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HPR Gene(Protein Coding)

Haptoglobin-Related Protein

GCID:
GC16P072097
GIFtS:
56
Genes Participants
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Aliases for HPR Gene

Aliases for HPR Gene

  • Haptoglobin-Related Protein 2 3 5
  • Haptoglobin-Related Locus 3
  • A-259H10.2 3
  • HP 3

External Ids for HPR Gene

Previous GeneCards Identifiers for HPR Gene

  • GC16P062990
  • GC16P072830
  • GC16P071832
  • GC16P071873
  • GC16P071883
  • GC16P070665
  • GC16P057863

Summaries for HPR Gene

Entrez Gene Summary for HPR Gene

  • This gene encodes a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer. [provided by RefSeq, Oct 2011]

GeneCards Summary for HPR Gene

HPR (Haptoglobin-Related Protein) is a Protein Coding gene. Diseases associated with HPR include Anhaptoglobinemia and Trypanosomiasis. Among its related pathways are Vesicle-mediated transport and Binding and Uptake of Ligands by Scavenger Receptors. GO annotations related to this gene include serine-type endopeptidase activity and hemoglobin binding. An important paralog of this gene is HP.

UniProtKB/Swiss-Prot for HPR Gene

  • Primate-specific plasma protein associated with apolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL). This HDL particle, termed trypanosome lytic factor-1 (TLF-1), mediates human innate immune protection against many species of African trypanosomes. Binds hemoglobin with high affinity and may contribute to the clearance of cell-free hemoglobin to allow hepatic recycling of heme iron.

Gene Wiki entry for HPR Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HPR Gene

Genomics for HPR Gene

Products:

  1. Regulatory Element

Regulatory Elements for HPR Gene

Enhancers for HPR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G072072 1 ENCODE 21 +10.0 9990 2.0 FOXA2 ATF1 ARID4B E2F7 DMAP1 ZNF48 TCF12 SLC30A9 PAF1 MXD4 HPR TXNL4B DHX38 DHODH ENSG00000260252
GH16G072012 1.2 Ensembl ENCODE 14.9 -49.5 -49549 2.2 ATF1 TBL1XR1 NFIB ZFP64 SIN3A YY1 TCF12 GATA2 EGR1 FOS TXNL4B HP HPR DHODH DHX38 PIR31360
GH16G072008 1.1 ENCODE 14 -54.4 -54418 1.5 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF302 DHODH DHX38 HPR CMTR2 PIR31360
GH16G072189 1.7 FANTOM5 Ensembl ENCODE dbSUPER 8 +126.8 126812 1.5 HDAC1 PKNOX1 FOXA2 ARID4B RARA ELK1 FOS CREM ZNF362 USF2 IST1 HPR PMFBP1 HP AP1G1 DHX38 ATXN1L LOC105371341
GH16G072124 1.1 Ensembl ENCODE 10 +62.0 62037 1.5 HDGF RB1 TBL1XR1 MLX DMAP1 ZNF48 RAD21 ZNF143 CREM ZNF654 HP DHX38 TXNL4B HPR DHODH PIR57952 PMFBP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HPR on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the HPR gene promoter:

Genomic Location for HPR Gene

Chromosome:
16
Start:
72,063,224 bp from pter
End:
72,077,246 bp from pter
Size:
14,023 bases
Orientation:
Plus strand

Genomic View for HPR Gene

Genes around HPR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HPR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HPR Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for HPR Gene

Proteins for HPR Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for HPR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P00739-HPTR_HUMAN
    Recommended name:
    Haptoglobin-related protein
    Protein Accession:
    P00739
    Secondary Accessions:
    • Q7LE20
    • Q92658
    • Q92659
    • Q9ULB0

    Protein attributes for HPR Gene

    Size:
    348 amino acids
    Molecular mass:
    39030 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HPR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HPR Gene

Protein Expression for HPR Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for HPR Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HPR Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HPR Gene

Domains & Families for HPR Gene

Gene Families for HPR Gene

HGNC:

Protein Domains for HPR Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for HPR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P00739

UniProtKB/Swiss-Prot:

HPTR_HUMAN :
  • The uncleaved signal sequence interacts with HDL fluid lipids and mediates incorporation into the HDL particle.
  • Belongs to the peptidase S1 family.
Domain:
  • The uncleaved signal sequence interacts with HDL fluid lipids and mediates incorporation into the HDL particle.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with HPR: view

Function for HPR Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for HPR Gene

GENATLAS Biochemistry:
haptoglobin-related sequence
UniProtKB/Swiss-Prot Function:
Primate-specific plasma protein associated with apolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL). This HDL particle, termed trypanosome lytic factor-1 (TLF-1), mediates human innate immune protection against many species of African trypanosomes. Binds hemoglobin with high affinity and may contribute to the clearance of cell-free hemoglobin to allow hepatic recycling of heme iron.

Gene Ontology (GO) - Molecular Function for HPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030492 hemoglobin binding NAS,IEA 2987228
genes like me logo Genes that share ontologies with HPR: view
genes like me logo Genes that share phenotypes with HPR: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HPR Gene

Localization for HPR Gene

Subcellular locations from UniProtKB/Swiss-Prot for HPR Gene

Secreted. Note=Secreted into blood plasma and associated with subtypes of high density lipoproteins (HDL). {ECO:0000269 PubMed:16778136}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HPR gene
Compartment Confidence
extracellular 5
lysosome 2
plasma membrane 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for HPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IEA --
GO:0034366 spherical high-density lipoprotein particle IDA 16682745
GO:0070062 extracellular exosome IDA 23533145
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with HPR: view

Pathways & Interactions for HPR Gene

genes like me logo Genes that share pathways with HPR: view

Pathways by source for HPR Gene

1 KEGG pathway for HPR Gene

Gene Ontology (GO) - Biological Process for HPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006898 receptor-mediated endocytosis TAS --
genes like me logo Genes that share ontologies with HPR: view

No data available for SIGNOR curated interactions for HPR Gene

Drugs & Compounds for HPR Gene

Products:

  1. Drug

(37) Drugs for HPR Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ticlopidine Approved Pharma 471
Clopidogrel Approved Nutra P2Y12 receptor antagonist 778
Cytochrome P-450 Enzyme Inhibitors Pharma 3917
Fibrinolytic Agents Pharma 2388
Neurotransmitter Agents Pharma 18340

(15) Additional Compounds for HPR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HPR: view

Transcripts for HPR Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for HPR Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1046) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HPR Gene

Haptoglobin-related protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HPR Gene

No ASD Table

Relevant External Links for HPR Gene

GeneLoc Exon Structure for
HPR
ECgene alternative splicing isoforms for
HPR

Expression for HPR Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HPR Gene

mRNA expression in normal human tissues for HPR Gene
mRNA expression by BioGPS for HPR GenemRNA expression by GTEx for HPR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HPR Gene

This gene is overexpressed in Liver (x36.9) and Heart - Left Ventricle (x7.4).

Protein differential expression in normal tissues from HIPED for HPR Gene

This gene is overexpressed in Plasma (24.8), Serum (7.9), and Urine (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HPR Gene



NURSA nuclear receptor signaling pathways regulating expression of HPR Gene:

HPR

SOURCE GeneReport for Unigene cluster for HPR Gene:

Hs.655361

mRNA Expression by UniProt/SwissProt for HPR Gene:

P00739-HPTR_HUMAN
Tissue specificity: In adult liver the amount of HPR mRNA is at the lower limit of detection, therefore the extent of its expression is at most less than 1000-fold that of the HP1F gene. No HPR mRNA can be detected in fetal liver. Expressed in Hep-G2 and leukemia MOLT-4 cell lines.
genes like me logo Genes that share expression patterns with HPR: view

Primer Products

No data available for Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HPR Gene

Orthologs for HPR Gene

This gene was present in the common ancestor of chordates.

Orthologs for HPR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia HPR 34 35
  • 94.92 (n)
dog
(Canis familiaris)
 Mammalia HP 35
  • 77 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Hp 35
  • 77 (a)
 OneToMany
oppossum
(Monodelphis domestica)
 Mammalia -- 35
  • 68 (a)
 OneToMany
cow
(Bos Taurus)
 Mammalia HP 35
  • 65 (a)
 OneToMany
zebrafish
(Danio rerio)
 Actinopterygii hp 35
  • 29 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 15 (a)
 ManyToMany
CSA.10613 35
  • 14 (a)
 ManyToMany
-- 35
  • 11 (a)
 ManyToMany
-- 35
  • 10 (a)
 ManyToMany
-- 35
  • 1 (a)
 ManyToMany
Species where no ortholog for HPR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HPR Gene

ENSEMBL:
Gene Tree for HPR (if available)
TreeFam:
Gene Tree for HPR (if available)

Paralogs for HPR Gene

Paralogs for HPR Gene

(5) SIMAP similar genes for HPR Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HPR: view

Variants for HPR Gene

Sequence variations from dbSNP and Humsavar for HPR Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000101977 -- 72,073,170(+) CCAAC(C/T)CTAGC intron-variant
rs1000154294 -- 72,072,906(+) TTGCT(C/T)AAGTT intron-variant
rs1000352952 -- 72,067,336(+) AACTT(A/T)TAGTC intron-variant
rs1000683136 -- 72,062,711(+) AGACG(A/G)TCAAA intron-variant, upstream-variant-2KB
rs1000761766 -- 72,062,253(+) AGCAC(C/G)AAGTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HPR Gene

Variant ID Type Subtype PubMed ID
dgv1636e59 CNV duplication 20981092
dgv3017n100 CNV gain 25217958
dgv504e199 CNV deletion 23128226
dgv530e214 CNV gain 21293372
dgv531e214 CNV gain 21293372
dgv532e214 CNV gain 21293372
esv2215660 CNV deletion 18987734
esv23639 CNV gain+loss 19812545
esv2422047 CNV duplication 20811451
esv2478287 CNV deletion 19546169
esv2714683 CNV deletion 23290073
esv2714685 CNV deletion 23290073
esv2758654 CNV gain 17122850
esv3638989 CNV loss 21293372
esv3638992 CNV loss 21293372
esv3892884 CNV loss 25118596
nsv1864 CNV insertion 18451855
nsv428329 CNV gain 18775914
nsv436836 CNV insertion 17901297
nsv514814 CNV gain 21397061
nsv572951 CNV gain 21841781
nsv7285 OTHER inversion 18451855
nsv817737 CNV loss 17921354
nsv827729 CNV loss 20364138
nsv833273 CNV loss 17160897
nsv9456 CNV gain+loss 18304495
nsv978167 CNV duplication 23825009

Variation tolerance for HPR Gene

Residual Variation Intolerance Score: 94.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.72; 66.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HPR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HPR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HPR Gene

Disorders for HPR Gene

MalaCards: The human disease database

(3) MalaCards diseases for HPR Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
anhaptoglobinemia
  • hypohaptoglobinemia
trypanosomiasis
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards
Search HPR in MalaCards View complete list of genes associated with diseases

Relevant External Links for HPR

Genetic Association Database (GAD)
HPR
Human Genome Epidemiology (HuGE) Navigator
HPR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HPR
genes like me logo Genes that share disorders with HPR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HPR Gene

Publications for HPR Gene

  1. Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein. (PMID: 16778136) Nielsen M.J. … Moestrup S.K. (Blood 2006) 2 3 4 22 64
  2. Transcriptionally active haptoglobin-related (Hpr) gene in Hepatoma G2 and leukamia molt-4 cells. (PMID: 8945641) Tabak S. … Shalitin C. (DNA Cell Biol. 1996) 3 4 22 64
  3. Nucleotide sequence of the haptoglobin and haptoglobin-related gene pair. The haptoglobin-related gene contains a retrovirus-like element. (PMID: 2987228) Maeda N. (J. Biol. Chem. 1985) 2 3 4 64
  4. A retained secretory signal peptide mediates high density lipoprotein (HDL) assembly and function of haptoglobin-related protein. (PMID: 25037218) Harrington J.M. … Hajduk S.L. (J. Biol. Chem. 2014) 3 4 64
  5. A genome-wide association study identifies rs2000999 as a strong genetic determinant of circulating haptoglobin levels. (PMID: 22403646) Froguel P. … Visvikis-Siest S. (PLoS ONE 2012) 3 46 64

Products for HPR Gene

Sources for HPR Gene

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