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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HPGDS Gene

protein-coding   GIFtS: 60
GCID: GC04M095219

hematopoietic prostaglandin D synthase
 Explore 8 diseases affiliated with
HPGDS via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HPGDS    

Aliases
for HPGDS gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Hematopoietic Prostaglandin D Synthase1 2     GST Class-Sigma2 3
PGDS1 2 3 5     Glutathione S-Transferase Sigma2
GSTS1 2 3     Glutathione-Dependent PGD Synthetase2
GSTS1-11 2     Hematopoietic Prostaglandin D2 Synthase2
PGD21 2     EC 2.5.1.183
H-PGDS1 3     EC 5.3.99.23
Glutathione-Dependent PGD Synthase2 3     PTGDS23
Glutathione-Requiring Prostaglandin D Synthase2 3     Glutathione S-Transferase3
Prostaglandin-H2 D-Isomerase2 3     

External Ids:    HGNC: 178901   Entrez Gene: 273062   Ensembl: ENSG000001631067   OMIM: 6025985   UniProtKB: O607603   

Export aliases for HPGDS gene to outside databases

Previous GC identifers: GC04M095439 GC04M090957


Summaries
for HPGDS gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HPGDS:
Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion
of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of
this enzyme can be used to identify the differentiation stage of human megakaryocytes. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HPGDS_HUMAN, O60760
Function: Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth
muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with
a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards
cumene hydroperoxide

Gene Wiki entry for HPGDS (PGDS)


Genomic Views
for HPGDS gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for HPGDS
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HPGDS promoter sequence
   Search SABiosciences Chromatin IP Primers for HPGDS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HPGDS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q22.3   Ensembl cytogenetic band:  4q22.3   HGNC cytogenetic band: 4q22.2

HPGDS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HPGDS gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M095219:  view genomic region     (about GC identifiers)

Start:
 95,219,686 bp from pter      End:
 95,264,027 bp from pter
Size:
 44,342 bases      Orientation:
 minus strand

Proteins
for HPGDS gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HPGDS_HUMAN, O60760 (See protein sequence)
Recommended Name: Hematopoietic prostaglandin D synthase  
Size: 199 amino acids; 23344 Da
Cofactor: Glutathione. Required for the prostaglandin D synthase activity
Subunit: Homodimer
Subcellular location: Cytoplasm
Developmental stage: Highest levels in immature megakaryocytic cells. Disappears after final differentiation to
platelets
6/18 PDB 3D structures from and Proteopedia for HPGDS (see all 18):
1IYH (3D)        1IYI (3D)        1V40 (3D)        2CVD (3D)        2VCQ (3D)        2VCW (3D)    
Secondary accessions: Q6FHT9

Explore the universe of human proteins at neXtProt for HPGDS: NX_O60760

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O60760

    • HPGDS Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055300.1  
    ENSEMBL proteins: 
     ENSP00000295256  
    Reactome Protein details: O60760
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for HPGDS (Hematopoietic Prostaglandin D Synthase/HPGDS)
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    OriGene Protein Over-expression Lysate: HPGDS
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    Novus Biologicals HPGDS Proteins
    Novus Biologicals HPGDS Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for HPGDS
    Uscn Proteins for HPGDS

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--


    HPGDS for ontologies           About GeneDecksing



    HPGDS Antibody Products: 
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    Uscn ELISAs and CLIAs for HPGDS

    Protein Domains /
    Families
    for HPGDS gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HPGDS for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR012336 Thioredoxin-like_fold
     IPR004046 GST_C
     IPR017933 Glutathione_S_Trfase/Cl_chnl_C
     IPR004045 Glutathione_S-Trfase_N
     IPR010987 Glutathione-S-Trfase_C-like

    Graphical View of Domain Structure for InterPro Entry O60760

    ProtoNet protein and cluster: O60760

    1 Blocks protein family: IPB004045 Glutathione S-transferase

    UniProtKB/Swiss-Prot: HPGDS_HUMAN, O60760
    Similarity: Belongs to the GST superfamily. Sigma family
    Similarity: Contains 1 GST C-terminal domain
    Similarity: Contains 1 GST N-terminal domain


    Function
    for HPGDS gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HPGDS_HUMAN, O60760
    Function: Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth
    muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with
    a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards
    cumene hydroperoxide
    Catalytic activity: (5Z,13E,15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate =
    (5Z,13E,15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
    Catalytic activity: RX + glutathione = HX + R-S-glutathione
    Enzyme regulation: Prostaglandin PGD2 synthesis is stimulated by calcium and magnesium ions. One calcium or magnesium
    ion is bound between the subunits of the homodimer. The interactions with the protein are for the most part mediated
    via water molecules. Magnesium increases the affinity for glutathione, while calcium has no effect on the affinity for
    glutathione
    Biophysicochemical properties: Kinetic parameters: KM=8 mM for glutathione for the glutathione-conjugating activity;
    KM=0.6 mM for glutathione for the prostaglandin D synthase activity in the presence of EDTA; KM=0.14 mM for
    glutathione for the prostaglandin D synthase activity in the presence of magnesium ions; Vmax=8.6 umol/min/mg enzyme
    with 1-bromo-2,4-dinitrobenzene as substrate; Vmax=5.1 umol/min/mg enzyme with 1-chloro-2,4-dinitrobenzene as
    substrate; Vmax=44.3 umol/min/mg enzyme with 1-fluoro-2,4-dinitrobenzene as substrate; Vmax=10.7 umol/min/mg enzyme
    with 1-iodo-2,4-dinitrobenzene as substrate; Vmax=6.8 umol/min/mg enzyme with allyl isothiocyanate as substrate;
    Vmax=6.3 umol/min/mg enzyme with benzyl isothiocyanate as substrate; Vmax=0.05 umol/min/mg enzyme with cumene
    hydroperoxide as substrate;
    Induction: By 12-O-tetradecanoylphorbol-13-acetate (TPA)

    Enzyme Numbers (IUBMB): EC 2.5.1.181 EC 5.3.99.21

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HPGDS
    1 QIAGEN miScript miRNA Assays for microRNA that regulate HPGDS:
    hsa-miR-491-3p
    SwitchGear 3'UTR luciferase reporter plasmid: HPGDS 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HPGDS (see all 4)
    OriGene shRNA RFP: HPGDS
    OriGene siRNA: HPGDS
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for HPGDS

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HPGDS

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA12627223
    GO:0004364glutathione transferase activity IEA--
    GO:0004667prostaglandin-D synthase activity IDA12627223
    GO:0005509calcium ion binding IDA12627223
    GO:0042803protein homodimerization activity IPI12627223


    HPGDS for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for HPGDS:
     Decreased G3BP1 protein expres 

    Animal Models:
         Mouse knock-out Hpgdstm1Urad for HPGDS
         7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Hpgds):
     behavior/neurological  cellular  immune system  integument  mortality/aging 
     nervous system  tumorigenesis 

    HPGDS for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HPGDS gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
    		Synthesis of Prostaglandins (PG) and Thromboxanes (TX)1.00
    		Prostaglandin 2 biosynthesis and metabolism FM0.44
    		prostanoid biosynthesis0.50
    		Prostaglandin 2 biosynthesis and metabolism FM0.44
    2Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    		Metabolic pathways0.38
    3Arachidonic acid metabolism
    		Arachidonic acid metabolism1.00
    		Arachidonic acid metabolism0.42
    4Integrated Pancreatic Cancer Pathway
    		Integrated Pancreatic Cancer Pathway1.00
    		Integrated Pancreatic Cancer Pathway0.99
    5Celecoxib Pathway, Pharmacodynamics
    		Celecoxib Pathway, Pharmacodynamics1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for HPGDS
        Prostaglandin 2 biosynthesis and metabolism FM


    1 GeneGo (Thomson Reuters) Pathway for HPGDS
        Prostaglandin 2 biosynthesis and metabolism FM

    3 BioSystems Pathways for HPGDS 
        Integrated Pancreatic Cancer Pathway
    Integrated Pancreatic Cancer Pathway
    prostanoid biosynthesis

    4        Reactome Pathways for HPGDS
        Metabolism
    Arachidonic acid metabolism
    Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
    Metabolism of lipids and lipoproteins

    1 PharmGKB Pathway for HPGDS
        Celecoxib Pathway, Pharmacodynamics

    2         Kegg Pathways  (Kegg details for HPGDS):
        Arachidonic acid metabolism
    Metabolic pathways


    HPGDS for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HPGDS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/14 Interacting proteins for HPGDS (O607603 ENSP000002952564) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HK3P527903, ENSP000002924324I2D: score=2 STRING: ENSP00000292432
    AKR1C3ENSP000003699274STRING: ENSP00000369927
    PTGESENSP000003423854STRING: ENSP00000342385
    PTGES2ENSP000003453414STRING: ENSP00000345341
    PTGISENSP000002440434STRING: ENSP00000244043
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001516prostaglandin biosynthetic process IEA--
    GO:0006693prostaglandin metabolic process IDA12627223
    GO:0007165signal transduction NAS9353279
    GO:0007626locomotory behavior TAS10781097


    HPGDS for ontologies           About GeneDecksing



    Drugs & Compounds
    for HPGDS gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HPGDS

    3 HMDB Compounds for HPGDS    About this table
    CompoundSynonyms CAS #PubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Prostaglandin D2prostaglandin d2 (see all 22)41598-07-6--
    Prostaglandin H2Prostaglandin-H2 (see all 27)42935-17-1--

    10/11 DrugBank Compounds for HPGDS (see all 11)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8target--16547010 8415655 17139284 17016423 15113825 10592235
    2-(2f-Benzothiazolyl)-5-Styryl-3-(4f-Phthalhydrazidyl)Tetrazolium Chloride-- --target--17139284 17016423
    Glycerol-- --target--17139284 17016423
    1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID-- --target--10592235
    2-{[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino}benzoic acid-- --target--10592235
    3-(4-nitrophenyl)-1H-pyrazole-- --target--10592235
    3-phenyl-5-(1H-pyrazol-3-yl)isoxazole-- --target--10592235
    4-(BENZHYDRYLOXY)-1-[3-(1H-TETRAAZOL-5-YL)PROPYL]PIPERIDINE-- --target--10592235
    4-{[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino}-2-hydroxybenzoic acid-- --target--10592235
    PHENYL-5-(1H-PYRAZOL-3-YL)-1,3-THIAZOLE-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about HPGDS 

    Transcripts
    for HPGDS gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HPGDS gene: 
    NM_014485.2  

    Unigene Cluster for HPGDS:

    Hematopoietic prostaglandin D synthase
    Hs.128433  [show with all ESTs]
    Unigene Representative Sequence: NM_014485
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295256(uc003hte.1) ENST00000514774 ENST00000506331

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: HPGDS 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK290075.1 BC020734.1 CR541662.1 CR541679.1 D82073.1 

    1 DOTS entry:

    DT.104108 

    24/37 AceView cDNA sequences (see all 37):

    AA975424 BF593044 AI378572 BX358964 CB989915 AW082637 BG189654 BG285251 
    AL545369 AL550785 CR619711 BG191182 AL574552 BG199903 NM_014485 CR622166 
    AI695266 BX380262 D82073 AI206447 BG620473 CB997397 CR541662 CR541679 

    GeneLoc Exon Structure


    Expression
    for HPGDS gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HPGDS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTCCCTCCCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HPGDS expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Trophoblast-like cells (Generation of tropho...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HPGDS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HPGDS

    SOURCE GeneReport for Unigene cluster: Hs.128433

    UniProtKB/Swiss-Prot: HPGDS_HUMAN, O60760
    Tissue specificity: Expressed in a number of megakaryocytic cell lines but not in platelets. Highly expressed in
    adipose tissue, macrophages and placenta. Also expressed at lower levels in lung, heart, lymph nodes, appendix, bone
    marrow and fetal liver

        SABiosciences Custom PCR Arrays for HPGDS
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HPGDS

    Orthologs
    for HPGDS gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for HPGDS gene from 4/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Hpgds1 , 5 hematopoietic prostaglandin D synthase1, 5 82.24(n)1
    80.4(a)1    		   6 (30.11 cM)5
    544861  NM_019455.41  NP_062328.31 
     651172935 
    chicken
    (Gallus gallus)    		 Aves HPGDS1 hematopoietic prostaglandin D synthase 69.35(n)
    66.33(a)    		   395863  NM_205011.1  NP_990342.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta GstS11 Glutathione S transferase S1 48.11(n)
    38.66(a)    		   36927  NM_079043.2  NP_523767.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea gst-51 Protein GST-5 45.96(n)
    41.05(a)    		   187537  NM_063956.4  NP_496357.1 


    ENSEMBL Gene Tree for HPGDS (if available)
    TreeFam Gene Tree for HPGDS (if available) 

    Paralogs
    for HPGDS gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HPGDS gene
    GSTA42  GSTA52  GSTA32  GSTA12  GSTM12  GSTM32  GSTA22  GSTP12  
    GSTM42  GSTM52  GSTM22  

    HPGDS for paralogs           About GeneDecksing



    Genomic Variants
    for HPGDS gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HPGDS
    DNA2.0 Custom Variant and Variant Library Synthesis for HPGDS

    Disorders / Diseases
    for HPGDS gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HPGDS for disorders           About GeneDecksing

    OMIM gene information: 602598    OMIM disorders: --

    8 diseases for HPGDS:    About MalaCards
    intestinal volvulus    breast cancer susceptibility    breast cancer    hermaphroditism
    endometriosis    infertility    asthma    malaria

    2 diseases from the University of Copenhagen DISEASES database for HPGDS:
    Cancer     Malaria
    Human Genome Epidemiology (HuGE) Navigator: HPGDS (0 documents)

    Export disorders for HPGDS gene to outside databases

    Publications
    for HPGDS gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HPGDS gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with HPGDS)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Mammalian class Sigma glutathione S-transferases: catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D2 synthases. (PubMed id 11672424)1, 2, 3, 9 Jowsey I.R....Hayes J.D. (2001)
    2. First determination of the inhibitor complex structure of human hematopoietic prostaglandin D synthase. (PubMed id 15113825)1, 2, 7 Inoue T....Urade Y. (2004)
    3. Prostaglandin D synthase in human megakaryoblastic cells. (PubMed id 9353279)1, 2, 3 Mahmud I.... Hayaishi O. (1997)
    4. Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase. (PubMed id 10824118)1, 2, 9 Kanaoka Y....Hayaishi O. (2000)
    5. Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. (PubMed id 16547010)2, 7 Aritake K.... Urade Y. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Mechanism of metal activation of human hematopoietic prostaglandin D synthase. (PubMed id 12627223)1, 2 Inoue T....Urade Y. (2003)
    8. Induction of hematopoietic prostaglandin D synthase in human megakaryocytic cells by phorbol ester. (PubMed id 9425264)1, 2 Suzuki T.... Hayaishi O. (1997)
    9. Novel prostaglandin D synthase inhibitors generated b y fragment-based drug design. (PubMed id 18341273)2, 9 Hohwy M....Edman K. (2008)
    10. Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase. (PubMed id 19939518)2, 9 Weber J.E....Flanagan J.U. (2010)

    External Searches for HPGDS gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HPGDS gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27306 HGNC: 17890 AceView: PGDS Ensembl:ENSG00000163106 euGenes: HUgn27306
    ECgene: HPGDS Kegg: 27306 H-InvDB: HPGDS

    Other Databases showing HPGDS gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HPGDS gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HPGDS Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HPGDS gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HPGDS gene:
    Search GeneIP for patents involving HPGDS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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