External Ids for HPR Gene
Previous GeneCards Identifiers for HPR Gene
This gene encodes a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer. [provided by RefSeq, Oct 2011]
GeneCards Summary for HPR Gene
HPR (Haptoglobin-Related Protein) is a Protein Coding gene. Diseases associated with HPR include anhaptoglobinemia and glucosephosphate dehydrogenase deficiency. Among its related pathways are amb2 Integrin signaling and Binding and Uptake of Ligands by Scavenger Receptors. GO annotations related to this gene include hemoglobin binding. An important paralog of this gene is HP.
UniProtKB/Swiss-Prot for HPR Gene
Primate-specific plasma protein associated with apolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL). This HDL particle, termed trypanosome lytic factor-1 (TLF-1), mediates human innate immune protection against many species of African trypanosomes. Binds hemoglobin with high affinity and may contribute to the clearance of cell-free hemoglobin to allow hepatic recycling of heme iron.