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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HPRT1 Gene

protein-coding   GIFtS: 71
GCID: GC0XP133594

Hypoxanthine Phosphoribosyltransferase 1


(Previous symbol: HPRT)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Hypoxanthine Phosphoribosyltransferase 11 2     EC 2.4.2.83 8
HPRT1 2 3 5     Lesch-Nyhan Syndrome1
HGPRT2 3     Hypoxanthine-Guanine Phosphoribosyltransferase2
HGPRTase2 3     

External Ids:    HGNC: 51571   Entrez Gene: 32512   Ensembl: ENSG000001657047   OMIM: 3080005   UniProtKB: P004923   

Export aliases for HPRT1 gene to outside databases

Previous GC identifers: GC0XP128239 GC0XP130440 GC0XP131539 GC0XP132299 GC0XP133319 GC0XP133421 GC0XP122992


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HPRT1 Gene:
The protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine
monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from
5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides
through the purine salvage pathway. Mutations in this gene result in Lesch-Nyhan syndrome or gout.(provided by
RefSeq, Jun 2009)

GeneCards Summary for HPRT1 Gene: 
HPRT1 (hypoxanthine phosphoribosyltransferase 1) is a protein-coding gene. Diseases associated with HPRT1 include lesch-nyhan syndrome, and gout, and among its related super-pathways are Metabolic pathways and Purine metabolism. GO annotations related to this gene include magnesium ion binding and protein homodimerization activity. An important paralog of this gene is PRTFDC1.

UniProtKB/Swiss-Prot: HPRT_HUMAN, P00492
Function: Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the
5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation
of purine nucleotides through the purine salvage pathway

Gene Wiki entry for HPRT1 (Hypoxanthine-guanine phosphoribosyltransferase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_011786.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HPRT1 gene promoter:
         p53   Nkx2-2   POU6F1 (c2)   AP-2gamma   NF-kappaB   FOXL1   POU2F1   NF-kappaB2   POU2F1a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHPRT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for HPRT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HPRT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26.1   Ensembl cytogenetic band:  Xq26.2   HGNC cytogenetic band: Xq26.2

HPRT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HPRT1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP133594:  view genomic region     (about GC identifiers)

Start:
133,594,175 bp from pter      End:
133,654,543 bp from pter
Size:
60,369 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HPRT_HUMAN, P00492 (See protein sequence)
Recommended Name: Hypoxanthine-guanine phosphoribosyltransferase  
Size: 218 amino acids; 24579 Da
Cofactor: Binds 2 magnesium ions per subunit. The magnesium ions are essentially bound to the substrate and have
few direct interactions with the protein
Subunit: Homotetramer
Subcellular location: Cytoplasm
6/9 PDB 3D structures from and Proteopedia for HPRT1 (see all 9):
1BZY (3D)        1D6N (3D)        1HMP (3D)        1Z7G (3D)        2VFA (3D)        3GEP (3D)    
Secondary accessions: A6NHF0 B2R8M9

Explore the universe of human proteins at neXtProt for HPRT1: NX_P00492

Explore proteomics data for HPRT1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P00492

  • 4/11 DME Specific Peptides for HPRT1 (P00492) (see all 11)
     VLIVEDI  LIVEDIID  CVISETGK  VEDIIDTG 

    HPRT1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HPRT1 Protein Expression
    REFSEQ proteins: NP_000185.1  
    ENSEMBL proteins: 
     ENSP00000298556  
    Reactome Protein details: P00492
    Human Recombinant Protein Products for HPRT1: 
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    Novus Biologicals HPRT1 Proteins
    Novus Biologicals HPRT1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for HPRT1
    Cloud-Clone Corp. Proteins for HPRT1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    HPRT1 for ontologies           About GeneDecksing



    HPRT1 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR005904 Hxn_phspho_trans
     IPR000836 PRibTrfase_dom

    Graphical View of Domain Structure for InterPro Entry P00492

    ProtoNet protein and cluster: P00492

    1 Blocks protein domain: IPB002375 Purine/pyrimidine phosphoribosyl transferase

    UniProtKB/Swiss-Prot: HPRT_HUMAN, P00492
    Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family


    HPRT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HPRT_HUMAN, P00492
    Function: Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the
    5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation
    of purine nucleotides through the purine salvage pathway
    Catalytic activity: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
    Catalytic activity: GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate
    Biophysicochemical properties: Kinetic parameters: KM=5.4 uM for IMP; KM=0.45 uM for hypoxanthine; KM=25 uM for
    pyrophosphate; KM=31 uM for phosphoribosylpyrophosphate;

         Genatlas biochemistry entry for HPRT1:
    hypoxanthine phosphoribosyltransferase,purine salvage pathway

         Enzyme Number (IUBMB): EC 2.4.2.81 2

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0000287magnesium ion binding IDA10360366
    GO:0004422hypoxanthine phosphoribosyltransferase activity IDA19527031
    GO:0005515protein binding IPI16189514
    GO:0042802identical protein binding ----
         
    HPRT1 for ontologies           About GeneDecksing


    Phenotypes:
         15/25 MGI mutant phenotypes (inferred from 122 alleles(MGI details for Hprt) (see all 25):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 

    HPRT1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Hprttm1.1Pobe for HPRT1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for HPRT1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HPRT1 
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    SwitchGear 3'UTR luciferase reporter plasmidHPRT1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HPRT1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HPRT1 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    2Purine metabolism
    Purine metabolism0.38
    ATP/ITP metabolism0.31
    3Purine metabolism
    Purine metabolism0.42
    Purine salvage0.39
    Metabolism of nucleotides0.42
    4adenine and adenosine salvage III
    adenine and adenosine salvage III0.75
    guanine and guanosine salvage I0.50
    5Antimetabolite Pathway - Folate Cycle, Pharmacodynamics
    Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for HPRT1
        ATP/ITP metabolism


    1 GeneGo (Thomson Reuters) Pathway for HPRT1
        ATP/ITP metabolism

    3 BioSystems Pathways for HPRT1
        Nucleotide Metabolism
    adenine and adenosine salvage III
    guanine and guanosine salvage I


    4        Reactome Pathways for HPRT1
        Metabolism of nucleotides
    Metabolism
    Purine salvage
    Purine metabolism

    1 PharmGKB Pathway for HPRT1
        Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics

    3         Kegg Pathways  (Kegg details for HPRT1):
        Purine metabolism
    Drug metabolism - other enzymes
    Metabolic pathways

    UniProtKB/Swiss-Prot: HPRT_HUMAN, P00492
    Pathway: Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1


    HPRT1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HPRT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/97 Interacting proteins for HPRT1 (P004921, 2, 3 ENSP000002985564) via UniProtKB, MINT, STRING, and/or I2D (see all 97)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    WDYHV1Q96HA81, 2, 3, ENSP000002873874EBI-748210,EBI-741158 MINT-67224 I2D: score=5 STRING: ENSP00000287387
    PRTFDC1Q9NRG12, 3, ENSP000003186024MINT-68331 I2D: score=5 STRING: ENSP00000318602
    HUS1O609213, ENSP000002587744I2D: score=2 STRING: ENSP00000258774
    FANCAO153603, ENSP000003739524I2D: score=1 STRING: ENSP00000373952
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/28 biological process terms (GO ID links to tree view) (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001975response to amphetamine IEA--
    GO:0006144purine nucleobase metabolic process TAS--
    GO:0006164purine nucleotide biosynthetic process IMP9824441
    GO:0006166purine ribonucleoside salvage IMP9824441
    GO:0006168adenine salvage IBA--

    HPRT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HPRT1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HPRT1 (HPRT)

    10/12 HMDB Compounds for HPRT1 (see all 12)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenine1,6-Dihydro-6-iminopurine (see all 19)73-24-5--
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    GuanineGUN (see all 26)73-40-5--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Hypoxanthine1,7-Dihydro-6H-purin-6-one (see all 20)68-94-0--
    Inosinic acid5'-IMP (see all 9)131-99-7--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Phosphoribosyl pyrophosphate5-Phospho-a-D-ribose-1-diphosphate (see all 37)7540-64-9--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    8 DrugBank Compounds for HPRT1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Thioguanine2-Amino 6MP (see all 14)154-42-7enzymesubstrate14529546 11545274 15136753 11756148 1383700
    3h-Pyrazolo[4,3-D]Pyrimidin-7-Ol-- --target--17139284 17016423 10592235
    5--Monophosphate-9-Beta-D-Ribofuranosyl Xanthine-- --target--17139284 17016423 10592235
    9-Deazaguanine-- --target--17139284 17016423 10592235
    Alpha-Phosphoribosylpyrophosphoric Acid-- 13270-65-0target--17139284 17016423 10592235
    Pyrophosphate 2--- --target--17139284 17016423 10592235
    AzathioprineAzathioprin (see all 3)446-86-6targetinhibitor18020555 15354273
    Mercaptopurine6 MP (see all 5)50-44-2targetinhibitor15354273

    10/126 Novoseek inferred chemical compound relationships for HPRT1 gene (see all 126)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypoxanthine 93.4 273 17129743 (3), 2397107 (2), 8824508 (2), 10657589 (2) (see all 99)
    6 thioguanine 91.5 152 9262380 (5), 7681532 (4), 9855005 (3), 17066413 (3) (see all 84)
    purine 83.3 130 1311306 (3), 12429535 (2), 10850548 (2), 9824441 (2) (see all 88)
    prpp 80.6 48 1311306 (4), 10657589 (3), 18536021 (2), 15819884 (2) (see all 19)
    actb 78.1 24 16777070 (3), 15720708 (3), 18191039 (2), 17257226 (2) (see all 15)
    guanine 74.6 71 1850982 (2), 8589681 (2), 8962428 (2), 10576552 (2) (see all 52)
    1,3-butadiene 74.5 57 11397407 (5), 11397400 (4), 15036120 (4), 18288319 (3) (see all 22)
    1-nitrosopyrene 73 5 9202750 (1), 8033153 (1), 7592980 (1), 8668188 (1)
    butadiene monoxide 72.5 9 8070866 (2), 8149485 (2), 9379915 (1), 9463556 (1) (see all 5)
    bpde 71.8 41 1381465 (4), 2120584 (3), 2122466 (3), 9202750 (2) (see all 16)

    1 PharmGKB related drug/compound annotation for HPRT1 gene    About this table
    Drug/compound PharmGKB Annotation
    mycophenolic acid

    Search CenterWatch for drugs/clinical trials and news about HPRT1 / HPRT

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HPRT1 gene: 
    NM_000194.2  

    Unigene Cluster for HPRT1:

    Hypoxanthine phosphoribosyltransferase 1
    Hs.412707  [show with all ESTs]
    Unigene Representative Sequence: NM_000194
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000298556(uc004exl.4) ENST00000462974 ENST00000475720
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK313435.1 BC000578.2 BT019350.1 CR407645.1 L29382.1 L29383.1 M24772.1 M31642.1 
    U31737.1 

    7 DOTS entries:

    DT.315146  DT.101982197  DT.95182310  DT.121305200  DT.92441189  DT.100800735  DT.99955125 

    24/275 AceView cDNA sequences (see all 275):

    AV713164 BE548220 AV648680 CA419764 BQ774854 BQ772821 BM665410 CA418043 
    BM968309 AI990397 H06322 CB158613 BF725707 AI246714 BX281515 AW949523 
    N47311 BM712509 AA320916 BE218846 CR614617 BM315030 CD106070 AA122343 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HPRT1 expression in normal human tissues (normalized intensities)      HPRT1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATCTTCTAA
    HPRT1 Expression
    About this image


    HPRT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/27 selected tissues (see all 27) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Thalamus
             brain/midbrain   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             heart/ventricle   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             visceral organ   

    See HPRT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HPRT1

    SOURCE GeneReport for Unigene cluster: Hs.412707
        SABiosciences Expression via Pathway-Focused PCR Arrays including HPRT1 (see all 149): 
              Antiviral Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Wound Healing in human mouse rat
              Prostate Cancer in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HPRT1
    OriGene qSTAR qPCR primer pairs in human, mouse for HPRT1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HPRT1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HPRT1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HPRT1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HPRT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HPRT1 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hprt1 , 5 hypoxanthine guanine phosphoribosyl transferase1, 5 93.43(n)1
    96.79(a)1
      X (29.31 cM)5
    154521  NM_013556.21  NP_038584.21 
     529881375 
    chicken
    (Gallus gallus)
    Aves HPRT11 hypoxanthine phosphoribosyltransferase 1 81.04(n)
    90.83(a)
      395653  NM_204848.1  NP_990179.1 
    lizard
    (Anolis carolinensis)
    Reptilia HPRT16
    Uncharacterized protein
    84(a)
    1 ↔ 1
    GL343761.1(177239-198233)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia MGC762232 hypothetical protein MGC76223 79.79(n)    BC064242.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.16682 Danio rerio cDNA clone MGC56221 IMAGE5600947, complete more 78.57(n)    BC046003.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y105E8B.53
    CELE_Y105E8B.51
    Protein Y105E8B.51 48(a)3
    51.89(n)1
    49.06(a)1
      I(14665437-14669289)3
    1733231  NM_061144.41  NP_493545.11 


    ENSEMBL Gene Tree for HPRT1 (if available)
    TreeFam Gene Tree for HPRT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HPRT1 gene
    PRTFDC12  
    1 SIMAP similar gene for HPRT1 using alignment to 2 protein entries:     HPRT_HUMAN (see all proteins):
    PRTFDC1

    HPRT1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for HPRT1
    PGOHUM00000242429 PGOHUM00000245472 PGOHUM00000235542


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/725 SNPs in HPRT1 are shown (see all 725)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0067554
    Gout HPRT-related (GOUT-HPRT)4--see VAR_0067552 C W mis40--------
    VAR_0067654
    Lesch-Nyhan syndrome (LNS)4--see VAR_0067652 R P mis40--------
    VAR_0067744
    Lesch-Nyhan syndrome (LNS)4--see VAR_0067742 G R mis40--------
    VAR_0067974
    Gout HPRT-related (GOUT-HPRT)4--see VAR_0067972 D E mis40--------
    VAR_0067794
    Gout HPRT-related (GOUT-HPRT)4--see VAR_0067792 S L mis40--------
    VAR_0067634
    Lesch-Nyhan syndrome (LNS)4--see VAR_0067632 A P mis40--------
    VAR_0067684
    Gout HPRT-related (GOUT-HPRT)4--see VAR_0067682 V M mis40--------
    VAR_0067874
    Gout HPRT-related (GOUT-HPRT)4--see VAR_0067872 A S mis40--------
    VAR_0067904
    Lesch-Nyhan syndrome (LNS)4--see VAR_0067902 P L mis40--------
    VAR_0067784
    Gout HPRT-related (GOUT-HPRT)4--see VAR_0067782 S R mis40--------

    HapMap Linkage Disequilibrium report for HPRT1 (133594175 - 133654543 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HPRT1: --

    Human Gene Mutation Database (HGMD): HPRT1

    Locus Specific Mutation Databases (LSDB): HPRT1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HPRT1
    DNA2.0 Custom Variant and Variant Library Synthesis for HPRT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 308000   
    OMIM disorders: 300322  300323  
    UniProtKB/Swiss-Prot: HPRT_HUMAN, P00492
  • Lesch-Nyhan syndrome (LNS) [MIM:300322]: Characterized by complete lack of enzymatic activity that
    results in hyperuricemia, choreoathetosis, mental retardation, and compulsive self-mutilation. Note=The disease
    is caused by mutations affecting the gene represented in this entry
  • Gout HPRT-related (GOUT-HPRT) [MIM:300323]: Characterized by partial enzyme activity and hyperuricemia.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 20/97 diseases for HPRT1 (see all 97):    About MalaCards
    lesch-nyhan syndrome    gout    atlantoaxial subluxation    hereditary hyperuricemia
    hprt-related gout    gout, hprt1-related    adenine phosphoribosyltransferase deficiency    acute urate nephropathy
    hyperuricemia    phosphoribosylpyrophosphate synthetase superactivity    nephrolithiasis    macular holes
    purine nucleoside phosphorylase deficiency    bloom syndrome    tetrahydrobiopterin deficiency    retinal detachment
    n syndrome    down syndrome critical region    paroxysmal nocturnal hemoglobinuria    developmental disabilities

    7 diseases from the University of Copenhagen DISEASES database for HPRT1:
    Lesch-Nyhan syndrome     Hyperuricemia     Gout     N syndrome
    Purine nucleoside phosphorylase deficiency     Intellectual disability     Cancer

    HPRT1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/92 Novoseek inferred disease relationships for HPRT1 gene (see all 92)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lesch-nyhan syndrome 97.1 433 11307586 (10), 17309125 (7), 15935074 (6), 9629791 (5) (see all 99)
    hprt deficiency, partial 95.1 75 16649740 (3), 17065067 (3), 8028417 (2), 11773585 (2) (see all 37)
    hyperuricemia 78.4 46 2018042 (2), 16216473 (2), 12508781 (2), 7987318 (1) (see all 29)
    somatic mutations 73.3 47 8824508 (2), 11673087 (2), 9435878 (2), 7521002 (2) (see all 31)
    choreoathetosis 72.6 6 15193365 (1), 11307586 (1), 12927681 (1), 1487231 (1) (see all 6)
    purine metabolism disorder 71.5 4 2018042 (1), 1912725 (1), 17065067 (1)
    gout 68.3 49 8112742 (3), 1306134 (2), 10451080 (2), 15862284 (2) (see all 29)
    arthritis gouty 65.1 8 19565499 (2), 15158715 (1), 15193365 (1), 15862284 (1) (see all 6)
    chromosomal aberrations 63.1 49 1879404 (3), 8143603 (2), 1719390 (2), 7523909 (2) (see all 39)
    xeroderma pigmentosum 60.6 7 9379920 (2), 1992158 (1), 7683756 (1), 1372100 (1) (see all 5)

    Genatlas disease: HPRT1
    Lesch Nyhan syndrome,including severe juvenile gout

    GeneTests: HPRT1
    GeneReviews: HPRT1
    Genetic Association Database (GAD): HPRT1
    Human Genome Epidemiology (HuGE) Navigator: HPRT1 (13 documents)

    Export disorders for HPRT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HPRT1 gene, integrated from 9 sources (see all 1004) (see top 10):
    (articles sorted by number of sources associating them with HPRT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A review of the molecular basis of hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency. (PubMed id 1487231)1, 2, 9 Sculley D.G.... Gordon R.B. (1992)
    2. Characterization of mutations in phenotypic variants of hypoxanthine phosphoribosyltransferase deficiency. (PubMed id 1301916)1, 2, 9 Sege-Paterson K.... Nyhan W.L. (1992)
    3. Hypoxanthine-guanine phosphoribosyltransferase deficiency: analysis of HPRT mutations by direct sequencing and allele-specific amplification. (PubMed id 1937471)1, 2, 9 Sculley D.G.... Gordon R.B. (1991)
    4. Identification of 17 independent mutations responsible for human hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency. (PubMed id 2018042)1, 2, 9 Davidson B.L.... Palella T.D. (1991)
    5. Sequential evaluation of thiopurine methyltransferase, inosine triphosphate pyrophosphatase, and HPRT1 genes polymorphisms to explain thiopurines' toxicity and efficacy. (PubMed id 17697207)1, 4, 9 Palmieri O....Annese V. (2007)
    6. Differential interactions between GSTM1 and NAT2 genotypes on aromatic DNA adduct level and HPRT mutant frequency in lung cancer patients and population controls. (PubMed id 11219770)1, 4, 9 Hou S.M....Lambert B. (2001)
    7. Ternary complex structure of human HGPRTase, PRPP, Mg2+, and the inhibitor HPP reveals the involvement of the flexible loop in substrate binding. (PubMed id 10338013)1, 2, 9 Balendiran G.K.... Craig S.P. III (1999)
    8. An asymptomatic germline missense base substitution in the hypoxanthine phosphoribosyltransferase (HPRT) gene that reduces the amount of enzyme in humans. (PubMed id 9003484)1, 2, 9 Fujimori S....Kamatani N. (1997)
    9. The crystal structure of human hypoxanthine-guanine phosphoribosyltransferase with bound GMP. (PubMed id 8044844)1, 2, 9 Eads J.C.... Sacchettini J.C. (1994)
    10. Genetic variations in the HGPRT, ITPA, IMPDH1, IMPDH2 , and GMPS genes in Japanese individuals. (PubMed id 20045992)1, 4, 9 Kudo M....Hiratsuka M. (2009)
    11. Mutagenicity and potential carcinogenicity of thiopur ine treatment in patients with inflammatory bowel disease. (PubMed id 19706768)1, 4, 9 Nguyen T....Finette B.A. (2009)
    12. The crystal structure of free human hypoxanthine-guanine phosphoribosyltransferase reveals extensive conformational plasticity throughout the catalytic cycle. (PubMed id 15990111)1, 2, 9 Keough D.T....Guddat L.W. (2005)
    13. Differences in HPRT mutant frequency among middle-aged Flemish women in association with area of residence and blood lead levels. (PubMed id 15204312)1, 4, 9 Van Larebeke N....Kleinjans J. (2004)
    14. Mutational spectral analysis at the HPRT locus in healthy children. (PubMed id 12175903)1, 3, 9 Finette B.A....Vacek P.M. (2002)
    15. A recurrent large Alu-mediated deletion in the hypoxanthine phosphoribosyltransferase (HPRT1) gene associated with Lesch-Nyhan syndrome. (PubMed id 11668636)1, 4, 9 Mizunuma M....Kamatani N. (2001)
    16. The point mutation of hypoxanthine-guanine phosphoribosyltransferase (HPRTEdinburgh) and detection by allele-specific polymerase chain reaction. (PubMed id 1551676)1, 2, 9 Lightfoot T.... Snyder F.F. (1992)
    17. Determination of the mutations responsible for the Lesch-Nyhan syndrome in 17 subjects. (PubMed id 2071157)1, 2, 9 Tarle S.A.... Palella T.D. (1991)
    18. Identification of a single nucleotide substitution in the coding sequence of in vitro amplified cDNA from a patient with partial HPRT deficiency (HPRTBRISBANE). (PubMed id 2246854)1, 2, 9 Gordon R.B.... Emmerson B.T. (1990)
    19. Multiplex DNA deletion detection and exon sequencing of the hypoxanthine phosphoribosyltransferase gene in Lesch-Nyhan families. (PubMed id 2347587)1, 2, 9 Gibbs R.A.... Caskey C.T. (1990)
    20. Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics. (PubMed id 19527031)1, 2 Keough D.T.... Guddat L.W. (2009)
    21. Fine mapping of the MHC Class III region demonstrates association of AIF1 and rheumatoid arthritis. (PubMed id 18835879)1, 4 Harney S.M....Brown M.A. (2008)
    22. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    23. Studies on the HPRT mutant frequency in T lymphocytes from healthy Indian male population as a function of age and smoking. (PubMed id 15491638)1, 4 Kumar P.R....Jeevanram R.K. (2004)
    24. In utero DNA damage from environmental pollution is associated with somatic gene mutation in newborns. (PubMed id 12376523)1, 4 Perera F....O'Neill J.P. (2002)
    25. The 2.0 A structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor. (PubMed id 10360366)1, 2 Shi W.... Almo S.C. (1999)
    26. Identification of a new missense mutation in exon 2 of the human hypoxanthine phosphoribosyltransferase gene (HPRTIsar): a further example of clinical heterogeneity in HPRT deficiencies. (PubMed id 7627191)1, 2 Burgemeister R.... Schiel W. (1995)
    27. Identification of two independent Japanese mutant HPRT genes using the PCR technique. (PubMed id 1840476)1, 2 Yamada Y.... Ogasawara N. (1991)
    28. Molecular analyses of a Lesch-Nyhan syndrome mutation (hprtMontreal) by use of T-lymphocyte cultures. (PubMed id 2358296)1, 2 Skopek T.R.... Albertini R.J. (1990)
    29. Automated DNA sequencing of the human HPRT locus. (PubMed id 2341149)1, 2 Edwards A.... Ansorge W. (1990)
    30. Identification of a single nucleotide change in the hypoxanthine- guanine phosphoribosyltransferase gene (HPRTYale) responsible for Lesch-Nyhan syndrome. (PubMed id 2910902)1, 2 Fujimori S.... Palella T.D. (1989)
    31. Molecular basis of hypoxanthine-guanine phosphoribosyltransferase deficiency in ten subjects determined by direct sequencing of amplified transcripts. (PubMed id 2738157)1, 2 Davidson B.L.... Kelley W.N. (1989)
    32. Human hypoxanthine-guanine phosphoribosyltransferase deficiency. The molecular defect in a patient with gout (HPRTAshville). (PubMed id 2909537)1, 2 Davidson B.L.... Palella T.D. (1989)
    33. Identification of mutations leading to the Lesch-Nyhan syndrome by automated direct DNA sequencing of in vitro amplified cDNA. (PubMed id 2928313)1, 2 Gibbs R.A.... Caskey C.T. (1989)
    34. Resolution of a missense mutant in human genomic DNA by denaturing gradient gel electrophoresis and direct sequencing using in vitro DNA amplification: HPRT Munich. (PubMed id 3358423)1, 2 Cariello N.F.... Keohavong P. (1988)
    35. Biochemical basis of hypoxanthine-guanine phosphoribosyltransferase deficiency in nine families. (PubMed id 3148064)1, 2 Keough D.T.... Emmerson B.T. (1988)
    36. Hypoxanthine-guanine phosphoribosyltransferase. Genetic evidence for identical mutations in two partially deficient subjects. (PubMed id 3198771)1, 2 Davidson B.L.... Palella T.D. (1988)
    37. Identification of a single nucleotide change in a mutant gene for hypoxanthine-guanine phosphoribosyltransferase (HPRT Ann Arbor). (PubMed id 2896620)1, 2 Fujimori S.... Kelley W.N. (1988)
    38. Genetic basis of hypoxanthine guanine phosphoribosyltransferase deficiency in a patient with the Lesch-Nyhan syndrome (HPRTFlint). (PubMed id 3384338)1, 2 Davidson B.L.... Palella T.D. (1988)
    39. Human hypoxanthine-guanine phosphoribosyltransferase: a single nucleotide substitution in cDNA clones isolated from a patient with Lesch-Nyhan syndrome (HPRTMidland). (PubMed id 3265398)1, 2 Davidson B.L.... Kelly W.N. (1988)
    40. Fine structure of the human hypoxanthine phosphoribosyltransferase gene. (PubMed id 3023844)1, 2 Patel P.I.... Chinault A.C. (1986)
    41. Human hypoxanthine-guanine phosphoribosyltransferase. Structural alteration in a dysfunctional enzyme variant (HPRTMunich) isolated from a patient with gout. (PubMed id 6706936)1, 2 Wilson J.M. and Kelley W.N. (1984)
    42. Human hypoxanthine (guanine) phosphoribosyltransferase: an amino acid substitution in a mutant form of the enzyme isolated from a patient with gout. (PubMed id 6572373)1, 2 Wilson J.M.... Kelley W.N. (1983)
    43. Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase. (PubMed id 6300847)1, 2 Jolly D.J.... Friedmann T. (1983)
    44. Molecular basis of hypoxanthine-guanine phosphoribosyltransferase deficiency in a patient with the Lesch-Nyhan syndrome. (PubMed id 6853716)1, 2 Wilson J.M. and Kelley W.N. (1983)
    45. Human hypoxanthine-guanine phosphoribosyltransferase. (PubMed id 6853490)1, 2 Wilson J.M.... Kelley W.N. (1983)
    46. Human hypoxanthine-guanine phosphoribosyltransferase. Complete amino acid sequence of the erythrocyte enzyme. (PubMed id 7107641)1, 2 Wilson J.M.... Kelley W.N. (1982)
    47. Normal HPRT coding region in complete and partial HPRT deficiency. (PubMed id 18316217)1, 9 Garcia M.G....Puig J.G. (2008)
    48. Molecular analysis of hypoxanthine guanine phosphoribosyltransferase (HPRT) deficiencies: novel mutations and the spectrum of Japanese mutations. (PubMed id 18600506)1, 9 Yamada Y....Fujimori S. (2008)
    49. Radiation-induced HPRT mutations resulting from misrejoined DNA double-strand breaks. (PubMed id 18494542)1, 9 Rothkamm K....Lobrich M. (2008)
    50. Development of a bacterial screen for novel hypoxanthine-guanine phosphoribosyltransferase substrates. (PubMed id 11545274)7, 9 Shivashankar K....Balaram H. (2001)
    51. Hypoxanthine-guanine phosphoribosyl transferase regul ates early developmental programming of dopamine neurons: implications for Lesc h-Nyhan disease pathogenesis. (PubMed id 19342420)1, 9 Ceballos-Picot I....Jinnah H.A. (2009)
    52. [Deficiencies of hypoxanthine guanine phosphoribosyltransferase (HPRT)] (PubMed id 18409516)1, 9 Yamada Y. (2008)
    53. Molecular analysis of HPRT deficiencies: an update of the spectrum of Asian mutations with novel mutations. (PubMed id 17027311)1, 9 Yamada Y....Wakamatsu N. (2007)
    54. HPRTSardinia: a new point mutation causing HPRT deficiency without Lesch-Nyhan disease. (PubMed id 16216473)1, 9 Cossu A....Micheli V. (2006)
    55. Normal HPRT coding region in a male with gout due to HPRT deficiency. (PubMed id 15862284)1, 9 Dawson P.A....Emmerson B.T. (2005)
    56. Same origins of DNA replication function on the active and inactive human X chromosomes. (PubMed id 12616531)1, 9 Cohen S.M....Kaufman D.G. (2003)
    57. A transition-state analogue reduces protein dynamics in hypoxanthine-guanine phosphoribosyltransferase. (PubMed id 11434773)1, 9 Wang F....Grubmeyer C. (2001)
    58. Purine metabolism in female heterozygotes for hypoxanthine-guanine phosphoribosyltransferase deficiency. (PubMed id 9824441)1, 9 Puig J.G....Buno A.S. (1998)
    59. Acrylamide-induced molecular mutation spectra at HPRT locus in human promyelocytic leukaemia HL-60 and NB4 cell lines. (PubMed id 18407966)1, 9 Ao L....Cao J. (2008)
    60. HPRT mutations in lymphocytes from 1,3-butadiene-exposed workers in China. (PubMed id 18288319)1, 9 Liu S....Cao J. (2008)
    61. Modeling for Lesch-Nyhan disease by gene targeting in human embryonic stem cells. (PubMed id 15277709)1, 9 Urbach A....Benvenisty N. (2004)
    62. Frequent detection of T cells with mutations of the hypoxanthine-guanine phosphoribosyl transferase gene in patients with paroxysmal nocturnal hemoglobinuria. (PubMed id 11756148)7, 9 Horikawa K....Nakakuma H. (2002)
    63. High frequency of deletions at the hypoxanthine-guanine phosphoribosyltransferase locus in an ataxia-telangiectasia lymphoblastoid cell line irradiated with gamma-rays. (PubMed id 11714443)1, 9 Tachibana A....Sasaki M.S. (2001)
    64. Deficiency of the housekeeping gene hypoxanthine-guan ine phosphoribosyltransferase (HPRT) dysregulates neurogenesis. (PubMed id 19672249)1, 9 Guibinga G.H....Friedmann T. (2010)
    65. Variable expression of HPRT deficiency in 5 members of a family with the same mutation. (PubMed id 18779430)1, 9 Hladnik U....Bertelli M. (2008)
    66. The role for glutamic acid at position 196 in human hypoxanthine phosphoribosyltransferase (HPRT) as investigated using site-directed mutagenesis. (PubMed id 18600559)1, 9 Canyuk B....Tanthana C. (2008)
    67. Novel HGPRT 293 A>G point mutation presenting as neonatal acute renal failure. (PubMed id 17934765)1, 9 Wong H....Filler G. (2008)
    68. Hypoxanthine-guanine phosphoribosyltransferase deficiency: biochemical and molecular findings in six Argentine patients. (PubMed id 17454734)1, 9 Larovere L.E....de Kremer R.D. (2007)
    69. Analysis of genetic alterations and clonal proliferation in children treated for acute lymphocytic leukemia. (PubMed id 16951156)1, 9 Kendall H.E....Finette B.A. (2006)
    70. Partial hypoxanthine-guanine phosphoribosyltransferase deficiency presenting as acute renal failure. (PubMed id 16240158)1, 9 Cherian S. and Crompton C.H. (2005)
    71. Self-mutilation behaviour in Lesch-Nyhan syndrome. (PubMed id 16138897)1, 9 Cauwels R.G. and Martens L.C. (2005)
    72. Lesch-Nyhan disease in a female with a clinically normal monozygotic twin. (PubMed id 15862283)1, 9 De Gregorio L....O'Neill J.P. (2005)
    73. Mutations in the hypoxanthine guanine phosphoribosyltransferase gene (HPRT1) in Asian HPRT deficient families. (PubMed id 15571223)1, 9 Yamada Y....Ogasawara N. (2004)
    74. Structural and functional analysis of mutations at the human hypoxanthine phosphoribosyl transferase (HPRT1) locus. (PubMed id 15146465)1, 9 Duan J....Lambert B. (2004)
    75. A non-active site mutation in human hypoxanthine guanine phosphoribosyltransferase expands substrate specificity. (PubMed id 15178494)1, 9 Raman J....Balaram H. (2004)
    76. Effect of exogenous MSH6 and POLD1 expression on the mutation rate of the HPRT locus in a human colon cancer cell line with mutator phenotype, DLD-1. (PubMed id 14767555)1, 9 Yabuta T....Yokota J. (2004)
    77. The spectrum of mutations causing HPRT deficiency: an update. (PubMed id 15571220)1, 9 Jinnah H.A....O'Neill J.P. (2004)
    78. Clinical and biochemical manifestations and molecular characterization of the mutation HPRT Jerusalem. (PubMed id 15571222)1, 9 Zoref-Shani E....Sperling O. (2004)
    79. Comparative analysis of HPRT mutant frequency in children with cancer. (PubMed id 12874812)1, 9 Rice S.C....Finette B.A. (2003)
    80. Thioguanine, mercaptopurine: their analogs and nucleosides as antimetabolites. (PubMed id 14529546)7, 9 Elgemeie G.H. (2003)
    81. Childhood hyperuricemia and acute renal failure resulting from a missense mutation in the HPRT gene. (PubMed id 11891689)1, 9 Srivastava T....Simckes A.M. (2002)
    82. Catalysis in human hypoxanthine-guanine phosphoribosyltransferase: Asp 137 acts as a general acid/base. (PubMed id 9521733)1, 9 Xu Y. and Grubmeyer C. (1998)
    83. Identification of novel mutations in the human HPRT ge ne. (PubMed id 23473102)1 Nguyen K.V. and Nyhan W.L. (2013)
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    233. Carrier detection of partial hypoxanthine-guanine phosphoribosyltransferase deficiency by analysis with BamHI restriction fragment length polymorphisms and oligonucleotide probes. (PubMed id 1971437)9 Igarashi T. and Kamoshita S. (1990)
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    239. Distinct mechanisms lead to HPRT gene mutations in leukemic cells. (PubMed id 14978792)9 Lin Y.W....Aplan P.D. (2004)
    240. Clarifications on breakpoints in HSAX and BTAX by comparative mapping of F9, HPRT, and XIST in cattle. (PubMed id 14571135)9 Goldammer T....Womack J.E. (2003)
    241. Uneven distributions of naA^ve and memory T cells in t he CD4 and CD8 T-cell populations derived from a single stem cell in an atomic bomb survivor: implications for the origins of the memory T-cell pools in adult hood. (PubMed id 11966314)9 Kusunoki Y....Kyoizumi S. (2002)
    242. Nucleosomes are translationally positioned on the active allele and rotationally positioned on the inactive allele of the HPRT promoter. (PubMed id 11604504)9 Chen C. and Yang T.P. (2001)
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    244. The frequency of illegitimate TCRbeta/gamma gene recombination in human lymphocytes: influence of age, environmental exposure and cytostatic treatment, and correlation with frequencies of t(14;18) and hprt mutation. (PubMed id 10521679)9 Meydan D....Lambert B. (1999)
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    248. Somatic cell gene mutations in humans: biomarkers for genotoxicity. (PubMed id 8143616)9 Albertini R.J....O'Neill J.P. (1993)
    249. Enhanced hprt mutant frequency but no significant difference in mutation spectrum between a smoking and a non-smoking human population. (PubMed id 1394847)9 Vrieling H....van Zeeland A.A. (1992)
    250. Efficient cDNA cloning by direct phenotypic correction of a mutant human cell line (HPRT-) using an Epstein-Barr virus-derived cDNA expression vector. (PubMed id 1656380)9 Belt P.B....Backendorf C. (1991)
    251. Artemia purine phosphoribosyltransferases. Purification and characterization. (PubMed id 1850982)9 Montero C. and Llorente P. (1991)
    252. In vivo hprt mutant frequencies in T-cells of normal human newborns. (PubMed id 2300072)9 McGinniss M.J....Albertini R.J. (1990)
    253. The hypoxanthine-guanine phosphoribosyltransferase of Schistosoma mansoni. Further characterization and gene expression in Escherich ia coli. (PubMed id 2199439)9 Yuan L....Wang C.C. (1990)
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    257. HGPRT mutation induction by N-ethyl-N-nitrosourea as measured by 6-thioguanine resistance is higher in male than in female Syrian ha mster fetuses. (PubMed id 17066413)9 Donovan P.J....Powell D.A. (2006)
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    261. Human sensitivity to 1,3-butadiene: role of microsomal epoxide hydrolase polymorphisms. (PubMed id 11238181)9 Abdel-Rahman S.Z....Ward J.B. (2001)
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    263. Azathioprine associated T-cell mutations in insulin-d ependent diabetes mellitus. (PubMed id 10849375)9 Falta M.T....Albertini R.J. (2000)
    264. Specificity of mutations induced by the food-associated heterocyclic amine 2-amino-1-methyl-6-phenylimidazo-[4,5-b]-pyridine in colon cancer cell lines defective in mismatch repair. (PubMed id 10987307)9 Glaab W.E....Skopek T.R. (2000)
    265. Sequence specific mutations induced by N-nitrosodimethylamine at two marker loci in metabolically competent human lymphoblastoid cells. (PubMed id 9635860)9 Dobo K.L....Grosovsky A.J. (1998)
    266. Resistance to 6-thioguanine in mismatch repair-deficient human cancer cell lines correlates with an increase in induced mutations at the HPRT locus. (PubMed id 9855005)9 Glaab W.E....Tindall K.R. (1998)
    267. Analysis of point mutations in the hprt gene of cancer patients treated with radioimmunoglobulin therapy. (PubMed id 7588646)9 Skandalis A....Glickman B.W. (1995)
    268. The mutagenic processing of psoralen photolesions leaves a highly specific signature at an endogenous human locus. (PubMed id 7473757)9 Laquerbe A....Papadopoulo D. (1995)
    269. Mutation at the HPRT locus in patients with neurocyst icercosis treated with praziquantel. (PubMed id 7510029)9 Montero R....Ostrosky-Wegman P. (1994)
    270. Molecular characterization of methyl methanesulphonat e (MMS)-induced HPRT mutations in V79 cells. (PubMed id 7677946)9 KAPberle B....Speit G. (1993)
    271. Regulation of purine nucleotide synthesis in human B lymphoblasts with both hypoxanthine-guanine phosphoribosyltransferase deficiency and phosphoribosylpyrophosphate synthetase superactivity. (PubMed id 1311306)9 Becker M.A....Kang T. (1992)
    272. Multiple biological markers in germ cell tumor patients treated with platinum-based chemotherapy. (PubMed id 1319825)9 Perera F.P....Jensen R.H. (1992)
    273. X-chromosome inactivation patterns using HPRT and PGK polymorphisms in haematologically normal and post-chemotherapy females. (PubMed id 1958476)9 Gale R.E....Linch D.C. (1991)
    274. Mutations induced by benzo[a]pyrene diolepoxide at the hprt locus in human T-lymphocytes in vitro. (PubMed id 2120584)9 Andersson B. and Lambert B. (1990)
    275. Effect of excision repair by diploid human fibroblasts on the kinds and locations of mutations induced by (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene in the coding region of the HPRT gene. (PubMed id 2122466)9 Chen R.H....McCormick J.J. (1990)
    276. Pyrophosphate activation in hypoxanthine--guanine pho sphoribosyltransferase with transition state analogue. (PubMed id 20170081)9 Deng H....Grubmeyer C. (2010)
    277. Effect of rapid human N-acetyltransferase 2 haplotype on DNA damage and mutagenesis induced by 2-amino-3-methylimidazo-[4,5-f]quinol ine (IQ) and 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline (MeIQx). (PubMed id 20004212)9 Metry K.J....Hein D.W. (2010)
    278. Reference gene selection for head and neck squamous c ell carcinoma gene expression studies. (PubMed id 19650912)9 Lallemant B....Brouillet J.P. (2009)
    279. Effects of dimethyl sulfoxide and dexamethasone on mRNA expression of housekeeping genes in cultures of C2C12 myotubes. (PubMed id 18191039)9 Nishimura M....Ikeda M. (2008)
    280. Urinary guanidinoacetate and creatine levels in patients with HPRT deficiency. (PubMed id 18600507)9 VerdA_ A....Puig J.G. (2008)
    281. HPRT deficiency in a two-month-old child presenting acute renal failure and gout with a new deletion of two bases in exon 3 of the HPRT gene. (PubMed id 17416296)9 Zamora A....O'Neill J.P. (2007)
    282. Commonly used reference genes are actively regulated in in vitro stimulated lymphocytes. (PubMed id 17257226)9 Roge R....Carstens J. (2007)
    283. Partial hypoxanthine-guanine phosphoribosyl transferase deficiency without elevated urinary hypoxanthine excretion. (PubMed id 17129743)9 van Dael C.M....van Spronsen F.J. (2007)
    284. Antimutagenicity of cinnamaldehyde and vanillin in human cells: Global gene expression and possible role of DNA damage and repair. (PubMed id 17178418)9 King A.A....Klein C.B. (2007)
    285. Comparative analysis of the mutagenic activity of oxa liplatin and cisplatin in the Hprt gene of CHO cells. (PubMed id 15887215)9 Silva M.J....Boavida M.G. (2005)
    286. Guanine nucleotide depletion induces differentiation and aberrant neurite outgrowth in human dopaminergic neuroblastoma lines: a model for basal ganglia dysfunction in Lesch-Nyhan disease. (PubMed id 15670649)9 Messina E....Giacomello A. (2005)
    287. Evaluation of housekeeping genes in placental comparative expression studies. (PubMed id 16085039)9 Meller M....Williams M.A. (2005)
    288. Steady-state kinetics of the hypoxanthine phosphoribosyltransferase from Trypanosoma cruzi. (PubMed id 15210120)9 Wenck M.A....Craig S.P. (2004)
    289. Measuring the genetic damage in cancer patients during radiotherapy with three genetic end-points. (PubMed id 15548757)9 Jianlin L....Hongping D. (2004)
    290. The biochemical basis of the neurobehavioral abnormalities in the Lesch-Nyhan syndrome: a hypothesis. (PubMed id 15193365)9 Neychev V.K. and Mitev V.I. (2004)
    291. Biomarkers in Czech workers exposed to 1,3-butadiene: a transitional epidemiologic study. (PubMed id 12931846)9 Albertini R.J....Zwinderman A.H. (2003)
    292. A novel point mutation (I137T) in the conserved 5-phosphoribosyl-1-pyrophosphate binding motif of hypoxanthine-guanine phosphoribosyltransferase (HPRTJerusalem) in a variant of Lesch-Nyhan syndrome. (PubMed id 12618088)9 Zoref-Shani E....Sperling O. (2003)
    293. Molecular analysis of Tripterygium hypoglaucum (level) Hutch-induced mutations at the HPRT locus in human promyelocytic leukemia cells by multiplex polymerase chain reaction. (PubMed id 12473739)9 Liu S.X....An H. (2003)
    294. Purine enzymes in patients with rheumatoid arthritis treated with methotrexate. (PubMed id 12429535)9 van Ede A.E....van de Putte L.B. (2002)
    295. Three somatic genetic biomarkers and covariates in radiation-exposed Russian cleanup workers of the chernobyl nuclear reactor 6-13 years after exposure. (PubMed id 12236810)9 Jones I.M....Nelson D.O. (2002)
    296. Suppression of spontaneous and hydrogen peroxide-induced mutagenesis by the antioxidant ascorbate in mismatch repair-deficient human colon cancer cells. (PubMed id 11577013)9 Glaab W.E....Skopek T.R. (2001)
    297. In vivo mutant frequency of thioguanine-resistant T-cells in the peripheral blood and lymph nodes of melanoma patients. (PubMed id 11336986)9 Albertini M.R....Vacek P.M. (2001)
    298. Effect of mycophenolate mofetil therapy on inosine monophosphate dehydrogenase induction in red blood cells of heart transplant recipients. (PubMed id 11240978)9 Weigel G....Mueller M.M. (2001)
    299. DNA adduct formation and mutant induction in Sprague-Dawley rats treated with tamoxifen and its derivatives. (PubMed id 11470763)9 da Costa G.G....Beland F.A. (2001)
    300. hprt mutant frequencies, nonpulmonary malignancies, and domestic radon exposure: 'postmortem' analysis of an interesting hypothesis. (PubMed id 11170237)9 Ruttenber A.J....Nicklas J.A. (2001)
    301. The genotoxicity of 3-nitrobenzanthrone and the nitropyrene lactones in human lymphoblasts. (PubMed id 11113702)9 Phousongphouang P.T....Arey J. (2000)
    302. Chromosomal aberrations and hprt mutant frequencies in long-term American thorotrast survivors. (PubMed id 10923619)9 Platz E.A....Goldman M.B. (2000)
    303. Molecular analysis of hprt mutant lymphocytes from 1, 3-butadiene-exposed workers. (PubMed id 10918361)9 Ma H....Ward J.B. (2000)
    304. Hprt mutant frequency and aromatic DNA adduct level in non-smoking and smoking lung cancer patients and population controls. (PubMed id 10190559)9 Hou S.M....Lambert B. (1999)
    305. Specificity of mutations induced by methyl methanesulfonate in mismatch repair-deficient human cancer cell lines. (PubMed id 10393261)9 Glaab W.E....Skopek T.R. (1999)
    306. Adenoviruses encoding HPRT correct biochemical abnormalities of HPRT-deficient cells and allow their survival in negative selection medium. (PubMed id 10850548)9 Southgate T.D....LAPwenstein P.R. (1999)
    307. Detection of a novel splice variant of the hypoxanthine-guanine phosphoribosyl transferase gene in human oocytes and preimplantation embryos: implications for a RT-PCR-based preimplantation diagnosis of Lesch-Nyhan syndrome. (PubMed id 9733436)9 Daniels R....Monk M. (1998)
    308. Frequency of HPRT gene mutations induced by N-methyl-N'-nitro-N-nitrosoguanidine corresponds to replication error phenotypes of cell lines. (PubMed id 9626969)9 Zhu W....Mironov N. (1998)
    309. Evaluation of mutant frequencies at the hprt and the T-cell receptor loci in pediatric cancer patients before treatment. (PubMed id 9541658)9 Sawada M....Furusho K. (1998)
    310. Increased somatic recombination in methylation tolerant human cells with defective DNA mismatch repair. (PubMed id 9500919)9 Ciotta C....Bignami M. (1998)
    311. Ion-exchange column chromatographic method for assaying purine metabolic pathway enzymes. (PubMed id 9613962)9 Ward H....Foker J.E. (1998)
    312. Relationship between adduct formation, rates of excision repair and the cytotoxic and mutagenic effects of structurally-related polycyclic aromatic carcinogens. (PubMed id 9202750)9 McGregor W.G....McCormick J.J. (1997)
    313. A study of the effects of exposure on cleanup workers at the Chernobyl nuclear reactor accident using multiple end points. (PubMed id 9355872)9 Moore D.H....Jensen R. (1997)
    314. Deletion and insertion in vivo somatic mutations in the hypoxanthine phosphoribosyltransferase (hprt) gene of human T-lymphocytes. (PubMed id 9435878)9 Burkhart-Schultz K.J. and Jones I.M. (1997)
    315. Mutation rate at the hprt locus in human cancer cell lines with specific mismatch repair-gene defects. (PubMed id 9054582)9 Glaab W.E. and Tindall K.R. (1997)
    316. Transcription of tissue-specific genes in human preimplantation embryos. (PubMed id 9402290)9 Daniels R....Monk M. (1997)
    317. Genetic and cytogenetic markers of exposure to high-linear energy transfer radiation. (PubMed id 9355861)9 Schwartz J.L. and Hsie A.W. (1997)
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    319. Molecular analysis of hypoxanthine guanine phosphoribosyltransferase (HPRT) gene in five Korean families with Lesch-Nyhan syndrome. (PubMed id 9288634)9 Kim K.J....Ogasawara N. (1997)
    320. Spectrum of somatic mutation at the hypoxanthine phosphoribosyltransferase (hprt) gene of healthy people. (PubMed id 8824508)9 Burkhart-Schultz K.J....Jones I.M. (1996)
    321. Biological monitoring for mutagenic effects of occupational exposure to butadiene. (PubMed id 8901886)9 Ward J.B....Legator M.S. (1996)
    322. Alpha particle mutagenesis of human lymphoblastoid cell lines. (PubMed id 8794851)9 Amundson S.A....Okinaka R.T. (1996)
    323. Diverse hypermutability of multiple expressed sequence motifs present in a cancer with microsatellite instability. (PubMed id 8622858)9 Eshleman J.R....Sedwick W.D. (1996)
    324. Mutation rates at the glycophorin A and HPRT loci in uranium miners exposed to radon progeny. (PubMed id 8704866)9 Shanahan E.M....Woodward A. (1996)
    325. Molecular analysis of styrene oxide-induced hprt mutation in human T-lymphocytes. (PubMed id 8962428)9 BastlovA! T. and Podlutsky A. (1996)
    326. A novel de novo mutation in HPRT gene responsible for Lesch-Nyhan syndrome (HPRT OSAKA). (PubMed id 9088115)9 Yamada Y....Ogasawara N. (1996)
    327. Selection against blood cells deficient in hypoxanthine phosphoribosyltransferase (HPRT) in Lesch-Nyhan heterozygotes occurs at the level of multipotent stem cells. (PubMed id 8522326)9 Hakoda M....Kashiwazaki S. (1995)
    328. Mutagenic effects at hprt locus and in minisatellite sequences induced in V79 cells by treatments with UV and methyl-nitro-nitroso guanidine. (PubMed id 8544873)9 Ogheri S....Celotti L. (1995)
    329. Mutational specificity of 2-amino-3-methylimidazo-[4,5-f]quinoline in the hprt locus of CHO-K1 cells. (PubMed id 7605580)9 Lee H. and Shih M.K. (1995)
    330. Mechanistic data indicate that 1,3-butadiene is a human carcinogen. (PubMed id 7859343)9 Melnick R.L. and Kohn M.C. (1995)
    331. Growth rates of hprt and tk mutant CHO cell lines. (PubMed id 7491132)9 Jacobson B.S. and Morgan T.L. (1995)
    332. Spectra of spontaneous and X-ray-induced mutations at the hprt locus in related human lymphoblast cell lines that express wild-type or mutant p53. (PubMed id 7652162)9 Phillips E.N....Liber H.L. (1995)
    333. Site-specific rates of excision repair of benzo[a]pyrene diol epoxide adducts in the hypoxanthine phosphoribosyltransferase gene of human fibroblasts: correlation with mutation spectra. (PubMed id 7892248)9 Wei D....McCormick J.J. (1995)
    334. In vitro mutational spectrum of cyclopenta[cd]pyrene in the human HPRT gene. (PubMed id 7728967)9 Keohavong P....Shukla R. (1995)
    335. Relationship between hprt mutant frequency, aromatic DNA adducts and genotypes for GSTM1 and NAT2 in bus maintenance workers. (PubMed id 7543377)9 Hou S.M....Hemminki K. (1995)
    336. Mutations induced in the hypoxanthine phosphoribosyl transferase gene by three urban air pollutants: acetaldehyde, benzo[a]pyrene diolepoxide, and ethylene oxide. (PubMed id 7821287)9 Lambert B....Kolman A. (1994)
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    338. Chromosomal fragility associated with familial Alzheimer's disease. (PubMed id 8053655)9 Ettinger S....Szabo P. (1994)
    339. Increased frequency of mutations in the hprt gene of T cells isolated from patients with anti-U1-70kD-autoantibody-positive connective tissue disease. (PubMed id 7920025)9 Holyst M.M....Hoffman R.W. (1994)
    340. Demonstration of the X-linkage and order to the genes GLA, G6PD, HPRT, and PGK in two vole species of the genus Microtus. (PubMed id 8258299)9 Nesterova T.B....Zakian S.M. (1994)
    341. The molecular nature of mutations induced by adriamyc in at the hprt locus of V79 cells. (PubMed id 8201943)9 Helbig R....Speit G. (1994)
    342. Coamplification of hprt cDNA and gamma T-cell receptor sequences from 6-thioguanine resistant human T-lymphocytes. (PubMed id 7688087)9 Curry J....Glickman B. (1993)
    343. Measurement of chromosomal aberrations, sister chromatid exchange, hprt mutations, and DNA adducts in peripheral lymphocytes of human populations at increased risk for cancer. (PubMed id 8143603)9 Jacobson-Kram D....Nicklas J.A. (1993)
    344. Human p53, mutated at codon 273, causes distinct effects on nucleotide biosynthesis salvage pathway key enzymes in Rat-1 cells and in their derivatives expressing activated ras oncogene. (PubMed id 8333854)9 Khramtsova S....Kopnin B. (1993)
    345. Clonal haematopoiesis in children with acquired aplastic anaemia. (PubMed id 8338766)9 Tsuge I....Matsuyama T. (1993)
    346. Elevated somatic cell mutant frequencies and altered DNA repair responses in nonsmoking workers exposed to 1,3-butadiene. (PubMed id 8070871)9 Legator M.S....Ward J.B. (1993)
    347. Mutagenicity of 1,3-butadiene and its epoxide metabolites in human TK6 cells and in splenic T cells isolated from exposed B6C3F1 mice. (PubMed id 8070866)9 Cochrane J.E. and Skopek T.R. (1993)
    348. Molecular analysis of ethylene oxide-induced mutations at the HPRT locus in human diploid fibroblasts. (PubMed id 7685488)9 BastlovA! T....Kolman A. (1993)
    349. Failure to obtain hybridomas between human macrophage s and human tumoral U-937 cells is probably due to parental macrophages. (PubMed id 8314731)9 Bohbot A....Poindron P. (1993)
    350. Induction of mutations by bismuth-212 alpha particles at two genetic loci in human B-lymphoblasts. (PubMed id 1475356)9 Metting N.F....Little J.B. (1992)
    351. Preferential repair and strand-specific repair of benzo[a]pyrene diol epoxide adducts in the HPRT gene of diploid human fibroblasts. (PubMed id 1608950)9 Chen R.H....McCormick J.J. (1992)
    352. On the bioactivation and genotoxic action of fluoranthene. (PubMed id 1463388)9 Vaca C....Ehrenberg L. (1992)
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    370. Identification of endogenous control genes for normal isation of real-time quantitative PCR data in colorectal cancer. (PubMed id 20122155)9 Kheirelseid E.A....Miller N. (2010)
    371. Diminished carcinogen detoxification is a novel mecha nism for hypoxia-inducible factor 1-mediated genetic instability. (PubMed id 20228066)9 Schults M.A....Chiu R.K. (2010)
    372. Oxidation reactions of cytosine DNA components by hyd roxyl radical and one-electron oxidants in aerated aqueous solutions. (PubMed id 20078112)9 Wagner J.R. and Cadet J. (2010)
    373. IPO8 and FBXL10: new reference genes for gene express ion studies in human adipose tissue. (PubMed id 19876011)9 Hurtado del Pozo C....Obregon M.J. (2010)
    374. Expression analysis and study of the KLK15 mRNA splic e variants in prostate cancer and benign prostatic hyperplasia. (PubMed id 20067463)9 Mavridis K....Scorilas A. (2010)
    375. Anomalous genotoxic responses induced in mouse lympho ma L5178Y cells by potassium bromate. (PubMed id 19853637)9 Priestley C.C....O'Donovan M.R. (2010)
    376. The effect of endurance training on changes in purine metabolism: a longitudinal study of competitive long-distance runners. (PubMed id 19479277)9 ZieliA8ski J....Laurentowska M. (2009)
    377. Incorporation of 5-chlorocytosine into mammalian DNA results in heritable gene silencing and altered cytosine methylation patterns. (PubMed id 19279184)9 Lao V.V....Sowers L.C. (2009)
    378. Identification of endogenous reference genes for qRT- PCR analysis in normal matched breast tumor tissues. (PubMed id 19544972)9 Gur-Dedeoglu B....Yulug I.G. (2009)
    379. Hypoxanthine-guanine phosphoribosyltransferase from Mycobacterium tuberculosis H37Rv: cloning, expression, and biochemical characterization. (PubMed id 19362594)9 Biazus G....Santos D.S. (2009)
    380. [Study of genetic damage of human B lymphocyte cell l ine induced by 14 nm and 280 nm carbon black particles in vitro] (PubMed id 19497217)9 Deng H.P....Song W.M. (2009)
    381. Role of human CYP1A1 and NAT2 in 2-amino-1-methyl-6-p henylimidazo[4,5-b]pyridine-induced mutagenicity and DNA adducts. (PubMed id 19301197)9 Bendaly J....Hein D.W. (2009)
    382. The Down syndrome critical region gene 1 short varian t promoters direct vascular bed-specific gene expression during inflammation in mice. (PubMed id 19620774)9 Minami T....Kodama T. (2009)
    383. Suicidal function of DNA methylation in age-related g enome disintegration. (PubMed id 19464391)9 Mazin A.L. (2009)
    384. Trypanosoma cruzi targets for new chemotherapeutic approaches. (PubMed id 19063710)9 Soeiro M.N. and de Castro S.L. (2009)
    385. Genomic analysis of cancer tissue reveals that somatic mutations commonly occur in a specific motif. (PubMed id 18623241)9 Makridakis N.M....Reichardt J.K. (2009)
    386. Reverse transcription-quantitative polymerase chain reaction: description of a RIN-based algorithm for accurate data normalization. (PubMed id 19368728)9 Ho-Pun-Cheung A....Lopez-Crapez E. (2009)
    387. Lesch-Nyhan disease: from mechanism to model and back again. (PubMed id 19259384)9 Jinnah H.A. (2009)
    388. Inhibition of erythrocyte phosphoribosyltransferases (APRT and HPRT) by Pb2+: a potential mechanism of lead toxicity. (PubMed id 19428946)9 Baranowska-Bosiacka I....Chlubek D. (2009)
    389. Non-linear dose-response of DNA-reactive genotoxins: Recommendations for data analysis. (PubMed id 19467345)9 Johnson G.E....Jenkins G.J. (2009)
    390. Selection of reference genes for normalisation of rea l-time RT-PCR in brain-stem death injury in Ovis aries. (PubMed id 19624860)9 Passmore M....Fraser J.F. (2009)
    391. Abnormal adenosine and dopamine receptor expression i n lymphocytes of Lesch-Nyhan patients. (PubMed id 19635551)9 GarcA-a M.G....Torres R.J. (2009)
    392. Myelination disturbance in a patient with hyperuricem ia and hyperserotoninemia combined with 18q deletion syndrome. (PubMed id 20025132)9 LA!szlA^ A....Patterson M.C. (2009)
    393. Radiation-quality dependent cellular response in muta tion induction in normal human cells. (PubMed id 19680011)9 Suzuki M....Liu C.H. (2009)
    394. Severe gouty arthritis and mild neurologic symptoms d ue to F199C, a newly identified variant of the hypoxanthine guanine phosphoribo syltransferase. (PubMed id 19565499)9 Ea H.K....Ceballos-Picot I. (2009)
    395. NAD metabolism in HPRT-deficient mice. (PubMed id 19319672)9 Micheli V....Jinnah H.A. (2009)
    396. Modulation of psoralen DNA crosslinking kinetics associated with a triplex-forming oligonucleotide. (PubMed id 18435621)9 Oh D.H....Krishnan R. (2008)
    397. Determinants of sensitivity of human T-cell leukemia CCRF-CEM cells to immucillin-H. (PubMed id 18279955)9 Huang M....Graves L.M. (2008)
    398. Is ZMP the toxic metabolite in Lesch-Nyhan disease? (PubMed id 18710792)9 Lopez J.M. (2008)
    399. Both replication bypass fidelity and repair efficiency influence the yield of mutations per target dose in intact mammalian cells induced by benzo[a]pyrene-diol-epoxide and dibenzo[a,l]pyrene-diol-epoxide. (PubMed id 18479980)9 Lagerqvist A....Jenssen D. (2008)
    400. Partial hypoxanthine-guanine phosphoribosyltransferase deficiency due to a newly recognized mutation presenting with renal failure in a one-year-old boy. (PubMed id 17891542)9 Ishida Y....Yamada Y. (2008)
    401. Relevance of experimental models for investigation of genotoxicity induced by antiretroviral therapy during human pregnancy. (PubMed id 18295533)9 Olivero O.A. (2008)
    402. Exercise induced stress in horses: selection of the most stable reference genes for quantitative RT-PCR normalization. (PubMed id 18489742)9 Cappelli K....Supplizi A.V. (2008)
    403. Acetaldehyde-induced mutational pattern in the tumour suppressor gene TP53 analysed by use of a functional assay, the FASAY (functional analysis of separated alleles in yeast). (PubMed id 18242117)9 Paget V....Sichel F. (2008)
    404. Quantitative Real-Time PCR detection of TRPV1-4 gene expression in human leukocytes from healthy and hyposensitive subjects. (PubMed id 18983665)9 Spinsanti G....Aloisi A.M. (2008)
    405. Lesch-Nyhan syndrome presenting with acute renal failure in a 3-day-old newborn. (PubMed id 17701224)9 Pela I....Fiorini P. (2008)
    406. Validation of internal control genes for expression studies: effects of the neurotrophin BDNF on hippocampal neurons. (PubMed id 18655199)9 Santos A.R. and Duarte C.B. (2008)
    407. Role of DNA polymerases eta, iota and zeta in UV resistance and UV-induced mutagenesis in a human cell line. (PubMed id 18586118)9 Gueranger Q....Weill J.C. (2008)
    408. Validation of putative reference genes for gene expression studies in human hepatocellular carcinoma using real-time quantitative RT-PCR. (PubMed id 19036168)9 Cicinnati V.R....Beckebaum S. (2008)
    409. Selection of reference genes for real-time PCR in human hepatocellular carcinoma tissues. (PubMed id 18317805)9 Gao Q....Sun J. (2008)
    410. [Definition and classification of hyperuricemia] (PubMed id 18409507)9 Yamamoto T. (2008)
    411. Temporally controlled prostate epithelium-specific ge ne alterations. (PubMed id 18395839)9 Luchman H.A....Jirik F.R. (2008)
    412. Unusual presentation of Kelley-Seegmiller syndrome. (PubMed id 18600521)9 Sebesta I....Rychlik I. (2008)
    413. Clonal expansions of 6-thioguanine resistant T lymphocytes in the blood and tumor of melanoma patients. (PubMed id 18712786)9 Albertini M.R....Albertini R.J. (2008)
    414. Application of metabolomic principles to disorders of nucleotide metabolism reveals new metabolic perturbations. (PubMed id 18600520)9 Snyder F.F....Mantik K.B. (2008)
    415. Protective efficacy of hGSTM1-1 against B[a]P and (+)- or (-)-B[a]P-7,8-dihydrodiol cytotoxicity, mutagenicity, and macromolecular adducts in V79 cells coexpressing hCYP1A1. (PubMed id 17525473)9 Kushman M.E....Townsend A.J. (2007)
    416. High level glucose increases mutagenesis in human lymphoblastoid cells. (PubMed id 17848982)9 Zhang Y....Cai L. (2007)
    417. Relative quantification of mRNA: comparison of methods currently used for real-time PCR data analysis. (PubMed id 18093344)9 Cikos S....Koppel J. (2007)
    418. Mutagenicity of zidovudine, lamivudine, and abacavir following in vitro exposure of human lymphoblastoid cells or in utero exposure of CD-1 mice to single agents or drug combinations. (PubMed id 17358033)9 Torres S.M....Walker V.E. (2007)
    419. Mutagenicity of stereochemical configurations of 1,2-epoxybutene and 1,2:3,4-diepoxybutane in human lymphblastoid cells. (PubMed id 16854403)9 Meng Q....Walker V.E. (2007)
    420. 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine-induced DNA adducts and genotoxicity in chinese hamster ovary (CHO) cells expressing human CYP1A2 and rapid or slow acetylator N-acetyltransferase 2. (PubMed id 17295238)9 Metry K.J....Hein D.W. (2007)
    421. Expression of human glutathione S-transferase P1 confers resistance to benzo[a]pyrene or benzo[a]pyrene-7,8-dihydrodiol mutagenesis, macromolecular alkylation and formation of stable N2-Gua-BPDE adducts in stably transfected V79MZ cells co-expressing hCYP1A1. (PubMed id 16885195)9 Kushman M.E....Townsend A.J. (2007)
    422. Effects of 2.45 GHz electromagnetic fields with a wid e range of SARs on bacterial and HPRT gene mutations. (PubMed id 17179647)9 Koyama S....Miyakoshi J. (2007)
    423. Significance of CpG methylation for solar UV-induced mutagenesis and carcinogenesis in skin. (PubMed id 16620158)9 Ikehata H. and Ono T. (2007)
    424. A human neuronal tissue culture model for Lesch-Nyhan disease. (PubMed id 17448149)9 Shirley T.L....Jinnah H.A. (2007)
    425. Detoxification of olefinic epoxides and nucleotide excision repair of epoxide-mediated DNA damage: Insights from animal models examining human sensitivity to 1,3-butadiene. (PubMed id 16730686)9 Wickliffe J.K....Ward J.B. (2007)
    426. Application of HPLC to study the kinetics of a branched bi-enzyme system consisting of hypoxanthine-guanine phosphoribosyltransferase and xanthine oxidase--an important biochemical system to evaluate the efficiency of the anticancer drug 6-mercaptopurine in ALL cell line. (PubMed id 17081813)9 Kalra S....Mukhopadhyay A.K. (2007)
    427. Identifying the most suitable endogenous control for determining gene expression in hearts from organ donors. (PubMed id 18096027)9 PAcrez S....Otero J. (2007)
    428. Relationship between the capacity to repair 8-oxoguanine, biomarkers of genotoxicity and individual susceptibility in styrene-exposed workers. (PubMed id 17855160)9 Slyskova J....Vodicka P. (2007)
    429. Triethylene glycol HO(CH2CH2O)3H. (PubMed id 17299811)9 Ballantyne B. and Snellings W.M. (2007)
    430. Partial characterization of the proteome of the mouse striatum. (PubMed id 17922512)9 Guo L.T....King C.C. (2007)
    431. ATF4-dependent oxidative induction of the DNA repair enzyme Ape1 counteracts arsenite cytotoxicity and suppresses arsenite-mediated mutagenesis. (PubMed id 17938202)9 Fung H....Demple B. (2007)
    432. Selection of reliable reference genes for qPCR studies on chondroprotective action. (PubMed id 17324259)9 Toegel S....Viernstein H. (2007)
    433. Elevated levels of somatic mutation in a manifesting BRCA1 mutation carrier. (PubMed id 18158561)9 Grant S.G....Latimer J.J. (2007)
    434. Frequency of Hprt mutant lymphocytes and micronucleat ed erythrocytes in p53-haplodeficient mice treated perinatally with AZT and AZT in combination with 3TC. (PubMed id 17358030)9 Dobrovolsky V.N....Heflich R.H. (2007)
    435. Hypoxanthine decreases equilibrative type of adenosine transport in lymphocytes from Lesch-Nyhan patients. (PubMed id 17883419)9 Prior C....Puig J.G. (2007)
    436. Mechanisms of genotoxicity of nucleoside reverse transcriptase inhibitors. (PubMed id 16395695)9 Olivero O.A. (2007)
    437. Formation of lysine 63-linked poly-ubiquitin chains protects human lung cells against benzo[a]pyrene-diol-epoxide-induced mutagenicity. (PubMed id 17395554)9 Langie S.A....Chiu R.K. (2007)
    438. Successful downstream application of the Paxgene Bloo d RNA system from small blood samples in paediatric patients for quantitative P CR analysis. (PubMed id 17850649)9 Carrol E.D....Day P. (2007)
    439. Validation of endogenous controls for quantitative gene expression analysis: application on brain cortices of human chronic alcoholics. (PubMed id 17188656)9 Johansson S....Ekstrom T.J. (2007)
    440. Increased mutant frequencies in the HPRT gene locus of leukemia HL-60 cells treated with succinylacetone. (PubMed id 16838078)9 Zheng K.C....Keohavong P. (2006)
    441. Utility of proteomics to assess pollutant response of clams from the DoA+ana bank of Guadalquivir Estuary (SW Spain). (PubMed id 16544285)9 Romero-Ruiz A....LA^pez-Barea J. (2006)
    442. Molecular analysis of hprt mutations induced by chrom ium picolinate in CHO AA8 cells. (PubMed id 16877033)9 Coryell V.H. and Stearns D.M. (2006)
    443. Acute renal failure due to bilateral xanthine urolithiasis in a boy with Lesch-Nyhan syndrome. (PubMed id 16773422)9 Sikora P....Zajczkowska M. (2006)
    444. Quantification of N-(deoxyguanosin-8-yl)-4-aminobiphenyl adducts in human lymphoblastoid TK6 cells dosed with N-hydroxy-4-acetylaminobiphenyl and their relationship to mutation, toxicity, and gene expression profiling. (PubMed id 16970317)9 Ricicki E.M....Vouros P. (2006)
    445. [Complex cytogenetic characteristic of people suffered from Chernobyl accident] (PubMed id 16756111)9 Vorobtsova I.E. and Semenov A.V. (2006)
    446. Activation of the purine salvage pathway in mononuclear cells of cardiac recipients treated with mycophenolate mofetil. (PubMed id 16861950)9 Devyatko E....Weigel G. (2006)
    447. Decreased GTP-stimulated adenylyl cyclase activity in HPRT-deficient human and mouse fibroblast and rat B103 neuroblastoma cell membranes. (PubMed id 16336632)9 Pinto C.S. and Seifert R. (2006)
    448. Colostrinin decreases spontaneous and induced mutatio n frequencies at the hprt locus in Chinese hamster V79 cells. (PubMed id 17024966)9 Bacsi A....Boldogh I. (2006)
    449. Delineation of the motor disorder of Lesch-Nyhan disease. (PubMed id 16549399)9 Jinnah H.A....Reich S.G. (2006)
    450. Efficacy and safety of allopurinol in patients with the Lesch-Nyhan syndrome and partial hypoxanthine- phosphoribosyltransferase deficiency: a follow-up study of 18 Spanish patients. (PubMed id 17065067)9 Torres R.J....Puig J.G. (2006)
    451. Lesch-Nyhan disease in a 20-year- old man incorrectly described as developing 'cerebral palsy' after general anaesthesia in infancy. (PubMed id 16826447)9 Chiong M.A....Christodoulou J. (2006)
    452. Molecular, biochemical, and genetic characterization of a female patient with Lesch-Nyhan disease. (PubMed id 16343967)9 Rinat C....Frishberg Y. (2006)
    453. Selection of housekeeping genes for gene expression studies in human reticulocytes using real-time PCR. (PubMed id 17026756)9 Silver N....Thein S.L. (2006)
    454. Quantitative multi-gene expression profiling of primary prostate cancer. (PubMed id 16921506)9 Schmidt U....Meye A. (2006)
    455. Analysis of mutagenic V(D)J recombinase mediated mutations at the HPRT locus as an in vivo model for studying rearrangements with leukemogenic potential in children. (PubMed id 16807138)9 Finette B.A. (2006)
    456. Stability of housekeeping genes in alveolar macrophages from COPD patients. (PubMed id 16452584)9 Ishii T....Sandford A.J. (2006)
    457. Stable expression of a heterogeneous gene introduced via gene targeting into the HPRT locus of human fibrosarcoma cells. (PubMed id 16807926)9 Koyama Y....Kusano K. (2006)
    458. Partial HPRT deficiency (Kelley-Seegmiller syndrome). (PubMed id 16649740)9 Saigal R....Prashant R.K. (2006)
    459. Behavioural and hypothalamic molecular effects of the anti-cancer agent cisplatin in the rat: A model of chemotherapy-related malaise? (PubMed id 16443263)9 Malik N.M....Andrews P.L. (2006)
    460. Atlantoaxial subluxation with recurrent consciousness disturbance in a boy with Lesch-Nyhan syndrome. (PubMed id 17062485)9 Hou J.W. (2006)
    461. A comparative QM/MM simulation study of the reaction mechanisms of human and Plasmodium falciparum HG(X)PRTases. (PubMed id 16881638)9 Thomas A. and Field M.J. (2006)
    462. Identification and validation of suitable endogenous reference genes for gene expression studies of human bladder cancer. (PubMed id 16600798)9 Ohl F....Jung K. (2006)
    463. Enhanced gene targeting efficiency by siRNA that silences the expression of the Bloom syndrome gene in human cells. (PubMed id 16611240)9 So S....Koyama H. (2006)
    464. Genotoxicity of acrylamide and its metabolite glycidamide administered in drinking water to male and female Big Blue mice. (PubMed id 15957192)9 Manjanatha M.G....Doerge D.R. (2006)
    465. Proteomic analysis of Down's syndrome patients with gout. (PubMed id 16500633)9 Chen Y.C....Chen C.J. (2006)
    466. Hypoxanthine effect on equilibrative and concentrative adenosine transport in human lymphocytes: implications in the phatogenesis of Lesch-Nyhan syndrome. (PubMed id 17065065)9 Prior C....Puig J.G. (2006)
    467. A human cell-based assay to evaluate the effects of alterations in the MLH1 mismatch repair gene. (PubMed id 16982745)9 Blasi M.F....Bignami M. (2006)
    468. Acrylamide and glycidamide: genotoxic effects in V79-cells and human blood. (PubMed id 15668108)9 Baum M....Eisenbrand G. (2005)
    469. Hypothesized deficiency of guanine-based purines may contribute to abnormalities of neurodevelopment, neuromodulation, and neurotransmission in Lesch-Nyhan syndrome. (PubMed id 15711436)9 Deutsch S.I....Eller J. (2005)
    470. Growth of V79 cells as xenograft tumors promotes multicellular resistance but does not increase spontaneous or radiation-induced mutant frequency. (PubMed id 16296879)9 BanA!th J.P....Olive P.L. (2005)
    471. Variability in human sensitivity to 1,3-butadiene: influence of polymorphisms in the 5'-flanking region of the microsomal epoxide hydrolase gene (EPHX1). (PubMed id 15716486)9 Abdel-Rahman S.Z....Ward J.B. (2005)
    472. Methods for detecting somatic mutations in vitro: the human T-cell cloning assay selecting for HPRT mutants. (PubMed id 15502220)9 Hou S.M. (2005)
    473. Normalization of gene expression measurements in tumor tissues: comparison of 13 endogenous control genes. (PubMed id 15543203)9 de Kok J.B....Span P.N. (2005)
    474. Somatic mutant frequency at the HPRT locus in children associated with a pediatric cancer cluster linked to exposure to two superfund sites. (PubMed id 15657919)9 Vacek P.M....Finette B.A. (2005)
    475. Gene expression studies in prostate cancer tissue: which reference gene should be selected for normalization? (PubMed id 16211407)9 Ohl F....Jung K. (2005)
    476. NBS1 knockdown by small interfering RNA increases ionizing radiation mutagenesis and telomere association in human cells. (PubMed id 15994926)9 Zhang Y....Liber H.L. (2005)
    477. [Investigating genetic damage of workers occupational ly exposed to methotrexate] (PubMed id 16405770)9 Deng H.P....Wang B.H. (2005)
    478. HPRT deficiency as the cause of ESRD in a 24-year-old patient: a very rare presentation of the disorder. (PubMed id 16245252)9 Kassimatis T.I....Diamandopoulos A.A. (2005)
    479. A comparison of somatic mutational spectra in healthy study populations from Russia, Sweden and USA. (PubMed id 15731167)9 Noori P....Lambert B. (2005)
    480. DNA repair and cyclin D1 polymorphisms and styrene-induced genotoxicity and immunotoxicity. (PubMed id 15992842)9 Kuricova M....Vodicka P. (2005)
    481. Eighteen-year follow-up of a patient with partial hypoxanthine phosphoribosyltransferase deficiency and a new mutation. (PubMed id 15965771)9 Gregoric A....Zagradisnik B. (2005)
    482. Molecular analysis of mutations in the human HPRT gen e. (PubMed id 15502221)9 Keohavong P....Grant S.G. (2005)
    483. Plasmodium falciparum hypoxanthine guanine phosphoribosyltransferase. Stability studies on the product-activated enzyme. (PubMed id 15819884)9 Raman J....Balaram H. (2005)
    484. Hereditary hyperuricemia and renal disease. (PubMed id 15660329)9 Cameron J.S. and Simmonds H.A. (2005)
    485. Deletion of mouse rad9 causes abnormal cellular responses to DNA damage, genomic instability, and embryonic lethality. (PubMed id 15282322)9 Hopkins K.M....Lieberman H.B. (2004)
    486. Expression pattern of X-linked genes in sex chromosome aneuploid bovine cells. (PubMed id 15125640)9 Basrur P.K....King W.A. (2004)
    487. Identification of a new point mutation in hypoxanthine phosphoribosyl transferase responsible for hyperuricemia in a female patient. (PubMed id 15536609)9 Inokuchi T....Yamamoto T. (2004)
    488. A recombinant model for assessing the role of GSTM1 in styrene-7,8-oxide toxicity and mutagenicity. (PubMed id 14698568)9 Shield A.J. and Sanderson B.J. (2004)
    489. Tetrahydrobiopterin deficiency and dopamine loss in a genetic mouse model of Lesch-Nyhan disease. (PubMed id 15159647)9 Hyland K....Jinnah H.A. (2004)
    490. Bilirubin UDP-glucuronosyltransferase 1A1 (UGT1A1) gene promoter polymorphisms and HPRT, glycophorin A, and micronuclei mutant frequencies in human blood. (PubMed id 15099818)9 Grant D.J....Bell D.A. (2004)
    491. The mutagenic hazards of aquatic sediments: a review. (PubMed id 15572285)9 Chen G. and White P.A. (2004)
    492. A novel missense mutation, c.584A > C (Y195S), in two unrelated Argentine patients with hypoxanthine-guanine phosphoribosyl-trans ferase deficiency, neurological variant. (PubMed id 15059624)9 LarA^vere L.E....de Kremer R.D. (2004)
    493. Analysis of microsatellite instability in children treated for acute lymphocytic leukemia with elevated HPRT mutant frequencies. (PubMed id 15388815)9 Kendall H.E....Finette B.A. (2004)
    494. The oxidized deoxynucleoside triphosphate pool is a s ignificant contributor to genetic instability in mismatch repair-deficient cell s. (PubMed id 14673178)9 Russo M.T....Bignami M. (2004)
    495. Are allopurinol and metabolites found in HPRT deficie nt erythrocytes responsible for increased NAD synthesis? (PubMed id 15571228)9 Micheli V....Pompucci G. (2004)
    496. Frequency of Tk and Hprt lymphocyte mutants and bone marrow micronuclei in mice treated neonatally with zidovudine and didanosine. (PubMed id 15215330)9 Von Tungeln L.S....Beland F.A. (2004)
    497. Kelley-Seegmiller syndrome due to a new variant of the hypoxanthine-guanine phosphoribosyltransferase (I136T) encoding gene (HPRT Marseille). (PubMed id 15334740)9 Dussol B....Berland Y. (2004)
    498. Mutation carrier testing in Lesch-Nyhan syndrome fami lies: HPRT mutant frequency and mutation analysis with peripheral blood T lymph ocytes. (PubMed id 15140374)9 O'Neill J.P. (2004)
    499. Equivalence test in quantitative reverse transcription polymerase chain reaction: confirmation of reference genes suitable for normalization. (PubMed id 15519565)9 Haller F....FA1zesi L. (2004)
    500. Thiopurine methyltransferase: should it be measured before commencing thiopurine drug therapy? (PubMed id 15298741)9 Sanderson J....Duley J. (2004)
    501. The mutagenic potentiator effect of chlorophyllin by the HGPRT assay. (PubMed id 14630073)9 Davidson Negraes P....Mantovani M.S. (2004)
    502. Embryonic stem cells expressing expanded CAG repeats undergo aberrant neuronal differentiation and have persistent Oct-4 and REST/NRSF expression. (PubMed id 15121185)9 Lorincz M.T....O'Shea K.S. (2004)
    503. Saturation mutagenesis, complement selection, and steady-state kinetic studies illuminate the roles of invariant residues in active site loop I of the hypoxanthine phosphoribosyltransferase from Trypanosoma cruzi. (PubMed id 15158715)9 Butterworth A.C....Craig S.P. (2004)
    504. Adenosine transport in HPRT deficient lymphocytes from Lesch-Nyhan disease patients. (PubMed id 15571229)9 Torres R.J....Puig J.G. (2004)
    505. Adenosine transport in peripheral blood lymphocytes f rom Lesch-Nyhan patients. (PubMed id 14572307)9 Torres R.J....Puig J.G. (2004)
    506. Genotoxicity of tobacco smoke and tobacco smoke condensate: a review. (PubMed id 15572290)9 DeMarini D.M. (2004)
    507. LET and ion-species dependence for mutation induction and mutation spectrum on hprt locus in normal human fibroblasts. (PubMed id 15858385)9 Tsuruoka C....Fujitaka K. (2004)
    508. Case report: the Lesch-Nyhan syndrome. (PubMed id 15202925)9 Benz C.M....Agostini F.G. (2004)
    509. Metallothionein-III prevents gamma-ray-induced 8-oxoguanine accumulation in normal and hOGG1-depleted cells. (PubMed id 15190073)9 Jeong H.G....You H.J. (2004)
    510. Role of the promoter in maintaining transcriptionally active chromatin structure and DNA methylation patterns in vivo. (PubMed id 12773559)9 Kang S.H....Yang T.P. (2003)
    511. Variability in human sensitivity to 1,3-butadiene: In fluence of the allelic variants of the microsomal epoxide hydrolase gene. (PubMed id 12605384)9 Abdel-Rahman S.Z....Ward J.B. (2003)
    512. [Effect of morphine on expression of gene of enzymes related to purine nucleotide metabolism in c6 glioma] (PubMed id 12757645)9 Liu J.K....Zhao X.D. (2003)
    513. Chemical diagnosis of Lesch-Nyhan syndrome using gas chromatography-mass spectrometry detection. (PubMed id 12829005)9 Ohdoi C....Kuhara T. (2003)
    514. Bromate induces loss of heterozygosity in the thymidine kinase gene of L5178Y/Tk(+/-)-3.7.2C mouse lymphoma cells. (PubMed id 12742504)9 Harrington-Brock K....Chen T. (2003)
    515. Genetic toxicity of methamphetamine in vitro and in human abusers. (PubMed id 14673868)9 Li J.H....Lin S.K. (2003)
    516. Genetic damage induced by in vitro irradiation of human G0 lymphocytes with low-energy protons (28 keV/microm): HPRT mutations and chromosome aberrations. (PubMed id 12816523)9 Mognato M....Celotti L. (2003)
    517. APRT from erythrocytes of HGPRT deficient patients: kinetic, regulatory and thermostability properties. (PubMed id 14674717)9 Crespillo J....Montero C. (2003)
    518. Chromosomal integration and homologous gene targeting by replication-incompetent vectors based on the autonomous parvovirus minute v irus of mice. (PubMed id 14645570)9 Hendrie P.C....Russell D.W. (2003)
    519. Disappearance of self-mutilating behavior in a patient with lesch-nyhan syndrome after bilateral chronic stimulation of the globus pallidus internus. Case report. (PubMed id 12593632)9 Taira T....Hori T. (2003)
    520. Optimization of quantitative real-time RT-PCR parameters for the study of lymphoid malignancies. (PubMed id 12682639)9 Lossos I.S....Levy R. (2003)
    521. Nucleocytoplasmic transport signals affect the age at onset of abnormalities in knock-in mice expressing polyglutamine within an ect opic protein context. (PubMed id 12812988)9 Jackson W.S....Detloff P.J. (2003)
    522. Dietary fruit and vegetables protect against somatic mutation in vivo, but low or high intake of carotenoids does not. (PubMed id 12727797)9 Nyberg F....Lambert B. (2003)
    523. Ionic states of substrates and transition state analogues at the catalytic sites of N-ribosyltransferases. (PubMed id 12741826)9 Sauve A.A....Schramm V.L. (2003)
    524. Analysis of spontaneous, gamma ray- and ethylnitrosourea-induced hprt mutants in HL-60 cells with multiplex PCR. (PubMed id 12632522)9 Liu S.X....Liu Y. (2003)
    525. Purine and pyrimidine metabolites in children's urine. (PubMed id 12927681)9 Vidotto C....MA1ller M.M. (2003)
    526. Development of an HIV-based cDNA expression cloning system. (PubMed id 12842440)9 van Maanen M....Sutton R.E. (2003)
    527. Response of human REV3 gene to gastric cancer inducing carcinogen N-methyl-N'-nitro-N-nitrosoguanidine and its role in mutagenesis. (PubMed id 12717825)9 Zhu F....Yu Y.N. (2003)
    528. LET and ion-species dependence for cell killing and m utation induction in normal human fibroblasts. (PubMed id 14676365)9 Tsuruoka C....Fujitaka K. (2003)
    529. Selectable system for monitoring the instability of C TG/CAG triplet repeats in mammalian cells. (PubMed id 12808091)9 Gorbunova V....Wilson J.H. (2003)
    530. Minisatellite and Hprt mutations in V79 cells irradia ted with helium ions and gamma rays. (PubMed id 12428920)9 Cherubinit R....Celotti L. (2002)
    531. [Treatment of Lesch-Nyhan syndrome] (PubMed id 12436387)9 De Antonio I....GarcA-a-Puig J. (2002)
    532. Genetic toxicology studies with glutaraldehyde. (PubMed id 11807929)9 Vergnes J.S. and Ballantyne B. (2002)
    533. Modulation of the DNA damage response in UV-exposed h uman lymphoblastoid cells through genetic-versus functional-inactivation of the p53 tumor suppressor. (PubMed id 12376471)9 LAcger C. and Drobetsky E.A. (2002)
    534. Partial hypoxanthine-Guanine phosphoribosyltransferase deficiency as the unsuspected cause of renal disease spanning three generations: a cautionary tale. (PubMed id 11773585)9 Augoustides-Savvopoulou P....Simmonds H.A. (2002)
    535. Base substitutions, targeted single-base deletions, a nd chromosomal translocations induced by bleomycin in plateau-phase mammary epi thelial cells. (PubMed id 12175310)9 Yu Y....Povirk L.F. (2002)
    536. Silencing expression of the catalytic subunit of DNA-dependent protein kinase by small interfering RNA sensitizes human cells for radiation-induced chromosome damage, cell killing, and mutation. (PubMed id 12438223)9 Peng Y....Bedford J.S. (2002)
    537. New aspects in the biomonitoring of occupational exposure to styrene. (PubMed id 12397415)9 Vodicka P....Hemminki K. (2002)
    538. Kelley-Seegmiller syndrome in a patient with complete hypoxanthine-guanine phosphoribosyltransferase deficiency. (PubMed id 12508781)9 Cossu A....Carcassi A. (2002)
    539. The mutational signature of alpha-hydroxytamoxifen at Hprt locus in Chinese hamster cells. (PubMed id 12419845)9 Yadollahi-Farsani M....Boobis A.R. (2002)
    540. Biochemical and molecular study of mentally retarded patient with partial deficiency of hypoxanthine-guanine phosphoribosyltransferase. (PubMed id 12009423)9 Micheli V....Pompucci G. (2002)
    541. Genotoxicity, mitochondrial damage, and apoptosis in human lymphoblastoid cells exposed to peroxynitrite generated from SIN-1. (PubMed id 11952339)9 Li C.Q....Wogan G.N. (2002)
    542. Aphidicolin induces 6-thioguanine resistant mutants i n human diploid fibroblasts. (PubMed id 11827715)9 Kolman A....GrawAc J. (2002)
    543. Improved sample preparation of biomaterials for in vitro genotoxicity testing using reference materials. (PubMed id 12001250)9 MA1ller B.P....Hollender J. (2002)
    544. Simple non-radiochemical HPLC-linked method for screening for purine metabolism disorders using dried blood spot. (PubMed id 12204435)9 Jacomelli G....Pompucci G. (2002)
    545. Differential patterns of histone methylation and acetylation distinguish active and repressed alleles at X-linked genes. (PubMed id 12900547)9 Goto Y....Feil R. (2002)
    546. Single nucleotide instability: a wide involvement in human and rat mammary carcinogenesis? (PubMed id 12351149)9 Okochi E....Ushijima T. (2002)
    547. Effect of ethylnitrosourea on HPRT gene in human promyelocytic leukemia cells. (PubMed id 12410959)9 Liu S....An H. (2002)
    548. Frequency of Tk and Hprt lymphocyte mutants and bone marrow micronuclei in B6C3F(1)/Tk+/- mice treated neonatally with zidovudine and lamivudine. (PubMed id 12189183)9 Von Tungeln L.S....Beland F.A. (2002)
    549. The unexpected landscape of in vivo somatic mutation in a human epithelial cell lineage. (PubMed id 11818556)9 Colgin L.M....Monnat R.J. (2002)
    550. Control genes and variability: absence of ubiquitous reference transcripts in diverse mammalian expression studies. (PubMed id 11827948)9 Lee P.D....Hudson T.J. (2002)
    551. Pharmacokinetic considerations in the treatment of inflammatory bowel disease. (PubMed id 11707060)9 Schwab M. and Klotz U. (2001)
    552. A one-step gene amplification system for use in cultu red mammalian cells and transgenic animals. (PubMed id 11305360)9 Melton D.W....Selfridge J. (2001)
    553. Neurocognitive functioning in Lesch-Nyhan disease and partial hypoxanthine-guanine phosphoribosyltransferase deficiency. (PubMed id 11771623)9 Schretlen D.J....del Pozo N.O. (2001)
    554. Real-time RT-PCR for the detection of beta-adrenoceptor messenger RNAs in small human endomyocardial biopsies. (PubMed id 11735259)9 Moniotte S....Balligand J.L. (2001)
    555. Role of glutathione S-transferase mu (GSTM1) in styrene-7,8-oxide toxicity and mutagenicity. (PubMed id 11424177)9 Shield A.J. and Sanderson B.J. (2001)
    556. [The Lesch-Nyhan syndrome] (PubMed id 11928606)9 Peco-AntiA8 A....KrusciA8 D. (2001)
    557. Accumulation of somatic mutations in proliferating T cell clones from children treated for leukemia. (PubMed id 11753611)9 Finette B.A....Albertini R.J. (2001)
    558. Genetic and reproductive toxicity of butadiene and isoprene. (PubMed id 11397382)9 Anderson D. (2001)
    559. Analysis of mutational effects at the HPRT locus in h uman G(0) phase lymphocytes irradiated in vitro with gamma rays. (PubMed id 11239972)9 Mognato M....Celotti L. (2001)
    560. Working condition-related improvement in genotoxicological parameters of Hungarian road pavers. (PubMed id 11261895)9 Major J....Tompa A. (2001)
    561. The effect of folate deficiency on the cytotoxic and mutagenic responses to ethyl methanesulfonate in human lymphoblastoid cell line s that differ in p53 status. (PubMed id 11166026)9 Branda R.F....Nicklas J.A. (2001)
    562. Evaluation of three somatic genetic biomarkers as indicators of low dose radiation effects in clean-up workers of the Chernobyl nuclear reactor accident. (PubMed id 11763359)9 Jones I.M....Nelson D.O. (2001)
    563. Intravitreal invading cells contribute to vitreal cytokine milieu in proliferative vitreoretinopathy. (PubMed id 11264138)9 El-Ghrably I.A....Tighe P.J. (2001)
    564. Hypoxanthine impairs morphogenesis and enhances proliferation of a neuroblastoma model of Lesch Nyhan syndrome. (PubMed id 11241585)9 Ma M.H....Connolly G.P. (2001)
    565. Biomarkers for assessing occupational exposures to 1,3-butadiene. (PubMed id 11397405)9 Albertini R.J....Ward J.B. (2001)
    566. Cell killing and mutation induction by heavy ion beam s. (PubMed id 11295113)9 Shigematsu N....Ito H. (2001)
    567. Gestational age and gender-specific in utero V(D)J recombinase-mediated deletions. (PubMed id 11309304)9 Yoshioka M....Finette B.A. (2001)
    568. Synergistic effect of cadmium chloride and acetaldehy de on cytotoxicity and its prevention by quercetin and glycyrrhizin. (PubMed id 11551487)9 Hu C.C....Lee Y.J. (2001)
    569. Hypoxanthine-guanine phosphoribosyltransferase-deficiency produces aberrant neurite outgrowth of rodent neuroblastoma used to model the neurological disorder Lesch Nyhan syndrome. (PubMed id 11698147)9 Connolly G.P. (2001)
    570. Abnormal development of hypoxanthine-guanine phosphoribosyltransferase-deficient CNS neuroblastoma. (PubMed id 11684038)9 Connolly G.P....Stacey N.C. (2001)
    571. Assays to predict the genotoxicity of the chromosomal mutagen etoposide -- focussing on the best assay. (PubMed id 11516723)9 Turner S.D....Fairbairn L.J. (2001)
    572. Comparison of the mutagenic responses of mismatch repair-proficient (TK6) and mismatch repair-deficient (MT1) human lymphoblast cells to the food-borne carcinogen PhIP. (PubMed id 11774364)9 Leong-Morgenthaler P.M....Morgenthaler S. (2001)
    573. Molecular description of three macro-deletions and an Alu-Alu recombination-mediated duplication in the HPRT gene in four patients with Lesch-Nyhan disease. (PubMed id 11336982)9 Brooks E.M....O'Neill J.P. (2001)
    574. A novel parasite-derived suicide gene for cancer gene therapy with specificity for lung cancer cells. (PubMed id 11535170)9 Trudeau C....Batist G. (2001)
    575. Functional complementation of a genetic deficiency with human artificial chromosomes. (PubMed id 11452360)9 MejA-a J.E....Larin Z. (2001)
    576. Quantitative gene expression analysis in microdissected archival formalin-fixed and paraffin-embedded tumor tissue. (PubMed id 11159180)9 Specht K....HAPfler H. (2001)
    577. Toxicological, medical and industrial hygiene aspects of glutaraldehyde with particular reference to its biocidal use in cold sterilization procedures. (PubMed id 11288136)9 Ballantyne B. and Jordan S.L. (2001)
    578. Mutational spectrum induced by acetaldehyde in the HP RT gene of human T lymphocytes resembles that in the p53 gene of esophageal can cers. (PubMed id 11698345)9 Noori P. and Hou S.M. (2001)
    579. The presence of single nucleotide instability in human breast cancer cell lines. (PubMed id 11691786)9 Watanabe N....Ushijima T. (2001)
    580. Optimization of a versatile in vitro transcription as say for the expression of multiple start site TATA-less promoters. (PubMed id 11669633)9 Lin Y....Scotto K.W. (2001)
    581. Phase II and pharmacokinetic/pharmacodynamic trial of sequential topoisomerase I and II inhibition with topotecan and etoposide in advanced non-small-cell lung cancer. (PubMed id 11269740)9 Dowlati A....Berger N.A. (2001)
    582. Markers for carcinogenicity among butadiene-polymer workers in China. (PubMed id 11397406)9 Hayes R.B....Smith M.T. (2001)
    583. DMBA-induced toxic and mutagenic responses vary dramatically between NER-deficient Xpa, Xpc and Csb mice. (PubMed id 11408355)9 Wijnhoven S.W....Vrieling H. (2001)
    584. Association between genetic polymorphisms and biomarkers in styrene-exposed workers. (PubMed id 11535253)9 Vodicka P....Hemminki K. (2001)
    585. Comparison of three different in vitro mutation assays used for the investigation of cytochrome P450-mediated mutagenicity of nitro-polycyclic aromatic hydrocarbons. (PubMed id 10727902)9 Kappers W.A....Horbach G.J. (2000)
    586. Lesch-Nyhan disease and the basal ganglia. (PubMed id 10760551)9 Visser J.E....Jinnah H.A. (2000)
    587. Vanillin (3-methoxy-4-hydroxybenzaldehyde) inhibits mutation induced by hydrogen peroxide, N-methyl-N-nitrosoguanidine and mitomycin C but not (137)Cs gamma-radiation at the CD59 locus in human-hamster hybrid A(L) cells. (PubMed id 10792012)9 Gustafson D.L....Waldren C.A. (2000)
    588. Distinguishing potential sources of genotoxic exposure via HPRT mutations. (PubMed id 11130945)9 Molholt B. and Finette B.A. (2000)
    589. Identification of in vivo mutations in exon 5 of the human HPRT gene in a set of pooled T-cell mutants by constant denaturant capill ary electrophoresis (CDCE). (PubMed id 10894891)9 FAolt S....Lambert B. (2000)
    590. Cancer chemotherapy and somatic cell mutation. (PubMed id 11027962)9 Kubota M....Wakazono Y. (2000)
    591. 1,3-butadiene: cancer, mutations, and adducts. Part I I: Roles of two metabolites of 1,3-butadiene in mediating its in vivo genotoxic ity. (PubMed id 10925839)9 Recio L....Steen A.M. (2000)
    592. Cytosolic 5'-nucleotidase hyperactivity in erythrocytes of Lesch-Nyhan syndrome patients. (PubMed id 10884027)9 Pesi R....Tozzi M.G. (2000)
    593. Mutagenesis and carcinogenesis in nucleotide excision repair-deficient XPA knock out mice. (PubMed id 10838141)9 van Steeg H....Vijg J. (2000)
    594. Combined effects of gamma-radiation and ethylene oxid e in human diploid fibroblasts. (PubMed id 10719032)9 Kolman A. and Chovanec M. (2000)
    595. Region-specific DNA damage by AT-specific DNA-reactiv e drugs is predicted by drug binding specificity. (PubMed id 10933811)9 Woynarowski J.M....Arnett B. (2000)
    596. New mutations of the HPRT gene in Lesch-Nyhan syndrome. (PubMed id 11068166)9 Mak B.S....Lin H.Y. (2000)
    597. Predicted changes in pre-mRNA secondary structure vary in their association with exon skipping for mutations in exons 2, 4, and 8 of the Hprt gene and exon 51 of the fibrillin gene. (PubMed id 10729708)9 Tu M....Valentine C.R. (2000)
    598. Zidovudine-didanosine coexposure potentiates DNA incorporation of zidovudine and mutagenesis in human cells. (PubMed id 11058153)9 Meng Q....Walker V.E. (2000)
    599. Unusual substrate specificity of a chimeric hypoxanthine-guanine phosphoribosyltransferase containing segments from the Plasmodium falciparum and human enzymes. (PubMed id 10833458)9 Sujay Subbayya I.N....Balaram H. (2000)
    600. Mutagenicity and loss of heterozygosity at the APRT locus in human lymphoblastoid cells exposed to 3'-azido-3'-deoxythymidine. (PubMed id 10970446)9 Meng Q....Walker V.E. (2000)
    601. Construction of a cosmid library of DNA replicated early in the S phase of normal human fibroblasts. (PubMed id 10861848)9 Brylawski B.P....Kaufman D.G. (2000)
    602. Converting the guanine phosphoribosyltransferase from Giardia lamblia to a hypoxanthine-guanine phosphoribosyltransferase. (PubMed id 10976110)9 Munagala N....Wang C.C. (2000)
    603. Effect of TEI-6720, a xanthine oxidase inhibitor, on the nucleoside transport in the lung cancer cell line A549. (PubMed id 10629441)9 Yamamoto T....Hada T. (2000)
    604. Biological indicators of genotoxic risk and metabolic polymorphisms. (PubMed id 11018745)9 Pavanello S. and Clonfero E. (2000)
    605. An unexpected affected female patient in a classical Lesch-Nyhan family. (PubMed id 10767182)9 De Gregorio L....Chamoles N.A. (2000)
    606. Abnormalities in cellular adhesion of neuroblastoma and fibroblast models of Lesch Nyhan syndrome. (PubMed id 10854773)9 Stacey N.C....Connolly G.P. (2000)
    607. Somatic mutation of hPMS2 as a possible cause of sporadic human colon cancer with microsatellite instability. (PubMed id 10822375)9 Ma A.H....Sedwick W.D. (2000)
    608. X-linkage does not account for the absence of father-son similarity in plasma uric acid concentrations. (PubMed id 10797440)9 Reed D.R. and Price R.A. (2000)
    609. Biomarkers of exposure and effect as indicators of potential carcinogenic risk arising from in vivo metabolism of ethylene to ethylene oxide. (PubMed id 10964097)9 Walker V.E....Swenberg J.A. (2000)
    610. Stable correction of a genetic deficiency in human ce lls by an episome carrying a 115 kb genomic transgene. (PubMed id 11101814)9 Wade-Martins R....James M.R. (2000)
    611. A review of the genetic and related effects of 1,3-butadiene in rodents and humans. (PubMed id 11018742)9 Jackson M.A....Waters M.D. (2000)
    612. Requirement of wild-type p53 protein for maintenance of chromosomal integrity. (PubMed id 10972990)9 Honma M....Hayashi M. (2000)
    613. Phenotypic and genotypic characterization of commonly used human prostatic cell lines. (PubMed id 10792179)9 Mitchell S....Lalani E. (2000)
    614. Genotoxic markers among butadiene polymer workers in China. (PubMed id 10607734)9 Hayes R.B....Smith M.T. (2000)
    615. The spectrum of inherited mutations causing HPRT deficiency: 75 new cases and a review of 196 previously reported cases. (PubMed id 11018746)9 Jinnah H.A....O'Neill J.P. (2000)
    616. Semiquantitative reverse transcription-polymerase chain reaction to evaluate the expression patterns of genes involved in the oestrogen pathway. (PubMed id 10828836)9 Rey J.M....Brouillet J.P. (2000)
    617. Novel genetic mutations responsible for the HPRT defi ciency and the clinical phenotypes in Japanese. (PubMed id 11783502)9 Yamada Y....Ogasawara N. (2000)
    618. Lesch-Nyhan syndrome presenting as acute renal failure secondary to obstructive uropathy. (PubMed id 11113762)9 Ankem M....Barone J.G. (2000)
    619. The food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine activates S-phase checkpoint and apoptosis, and induces gene mutation in human lymphoblastoid TK6 cells. (PubMed id 10728688)9 Zhu H....Gooderham N.J. (2000)
    620. A new method for the selection of protein interactions in mammalian cells. (PubMed id 10839990)9 Rojo-Niersbach E....Lehming N. (2000)
    621. Rational design of selective submicromolar inhibitors of Tritrichomonas foetus hypoxanthine-guanine-xanthine phosphoribosyltransfera se. (PubMed id 10769124)9 Aronov A.M....Wang C.C. (2000)
    622. [Biomarkers of gentotoxic risk and metabolic polymorphism] (PubMed id 11189784)9 Pavanello S. and Clonfero E. (2000)
    623. Analysis of oxidative DNA damage and HPRT mutant frequencies in cancer patients before and after radiotherapy. (PubMed id 10636001)9 Zwingmann I.H....Kleinjans J.C. (1999)
    624. Complex hprt deletion events are recovered after exposure of human lymphoblastoid cells to high-LET carbon and neon ion beams. (PubMed id 10229922)9 Kagawa Y....Yatagai F. (1999)
    625. Evaluation of the potential health effects of the atmospheric reaction products of polycyclic aromatic hydrocarbons. (PubMed id 10319378)9 Grosovsky A.J....Atkinson R. (1999)
    626. Methylation-dependent gene silencing induced by interleukin 1beta via nitric oxide production. (PubMed id 10587350)9 Hmadcha A....Pintado E. (1999)
    627. Crystal structures of the Toxoplasma gondii hypoxanthine-guanine phosphoribosyltransferase-GMP and -IMP complexes: comparison of purine binding interactions with the XMP complex. (PubMed id 10545170)9 HAcroux A....Borhani D.W. (1999)
    628. Elevated frequencies of hypoxanthine phosphoribosyltr ansferase lymphocyte mutants are detected in Russian liquidators 6 to 10 years after exposure to radiation from the Chernobyl nuclear power plant accident. (PubMed id 10029687)9 Thomas C.B....Jones I.M. (1999)
    629. Hypoxanthine-guanine phosphoribosyltransferase deficiency and erythrocyte synthesis of pyridine coenzymes. (PubMed id 10403507)9 Micheli V....Pompucci G. (1999)
    630. Elevated HPRT mutation frequencies in aflatoxin-exposed residents of daxin, Qidong county, People's Republic of China. (PubMed id 10545423)9 Wang S.S....Swenberg J.A. (1999)
    631. Reduced purine 5'-nucleotidase activity in lymphocytes of patients with systemic lupus erythematosus: results of a pilot study. (PubMed id 10343529)9 Stolk J.N....Boerbooms A.M. (1999)
    632. Influence of smoking and donor age on the spectrum of in vivo mutation at the HPRT-locus in T lymphocytes of healthy adults. (PubMed id 10635998)9 Podlutsky A....Lambert B. (1999)
    633. Purine pathway enzymes in a cyst forming strain of Toxoplasma gondii. (PubMed id 10576552)9 Gherardi A....Peyron F. (1999)
    634. 6-thioguanine resistance in a human colon carcinoma cell line with unaltered levels of hypoxanthine guanine phosphoribosyltransferase activity. (PubMed id 10404070)9 Bemi V....Camici M. (1999)
    635. Influence of genetic polymorphisms of biotransformation enzymes on gene mutations, strand breaks of deoxyribonucleic acid, and micronuclei in mononuclear blood cells and urinary 8-hydroxydeoxyguanosine in potroom workers exposed to polyaromatic hydrocarbons. (PubMed id 10505661)9 Carstensen U....Hagmar L. (1999)
    636. Is breast cancer cluster influenced by environmental and occupational factors among hospital nurses in Hungary? (PubMed id 10393363)9 Tompa A....Jakab M.G. (1999)
    637. An evaluation of styrene genotoxicity using several biomarkers in a 3-year follow-up study of hand-lamination workers. (PubMed id 10575431)9 Vodicka P....Hemminki K. (1999)
    638. Detection of crosslinks with the comet assay in relat ionship to genotoxicity and cytotoxicity. (PubMed id 10217071)9 Merk O. and Speit G. (1999)
    639. [Statistical methods of radiation hybrid mapping: analysis of a small number of genes] (PubMed id 10368789)9 Svishcheva G.R. and Aksenovich T.I. (1999)
    640. The influence of chromosomal location on the expression of two transgenes in mice. (PubMed id 9873036)9 Hatada S....Maeda N. (1999)
    641. Nickel subsulfide is similar to potassium dichromate in protecting normal human fibroblasts from the mutagenic effects of benzo[a]pyrene diolepoxide. (PubMed id 10334623)9 Hamdan S....Reinhold D. (1999)
    642. Antimutagenic effects of centchroman--a contraceptive and a candidate drug for breast cancer in multiple mutational assays. (PubMed id 10567037)9 Giri A.K....Ray S. (1999)
    643. Molecular spectra of HPRT deletion mutations in circulating T-lymphocytes in Fanconi anemia patients. (PubMed id 10635999)9 Laquerbe A....Papadopoulo D. (1999)
    644. New approaches to understanding p53 gene tumor mutation spectra. (PubMed id 10635987)9 Hollstein M....Hainaut P. (1999)
    645. Spontaneous and chemically induced point mutations in HPRT cDNA of the metabolically competent human lymphoblastoid cell line, MCL-5. (PubMed id 10636005)9 Krause G....Scherer G. (1999)
    646. Identification of a new single nucleotide substitution on the hypoxanthine-guanine phosphoribosyltransferase gene (HPRT(Tsou) from a Taiwanese aboriginal family with severe gout. (PubMed id 10451080)9 Chang S.J....Ko Y.C. (1999)
    647. Evidence for oxidative metabolism in the genotoxicity of the atmospheric reaction product 2-nitronaphthalene in human lymphoblastoid cell lines. (PubMed id 10521697)9 Sasaki J.C....Grosovsky A.J. (1999)
    648. Investigation of mutant frequency at the HPRT locus and changes in microsatellite sequences in healthy young adults. (PubMed id 10635997)9 Davies M.J....Rumsby P.C. (1999)
    649. Different somatic and germline HPRT1 mutations promot e use of a common, cryptic intron 1 splice site. Mutations in brief no. 246. On line. (PubMed id 10408785)9 Colgin L.M....Monnat R.J. (1999)
    650. Clonality markers in polycythaemia and primary thrombocythaemia. (PubMed id 10640217)9 Briere J. and el-Kassar N. (1998)
    651. Molecular events after antisense inhibition of hMSH2 in a HeLa cell line. (PubMed id 9756996)9 Qian Y....Shen B. (1998)
    652. Oxidative DNA damage and cytogenetic effects in flight engineers exposed to cosmic radiation. (PubMed id 9776174)9 Zwingmann I.H....Kleinjans J.C. (1998)
    653. Regulation of the expression of enzymes involved in the replication of DNA in chemically induced monocytic/macrophagic differentiation of HL-60 leukemia cells. (PubMed id 9680096)9 Chen Y....Sartorelli A.C. (1998)
    654. Genetic effects of 1,3-butadiene and associated risk for heritable damage. (PubMed id 9463556)9 Pacchierotti F....Waters R. (1998)
    655. HGPRT and APRT activities in hemolysates during the first year of life. (PubMed id 9598047)9 BuA+o A....Mateos F.A. (1998)
    656. Peroxynitrite modulates MnSOD gene expression in lung epithelial cells. (PubMed id 9741582)9 Jackson R.M....Helton E.S. (1998)
    657. Factors contributing to discrepancies in population monitoring studies. (PubMed id 9685705)9 Au W.W....Salama S. (1998)
    658. DNA strand biases and the mutational resilience of genes. (PubMed id 9685587)9 Suri A....Glickman B. (1998)
    659. Significance of formaldehyde-induced DNA-protein cros slinks for mutagenesis. (PubMed id 9814441)9 Merk O. and Speit G. (1998)
    660. Specificity of mutations in the PMS2-deficient human tumor cell line HEC-1-A. (PubMed id 9838164)9 Kato T....Ikenaga M. (1998)
    661. p53, mutations, and apoptosis in genistein-exposed human lymphoblastoid cells. (PubMed id 9729267)9 Morris S.M....Casciano D.A. (1998)
    662. IMP-dehydrogenase (IMPDH), hypoxanthine-guanine phosp horibosyltransferase (HGPRT), and phosphodiesterases (PDEs) expression during m ycophenolic acid (MPA)-induced differentiation in human neuroblastoma cell line s. (PubMed id 9598106)9 Quaratino C.P....Giacomello A. (1998)
    663. A single amino acid substitution in the human and a bacterial hypoxanthine phosphoribosyltransferase modulates specificity for the binding of guanine. (PubMed id 9521670)9 Lee C.C....Eakin A.E. (1998)
    664. Carcinogen-induced loss of heterozygosity at the Aprt locus in somatic cells of the mouse. (PubMed id 9811874)9 Wijnhoven S.W....Vrieling H. (1998)
    665. Nicotinic acid supplementation: effects on niacin status, cytogenetic damage, and poly(ADP-ribosylation) in lymphocytes of smokers. (PubMed id 9919621)9 Hageman G.J....Kleinjans J.C. (1998)
    666. Genetically engineered cells stably expressing cytochrome P450 and their application to mutagen assays. (PubMed id 9675235)9 Sawada M. and Kamataki T. (1998)
    667. Human in vivo somatic mutation measured at two loci: individuals with stably elevated background erythrocyte glycophorin A (gpa) variant frequencies exhibit normal T-lymphocyte hprt mutant frequencies. (PubMed id 9541637)9 Bigbee W.L....Moore M.M. (1998)
    668. A human lymphoid leukemia cell line with a V(D)J reco mbinase-mediated deletion of hprt. (PubMed id 9726012)9 Chen C.L....Relling M.V. (1998)
    669. Craniocerebral magnetic resonance imaging measurement and findings in Lesch-Nyhan syndrome. (PubMed id 9561984)9 Harris J.C....Bryan R.N. (1998)
    670. Carrier state in HGPRT deficiency. A study in 14 Spanish families. (PubMed id 9598058)9 Torres R.J....Puig J.G. (1998)
    671. Mutagenicity of 2-amino-3-methylimidazo[4,5-f]quinoline in human lymphoblastoid cells. (PubMed id 9806154)9 Leong-Morgenthaler P.M....Turesky R.J. (1998)
    672. DNA hypomethylation leads to elevated mutation rates. (PubMed id 9738504)9 Chen R.Z....Jaenisch R. (1998)
    673. Impaired differentiation of HPRT-deficient dopaminergic neurons: a possible mechanism underlying neuronal dysfunction in Lesch-Nyhan syndrome. (PubMed id 9670994)9 Yeh J....Howard B.D. (1998)
    674. Complementation of mismatch repair gene defects by chromosome transfer. (PubMed id 9675233)9 Tindall K.R....Kunkel T.A. (1998)
    675. Cellular resistance and hypermutability in mismatch repair-deficient human cancer cell lines following treatment with methyl methanesulfonate. (PubMed id 9626980)9 Glaab W.E....Tindall K.R. (1998)
    676. Analysis of the DNA damage induced by praziquantel in V-79 Chinese hamster fibroblasts and human blood cells using the single-cell g el electrophoresis assay. (PubMed id 9586770)9 Herrera L.A....Rojas del Castillo E. (1998)
    677. Radiation-induced long-lived radicals which cause mut ation and transformation. (PubMed id 9748497)9 Koyama S....Watanabe M. (1998)
    678. Targeted gene knockout mediated by triple helix forming oligonucleotides. (PubMed id 9771719)9 Majumdar A....Seidman M.M. (1998)
    679. Biomarkers in long survivors of pediatric acute lymphoblastic leukemia patients: late effects of cancer chemotherapy. (PubMed id 9838123)9 Koishi S....Furusho K. (1998)
    680. Role of cysteine and lysine residues in human hypoxan thine-guanine phosphoribosyltransferase. (PubMed id 9598086)9 Keough D.T....de Jersey J. (1998)
    681. Approaching the transition state in the crystal structure of a phosphoribosyltransferase. (PubMed id 9860824)9 Focia P.J....Eakin A.E. (1998)
    682. The frequency of illegitimate V(D)J recombinase-mediated mutations in children treated with etoposide-containing antileukemic therapy. (PubMed id 9804912)9 Fuscoe J.C....Relling M.V. (1998)
    683. How should we treat tophaceous gout in patients with allopurinol hypersensitivity? (PubMed id 9598024)9 Grahame R....Marsh F.P. (1998)
    684. Comparative mapping of X chromosomes in vole species of the genus Microtus. (PubMed id 9510509)9 Nesterova T.B....Brockdorff N. (1998)
    685. Sequence- and region-specificity of oxaliplatin adduc ts in naked and cellular DNA. (PubMed id 9804612)9 Woynarowski J.M....Juniewicz P. (1998)
    686. Genetic analysis of PHIP intestinal mutations in MutaMouse. (PubMed id 9862191)9 Lynch A.M....Boobis A.R. (1998)
    687. Partial deficiency of hypoxanthine-guanine phosphoribosyltransferase manifesting as acute renal damage. (PubMed id 9868957)9 Hikita M....Sakuma R. (1998)
    688. Measurement of mutation frequency at the HPRT locus in peripheral lymphocytes. Is this a good method to evaluate a cancer risk in pediatric patients? (PubMed id 9598152)9 Lin Y.W....Furusho K. (1998)
    689. Targeted breakage of paracentromeric heterochromatin induces chromosomal instability. (PubMed id 9800188)9 Smith L.E....Grosovsky A.J. (1998)
    690. Regulation of the expression of enzymes involved in the replication of DNA in chemically-induced granulocytic differentiation of HL-60 leukemia cells. (PubMed id 9680095)9 Chen Y....Sartorelli A.C. (1998)
    691. Detoxification of optically active bay- and fjord-region polycyclic aromatic hydrocarbon dihydrodiol epoxides by human glutathione transferase P1-1 expressed in Chinese hamster V79 cells. (PubMed id 9855012)9 Seidel A....Glatt H. (1998)
    692. Prospective study of mutant frequencies at the hprt and T-cell receptor gene loci in pediatric cancer patients during chemotherapy. (PubMed id 9718224)9 Sawada M....Furusho K. (1998)
    693. Mutagenicity of vinyl chloride and its reactive metabolites, chloroethylene oxide and chloroacetaldehyde, in a metabolically competent human B-lymphoblastoid line. (PubMed id 9054586)9 Chiang S.Y....Skopek T.R. (1997)
    694. Hypoxanthine phosphoribosyltransferase from Trypanoso ma cruzi as a target for structure-based inhibitor design: crystallization and inhibition studies with purine analogs. (PubMed id 9257742)9 Eakin A.E....Craig S.P. (1997)
    695. Reversal of methylation tolerance by transfer of human chromosome 2. (PubMed id 9447233)9 Aquilina G....Bignami M. (1997)
    696. [Ecopathology of the kidneys and individual sensitivity to heavy metal salts] (PubMed id 9297273)9 Ignatova M.S....Raba G.P. (1997)
    697. Genotoxicity induced in human lymphoblasts by atmospheric reaction products of naphthalene and phenanthrene. (PubMed id 9357559)9 Sasaki J.C....Grosovsky A.J. (1997)
    698. Ectopically expressed CAG repeats cause intranuclear inclusions and a progressive late onset neurological phenotype in the mouse. (PubMed id 9413985)9 Ordway J.M....Detloff P.J. (1997)
    699. Characterization of hprt mutations following 1,2-epoxy-3-butene exposure of human TK6 cells. (PubMed id 9379915)9 Steen A.M....Recio L. (1997)
    700. Expression of SV40 large T antigen stimulates reversi on of a chromosomal gene duplication in human cells. (PubMed id 9260898)9 Cheng R.Z....Shmookler Reis R.J. (1997)
    701. Substitution of lysine for arginine at position 199 of a hypoxanthine phosphoribosyltransferase interferes with binding of the primary substrate to the active site. (PubMed id 9165092)9 Craig S.P....Fletterick R.J. (1997)
    702. Molecular characterization of mutations in the hprt g ene of normal human skin keratinocytes treated with N-ethyl-N-nitrosourea: infl uence of O6-alkylguanine alkyltransferase. (PubMed id 9118969)9 Tong H.H....D'Ambrosio S.M. (1997)
    703. Molecular analysis of mutations in T-lymphocytes from experienced Soviet cosmonauts. (PubMed id 9258326)9 Khaidakov M....Glickman B.W. (1997)
    704. Nitrogen mustard-mediated mutagenesis in human T-lymp hocytes in vitro. (PubMed id 9049058)9 Olsen L.S....Wassermann K. (1997)
    705. A new T-lymphocyte cloning assay for detection of in vivo mutations in the human hypoxanthine-guanine phosphoribosyltransferase gene. (PubMed id 9258327)9 Uematsu K....Sekiya T. (1997)
    706. Assessing human risk to heterocyclic amines. (PubMed id 9202738)9 Gooderham N.J....Davies D.S. (1997)
    707. Mismatch repair defects and O6-methylguanine-DNA methyltransferase expression in acquired resistance to methylating agents in human cells. (PubMed id 9353325)9 Hampson R....Karran P. (1997)
    708. Carcinogens stimulate intrachromosomal homologous rec ombination at an endogenous locus in human diploid fibroblasts. (PubMed id 9506887)9 Li J....Shmookler Reis R.J. (1997)
    709. Clonality in hematopoietic disorders. (PubMed id 9479867)9 Hotta T. (1997)
    710. 3-Chloro-p-toluidine hydrochloride: in vitro mutagenicity studies for human health hazards determinations. (PubMed id 9140464)9 Stankowski L.F....Sterner R.T. (1997)
    711. Quantification of hprt gene deletions mediated by illegitimate V(D)J recombination in peripheral blood cells of humans. (PubMed id 9020304)9 Fuscoe J.C....Moore M.M. (1997)
    712. Increased genetic stability of HeLa cells after connexin 43 gene transfection. (PubMed id 9187113)9 Zhu W....Yamasaki H. (1997)
    713. Inactivation of Tritrichomonas foetus and Schistosoma mansoni purine phosphoribosyltransferases by arginine-specific reagents. (PubMed id 9108251)9 Kanaani J....Wang C.C. (1997)
    714. Influence of donor age on the cytotoxicity and mutage nicity of ethylnitrosourea in cultured human T-lymphocytes. (PubMed id 9194214)9 Mei N....Norimura T. (1997)
    715. Replication timing properties of the human HPRT locus on active, inactive and reactivated X chromosomes. (PubMed id 9330638)9 Subramanian P.S. and Chinault A.C. (1997)
    716. Study of Alu sequences at the hypoxanthine phosphorib osyltransferase (hprt) encoding region of man. (PubMed id 9031622)9 Renwick P.J....HultAcn M.A. (1997)
    717. Spectra of X-ray-induced and spontaneous intragenic HPRT mutations in closely related human cells differentially expressing the p53 tumor suppressor gene. (PubMed id 9008205)9 Phillips E.N....Liber H.L. (1997)
    718. In vivo antioxidant status, DNA damage, mutation and DNA repair capacity in cultured lymphocytes from healthy 75- to 80-year-old humans. (PubMed id 9219588)9 King C.M....Barnett Y.A. (1997)
    719. Spectra of spontaneous mutations at the hprt locus in colorectal carcinoma cell lines defective in mismatch repair. (PubMed id 9214593)9 Ohzeki S....Kato T. (1997)
    720. Comparisons of the frequencies and molecular spectra of HPRT mutants when human cancer cells were X-irradiated during G1 or S phase. (PubMed id 9399700)9 Leonhardt E.A....Dewey W.C. (1997)
    721. Loss of heterozygosity at chromosome segment Xq25-26.1 in advanced human ovarian carcinomas. (PubMed id 9365830)9 Choi C....Koi M. (1997)
    722. 5-Azadeoxycytidine-induced chromatin remodeling of th e inactive X-linked HPRT gene promoter occurs prior to transcription factor bin ding and gene reactivation. (PubMed id 9169463)9 Litt M.D....Yang T.P. (1997)
    723. Mutagenicity and cytotoxicity of reactive oxygen and nitrogen species in the MN-11 murine tumor cell line. (PubMed id 9357553)9 Sandhu J.K. and Birnboim H.C. (1997)
    724. Role of nitroreductases but not cytochromes P450 in the metabolic activation of 1-nitropyrene in the HepG2 human hepatoblastoma cell line. (PubMed id 9354593)9 Silvers K.J....Howard P.C. (1997)
    725. Mutation frequency and spectrum in lymphocytes of sma ll cell lung cancer patients receiving etoposide chemotherapy. (PubMed id 9331103)9 Karnaoukhova L....Glickman B. (1997)
    726. Correlated mutagenesis of bcl2 and hprt loci in blood lymphocytes. (PubMed id 9020305)9 Liu Y....Cole J. (1997)
    727. Kinetic mechanism of human hypoxanthine-guanine phosp horibosyltransferase: rapid phosphoribosyl transfer chemistry. (PubMed id 9132023)9 Xu Y....Grubmeyer C. (1997)
    728. [Metabolism of purine nucleotides and the production of uric acid] (PubMed id 8976090)9 Yamaoka T. and Itakura M. (1996)
    729. Intercorrelations and sources of variability in three mutagenicity assays: a population-based study. (PubMed id 8600359)9 Radack K....Mandell K. (1996)
    730. Biological effect monitoring in industrial workers from the Czech Republic exposed to low levels of butadiene. (PubMed id 8901887)9 Tates A.D....SrA!m R.J. (1996)
    731. Novel nonsense mutation in the hypoxanthine guanine phosphoribosyltransferase gene and nonrandom X-inactivation causing Lesch-Nyhan syndrome in a female patient. (PubMed id 8664901)9 Aral B....Ceballos-Picot I. (1996)
    732. Large deletions at the HPRT locus associated with the mutator phenotype in a Bloom's syndrome lymphoblastoid cell line. (PubMed id 8876674)9 Tachibana A....Kato T. (1996)
    733. hprt mutation frequency among workers exposed to 1,3-butadiene in China. (PubMed id 8901888)9 Hayes R.B....O'Neill J.P. (1996)
    734. Quantification of X-chromosome inactivation patterns in haematological samples using the DNA PCR-based HUMARA assay. (PubMed id 8637249)9 Gale R.E....Linch D.C. (1996)
    735. Mutational spectra of the dietary carcinogen 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine(PhIP) at the Chinese hamsters hprt locus. (PubMed id 8625468)9 Yadollahi-Farsani M....Boobis A.R. (1996)
    736. [Gene therapy for genetic disorders of purine metabolism] (PubMed id 8976123)9 Hidaka Y. (1996)
    737. Dependence of mutation induction on fast-neutron energy in a human epithelial teratocarcinoma cell line (P3). (PubMed id 8927701)9 Sharma S. and Hill C.K. (1996)
    738. The majority of T lymphocytes are polyclonal during the chronic phase of chronic myelogenous leukemia. (PubMed id 8597608)9 Tsukamoto N....Omine M. (1996)
    739. Effects of cell cycle position on ionizing radiation mutagenesis. I. Quantitative assays of two genetic loci in a human lymphoblastoid cell line. (PubMed id 8896575)9 Chuang Y.Y. and Liber H.L. (1996)
    740. Genetic, cytogenetic, and carcinogenic effects of radon: a review. (PubMed id 8692177)9 Jostes R.F. (1996)
    741. Heterocyclic amines: evaluation of their role in diet associated human cancer. (PubMed id 8807149)9 Gooderham N.J....Davies D.S. (1996)
    742. Individual variation and age dependency in the radios ensitivity of peripheral blood T-lymphocytes from normal donors. (PubMed id 9090198)9 Mei N....Norimura T. (1996)
    743. Increased hprt mutant frequencies in Brazilian children accidentally exposed to ionizing radiation. (PubMed id 8908186)9 Saddi V....Glickman B.W. (1996)
    744. Germinal HPRT splice donor site mutation results in multiple RNA splicing products in T-lymphocyte cultures. (PubMed id 8782493)9 Hunter T.C....O'Neill J.P. (1996)
    745. Thymidine kinase deficient cells with decreased TTP pools are hypersensitive to DNA alkylating agents. (PubMed id 8538643)9 Wakazono Y....Gerson S.L. (1996)
    746. Comparison of the rate of excision of major UV photop roducts in the strands of the human HPRT gene of normal and xeroderma pigmentos um variant cells. (PubMed id 8538650)9 Tung B.S....McCormick J.J. (1996)
    747. Evidence against chronic antigen-specific T lymphocyte activation in myasthenia gravis. (PubMed id 8872911)9 Infante A.J....Krolick K.A. (1996)
    748. A role for apoptosis in the toxicity and mutagenicity of bleomycin in AHH-1 tk+/- human lymphoblastoid cells. (PubMed id 8876690)9 Morris S.M....Casciano D.A. (1996)
    749. Prenatal diagnosis by enzyme analysis in 15 pregnanci es at risk for the Lesch-Nyhan syndrome. (PubMed id 8843475)9 Graham G.W....Connor J.M. (1996)
    750. Role of late replication timing in the silencing of X-linked genes. (PubMed id 8872476)9 Hansen R.S....Gartler S.M. (1996)
    751. Increased frequency of specific genomic deletions res ulting from in vitro malathion exposure. (PubMed id 8625317)9 Pluth J.M....Albertini R.J. (1996)
    752. Two distinct apolipoprotein B alleles in mice generat ed by a single 'in-out' targeting. (PubMed id 8921909)9 Toth L.R....Maeda N. (1996)
    753. The presence of a pseudogene may affect the use of HP RT as an endogenous mRNA control in RT-PCR. (PubMed id 9025089)9 Sellner L.N. and Turbett G.R. (1996)
    754. Inverse dose-rate effect for mutation induction by gamma-rays in human lymphoblasts. (PubMed id 8648243)9 Amundson S.A. and Chen D.J. (1996)
    755. Generation of a panel of radiation-reduced hybrids containing human 11q22-23 fragments bearing a HPRT selective marker: identification of hybrids carrying various subregions around the ataxia-telangiectasia locus. (PubMed id 9131019)9 Ejima Y....Sasaki M.S. (1996)
    756. Etoposide causes illegitimate V(D)J recombination in human lymphoid leukemic cells. (PubMed id 8822941)9 Chen C.L....Relling M.V. (1996)
    757. Characterization of multilocus lesions in human cells exposed to X radiation and radon. (PubMed id 8532834)9 Chaudhry M.A....Evans H.H. (1996)
    758. Purine deoxynucleoside metabolism in human melanoma cells with a high spontaneous mutation rate. (PubMed id 8657185)9 Musk P....Parsons P.G. (1996)
    759. Loss of DNA mismatch repair in acquired resistance to cisplatin. (PubMed id 8674066)9 Aebi S....Howell S.B. (1996)
    760. Future research directions to characterize environmental mutagens in highly polluted area. (PubMed id 8781390)9 SrA!m R.J. (1996)
    761. Hypoxanthine-guanine phosphoribosyltransferase gene analysis for Japanese patients with Lesch-Nyhan syndrome. (PubMed id 8992857)9 Shimizu N....Aoki T. (1996)
    762. Mutagenicity study of the new cephalosporin antibiotic cefditoren pivoxil. (PubMed id 9125285)9 Shindo Y....Tatebayashi T. (1996)
    763. [Inherited disorders of uric acid metabolism--classification, enzymatic- and DNA-diagnosis] (PubMed id 8976110)9 Iwahana H. and Itakura M. (1996)
    764. Effect of nuclear environment on the distribution of benzo[a]pyrene diol epoxide-induced adducts in the HPRT gene of human fibroblas ts. (PubMed id 9006108)9 Wei D....McCormick J.J. (1996)
    765. Mice with adenine phosphoribosyltransferase deficiency develop fatal 2,8-dihydroxyadenine lithiasis. (PubMed id 8864750)9 Redhead N.J....Melton D.W. (1996)
    766. [Hypoxanthine guanine phosphoribosyl transferase] (PubMed id 8976093)9 Ogasawara N. (1996)
    767. Relationship between cytotoxicity and site-specific D NA recombination after in vitro exposure of leukemia cells to etoposide. (PubMed id 8961974)9 Chen C.L....Relling M.V. (1996)
    768. Site-specific excision repair of 1-nitrosopyrene-induced DNA adducts at the nucleotide level in the HPRT gene of human fibroblasts: effect of adduct conformation on the pattern of site-specific repair. (PubMed id 8668188)9 Wei D....McCormick J.J. (1996)
    769. Differences in the spectrum of spontaneous mutations in the hprt gene between tumor cells of the microsatellite mutator phenotype. (PubMed id 8649458)9 Malkhosyan S....Perucho M. (1996)
    770. [Complete and partial deficiency of HPRT] (PubMed id 8976112)9 Ogasawara N. (1996)
    771. Purine enzyme activities in recent onset rheumatoid arthritis: are there differences between patients and healthy controls? (PubMed id 8984938)9 Stolk J.N....van de Putte L.B. (1996)
    772. DNA adducts: biological markers of exposure and potential applications to risk assessment. (PubMed id 8898994)9 La D.K. and Swenberg J.A. (1996)
    773. [Abnormalities in urate metabolism: concept and classification] (PubMed id 8976099)9 Akaoka I. and Kamatani N. (1996)
    774. Comparison of the frequency of T-cell receptor mutant s and thioguanine resistance induced by X-rays and ethylnitrosourea in cultured human blood T-lymphocytes. (PubMed id 8876694)9 Mei N....Norimura T. (1996)
    775. Biomonitoring human exposure to environmental carcinogenic chemicals. (PubMed id 8671761)9 Farmer P.B....Castelain P. (1996)
    776. Quantitative and qualitative effect of gamma-ray dose -rate on mutagenesis in human lymphoblastoid cells. (PubMed id 8794850)9 Furuno-Fukushi I....Tachibana A. (1996)
    777. In vivo footprinting and high-resolution methylation analysis of the mouse hypoxanthine phosphoribosyltransferase gene 5' region on the active and inactive X chromosomes. (PubMed id 8887649)9 Litt M.D....Yang T.P. (1996)
    778. Somatic mutations are frequent and increase with age in human kidney epithelial cells. (PubMed id 8824877)9 Martin G.M....Monnat R.J. (1996)
    779. [Mutation induction by heavy ion beams and X-rays: an alysis with cultured cell line] (PubMed id 8914407)9 Toya K....Kanai T. (1996)
    780. Thermal stability of Artemia HGPRT: effect of substrates on inactivation kinetics. (PubMed id 8739129)9 Montero C....Menendez M. (1996)
    781. Mutational spectra vary with exposure conditions: ben zo[a]pyrene in human cells. (PubMed id 8876696)9 Chen J. and Thilly W.G. (1996)
    782. Isolation and characterization of HPRT-deficient human hepatoma cells. (PubMed id 9000176)9 Porter M.B. and Fournier R.E. (1996)
    783. GTP gamma S restores nucleophosmin (NPM) localization to nucleoli of GTP-depleted HeLa cells. (PubMed id 7565647)9 Finch R.A....Chan P.K. (1995)
    784. The influence of smoking and diet on the hypoxanthine phosphoribosyltransferase (hprt) mutant frequency in circulating T lymphocytes from a normal human population. (PubMed id 7666869)9 Duthie S.J....Collins A.R. (1995)
    785. Gene therapy and the brain. (PubMed id 7767640)9 Jinnah H.A. and Friedmann T. (1995)
    786. DNA sequence analysis of spontaneous hprt mutations a rising in vivo in cynomolgus monkey T-lymphocytes. (PubMed id 7588647)9 Harbach P.R....Aaron C.S. (1995)
    787. Effect of dietary components on hprt mutant frequenci es in human T-lymphocytes. (PubMed id 7700275)9 Branda R.F. and Albertini R.J. (1995)
    788. Southern analysis reveals a large deletion at the hypoxanthine phosphoribosyltransferase locus in a patient with Lesch-Nyhan syndrome. (PubMed id 7586656)9 Renwick P.J....HultAcn M. (1995)
    789. Characterization of in vivo mutated T cell clones from patients with systemic lupus erythematosus. (PubMed id 7828367)9 Theocharis S....Tsokos G.C. (1995)
    790. Lesch-Nyhan syndrome and its pathogenesis: normal nic otinamide-adenine dinucleotide but reduced ATP concentrations that correlate wi th reduced poly(ADP-ribose) synthetase activity in HPRT-deficient lymphoblasts. (PubMed id 8750613)9 McCreanor G.M. and Harkness R.A. (1995)
    791. Hypoxanthine-guanine phosphoribosyltransferase as a therapeutic target in protozoal infections. (PubMed id 7728354)9 Ullman B. and Carter D. (1995)
    792. Frequency of HPRT mutant lymphocytes in a human contr ol population as determined by the T-cell cloning procedure. (PubMed id 7477056)9 HA1ttner E....Kropf S. (1995)
    793. Molecular analysis of mutations in mutator colorectal carcinoma cell lines. (PubMed id 8589681)9 Bhattacharyya N.P....Meuth M. (1995)
    794. Extensive loss of heterozygosity accounts for differential mutation rate on chromosome 17q in human lymphoblasts. (PubMed id 7739402)9 Dobo K.L....Grosovsky A.J. (1995)
    795. Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer. (PubMed id 7824277)9 Eshleman J.R....Markowitz S.D. (1995)
    796. The use of L5178Y mouse lymphoma cells to assess the mutagenic, clastogenic and aneugenic properties of chemicals. (PubMed id 8544753)9 Combes R.D....Caspary W.J. (1995)
    797. Analysis of mutation at the hprt locus in human T lymphocytes. (PubMed id 8597072)9 Lambert B....Hou S.M. (1995)
    798. Recombinagenic activity of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate in human lymphoblastoid cells. (PubMed id 7634395)9 Honma M. and Little J.B. (1995)
    799. Modulation of bleomycin-induced mitotic recombination in yeast by the aminothiols cysteamine and WR-1065. (PubMed id 8552041)9 Hoffmann G.R....Littlefield L.G. (1995)
    800. Suggestions concerning the relationship between mutan t frequency and mutation rate at the hprt locus in human peripheral T-lymphocyt es. (PubMed id 7753096)9 Green M.H....Cole J. (1995)
    801. Sensitivity of somatic mutations in human umbilical cord blood to maternal environments. (PubMed id 7588645)9 Manchester D.K....Bigbee W.L. (1995)
    802. Impact of age and environment on somatic mutation at the hprt gene of T lymphocytes in humans. (PubMed id 7565868)9 Jones I.M....Moore D.H. (1995)
    803. 1,3-Butadiene working group report. (PubMed id 7623862)9 Adler I.D....Vogel E. (1995)
    804. Biomarkers of styrene exposure in lamination workers: levels of O6-guanine DNA adducts, DNA strand breaks and mutant frequencies in the hypoxanthine guanine phosphoribosyltransferase gene in T-lymphocytes. (PubMed id 7614680)9 Vodicka P....Hemminki K. (1995)
    805. Nitric oxide and ethylnitrosourea: relative mutagenicity in the p53 tumor suppressor and hypoxanthine-phosphoribosyltransferase genes. (PubMed id 7554056)9 Felley-Bosco E....Harris C.C. (1995)
    806. Hprt mutant frequency and GSTM1 genotype in non-smoking healthy individuals. (PubMed id 7698112)9 Hou S.M....Steen A.M. (1995)
    807. Purine enzyme activities in peripheral blood mononuclear cells: comparison of a new non-radiochemical high-performance liquid chromatography procedure and a radiochemical thin-layer chromatography procedure. (PubMed id 7655619)9 Stolk J.N....van de Putte L.B. (1995)
    808. U.v.-hypermutability of xeroderma pigmentosum cells demonstrated with a DNA-based mutation system. (PubMed id 7761106)9 Steingrimsdottir H....Lehmann A.R. (1995)
    809. Kinetics of adenylate metabolism in human and rat myocardium. (PubMed id 7599155)9 Tavenier M....de Jong J.W. (1995)
    810. Thiol and disulfide metabolites of the radiation prot ector and potential chemopreventive agent WR-2721 are linked to both its anti-c ytotoxic and anti-mutagenic mechanisms of action. (PubMed id 7728953)9 Grdina D.J....Fahey R.C. (1995)
    811. Correlation of gene-specific damage with cisplatin be tween human adenocarcinoma cells and peripheral blood mononuclear cells analyze d by polymerase chain reaction-stop assay. (PubMed id 7730149)9 Oshita F....Saijo N. (1995)
    812. Somatic cell mutation frequency at the HPRT, T-cell antigen receptor and glycophorin A loci in Cockayne syndrome. (PubMed id 7596357)9 Lin Y.W....Ohta S. (1995)
    813. Epidemiological and mechanistic data suggest that 1,3-butadiene will not be carcinogenic to humans at exposures likely to be encountered in the environment or workplace. (PubMed id 7859344)9 Bond J.A....Andjelkovich D. (1995)
    814. Occupational exposure to nor-nitrogen mustard: chemical and biological monitoring. (PubMed id 7652754)9 Thulin H....Hartley-Asp B. (1995)
    815. Analysis of the structural integrity of YACs comprisi ng human immunoglobulin genes in yeast and in embryonic stem cells. (PubMed id 7601456)9 Mendez M.J....Garza D. (1995)
    816. Molecular analysis of mutations in the hprt gene of V79 hamster fibroblasts: effects of imbalances in the dCTP, dGTP and dTTP pools. (PubMed id 7563070)9 DarA" E....Bianchi V. (1995)
    817. Clonality studies in patients undergoing allogeneic and autologous bone marrow transplantation for haematological malignancies. (PubMed id 7742760)9 Saunders M.J....Yin J.A. (1995)
    818. Programmed cell death and mutation induction in AHH-1 human lymphoblastoid cells exposed to m-amsa. (PubMed id 7770078)9 Morris S.M....Casciano D.A. (1995)
    819. Mutant frequency at the hprt locus in human lymphocytes in a case-control study of lung cancer. (PubMed id 7500985)9 Cheng T.J....Kelsey K.T. (1995)
    820. Lack of correlation between degree of interference with transcription and rate of strand specific repair in the HPRT gene of diploid human fibroblasts. (PubMed id 7592980)9 McGregor W.G....McCormick J.J. (1995)
    821. Cysteine conjugate beta-lyase activity in human renal carcinomas. (PubMed id 7767899)9 Nelson J.A....Elfarra A.A. (1995)
    822. Do persons living near a uranium processing site have evidence of increased somatic cell gene mutations? A first study. (PubMed id 7477048)9 Wones R....Buncher R. (1995)
    823. [Analysis of the allelic polymorphism of four short tandem repeats in a population from the northwestern region of Russia] (PubMed id 7635321)9 Assev M.V....Baranov V.S. (1995)
    824. Mutagenicity and specific mutation spectrum induced b y 8-methoxypsoralen plus a low dose of UVA in the hprt gene in diploid human fi broblasts. (PubMed id 7788855)9 Chiou C.C. and Yang J.L. (1995)
    825. [Opposite effect of p53 on nucleotide metabolizing enzyme activity in Rat1 cells and their sublines, transformed by N-RAS or v-mos oncogenes] (PubMed id 8590759)9 Khramtsova S.N....Kopnin B.P. (1995)
    826. Styrene oxide-induced HPRT mutations, DNA adducts and DNA strand breaks in cultured human lymphocytes. (PubMed id 7586135)9 BastlovA! T....Lambert B. (1995)
    827. A radiation hybrid map of human chromosome 18. (PubMed id 8125019)9 Francke U....Wilgenbus P. (1994)
    828. Clonal analysis of human adrenocortical carcinomas and secreting adenomas. (PubMed id 7910530)9 Gicquel C....Le Bouc Y. (1994)
    829. Relationship between the levels of purine salvage pathway enzymes and clinical/biological aggressiveness of human colon carcinoma. (PubMed id 7796389)9 Sanfilippo O....Silvestrini R. (1994)
    830. Uric acid nephrolithiasis. (PubMed id 7783706)9 Halabe A. and Sperling O. (1994)
    831. Role of differentiation induction in action of purine antimetabolites. (PubMed id 8032345)9 Weber G....Prajda N. (1994)
    832. The distal region of the long arm of human chromosome 1 carries tumor suppressor activity for a human fibrosarcoma line. (PubMed id 8174085)9 Klein K.G. and Bouck N.P. (1994)
    833. Frequencies of HPRT mutants and micronuclei in lymphocytes of cancer patients under chemotherapy: a prospective study. (PubMed id 7513809)9 Tates A.D....Osanto S. (1994)
    834. Altered pyridine metabolism in the erythrocytes of a mentally retarded infant with partial HPRT deficiency. (PubMed id 7660925)9 Micheli V....Pompucci G. (1994)
    835. Clinical symptoms of patients with partial HPRT deficiency. (PubMed id 7660923)9 Gathof B.S....Gresser U. (1994)
    836. Detection of opiate-enhanced increases in DNA damage, HPRT mutants, and the mutation frequency in human HUT-78 cells. (PubMed id 8125082)9 Shafer D.A....Falek A. (1994)
    837. Assessment of clinical parameters associated with inc reased frequency of mutant T cells in patients with systemic lupus erythematosu s. (PubMed id 8129782)9 Dawisha S.M....Steinberg A.D. (1994)
    838. In vitro mutational spectrum of aflatoxin B1 in the h uman hypoxanthine guanine phosphoribosyltransferase gene. (PubMed id 8044792)9 Cariello N.F....Skopek T.R. (1994)
    839. Stable expression of human CYP1A2 and N-acetyltransferases in Chinese hamster CHL cells: mutagenic activation of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline. (PubMed id 8012961)9 Yanagawa Y....Kamataki T. (1994)
    840. Characteristics of HPRT-mutant T cell lines in a lupu s patient treated with cyclophosphamide. (PubMed id 7945481)9 Wood G.M....Gourley M. (1994)
    841. Measurement of frequencies of HPRT mutants, chromosomal aberrations, micronuclei, sister-chromatid exchanges and cells with high frequencies of SCEs in styrene/dichloromethane-exposed workers. (PubMed id 7523909)9 Tates A.D....Natarajan A.T. (1994)
    842. Activation of the Maillard reaction product 5-(hydroxymethyl)furfural to strong mutagens via allylic sulfonation and chlorination. (PubMed id 8075362)9 Surh Y.J. and Tannenbaum S.R. (1994)
    843. A 13 base pair deletion in exon 1 of HPRTIllinois forms a functional GUG initiation codon. (PubMed id 8125482)9 Davidson B.L....Roessler B.J. (1994)
    844. Mutation induction in human lymphoid cells by energetic heavy ions. (PubMed id 11538026)9 Kronenberg A. (1994)
    845. Mutation specificity of 8-methoxypsoralen plus two do ses of UVA irradiation in the hprt gene in diploid human fibroblasts. (PubMed id 8313509)9 Yang S.C....Yang J.L. (1994)
    846. Sequence, expression and characterization of HPRTMoose Jaw: a point mutation resulting in cooperativity and decreased substrate affinities. (PubMed id 7987318)9 Lightfoot T....Snyder F.F. (1994)
    847. Mutational spectrum of ICR-191 at the hprt locus in human lymphoblastoid cells. (PubMed id 8143707)9 Taft S.A....Skopek T.R. (1994)
    848. Mutator phenotypes in human colorectal carcinoma cell lines. (PubMed id 8022779)9 Bhattacharyya N.P....Meuth M. (1994)
    849. Lesch-Nyhan syndrome: successful prevention of lower lip ulceration caused by self-mutilation by use of mouth guard. (PubMed id 8163858)9 Sugahara T....Mori Y. (1994)
    850. Deletion mutations in the hprt gene of T-lymphocytes as a biomarker for genomic rearrangements important in human cancers. (PubMed id 8033326)9 Fuscoe J.C....Moore M.M. (1994)
    851. Cloning efficiency and spontaneous mutant frequency in circulating T-lymphocytes in ataxia-telangiectasia patients. (PubMed id 7836839)9 Cole J. and Arlett C.F. (1994)
    852. Clonality in chronic myeloproliferative disorders defined by X-chromosome linked probes: demonstration of heterogeneity in lineage involvement. (PubMed id 7911034)9 Tsukamoto N....Omine M. (1994)
    853. Effects of thymidine kinase and methyltransferase def iciency on mutagenesis in a human lymphoblastoid cell line. (PubMed id 7520981)9 Best C.J....McKenna P.G. (1994)
    854. [Synergistic cytotoxic effects of chemotherapy in colon tumor cells by simultaneous inhibition of de novo and salvage energy metabolism pathways] (PubMed id 7941593)9 Szekeres T....Lhotka C. (1994)
    855. Purine enzymes in rheumatoid arthritis: possible association with response to azathioprine. A pilot study. (PubMed id 7979599)9 Kerstens P.J....van de Putte L.B. (1994)
    856. Strand- and sequence-specific attenuation of N-methyl-N'-nitro-N-nitrosoguanidine-induced G.C to A.T transitions by expression of human 6-methylguanine-DNA methyltransferase in Chinese hamster ovary cells. (PubMed id 8033107)9 Yang J.L....Tseng H.J. (1994)
    857. Mutagenicity of metabolic oxygen radicals in mammalian cell cultures. (PubMed id 8001223)9 Gille J.J....Joenje H. (1994)
    858. Metabolism and genotoxicity of the halogenated alkyl compound tris(2,3-dibromopropyl)phosphate. (PubMed id 7718306)9 van Beerendonk G.J....Meerman J.H. (1994)
    859. Enzymes of purine salvage and catabolism in the mouse preimplantation embryo measured by high performance liquid chromatography. (PubMed id 8064675)9 Alexiou M. and Leese H.J. (1994)
    860. Kinds and locations of mutations induced in the hypoxanthine-guanine phosphoribosyltransferase gene of human T-lymphocytes by 1-nitrosopyrene, including those caused by V(D)J recombinase. (PubMed id 8033153)9 McGregor W.G....McCormick J.J. (1994)
    861. Effects of differentiation-inducing agents on purine nucleotide metabolism in an ovarian cancer cell line. (PubMed id 7798296)9 Zoref-Shani E....Nordenberg J. (1994)
    862. Myelin basic protein peptide specificity and T-cell receptor gene usage of HPRT mutant T-cell clones in patients with multiple sclerosis. (PubMed id 7526775)9 Lodge P.A....Sriram S. (1994)
    863. Carcinogen-DNA adducts and gene mutation in foundry workers with low-level exposure to polycyclic aromatic hydrocarbons. (PubMed id 8001254)9 Perera F.P....Hemminki K. (1994)
    864. Somatic mutations at T-cell antigen receptor and glycophorin A loci in pediatric leukemia patients following chemotherapy: comparison with HPRT locus mutation. (PubMed id 7521002)9 Hirota H....Akiyama Y. (1994)
    865. Langerhans'-cell histiocytosis (histiocytosis X)--a clonal proliferative disease. (PubMed id 8008029)9 Willman C.L....Gilliland D.G. (1994)
    866. Longitudinal study of frequency of HPRT mutant T cell s in patients with multiple sclerosis. (PubMed id 8309581)9 Sriram S. (1994)
    867. HPRT yeast artificial chromosome transfer into human cells by four methods and an involvement of homologous recombination. (PubMed id 8185627)9 Wada M....Schlessinger D. (1994)
    868. Comparison of mutation spectra induced by N-ethyl-N-n itrosourea in the hprt gene of Mer+ and Mer- diploid human fibroblasts. (PubMed id 8200099)9 Yang J.L....Lin J.G. (1994)
    869. Induction of mutations at the hypoxanthine phosphoribosyl transferase (HPRT) locus in AHH-1 human lymphoblastoid cells. (PubMed id 7523883)9 Morris S.M....Casciano D.A. (1994)
    870. Normal hypoxanthine and ammonia release from working muscle in partial HPRT deficiency. (PubMed id 7660924)9 Gross M....Gresser U. (1994)
    871. 5'-flanking sequences of the human HPRT gene direct neuronal expression in the brain of transgenic mice. (PubMed id 7523686)9 RincA^n-Limas D.E....Patel P.I. (1994)
    872. Mutagenic processing of psoralen monoadducts differ in normal and Fanconi anemia cells. (PubMed id 8377656)9 Guillouf C....Papadopoulo D. (1993)
    873. Molecular analysis of the mutations in five unrelated patients with the Lesch Nyhan syndrome. (PubMed id 8111415)9 Marcus S....Malm G. (1993)
    874. [Clonality in refractory anemia] (PubMed id 8097542)9 Ohashi H. (1993)
    875. Cytotoxicity, differentiating activity and metabolism of tiazofurin in human neuroblastoma cells. (PubMed id 8344756)9 Pillwein K....Chiba P. (1993)
    876. Effects of low-doses of X-rays on the expression of h uman cell surface CD2 antigen in CD2+ CHO cells. (PubMed id 7902402)9 Kitsiou P....Thomou H. (1993)
    877. Duplication in the hypoxanthine phosphoribosyl-transf erase gene caused by Alu-Alu recombination in a patient with Lesch Nyhan syndro me. (PubMed id 8381385)9 Marcus S....WahlstrAPm J. (1993)
    878. Mapping of the X linked form of hyper IgM syndrome (HIGM1) (PubMed id 8097258)9 Padayachee M....Malcolm S. (1993)
    879. The effect of high-intensity training on purine metabolism in man. (PubMed id 8128888)9 Hellsten-Westing Y....SjAPdin B. (1993)
    880. Cloning and expression of the hypoxanthine-guanine phosphoribosyltransferase gene from Trypanosoma brucei. (PubMed id 8265360)9 Allen T.E. and Ullman B. (1993)
    881. Clonal remissions in acute myeloid leukaemia are commonly associated with features of trilineage myelodysplasia during remission. (PubMed id 7918032)9 Jowitt S.N....Lucas G.S. (1993)
    882. Quantitative relationship between ethylated DNA bases and gene mutation at two loci in CHO cells. (PubMed id 8383034)9 Fortini P....Dogliotti E. (1993)
    883. Molecular analysis of mutations in the hprt gene in circulating lymphocytes from normal and DNA-repair-deficient donors. (PubMed id 7683756)9 Steingrimsdottir H....Lehmann A.R. (1993)
    884. p53 mutation in fresh lymphocytes, B-lymphoblastoid cell lines and their transformed cell lines originating from Bloom syndrome patients. (PubMed id 8330285)9 Shiraishi Y. (1993)
    885. Gout, uric acid and purine metabolism in paediatric nephrology. (PubMed id 8439471)9 Cameron J.S....Simmonds H.A. (1993)
    886. Frequencies of HPRT- lymphocytes and glycophorin A variants erythrocytes in Fanconi anemia patients, their parents and control donors. (PubMed id 7689157)9 Sala-Trepat M....Moustacchi E. (1993)
    887. Clonality in myelodysplastic syndromes: demonstration of pluripotent stem cell origin using X-linked restriction fragment length polymorphisms. (PubMed id 8100140)9 Tsukamoto N....Naruse T. (1993)
    888. Specificity of mutations induced by N-methyl-N-nitrosourea in a cDNA of the hprt gene. (PubMed id 8472339)9 Akagi T....Kato T. (1993)
    889. Molecular genetic evidence of a unifocal origin for h uman serous ovarian carcinomas. (PubMed id 8423021)9 Tsao S.W....Lau C.C. (1993)
    890. Frequency of clonal remission in acute myeloid leukaemia. (PubMed id 8093744)9 Gale R.E....Linch D.C. (1993)
    891. Mutagenicity and mutational spectrum of N-methyl-N'-nitro-N-nitrosoguanidine in the hprt gene in G1-S and late S phase of diploid human fibroblasts. (PubMed id 8504428)9 Yang J.L....Wu C.W. (1993)
    892. Response of MTX-resistant V79 cells to some DNA-damaging agents. (PubMed id 7678892)9 Roy M....Bhattacharjee S.B. (1993)
    893. Evidence from mutation spectra that the UV hypermutab ility of xeroderma pigmentosum variant cells reflects abnormal, error-prone rep lication on a template containing photoproducts. (PubMed id 8321229)9 Wang Y.C....McCormick J.J. (1993)
    894. Analysis of hprt gene mutation following anti-cancer treatment in pediatric patients with acute leukemia. (PubMed id 7692286)9 Hirota H....Mikawa H. (1993)
    895. Mutagenesis after cancer therapy. (PubMed id 8143613)9 Kelsey K.T....Liber H.L. (1993)
    896. Molecular spectrum of background mutation at the hprt locus in human T-lymphocytes. (PubMed id 8450767)9 Hou S.M....Andersson B. (1993)
    897. The HPRT short-term assay in monitoring individuals exposed to genotoxic agents. (PubMed id 8143605)9 Montero R....Ostrosky-Wegman P. (1993)
    898. Red blood cell hypoxanthine phosphoribosyltransferase activity measured using 6-mercaptopurine as a substrate: a population study in children with acute lymphoblastic leukaemia. (PubMed id 12959304)9 Lennard L....Lilleyman J.S. (1993)
    899. Missense mutations and evolutionary conserved amino acids at the human hypoxanthine phosphoribosyl-transferase locus. (PubMed id 1306134)9 Lambert B....Hellgren D. (1992)
    900. The activated human c-Ha-ras-1 oncogene as a mutagen. (PubMed id 1521228)9 Baron H.M....Varshaver N.B. (1992)
    901. Induction of thioguanine-resistant mutations in human uroepithelial cells by 4-aminobiphenyl and its N-hydroxy derivatives. (PubMed id 1311636)9 Bookland E.A....Swaminathan S. (1992)
    902. Mutation analysis and prenatal diagnosis in a Lesch-Nyhan family showing non-random X-inactivation interfering with carrier detection tests. (PubMed id 1618489)9 Marcus S....Francke U. (1992)
    903. Mutagenicity of quinolone antibacterials. (PubMed id 1503668)9 Fort F.L. (1992)
    904. X inactivation as a mechanism of selection against lethal alleles: further investigation of incontinentia pigmenti and X linked lymphoproliferative disease. (PubMed id 1404291)9 Harris A....Bobrow M. (1992)
    905. Protection against AZT-induced mutagenesis at the HGP RT locus in a human cell line by WR-151326. (PubMed id 1544855)9 Grdina D.J....Weichselbaum R. (1992)
    906. Effect of high-dose methotrexate on plasma hypoxanthi ne and uridine levels in patients with acute leukemia or non-Hodgkin lymphoma i n childhood. (PubMed id 1434805)9 Hashimoto H....Mikawa H. (1992)
    907. Induction of 6-thioguanine-resistant mutants in human diploid fibroblasts in vitro with ethylene oxide. (PubMed id 1541259)9 Kolman A....Simons J.W. (1992)
    908. The Lesch-Nyhan syndrome--an under-recognised condition in South Africa? A case report. (PubMed id 1561565)9 Gilbert R.D....Marinaki A. (1992)
    909. Mutational spectrometry: a general approach for hot-spot point mutations in selectable genes. (PubMed id 1584799)9 Keohavong P. and Thilly W.G. (1992)
    910. Wiskott-Aldrich syndrome carrier detection with the hypervariable marker M27 beta. (PubMed id 1350264)9 de Saint Basile G....Fischer A. (1992)
    911. Metabolic fate of hypoxanthine and inosine in cultured cardiomyocytes. (PubMed id 1583701)9 Zoref-Shani E....Sperling O. (1992)
    912. Mapping of the X-linked form of hyper-IgM syndrome (HIGM1) to Xq26 by close linkage to HPRT. (PubMed id 1427881)9 Padayachee M....Malcolm S. (1992)
    913. Factors influencing mutation at the hprt locus in T-l ymphocytes: studies in normal women and women with benign and malignant breast masses. (PubMed id 1600953)9 Branda R.F....Albertini R.J. (1992)
    914. Molecular analysis of clonality in plasma cell dyscrasias. (PubMed id 1520619)9 Miglino M....Ferraris A.M. (1992)
    915. Methylation of HpaII and HhaI sites near the polymorphic CAG repeat in the human androgen-receptor gene correlates with X chromosome inactivation. (PubMed id 1281384)9 Allen R.C....Belmont J.W. (1992)
    916. [Clinical pharmacology of anticancer agents [Part 5] Antimetabolites (2)] (PubMed id 1543370)9 Nakamura T....Uchida M. (1992)
    917. Multiple in vivo footprints are specific to the activ e allele of the X-linked human hypoxanthine phosphoribosyltransferase gene 5' r egion: implications for X chromosome inactivation. (PubMed id 1448069)9 Hornstra I.K. and Yang T.P. (1992)
    918. Charged-particle mutagenesis. 1. Cytotoxic and mutage nic effects of high-LET charged iron particles on human skin fibroblasts. (PubMed id 1734447)9 Tsuboi K....Chen D.J. (1992)
    919. A novel non-radioactive method for detection of nucleoside analog phosphorylation by 5'-nucleotidase. (PubMed id 1430786)9 Fujitaki J.M....Robins R.K. (1992)
    920. The importance of thiopurine methyltransferase activity for the use of azathioprine in transplant recipients. (PubMed id 1585469)9 Chocair P.R....Cameron J.S. (1992)
    921. Functional analysis of brain dopamine systems in a genetic mouse model of Lesch-Nyhan syndrome. (PubMed id 1432691)9 Jinnah H.A....Friedmann T. (1992)
    922. New parental cell lines for generating human hybridomas. (PubMed id 1517591)9 Hundhausen T....MA1ller-Ruchholtz W. (1992)
    923. Comparison of spontaneous mutagenesis in early-passag e human mammary cells from normal and malignant tissues. (PubMed id 1730527)9 Eldridge S.R. and Gould M.N. (1992)
    924. The polyomavirus enhancer activates chromatin accessibility on integration into the HPRT gene. (PubMed id 1333045)9 Pikaart M....Villeponteau B. (1992)
    925. DNA damage and mutation in human cells exposed to nitric oxide in vitro. (PubMed id 1557408)9 Nguyen T....Tannenbaum S.R. (1992)
    926. Elevated hprt mutant frequency in circulating T-lymph ocytes of xeroderma pigmentosum patients. (PubMed id 1372100)9 Cole J....Green M.H. (1992)
    927. In vitro mutational specificity of cisplatin in the h uman hypoxanthine guanine phosphoribosyltransferase gene. (PubMed id 1581901)9 Cariello N.F....Skopek T.R. (1992)
    928. Clonal involvement of granulocytes and monocytes, but not of T and B lymphocytes and natural killer cells in patients with myelodysplasia: analysis by X-linked restriction fragment length polymorphisms and polymerase chain reaction of the phosphoglycerate kinase gene. (PubMed id 1356510)9 van Kamp H....Landegent J.E. (1992)
    929. Determination of point mutational spectra of benzo[a]pyrene-diol epoxide in human cells. (PubMed id 1486852)9 Keohavong P. and Thilly W.G. (1992)
    930. Selective gene mutation in MEL cells. (PubMed id 1370718)9 Foresti M....Geraci G. (1992)
    931. Mutagenic and cytotoxic action of heated pork meat ex tracts in human diploid fibroblasts. (PubMed id 1579070)9 Kolman A....Overvik E. (1992)
    932. Hemimethylation and hypersensitivity are early events in transcriptional reactivation of human inactive X-linked genes in a hamster x human somatic cell hybrid. (PubMed id 1380647)9 Sasaki T....Gartler S.M. (1992)
    933. The human HPRT gene on a yeast artificial chromosome is functional when transferred to mouse cells by cell fusion. (PubMed id 2037299)9 Huxley C....Olson M.V. (1991)
    934. Biological and chemical monitoring of occupational exposure to ethylene oxide. (PubMed id 1719390)9 Tates A.D....Tang Y.S. (1991)
    935. Functional characterization of the human hypoxanthine phosphoribosyltransferase gene promoter: evidence for a negative regulatory element. (PubMed id 1712904)9 RincA^n-Limas D.E....Patel P.I. (1991)
    936. A t(X;15)(q23;q25) with Xq reactivation in a lymphoblastoid cell line from Fanconi anemia. (PubMed id 1855386)9 Kokalj-Vokac N....Dutrillaux B. (1991)
    937. A metabolically competent human cell line expressing five cDNAs encoding procarcinogen-activating enzymes: application to mutagenicity testing. (PubMed id 1793807)9 Crespi C.L....Langenbach R. (1991)
    938. Toxicity, mutagenicity, and mutational spectra of N-e thyl-N-nitrosourea in human cell lines with different DNA repair phenotypes. (PubMed id 1655249)9 Bronstein S.M....Skopek T.R. (1991)
    939. Genotoxic and mutagenic effects of the diagnostic use of thallium-201 in nuclear medicine. (PubMed id 1870614)9 Kelsey K.T....Liber H.L. (1991)
    940. Mutagenicity of 2-amino-N6-hydroxyadenine to TK6 human lymphoblast cells. (PubMed id 1870612)9 Liber H.L. and Denault C.M. (1991)
    941. Somatic cell mutations in atomic bomb survivors. (PubMed id 1762116)9 Akiyama M....Kusunoki Y. (1991)
    942. Comparison of hprt variant frequencies and chromosome aberration frequencies in lymphocytes from radiotherapy and chemotherapy patients: a prospective study. (PubMed id 1879404)9 Ammenheuser M.M....Ward J.B. (1991)
    943. Analysis of mutations using PCR and denaturing gradient gel electrophoresis. (PubMed id 1748086)9 Cariello N.F....Skopek T.R. (1991)
    944. Novel mutational spectrum induced by N-methyl-N'-nitro-N-nitrosoguanidine in the coding region of the hypoxanthine (guanine) phosphoribosyltransferase gene in diploid human fibroblasts. (PubMed id 1920427)9 Yang J.L....Wu C.W. (1991)
    945. Molecular analysis of ultraviolet-induced mutations in a xeroderma pigmentosum cell line. (PubMed id 1992158)9 Dorado G....Lehmann A.R. (1991)
    946. DNA methylation changes in human testicular cancer. (PubMed id 2018791)9 PeltomAoki P. (1991)
    947. 5-Azacytidine inhibits the induction of transient TK-deficient cells by 5-bromodeoxyuridine. A novel hypothesis for the facilitation of hypermethylation by 5-bromodeoxyuridine. (PubMed id 1709444)9 Call K.M. and Thilly W.G. (1991)
    948. Specific locus mutagenesis of human mammary epithelia l cells by ultraviolet radiation. (PubMed id 1672367)9 Eldridge S.R. and Gould M.N. (1991)
    949. Ionizing radiation and genetic risks. III. Nature of spontaneous and radiation-induced mutations in mammalian in vitro systems and mechanisms of induction of mutations by radiation. (PubMed id 2023601)9 Sankaranarayanan K. (1991)
    950. Programmed demethylation in CpG islands during human fetal development. (PubMed id 2011794)9 Migeon B.R....Robinson J.C. (1991)
    951. Mutational analysis of the structure and function of the adenine phosphoribosyltransferase enzyme of Chinese hamster. (PubMed id 1717694)9 de Boer J.G. and Glickman B.W. (1991)
    952. Fidelity of targeted recombination in human fibroblas ts and murine embryonic stem cells. (PubMed id 1896453)9 Zheng H....Bradley A. (1991)
    953. Linkage of the gene for an X-linked mental retardation disorder to a hypervariable (AGAT)n repeat motif within the human hypoxanthine phosphoribosyltransferase (HPRT) locus (Xq26). (PubMed id 1746558)9 Huang T.H....Ledbetter D.H. (1991)
    954. [Comparison of point mutation induced by ethylnitroso urea in human fetus and Syrian hamster pulmonary epithelial cells] (PubMed id 1806343)9 Wen J.M. (1991)
    955. Lack of a cell cycle-dependent strand bias for mutations induced in the HPRT gene by (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene in excision repair-deficient human cells. (PubMed id 1902394)9 Chen R.H....McCormick J.J. (1991)
    956. Excess release of hypoxanthine from exercising muscle in two gout patients with partial HGPRTase deficiency: lack of ammonium release. (PubMed id 2012099)9 Hisatome I....Takeda A. (1991)
    957. Dose-dependent cytotoxic and mutagenic effects of ant ineoplastic alkylating agents on human lymphoblastoid cells. (PubMed id 2050131)9 Sanderson B.J....Henner W.D. (1991)
    958. Analysis of point mutations induced by ultraviolet li ght in human cells. (PubMed id 2067529)9 Keohavong P....Thilly W.G. (1991)
    959. In vivo ionizing irradiations produce deletions in the hprt gene of human T-lymphocytes. (PubMed id 1944353)9 Nicklas J.A....Albertini R.J. (1991)
    960. Autosomal dominant transmission of gouty arthritis with renal disease in a large Japanese family. (PubMed id 1847794)9 Yokota N....Tanaka K. (1991)
    961. The properdin structural locus (Pfc) lies close to the locus for tissue inhibitor of metallothionine proteases (Timp) on the mouse X chromosome. (PubMed id 1916808)9 Laval S.H....Boyd Y. (1991)
    962. Increased methotrexate-induced DNA strand breaks and cytotoxicity following mutational loss of thymidine kinase. (PubMed id 2019462)9 Sano H....Mikawa H. (1991)
    963. The molecular characterisation of HPRT CHERMSIDE and HPRT COORPAROO: two Lesch-Nyhan patients with reduced amounts of mRNA. (PubMed id 1840549)9 Gordon R.B....Gibbs R.A. (1991)
    964. Factors influencing mutation at the hprt locus in T-lymphocytes: women treated for breast cancer. (PubMed id 1742733)9 Branda R.F....Albertini R.J. (1991)
    965. Phenotype reversal in induced mutants of CHO cells: analysis of the reversed cell lines. (PubMed id 2067528)9 Ouellette G. and Bradley W.E. (1991)
    966. Further studies on the purine phosphoribosyltransferase 'burst' velocity reaction. (PubMed id 1854799)9 Montero C. and Llorente P. (1991)
    967. Possible association between mutant frequency in peripheral lymphocytes and domestic radon concentrations. (PubMed id 1673739)9 Bridges B.A....Last R.D. (1991)
    968. A high performance liquid chromatographic assay for AMP-deaminase activity in the erythrocytes of healthy subjects and patients with inherited purine disorders. (PubMed id 1912725)9 Smolenski R.T....Simmonds H.A. (1991)
    969. Molecular analysis of complex human cell populations: mutational spectra of MNNG and ICR-191. (PubMed id 2385237)9 Cariello N.F....Thilly W.G. (1990)
    970. Molecular changes in UV-induced and gamma-ray-induced mutations in human lymphoblastoid cells. (PubMed id 1973821)9 Tachibana A....Tatsumi K. (1990)
    971. Induction of mutations in TK6 human lymphoblastoid cells by ethyl methanesulphonate, benzo[a]pyrene and benzidine. (PubMed id 2184322)9 O'Brien K.A....Tiley M. (1990)
    972. Hypoxanthine guanine phosphoribosyltransferase deficiency: nucleotide substitution causing Lesch-Nyhan syndrome identified for the first time among Japanese. (PubMed id 2323782)9 Fujimori S....Akaoka I. (1990)
    973. Purine salvage enzyme activities in normal and neoplastic human tissues. (PubMed id 2125239)9 Camici M....Ipata P.L. (1990)
    974. Purine synthesis de novo and salvage in hypoxanthine phosphoribosyltransferase-deficient mice. (PubMed id 2095336)9 Allsop J. and Watts R.W. (1990)
    975. Delayed appearance of lethal and specific gene mutati ons in irradiated mammalian cells. (PubMed id 2262367)9 Little J.B....Vetrovs H. (1990)
    976. [Prenatal diagnosis of Lesch-Nyhan syndrome] (PubMed id 2381248)9 Mateos AntA^n F....Romera Menoyo N. (1990)
    977. Clonal analysis of solitary follicular nodules in the thyroid. (PubMed id 1975986)9 Hicks D.G....Kant J.A. (1990)
    978. Patterns of X chromosome inactivation in the Rett syndrome. (PubMed id 2344009)9 Zoghbi H.Y....Fill C. (1990)
    979. Acetaldehyde-induced mutation at the hprt locus in human lymphocytes in vitro. (PubMed id 2209564)9 He S.M. and Lambert B. (1990)
    980. Differential effect of 6-ethylmercaptopurine on c-myc expression in wild-type and HGPRT-deficient HL-60 cells. (PubMed id 2265452)9 French B.T....Trewyn R.W. (1990)
    981. Studies on chromosome aberrations and HPRT mutations in lymphocytes and GPA mutation in erythrocytes of atomic bomb survivors. (PubMed id 2381941)9 Akiyama M....Awa A.A. (1990)
    982. Methylation status of genes flanking the fragile site in males with the fragile-X syndrome: a test of the imprinting hypothesis. (PubMed id 2316521)9 Khalifa M.M....Migeon B.R. (1990)
    983. Sex difference in methylation of single-copy genes in human meiotic germ cells: implications for X chromosome inactivation, parental imprinting, and origin of CpG mutations. (PubMed id 1694309)9 Driscoll D.J. and Migeon B.R. (1990)
    984. Localization of the mouse Mcf-2 (Dbl) protooncogene within a conserved linkage group on the mouse X chromosome. (PubMed id 2265564)9 Grant S.G....Chapman V.M. (1990)
    985. Mutagenic response of Fanconi's anemia cells from a defined complementation group after treatment with photoactivated bifunctional psoralens. (PubMed id 2159378)9 Papadopoulo D....Moustacchi E. (1990)
    986. Genetic effects of 2-aminopurine in mammalian cells. (PubMed id 2188073)9 Speit G....KAPberle B. (1990)
    987. Clonal origin of pituitary adenomas. (PubMed id 1977759)9 Herman V....Melmed S. (1990)
    988. Key enzymes of purine degradation and reutilization in human fetal liver and brain. (PubMed id 2288993)9 Vettenranta K. and Raivio K.O. (1990)
    989. Regulatory elements in the introns of the human HPRT gene are necessary for its expression in embryonic stem cells. (PubMed id 2349238)9 Reid L.H....Koller B.H. (1990)
    990. Hypomutability in Fanconi anemia cells is associated with increased deletion frequency at the HPRT locus. (PubMed id 2236046)9 Papadopoulo D....Moustacchi E. (1990)
    991. Mechanisms of deoxyguanosine lymphotoxicity. Human thymocytes, but not peripheral blood lymphocytes accumulate deoxy-GTP in conditions simulating purine nucleoside phosphorylase deficiency. (PubMed id 2104895)9 Fairbanks L.D....Simmonds H.A. (1990)
    992. T cells responsive to myelin basic protein in patients with multiple sclerosis. (PubMed id 1689076)9 Allegretta M....Albertini R.J. (1990)
    993. Unscheduled DNA synthesis and HPRT mutation in fetal Syrian hamster and human respiratory epithelial cells exposed to ethylnitrosour ea. (PubMed id 2322927)9 Wen J....Mohr U. (1990)
    994. A pitfall in the prenatal diagnosis of Lesch-Nyhan syndrome by chorionic villus sampling. (PubMed id 2343029)9 Page T. and Broock R.L. (1990)
    995. Asynchronous replication of homologous loci on human active and inactive X chromosomes. (PubMed id 2339112)9 Schmidt M. and Migeon B.R. (1990)
    996. HPRT somatic mutation data. (PubMed id 2381927)9 Cole J....Bridges B.A. (1990)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3251 HGNC: 5157 AceView: HPRT1 Ensembl:ENSG00000165704 euGenes: HUgn3251
    ECgene: HPRT1 Kegg: 3251 H-InvDB: HPRT1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    NameDescription
    PharmGKB entry for HPRT1 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/HPRT1
    NIEHS-SNPshttp://egp.gs.washington.edu/data/hprt1/
    Wikipedia http://en.wikipedia.org/wiki/Hypoxanthine-guanine_phosphoribosyltransferase

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