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HPN Gene

protein-coding   GIFtS: 66
GCID: GC19P035531

Hepsin

  See HPN-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
hepsin1 2     Serine 11
Transmembrane Protease Serine 12 3     Transmembrane Protease1
TMPRSS12 3     Serine Protease Hepsin2
EC 3.4.21.1063 8     EC 3.4.218

External Ids:    HGNC: 51551   Entrez Gene: 32492   Ensembl: ENSG000001057077   OMIM: 1424405   UniProtKB: P059813   

Export aliases for HPN gene to outside databases

Previous GC identifers: GC19P036148 GC19P035980 GC19P040207 GC19P040223 GC19P032039


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HPN Gene:
This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions,
including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is
associated with the growth and progression of cancers, particularly prostate cancer. The protein is cleaved into
a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via
a single disulfide bond. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jan
2013)

GeneCards Summary for HPN Gene:
HPN (hepsin) is a protein-coding gene. Diseases associated with HPN include prostate cancer. GO annotations related to this gene include serine-type peptidase activity and serine-type endopeptidase activity. An important paralog of this gene is TMPRSS11D.

UniProtKB/Swiss-Prot: HEPS_HUMAN, P05981
Function: Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating
cleavage of HGF and MST1/HGFL

Gene Wiki entry for HPN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HPN gene promoter:
         Spz1   Pax-5   AML1a   POU3F1   Lmo2   Max   CREB   deltaCREB   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HPN promoter sequence
   Search Chromatin IP Primers for HPN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HPN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.12   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.12

HPN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HPN gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P035531:  view genomic region     (about GC identifiers)

Start:
35,531,410 bp from pter      End:
35,557,477 bp from pter
Size:
26,068 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HEPS_HUMAN, P05981 (See protein sequence)
Recommended Name: Serine protease hepsin  
Size: 417 amino acids; 45011 Da
5 PDB 3D structures from and Proteopedia for HPN:
1O5E (3D)        1O5F (3D)        1P57 (3D)        1Z8G (3D)        3T2N (3D)    
Secondary accessions: B2RDS4

Explore the universe of human proteins at neXtProt for HPN: NX_P05981

Explore proteomics data for HPN at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn112
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for HPN (P05981) (see all 8)
     WPWQVSL  PGVYTKV  LTAAHCF  VLTAAHC 


    See HPN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_002142.1  NP_892028.1  

    ENSEMBL proteins: 
     ENSP00000262626   ENSP00000376060   ENSP00000472310   ENSP00000470327  

    HPN Human Recombinant Protein Products:

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    Novus Biologicals HPN Protein
    Novus Biologicals HPN Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HPN

     
    Search eBioscience for Proteins for HPN 

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    Search eBioscience for ELISAs for HPN 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TMPRSS: Serine peptidases / Transmembrane

    Selected InterPro protein domains (see all 6):
     IPR001314 Peptidase_S1A
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS
     IPR009003 Trypsin-like_Pept_dom
     IPR017448 Srcr_rcpt-rel

    Graphical View of Domain Structure for InterPro Entry P05981

    ProtoNet protein and cluster: P05981

    3 Blocks protein domains:
    IPB001190 Speract/scavenger receptor
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: HEPS_HUMAN, P05981
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 1 peptidase S1 domain
    Similarity: Contains 1 SRCR domain


    Find genes that share domains with HPN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HEPS_HUMAN, P05981
    Function: Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating
    cleavage of HGF and MST1/HGFL
    Catalytic activity: Cleavage after basic amino-acid residues, with Arg strongly preferred to Lys

         Genatlas biochemistry entry for HPN:
    hepsin,cell membrane associated serine protease,activating factor VII

         Enzyme Numbers (IUBMB): EC 3.4.21.1061 2 EC 3.4.212

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IDA16908524
    GO:0005044scavenger receptor activity IEA--
    GO:0005515protein binding IPI15614436
    GO:0008233peptidase activity IDA16908524
         
    Find genes that share ontologies with HPN           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Hpn):
     endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  homeostasis/metabolism  nervous system 

    Find genes that share phenotypes with HPN           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Hpntm1Qwu for HPN

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HPN
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HPN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HPN

    miRNA
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    miRTarBase miRNAs that target HPN:
    hsa-mir-197-3p (MIRT004197)

    Block miRNA regulation of human, mouse, rat HPN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HPN (see all 15):
    hsa-miR-4311 hsa-miR-16-2* hsa-miR-4318 hsa-miR-492 hsa-miR-548o hsa-miR-548aa hsa-miR-3190 hsa-miR-7
    SwitchGear 3'UTR luciferase reporter plasmidHPN 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HPN

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): HPN (NM_002151)
    Sino Biological Human cDNA Clone for HPN
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HPN

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HPN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HEPS_HUMAN, P05981: Membrane; Single-pass type II membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane5
    cytosol3
    extracellular3
    lysosome1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005789endoplasmic reticulum membrane IDA17918732
    GO:0005886plasma membrane IDA8346233
    GO:0005887integral component of plasma membrane IDA1885621
    GO:0005911cell-cell junction ISS--

    Find genes that share ontologies with HPN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HPN About    
    See pathways by source

    SuperPathContained pathways About
    1Viral carcinogenesis
    Viral carcinogenesis


    Find genes that share SuperPaths with HPN           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for HPN):
        Viral carcinogenesis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HPN: 
              Nitric Oxide Signaling Pathway in human mouse rat
              Hepatotoxicity in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HPN

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for HPN (P059813 ENSP000002626264) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    F7P087093, ENSP000003647314I2D: score=2 STRING: ENSP00000364731
    HGFP142103, ENSP000002223904I2D: score=1 STRING: ENSP00000222390
    WIPI1Q5MNZ93I2D: score=1 
    IGHG1ENSP000003749904STRING: ENSP00000374990
    IGLC2ENSP000003748564STRING: ENSP00000374856
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IDA16908524
    GO:0008360regulation of cell shape IMP8346233
    GO:0010628positive regulation of gene expression ISS--
    GO:0010719negative regulation of epithelial to mesenchymal transition IDA19843851
    GO:0010756positive regulation of plasminogen activation IDA16908524

    Find genes that share ontologies with HPN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HPN (HEPS)

    5 DrugBank Compounds for HPN    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    BentiromideBentiromide [USAN:BAN:INN:JAN] (see all 5)37106-97-1targetligand12641496 6371722 10592235 3258344
    Coagulation factor VIIaCoagulation factor VII precursor (see all 5)9001-25-6target--17139284 17016423
    6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine-- --target--10592235
    Benzylsulfinic Acid-- --target--10592235
    CRA_1144-- --target--10592235

    4 Novoseek inferred chemical compound relationships for HPN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 74.2 53 9395459 (3), 12629351 (2), 20015050 (2), 15614436 (2) (see all 37)
    benzamidine 69.2 1 17388811 (1)
    agar 9.77 3 12460890 (1), 16391794 (1), 18698500 (1)
    threonine 0 1 15839837 (1)



    Find genes that share compounds with HPN           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HPN gene (2 alternative transcripts): 
    NM_002151.2  NM_182983.2  

    Unigene Cluster for HPN:

    Hepsin
    Hs.182385  [show with all ESTs]
    Unigene Representative Sequence: AK125670
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262626(uc002nxr.2) ENST00000392226(uc002nxq.2 uc010xsh.1 uc002nxt.1)
    ENST00000600390 ENST00000597419 ENST00000599363 ENST00000596662 ENST00000541345
    ENST00000593305 ENST00000600675
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate HPN (see all 15):
    hsa-miR-4311 hsa-miR-16-2* hsa-miR-4318 hsa-miR-492 hsa-miR-548o hsa-miR-548aa hsa-miR-3190 hsa-miR-7
    SwitchGear 3'UTR luciferase reporter plasmidHPN 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HPN
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    GenScript: all cDNA clones in your preferred vector (see all 2): HPN (NM_002151)
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      QuantiFast Probe-based Assays in human, mouse, rat HPN

    Additional mRNA sequence: 

    AK125670.1 AK315655.1 BC025716.1 EU644753.1 M18930.1 X07002.1 X07732.1 

    15 DOTS entries:

    DT.91760387  DT.100817702  DT.95179900  DT.97841550  DT.101958126  DT.101971861  DT.92067980  DT.91760385 
    DT.95111479  DT.95179906  DT.100649945  DT.305869  DT.40132709  DT.91760386  DT.95090067 

    Selected AceView cDNA sequences (see all 108):

    AA693970 AL558100 CR597177 CR592189 BX406458 AI685007 NM_182983 BU688738 
    BM548649 BM994658 BX422288 F10182 AI289181 AX747294 CB162030 AL697924 
    X07002 BM805235 NM_002151 BI768246 AI826254 AW613055 AL557891 BI517769 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HPN (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                          -                       -           -                             -                                             
    SP2:                                                  -           -                             -                                             
    SP3:                                                              -                                                                           
    SP4:                                                  -           -                             -                                             
    SP5:                                                  -           -                                                                           


    ECgene alternative splicing isoforms for HPN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HPN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATATTGT
    HPN Expression
    About this image

    HPN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HPN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.182385

    UniProtKB/Swiss-Prot: HEPS_HUMAN, P05981
    Tissue specificity: Present in most tissues, with the highest level in liver

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HPN: 
              Nitric Oxide Signaling Pathway in human mouse rat
              Hepatotoxicity in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HPN
    OriGene qSTAR qPCR primer pairs in human, mouse for HPN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HPN
    QuantiTect SYBR Green Assays in human, mouse, rat HPN
    QuantiFast Probe-based Assays in human, mouse, rat HPN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HPN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HPN gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hpn1 , 5 hepsin1, 5 84.67(n)1
    88.86(a)1
      7 (19.30 cM)5
    154511  NM_008281.41  NP_032307.21 
     310987255 
    chicken
    (Gallus gallus)
    Aves HPN6
    hepsin
    34(a)
    1 ↔ 1
    1(98898052-98906375)
    lizard
    (Anolis carolinensis)
    Reptilia HPN6
    hepsin
    68(a)
    1 ↔ 1
    GL343276.1(5004-22070)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005361541 serine protease hepsin-like 59.04(n)
    54.47(a)
      100536154  XM_003200259.2  XP_003200307.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0045681 AgaP_AGAP004568 48.54(n)
    42.98(a)
      1274710  XM_313873.5  XP_313873.5 


    ENSEMBL Gene Tree for HPN (if available)
    TreeFam Gene Tree for HPN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HPN gene
    TMPRSS11D2  TMPRSS32  TMPRSS11B2  TMPRSS62  TMPRSS11A2  TMPRSS72  TMPRSS52  TMPRSS42  
    ST142  TMPRSS132  TMPRSS11E2  KLKB12  TMPRSS22  F112  TMPRSS152  TMPRSS11F2  
    Selected SIMAP similar genes for HPN using alignment to 4 protein entries:     HEPS_HUMAN (see all proteins) (see all similar genes):
    DKFZp586F0824    DKFZp779M0222    F12    HP    TMPRSS11A    TMPRSS11F
    CTRB1    KLKB1    CTRL    TMPRSS3    CTRB2    OVCH1
    TMPRSS11B    ELA2A    CELA2A    TMPRSS13    DESC1    ST14

    Find genes that share paralogs with HPN           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HPN (see all 372)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1816984561,2
    --32037458(+) AAGCAC/TGTTAC 2 -- us2k10--------
    rs725502561,2
    C,F--35531942(+) GGGCCG/ACGCCT 2 -- int13Minor allele frequency- A:0.14NA EA 990
    rs725502571,2
    C,F--35531984(+) GCGGAC/TGCTTC 2 -- int12Minor allele frequency- T:0.01WA 868
    rs1927869931,2
    --35532101(+) CCGGGC/TGGAGG 2 -- int10--------
    rs621221581,2
    C--35532254(+) TGGCGG/AGCACA 2 -- int14Minor allele frequency- A:0.08NA EA 988
    rs1842445981,2
    --35532255(+) GGCGGA/GCACAG 2 -- int10--------
    rs23057491,2
    C,F--35532305(+) AAGGGT/GTCGCT 2 -- int17Minor allele frequency- G:0.39NA CSA WA EA 1109
    rs23057501,2
    C--35532314(+) CTGGGT/CGAGGG 2 -- int15Minor allele frequency- C:0.29CSA WA NA EA 1106
    rs725502601,2
    F--35532386(+) TTCAGC/ACTGCA 2 -- int11Minor allele frequency- A:0.00--696
    rs1887724271,2
    --35532389(+) AGCCTA/GCACTT 2 -- int10--------

    HapMap Linkage Disequilibrium report for HPN (35531410 - 35557477 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for HPN:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718489CNV Deletion23290073
    nsv911613CNV Loss21882294
    dgv3848n71CNV Loss21882294
    nsv911610CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142440    OMIM disorders: --

    1 disease for HPN:    
    About MalaCards
    prostate cancer

    2 diseases from the University of Copenhagen DISEASES database for HPN:
    Prostate cancer     Short bowel syndrome

    Find genes that share disorders with HPN           About GenesLikeMe

    Selected Novoseek inferred disease relationships for HPN gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 70.7 63 16783571 (4), 14665873 (4), 18784072 (4), 17569629 (4) (see all 26)
    benign prostatic hyperplasia 50.5 2 14665873 (1), 15609297 (1)
    prostatic adenocarcinoma 47.3 2 19938013 (1), 18338334 (1)
    cancer 41 7 20015050 (1), 18338334 (1), 12023851 (1), 17569629 (1) (see all 7)
    metastasis 38.4 17 19938013 (2), 15324701 (2), 18852137 (2), 18784072 (2) (see all 10)
    aggressiveness 36.9 2 16783571 (1), 14665873 (1)
    tumors 26.2 40 18784072 (4), 19938013 (3), 16585186 (3), 9230195 (2) (see all 16)
    ovarian carcinoma 24.9 1 18383840 (1)
    primary tumor 24.9 3 19938013 (1), 12962630 (1), 16585186 (1)
    carcinoma renal cell 22.3 5 15538223 (2), 17309599 (2), 9569208 (1)

    Genetic Association Database (GAD): HPN
    Human Genome Epidemiology (HuGE) Navigator: HPN (5 documents)

    Export disorders for HPN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HPN gene, integrated from 10 sources (see all 115):
    (articles sorted by number of sources associating them with HPN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel trypsin-like serine protease (hepsin) with a putative transmembrane domain expressed by human liver and hepatoma cells. (PubMed id 2835076)1, 2, 3 Leytus S.P.... Davie E.W. (Biochemistry 1988)
    2. Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers. (PubMed id 15839837)1, 2, 9 Herter S....Austin R.J. (Biochem. J. 2005)
    3. Genes involved in the transforming growth factor beta signalling pathway and the risk of intracranial aneurysms. (PubMed id 18487557)1, 4, 9 Ruigrok Y.M....Wijmenga C. (J. Neurol. Neurosurg. Psychiatr. 2008)
    4. Hepsin, a cell membrane-associated protease. Characterization, tissue distribution, and gene localization. (PubMed id 1885621)1, 2, 9 Tsuji A.... Kurachi K. (J. Biol. Chem. 1991)
    5. Association of hepsin gene variants with prostate cancer risk and prognosis. (PubMed id 20166135)1, 4, 9 Holt S.K....Stanford J.L. (Prostate 2010)
    6. Variants in the HEPSIN gene are associated with prostate cancer in men of European origin. (PubMed id 16783571)1, 4, 9 Pal P....Deka R. (Hum. Genet. 2006)
    7. Analysis of candidate genes for prostate cancer. (PubMed id 15583422)1, 4, 9 Burmester J.K....Catalona W.J. (Hum. Hered. 2004)
    8. Proteolytic activation of pro-macrophage-stimulating protein by hepsin. (PubMed id 21875933)1, 2 Ganesan R.... Kirchhofer D. (Mol. Cancer Res. 2011)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3249 HGNC: 5155 AceView: HPN Ensembl:ENSG00000105707 euGenes: HUgn3249
    ECgene: HPN Kegg: 3249 H-InvDB: HPN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HPN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HPN Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HPN gene:
    Search GeneIP for patents involving HPN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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