Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HPSE2 Gene

Aliases for HPSE2 Gene

  • Heparanase 2 (Inactive) 2 3
  • HPA2 3 4
  • Heparanase-Like Protein 3
  • Urofacial Syndrome 2
  • Heparanase 2 2
  • Heparanase 3 3
  • HPR2 3
  • UFS1 3
  • UFS 3

External Ids for HPSE2 Gene

Previous HGNC Symbols for HPSE2 Gene

  • UFS

Previous GeneCards Identifiers for HPSE2 Gene

  • GC10M099112
  • GC10M099452
  • GC10M100350
  • GC10M099883
  • GC10M100208
  • GC10M093841

Summaries for HPSE2 Gene

Entrez Gene Summary for HPSE2 Gene

  • This gene encodes a heparanase enzyme. The encoded protein is a endoglycosidase that degrades heparin sulfate proteoglycans located on the extracellular matrix and cell surface. This protein may be involved in biological processes involving remodeling of the extracellular matrix including angiogenesis and tumor progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

GeneCards Summary for HPSE2 Gene

HPSE2 (Heparanase 2 (Inactive)) is a Protein Coding gene. Diseases associated with HPSE2 include hpse2-related urofacial syndrome and urofacial syndrome 1. Among its related pathways are Proteoglycans in cancer and Metabolism. GO annotations related to this gene include heparan sulfate proteoglycan binding and heparanase activity. An important paralog of this gene is HPSE.

UniProtKB/Swiss-Prot for HPSE2 Gene

  • Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro).

Gene Wiki entry for HPSE2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HPSE2 Gene

Genomics for HPSE2 Gene

Regulatory Elements for HPSE2 Gene

Genomic Location for HPSE2 Gene

98,457,077 bp from pter
99,235,875 bp from pter
778,799 bases
Minus strand

Genomic View for HPSE2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HPSE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HPSE2 Gene

Proteins for HPSE2 Gene

  • Protein details for HPSE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inactive heparanase-2
    Protein Accession:
    Secondary Accessions:
    • Q5VUH4
    • Q5VUH5
    • Q5VUH6
    • Q8WWQ1
    • Q9HB37
    • Q9HB38
    • Q9HB39

    Protein attributes for HPSE2 Gene

    592 amino acids
    Molecular mass:
    66596 Da
    Quaternary structure:
    • Interacts with HPSE. Interacts with SDC1 (via glycan chains).

    Alternative splice isoforms for HPSE2 Gene


neXtProt entry for HPSE2 Gene

Proteomics data for HPSE2 Gene at MOPED

Post-translational modifications for HPSE2 Gene

  • Glycosylation at Asn 254 and Asn 392
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for HPSE2 Gene

Domains & Families for HPSE2 Gene

Protein Domains for HPSE2 Gene

Suggested Antigen Peptide Sequences for HPSE2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 79 family.
  • Belongs to the glycosyl hydrolase 79 family.
genes like me logo Genes that share domains with HPSE2: view

No data available for Gene Families for HPSE2 Gene

Function for HPSE2 Gene

Molecular function for HPSE2 Gene

UniProtKB/Swiss-Prot Function:
Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro).

Gene Ontology (GO) - Molecular Function for HPSE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016798 hydrolase activity, acting on glycosyl bonds --
GO:0030305 heparanase activity TAS 11027606
GO:0043395 heparan sulfate proteoglycan binding IDA 20576607
genes like me logo Genes that share ontologies with HPSE2: view

Phenotypes for HPSE2 Gene

GenomeRNAi human phenotypes for HPSE2:
genes like me logo Genes that share phenotypes with HPSE2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HPSE2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HPSE2 Gene

Localization for HPSE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HPSE2 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Jensen Localization Image for HPSE2 Gene COMPARTMENTS Subcellular localization image for HPSE2 gene
Compartment Confidence
extracellular 5
plasma membrane 4
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for HPSE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IDA 20576607
GO:0005622 intracellular TAS 11027606
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with HPSE2: view

Pathways & Interactions for HPSE2 Gene

genes like me logo Genes that share pathways with HPSE2: view

Interacting Proteins for HPSE2 Gene

Gene Ontology (GO) - Biological Process for HPSE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006027 glycosaminoglycan catabolic process TAS --
GO:0008150 biological_process ND --
GO:0008152 metabolic process --
GO:0008284 positive regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with HPSE2: view

No data available for SIGNOR curated interactions for HPSE2 Gene

Drugs & Compounds for HPSE2 Gene

(1) Additional Compounds for HPSE2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with HPSE2: view

Transcripts for HPSE2 Gene

mRNA/cDNA for HPSE2 Gene

(10) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HPSE2 Gene

Heparanase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HPSE2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HPSE2 Gene

No ASD Table

Relevant External Links for HPSE2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HPSE2 Gene

mRNA expression in normal human tissues for HPSE2 Gene

mRNA differential expression in normal tissues according to GTEx for HPSE2 Gene

This gene is overexpressed in Esophagus - Muscularis (x6.9) and Esophagus - Gastroesophageal Junction (x5.7).

Protein differential expression in normal tissues from HIPED for HPSE2 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HPSE2 Gene

SOURCE GeneReport for Unigene cluster for HPSE2 Gene Hs.500750

mRNA Expression by UniProt/SwissProt for HPSE2 Gene

Tissue specificity: Widely expressed, with the highest expression in brain, mammary gland, prostate, small intestine, testis and uterus. In the central nervous system, expressed in the spinal chord, caudate nucleus, thalamus, substantia nigra, medulla oblongata, putamen and pons. In the urinary bladder, expressed in longitudinal and circular layers of detrusor muscle. Found both in normal and cancer tissues.
genes like me logo Genes that share expression patterns with HPSE2: view

Protein tissue co-expression partners for HPSE2 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for HPSE2 Gene

Orthologs for HPSE2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HPSE2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HPSE2 35
  • 96.17 (n)
  • 98.99 (a)
(Canis familiaris)
Mammalia HPSE2 35
  • 95.33 (n)
  • 98.82 (a)
HPSE2 36
  • 97 (a)
(Mus musculus)
Mammalia Hpse2 35
  • 93.19 (n)
  • 97.47 (a)
Hpse2 16
Hpse2 36
  • 97 (a)
(Pan troglodytes)
Mammalia HPSE2 35
  • 99.72 (n)
  • 100 (a)
HPSE2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Hpse2 35
  • 89.08 (n)
  • 91.05 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 72 (a)
-- 36
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia HPSE2 36
  • 98 (a)
(Gallus gallus)
Aves HPSE2 35
  • 80.47 (n)
  • 88.14 (a)
HPSE2 36
  • 87 (a)
(Anolis carolinensis)
Reptilia HPSE2 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hpse2 35
  • 75.29 (n)
  • 83.73 (a)
(Danio rerio)
Actinopterygii hpse2 35
  • 69.96 (n)
  • 77.47 (a)
hpse2 36
  • 71 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
Species with no ortholog for HPSE2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HPSE2 Gene

Gene Tree for HPSE2 (if available)
Gene Tree for HPSE2 (if available)

Paralogs for HPSE2 Gene

Paralogs for HPSE2 Gene

(1) SIMAP similar genes for HPSE2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HPSE2: view

Variants for HPSE2 Gene

Sequence variations from dbSNP and Humsavar for HPSE2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs495451 -- 98,645,836(+) GGGGC(A/G)TGGTG intron-variant
rs495983 -- 98,514,623(-) CAGCA(A/G)TGGTC intron-variant
rs528535 -- 98,600,263(+) CTACA(C/T)GCATA intron-variant
rs528556 -- 98,652,400(+) CAACC(A/G)GTCCC intron-variant
rs529508 -- 98,541,707(+) agtct(C/T)gctga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HPSE2 Gene

Variant ID Type Subtype PubMed ID
nsv831955 CNV Gain 17160897
nsv831956 CNV Loss 17160897
nsv517710 CNV Gain+Loss 19592680
nsv520353 CNV Gain 19592680
nsv7511 CNV Loss 18451855
esv1004375 CNV Deletion 20482838
nsv7209 OTHER Inversion 18451855
esv1474285 CNV Insertion 17803354
esv23306 CNV Loss 19812545
esv25039 CNV Loss 19812545
esv2482496 CNV Deletion 19546169
esv2740017 CNV Deletion 23290073
esv2448524 OTHER Inversion 19546169
nsv436692 OTHER Inversion 17901297
nsv513014 CNV Insertion 21212237
dgv165e199 CNV Deletion 23128226
esv2740029 CNV Deletion 23290073
esv2740040 CNV Deletion 23290073
esv2674577 CNV Deletion 23128226
nsv831957 CNV Gain 17160897
nsv507573 CNV Insertion 20534489
nsv825536 CNV Loss 20364138
nsv825537 CNV Loss 20364138
nsv508602 CNV Loss 20534489
nsv7513 CNV Loss 18451855
esv32597 CNV Gain+Loss 17666407
dgv8n50 CNV Loss 21212237
esv2522473 CNV Loss 19546169
esv26720 CNV Loss 19812545
nsv498739 CNV Loss 21111241
nsv825538 CNV Loss 20364138
nsv514537 CNV Loss 21397061
nsv436820 CNV Insertion 17901297
nsv518822 CNV Gain 19592680
esv2665040 CNV Deletion 23128226
nsv521748 CNV Gain 19592680
nsv7514 CNV Loss 18451855

Variation tolerance for HPSE2 Gene

Residual Variation Intolerance Score: 41.15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.16; 51.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HPSE2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HPSE2 Gene

Disorders for HPSE2 Gene

MalaCards: The human disease database

(8) MalaCards diseases for HPSE2 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hpse2-related urofacial syndrome
  • urofacial syndrome 1
urofacial syndrome 1
  • urofacial syndrome
reproductive organ benign neoplasm
uterine benign neoplasm
endometriosis of uterus
  • uterine adenomyosis
- elite association
Search HPSE2 in MalaCards View complete list of genes associated with diseases


  • Urofacial syndrome 1 (UFS1) [MIM:236730]: A rare autosomal recessive disorder characterized by facial grimacing when attempting to smile and failure of the urinary bladder to void completely despite a lack of anatomical bladder outflow obstruction or overt neurological damage. Affected individuals often have reflux of infected urine from the bladder to the upper renal tract, with a risk of kidney damage and renal failure. {ECO:0000269 PubMed:20560209, ECO:0000269 PubMed:20560210}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for HPSE2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HPSE2: view

No data available for Genatlas for HPSE2 Gene

Publications for HPSE2 Gene

  1. Cloning and expression profiling of Hpa2, a novel mammalian heparanase family member. (PMID: 11027606) McKenzie E. … Page M. (Biochem. Biophys. Res. Commun. 2000) 2 23 67
  2. Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity. (PMID: 20576607) Levy-Adam F. … Vlodavsky I. (J. Biol. Chem. 2010) 2 67
  3. Heparanase-2 expression in normal ovarian epithelium and in benign and malignant ovarian tumors. (PMID: 19955924) de Moura J.P. … de Lima G.R. (Int. J. Gynecol. Cancer 2009) 23 67
  4. Heparanase-2 and syndecan-1 in colon cancer: the ugly ducklings or the beautiful swans? (PMID: 18528290) Giordano R.J. (Eur J Gastroenterol Hepatol 2008) 23 67
  5. Decidual heparanase activity is increased during pregnancy in the baboon (Papio anubis) and in in vitro decidualization of human stromal cells. (PMID: 17989358) D'Souza S.S. … Carson D.D. (Biol. Reprod. 2008) 23 67

Products for HPSE2 Gene

Sources for HPSE2 Gene

Back to Top