
  • jaw
  • larynx
  • lip
  • mandible
  • maxilla
  • meninges
  • mouth
  • neck
  • nose
  • outer ear
  • scalp
  • skull
  • thyroid
  • tongue
  • tooth
  • vocal cord
Thorax:
  • aorta
  • bronchus
  • chest wall
  • clavicle
  • diaphragm
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
  • trachea
Abdomen:
  • adrenal gland
  • kidney
  • stomach
Pelvis:
  • pelvis
  • placenta
  • testicle
  • urinary bladder
  • uterus
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • nail
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal column
  • spinal cord
  • sweat gland
  • vertebrae
genes like me logo Genes that share expression patterns with HRAS: view

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for HRAS Gene

Orthologs for HRAS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HRAS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HRAS 33 34
  • 98.77 (n)
dog
(Canis familiaris)
Mammalia HRAS 33
  • 89.77 (n)
K-RAS 34
  • 75 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HRAS 33 34
  • 88.54 (n)
rat
(Rattus norvegicus)
Mammalia Hras 33
  • 88.36 (n)
mouse
(Mus musculus)
Mammalia Hras 33 16 34
  • 87.65 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 70 (a)
ManyToMany
chicken
(Gallus gallus)
Aves HRAS1 34
  • 98 (a)
OneToOne
HRAS 33
  • 83.42 (n)
lizard
(Anolis carolinensis)
Reptilia HRAS 34
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hras 33
  • 81.31 (n)
Str.6315 33
zebrafish
(Danio rerio)
Actinopterygii hrasa 34
  • 95 (a)
OneToMany
hrasb 34
  • 94 (a)
OneToMany
LOC100151000 33
  • 82.72 (n)
wufa04e08 33
fruit fly
(Drosophila melanogaster)
Insecta Ras85D 35 34
  • 86 (a)
worm
(Caenorhabditis elegans)
Secernentea let-60 34
  • 76 (a)
OneToMany
C08F8.7 35
  • 46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAS1 34
  • 35 (a)
ManyToMany
RAS2 34
  • 34 (a)
ManyToMany
rice
(Oryza sativa)
Liliopsida Os.25522 33
Species where no ortholog for HRAS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HRAS Gene

ENSEMBL:
Gene Tree for HRAS (if available)
TreeFam:
Gene Tree for HRAS (if available)

Paralogs for HRAS Gene

Paralogs for HRAS Gene

genes like me logo Genes that share paralogs with HRAS: view

Variants for HRAS Gene

Sequence variations from dbSNP and Humsavar for HRAS Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs104894226 pathogenic, likely-pathogenic, not-provided, not provided, Chronic lymphocytic leukemia, Hepatocellular carcinoma, Adenocarcinoma of lung, Pancreatic adenocarcinoma, Colorectal Neoplasms, Multiple myeloma, Acute myeloid leukemia, Adenocarcinoma of stomach, Squamous cell carcinoma of lung, Malignant melanoma of skin, Squamous cell carcinoma of the skin, Squamous cell carcinoma of the head and neck, Malignant neoplasm of body of uterus, Transitional cell carcinoma of the bladder, Thymoma, Neoplasm of the breast, Uterine cervical neoplasms, Costello syndrome, Costello syndrome (CSTLO) [MIM:218040] 534,285(-) C/A/G/T 5_prime_UTR_variant, coding_sequence_variant, missense_variant
rs104894227 pathogenic, Costello syndrome, not provided, Costello syndrome (CSTLO) [MIM:218040] 533,553(-) T/C coding_sequence_variant, missense_variant
rs104894228 pathogenic, likely-pathogenic, Costello syndrome, Rasopathy, not provided, Multiple myeloma, Adenocarcinoma of lung, Squamous cell carcinoma of the head and neck, Neoplasm of the breast, Pancreatic adenocarcinoma, Malignant melanoma of skin, Neoplasm of the thyroid gland, Squamous cell carcinoma of lung, Acute myeloid leukemia, Chronic lymphocytic leukemia, Transitional cell carcinoma of the bladder, Malignant neoplasm of body of uterus, Adenocarcinoma of stomach, Neoplasm, Squamous cell carcinoma of the skin, Colorectal Neoplasms, Uterine cervical neoplasms, Hepatocellular carcinoma, Nevus sebaceous, Epidermal nevus syndrome, Epidermal nevus, NEVUS SPILUS, SOMATIC, SPITZ NEVUS, SOMATIC, Schimmelpenning-Feuerstein-Mims syndrome (SFM) [MIM:163200], Costello syndrome (CSTLO) [MIM:218040] 534,286(-) C/A/G/T 5_prime_UTR_variant, coding_sequence_variant, missense_variant
rs104894229 pathogenic, likely-pathogenic, Costello syndrome, Nevus sebaceous, Epidermal nevus, Rasopathy, not provided, Hepatocellular carcinoma, Myelodysplastic syndrome, Colorectal Neoplasms, Squamous cell carcinoma of the skin, Neoplasm of the breast, Acute myeloid leukemia, Adenocarcinoma of lung, Papillary renal cell carcinoma, sporadic, Adenocarcinoma of stomach, Neoplasm of the thyroid gland, Malignant melanoma of skin, Ovarian Serous Cystadenocarcinoma, Nasopharyngeal Neoplasms, Glioblastoma, Multiple myeloma, Carcinoma of esophagus, Uterine Carcinosarcoma, Uterine cervical neoplasms, Squamous cell carcinoma of the head and neck, Malignant neoplasm of body of uterus, Bladder carcinoma, Adenocarcinoma of prostate, Adenoid cystic carcinoma, Pancreatic adenocarcinoma, Transitional cell carcinoma of the bladder, Myopathy, congenital, with excess of muscle spindles, Epidermal nevus with urothelial cancer, somatic, Nevus, woolly hair, not specified, Congenital myopathy with excess of muscle spindles (CMEMS) [MIM:218040], Costello syndrome (CSTLO) [MIM:218040], Costello syndrome (CSTLO) [MIM:218040] 534,289(-) C/A/G/T 5_prime_UTR_variant, coding_sequence_variant, missense_variant
rs104894230 pathogenic, likely-pathogenic, Malignant tumor of urinary bladder, Costello syndrome, Myopathy, congenital, with excess of muscle spindles, Epidermal nevus, not provided, Malignant melanoma, Neoplasm of the thyroid gland, Malignant melanoma of skin, Adenoid cystic carcinoma, Colorectal Neoplasms, Malignant neoplasm of body of uterus, Ovarian Serous Cystadenocarcinoma, Carcinoma of esophagus, Uterine Carcinosarcoma, Transitional cell carcinoma of the bladder, Adenocarcinoma of stomach, Nasopharyngeal Neoplasms, Papillary renal cell carcinoma, sporadic, Squamous cell carcinoma of the head and neck, Hepatocellular carcinoma, Adenocarcinoma of prostate, Squamous cell carcinoma of the skin, Neoplasm of the breast, Acute myeloid leukemia, Glioblastoma, Uterine cervical neoplasms, Myelodysplastic syndrome, Multiple myeloma, Adenocarcinoma of lung, Pancreatic adenocarcinoma, Costello syndrome, severe, Nevus sebaceous, Rasopathy, Bladder carcinoma, Costello syndrome (CSTLO) [MIM:218040], Congenital myopathy with excess of muscle spindles (CMEMS) [MIM:218040], Costello syndrome (CSTLO) [MIM:218040], Costello syndrome (CSTLO) [MIM:218040] 534,288(-) C/A/G/T 5_prime_UTR_variant, coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for HRAS Gene

Variant ID Type Subtype PubMed ID
dgv182e199 CNV deletion 23128226
dgv564n106 OTHER inversion 24896259
esv2759794 CNV loss 17122850
nsv1039558 CNV gain 25217958
nsv1053964 CNV gain 25217958
nsv1077764 OTHER inversion 25765185
nsv1143668 CNV deletion 24896259
nsv1159791 CNV deletion 26073780
nsv467634 CNV loss 19166990
nsv469923 CNV loss 18288195
nsv527327 CNV loss 19592680
nsv552854 CNV loss 21841781
nsv552855 CNV loss 21841781
nsv951270 CNV deletion 24416366

Variation tolerance for HRAS Gene

Residual Variation Intolerance Score: 22.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 4.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HRAS Gene

Human Gene Mutation Database (HGMD)
HRAS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HRAS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HRAS Gene

Disorders for HRAS Gene

MalaCards: The human disease database

(150) MalaCards diseases for HRAS Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards