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HPSE Gene

protein-coding   GIFtS: 65
GCID: GC04M084213

Heparanase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
heparanase1 2     heparanase-12
HPA2 3 5     EC 3.2.1.1663
HSE12 3 5     Endo-glucoronidase3
HPA12 3     HEP3
HPR12 3     Heparanase-13
HPSE12 3     Hpa13
endo-glucoronidase2     

External Ids:    HGNC: 51641   Entrez Gene: 108552   Ensembl: ENSG000001730837   OMIM: 6047245   UniProtKB: Q9Y2513   

Export aliases for HPSE gene to outside databases

Previous GC identifers: GC04M084138 GC04M084507 GC04M084672 GC04M084570 GC04M084435 GC04M079959


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HPSE Gene:
Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein
encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through
remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the
extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Sep 2011)

GeneCards Summary for HPSE Gene:
HPSE (heparanase) is a protein-coding gene. Diseases associated with HPSE include gallbladder cancer, and colon adenocarcinoma. GO annotations related to this gene include beta-glucuronidase activity and protein dimerization activity. An important paralog of this gene is HPSE2.

UniProtKB/Swiss-Prot: HPSE_HUMAN, Q9Y251
Function: Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and
core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves
the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a
6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit
carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid
moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor
invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and
inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas.
Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and
activation factor VII. Increases cell adhesion to the extacellular matrix (ECM), independent of its enzymatic
activity. Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin
increases this AKT1/PKB activation. Regulates osteogenesis. Enhances angiogenesis through up-regulation of
SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair
homeostasis

summary for HPSE Gene:
Heparanases are endo beta-D-glucuronidase enzymes that cleave heparan sulfate side chains of heparan sulfate
proteoglycans on cell surfaces and the extracellular matrix. Heparanases are involved in the clotting
pathway and interact with tissue factor (TF) and TF pathway inhibitor (TFPI) to promote coagulation.
Additional physiological roles include heparan sulfate turnover, embryo development, hair growth, and wound
healing. Overexpression of heparanases is strongly implicated in tumor metastasis and angiogenesis

Gene Wiki entry for HPSE (Heparanase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the HPSE gene promoter:
         CREB   deltaCREB   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHPSE promoter sequence
   Search Chromatin IP Primers for HPSE

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HPSE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.3   Ensembl cytogenetic band:  4q21.23   HGNC cytogenetic band: 4q21.3

HPSE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HPSE gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M084213:  view genomic region     (about GC identifiers)

Start:
84,213,614 bp from pter      End:
84,256,306 bp from pter
Size:
42,693 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HPSE_HUMAN, Q9Y251 (See protein sequence)
Recommended Name: Heparanase precursor  
Size: 543 amino acids; 61149 Da
Subunit: Heterodimer; heterodimer formation between the 8 kDa and the 50 kDa subunits is required for enzyme
activity. Interacts with TF; the interaction, inhibited by heparin, enhances the generation of activated factor X
and activates coagulation. Interacts with HRG; the interaction is enhanced at acidic pH, partially inhibits
binding of HPSE to cell surface receptors and modulates its enzymatic activity. Interacts with SDC1; the
interaction enhances the shedding of SDC1. Interacts with HPSE2
Secondary accessions: A9JIG7 C7F7I3 C7F7I4 E9PCA9 E9PGR1 Q53GE5 Q9UL39
Alternative splicing: 4 isoforms:  Q9Y251-1   Q9Y251-2   Q9Y251-3   Q9Y251-4   (Escapes proteolytic cleavage, devoid of HS degradation activity)

Explore the universe of human proteins at neXtProt for HPSE: NX_Q9Y251

Explore proteomics data for HPSE at MOPED

Post-translational modifications: 

  • Proteolytically processed. The cleavage of the 65 kDa form leads to the generation of a linker peptide, and 8 kDa
    and 50 kDa products. The active form, the 8/50 kDa heterodimer, is resistant to degradation. Complete removal of
    the linker peptide appears to be a prerequisite to the complete activation of the enzyme1
  • N-glycosylated. Glycosylation of the 50 kDa subunit appears to be essential for its solubility1
  • Glycosylation2 at Asn162, Asn178, Asn200, Asn217, Asn238, Asn459
  • Modification sites at PhosphoSitePlus

  • See HPSE Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001092010.1  NP_001159970.1  NP_001186759.1  NP_006656.2  

    ENSEMBL proteins: 
     ENSP00000308107   ENSP00000384262   ENSP00000426139   ENSP00000423265   ENSP00000421038  
     ENSP00000421827   ENSP00000421365  
    Reactome Protein details: Q9Y251

    HPSE Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for HPSE (Heparanase/HPSE)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for HPSE
    OriGene Custom MassSpec
    OriGene Custom Protein Services for HPSE
    GenScript Custom Purified and Recombinant Proteins Services for HPSE
    Novus Biologicals HPSE Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for HPSE
    Browse Proteins at Cloud-Clone Corp.

    HPSE Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for HPSE
    OriGene Custom Antibody Services for HPSE
    Abcam antibodies for HPSE
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for HPSE
    LSBio Antibodies in human, mouse, rat for HPSE

    HPSE Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HPSE
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HPSE
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR017853 Glycoside_hydrolase_SF
     IPR013781 Glyco_hydro_catalytic_dom
     IPR005199 Glyco_hydro_79

    Graphical View of Domain Structure for InterPro Entry Q9Y251

    ProtoNet protein and cluster: Q9Y251

    UniProtKB/Swiss-Prot: HPSE_HUMAN, Q9Y251
    Similarity: Belongs to the glycosyl hydrolase 79 family


    HPSE for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HPSE_HUMAN, Q9Y251
    Function: Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and
    core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves
    the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a
    6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit
    carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid
    moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor
    invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and
    inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas.
    Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and
    activation factor VII. Increases cell adhesion to the extacellular matrix (ECM), independent of its enzymatic
    activity. Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin
    increases this AKT1/PKB activation. Regulates osteogenesis. Enhances angiogenesis through up-regulation of
    SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair
    homeostasis
    Catalytic activity: Endohydrolysis of (1->4)-beta-D-glycosidic bonds of heparan sulfate chains in heparan sulfate
    proteoglycan
    Enzyme regulation: Inhibited by EDTA, laminarin sulfate and, to a lower extent, by heparin and sulfamin and
    activated by calcium and magnesium (By similarity)
    Biophysicochemical properties: pH dependence: Optimum pH is 4-6;

         Genatlas biochemistry entry for HPSE:
    heparanase,widely expressed,noteworthy in placenta,platelet,spleen,smooth muscle cells,endoglyosidase cleaving
    heparan sulfate proteoglycan at a limited mumber of sites along the polysaccharide chain,essential in the
    disassembly of the extracellular matrix (ECM) by invading cells,involved in tumor invasion and metastasis

         Enzyme Number (IUBMB): EC 3.2.1.1661

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004566beta-glucuronidase activity TAS10395325
    GO:0005515protein binding IPI15292202
    GO:0016798hydrolase activity, acting on glycosyl bonds ----
    GO:0030305heparanase activity TAS--
    GO:0045545syndecan binding IDA15292202
         
    HPSE for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hpse):
     cardiovascular system  endocrine/exocrine gland  hematopoietic system  integument 

    HPSE for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Hpsetm1Jpli for HPSE

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HPSE
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HPSE

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HPSE
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HPSE

    miRNA
    Products:
        
    miRTarBase miRNAs that target HPSE:
    hsa-mir-1258 (MIRT005537)

    Block miRNA regulation of human, mouse, rat HPSE using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HPSE (see all 19):
    hsa-miR-607 hsa-miR-340 hsa-miR-500a hsa-miR-105 hsa-miR-3150b-3p hsa-miR-641 hsa-miR-205* hsa-miR-1252
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HPSE
    Predesigned siRNA for gene silencing in human, mouse, rat HPSE

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HPSE

    Clone
    Products:
         
    OriGene clones in human, mouse for HPSE (see all 15)
    OriGene ORF clones in mouse, rat for HPSE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): HPSE (NM_006665)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HPSE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HPSE

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for HPSE 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HPSE


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HPSE_HUMAN, Q9Y251: Lysosome membrane; Peripheral membrane protein. Secreted. Nucleus. Note=Proheparanase is
    secreted via vesicles of the Golgi. Interacts with cell membrane heparan sulfate proteoglycans (HSPGs).
    Endocytosed and accumulates in endosomes. Transferred to lysosomes where it is proteolytically cleaved to produce
    the active enzyme. Under certain stimuli, transferred to the cell surface. Associates with lipid rafts.
    Colocalizes with SDC1 in endosomal/lysosomal vesicles. Accumulates in perinuclear lysosomal vesicles. Heparin
    retains proheparanase in the extracellular medium (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    lysosome5
    nucleus5
    vacuole5
    golgi apparatus2
    plasma membrane2
    endosome1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005764lysosome IDA15126626
    GO:0005765lysosomal membrane IEA--

    HPSE for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HPSE About   (see all 8)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    2MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIIB - Sanfilippo syndrome B0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS II - Hunter syndrome0.45
    MPS IV - Morquio syndrome A0.45
    Glycosaminoglycan metabolism0.45
    Mucopolysaccharidoses0.45
    MPS IV - Morquio syndrome B0.45
    3Heparan sulfate/heparin (HS-GAG) metabolism
    Heparan sulfate/heparin (HS-GAG) metabolism0.57
    HS-GAG degradation0.39
    4Syndecan-1-mediated signaling events
    Syndecan-1-mediated signaling events
    5Proteoglycans in cancer
    Proteoglycans in cancer

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for HPSE
        Articular Cartilage Extracellular Matrix


    1 BioSystems Pathway for HPSE
        Syndecan-1-mediated signaling events

    1 Reactome Pathway for HPSE
        HS-GAG degradation


    3 Kegg Pathways  (Kegg details for HPSE):
        Glycosaminoglycan degradation
    Metabolic pathways
    Proteoglycans in cancer


    HPSE for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HPSE: 
              Angiogenic Growth Factors in human mouse rat
              Angiogenesis in human mouse rat
              Tumor Metastasis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HPSE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for HPSE (ENSP000003081074) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGRNENSP000003686784STRING: ENSP00000368678
    GPC1ENSP000002640394STRING: ENSP00000264039
    GPC2ENSP000002923774STRING: ENSP00000292377
    GPC3ENSP000003598544STRING: ENSP00000359854
    GPC4ENSP000003598644STRING: ENSP00000359864
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006027glycosaminoglycan catabolic process TAS--
    GO:0006029proteoglycan metabolic process TAS10446189
    GO:0007160cell-matrix adhesion IDA12773484
    GO:0010575positive regulation vascular endothelial growth factor production IDA16452201

    HPSE for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for HPSE
      Browse compounds at ApexBio 

    Compounds for HPSE available from Tocris Bioscience    About this table
    CompoundAction CAS #
    FumagillinMethionine aminopeptidase-2 inhibitor; antiangiogenic[23110-15-8]
    2-MethoxyestradiolApoptotic and antiangiogenic agent[362-07-2]
    P005091USP7 inhibitor[882257-11-6]
    Herbimycin ASrc family kinase inhibitor. Also Hsp90 inhibitor[70563-58-5]
    PX 12Competitive thioredoxin-1 inhibitor[141400-58-0]

    3 HMDB Compounds for HPSE    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    HeparinArteven (see all 17)9005-49-6--
    MagnesiumMagnesium (see all 2)7439-95-4--

    2 DrugBank Compounds for HPSE    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    HeparinAlpha-Heparin (see all 8)9005-49-6enzymesubstrate17627539 18545691 20434010 18064313 21575986 16460439
    DalteparinDaltepariininatrium (see all 13)9041-08-1enzymesubstrate16041398

    Selected Novoseek inferred chemical compound relationships for HPSE gene (see all 36)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heparan sulfate 94.9 495 9188488 (10), 16759289 (7), 18058084 (6), 17121850 (6) (see all 99)
    matrigel 67.5 7 16709798 (2), 17629853 (1), 19956890 (1), 10909416 (1) (see all 5)
    heparin 64.5 87 12415589 (7), 16460439 (6), 18220506 (3), 12837765 (3) (see all 42)
    lysolecithin 49 2 9188470 (1), 11150731 (1)
    vegf 47.6 63 16452201 (6), 15260846 (5), 12901827 (4), 18288398 (4) (see all 20)
    glycosaminoglycan 46.8 5 9487024 (1), 11387326 (1), 9381967 (1), 8665526 (1) (see all 5)
    glucosamine 46.8 2 11577085 (1), 12226079 (1)
    suramin 42.7 25 12569571 (6), 2033058 (5), 16645004 (1), 15112962 (1) (see all 6)
    polysaccharide 40.9 21 20181948 (4), 17981072 (2), 9553782 (1), 16474844 (1) (see all 17)
    d-glucuronic acid 38 2 15647251 (1)



    HPSE for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HPSE gene (4 alternative transcripts): 
    NM_001098540.2  NM_001166498.2  NM_001199830.1  NM_006665.5  

    Unigene Cluster for HPSE:

    Heparanase
    Hs.44227  [show with all ESTs]
    Unigene Representative Sequence: NM_006665
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311412(uc003hoi.3 uc003hoj.4) ENST00000405413(uc003hok.4 uc011cct.2 uc011ccq.2 uc011ccr.2 uc011ccs.2)
    ENST00000507150 ENST00000512196 ENST00000509906 ENST00000508891(uc021xpr.1)
    ENST00000513463
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HPSE using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HPSE (see all 19):
    hsa-miR-607 hsa-miR-340 hsa-miR-500a hsa-miR-105 hsa-miR-3150b-3p hsa-miR-641 hsa-miR-205* hsa-miR-1252
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HPSE
    Clone
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    OriGene clones in human, mouse for HPSE (see all 15)
    OriGene ORF clones in mouse, rat for HPSE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): HPSE (NM_006665)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HPSE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HPSE
    Primer
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    OriGene qPCR primer pairs and template standards for HPSE
    OriGene qSTAR qPCR primer pairs in human, mouse for HPSE
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HPSE
      QuantiTect SYBR Green Assays in human, mouse, rat HPSE
      QuantiFast Probe-based Assays in human, mouse, rat HPSE

    Additional mRNA sequence: 

    AF084467.1 AF144325.1 AF152376.1 AF155510.1 AF165154.1 AJ627581.1 AK075400.1 AK090910.1 
    AK222986.1 AM419200.1 AY948074.1 BC029464.1 BC051321.1 FJ517659.1 FJ517660.1 GQ337901.1 
    GQ337902.1 HM187643.1 

    4 DOTS entries:

    DT.40273673  DT.410744  DT.100018112  DT.100670965 

    Selected AceView cDNA sequences (see all 73):

    CR610536 AA583772 BQ922339 AA136989 AI582254 AI867353 AW015299 AI342512 
    BC051321 BM312247 CR604689 BQ691142 AA483286 BQ775819 AA280598 BP352325 
    BG537646 CB988510 BE045976 AL545232 AI033490 AW592554 BX107633 BC029464 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HPSE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCCCTTCA
    HPSE Expression
    About this image


    HPSE expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
     
     Blood (Hematopoietic System)
             Megakaryocytes Hematopoietic Bone Marrow
     
     Neural Tube (Nervous System)
             Mesencephalic Floor Plate
     
     Placenta (Extraembryonic Tissues)
    HPSE Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HPSE Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.44227

    UniProtKB/Swiss-Prot: HPSE_HUMAN, Q9Y251
    Tissue specificity: Highly expressed in placenta and spleen and weakly expressed in lymph node, thymus, peripheral
    blood leukocytes, bone marrow, endothelial cells, fetal liver and tumor tissues. Also expressed in hair
    follicles, specifically in both Henle's and Huxley's layers of inner the root sheath (IRS) at anagen phase

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HPSE: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HPSE gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hpse1 , 5 heparanase1, 5 80.37(n)1
    78.08(a)1
      5 (48.51 cM)5
    154421  NM_152803.41  NP_690016.11 
     1006794845 
    chicken
    (Gallus gallus)
    Aves HPSE1 heparanase 62.57(n)
    61.98(a)
      373981  NM_204167.1  NP_989498.1 
    lizard
    (Anolis carolinensis)
    Reptilia HPSE6
    heparanase
    62(a)
    1 ↔ 1
    5(43297880-43323215)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia hpse1 heparanase 61.96(n)
    57.46(a)
      100145320  NM_001126795.1  NP_001120267.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hpse1 heparanase 57.03(n)
    54.38(a)
      563020  NM_001045005.1  NP_001038470.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GUS31 GUS3 44.35(n)
    31.67(a)
      833437  NM_180762.2  NP_851093.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g01790001 Os06g0179000 44.35(n)
    35.04(a)
      4340299  NM_001063502.1  NP_001056967.1 


    ENSEMBL Gene Tree for HPSE (if available)
    TreeFam Gene Tree for HPSE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HPSE gene
    HPSE22  
    1 SIMAP similar gene for HPSE using alignment to 4 protein entries:     HPSE_HUMAN (see all proteins):
    HPSE2

    HPSE for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HPSE (see all 977)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0236004
    Some hepatocellular carcinoma4--see VAR_0236002 N S mis40--------
    rs752690361,2
    C,F--84028267(+) GCTTCC/TGGCCT 4 -- ds50011Minor allele frequency- T:0.07WA 118
    rs1895391921,2
    --84028428(+) CTGAAC/TGCTCA 4 -- ds50010--------
    rs781697081,2
    C,F--84028429(+) TGAACG/ACTCAT 4 -- ds50011Minor allele frequency- A:0.12WA 118
    rs751382841,2
    C--84028696(+) AGTCTA/GTAGGC 4 -- ds50010--------
    rs772055061,2
    C,F--84028708(+) TTACAT/CTACTA 4 -- ds50013Minor allele frequency- C:0.08NA CSA EA 124
    rs46936021,2
    C,F,A,H--84028738(+) TCAAGG/ATTATA 4 -- ut3124Minor allele frequency- A:0.26NS EA NA WA CSA 2350
    rs757056691,2
    F--84028859(+) TTAAAT/CTGAAT 4 -- ut311Minor allele frequency- C:0.03WA 118
    rs1815425121,2
    --84029079(+) TAGCTA/GTAGGT 4 -- ut310--------
    rs1171630031,2
    C,F--84029117(+) GGATGT/CTGGAG 4 -- ut311Minor allele frequency- C:0.04EA 120

    HapMap Linkage Disequilibrium report for HPSE (84213614 - 84256306 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HPSE (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1199239CNV Deletion17803354
    esv2448972CNV Deletion19546169
    esv1009126CNV Deletion20482838
    esv2600138CNV Deletion19546169
    esv2727902CNV Deletion23290073
    esv2180695CNV Deletion18987734
    esv4639CNV Deletion18987735
    esv2667959CNV Deletion23128226
    esv2727903CNV Deletion23290073
    nsv526041CNV Loss19592680

    Human Gene Mutation Database (HGMD): HPSE
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HPSE
    DNA2.0 Custom Variant and Variant Library Synthesis for HPSE

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604724    OMIM disorders: --

    Selected diseases for HPSE (see all 91):    
    About MalaCards
    gallbladder cancer    colon adenocarcinoma    nephrosis    ethmoid sinusitis
    nevoid basal cell carcinoma syndrome    periapical granuloma    tongue cancer    proteinuria
    estrogen-receptor positive breast cancer    aortic aneurysm    malignant mesothelioma    ductal carcinoma in situ
    nephrotic syndrome    esophagitis    diabetic nephropathy    basal cell carcinoma
    adrenocortical carcinoma    embryonal rhabdomyosarcoma    sinusitis    morquio syndrome b

    1 disease from the University of Copenhagen DISEASES database for HPSE:
    Melanoma

    HPSE for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for HPSE gene (see all 71)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 76.6 304 12609066 (6), 15761980 (5), 15334632 (4), 18390199 (4) (see all 99)
    tumors 64.2 502 15837740 (7), 14695190 (6), 16217746 (5), 17347152 (5) (see all 99)
    cancer 59.6 182 11406531 (3), 16890383 (3), 18661344 (3), 11215206 (3) (see all 99)
    metastatic cancer 56.2 14 12584571 (2), 16408800 (1), 15368349 (1), 14630925 (1) (see all 10)
    melanoma 53.3 96 16288472 (5), 19115257 (4), 2351486 (4), 15368349 (4) (see all 33)
    metastatic melanoma 44.9 8 15645118 (3), 16867222 (2), 15796387 (1), 2033058 (1) (see all 5)
    neovascularization 43.9 10 11547900 (1), 11530216 (1), 17041566 (1), 12904690 (1) (see all 10)
    breast carcinoma 43 28 17030350 (3), 12219030 (3), 17634531 (3), 14695198 (2) (see all 13)
    inflammation 42 43 15279603 (2), 11406531 (1), 17952066 (1), 19244131 (1) (see all 36)
    pathological processes 40.2 7 11387326 (1), 17095861 (1), 18528290 (1), 11123890 (1) (see all 7)

    Genetic Association Database (GAD): HPSE
    Human Genome Epidemiology (HuGE) Navigator: HPSE (7 documents)

    Export disorders for HPSE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HPSE gene, integrated from 10 sources (see all 529):
    (articles sorted by number of sources associating them with HPSE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis. (PubMed id 10395326)1, 2, 3, 9 Hulett M.D....Parish C.R. (Nat. Med. 1999)
    2. Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis. (PubMed id 10395325)1, 2, 3, 9 Vlodavsky I.... Pecker I. (Nat. Med. 1999)
    3. Processing and activation of latent heparanase occurs in lysosomes. (PubMed id 15126626)1, 2, 9 Zetser A.... Ilan N. (J. Cell Sci. 2004)
    4. Heparanase procoagulant effects and inhibition by heparins. (PubMed id 20434010)1, 7, 9 Nadir Y. and Brenner B. (Thromb. Res. 2010)
    5. Inverse correlation between HPSE gene single nucleotide polymorphisms and heparanase expression: possibility of multiple levels of heparanase regulation. (PubMed id 19406828)1, 4, 9 Ostrovsky O....Nagler A. (J. Leukoc. Biol. 2009)
    6. Heparanase induces vascular endothelial growth factor expression: correlation with p38 phosphorylation levels and Src activation. (PubMed id 16452201)1, 2, 9 Zetser A....Ilan N. (Cancer Res. 2006)
    7. Heparanase 1: a key participant of inner root sheath differentiation program and hair follicle homeostasis. (PubMed id 18557927)1, 2, 9 Malgouries S.... Bernard B.A. (Exp. Dermatol. 2008)
    8. Heparanase uptake is mediated by cell membrane heparan sulfate proteoglycans. (PubMed id 15292202)1, 2, 9 Gingis-Velitski S.... Ilan N. (J. Biol. Chem. 2004)
    9. Activation, processing and trafficking of extracellular heparanase by primary human fibroblasts. (PubMed id 11973358)1, 2, 9 Nadav L.... Katz B.Z. (J. Cell Sci. 2002)
    10. Identification and characterization of heparin/heparan sulfate binding domains of the endoglycosidase heparanase. (PubMed id 15760902)1, 2, 9 Levy-Adam F.... Ilan N. (J. Biol. Chem. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10855 HGNC: 5164 AceView: HPSE Ensembl:ENSG00000173083 euGenes: HUgn10855
    ECgene: HPSE Kegg: 10855 H-InvDB: HPSE

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HPSE Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HPSE Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HPSE gene:
    Search GeneIP for patents involving HPSE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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