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HPX Gene

protein-coding   GIFtS: 61
GCID: GC11M006452

Hemopexin

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
hemopexin1 2
HX2
beta-1B-glycoprotein2
Beta-1B-glycoprotein3

External Ids:    HGNC: 51711   Entrez Gene: 32632   Ensembl: ENSG000001101697   OMIM: 1422905   UniProtKB: P027903   

Export aliases for HPX gene to outside databases

Previous GC identifers: GC11M007195 GC11M006912 GC11M006411 GC11M006416 GC11M006408 GC11M006112


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HPX Gene:
This gene encodes a plasma glycoprotein that binds heme with high affinity. The encoded protein is an acute phase
protein that transports heme from the plasma to the liver and may be involved in protecting cells from oxidative
stress. (provided by RefSeq, Apr 2009)

GeneCards Summary for HPX Gene:
HPX (hemopexin) is a protein-coding gene. Diseases associated with HPX include blackwater fever, and hepatitis e. GO annotations related to this gene include heme transporter activity.

UniProtKB/Swiss-Prot: HEMO_HUMAN, P02790
Function: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free
hemopexin returns to the circulation

Gene Wiki entry for HPX (Hemopexin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HPX gene promoter:
         p300   ATF-2   C/EBPalpha   GATA-2   CHOP-10   E2F   E2F-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHPX promoter sequence
   Search Chromatin IP Primers for HPX

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HPX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5-p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.5-p15.4

HPX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HPX gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M006452:  view genomic region     (about GC identifiers)

Start:
6,452,268 bp from pter      End:
6,463,847 bp from pter
Size:
11,580 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HEMO_HUMAN, P02790 (See protein sequence)
Recommended Name: Hemopexin precursor  
Size: 462 amino acids; 51676 Da
Subunit: Interacts with HEV ORF3 protein. Interacts with FLVCR1
Miscellaneous: The isolated N-terminal domain binds one heme. The full-length protein also binds one heme, but at
a different site. The physiological significance of this is not clear (By similarity)
Sequence caution: Sequence=CAA26382.1; Type=Erroneous initiation;
Secondary accessions: B2R957

Explore the universe of human proteins at neXtProt for HPX: NX_P02790

Explore proteomics data for HPX at MOPED

Post-translational modifications: 

  • N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. O-glycosylation in the 30-40 region
    is minor compared to glycosylation at Thr-24 and Thr-291
  • Glycosylation2 at Thr24, Thr29, Asn64, Asn187, Asn240, Asn246, Asn453
  • Modification sites at PhosphoSitePlus

  • See HPX Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000604.1  
    ENSEMBL proteins: 
     ENSP00000265983  
    Reactome Protein details: P02790

    HPX Human Recombinant Protein Products:

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    R&D Systems Recombinant & Natural Proteins for HPX (Hemopexin)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for HPX
    OriGene Protein Over-expression Lysate for HPX
    OriGene MassSpec for HPX
    OriGene Custom Protein Services for HPX
    GenScript Custom Purified and Recombinant Proteins Services for HPX
    Novus Biologicals HPX Protein
    Novus Biologicals HPX Lysates
    Sino Biological Recombinant Protein for HPX
    Sino Biological Cell Lysate for HPX
    ProSpec Recombinant Protein for HPX
    Cloud-Clone Corp. Proteins for HPX

    HPX Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for HPX (Hemopexin)
    OriGene Antibodies for HPX
    OriGene Custom Antibody Services for HPX
    Novus Biologicals HPX Antibodies
    Abcam antibodies for HPX
    Cloud-Clone Corp. Antibodies for HPX
    ThermoFisher Antibodies for HPX
    LSBio Antibodies in human, mouse, rat for HPX

    HPX Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HPX
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HPX
    Cloud-Clone Corp. CLIAs for HPX


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR000585 Hemopexin-like_dom
     IPR018486 Hemopexin_CS
     IPR016358 Hemopexin_chordata
     IPR018487 Hemopexin-like_repeat

    Graphical View of Domain Structure for InterPro Entry P02790

    ProtoNet protein and cluster: P02790

    UniProtKB/Swiss-Prot: HEMO_HUMAN, P02790
    Similarity: Belongs to the hemopexin family
    Similarity: Contains 8 hemopexin repeats


    HPX for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HEMO_HUMAN, P02790
    Function: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free
    hemopexin returns to the circulation

         Genatlas biochemistry entry for HPX:
    hemopexin,beta 1 glycoprotein of blood serum

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--
    GO:0015232heme transporter activity TAS3855550
    GO:0046872metal ion binding ----
         
    HPX for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hpx):
     hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system  mortality/aging 
     renal/urinary system 

    HPX for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HPX
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HPX

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HPX
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HPX

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat HPX using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate HPX:
    hsa-miR-3185
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HPX
    Predesigned siRNA for gene silencing in human, mouse, rat HPX

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HPX

    Clone
    Products:
         
    OriGene clones in human, mouse for HPX (see all 7)
    OriGene ORF clones in mouse, rat for HPX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HPX (NM_000613)
    Sino Biological Human cDNA Clone for HPX
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HPX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HPX

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HPX
    Browse ESI BIO Cell Lines and PureStem Progenitors for HPX 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HPX


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HEMO_HUMAN, P02790: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane2
    cytosol1
    endoplasmic reticulum1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA19433579
    GO:0031012extracellular matrix IEA--
    GO:0070062extracellular vesicular exosome IDA19056867
    GO:0071682endocytic vesicle lumen TAS--

    HPX for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HPX About    
    See pathways by source

    SuperPathContained pathways About
    1Binding and Uptake of Ligands by Scavenger Receptors
    Binding and Uptake of Ligands by Scavenger Receptors0.53
    Scavenging of Heme from Plasma0.53

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for HPX
        Scavenging of heme from plasma



    HPX for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including HPX: 
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HPX

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    Selected Interacting proteins for HPX (P027903 ENSP000002659834) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    KCNMA1Q127913I2D: score=1 
    LGALS3P179313I2D: score=1 
    LGALS8O002143I2D: score=1 
    GLUD1ENSP000002778654STRING: ENSP00000277865
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002639positive regulation of immunoglobulin production IEA--
    GO:0002925positive regulation of humoral immune response mediated by circulating immunoglobulin IEA--
    GO:0006879cellular iron ion homeostasis TAS3855550
    GO:0015886heme transport TAS3855550
    GO:0016032viral process IEA--

    HPX for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HPX (HEMO)

    2 HMDB Compounds for HPX    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    IronArmco iron (see all 19)7439-89-6--

    1 DrugBank Compound for HPX    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Heme-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for HPX gene (see all 31)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    haem 58.9 8 17712531 (2), 11563695 (1), 15697212 (1), 9588949 (1) (see all 5)
    apotransferrin 57.8 1 15507294 (1)
    iron 49.8 31 8262649 (5), 2380200 (3), 7768617 (2), 12468596 (1) (see all 16)
    hepa 44.7 1 1964416 (1)
    porphyrin 42.4 3 10737728 (1), 7768617 (1), 7671136 (1)
    cyanide 34.1 1 8087243 (1)
    fibrinogen 31 18 9061799 (4), 17786358 (1), 10199063 (1), 14586134 (1) (see all 8)
    hydroxamate 29.9 2 12475252 (1)
    histidine 25.8 5 7681064 (2), 8692902 (1), 1988069 (1), 8078898 (1)
    fe3+ 22.9 2 8855948 (1)



    HPX for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HPX gene: 
    NM_000613.2  

    Unigene Cluster for HPX:

    Hemopexin
    Hs.426485  [show with all ESTs]
    Unigene Representative Sequence: NM_000613
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265983(uc001mdg.2 uc009yfc.2) ENST00000527556 ENST00000529037
    ENST00000533561 ENST00000534429 ENST00000529775 ENST00000525057 ENST00000533369
    ENST00000533856 ENST00000528348(uc010rai.1) ENST00000534800 ENST00000527105

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HPX using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate HPX:
    hsa-miR-3185
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HPX
    Predesigned siRNA for gene silencing in human, mouse, rat HPX
    Clone
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    OriGene clones in human, mouse for HPX (see all 7)
    OriGene ORF clones in mouse, rat for HPX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HPX (NM_000613)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HPX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HPX
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HPX
    OriGene qSTAR qPCR primer pairs in human, mouse for HPX
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HPX
      QuantiTect SYBR Green Assays in human, mouse, rat HPX
      QuantiFast Probe-based Assays in human, mouse, rat HPX

    Additional mRNA sequence: 

    AK303758.1 AK313648.1 BC005395.1 J03048.1 X02537.1 

    12 DOTS entries:

    DT.452528  DT.92438663  DT.92438665  DT.120715441  DT.100816455  DT.120715437  DT.100816468  DT.100816466 
    DT.100816469  DT.120715433  DT.95073745  DT.120715439 

    Selected AceView cDNA sequences (see all 287):

    AV647992 AV653147 AV655898 AV650721 BG563236 J03048 T40186 CB120347 
    AA345285 AV653488 BX496061 AV661453 AV655253 AA343390 AV652412 CB120320 
    R16569 AV651973 AL532235 R16628 BX325178 CB111971 AV655401 BM921160 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HPX (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
    SP1:                                      -                                   -     -                       -                           
    SP2:              -     -     -     -     -                                   -     -                                                   
    SP3:                                      -                                   -     -                                                   
    SP4:                    -     -     -     -                                                                                             
    SP5:                                      -                                                                                             


    ECgene alternative splicing isoforms for HPX

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HPX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTCTGGCCT
    HPX Expression
    About this image


    HPX expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Liver Lobule
             Hepatocyte-like cells
    HPX Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HPX Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.426485

    UniProtKB/Swiss-Prot: HEMO_HUMAN, P02790
    Tissue specificity: Expressed by the liver and secreted in plasma

        Pathway & Disease-focused RT2 Profiler PCR Array including HPX: 
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HPX
    OriGene qSTAR qPCR primer pairs in human, mouse for HPX
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HPX
    QuantiTect SYBR Green Assays in human, mouse, rat HPX
    QuantiFast Probe-based Assays in human, mouse, rat HPX
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HPX

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HPX gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hpx1 , 5 hemopexin1, 5 81.84(n)1
    75.49(a)1
      7 (55.91 cM)5
    154581  NM_017371.21  NP_059067.21 
     1055916135 
    chicken
    (Gallus gallus)
    Aves HPX1 hemopexin 57.66(n)
    47.84(a)
      419076  XM_417267.4  XP_417267.3 
    lizard
    (Anolis carolinensis)
    Reptilia HPX6
    hemopexin
    42(a)
    1 ↔ 1
    AAWZ02040500(707-4081)
    African clawed frog
    (Xenopus laevis)
    Amphibia CF521889.12   -- 72.73(n)    CF521889.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hpx1 hemopexin 50.65(n)
    38.59(a)
      327588  NM_001111147.1  NP_001104617.1 


    ENSEMBL Gene Tree for HPX (if available)
    TreeFam Gene Tree for HPX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HPX (see all 362)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1114333271,2
    C--6115717(+) CTAGGTA/-TATAT 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs1834279211,2
    --6451841(+) AGCCAC/TGAGTG 1 -- ds50010--------
    rs1877492511,2
    --6451847(+) GAGTGG/TTGTTA 1 -- ds50010--------
    rs1175680551,2
    C,F--6451952(+) CCAGGC/TCCTGT 1 -- ds50011Minor allele frequency- T:0.03EA 120
    rs1906342221,2
    C--6452062(+) TCTTCC/TGACTC 1 -- ds50010--------
    rs1832983611,2
    --6452084(+) CCCCCA/C/G/
            
    ACTAT
    1 -- ds50010--------
    rs740533801,2
    C,F--6452169(+) TAGTGC/TTCCCC 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1883451201,2
    --6452263(+) TTCACA/GACCAA 1 -- ds50010--------
    rs1135956291,2
    C--6452270(+) CCAAGG/TTCCCT 1 -- ut310--------
    rs1925311661,2
    --6452348(+) ATGTCA/GGAAGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for HPX (6452268 - 6463847 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HPX: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HPX
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142290    OMIM disorders: --

    Selected diseases for HPX (see all 30):    
    About MalaCards
    blackwater fever    hepatitis e    porphyria cutanea tarda    amelogenesis imperfecta
    proteinuria    porphyria    hemolytic anemia    atherosclerosis
    type 1 diabetes mellitus    blindness    influenza    laryngitis
    type 1 diabetes    arthritis    liver disease    diabetes mellitus
    hepatocellular carcinoma    schizophrenia    pancreatic cancer    alzheimer's disease


    HPX for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for HPX gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hemolysis intravascular 76.8 7 18556779 (2), 11580905 (2), 20386613 (1), 12805012 (1) (see all 5)
    hemolysis 50.7 11 11580905 (2), 20074563 (1), 2093885 (1), 19039664 (1) (see all 8)
    proteinuria 22.5 3 2253403 (1), 18753258 (1)
    inflammation 22.5 6 15038107 (1), 10504726 (1), 14586134 (1), 17185359 (1) (see all 6)
    anemia hemolytic 18.4 1 11580905 (1)
    atherosclerosis 12.6 2 15236792 (1), 2132529 (1)
    preeclampsia 1.55 4 17469012 (2), 19414647 (2)
    rheumatoid arthritis 1.11 1 15038107 (1)
    bleeding 0 1 8201257 (1)
    necrosis 0 4 11699640 (3), 15113099 (1)

    Genetic Association Database (GAD): HPX
    Human Genome Epidemiology (HuGE) Navigator: HPX (3 documents)

    Export disorders for HPX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HPX gene, integrated from 10 sources (see all 256):
    (articles sorted by number of sources associating them with HPX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of the human hemopexin gene and evidence for intron- mediated evolution. (PubMed id 2842511)1, 2, 3 Altruda F.... Silengo L. (J. Mol. Evol. 1988)
    2. The primary structure of human hemopexin deduced from cDNA sequence: evidence for internal, repeating homology. (PubMed id 2989777)1, 2, 3 Altruda F.... Silengo L. (Nucleic Acids Res. 1985)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Kinetics and specificity of feline leukemia virus subgroup C receptor (FLVCR) export function and its dependence on hemopexin. (PubMed id 20610401)1, 2 Yang Z.... Abkowitz J.L. (J. Biol. Chem. 2010)
    5. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)1, 2 Ramachandran P....Loo J.A. (J. Proteome Res. 2006)
    6. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    7. Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. (PubMed id 14760718)1, 2 Bunkenborg J.... Wisniewski J.R. (Proteomics 2004)
    8. A proteomic analysis of human bile. (PubMed id 15084671)1, 2 Kristiansen T.Z.... Pandey A. (Mol. Cell. Proteomics 2004)
    9. The hemopexin gene maps to the same location as the beta-globin gene cluster on human chromosome 11. (PubMed id 3220477)1, 2 Law M.L.... Kao F.T. (Genomics 1988)
    10. Complete amino acid sequence of human hemopexin, the heme-binding protein of serum. (PubMed id 3855550)1, 2 Takahashi N.... Putnam F.W. (Proc. Natl. Acad. Sci. U.S.A. 1985)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3263 HGNC: 5171 AceView: HPX Ensembl:ENSG00000110169 euGenes: HUgn3263
    ECgene: HPX H-InvDB: HPX

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HPX Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for HPX gene:
    Search GeneIP for patents involving HPX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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