Aliases for HPSE Gene
Aliases for HPSE Gene
External Ids for HPSE Gene
- HGNC: 5164
- Entrez Gene: 10855
- Ensembl: ENSG00000173083
- OMIM: 604724
- UniProtKB: Q9Y251
Previous GeneCards Identifiers for HPSE Gene
- GC04M084138
- GC04M084507
- GC04M084672
- GC04M084570
- GC04M084435
- GC04M084213
- GC04M079959
Summaries for HPSE Gene
-
Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
GeneCards Summary for HPSE Gene
HPSE (Heparanase) is a Protein Coding gene. Diseases associated with HPSE include Israeli Tick Typhus and Urofacial Syndrome 1. Among its related pathways are Innate Immune System and Glycosaminoglycan degradation. GO annotations related to this gene include protein dimerization activity and syndecan binding. An important paralog of this gene is HPSE2.
UniProtKB/Swiss-Prot for HPSE Gene
-
Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the extacellular matrix (ECM), independent of its enzymatic activity. Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. Regulates osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis.
-
Antiangiogenic agents are compounds which prevent angiogenesis in vitro and/or in vivo. Angiogenesis inhibitors may be endogenous or synthetic; others are obtained from diet, for example resveratrol.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HPSE Gene
Genomics for HPSE Gene
Regulatory Elements for HPSE Gene
Enhancers for HPSE Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HPSE on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HPSE gene promoter:
Regulatory Element Products
Genomic Location for HPSE Gene
- Chromosome:
- 4
- Start:
- 83,292,461 bp from pter
- End:
- 83,335,153 bp from pter
- Size:
- 42,693 bases
- Orientation:
- Minus strand
Genomic View for HPSE Gene
Genes around HPSE on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q21.23 by Ensembl
- 4q21.23 by Entrez Gene
- 4q21.23 by HGNC
HPSE Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HPSE Gene
Proteins for HPSE Gene
-
Protein details for HPSE Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y251-HPSE_HUMAN
- Recommended name:
- Heparanase
- Protein Accession:
- Q9Y251
- A9JIG7
- C7F7I3
- C7F7I4
- E9PCA9
- E9PGR1
- Q53GE5
- Q9UL39
Protein attributes for HPSE Gene
- Size:
- 543 amino acids
- Molecular mass:
- 61149 Da
- Quaternary structure:
-
- Heterodimer; heterodimer formation between the 8 kDa and the 50 kDa subunits is required for enzyme activity. Interacts with TF; the interaction, inhibited by heparin, enhances the generation of activated factor X and activates coagulation. Interacts with HRG; the interaction is enhanced at acidic pH, partially inhibits binding of HPSE to cell surface receptors and modulates its enzymatic activity. Interacts with SDC1; the interaction enhances the shedding of SDC1. Interacts with HPSE2.
Three dimensional structures from OCA and Proteopedia for HPSE Gene
Protein Expression for HPSE Gene
Post-translational modifications for HPSE Gene
- N-glycosylated. Glycosylation of the 50 kDa subunit appears to be essential for its solubility.
- Proteolytically processed. The cleavage of the 65 kDa form leads to the generation of a linker peptide, and 8 kDa and 50 kDa products. The active form, the 8/50 kDa heterodimer, is resistant to degradation. Complete removal of the linker peptide appears to be a prerequisite to the complete activation of the enzyme.
- Glycosylation at posLast=162162, isoforms=3, 4178, isoforms=3, 4200, isoforms=3, 4217, isoforms=2, 3, 4238, and isoforms=2, 3459
- Modification sites at PhosphoSitePlus
Other Protein References for HPSE Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for HPSE
- Novus Biologicals Antibodies for HPSE
-
Cloud-Clone Corp. Antibodies for HPSE
- Invitrogen Antibodies for HPSE
- antibodies-online Antibodies for HPSE: See all 176
- GeneTex HPSE antibody for HPSE
-
Custom Antibody ServicesProSci Antibodies for HPSE
-
Santa Cruz Biotechnology (SCBT) Antibodies for HPSE
Protein Products
- R&D Systems Proteins and Enzymes for HPSE (Heparanase/HPSE)
-
OriGene Purified Proteins for HPSE
- Search Origene for MassSpec and Protein Over-expression Lysates for HPSE
- Origene Custom Protein Services for HPSE
- ProSpec Recombinant Proteins for HPSE
-
Cloud-Clone Corp. Proteins for HPSE
- antibodies-online Proteins for HPSE: See all 36
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HPSE
No data available for DME Specific Peptides for HPSE Gene
Domains & Families for HPSE Gene
Protein Domains for HPSE Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HPSE Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y251- Family:
-
- Belongs to the glycosyl hydrolase 79 family.
No data available for Gene Families for HPSE Gene
Function for HPSE Gene
Molecular function for HPSE Gene
- GENATLAS Biochemistry:
- heparanase,widely expressed,noteworthy in placenta,platelet,spleen,smooth muscle cells,endoglyosidase cleaving heparan sulfate proteoglycan at a limited mumber of sites along the polysaccharide chain,essential in the disassembly of the extracellular matrix (ECM) by invading cells,involved in tumor invasion and metastasis
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- pH dependence: Optimum pH is 4-6. {ECO:0000269 PubMed:10446189, ECO:0000269 PubMed:10764835, ECO:0000269 PubMed:12713442, ECO:0000269 PubMed:15848168};
- UniProtKB/Swiss-Prot CatalyticActivity:
- Endohydrolysis of (1->4)-beta-D-glycosidic bonds of heparan sulfate chains in heparan sulfate proteoglycan.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by EDTA, laminarin sulfate and, to a lower extent, by heparin and sulfamin and activated by calcium and magnesium.
- UniProtKB/Swiss-Prot Function:
- Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the extacellular matrix (ECM), independent of its enzymatic activity. Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. Regulates osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis.
Enzyme Numbers (IUBMB) for HPSE Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004566 | beta-glucuronidase activity | TAS | 10395325 |
| GO:0005515 | protein binding | IPI | 15292202 |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds | IEA | -- |
| GO:0030305 | heparanase activity | TAS | -- |
Phenotypes for HPSE Gene
- MGI mutant phenotypes for HPSE:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for HPSE:
Animal Models for HPSE Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for HPSE
-
ViGene Biosciences lentiviral particle packaged cDNA for HPSE gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HPSE gene
- Search ViGene Biosciences for HPSE
CRISPR Products
-
OriGene CRISPR knockouts for HPSE
-
Santa Cruz Biotechnology (SCBT) CRISPR for HPSE
- GenScript: Design CRISPR guide RNA sequences for HPSE
miRNA for HPSE Gene
- miRTarBase miRNAs that target HPSE
-
- hsa-mir-1258 (MIRT005537)
- hsa-mir-1261 (MIRT530348)
- hsa-mir-3161 (MIRT530349)
- hsa-mir-190a-3p (MIRT530350)
- hsa-mir-4536-5p (MIRT530351)
- hsa-mir-376c-5p (MIRT530352)
- hsa-mir-376b-5p (MIRT530353)
- hsa-mir-5011-5p (MIRT530354)
- hsa-mir-6849-5p (MIRT530355)
- hsa-mir-3681-5p (MIRT530356)
- hsa-mir-186-5p (MIRT530357)
- hsa-mir-3133 (MIRT530358)
- hsa-mir-6836-3p (MIRT673594)
- hsa-mir-5001-3p (MIRT673595)
- hsa-mir-6783-3p (MIRT673596)
- hsa-mir-1343-3p (MIRT673597)
- hsa-mir-4465 (MIRT673598)
- hsa-mir-26b-5p (MIRT673599)
- hsa-mir-26a-5p (MIRT673600)
- hsa-mir-1297 (MIRT673601)
- hsa-mir-891a-3p (MIRT673602)
- hsa-mir-23b-5p (MIRT673603)
- hsa-mir-23a-5p (MIRT673604)
- hsa-mir-4284 (MIRT673605)
- hsa-mir-6829-3p (MIRT673606)
- hsa-mir-6791-3p (MIRT673607)
- hsa-mir-6778-3p (MIRT673608)
- hsa-mir-4772-3p (MIRT673609)
- hsa-mir-4638-5p (MIRT673610)
- hsa-mir-1307-3p (MIRT673611)
- hsa-mir-1304-3p (MIRT673612)
- hsa-mir-6741-3p (MIRT673613)
- hsa-mir-6742-3p (MIRT673614)
- hsa-mir-6852-5p (MIRT673615)
- hsa-mir-939-3p (MIRT673616)
- hsa-mir-660-3p (MIRT673617)
- hsa-mir-6890-3p (MIRT673618)
- hsa-mir-5697 (MIRT673619)
- hsa-mir-4279 (MIRT680209)
- hsa-mir-5571-5p (MIRT680210)
- hsa-mir-3189-5p (MIRT685077)
- hsa-mir-4758-3p (MIRT685078)
- hsa-mir-5699-5p (MIRT685079)
- hsa-mir-324-3p (MIRT685080)
- hsa-mir-1913 (MIRT685081)
- hsa-mir-1976 (MIRT685082)
- hsa-mir-3653-5p (MIRT685083)
- hsa-mir-6747-3p (MIRT685084)
- hsa-mir-6727-3p (MIRT685085)
- hsa-mir-4722-3p (MIRT685086)
- hsa-mir-6849-3p (MIRT685087)
- hsa-mir-6736-5p (MIRT702803)
- hsa-mir-4701-3p (MIRT702804)
- hsa-mir-1262 (MIRT702805)
- hsa-mir-183-5p (MIRT702806)
- hsa-mir-6512-3p (MIRT702807)
- hsa-mir-6720-5p (MIRT702808)
- hsa-mir-542-3p (MIRT702809)
- hsa-mir-6776-5p (MIRT702810)
- hsa-mir-766-3p (MIRT702811)
- hsa-mir-508-5p (MIRT702812)
- hsa-mir-7153-3p (MIRT702813)
miRNA Products
- Search ViGene Biosciences for HPSE
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HPSE
- Browse OriGene Inhibitory RNA Products For HPSE
-
ViGene Biosciences ready-to-package AAV shRNAs for HPSE gene
Clone Products
- Sino Biological Human cDNA Clone for HPSE
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HPSE
Cell Line Products
-
Horizon Cell Lines for HPSE
-
ViGene Biosciences adenoviral particle packaged cDNA for HPSE gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HPSE gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HPSE gene
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-11893) for HPSE
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HPSE Gene
Localization for HPSE Gene
Subcellular locations from UniProtKB/Swiss-Prot for HPSE Gene
- Lysosome membrane; Peripheral membrane protein. Secreted. Nucleus. Note=Proheparanase is secreted via vesicles of the Golgi. Interacts with cell membrane heparan sulfate proteoglycans (HSPGs). Endocytosed and accumulates in endosomes. Transferred to lysosomes where it is proteolytically cleaved to produce the active enzyme. Under certain stimuli, transferred to the cell surface. Associates with lipid rafts. Colocalizes with SDC1 in endosomal/lysosomal vesicles. Accumulates in perinuclear lysosomal vesicles. Heparin retains proheparanase in the extracellular medium (By similarity). {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| lysosome | 5 |
| golgi apparatus | 2 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005578 | proteinaceous extracellular matrix | IBA | -- |
| GO:0005634 | nucleus | IDA,IEA | 20309870 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005764 | lysosome | IEA,IDA | 15126626 |
Pathways & Interactions for HPSE Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Glycosaminoglycan metabolism | ||
| 2 | Innate Immune System |
.61
|
|
| 3 | Metabolism |
.37
|
|
| 4 | Glycosaminoglycan degradation | ||
| 5 | Proteoglycans in cancer | ||
Pathways by source for HPSE Gene
1 BioSystems pathway for HPSE Gene
8 Reactome pathways for HPSE Gene
3 KEGG pathways for HPSE Gene
1 R&D Systems pathway for HPSE Gene
Interacting Proteins for HPSE Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005975 | carbohydrate metabolic process | IEA | -- |
| GO:0006027 | glycosaminoglycan catabolic process | TAS | -- |
| GO:0006029 | proteoglycan metabolic process | TAS | 10446189 |
| GO:0007155 | cell adhesion | IEA | -- |
| GO:0007160 | cell-matrix adhesion | IDA | 12773484 |
No data available for SIGNOR curated interactions for HPSE Gene
Drugs & Compounds for HPSE Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Heparin | Approved, Investigational | Pharma | Antagonist, cofactor, Enzyme, substrate | 848,265 | ||
| Dalteparin | Approved | Pharma | Enzyme, substrate | 317 | ||
| Water | Approved | Pharma | 0 | |||
| PI-88 | Investigational | Pharma | inhibitor | 0 | ||
| 2-Methoxyestradiol | Investigational | Pharma | Apoptotic and antiangiogenic agent | 9 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| OGT 2115 |
|
853929-59-6 |
|
|
(5) Tocris Compounds for HPSE Gene
| Compound | Action | Cas Number |
|---|---|---|
| 2-Methoxyestradiol | Apoptotic and antiangiogenic agent | 362-07-2 |
| CHC | MCT inhibitor; decreases glycoloysis | 28166-41-8 |
| OGT 2115 | Antiangiogenic. Heparanase inhibitor | 853929-59-6 |
| P005091 | USP7 inhibitor | 882257-11-6 |
| PX 12 | Thioredoxin-1 inhibitor | 141400-58-0 |
Transcripts for HPSE Gene
mRNA/cDNA for HPSE Gene
- (4) REFSEQ mRNAs :
- (18) Additional mRNA sequences :
- (73) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HPSE
-
Santa Cruz Biotechnology (SCBT) CRISPR for HPSE
- GenScript: Design CRISPR guide RNA sequences for HPSE
miRNA Products
- Search ViGene Biosciences for HPSE
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HPSE
- Browse OriGene Inhibitory RNA Products For HPSE
-
ViGene Biosciences ready-to-package AAV shRNAs for HPSE gene
Clone Products
- Sino Biological Human cDNA Clone for HPSE
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HPSE
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-11893) for HPSE
Expression for HPSE Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Ovary (Reproductive System)
- Cumulus Cells Antral Follicle
-
Blood (Hematopoietic System)
- Megakaryocytes Hematopoietic Bone Marrow
- Neural Tube (Nervous System)
-
Placenta (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for HPSE Gene
This gene is overexpressed in Whole Blood (x19.5).
This gene is overexpressed in Platelet (38.9), Peripheral blood mononuclear cells (19.1), and Serum (8.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HPSE Gene
NURSA nuclear receptor signaling pathways regulating expression of HPSE Gene:
HPSESOURCE GeneReport for Unigene cluster for HPSE Gene:
Hs.44227mRNA Expression by UniProt/SwissProt for HPSE Gene:
Q9Y251-HPSE_HUMAN
Tissue specificity:
Highly expressed in placenta and spleen and weakly expressed in lymph node, thymus, peripheral blood leukocytes, bone marrow, endothelial cells, fetal liver and tumor tissues. Also expressed in hair follicles, specifically in both Henles and Huxleys layers of inner the root sheath (IRS) at anagen phase.
Evidence on tissue expression from TISSUES for HPSE Gene
- Blood(4.4)
- Liver(4.4)
- Intestine(4.3)
- Kidney(4.3)
- Pancreas(4.2)
- Nervous system(2.1)
Primer Products
-
OriGene qPCR primer pairs for HPSE
-
OriGene qPCR primer pairs and template standards for HPSE
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for HPSE Gene
Orthologs for HPSE Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HPSE 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HPSE 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HPSE 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Hpse 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hpse 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HPSE 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HPSE 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HPSE 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hpse 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hpse 34 35 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | GUS3 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os06g0179000 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for HPSE was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HPSE Gene
(1) SIMAP similar genes for HPSE Gene using alignment to 4 proteins:
Variants for HPSE Gene
| SNP ID | Clin | Chr 04 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_023600 | Some hepatocellular carcinoma | ||||
| rs1000020561 | -- | 83,328,258(+) | TAGGC(A/G)CAGGA | intron-variant | |
| rs1000074379 | -- | 83,327,963(+) | GCCTA(A/G)GTCAG | intron-variant | |
| rs1000093623 | -- | 83,314,751(+) | AGAAA(G/T)ATCTC | intron-variant | |
| rs10001403 | -- | 83,298,925(+) | ACTCA(A/T)AAACT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv156n6 | CNV | deletion | 16902084 |
| esv1009126 | CNV | deletion | 20482838 |
| esv1199239 | CNV | deletion | 17803354 |
| esv2180695 | CNV | deletion | 18987734 |
| esv2448972 | CNV | deletion | 19546169 |
| esv2600138 | CNV | deletion | 19546169 |
| esv2667959 | CNV | deletion | 23128226 |
| esv2727902 | CNV | deletion | 23290073 |
| esv2727903 | CNV | deletion | 23290073 |
| esv3564161 | CNV | deletion | 23714750 |
| esv3601192 | CNV | gain | 21293372 |
| esv3601194 | CNV | gain | 21293372 |
| esv3893971 | CNV | gain | 25118596 |
| esv4639 | CNV | loss | 18987735 |
| esv6001 | CNV | loss | 19470904 |
| nsv1139276 | CNV | deletion | 24896259 |
| nsv1150337 | CNV | deletion | 26484159 |
| nsv526041 | CNV | loss | 19592680 |
| nsv829992 | CNV | loss | 17160897 |
| nsv956348 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
46.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.85;
48.14% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HPSE Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HPSE Gene
Disorders for HPSE Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| israeli tick typhus |
|
|
| urofacial syndrome 1 |
|
|
| hypoparathyroidism, sensorineural deafness, and renal dysplasia |
|
|
| keratocystic odontogenic tumor |
|
|
| hemophagocytic lymphohistiocytosis, familial, 2 |
|
|
Search HPSE in MalaCards
View complete list of genes associated with diseases
Relevant External Links for HPSE
No data available for UniProtKB/Swiss-Prot and Genatlas for HPSE Gene
Publications for HPSE Gene
- Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis. (PMID: 10395325) Vlodavsky I. … Pecker I. (Nat. Med. 1999) 2 3 4 22 64
- Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis. (PMID: 20097882) Purushothaman A. … Sanderson R.D. (Blood 2010) 3 4 22 64
- Inverse correlation between HPSE gene single nucleotide polymorphisms and heparanase expression: possibility of multiple levels of heparanase regulation. (PMID: 19406828) Ostrovsky O. … Nagler A. (J. Leukoc. Biol. 2009) 3 22 46 64
- Heparanase 1: a key participant of inner root sheath differentiation program and hair follicle homeostasis. (PMID: 18557927) Malgouries S. … Bernard B.A. (Exp. Dermatol. 2008) 3 4 22 64
- Characterization of HPSE gene single nucleotide polymorphisms in Jewish populations of Israel. (PMID: 17095861) Ostrovsky O. … Nagler A. (Acta Haematol. 2007) 3 22 46 64
Products for HPSE Gene
- Browse R&D Systems for Antibodies
- R&D Systems Proteins and Enzymes for HPSE (Heparanase/HPSE)
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for HPSE
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HPSE
- Search Origene for MassSpec and Protein Over-expression Lysates for HPSE
- Origene Custom Protein Services for HPSE
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HPSE
- Browse OriGene Inhibitory RNA Products For HPSE
- OriGene qPCR primer pairs and template standards for HPSE
- OriGene qPCR primer pairs for HPSE
- OriGene CRISPR knockouts for HPSE
- OriGene ORF clones in human for HPSE
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HPSE
- GenScript: Next-day shipping cDNA ORF clone for HPSE in any vector
- GenScript Custom Purified and Recombinant Proteins Services for HPSE
- GenScript Custom Assay Services for HPSE
- GenScript Custom overexpressing Cell Line Services for HPSE
- GenScript: Design CRISPR guide RNA sequences for HPSE
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for HPSE
- Sino Biological Human cDNA Clone for HPSE
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for HPSE
- Novus Biologicals proteins and lysates for HPSE
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ProSpec Recombinant Proteins for HPSE
- Cloud-Clone Corp. Antibodies for HPSE
- Cloud-Clone Corp. Proteins for HPSE
- Cloud-Clone Corp Assay Kits for HPSE
- Taconic Biosciences Mouse Models for HPSE
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Addgene plasmids for HPSE
- antibodies-online Antibodies for HPSE: See all 176
- antibodies-online Kits for HPSE: See all 45
- antibodies-online Proteins for HPSE: See all 36
- Search antibodies-online for peptides
- GeneTex HPSE antibody for HPSE
- Search GeneTex for Proteins for HPSE
- ViGene Biosciences adenoviral particle packaged cDNA for HPSE gene
- ViGene Biosciences lentiviral particle packaged cDNA for HPSE gene
- ViGene Biosciences ready-to-package AAV shRNAs for HPSE gene
- Search ViGene Biosciences for HPSE
- Santa Cruz Biotechnology (SCBT) Antibodies for HPSE
- Search Santa Cruz Biotechnology (SCBT) for HPSE siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HPSE
- Custom Antibody ServicesProSci Antibodies for HPSE
- Search for HPSE Proteins at ProSci
- Horizon Cell Lines for HPSE
- Cyagen custom Knockout/knockin (KOKI) mouse models for HPSE
- VectorBuilder custom plasmid, inducible vectors for HPSE
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HPSE
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HPSE Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer