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Aliases for HPR Gene

Aliases for HPR Gene

  • Haptoglobin-Related Protein 2 3
  • Haptoglobin-Related Locus 3
  • A-259H10.2 3
  • HP 3

External Ids for HPR Gene

Previous GeneCards Identifiers for HPR Gene

  • GC16P062990
  • GC16P072830
  • GC16P071832
  • GC16P071873
  • GC16P071883
  • GC16P070665
  • GC16P057863

Summaries for HPR Gene

Entrez Gene Summary for HPR Gene

  • This gene encodes a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer. [provided by RefSeq, Oct 2011]

GeneCards Summary for HPR Gene

HPR (Haptoglobin-Related Protein) is a Protein Coding gene. Diseases associated with HPR include anhaptoglobinemia and nutmeg liver. Among its related pathways are amb2 Integrin signaling and Vesicle-mediated transport. GO annotations related to this gene include serine-type endopeptidase activity and hemoglobin binding. An important paralog of this gene is HP.

UniProtKB/Swiss-Prot for HPR Gene

  • Primate-specific plasma protein associated with apolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL). This HDL particle, termed trypanosome lytic factor-1 (TLF-1), mediates human innate immune protection against many species of African trypanosomes. Binds hemoglobin with high affinity and may contribute to the clearance of cell-free hemoglobin to allow hepatic recycling of heme iron.

Gene Wiki entry for HPR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HPR Gene

Genomics for HPR Gene

Regulatory Elements for HPR Gene

Genomic Location for HPR Gene

Chromosome:
16
Start:
72,063,224 bp from pter
End:
72,077,246 bp from pter
Size:
14,023 bases
Orientation:
Plus strand

Genomic View for HPR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HPR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HPR Gene

Proteins for HPR Gene

  • Protein details for HPR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P00739-HPTR_HUMAN
    Recommended name:
    Haptoglobin-related protein
    Protein Accession:
    P00739
    Secondary Accessions:
    • Q7LE20
    • Q92658
    • Q92659
    • Q9ULB0

    Protein attributes for HPR Gene

    Size:
    348 amino acids
    Molecular mass:
    39030 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HPR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HPR Gene

Proteomics data for HPR Gene at MOPED

Post-translational modifications for HPR Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HPR Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HPR Gene

Domains & Families for HPR Gene

Gene Families for HPR Gene

Suggested Antigen Peptide Sequences for HPR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P00739

UniProtKB/Swiss-Prot:

HPTR_HUMAN :
  • The uncleaved signal sequence interacts with HDL fluid lipids and mediates incorporation into the HDL particle.
  • Belongs to the peptidase S1 family.
Domain:
  • The uncleaved signal sequence interacts with HDL fluid lipids and mediates incorporation into the HDL particle.
  • Contains 1 peptidase S1 domain.
  • Contains 1 Sushi (CCP/SCR) domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with HPR: view

Function for HPR Gene

Molecular function for HPR Gene

GENATLAS Biochemistry:
haptoglobin-related sequence
UniProtKB/Swiss-Prot Function:
Primate-specific plasma protein associated with apolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL). This HDL particle, termed trypanosome lytic factor-1 (TLF-1), mediates human innate immune protection against many species of African trypanosomes. Binds hemoglobin with high affinity and may contribute to the clearance of cell-free hemoglobin to allow hepatic recycling of heme iron.

Gene Ontology (GO) - Molecular Function for HPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity --
GO:0030492 hemoglobin binding NAS 2987228
genes like me logo Genes that share ontologies with HPR: view
genes like me logo Genes that share phenotypes with HPR: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HPR

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for HPR Gene

Localization for HPR Gene

Subcellular locations from UniProtKB/Swiss-Prot for HPR Gene

Secreted. Note=Secreted into blood plasma and associated with subtypes of high density lipoproteins (HDL). {ECO:0000269 PubMed:16778136}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HPR Gene COMPARTMENTS Subcellular localization image for HPR gene
Compartment Confidence
extracellular 5
cytosol 3
lysosome 2
vacuole 2
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0034366 spherical high-density lipoprotein particle IDA 16682745
GO:0070062 extracellular exosome IDA 23533145
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with HPR: view

Pathways & Interactions for HPR Gene

genes like me logo Genes that share pathways with HPR: view

Pathways by source for HPR Gene

Gene Ontology (GO) - Biological Process for HPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0006508 proteolysis --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0098779 mitophagy in response to mitochondrial depolarization IGI 22020285
genes like me logo Genes that share ontologies with HPR: view

No data available for SIGNOR curated interactions for HPR Gene

Drugs & Compounds for HPR Gene

(30) Drugs for HPR Gene - From: NovoSeek and ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Prasugrel Approved Pharma ADP receptor inhibitor 160
Ticlopidine Approved Pharma 185
Clopidogrel Approved Nutra P2Y12 receptor antagonist 674
Chloramphenicol Approved Pharma 6
Dexamethasone Approved, Investigational Pharma Agonist 1806

(16) Additional Compounds for HPR Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
adenylate
Carbohydrates
Carbon
Endosulfan
fructose-1,6-bisphosphate
genes like me logo Genes that share compounds with HPR: view

Transcripts for HPR Gene

mRNA/cDNA for HPR Gene

Unigene Clusters for HPR Gene

Haptoglobin-related protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HPR

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HPR Gene

No ASD Table

Relevant External Links for HPR Gene

GeneLoc Exon Structure for
HPR
ECgene alternative splicing isoforms for
HPR

Expression for HPR Gene

mRNA expression in normal human tissues for HPR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HPR Gene

This gene is overexpressed in Liver (x36.9) and Heart - Left Ventricle (x7.4).

Protein differential expression in normal tissues from HIPED for HPR Gene

This gene is overexpressed in Plasma (24.8), Serum (7.9), and Urine (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HPR Gene



SOURCE GeneReport for Unigene cluster for HPR Gene Hs.655361

mRNA Expression by UniProt/SwissProt for HPR Gene

P00739-HPTR_HUMAN
Tissue specificity: In adult liver the amount of HPR mRNA is at the lower limit of detection, therefore the extent of its expression is at most less than 1000-fold that of the HP1F gene. No HPR mRNA can be detected in fetal liver. Expressed in Hep-G2 and leukemia MOLT-4 cell lines.
genes like me logo Genes that share expression patterns with HPR: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for Protein tissue co-expression partners for HPR Gene

Orthologs for HPR Gene

This gene was present in the common ancestor of chordates.

Orthologs for HPR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HPR 35
  • 94.92 (n)
  • 90.52 (a)
HPR 36
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HP 36
  • 65 (a)
OneToMany
dog
(Canis familiaris)
Mammalia HP 36
  • 77 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Hp 36
  • 77 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii hp 36
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10613 36
  • 14 (a)
ManyToMany
-- 36
  • 15 (a)
ManyToMany
-- 36
  • 1 (a)
ManyToMany
-- 36
  • 11 (a)
ManyToMany
-- 36
  • 10 (a)
ManyToMany
Species with no ortholog for HPR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HPR Gene

ENSEMBL:
Gene Tree for HPR (if available)
TreeFam:
Gene Tree for HPR (if available)

Paralogs for HPR Gene

Paralogs for HPR Gene

(5) SIMAP similar genes for HPR Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HPR: view

Variants for HPR Gene

Sequence variations from dbSNP and Humsavar for HPR Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs12646 - 72,077,049(-) CCAGT(C/G)CTGGA reference, missense
rs152829 -- 72,074,174(+) CTATT(C/T)GGGGT intron-variant, upstream-variant-2KB
rs152830 -- 72,074,180(+) GGGGT(A/G)GAAGG intron-variant, upstream-variant-2KB
rs152831 -- 72,074,306(+) CCCCC(C/G/T)GAGAT synonymous-codon, reference, upstream-variant-2KB
rs152832 - 72,074,316(+) TTGCA(A/C)ATGGC reference, missense, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HPR Gene

Variant ID Type Subtype PubMed ID
nsv7285 OTHER Inversion 18451855
nsv833273 CNV Loss 17160897
dgv898e1 CNV Complex 17122850
nsv428329 CNV Gain 18775914
esv2714683 CNV Deletion 23290073
dgv2909n71 CNV Loss 21882294
dgv504e199 CNV Deletion 23128226
nsv827729 CNV Loss 20364138
nsv9456 CNV Gain+Loss 18304495
esv2422047 CNV Duplication 20811451
nsv817737 CNV Loss 17921354
esv23639 CNV Gain+Loss 19812545
esv2215660 CNV Deletion 18987734
esv2478287 CNV Deletion 19546169
esv2714685 CNV Deletion 23290073
nsv1864 CNV Insertion 18451855
nsv436836 CNV Insertion 17901297
nsv514814 CNV Gain 21397061

Variation tolerance for HPR Gene

Residual Variation Intolerance Score: 94.29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.72; 66.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HPR Gene

HapMap Linkage Disequilibrium report
HPR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HPR Gene

Disorders for HPR Gene

MalaCards: The human disease database

(13) MalaCards diseases for HPR Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
anhaptoglobinemia
  • hypohaptoglobinemia
nutmeg liver
  • chronic passive congestion of liver
intracranial vasospasm
  • vasospasm, intracranial
blackwater fever
  • black water fever
geniculate herpes zoster
  • herpes zoster oticus
- elite association
Search HPR in MalaCards View complete list of genes associated with diseases

Relevant External Links for HPR

Genetic Association Database (GAD)
HPR
Human Genome Epidemiology (HuGE) Navigator
HPR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HPR
genes like me logo Genes that share disorders with HPR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HPR Gene

Publications for HPR Gene

  1. Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein. (PMID: 16778136) Nielsen M.J. … Moestrup S.K. (Blood 2006) 2 23 67
  2. The olfactory organ of the trout Salmo trutta fario: a novel localization for a progestin receptor. (PMID: 19725068) Varricchio E. … Paolucci M. (Microsc. Res. Tech. 2010) 23 67
  3. Mechanistic details of a protein-protein association pathway revealed by paramagnetic relaxation enhancement titration measurements. (PMID: 20080627) Fawzi N.L. … Clore G.M. (Proc. Natl. Acad. Sci. U.S.A. 2010) 23 67
  4. Modeling of environmental effects in genome-wide association studies identifies SLC2A2 and HP as novel loci influencing serum cholesterol levels. (PMID: 20066028) Igl W. … Gyllensten U. (PLoS Genet. 2010) 23 67
  5. Progesterone receptor genotype, family history, and spontaneous preterm birth. (PMID: 20308837) Manuck T.A. … Esplin M.S. (Obstet Gynecol 2010) 23 67

Products for HPR Gene

Sources for HPR Gene

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