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Aliases for HPR Gene

Aliases for HPR Gene

  • Haptoglobin-Related Protein 2 3
  • Haptoglobin-Related Locus 3
  • A-259H10.2 3
  • HP 3

External Ids for HPR Gene

Previous GeneCards Identifiers for HPR Gene

  • GC16P062990
  • GC16P072830
  • GC16P071832
  • GC16P071873
  • GC16P071883
  • GC16P070665
  • GC16P057863

Summaries for HPR Gene

Entrez Gene Summary for HPR Gene

  • This gene encodes a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer. [provided by RefSeq, Oct 2011]

GeneCards Summary for HPR Gene

HPR (Haptoglobin-Related Protein) is a Protein Coding gene. Diseases associated with HPR include anhaptoglobinemia and glucosephosphate dehydrogenase deficiency. Among its related pathways are amb2 Integrin signaling and Binding and Uptake of Ligands by Scavenger Receptors. GO annotations related to this gene include hemoglobin binding. An important paralog of this gene is HP.

UniProtKB/Swiss-Prot for HPR Gene

  • Primate-specific plasma protein associated with apolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL). This HDL particle, termed trypanosome lytic factor-1 (TLF-1), mediates human innate immune protection against many species of African trypanosomes. Binds hemoglobin with high affinity and may contribute to the clearance of cell-free hemoglobin to allow hepatic recycling of heme iron.

Gene Wiki entry for HPR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HPR Gene

Genomics for HPR Gene

Regulatory Elements for HPR Gene

Genomic Location for HPR Gene

Start:
72,063,224 bp from pter
End:
72,077,246 bp from pter
Size:
14,023 bases
Orientation:
Plus strand

Genomic View for HPR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HPR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HPR Gene

Proteins for HPR Gene

  • Protein details for HPR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P00739-HPTR_HUMAN
    Recommended name:
    Haptoglobin-related protein
    Protein Accession:
    P00739
    Secondary Accessions:
    • Q7LE20
    • Q92658
    • Q92659
    • Q9ULB0

    Protein attributes for HPR Gene

    Size:
    348 amino acids
    Molecular mass:
    39030 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HPR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HPR Gene

Proteomics data for HPR Gene at MOPED

Post-translational modifications for HPR Gene

  • Glycosylation at Asn149 and Asn153
  • Modification sites at PhosphoSitePlus

Other Protein References for HPR Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HPR Gene

Domains for HPR Gene

Suggested Antigen Peptide Sequences for HPR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P00739

UniProtKB/Swiss-Prot:

HPTR_HUMAN :
  • P00739
Domain:
  • The uncleaved signal sequence interacts with HDL fluid lipids and mediates incorporation into the HDL particle.
  • Contains 1 peptidase S1 domain.
  • Contains 1 Sushi (CCP/SCR) domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with HPR: view

No data available for Gene Families for HPR Gene

Function for HPR Gene

Molecular function for HPR Gene

GENATLAS Biochemistry: haptoglobin-related sequence
UniProtKB/Swiss-Prot Function: Primate-specific plasma protein associated with apolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL). This HDL particle, termed trypanosome lytic factor-1 (TLF-1), mediates human innate immune protection against many species of African trypanosomes. Binds hemoglobin with high affinity and may contribute to the clearance of cell-free hemoglobin to allow hepatic recycling of heme iron.

Gene Ontology (GO) - Molecular Function for HPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004252 serine-type endopeptidase activity --
GO:0030492 hemoglobin binding NAS 2987228
genes like me logo Genes that share ontologies with HPR: view

Phenotypes for HPR Gene

GenomeRNAi human phenotypes for HPR:
genes like me logo Genes that share phenotypes with HPR: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HPR Gene

Localization for HPR Gene

Subcellular locations from UniProtKB/Swiss-Prot for HPR Gene

Secreted. Note=Secreted into blood plasma and associated with subtypes of high density lipoproteins (HDL). {ECO:0000269 PubMed:16778136}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HPR Gene COMPARTMENTS Subcellular localization image for HPR gene
Compartment Confidence
extracellular 4
cytosol 2
lysosome 2
mitochondrion 2
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1
peroxisome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for HPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0034366 spherical high-density lipoprotein particle IDA 16682745
GO:0070062 extracellular exosome IDA 23533145
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with HPR: view

Pathways for HPR Gene

genes like me logo Genes that share pathways with HPR: view

Pathways by source for HPR Gene

1 BioSystems pathway for HPR Gene
1 KEGG pathway for HPR Gene

Gene Ontology (GO) - Biological Process for HPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0006508 proteolysis --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0008152 metabolic process IEA --
GO:0098779 activation of mitophagy in response to mitochondrial depolarization IMP 22020285
genes like me logo Genes that share ontologies with HPR: view

Compounds for HPR Gene

(43) Novoseek inferred chemical compound relationships for HPR Gene

Compound -log(P) Hits PubMed IDs
zk112993 91.2 2
ptsh 86.1 10
onapristone 84.6 6
ccpa 77.2 10
progesterone 76.1 77
genes like me logo Genes that share compounds with HPR: view

Transcripts for HPR Gene

mRNA/cDNA for HPR Gene

(1046) Selected AceView cDNA sequences:
(3) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HPR Gene

Haptoglobin-related protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HPR Gene

No ASD Table

Relevant External Links for HPR Gene

GeneLoc Exon Structure for
HPR
ECgene alternative splicing isoforms for
HPR

Expression for HPR Gene

mRNA expression in normal human tissues for HPR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HPR Gene

This gene is overexpressed in Liver (36.9) and Heart - Left Ventricle (7.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HPR Gene

SOURCE GeneReport for Unigene cluster for HPR Gene Hs.655361

mRNA Expression by UniProt/SwissProt for HPR Gene

P00739-HPTR_HUMAN
Tissue specificity: In adult liver the amount of HPR mRNA is at the lower limit of detection, therefore the extent of its expression is at most less than 1000-fold that of the HP1F gene. No HPR mRNA can be detected in fetal liver. Expressed in Hep-G2 and leukemia MOLT-4 cell lines.
genes like me logo Genes that share expressions with HPR: view

Orthologs for HPR Gene

This gene was present in the common ancestor of chordates.

Orthologs for HPR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HPR 35
  • 94.92 (n)
  • 90.52 (a)
HPR 36
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HP 36
  • 65 (a)
OneToMany
dog
(Canis familiaris)
Mammalia HP 36
  • 77 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Hp 36
  • 77 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii hp 36
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 10 (a)
ManyToMany
-- 36
  • 11 (a)
ManyToMany
-- 36
  • 1 (a)
ManyToMany
-- 36
  • 15 (a)
ManyToMany
CSA.10613 36
  • 14 (a)
ManyToMany
Species with no ortholog for HPR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HPR Gene

ENSEMBL:
Gene Tree for HPR (if available)
TreeFam:
Gene Tree for HPR (if available)

Paralogs for HPR Gene

Paralogs for HPR Gene

Selected SIMAP similar genes for HPR Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HPR: view

Variants for HPR Gene

Sequence variations from dbSNP and Humsavar for HPR Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
VAR_014571 -
VAR_057161 -
VAR_057162 -
VAR_057163 -
VAR_057164 -

Structural Variations from Database of Genomic Variants (DGV) for HPR Gene

Variant ID Type Subtype PubMed ID
nsv7285 OTHER Inversion 18451855
nsv833273 CNV Loss 17160897
dgv898e1 CNV Complex 17122850
nsv428329 CNV Gain 18775914
esv2714683 CNV Deletion 23290073
dgv2909n71 CNV Loss 21882294
dgv504e199 CNV Deletion 23128226
nsv827729 CNV Loss 20364138
nsv9456 CNV Gain+Loss 18304495
esv2422047 CNV Duplication 20811451
nsv817737 CNV Loss 17921354
esv23639 CNV Gain+Loss 19812545
esv2215660 CNV Deletion 18987734
esv2478287 CNV Deletion 19546169
esv2714685 CNV Deletion 23290073
nsv1864 CNV Insertion 18451855
nsv436836 CNV Insertion 17901297
nsv514814 CNV Gain 21397061

Relevant External Links for HPR Gene

HapMap Linkage Disequilibrium report
HPR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HPR Gene

Disorders for HPR Gene

(10) Novoseek inferred disease relationships for HPR Gene

Disease -log(P) Hits PubMed IDs
trypanosomiasis african 60 1
endometrial carcinoma 34 3
breast cancer 28.4 11
mammary tumor 27.9 2
endometrial cancer 15.8 1

Relevant External Links for HPR

Genetic Association Database (GAD)
HPR
Human Genome Epidemiology (HuGE) Navigator
HPR
genes like me logo Genes that share disorders with HPR: view

No data available for UniProtKB/Swiss-Prot for HPR Gene

Publications for HPR Gene

  1. Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein. (PMID: 16778136) Nielsen M.J. … Moestrup S.K. (Blood 2006) 2 3 4 23
  2. Nucleotide sequence of the haptoglobin and haptoglobin-related gene pair. The haptoglobin-related gene contains a retrovirus-like element. (PMID: 2987228) Maeda N. (J. Biol. Chem. 1985) 2 3 4
  3. Transcriptionally active haptoglobin-related (Hpr) gene in Hepatoma G2 and leukamia molt-4 cells. (PMID: 8945641) Tabak S. … Shalitin C. (DNA Cell Biol. 1996) 3 4 23
  4. Characterization of the human serum trypanosome toxin, haptoglobin-related protein. (PMID: 9461571) Muranjan M. … Tomlinson S. (J. Biol. Chem. 1998) 3 23
  5. Killing of trypanosomes by the human haptoglobin-related protein. (PMID: 7716520) Smith A.B. … Hajduk S.L. (Science 1995) 3 23

Products for HPR Gene

Sources for HPR Gene

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