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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HPR Gene

protein-coding   GIFtS: 56
GCID: GC16P072097

Haptoglobin-Related Protein

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Haptoglobin-Related Protein1 2
A-259H10.22
HP2
Haptoglobin-Related Locus2

External Ids:    HGNC: 51561   Entrez Gene: 32502   Ensembl: ENSG000002617017   OMIM: 1402105   UniProtKB: P007393   

Export aliases for HPR gene to outside databases

Previous GC identifers: GC16P062990 GC16P072830 GC16P071832 GC16P071873 GC16P071883 GC16P070665 GC16P057863


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HPR Gene:
This gene encodes a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike
haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive
intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and
haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may
also be a clinically important predictor of recurrence of breast cancer. (provided by RefSeq, Oct 2011)

GeneCards Summary for HPR Gene: 
HPR (haptoglobin-related protein) is a protein-coding gene. Diseases associated with HPR include anhaptoglobinemia, and glucosephosphate dehydrogenase deficiency, and among its related super-pathways are Scavenging of Heme from Plasma. GO annotations related to this gene include hemoglobin binding and catalytic activity. An important paralog of this gene is PAMR1.

Gene Wiki entry for HPR Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HPR gene promoter:
         AP-1   ATF-2   Nkx2-5   C/EBPalpha   CREB   SRY   PPAR-gamma1   deltaCREB   PPAR-gamma2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHPR promoter sequence
   Search SABiosciences Chromatin IP Primers for HPR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HPR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.2   HGNC cytogenetic band: 16q22.2

HPR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HPR gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P072097:  view genomic region     (about GC identifiers)

Start:
72,088,522 bp from pter      End:
72,111,145 bp from pter
Size:
22,624 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HPTR_HUMAN, P00739 (See protein sequence)
Recommended Name: Haptoglobin-related protein precursor  
Size: 348 amino acids; 39030 Da
Subcellular location: Secreted (Potential)
Caution: Although homologous to serine proteases, it has lost all essential catalytic residues and has no
enzymatic activity
Secondary accessions: Q7LE20 Q92658 Q92659 Q9ULB0
Alternative splicing: 2 isoforms:  P00739-1   P00739-2   

Explore the universe of human proteins at neXtProt for HPR: NX_P00739

Explore proteomics data for HPR at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P00739

  • HPR Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HPR Protein Expression
    REFSEQ proteins: NP_066275.3  
    ENSEMBL proteins: 
     ENSP00000441828   ENSP00000462916   ENSP00000349451   ENSP00000228226  
    Reactome Protein details: P00739
    Human Recombinant Protein Products for HPR: 
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HPR 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0034366spherical high-density lipoprotein particle IDA16682745

    HPR for ontologies           About GeneDecksing



    HPR Antibody Products: 
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    Abcam antibodies for HPR
    Cloud-Clone Corp. Antibodies for HPR 
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    LSBio Antibodies in human, mouse, rat for HPR 

    Assay Products for HPR: 
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HPR 
    Cloud-Clone Corp. CLIAs for HPR


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR000436 Sushi_SCR_CCP
     IPR001254 Peptidase_S1
     IPR008292 Haptoglobin
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry P00739

    ProtoNet protein and cluster: P00739

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: HPTR_HUMAN, P00739
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 1 peptidase S1 domain
    Similarity: Contains 1 Sushi (CCP/SCR) domain


    HPR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for HPR:
    haptoglobin-related sequence

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity IEA--
    GO:0004252serine-type endopeptidase activity ----
    GO:0030492hemoglobin binding NAS2987228
         
    HPR for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for HPR:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HPR 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HPR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HPR 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HPR 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidHPR 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HPR About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Binding and Uptake of Ligands by Scavenger Receptors
    Scavenging of Heme from Plasma0.63
    Binding and Uptake of Ligands by Scavenger Receptors0.63
    2African trypanosomiasis
    African trypanosomiasis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for HPR
        Scavenging of Heme from Plasma
    Binding and Uptake of Ligands by Scavenger Receptors


    1         Kegg Pathway  (Kegg details for HPR):
        African trypanosomiasis


    HPR for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HPR

    4 Interacting proteins for HPR (P007393) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APOA1P026473I2D: score=1 
    CD40LGP299653I2D: score=1 
    GPS2Q132273I2D: score=1 
    IGHMP018713I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----

    HPR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HPR for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HPR (HPTR)

    10/43 Novoseek inferred chemical compound relationships for HPR gene (see all 43)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zk112993 91.2 2 8387487 (2)
    ptsh 86.1 11 11489868 (3), 10844647 (3), 12405346 (1), 10762262 (1) (see all 6)
    onapristone 84.6 10 8499329 (2), 1557412 (1), 8389450 (1), 9719599 (1) (see all 5)
    ccpa 77.2 11 9334231 (4), 10844647 (2), 16316990 (1), 16505367 (1) (see all 6)
    progesterone 76.1 113 9144411 (3), 8641184 (3), 14667979 (3), 8387487 (2) (see all 63)
    mifepristone 72.6 29 8901556 (4), 8499329 (3), 2249658 (2), 10806733 (2) (see all 12)
    progestin 58.3 5 14611684 (2), 10894152 (2), 2328727 (1)
    progestins 55.7 4 10732331 (1), 10212133 (1), 8389450 (1), 19782484 (1)
    phosphoenolpyruvate 54.2 12 7751285 (2), 12957931 (2), 8246840 (1), 7916965 (1)
    fructose-1,6-bisphosphate 51.3 1 10762262 (1)

    Search CenterWatch for drugs/clinical trials and news about HPR / HPTR

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HPR gene: 
    NM_020995.3  

    Unigene Cluster for HPR:

    Haptoglobin-related protein
    Hs.655361  [show with all ESTs]
    Unigene Representative Sequence: NM_020995
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000540303(uc002fby.3) ENST00000566168 ENST00000561690 ENST00000356967
    ENST00000228226
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HPR
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate HPR
    SwitchGear 3'UTR luciferase reporter plasmidHPR 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HPR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HPR
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    GenScript: all cDNA clones in your preferred vector: HPR (NM_020995)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HPR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HPR
    Sirion Biotech Customized lentivirus for stable overexpression of HPR 
                         Customized lentivirus expression plasmids for stable overexpression of HPR 
    Primer
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    OriGene qPCR primer pairs and template standards for HPR
    OriGene qSTAR qPCR primer pairs in human, mouse for HPR
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HPR
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HPR
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HPR

    12 DOTS entries:

    DT.100891457  DT.87078343  DT.91917890  DT.100891439  DT.120676268  DT.92457420  DT.75121168  DT.92457468 
    DT.420546  DT.92326983  DT.95126987  DT.100891426 

    24/1046 AceView cDNA sequences (see all 1046):

    CB137758 CB137694 BG618639 CB124882 CB114907 CB116958 CB137659 CR622185 
    CB111955 CB147189 CB120391 CB111976 CB130093 AV652245 CB122994 CB147438 
    CB111933 CB116935 CB117084 CB122302 CB137647 T69388 AL558075 CB124812 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HPR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HPR Expression
    About this image


    See HPR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HPR

    SOURCE GeneReport for Unigene cluster: Hs.655361

    UniProtKB/Swiss-Prot: HPTR_HUMAN, P00739
    Tissue specificity: In adult liver the amount of HPR mRNA is at the lower limit of detection, therefore the extent
    of its expression is at most less than 1000-fold that of the HP1F gene. No HPR mRNA can be detected in fetal
    liver. Expressed in Hep-G2 and leukemia MOLT-4 cell lines

        SABiosciences Custom PCR Arrays for HPR
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for HPR gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    zebrafish
    (Danio rerio)
    Actinopterygii hp6
    haptoglobin
    30(a)
    1 → many
    7(57840785-57847584)
            Species with no ortholog for HPR

    ENSEMBL Gene Tree for HPR (if available)
    TreeFam Gene Tree for HPR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HPR gene
    PAMR12  PROZ2  C1S2  C1R2  C1RL2  F92  F102  MASP12  
    F22  F72  PROC2  HP2  MASP22  
    5 SIMAP similar genes for HPR using alignment to 2 protein entries:     HPTR_HUMAN (see all proteins):
    HP    PRSS1    C1R    DKFZp586F0824    C1S

    HPR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/436 SNPs in HPR are shown (see all 436)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs40455521,2
    --57876127(-) GGTGAC/TCCTTA 1 -- int10--------
    rs727870551,2
    --72099362(+) AAGACA/GGAGAA 1 -- int10--------
    rs747946411,2
    C,F--72102041(+) ATGTCG/AATGAT 1 -- int12Minor allele frequency- A:0.04NA EA 240
    rs560305331,2
    C,F--72102183(+) AGGCCG/ACTTAA 1 -- int12Minor allele frequency- A:0.07WA NA 238
    rs794692601,2
    C,F--72103769(+) GGGTAG/AAGACT 1 -- int11Minor allele frequency- A:0.03NA 120
    rs1133926201,2
    F--72104728(+) GTCCCC/TGTGGT 1 -- int12Minor allele frequency- T:0.33CSA 3
    rs727870601,2
    C,F--72105371(+) AATCAT/CGTCAA 1 -- int13Minor allele frequency- C:0.07NA EA 242
    rs713914351,2
    C--72109732(+) CTTTCT/-CTTTT 1 -- int11Minor allele frequency- -:0.50NA 2
    rs1132341311,2
    C--73106924(+) AAACAG/-GGAAG 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs286101931,2
    C,F--73106996(+) GCCTCC/TTCAAA 1 -- us2k15Minor allele frequency- T:0.13NA NS WA 214

    HapMap Linkage Disequilibrium report for HPR (72088522 - 72111145 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/18 variations for HPR (see all 18):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2478287CNV Deletion19546169
    esv2215660CNV Deletion18987734
    dgv504e199CNV Deletion23128226
    esv2714685CNV Deletion23290073
    esv2714683CNV Deletion23290073
    esv2422047CNV Duplication20811451
    nsv436836CNV Insertion17901297
    nsv1864CNV Insertion18451855
    nsv817737CNV Loss17921354
    nsv827729CNV Loss20364138

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 140210    OMIM disorders: --

    20/36 diseases for HPR (see all 36):    About MalaCards
    anhaptoglobinemia    glucosephosphate dehydrogenase deficiency    sickle cell anemia    sleeping sickness
    trypanosomiasis    endometrial adenocarcinoma    endometritis    autoimmune hemolytic anemia
    endometrial carcinoma    mastitis    venous thromboembolism    hemolytic anemia
    anemia    thrombophilia    thromboembolism    breast cancer
    thrombocytopenia    intrahepatic cholangiocarcinoma    vascular disease    cholangiocarcinoma

    16 diseases from the University of Copenhagen DISEASES database for HPR:
    Anemia     Autoimmune hemolytic anemia     Mastitis     Vascular disease
    Cancer     Malaria     Kidney disease     Thrombocytopenia
    Liver disease     Glucosephosphate dehydrogenase deficiency     Arthritis     Tuberculosis
    Sleeping sickness     Heart disease     Endometritis     Diabetes mellitus

    HPR for disorders           About GeneDecksing

    10 Novoseek inferred disease relationships for HPR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trypanosomiasis african 60 1 16896212 (1)
    endometrial carcinoma 34 3 12517594 (1), 11369448 (1), 8650238 (1)
    breast cancer 28.4 14 1862779 (2), 2249658 (1), 1374214 (1), 16452193 (1) (see all 10)
    mammary tumor 27.9 3 2328727 (1), 1862779 (1)
    endometrial cancer 15.8 1 9126867 (1)
    metastasis 4.86 1 1862779 (1)
    cancer 1.62 2 9461571 (1), 17428079 (1)
    shock 0 3 17693714 (2)
    ovarian cancer 0 1 11326686 (1)
    tumors 0 11 9887357 (2), 1862779 (2), 9461571 (1), 1374214 (1) (see all 8)

    Genetic Association Database (GAD): HPR
    Human Genome Epidemiology (HuGE) Navigator: HPR (13 documents)

    Export disorders for HPR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HPR gene, integrated from 9 sources (see all 183):
    (articles sorted by number of sources associating them with HPR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nucleotide sequence of the haptoglobin and haptoglobin-related gene pair. The haptoglobin-related gene contains a retrovirus-like element. (PubMed id 2987228)1, 2, 3 Maeda N. (1985)
    2. Haptoglobin-related protein is a high-affinity hemogl obin-binding plasma protein. (PubMed id 16778136)1, 3, 9 Nielsen M.J....Moestrup S.K. (2006)
    3. Transcriptionally active haptoglobin-related (Hpr) gene in Hepatoma G2 and leukamia molt-4 cells. (PubMed id 8945641)1, 2, 9 Tabak S.... Shalitin C. (1996)
    4. A genome-wide association study identifies rs2000999 a s a strong genetic determinant of circulating haptoglobin levels. (PubMed id 22403646)1, 4 Froguel P....Visvikis-Siest S. (2012)
    5. Biological, clinical and population relevance of 95 l oci for blood lipids. (PubMed id 20686565)1, 4 Teslovich T.M....Kathiresan S. (2010)
    6. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    8. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 2 Loftus B.J.... Adams M.D. (1999)
    9. Junctions between genes in the haptoglobin gene cluster of primates. (PubMed id 1478675)1, 2 Erickson L.M.... Maeda N. (1992)
    10. Structure and expression of the human haptoglobin locus. (PubMed id 4018023)1, 2 Bensi G.... Cortese R. (1985)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3250 HGNC: 5156 AceView: HPandHPR Ensembl:ENSG00000261701 euGenes: HUgn3250
    ECgene: HPR Kegg: 3250 H-InvDB: HPR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HPR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HPR gene:
    Search GeneIP for patents involving HPR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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