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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HPSE Gene

protein-coding   GIFtS: 65
GCID: GC04M084213

heparanase
 Explore 97 diseases affiliated with
HPSE via
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 Human Malady Compendium 
Biological research products
for HPSE    

Aliases
for HPSE gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Heparanase1     Heparanase-13
HPA1 2 3 5     EC 3.2.1.1663
HSE11 2 3 5     Endo-Glucoronidase1
HPSE11 2 3     HEP3
HPA12 3     Heparanase-13
HPR12 3     Hpa13
Endo-Glucoronidase1     

External Ids:    HGNC: 51641   Entrez Gene: 108552   Ensembl: ENSG000001730837   OMIM: 6047245   UniProtKB: Q9Y2513   

Export aliases for HPSE gene to outside databases

Previous GC identifers: GC04M084138 GC04M084507 GC04M084672 GC04M084570 GC04M084435 GC04M079959


Summaries
for HPSE gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HPSE:
Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein
encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through
remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the
extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. (provided
by RefSeq, Sep 2011)

UniProtKB/Swiss-Prot: HPSE_HUMAN, Q9Y251
Function: Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core
proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage
between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can
also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but
not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at
neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes.
Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans,
and increases endothelial invasion and angiogenesis in myelomas. Acts as procoagulant by increasing the generation of
activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the
extacellular matrix (ECM), independent of its enzymatic activity. Induces AKT1/PKB phosphorylation via lipid rafts
increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. Regulates osteogenesis. Enhances
angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath
differentiation and hair homeostasis

summary for HPSE:
Heparanases are endo beta-D-glucuronidase enzymes that cleave heparan sulfate side chains of heparan sulfate
proteoglycans on cell surfaces and the extracellular matrix. Heparanases are involved in the clotting
pathway and interact with tissue factor (TF) and TF pathway inhibitor (TFPI) to promote coagulation.
Additional physiological roles include heparan sulfate turnover, embryo development, hair growth, and wound
healing. Overexpression of heparanases is strongly implicated in tumor metastasis and angiogenesis

Gene Wiki entry for HPSE (Heparanase)


Genomic Views
for HPSE gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HPSE gene promoter:
         CREB   deltaCREB   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HPSE promoter sequence
   Search SABiosciences Chromatin IP Primers for HPSE

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HPSE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.3   Ensembl cytogenetic band:  4q21.23   HGNC cytogenetic band: 4q21.3

HPSE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HPSE gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M084213:  view genomic region     (about GC identifiers)

Start:
 84,213,614 bp from pter      End:
 84,256,306 bp from pter
Size:
 42,693 bases      Orientation:
 minus strand

Proteins
for HPSE gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HPSE_HUMAN, Q9Y251 (See protein sequence)
Recommended Name: Heparanase precursor  
Size: 543 amino acids; 61149 Da
Subunit: Heterodimer; heterodimer formation between the 8 kDa and the 50 kDa subunits is required for enzyme activity.
Interacts with TF; the interaction, inhibited by heparin, enhances the generation of activated factor X and activates
coagulation. Interacts with HRG; the interaction is enhanced at acidic pH, partially inhibits binding of HPSE to cell
surface receptors and modulates its enzymatic activity. Interacts with SDC1; the interaction enhances the shedding of
SDC1. Interacts with HPSE2
Subcellular location: Lysosome membrane; Peripheral membrane protein. Secreted. Nucleus. Note=Proheparanase is secreted
via vesicles of the Golgi. Interacts with cell membrane heparan sulfate proteoglycans (HSPGs). Endocytosed and
accumulates in endosomes. Transferred to lysosomes where it is proteolytically cleaved to produce the active enzyme.
Under certain stimuli, transferred to the cell surface. Associates with lipid rafts. Colocalizes with SDC1 in
endosomal/lysosomal vesicles. Accumulates in perinuclear lysosomal vesicles. Heparin retains proheparanase in the
extracellular medium (By similarity)
Secondary accessions: A9JIG7 C7F7I3 E9PCA9 E9PGR1 Q53GE5 Q9UL39
Alternative splicing: 3 isoforms:  Q9Y251-1   Q9Y251-2   Q9Y251-3   (Escapes proteolytic cleavage, devoid of HS degradation activity)

Explore the universe of human proteins at neXtProt for HPSE: NX_Q9Y251

Post-translational modifications:

  • Proteolytically processed. The cleavage of the 65 kDa form leads to the generation of a linker peptide, and 8 kDa and
    • 50 kDa products. The active form, the 8/50 kDa heterodimer, is resistant to degradation. Complete removal of the
    linker peptide appears to be a prerequisite to the complete activation of the enzyme1
  • N-glycosylated. Glycosylation of the 50 kDa subunit appears to be essential for its solubility1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y251

    • HPSE Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001092010.1  NP_001159970.1  NP_001186759.1  NP_006656.2  

    ENSEMBL proteins: 
     ENSP00000308107   ENSP00000384262   ENSP00000426139   ENSP00000423265   ENSP00000421038  
     ENSP00000421827   ENSP00000421365  
    Reactome Protein details: Q9Y251
    Human Recombinant Protein Products: 
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    R&D Systems Recombinant & Natural Proteins for HPSE (Heparanase/HPSE)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate (see all 3): HPSE
    OriGene Custom Protein Services for HPSE 
    GenScript Custom Purified and Recombinant Proteins Services for HPSE
    Novus Biologicals HPSE Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for HPSE
    Uscn Proteins for HPSE

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005634nucleus IDA--
    GO:0005764lysosome IDA15126626
    GO:0005765lysosomal membrane IEA--
    GO:0016020membrane ----


    HPSE for ontologies           About GeneDecksing



    HPSE Antibody Products: 
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    ThermoFisher Antibodies for HPSE

    Assay Products for HPSE: 
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    Uscn ELISAs and CLIAs for HPSE

    Protein Domains /
    Families
    for HPSE gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HPSE for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR017853 Glycoside_hydrolase_SF
     IPR013781 Glyco_hydro_catalytic_dom
     IPR005199 Glyco_hydro_79

    Graphical View of Domain Structure for InterPro Entry Q9Y251

    ProtoNet protein and cluster: Q9Y251

    UniProtKB/Swiss-Prot: HPSE_HUMAN, Q9Y251
    Similarity: Belongs to the glycosyl hydrolase 79 family


    Function
    for HPSE gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HPSE_HUMAN, Q9Y251
    Function: Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core
    proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage
    between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can
    also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but
    not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at
    neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes.
    Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans,
    and increases endothelial invasion and angiogenesis in myelomas. Acts as procoagulant by increasing the generation of
    activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the
    extacellular matrix (ECM), independent of its enzymatic activity. Induces AKT1/PKB phosphorylation via lipid rafts
    increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. Regulates osteogenesis. Enhances
    angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath
    differentiation and hair homeostasis
    Catalytic activity: Endohydrolysis of (1->4)-beta-D-glycosidic bonds of heparan sulfate chains in heparan sulfate
    proteoglycan
    Enzyme regulation: Inhibited by EDTA, laminarin sulfate and, to a lower extent, by heparin and sulfamin and activated
    by calcium and magnesium (By similarity)
    Biophysicochemical properties: pH dependence: Optimum pH is 4-6;

         Genatlas biochemistry entry for HPSE:
    heparanase,widely expressed,noteworthy in placenta,platelet,spleen,smooth muscle cells,endoglyosidase cleaving heparan
    sulfate proteoglycan at a limited mumber of sites along the polysaccharide chain,essential in the disassembly of the
    extracellular matrix (ECM) by invading cells,involved in tumor invasion and metastasis

    Enzyme Number (IUBMB): EC 3.2.1.1661

    miRNA
    Products:            		miRTarBase miRNAs that target HPSE:
    hsa-mir-1258 (MIRT005537)

    Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HPSE
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate HPSE (see all 19):
    hsa-miR-607 hsa-miR-340 hsa-miR-500a hsa-miR-105 hsa-miR-3150b-3p hsa-miR-641 hsa-miR-205* hsa-miR-1252
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HPSE (see all 7)
    OriGene shRNA RFP: HPSE
    OriGene siRNA: HPSE
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HPSE

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HPSE

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HPSE (see all 5)
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    Cell Line
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    Search LifeMap BioReagents cell lines for HPSE

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HPSE

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004566beta-glucuronidase activity TAS10395325
    GO:0005515protein binding IPI--
    GO:0016798hydrolase activity, acting on glycosyl bonds ----
    GO:0030305heparanase activity TAS--
    GO:0043169cation binding IEA--


    HPSE for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Hpsetm1Jpli for HPSE
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Hpse):
     cardiovascular system  endocrine/exocrine gland  hematopoietic system  integument 

    HPSE for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HPSE gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1MPS IIIC - Sanfilippo syndrome C
    8/15 pathways (see all 15)
    		MPS VI - Maroteaux-Lamy syndrome1.00
    		MPS IIIA - Sanfilippo syndrome A1.00
    		MPS IIIC - Sanfilippo syndrome C1.00
    		MPS IIID - Sanfilippo syndrome D1.00
    		MPS I - Hurler syndrome1.00
    		MPS IX - Natowicz syndrome1.00
    		Mucopolysaccharidoses1.00
    		MPS II - Hunter syndrome1.00
    2Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    3Disease
    		Disease1.00
    4Articular Cartilage Extracellular Matrix
    		Articular Cartilage Extracellular Matrix1.00
    5Syndecan-1-mediated signaling events
    		Syndecan-1-mediated signaling events1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 R&D Systems Pathway for HPSE
        Articular Cartilage Extracellular Matrix


    1 BioSystems Pathway for HPSE 
        Syndecan-1-mediated signaling events

    5/18        Reactome Pathways for HPSE (see all 18)
        MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Disease
    MPS II - Hunter syndrome
    MPS IIIA - Sanfilippo syndrome A


    2         Kegg Pathways  (Kegg details for HPSE):
        Glycosaminoglycan degradation
    Metabolic pathways


    HPSE for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HPSE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/14 Interacting proteins for HPSE (ENSP000003081074) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGRNENSP000003686784STRING: ENSP00000368678
    GPC1ENSP000002640394STRING: ENSP00000264039
    GPC2ENSP000002923774STRING: ENSP00000292377
    GPC3ENSP000003598544STRING: ENSP00000359854
    GPC4ENSP000003598644STRING: ENSP00000359864
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006027glycosaminoglycan catabolic process TAS--
    GO:0006029proteoglycan metabolic process TAS10446189
    GO:0007160cell-matrix adhesion IDA12773484
    GO:0010575positive regulation vascular endothelial growth factor production IDA16452201


    HPSE for ontologies           About GeneDecksing



    Drugs & Compounds
    for HPSE gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HPSE for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for HPSE

    Compounds for HPSE available from Tocris Bioscience    About this table
    CompoundAction CAS #
    OGT 2115Antiangiogenic. Heparanase inhibitor[853929-59-6]

    3 HMDB Compounds for HPSE    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    HeparinArteven (see all 17)9005-49-6--
    MagnesiumMagnesium (see all 2)7439-95-4--

    2 DrugBank Compounds for HPSE    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    HeparinAlpha-Heparin (see all 8)9005-49-6enzymesubstrate17627539 18545691 20434010 18064313 21575986 16460439
    DalteparinDaltepariininatrium (see all 13)9041-08-1enzymesubstrate16041398

    10/36 Novoseek chemical compound relationships for HPSE gene (see all 36)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heparan sulfate 94.9 495 9188488 (10), 16759289 (7), 18058084 (6), 17121850 (6) (see all 99)
    matrigel 67.5 7 16709798 (2), 17629853 (1), 19956890 (1), 10909416 (1) (see all 5)
    heparin 64.5 87 12415589 (7), 16460439 (6), 18220506 (3), 12837765 (3) (see all 42)
    lysolecithin 49 2 9188470 (1), 11150731 (1)
    vegf 47.6 63 16452201 (6), 15260846 (5), 12901827 (4), 18288398 (4) (see all 20)
    glycosaminoglycan 46.8 5 9487024 (1), 11387326 (1), 9381967 (1), 8665526 (1) (see all 5)
    glucosamine 46.8 2 11577085 (1), 12226079 (1)
    suramin 42.7 25 12569571 (6), 2033058 (5), 16645004 (1), 15112962 (1) (see all 6)
    polysaccharide 40.9 21 20181948 (4), 17981072 (2), 9553782 (1), 16474844 (1) (see all 17)
    d-glucuronic acid 38 2 15647251 (1)

    Search CenterWatch for drugs/clinical trials and news about HPSE 

    Transcripts
    for HPSE gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HPSE gene (4 alternative transcripts): 
    NM_001098540.2  NM_001166498.2  NM_001199830.1  NM_006665.5  

    Unigene Cluster for HPSE:

    Heparanase
    Hs.44227  [show with all ESTs]
    Unigene Representative Sequence: NM_006665
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311412(uc003hoi.3 uc003hoj.4) ENST00000405413(uc003hok.4 uc011cct.2 uc011ccq.2 uc011ccr.2 uc011ccs.2)
    ENST00000507150 ENST00000512196 ENST00000509906 ENST00000508891(uc021xpr.1)
    ENST00000513463

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HPSE
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate HPSE (see all 19):
    hsa-miR-607 hsa-miR-340 hsa-miR-500a hsa-miR-105 hsa-miR-3150b-3p hsa-miR-641 hsa-miR-205* hsa-miR-1252
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HPSE (see all 7)
    OriGene shRNA RFP: HPSE
    OriGene siRNA: HPSE
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HPSE
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HPSE (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HPSE (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): HPSE (NM_006665)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HPSE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HPSE 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HPSE
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HPSE
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HPSE
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HPSE

    Additional cDNA sequence: 

    AF084467.1 AF144325.1 AF152376.1 AF155510.1 AF165154.1 AJ627581.1 AK075400.1 AK090910.1 
    AK222986.1 AM419200.1 AY948074.1 BC029464.1 BC051321.1 FJ517659.1 FJ517660.1 GQ337901.1 
    GQ337902.1 HM187643.1 

    4 DOTS entries:

    DT.40273673  DT.410744  DT.100018112  DT.100670965 

    24/73 AceView cDNA sequences (see all 73):

    AA136989 BC051321 CR610536 AA483286 BQ691142 AI342512 AW015299 CR604689 
    BQ775819 AI582254 BQ922339 AI867353 AA583772 BM312247 CD692121 AL552151 
    BE045976 BF057628 BM312346 AI027968 BX107633 AA604873 BM996417 BF197674 

    GeneLoc Exon Structure


    Expression
    for HPSE gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HPSE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGCCCCTTCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HPSE expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HPSE Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HPSE

    SOURCE GeneReport for Unigene cluster: Hs.44227

    UniProtKB/Swiss-Prot: HPSE_HUMAN, Q9Y251
    Tissue specificity: Highly expressed in placenta and spleen and weakly expressed in lymph node, thymus, peripheral
    blood leukocytes, bone marrow, endothelial cells, fetal liver and tumor tissues. Also expressed in hair follicles,
    specifically in both Henle's and Huxley's layers of inner the root sheath (IRS) at anagen phase

        SABiosciences Expression via Pathway-Focused PCR Arrays including HPSE: 
              Angiogenic Growth Factors in human mouse rat
              Angiogenesis in human mouse rat
              Tumor Metastasis in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HPSE
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    In Situ
    Assay Products:     
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    Orthologs
    for HPSE gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HPSE gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves HPSE1 heparanase 62.89(n)
    62.23(a)    		   373981  NM_204167.1  NP_989498.1 
    lizard
    (Anolis carolinensis)    		 Reptilia HPSE6
    		 --
    		 63(a)
    		 1 ↔ 1
    		 5(43297880-43323215)
    zebrafish
    (Danio rerio)    		 Actinopterygii hpse1 heparanase 56.96(n)
    54.38(a)    		   563020  NM_001045005.1  NP_001038470.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    --
    		 --
    		 30(a)
    24(a)
    		 many ↔ many
    many ↔ many
    		 Group15.9(21032-23676)
    Group15.9(21032-24730)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AtGUS26
    AtGUS16
    (see all 3)    		 Heparanase-like protein 2
    (see all 3)    		 27(a)
    25(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 5(2503323-2506688)
    5(24632154-24635303)
    rice
    (Oryza sativa)    		 Liliopsida Os03g02117001 hypothetical protein 41.64(n)
    31.44(a)    		   4332033  NM_001055885.1  NP_001049350.1 


    ENSEMBL Gene Tree for HPSE (if available)
    TreeFam Gene Tree for HPSE (if available) 

    Paralogs
    for HPSE gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HPSE gene
    HPSE22  
    1 SIMAP similar gene for HPSE using alignment to 5 protein entries:     HPSE_HUMAN (see all proteins):
    HPSE2

    HPSE for paralogs           About GeneDecksing



    Genomic Variants
    for HPSE gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 8 variations for HPSE
         8 Indels: 40652 98775 41782 46703 12480 62224 12481 27728
    Human Gene Mutation Database (HGMD): HPSE
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HPSE
    DNA2.0 Custom Variant and Variant Library Synthesis for HPSE

    Disorders / Diseases
    for HPSE gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HPSE for disorders           About GeneDecksing

    OMIM gene information: 604724    OMIM disorders: --

    20/97 diseases for HPSE (see all 97):    About MalaCards
    estrogen-receptor positive breast cancer    nevoid basal cell carcinoma syndrome    dna topoisomerase i    aortic aneurysm
    abdominal aortic aneurysm    ethmoid sinusitis    squamous cell carcinoma    basal cell carcinoma
    malignant mesothelioma    lichen planus    nephrosis    laryngeal squamous cell carcinoma
    myocardial infarction    oral squamous cell carcinoma    carcinoma    acute myocardial infarction
    esophageal squamous cell carcinoma    nephrotic syndrome    benign tumors    pancreatic ductal adenocarcinoma

    10/71 Novoseek disease relationships for HPSE gene (see all 71)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 76.6 304 12609066 (6), 15761980 (5), 15334632 (4), 18390199 (4) (see all 99)
    tumors 64.2 502 15837740 (7), 14695190 (6), 16217746 (5), 17347152 (5) (see all 99)
    cancer 59.6 182 11406531 (3), 16890383 (3), 18661344 (3), 11215206 (3) (see all 99)
    metastatic cancer 56.2 14 12584571 (2), 16408800 (1), 15368349 (1), 14630925 (1) (see all 10)
    melanoma 53.3 96 16288472 (5), 19115257 (4), 2351486 (4), 15368349 (4) (see all 33)
    metastatic melanoma 44.9 8 15645118 (3), 16867222 (2), 15796387 (1), 2033058 (1) (see all 5)
    neovascularization 43.9 10 11547900 (1), 11530216 (1), 17041566 (1), 12904690 (1) (see all 10)
    breast carcinoma 43 28 17030350 (3), 12219030 (3), 17634531 (3), 14695198 (2) (see all 13)
    inflammation 42 43 15279603 (2), 11406531 (1), 17952066 (1), 19244131 (1) (see all 36)
    pathological processes 40.2 7 11387326 (1), 17095861 (1), 18528290 (1), 11123890 (1) (see all 7)

    Genetic Association Database (GAD): HPSE
    Human Genome Epidemiology (HuGE) Navigator: HPSE (7 documents)

    Export disorders for HPSE gene to outside databases

    Publications
    for HPSE gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HPSE gene, integrated from 9 sources (see all 502):
    (articles sorted by number of sources associating them with HPSE)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis. (PubMed id 10395326)1, 2, 3, 9 Hulett M.D....Parish C.R. (1999)
    2. Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis. (PubMed id 10395325)1, 2, 3, 9 Vlodavsky I.... Pecker I. (1999)
    3. Processing and activation of latent heparanase occurs in lysosomes. (PubMed id 15126626)1, 2, 9 Zetser A....Ilan N. (2004)
    4. Heparanase procoagulant effects and inhibition by hep arins. (PubMed id 20434010)1, 7, 9 Nadir Y. and Brenner B. (2010)
    5. Heparanase induces vascular endothelial growth factor expression: correlation with p38 phosphorylation levels and Src activation. (PubMed id 16452201)1, 2, 9 Zetser A....Ilan N. (2006)
    6. Heparanase 1: a key participant of inner root sheath differentiation program and hair follicle homeostasis. (PubMed id 18557927)1, 2, 9 Malgouries S....Bernard B.A. (2008)
    7. Heparanase uptake is mediated by cell membrane heparan sulfate proteoglycans. (PubMed id 15292202)1, 2, 9 Gingis-Velitski S.... Ilan N. (2004)
    8. Activation, processing and trafficking of extracellular heparanase by primary human fibroblasts. (PubMed id 11973358)1, 2, 9 Nadav L....Katz B.Z. (2002)
    9. Identification and characterization of heparin/heparan sulfate binding domains of the endoglycosidase heparanase. (PubMed id 15760902)1, 2, 9 Levy-Adam F.... Ilan N. (2005)
    10. Heparanase facilitates cell adhesion and spreading by clustering of cell surface heparan sulfate proteoglycans. (PubMed id 18545691)1, 7, 9 Levy-Adam F....Ilan N. (2008)

    External Searches for HPSE gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HPSE gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10855 HGNC: 5164 AceView: HPSE Ensembl:ENSG00000173083 euGenes: HUgn10855
    ECgene: HPSE Kegg: 10855 H-InvDB: HPSE

    Other Databases showing HPSE gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HPSE gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HPSE Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HPSE Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for HPSE gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HPSE gene:
    Search GeneIP for patents involving HPSE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for HPSE gene

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    Advanced Cell Diagnostics
    About This Section

     
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