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HRAS Gene

protein-coding   GIFtS: 76
GCID: GC11M000522

Harvey Rat Sarcoma Viral Oncogene Homolog

(Previous name: v-Ha-ras Harvey rat sarcoma viral oncogene homolog)
(Previous symbol: HRAS1)
  See HRAS-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Harvey Rat Sarcoma Viral Oncogene Homolog1 2     N-RAS2
HRAS11 2 3     RASH12
V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog1 2     C-Has/Bas P21 Protein2
Transforming Protein P212 3     C-Ras-Ki-2 Activated Oncogene2
H-Ras-12 3     GTP- And GDP-Binding Peptide B2
p21ras2 3     GTPase HRas2
C-BAS/HAS2     Ha-Ras1 Proto-Oncoprotein2
C-H-RAS2     P19 H-RasIDX Protein2
C-HA-RAS12     Ras Family Small GTP Binding Protein H-Ras2
CTLO2     Transformation Gene: Oncogene HAMSV2
H-RASIDX2     Ha-Ras3
HAMSV2     c-H-ras3
K-RAS2     

External Ids:    HGNC: 51731   Entrez Gene: 32652   Ensembl: ENSG000001747757   OMIM: 1900205   UniProtKB: P011123   
ORGUL members:         

Export aliases for HRAS gene to outside databases

Previous GC identifers: GC11P001100 GC11P001123 GC11P000664 GC11M000346


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HRAS Gene:
This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian
sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These
proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle
of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi
apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the
prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation,
skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects
in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and
oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified
for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for HRAS Gene:
HRAS (Harvey rat sarcoma viral oncogene homolog) is a protein-coding gene. Diseases associated with HRAS include oral squamous cell carcinoma, and phacomatosis pigmentokeratotica. GO annotations related to this gene include protein C-terminus binding and GTP binding. An important paralog of this gene is REM1.

UniProtKB/Swiss-Prot: RASH_HUMAN, P01112
Function: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity

Gene Wiki entry for HRAS Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NT_187586.1  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HRAS gene promoter:
         NF-1   NF-1/L   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHRAS promoter sequence
   Search Chromatin IP Primers for HRAS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HRAS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

HRAS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HRAS gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M000522:  view genomic region     (about GC identifiers)

Start:
532,242 bp from pter      End:
537,287 bp from pter
Size:
5,046 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RASH_HUMAN, P01112 (See protein sequence)
Recommended Name: GTPase HRas precursor  
Size: 189 amino acids; 21298 Da
Subunit: In its GTP-bound form interacts with PLCE1. Interacts with TBC1D10C. Interacts with RGL3. Interacts with
HSPD1. Found in a complex with at least BRAF, HRAS, MAP2K1, MAPK3 and RGS14. Interacts (active GTP-bound form)
with RGS14 (via RBD 1 domain) (By similarity). Forms a signaling complex with RASGRP1 and DGKZ. Interacts with
RASSF5. Interacts with PDE6D. Interacts with IKZF3. Interacts with GNB2L1. Interacts with PIK3CG; the interaction
is required for membrane recruitment and beta-gamma G protein dimer-dependent activation of the PI3K gamma
complex PIK3CG:PIK3R6 (By similarity). Interacts with RAPGEF2
Mass spectrometry: Mass=6223; Mass_error=2; Method=Electrospray; Range=112-166; Source=PubMed:9020151;
Mass spectrometry: Mass=6253; Mass_error=2; Method=Electrospray; Range=112-166; Note=Includes one nitric oxide
molecule; Source=PubMed:9020151;
Selected PDB 3D structures from and Proteopedia for HRAS (see all 119):
121P (3D)        1AA9 (3D)        1AGP (3D)        1BKD (3D)        1CLU (3D)        1CRP (3D)    
Secondary accessions: B5BUA0 Q14080 Q6FHV9 Q9BR65 Q9UCE2
Alternative splicing: 2 isoforms:  P01112-1   P01112-2   

Explore the universe of human proteins at neXtProt for HRAS: NX_P01112

Explore proteomics data for HRAS at MOPED

Post-translational modifications: 

  • Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid
    exchange between plasma membrane and Golgi1
  • S-nitrosylated; critical for redox regulation. Important for stimulating guanine nucleotide exchange. No
    structural perturbation on nitrosylation1
  • The covalent modification of cysteine by 15-deoxy-Delta12,14-prostaglandin-J2 is autocatalytic and reversible. It
    may occur as an alternative to other cysteine modifications, such as S-nitrosylation and S-palmitoylation1
  • Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs) (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HRAS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001123914.1  NP_005334.1  NP_789765.1  

    ENSEMBL proteins: 
     ENSP00000380722   ENSP00000380723   ENSP00000434023   ENSP00000309845   ENSP00000407586  
     ENSP00000388246  
    Reactome Protein details: P01112

    HRAS Human Recombinant Protein Products:

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    Novus Biologicals HRAS Proteins
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    Sino Biological Recombinant Protein for HRAS
    Sino Biological Cell Lysate for HRAS
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    Cloud-Clone Corp. Proteins for HRAS

     
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    HRAS Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HRAS
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    Search eBioscience for ELISAs for HRAS 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry P01112

    ProtoNet protein and cluster: P01112

    2 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB003577 Ras small GTPase


    UniProtKB/Swiss-Prot: RASH_HUMAN, P01112
    Similarity: Belongs to the small GTPase superfamily. Ras family


    Find genes that share domains with HRAS           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RASH_HUMAN, P01112
    Function: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity
    Enzyme regulation: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by
    a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP)

         Genatlas biochemistry entry for HRAS:
    Harvey rat sarcoma viral (v-Ha-ras1) oncogene homolog

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity ----
    GO:0005515protein binding IPI10369681
    GO:0005525GTP binding IDA14500341
    GO:0008022protein C-terminus binding IPI9219684
    GO:0015093ferrous iron transmembrane transporter activity ----
         
    Find genes that share ontologies with HRAS           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for HRAS:
     Decreased focal adhesion (FA)  

         15 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Hras1):
     behavior/neurological  cardiovascular system  craniofacial  endocrine/exocrine gland  growth/size/body 
     homeostasis/metabolism  integument  mortality/aging  nervous system  no phenotypic analysis 
     normal  renal/urinary system  respiratory system  skeleton  tumorigenesis 

    Find genes that share phenotypes with HRAS           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for HRAS: Hrastm1Mok Hrastm1Esn Hrastm1Grnt

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HRAS
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HRAS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HRAS
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HRAS

    miRNA
    Products:
        
    miRTarBase miRNAs that target HRAS:
    hsa-mir-181d-5p (MIRT006548), hsa-mir-181a-5p (MIRT005880), hsa-let-7a-5p (MIRT004471), hsa-mir-615-3p (MIRT040422), hsa-mir-143-3p (MIRT005644)

    Block miRNA regulation of human, mouse, rat HRAS using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate HRAS:
    hsa-miR-4318 hsa-miR-32* hsa-miR-892a hsa-miR-3667-3p
    SwitchGear 3'UTR luciferase reporter plasmidHRAS 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HRAS
    Predesigned siRNA for gene silencing in human, mouse, rat HRAS

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HRAS

    Clone
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    OriGene clones in human, mouse for HRAS (see all 23)
    OriGene ORF clones in mouse, rat for HRAS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): HRAS (NM_005343)
    Sino Biological Human cDNA Clone for HRAS
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HRAS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HRAS
    Addgene plasmids for HRAS 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for HRAS
    Browse ESI BIO Cell Lines and PureStem Progenitors for HRAS 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HRAS


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RASH_HUMAN, P01112: Cell membrane. Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Golgi
    apparatus membrane; Lipid-anchor. Note=The active GTP-bound form is localized most strongly to membranes than the
    inactive GDP-bound form (By similarity). Shuttles between the plasma membrane and the Golgi apparatus
    RASH_HUMAN, P01112: Isoform 2: Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Colocalizes with GNB2L1
    to the perinuclear region
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    nucleus5
    plasma membrane5
    cytosol4
    cytoskeleton3
    endoplasmic reticulum2
    endosome2
    extracellular2
    mitochondrion2
    peroxisome1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm TAS10842192
    GO:0005794Golgi apparatus IDA14500341

    Find genes that share ontologies with HRAS           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HRAS About   (see all 159)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Development HGF signaling pathway
    Development HGF signaling pathway0.45
    Apoptosis and survival Role of CDK5 in neuronal death and survival0.37
    Development Neurotrophin family signaling0.45
    Apoptosis and survival NGF signaling pathway0.36
    Development EGFR signaling via small GTPases0.44
    Neurotrophin signaling pathway0.36
    Development PDGF signaling via MAPK cascades0.41
    Signaling of Hepatocyte Growth Factor Receptor0.35
    2Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.43
    VEGF signaling pathway0.39
    Immune response BCR pathway0.43
    Fc-epsilon receptor I signaling in mast cells0.34
    Fc epsilon RI signaling pathway0.41
    3B cell receptor signaling pathway (KEGG)
    B cell receptor signaling pathway0.42
    T cell receptor signaling pathway0.38
    BCR signaling pathway0.42
    TCR Signaling Pathway0.36
    4Prolactin Signaling Pathway
    Development Prolactin receptor signaling0.39
    Leptin signaling pathway0.35
    Prolactin Signaling Pathway0.39
    Prolactin signaling pathway0.33
    5ErbB signaling pathway
    ErbB signaling pathway0.52
    EGFR Inhibitor Pathway, Pharmacodynamics0.49
    ErbB signaling pathway0.52


    Find genes that share SuperPaths with HRAS           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HRAS (see all 114)
        Fc-GammaR Pathway
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    Intracellular Calcium Signaling
    CDK5 Pathway

    5 Tocris Bioscience Pathways for HRAS
        Insulin Pathway
    Apoptosis Pathway
    TGF-beta Pathway
    NF-kappaB Pathway
    VEGF Pathway

    Selected GeneGo (Thomson Reuters) Pathways for HRAS (see all 85)
        G-protein signaling Regulation of RAC1 activity
    G-protein signaling H-RAS regulation pathway
    Development A2A receptor signaling
    Development CNTF receptor signaling
    Development EGFR signaling pathway

    Selected BioSystems Pathways for HRAS (see all 43)
        Integrin-mediated cell adhesion
    TGF Beta Signaling Pathway
    Senescence and Autophagy
    EGFR1 Signaling Pathway
    Insulin Signaling

    2 Sino Biological Pathways for HRAS
        VEGF Signaling
    TGF-beta Signaling Pathway

    Selected Reactome Pathways for HRAS (see all 26)
        FCERI mediated MAPK activation
    RAF activation
    RAF phosphorylates MEK
    FRS2-mediated cascade
    EGFR Transactivation by Gastrin

    5 PharmGKB Pathways for HRAS
        Bisphosphonate Pathway, Pharmacodynamics
    EGFR Inhibitor Pathway, Pharmacodynamics
    Sorafenib Pharmacodynamics
    VEGF Signaling Pathway
    Vemurafenib Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for HRAS) (see all 48):
        MAPK signaling pathway
    ErbB signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    Chemokine signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HRAS (see all 16): 
              Lung Cancer in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              Cancer Drug Targets in human mouse rat
              Cellular Senescence in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HRAS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HRAS (P011121, 2, 3 ENSP000003098454) via UniProtKB, MINT, STRING, and/or I2D (see all 640)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAF1P040491, 2, 3, ENSP000002518494EBI-350145,EBI-365996 MINT-6540149 MINT-60984 MINT-7295101 MINT-6802882 MINT-18357 MINT-17120 MINT-6946517 MINT-6540170 MINT-17119 I2D: score=10 STRING: ENSP00000251849
    Rassf5Q5EBH11, 2EBI-350145,EBI-960530 MINT-6948812 MINT-6948939 MINT-6948734 MINT-6948956 MINT-6948715 MINT-6948770 MINT-6949007 MINT-6948973 MINT-6948990 MINT-6948753 MINT-6948790
    RIN1Q136711, 2, 3, ENSP000003104064EBI-350145,EBI-366017 MINT-59464 I2D: score=6 STRING: ENSP00000310406
    CAV1Q031352, 3, ENSP000003391914MINT-14113 MINT-14114 I2D: score=3 STRING: ENSP00000339191
    ABL2P426842, 3, ENSP000003565954MINT-59461 MINT-59462 I2D: score=2 STRING: ENSP00000356595
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 58):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade TAS--
    GO:0000186activation of MAPKK activity TAS--
    GO:0001934positive regulation of protein phosphorylation IDA--
    GO:0006184GTP catabolic process IEA--
    GO:0006897endocytosis IEA--

    Find genes that share ontologies with HRAS           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HRAS (RASH)

    3 HMDB Compounds for HRAS    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    5 DrugBank Compounds for HRAS    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Guanosine-5'-Diphosphate-- 146-91-8target--17139284 17016423 10592235
    Guanosine-5'-Triphosphate-- 86-01-1target--17139284 17016423 10592235
    Hexane-1,6-Diol-- 629-11-8target--17139284 17016423 10592235
    Trifluoroethanol-- --target--17139284 17016423 10592235
    N,N'-DIMETHYL-N-(ACETYL)-N'-(7-NITROBENZ-2-OXA-1,3-DIAZOL-4-YL)ETHYLENEDIAMINE-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for HRAS gene (see all 90)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 72.5 118 8740369 (5), 9345266 (4), 8626511 (4), 1508192 (4) (see all 53)
    dihydroperillic acid 66.3 1 10955786 (1)
    tyrosine 65.7 142 1371879 (5), 7568118 (4), 8407889 (4), 1508192 (4) (see all 81)
    phosphatidylinositol 60.9 33 1716764 (3), 9174058 (1), 16829523 (1), 18355852 (1) (see all 22)
    gdp 60.7 36 8740369 (3), 20483331 (2), 1820685 (1), 1633420 (1) (see all 18)
    azatyrosine 60.7 1 1594588 (1)
    alpha-hydroxyfarnesylphosphonic acid 56.7 2 12941159 (1)
    lovastatin 53.2 25 1673788 (4), 2043425 (4), 7829224 (2), 8425769 (2) (see all 13)
    perillic acid 50.8 1 10955786 (1)
    crcs 46.4 6 15542810 (2), 14639609 (1), 18628094 (1), 18435933 (1)



    Find genes that share compounds with HRAS           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HRAS gene (3 alternative transcripts): 
    NM_001130442.1  NM_005343.2  NM_176795.3  

    Unigene Cluster for HRAS:

    V-Ha-ras Harvey rat sarcoma viral oncogene homolog
    Hs.37003  [show with all ESTs]
    Unigene Representative Sequence: NM_176795
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000478324 ENST00000397594 ENST00000397596 ENST00000493230 ENST00000462734
    ENST00000311189 ENST00000479482 ENST00000468682 ENST00000482021 ENST00000451590(uc001lpv.3 uc010qvx.2)
    ENST00000417302(uc010qvw.2 uc010qvy.2)
    miRNA
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    Block miRNA regulation of human, mouse, rat HRAS using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate HRAS:
    hsa-miR-4318 hsa-miR-32* hsa-miR-892a hsa-miR-3667-3p
    SwitchGear 3'UTR luciferase reporter plasmidHRAS 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for HRAS
    Predesigned siRNA for gene silencing in human, mouse, rat HRAS
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    Additional mRNA sequence: 

    AB451336.1 AB451485.1 AF493916.1 AJ437024.1 BC006499.2 BC095471.1 BT019421.1 CR536579.1 
    CR542271.1 

    8 DOTS entries:

    DT.412426  DT.95375678  DT.97859215  DT.120679118  DT.95375682  DT.101961179  DT.437065  DT.95283676 

    Selected AceView cDNA sequences (see all 131):

    BG060112 BC006499 NM_005343 BG913667 AI536679 BM873522 BM701759 BM708174 
    BM696543 CA335694 BQ021455 BM976656 AF493916 BM894011 BU678078 BQ000825 
    BQ212741 BF725942 BM874789 BM512457 BE208836 BM801632 CK824081 BM995684 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HRAS (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c
    SP1:                                                                                                
    SP2:                                                        -                                       
    SP3:                                                                                                
    SP4:                                                        -                                       
    SP5:                          -     -                       -                                       


    ECgene alternative splicing isoforms for HRAS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HRAS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGTGCCGG
    HRAS Expression
    About this image


    HRAS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neural Tube (Nervous System)
             Spinal Ventral Columns
     
     Bone (Muscoskeletal System)
    HRAS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HRAS Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.37003

    UniProtKB/Swiss-Prot: RASH_HUMAN, P01112
    Tissue specificity: Widely expressed

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HRAS (see all 16): 
              Lung Cancer in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              Cancer Drug Targets in human mouse rat
              Cellular Senescence in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HRAS gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hras15
    Hras1
    Harvey rat sarcoma virus oncogene 15
    Harvey rat sarcoma virus oncogene1
    87.65(n)1
    100(a)1
      7 (86.48 cM)5
    154611  NM_001130443.11  NP_001123915.11 
     1411891055 
    chicken
    (Gallus gallus)
    Aves HRAS1 v-Ha-ras Harvey rat sarcoma viral oncogene homolog 83.42(n)
    97.88(a)
      396229  NM_205292.1  NP_990623.1 
    lizard
    (Anolis carolinensis)
    Reptilia HRAS6
    Harvey rat sarcoma viral oncogene homolog
    97(a)
    1 ↔ 1
    1(74820659-74842582)
    African clawed frog
    (Xenopus laevis)
    Amphibia AY037008.12   -- 83.19(n)    AY037008.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa04e082 wufa04e08 76.68(n)   334824  AI657850.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ras85D3 eggshell pattern formation RAS small
    monomeric more
    86(a)   3 85D21   --
    worm
    (Caenorhabditis elegans)
    Secernentea C08F8.73 RAS-related protein 46(a)   IV(11177461-11178071)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RAS16
    RAS26
    GTPase involved in G-protein signaling in the aden...
    GTP-binding protein that regulates the nitrogen st...
    35(a)
    34(a)
    many ↔ many
    many ↔ many
    XV(515244-516173) YOR101W
    XIV(439602-440570) YNL098C
    rice
    (Oryza sativa)
    Liliopsida Os.255222 Transcribed sequence with weak similarity to protein more 73.7(n)    CA767542.2 


    ENSEMBL Gene Tree for HRAS (if available)
    TreeFam Gene Tree for HRAS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HRAS gene
    REM12  RALA2  RRAS2  RALB2  ERAS2  RRAD2  NRAS2  REM22  
    KRAS2  GEM2  RRAS22  MRAS2  
    Selected SIMAP similar genes for HRAS using alignment to 2 protein entries:     RASH_HUMAN (see all proteins) (see all similar genes):
    K-RAS    N-ras    c-bas/has    KRAS    H-RAS    K-ras
    NRAS    RAP1B    RALA    RAP1A    RIT2    RIT1
    RALB    RAP2A    RRAS2    RRAS    RAP2C    MRAS

    Find genes that share paralogs with HRAS           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HRAS (see all 171)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs289334061,2,,4
    CFollicular thyroid carcinoma samples4 other1533875(-) CCGGCA/CAGGAG 6 K Q mis1 ese30--------
    VAR_0261064
    Faciocutaneoskeletal syndrome (FCSS)4--see VAR_0261062 G A mis40--------
    VAR_0459814
    Faciocutaneoskeletal syndrome (FCSS)4--see VAR_0459812 K R mis40--------
    VAR_0068364
    Faciocutaneoskeletal syndrome (FCSS)4--see VAR_0068362 G V mis40--------
    VAR_0688174
    Schimmelpenning-Feuerstein-Mims syndrome (SFM)4--see VAR_0688172 G R mis40--------
    VAR_0459804
    Congenital myopathy with excess of muscle spindles (CMEMS)4--see VAR_0459802 E K mis40--------
    VAR_0688164
    Faciocutaneoskeletal syndrome (FCSS)4--see VAR_0688162 G D mis40--------
    VAR_0459824
    Faciocutaneoskeletal syndrome (FCSS)4--see VAR_0459822 A T mis40--------
    VAR_0068374
    Faciocutaneoskeletal syndrome (FCSS)4--see VAR_0068372 G S mis40--------
    VAR_0459774
    Congenital myopathy with excess of muscle spindles (CMEMS)4--see VAR_0459772 Q K mis40--------

    HapMap Linkage Disequilibrium report for HRAS (532242 - 537287 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HRAS (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv182e199CNV Deletion23128226
    nsv896548CNV Loss21882294
    nsv896545CNV Loss21882294
    dgv931n71CNV Loss21882294
    nsv469923CNV Loss18288195
    dgv933n71CNV Loss21882294
    dgv918n71CNV Loss21882294
    dgv916n71CNV Loss21882294
    dgv922n71CNV Loss21882294
    dgv934n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): HRAS
    Selected Site Specific Mutation Identification with PCR Assays for HRAS (see all 15):
    Cosmic IdAA Change
    482p.G12R
    498p.Q61L
    484p.G12D
    487p.G13S
    502p.Q61H
    Selected Site Specific Cancer Mutation PCR Panels containing HRAS (see all 26):
    Breast Cancer
    Receptor Tyrosine Kinase (RTK) (Panel II)
    Cancer Comprehensive Panel 384HT
    Lung Cancer
    1 Copy Number PCR Panel containing HRAS:
    Oncogenes & Tumor Suppressor Genes 384HC
    SeqTarget long-range PCR primers for resequencing HRAS
    DNA2.0 Custom Variant and Variant Library Synthesis for HRAS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 190020   
    OMIM disorders: 109800  218040  188470  162900  163200  
    UniProtKB/Swiss-Prot: RASH_HUMAN, P01112
  • Faciocutaneoskeletal syndrome (FCSS) [MIM:218040]: A rare condition characterized by prenatally increased
    growth, postnatal growth deficiency, mental retardation, distinctive facial appearance, cardiovascular
    abnormalities (typically pulmonic stenosis, hypertrophic cardiomyopathy and/or atrial tachycardia), tumor
    predisposition, skin and musculoskeletal abnormalities. Note=The disease is caused by mutations affecting the
    gene represented in this entry
  • Congenital myopathy with excess of muscle spindles (CMEMS) [MIM:218040]: Variant of Costello syndrome.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Hurthle cell thyroid carcinoma (HCTC) [MIM:607464]: A rare type of thyroid cancer accounting for only
    about 3-10% of all differentiated thyroid cancers. These neoplasms are considered a variant of follicular
    carcinoma of the thyroid and are referred to as follicular carcinoma, oxyphilic type. Note=Disease susceptibility
    is associated with variations affecting the gene represented in this entry
  • Note=Mutations which change positions 12, 13 or 61 activate the potential of HRAS to transform cultured
    cells and are implicated in a variety of human tumors
  • Bladder cancer (BLC) [MIM:109800]: A malignancy originating in tissues of the urinary bladder. It often
    presents with multiple tumors appearing at different times and at different sites in the bladder. Most bladder
    cancers are transitional cell carcinomas that begin in cells that normally make up the inner lining of the
    bladder. Other types of bladder cancer include squamous cell carcinoma (cancer that begins in thin, flat cells)
    and adenocarcinoma (cancer that begins in cells that make and release mucus and other fluids). Bladder cancer is
    a complex disorder with both genetic and environmental influences. Note=Disease susceptibility is associated with
    variations affecting the gene represented in this entry
  • Note=Defects in HRAS are the cause of oral squamous cell carcinoma (OSCC)
  • Schimmelpenning-Feuerstein-Mims syndrome (SFM) [MIM:163200]: A disease characterized by sebaceous nevi,
    often on the face, associated with variable ipsilateral abnormalities of the central nervous system, ocular
    anomalies, and skeletal defects. Many oral manifestations have been reported, not only including hypoplastic and
    malformed teeth, and mucosal papillomatosis, but also ankyloglossia, hemihyperplastic tongue, intraoral nevus,
    giant cell granuloma, ameloblastoma, bone cysts, follicular cysts, oligodontia, and odontodysplasia. Sebaceous
    nevi follow the lines of Blaschko and these can continue as linear intraoral lesions, as in mucosal
    papillomatosis. Note=The disease is caused by mutations affecting the gene represented in this entry

  • Selected diseases for HRAS (see all 27):    
    About MalaCards
    oral squamous cell carcinoma    phacomatosis pigmentokeratotica    schimmelpenning-feuerstein-mims syndrome, somatic mosaic    bladder cancer, somatic
    costello syndrome    congenital myopathy with excess of muscle spindles    phakomatosis pigmentokeratotica    spitz nevus
    nevus sebaceous, somatic    sfm syndrome, somatic mosaic    brown-vialetto-van laere syndrome 2    thyroid cancer
    gastrointestinal system disease    brown-vialetto-van laere syndrome    thyroid carcinoma, follicular, somatic    core binding factor acute myeloid leukemia
    leopard syndrome    male germ cell tumor    sarcoma    cardiofaciocutaneous syndrome

    Selected diseases from the University of Copenhagen DISEASES database for HRAS (see all 26):
    Colorectal cancer     Carcinoma     Lung cancer     Pancreatic cancer
    Adenoma     Melanoma     Leukemia     Autosomal dominant disease
    Breast cancer     Endometrial cancer     Papilloma     Urinary bladder cancer
    Lymphoma     Pancreatitis     Gallbladder cancer     Thyroid cancer
    Ovarian cancer     Exanthem     Intellectual disability     Retinoblastoma

    Find genes that share disorders with HRAS           About GenesLikeMe

    Selected Novoseek inferred disease relationships for HRAS gene (see all 92)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cfc syndrome 89.1 19 18651097 (2), 17366577 (2), 20052757 (1), 17483702 (1) (see all 10)
    noonan syndrome 85.1 39 18958496 (4), 17056636 (3), 16474405 (3), 19020799 (2) (see all 22)
    microsatellite instability 67 11 19186181 (1), 19513025 (1), 19908233 (1), 15294875 (1) (see all 10)
    colorectal cancer 61.2 72 15294875 (5), 11192825 (3), 12722796 (3), 14688025 (3) (see all 41)
    tumors 60.2 276 15753399 (4), 18268007 (4), 9563885 (3), 12788883 (3) (see all 99)
    adenocarcinoma lung 55.3 6 20007840 (2), 19162366 (1), 19826477 (1), 17024970 (1) (see all 5)
    short stature 51.6 8 16921267 (1), 17211612 (1), 18958496 (1), 17601930 (1) (see all 6)
    colon cancer 51.4 24 19843849 (4), 12009696 (3), 12652573 (2), 18790789 (1) (see all 14)
    colorectal tumors 51.3 7 16707468 (1), 19956069 (1), 8625092 (1), 10639144 (1) (see all 7)
    cancer 50.9 83 20477713 (5), 20005451 (3), 18418066 (3), 12788883 (2) (see all 44)

    GeneTests: HRAS
    GeneReviews: HRAS
    Genetic Association Database (GAD): HRAS
    Human Genome Epidemiology (HuGE) Navigator: HRAS (39 documents)
    Tumor Gene Database (TGDB): HRAS

    Export disorders for HRAS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HRAS gene, integrated from 10 sources (see all 1384):
    (articles sorted by number of sources associating them with HRAS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Absence of oncogenic mutations of RAS family genes in soft tissue sarcomas of 100 Japanese patients. (PubMed id 20150643)1, 4, 9 Jin Y....Toguchida J. (Anticancer Res. 2010)
    2. Cognitive profile of disorders associated with dysregulation of the RAS/MAPK signaling cascade. (PubMed id 19133693)1, 4, 9 Cesarini L....Zampino G. (Am. J. Med. Genet. A 2009)
    3. Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles for BRAF, PIK3CA, and AKT1. (PubMed id 19487299)1, 4, 9 Ricarte-Filho J.C....Fagin J.A. (Cancer Res. 2009)
    4. Association between H-RAS T81C genetic polymorphism and gastrointestinal cancer risk: a population based case-control study in China. (PubMed id 18783589)1, 4, 9 Zhang Y....Chen K. (BMC Cancer 2008)
    5. Influence of single nucleotide polymorphisms in H-Ras and cyclin D1 genes on oral cancer susceptibility. (PubMed id 16488657)1, 4, 9 Sathyan K.M....Kannan S. (Oral Oncol. 2006)
    6. Alternative splicing of the human proto-oncogene c-H-ras renders a new Ras family protein that trafficks to cytoplasm and nucleus. (PubMed id 14500341)1, 2, 9 Guil S.... Bach-Elias M. (Cancer Res. 2003)
    7. Postzygotic HRAS and KRAS mutations cause nevus sebaceous and Schimmelpenning syndrome. (PubMed id 22683711)1, 2 Groesser L.... Hafner C. (Nat. Genet. 2012)
    8. Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns. (PubMed id 20526288)1, 4 Rivera M....Ghossein R.A. (Mod. Pathol. 2010)
    9. [Study on association between an H-RAS gene polymorphism and gastric cancer development]. (PubMed id 20729618)1, 4 Kwack K.B....Cho S.W. (Korean J Gastroenterol 2010)
    10. Molecular, morphologic, and outcome analysis of thyroid carcinomas according to degree of extrathyroid extension. (PubMed id 20860430)1, 4 Rivera M....Ghossein R. (Thyroid 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3265 HGNC: 5173 AceView: HRAS Ensembl:ENSG00000174775 euGenes: HUgn3265
    ECgene: HRAS Kegg: 3265 H-InvDB: HRAS

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HRAS Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HRAS Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=HRAS[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HRAS gene:
    Search GeneIP for patents involving HRAS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     SwitchGear 3'UTR luciferase reporter plasmids for HRAS
     SwitchGear Promoter luciferase reporter plasmids for HRAS
     ThermoFisher Antibody for HRAS
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HRAS
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HRAS
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HRAS
     LSBio Antibodies in human, mouse, rat for HRAS
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for HRAS
      Search eBioscience for proteins for HRAS
      Search eBioscience for elisas for HRAS
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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