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Aliases for HPX Gene

Aliases for HPX Gene

  • Hemopexin 2 3
  • Beta-1B-Glycoprotein 3 4
  • HX 3

External Ids for HPX Gene

Summaries for HPX Gene

Entrez Gene Summary for HPX Gene

  • This gene encodes a plasma glycoprotein that binds heme with high affinity. The encoded protein is an acute phase protein that transports heme from the plasma to the liver and may be involved in protecting cells from oxidative stress. [provided by RefSeq, Apr 2009]

GeneCards Summary for HPX Gene

HPX (Hemopexin) is a Protein Coding gene. Diseases associated with HPX include blackwater fever. Among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and Binding and Uptake of Ligands by Scavenger Receptors. GO annotations related to this gene include heme transporter activity.

UniProtKB/Swiss-Prot for HPX Gene

  • Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation

Gene Wiki entry for HPX Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HPX Gene

Genomics for HPX Gene

Genomic Location for HPX Gene

Start:
6,431,038 bp from pter
End:
6,442,617 bp from pter
Size:
11,580 bases
Orientation:
Minus strand

Genomic View for HPX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HPX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HPX Gene

Regulatory Elements for HPX Gene

Proteins for HPX Gene

  • Protein details for HPX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02790-HEMO_HUMAN
    Recommended name:
    Hemopexin
    Protein Accession:
    P02790
    Secondary Accessions:
    • B2R957

    Protein attributes for HPX Gene

    Size:
    462 amino acids
    Molecular mass:
    51676 Da
    Quaternary structure:
    • Interacts with HEV ORF3 protein. Interacts with FLVCR1.
    Miscellaneous:
    • The isolated N-terminal domain binds one heme. The full-length protein also binds one heme, but at a different site. The physiological significance of this is not clear (By similarity).
    SequenceCaution:
    • Sequence=CAA26382.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for HPX Gene

Proteomics data for HPX Gene at MOPED

Post-translational modifications for HPX Gene

  • N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. O-glycosylation in the 30-40 region is minor compared to glycosylation at Thr-24 and Thr-29.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Thr24, Thr29, Asn64, Asn187, Asn240, Asn246, and Asn453

Other Protein References for HPX Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HPX Gene

Domains for HPX Gene

Protein Domains for HPX Gene

Suggested Antigen Peptide Sequences for HPX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P02790

UniProtKB/Swiss-Prot:

HEMO_HUMAN
Family:
  • Belongs to the hemopexin family.:
    • P02790
Similarity:
  • Contains 8 hemopexin repeats.:
    • P02790
genes like me logo Genes that share domains with HPX: view

No data available for Gene Families for HPX Gene

Function for HPX Gene

Molecular function for HPX Gene

GENATLAS Biochemistry: hemopexin,beta 1 glycoprotein of blood serum
UniProtKB/Swiss-Prot Function: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation

Gene Ontology (GO) - Molecular Function for HPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20610401
GO:0015232 heme transporter activity TAS 3855550
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with HPX: view
genes like me logo Genes that share phenotypes with HPX: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HPX Gene

Localization for HPX Gene

Subcellular locations from UniProtKB/Swiss-Prot for HPX Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HPX Gene COMPARTMENTS Subcellular localization image for HPX gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
GO:0070062 extracellular exosome IDA 19056867
GO:0071682 endocytic vesicle lumen TAS --
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with HPX: view

Pathways for HPX Gene

genes like me logo Genes that share pathways with HPX: view

Pathways by source for HPX Gene

Interacting Proteins for HPX Gene

Gene Ontology (GO) - Biological Process for HPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002639 positive regulation of immunoglobulin production IEA --
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin IEA --
GO:0006879 cellular iron ion homeostasis TAS 3855550
GO:0006898 receptor-mediated endocytosis TAS --
GO:0015886 heme transport TAS 3855550
genes like me logo Genes that share ontologies with HPX: view

Compounds for HPX Gene

(2) HMDB Compounds for HPX Gene

Compound Synonyms Cas Number PubMed IDs
Heme
  • (protoporphyrinato)iron
14875-96-8
Iron
  • Armco iron
7439-89-6

(1) Drugbank Compounds for HPX Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Heme
target

(31) Novoseek inferred chemical compound relationships for HPX Gene

Compound -log(P) Hits PubMed IDs
haem 58.9 6
apotransferrin 57.8 1
iron 49.8 23
hepa 44.7 1
porphyrin 42.4 3
genes like me logo Genes that share compounds with HPX: view

Transcripts for HPX Gene

Unigene Clusters for HPX Gene

Hemopexin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HPX Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: - - - -
SP2: - - - - - - -
SP3: - - -
SP4: - - - -
SP5: -
SP6:
SP7:
SP8: -
SP9:

Relevant External Links for HPX Gene

GeneLoc Exon Structure for
HPX
ECgene alternative splicing isoforms for
HPX

Expression for HPX Gene

mRNA expression in normal human tissues for HPX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HPX Gene

This gene is overexpressed in Liver (52.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HPX Gene

SOURCE GeneReport for Unigene cluster for HPX Gene Hs.426485

mRNA Expression by UniProt/SwissProt for HPX Gene

P02790-HEMO_HUMAN
Tissue specificity: Expressed by the liver and secreted in plasma
genes like me logo Genes that share expressions with HPX: view

Orthologs for HPX Gene

This gene was present in the common ancestor of chordates.

Orthologs for HPX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HPX 35
  • 99.71 (n)
  • 99.78 (a)
HPX 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HPX 35
  • 81.05 (n)
  • 73.67 (a)
HPX 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HPX 35
  • 85.95 (n)
  • 81.9 (a)
HPX 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hpx 35
  • 81.84 (n)
  • 75.49 (a)
Hpx 16
Hpx 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HPX 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HPX 36
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hpx 35
  • 82.57 (n)
  • 77.02 (a)
chicken
(Gallus gallus)
Aves HPX 35
  • 57.66 (n)
  • 47.84 (a)
HPX 36
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HPX 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495728 35
  • 54.95 (n)
  • 44.74 (a)
zebrafish
(Danio rerio)
Actinopterygii hpx 35
  • 50.65 (n)
  • 38.59 (a)
hpx 36
  • 33 (a)
OneToMany
HPX (2 of 2) 36
  • 38 (a)
OneToMany
Species with no ortholog for HPX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HPX Gene

ENSEMBL:
Gene Tree for HPX (if available)
TreeFam:
Gene Tree for HPX (if available)

Paralogs for HPX Gene

No data available for Paralogs for HPX Gene

Variants for HPX Gene

Sequence variations from dbSNP and Humsavar for HPX Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs12117 - 6,440,254(-) GGGAC(C/T)GGGAG reference, missense
rs1042547 -- 6,431,292(-) TGCTA(A/C)AGTGA stop-gained, reference
rs2035675 -- 6,441,858(+) tgacc(A/G)ccTTA upstream-variant-2KB
rs2291482 -- 6,437,023(-) CTCCC(A/C)CAATG intron-variant
rs2306895 -- 6,439,991(-) TGGGC(C/T)TGGCA intron-variant

Relevant External Links for HPX Gene

HapMap Linkage Disequilibrium report
HPX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HPX Gene

Disorders for HPX Gene

(1) MalaCards Diseases for HPX Gene

Search for HPX Gene in MalaCards »

(15) Novoseek inferred disease relationships for HPX Gene

Disease -log(P) Hits PubMed IDs
hemolysis intravascular 76.8 7
hemolysis 50.7 9
proteinuria 22.5 2
inflammation 22.5 6
anemia hemolytic 18.4 1

Relevant External Links for HPX

Genetic Association Database (GAD)
HPX
Human Genome Epidemiology (HuGE) Navigator
HPX
genes like me logo Genes that share disorders with HPX: view

No data available for UniProtKB/Swiss-Prot for HPX Gene

Publications for HPX Gene

  1. Structure of the human hemopexin gene and evidence for intron- mediated evolution. (PMID: 2842511) Altruda F. … Silengo L. (J. Mol. Evol. 1988) 2 3 4
  2. The primary structure of human hemopexin deduced from cDNA sequence: evidence for internal, repeating homology. (PMID: 2989777) Altruda F. … Silengo L. (Nucleic Acids Res. 1985) 2 3 4
  3. Complete amino acid sequence of human hemopexin, the heme-binding protein of serum. (PMID: 3855550) Takahashi N. … Putnam F.W. (Proc. Natl. Acad. Sci. U.S.A. 1985) 3 4
  4. The hemopexin gene maps to the same location as the beta-globin gene cluster on human chromosome 11. (PMID: 3220477) Law M.L. … Kao F.T. (Genomics 1988) 3 4
  5. Structure of human hemopexin: O-glycosyl and N-glycosyl sites and unusual clustering of tryptophan residues. (PMID: 6371807) Takahashi N. … Putnam F.W. (Proc. Natl. Acad. Sci. U.S.A. 1984) 3 4

Products for HPX Gene

Sources for HPX Gene

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