Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HPX Gene

protein-coding GIFtS: 60
GCID: GC11M006452

hemopexin

Explore 32 diseases affiliated with
HPX via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Hemopexin¹
HX²
Beta-1B-Glycoprotein¹
Beta-1B-Glycoprotein¹

External Ids:	HGNC: 5171¹	Entrez Gene: 3263²	Ensembl: ENSG00000110169⁷	OMIM: 142290⁵	UniProtKB: P02790³

Export aliases for HPX gene to outside databases

Previous GC identifers: GC11M007195 GC11M006912 GC11M006411 GC11M006416 GC11M006408 GC11M006112

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HPX:

This gene encodes a plasma glycoprotein that binds heme with high affinity. The encoded protein is an acute phase

protein that transports heme from the plasma to the liver and may be involved in protecting cells from oxidative

stress. (provided by RefSeq, Apr 2009)

UniProtKB/Swiss-Prot: HEMO_HUMAN, P02790

Function: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin

returns to the circulation

Gene Wiki entry for HPX (Hemopexin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HPX gene promoter:
p300 ATF-2 C/EBPalpha GATA-2 CHOP-10 E2F E2F-1 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HPX promoter sequence

Search SABiosciences Chromatin IP Primers for HPX

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HPX

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5-p15.4 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.5-p15.4

HPX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HPX gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M006452: view genomic region (about GC identifiers)

Start:	6,452,268 bp from pter	End:	6,463,847 bp from pter
Size:	11,580 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HEMO_HUMAN, P02790 (See protein sequence)

Recommended Name: Hemopexin precursor

Size: 462 amino acids; 51676 Da

Subunit: Interacts with HEV ORF3 protein. Interacts with FLVCR1

Subcellular location: Secreted

Miscellaneous: The isolated N-terminal domain binds one heme. The full-length protein also binds one heme, but at a

different site. The physiological significance of this is not clear (By similarity)

Sequence caution: Sequence=CAA26382.1; Type=Erroneous initiation;

Secondary accessions: B2R957

Explore the universe of human proteins at neXtProt for HPX: NX_P02790

Post-translational modifications:

N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. O-glycosylation in the 30-40 region is

minor compared to glycosylation at Thr-24 and Thr-29¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P02790

HPX Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000604.1

ENSEMBL proteins:

ENSP00000265983

Reactome Protein details: P02790
Human Recombinant Protein Products for HPX:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for HPX (Hemopexin)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: HPX OriGene Protein Over-expression Lysate: HPX OriGene Custom Protein Services for HPX
	GenScript Custom Purified and Recombinant Proteins Services for HPX
	Novus Biologicals HPX Protein Novus Biologicals HPX Lysates
	Sino Biological Recombinant Protein for HPX
	ProSpec Recombinant Protein for HPX
	Uscn Proteins for HPX

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	14718574
GO:0005615	extracellular space	IDA	19433579

HPX for ontologies About GeneDecksing

HPX Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for HPX (Hemopexin)
	OriGene Antibodies: HPX OriGene Custom Antibody Services for HPX
	GenScript Custom Superior Antibodies Services for HPX
	Novus Biologicals HPX Antibodies
	Abcam antibodies for HPX
	Uscn Antibodies for HPX
	ThermoFisher Antibodies for HPX

Assay Products for HPX:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for HPX
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for HPX

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HPX for domains About GeneDecksing

4 InterPro domains/families:

IPR000585 Hemopexin/matrixin

IPR018486 Hemopexin/matrixin_CS

IPR016358 Hemopexin_chordata

IPR018487 Hemopexin/matrixin_repeat

Graphical View of Domain Structure for InterPro Entry P02790

ProtoNet protein and cluster: P02790

UniProtKB/Swiss-Prot: HEMO_HUMAN, P02790

Similarity: Belongs to the hemopexin family

Similarity: Contains 5 hemopexin-like domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: HEMO_HUMAN, P02790

Function: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin

returns to the circulation

Genatlas biochemistry entry for HPX:

hemopexin,beta 1 glycoprotein of blood serum

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005488	binding	--	--
GO:0005515	protein binding	IPI	--
GO:0015232	heme transporter activity	TAS	3855550
GO:0046872	metal ion binding	IEA	--

HPX for ontologies About GeneDecksing

Phenotypes:
6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Hpx):

hematopoietic system	homeostasis/metabolism	immune system	liver/biliary system	mortality/aging
renal/urinary system

HPX for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HPX

miRNA Products:		OriGene 3'-UTR Clone: HPX Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HPX
		1 QIAGEN miScript miRNA Assays for microRNA that regulate HPX:
		hsa-miR-3185
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HPX (see all 4) OriGene shRNA RFP: HPX OriGene siRNA: HPX
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HPX
		Sirion Biotech Custom design and validation of potent shRNA sequences against HPX

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for HPX
			Sirion Biotech Customized adenovirus for overexpression of HPX Sirion Biotech Customized adenovirus for potent knockdown of HPX

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HPX (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HPX OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HPX (NM_000613)
		Sino Biological Human cDNA Clone for HPX
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HPX
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HPX

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HPX
		Search LifeMap BioReagents cell lines for HPX
		Sirion Biotech Customized stable knockdown cell line services for HPX Sirion Biotech Customized inducible knockdown cell line services for HPX Sirion Biotech Customized stable overexpressing cell line services for HPX Sirion Biotech Customized inducible overexpressing cell line services for HPX

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HPX

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cleavage of Alpha-1-Microglobulin

Scavenging of Heme from Plasma

0.79

Binding and Uptake of Ligands by Scavenger Receptors

0.79

Endocytosis of LRP1:Hemopexin:heme

Endocytosis of LRP1:Hemopexin:heme

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Reactome Pathways for HPX

	Endocytosis of LRP1:Hemopexin:heme
	Scavenging of Heme from Plasma
	Binding and Uptake of Ligands by Scavenger Receptors

HPX for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for HPX

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

5/6 Interacting proteins for HPX (P02790³ ENSP00000265983⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ALB	P02768³, ENSP00000295897⁴	I2D: score=1 STRING: ENSP00000295897
KCNMA1	Q12791³	I2D: score=1
LGALS3	P17931³	I2D: score=1
LGALS8	O00214³	I2D: score=1
GLUD1	ENSP00000277865⁴	STRING: ENSP00000277865

About this table

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002639	positive regulation of immunoglobulin production	IEA	--
GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin	IEA	--
GO:0006879	cellular iron ion homeostasis	TAS	3855550
GO:0015886	heme transport	TAS	3855550
GO:0019048	virus-host interaction	IEA	--

HPX for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

HPX for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HPX

2 HMDB Compounds for HPX About this table

Compound	Synonyms	CAS #	PubMed Ids
Heme	(protoporphyrinato)iron (see all 19)	14875-96-8	--
Iron	Armco iron (see all 19)	7439-89-6	--

1 DrugBank Compound for HPX About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Heme	--	--	target	--	10592235

10/31 Novoseek chemical compound relationships for HPX gene (see all 31) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
haem	58.9	8	17712531 (2), 11563695 (1), 15697212 (1), 9588949 (1) (see all 5)
apotransferrin	57.8	1	15507294 (1)
iron	49.8	31	8262649 (5), 2380200 (3), 7768617 (2), 12468596 (1) (see all 16)
hepa	44.7	1	1964416 (1)
porphyrin	42.4	3	10737728 (1), 7768617 (1), 7671136 (1)
cyanide	34.1	1	8087243 (1)
fibrinogen	31	18	9061799 (4), 17786358 (1), 10199063 (1), 14586134 (1) (see all 8)
hydroxamate	29.9	2	12475252 (1)
histidine	25.8	5	7681064 (2), 8692902 (1), 1988069 (1), 8078898 (1)
fe3+	22.9	2	8855948 (1)

Search CenterWatch for drugs/clinical trials and news about HPX / HEMO

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HPX gene:

NM_000613.2

Unigene Cluster for HPX:

Hemopexin

Hs.426485 [show with all ESTs]

Unigene Representative Sequence: NM_000613

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000265983(uc001mdg.2 uc009yfc.2) ENST00000527556 ENST00000529037

ENST00000533561 ENST00000534429 ENST00000529775 ENST00000525057 ENST00000533369

ENST00000533856 ENST00000528348(uc010rai.1) ENST00000534800 ENST00000527105

miRNA Products:		OriGene 3'-UTR Clone: HPX Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HPX
		1 QIAGEN miScript miRNA Assays for microRNA that regulate HPX:
		hsa-miR-3185
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HPX (see all 4) OriGene shRNA RFP: HPX OriGene siRNA: HPX
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HPX
		Sirion Biotech Custom design and validation of potent shRNA sequences against HPX

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HPX (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HPX OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HPX (NM_000613)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HPX
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HPX

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HPX Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HPX
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HPX
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HPX

Additional cDNA sequence:

AK303758.1 AK313648.1 BC005395.1 J03048.1 X02537.1

12 DOTS entries:

DT.452528 DT.92438663 DT.92438665 DT.120715441 DT.100816455 DT.120715437 DT.100816468 DT.100816466

DT.100816469 DT.120715433 DT.95073745 DT.120715439

24/287 AceView cDNA sequences (see all 287):

AV650721 AV653354 NM_000613 AV652771 AV645403 AL534855 BX440692 T71654

CR597029 CR595529 T68103 AV660098 AV651372 AW965111 AV651359 AV646380

CR617142 BC005395 AV658818 CB158449 CR601115 R17061 X02537 AV652762

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for HPX (see all 9) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	·	3d	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	·	9c	·	9d	^	10	^	11a	·	11b	^	12	^	13a	·	13b
SP1:													-												-		-								-
SP2:					-		-		-		-		-												-		-
SP3:													-												-		-
SP4:							-		-		-		-
SP5:													-

ECgene alternative splicing isoforms for HPX

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HPX expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTCTGGCCT

About this image

HPX expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Lobule

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Primitive gut tube-like cells (A scalable, suspensi...)

See HPX Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HPX

SOURCE GeneReport for Unigene cluster: Hs.426485

UniProtKB/Swiss-Prot: HEMO_HUMAN, P02790

Tissue specificity: Expressed by the liver and secreted in plasma

SABiosciences Expression via Pathway-Focused PCR Array including HPX:

Molecular Toxicology PathwayFinder 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HPX Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HPX
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HPX
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HPX

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HPX

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for HPX gene from 5/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Hpx^{1 , 5}	hemopexin^{1, 5}	81.87(n)¹ 75.66(a)¹		7 (55.91 cM)⁵ 15458¹ NM_017371.2¹ NP_059067.2¹ 105591613⁵
chicken (Gallus gallus)	Aves	HPX¹	hemopexin	58.01(n) 48.34(a)		419076 XM_417267.3 XP_417267.3
lizard (Anolis carolinensis)	Reptilia	HPX⁶	--	44(a)	1 ↔ 1	AAWZ02040500(707-4081)
African clawed frog (Xenopus laevis)	Amphibia	CF521889.1²	--	72.73(n)		CF521889.1
zebrafish (Danio rerio)	Actinopterygii	hpx¹	hemopexin	50.04(n) 38.07(a)		327588 NM_001111147.1 NP_001104617.1

ENSEMBL Gene Tree for HPX (if available)
TreeFam Gene Tree for HPX (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183427921^1,2		--	6451841(+)	`AGCCAC/TGAGTG`	1	--	ds500¹		0	--	--	--	--
rs187749251^1,2		--	6451847(+)	`GAGTGG/TTGTTA`	1	--	ds500¹		0	--	--	--	--
rs117568055^1,2	F	--	6451952(+)	`CCAGGC/TCCTGT`	1	--	ds500¹		1		EA	120
rs190634222^1,2		--	6452062(+)	`TCTTCC/TGACTC`	1	--	ds500¹		0	--	--	--	--
rs183298361^1,2		--	6452084(+)	`CCCCCA/C/G/T ACTAT`	1	--	ds500¹		0	--	--	--	--
rs74053380^1,2	C	--	6452169(+)	`TAGTGC/TTCCCC`	1	--	ds500¹		1		WA	2
rs188345120^1,2		--	6452263(+)	`TTCACA/GACCAA`	1	--	ds500¹		0	--	--	--	--
rs192531166^1,2		--	6452348(+)	`ATGTCA/GGAAGG`	1	--	ut3¹		0	--	--	--	--
rs145264256^1,2		--	6452370(+)	`GAAGCA/GAAGAA`	1	--	ut3¹		0	--	--	--	--
rs77660779^1,2	C	--	6452438(+)	`AAGGCC/ACCTCA`	1	--	ut3¹		2		WA EU	1429

HapMap Linkage Disequilibrium report for HPX (6452268 - 6463847 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HPX: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HPX

DNA2.0 Custom Variant and Variant Library Synthesis for HPX

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HPX for disorders           About GeneDecksing

OMIM gene information: 142290    OMIM disorders: --

20/32 diseases for HPX (see all 32):    About MalaCards

porphyria cutanea tarda retinol binding protein blackwater fever iron overload

haemophilus influenzae porphyria hemolytic anemia hepatitis e

rheumatoid arthritis osteolysis diabetes mellitus laryngitis

anemia arthritis influenza laryngeal cancer

liver disease atherosclerosis hepatocellular carcinoma alzheimer's disease

10/15 Novoseek disease relationships for HPX gene (see all 15) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hemolysis intravascular	76.8	7	18556779 (2), 11580905 (2), 20386613 (1), 12805012 (1) (see all 5)
hemolysis	50.7	11	11580905 (2), 20074563 (1), 2093885 (1), 19039664 (1) (see all 8)
proteinuria	22.5	3	2253403 (1), 18753258 (1)
inflammation	22.5	6	15038107 (1), 10504726 (1), 14586134 (1), 17185359 (1) (see all 6)
anemia hemolytic	18.4	1	11580905 (1)
atherosclerosis	12.6	2	15236792 (1), 2132529 (1)
preeclampsia	1.55	4	17469012 (2), 19414647 (2)
rheumatoid arthritis	1.11	1	15038107 (1)
bleeding	0	1	8201257 (1)
necrosis	0	4	11699640 (3), 15113099 (1)

Human Genome Epidemiology (HuGE) Navigator: HPX (3 documents)

Export disorders for HPX gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for HPX gene, integrated from 9 sources (see all 250):
(articles sorted by number of sources associating them with HPX)

Utopia: connect your pdf to the dynamic
world of online information

Structure of the human hemopexin gene and evidence for intron-mediated evolution. (PubMed id 2842511)^{1, 2, 3} Altruda F....Silengo L. (1988)
The primary structure of human hemopexin deduced from cDNA sequence: evidence for internal, repeating homology. (PubMed id 2989777)^{1, 2, 3} Altruda F.... Silengo L. (1985)
Kinetics and specificity of feline leukemia virus sub group C receptor (FLVCR) export function and its dependence on hemopexin. (PubMed id 20610401)^{1, 2} Yang Z....Abkowitz J.L. (2010)
Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)^{1, 2} Ramachandran P....Loo J.A. (2006)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (2005)
A proteomic analysis of human bile. (PubMed id 15084671)^{1, 2} Kristiansen T.Z.... Pandey A. (2004)
Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. (PubMed id 14760718)^{1, 2} Bunkenborg J.... Wisniewski J.R. (2004)
The hemopexin gene maps to the same location as the beta-globin gene cluster on human chromosome 11. (PubMed id 3220477)^{1, 2} Law M.L.... Kao F.T. (1988)
Complete amino acid sequence of human hemopexin, the heme-binding protein of serum. (PubMed id 3855550)^{1, 2} Takahashi N.... Putnam F.W. (1985)
Structure of human hemopexin: O-glycosyl and N-glycosyl sites and unusual clustering of tryptophan residues. (PubMed id 6371807)^{1, 2} Takahashi N.... Putnam F.W. (1984)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3263	HGNC: 5171	AceView: HPX	Ensembl:ENSG00000110169	euGenes: HUgn3263
ECgene: HPX	H-InvDB: HPX

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HPX	Pharmacogenomics, SNPs, Pathways

Intellectual Property for HPX gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for HPX gene:
Search GeneIP for patents involving HPX

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for HPX (Hemopexin)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for HPX (Hemopexin)

	OriGene Antibodies for HPX		OriGene shRNA RFP for HPX
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HPX		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HPX
	OriGene Protein Over-expression Lysate for HPX		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for HPX		OriGene 3'-UTR Clone for HPX
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HPX		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HPX
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for HPX		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for HPX		OriGene Custom Protein Services for HPX
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HPX
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HPX
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HPX
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HPX
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HPX
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HPX

	GenScript Custom Purified and Recombinant Proteins Services for HPX		GenScript cDNA clones with any tag delivered in your preferred vector for HPX
	GenScript Custom Assay Services for HPX		GenScript Custom Superior Antibodies Services for HPX
	GenScript Custom overexpressing Cell Line Services for HPX		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in HPX promoter
	Search Chromatin IP Primers for HPX
	RT² qPCR Primer Assay in human, mouse, rat HPX
	GNC Network for HPX
	SABiosciences PCR Arrays including human, mouse, rat HPX

Search Tocris compounds for HPX

	Proteins and Antibodies for HPX
	cDNA Clones for HPX
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	HPX antibodies
	HPX proteins
	HPX lysates

	Antibodies for HPX
	See all of Abcam's Antibodies, Kits and Proteins for HPX
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for HPX

HPX Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for HPX

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HPX

	Browse SwitchGear 3'UTR luciferase reporter plasmids for HPX
	SwitchGear Promoter luciferase reporter plasmids for HPX

ThermoFisher Antibodies for HPX

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HPX

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HPX

Sirion Biotech Customized:

	stable knockdown cell line services for HPX
	inducible knockdown cell line services for HPX
	design and validation of potent shRNA sequences against HPX
	adenovirus for potent knockdown of HPX
	adenovirus for overexpression of HPX
	stable overexpressing cell line services for HPX
	inducible overexpressing cell line services for HPX

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes HPX gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

HPX Gene

hemopexin

Aliases
for HPX gene

Summaries
for HPX gene

Genomic Views
for HPX gene

Proteins
for HPX gene

Protein Domains /
Families
for HPX gene

Function
for HPX gene

Pathways & Interactions
for HPX gene

Drugs & Compounds
for HPX gene

Transcripts
for HPX gene

Expression
for HPX gene

Orthologs
for HPX gene

Paralogs
for HPX gene

Genomic Variants
for HPX gene

Disorders / Diseases
for HPX gene

Publications
for HPX gene

External Searches for HPX gene

Genome Databases showing HPX gene

Other Databases showing HPX gene

Specialized Databases showing HPX gene

Intellectual Property
for HPX gene

Products
for HPX gene

View Random Gene

Advanced Search

Export list of displayed genes

HPX Gene

hemopexin

Aliasesfor HPX gene

Summariesfor HPX gene

Genomic Viewsfor HPX gene

Proteinsfor HPX gene

Protein Domains /Familiesfor HPX gene

Functionfor HPX gene

Pathways & Interactionsfor HPX gene

Drugs & Compoundsfor HPX gene

Transcriptsfor HPX gene

Expression for HPX gene

Orthologsfor HPX gene

Paralogsfor HPX gene

Genomic Variantsfor HPX gene

Disorders / Diseasesfor HPX gene

Publicationsfor HPX gene

External Searches for HPX gene

Genome Databases showing HPX gene

Other Databases showing HPX gene

Specialized Databases showing HPX gene

Intellectual Propertyfor HPX gene

Productsfor HPX gene

View Random Gene

Aliases
for HPX gene

Summaries
for HPX gene

Genomic Views
for HPX gene

Proteins
for HPX gene

Protein Domains /
Families
for HPX gene

Function
for HPX gene

Pathways & Interactions
for HPX gene

Drugs & Compounds
for HPX gene

Transcripts
for HPX gene

Expression
for HPX gene

Orthologs
for HPX gene

Paralogs
for HPX gene

Genomic Variants
for HPX gene

Disorders / Diseases
for HPX gene

Publications
for HPX gene

Intellectual Property
for HPX gene

Products
for HPX gene