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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HPGDS Gene

protein-coding   GIFtS: 61
GCID: GC04M095219

Hematopoietic Prostaglandin D Synthase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Hematopoietic Prostaglandin D Synthase1 2     PGD22
PGDS2 3 5     Glutathione-Dependent PGD Synthetase2
Glutathione S-Transferase Sigma1 2     Hematopoietic Prostaglandin D2 Synthase2
Glutathione-Dependent PGD Synthase2 3     EC 2.5.1.183
Glutathione-Requiring Prostaglandin D Synthase2 3     EC 5.3.99.23
Prostaglandin-H2 D-Isomerase2 3     H-PGDS3
GSTS2 3     PTGDS23
GST Class-Sigma2 3     Glutathione S-Transferase3
GSTS1-12     

External Ids:    HGNC: 178901   Entrez Gene: 273062   Ensembl: ENSG000001631067   OMIM: 6025985   UniProtKB: O607603   

Export aliases for HPGDS gene to outside databases

Previous GC identifers: GC04M095439 GC04M090957


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HPGDS Gene:
Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the
conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells.
The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes. (provided
by RefSeq, Jul 2008)

GeneCards Summary for HPGDS Gene: 
HPGDS (hematopoietic prostaglandin D synthase) is a protein-coding gene. Diseases associated with HPGDS include intestinal volvulus, and breast cancer susceptibility, and among its related super-pathways are Prostaglandin 2 biosynthesis and metabolism FM and Metabolic pathways. GO annotations related to this gene include magnesium ion binding and calcium ion binding. An important paralog of this gene is GSTA2.

UniProtKB/Swiss-Prot: HPGDS_HUMAN, O60760
Function: Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in
smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of
glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low
glutathione-peroxidase activity towards cumene hydroperoxide

Gene Wiki entry for HPGDS (PGDS) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for HPGDS
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHPGDS promoter sequence
   Search SABiosciences Chromatin IP Primers for HPGDS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HPGDS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q22.3   Ensembl cytogenetic band:  4q22.3   HGNC cytogenetic band: 4q22.2

HPGDS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HPGDS gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M095219:  view genomic region     (about GC identifiers)

Start:
95,219,686 bp from pter      End:
95,264,027 bp from pter
Size:
44,342 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HPGDS_HUMAN, O60760 (See protein sequence)
Recommended Name: Hematopoietic prostaglandin D synthase  
Size: 199 amino acids; 23344 Da
Cofactor: Glutathione. Required for the prostaglandin D synthase activity
Subunit: Homodimer
Subcellular location: Cytoplasm
Developmental stage: Highest levels in immature megakaryocytic cells. Disappears after final differentiation to
platelets
6/18 PDB 3D structures from and Proteopedia for HPGDS (see all 18):
1IYH (3D)        1IYI (3D)        1V40 (3D)        2CVD (3D)        2VCQ (3D)        2VCW (3D)    
Secondary accessions: Q6FHT9

Explore the universe of human proteins at neXtProt for HPGDS: NX_O60760

Explore proteomics data for HPGDS at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O60760

  • HPGDS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HPGDS Protein Expression
    REFSEQ proteins: NP_055300.1  
    ENSEMBL proteins: 
     ENSP00000295256  
    Reactome Protein details: O60760
    Human Recombinant Protein Products for HPGDS: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for HPGDS (Hematopoietic Prostaglandin D Synthase/HPGDS)
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    Novus Biologicals HPGDS Proteins
    Novus Biologicals HPGDS Lysates
    Sino Biological Recombinant Protein for HPGDS
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for HPGDS
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    HPGDS for ontologies           About GeneDecksing



    HPGDS Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for HPGDS 

    Assay Products for HPGDS: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SGST: Glutathione S-transferases / Soluble

    IUPHAR Guide to PHARMACOLOGY protein family classification: H-PGDS 
    Prostaglandin synthases

    5 InterPro protein domains:
     IPR012336 Thioredoxin-like_fold
     IPR004046 GST_C
     IPR017933 Glutathione_S_Trfase/Cl_chnl_C
     IPR004045 Glutathione_S-Trfase_N
     IPR010987 Glutathione-S-Trfase_C-like

    Graphical View of Domain Structure for InterPro Entry O60760

    ProtoNet protein and cluster: O60760

    1 Blocks protein domain: IPB004045 Glutathione S-transferase

    UniProtKB/Swiss-Prot: HPGDS_HUMAN, O60760
    Similarity: Belongs to the GST superfamily. Sigma family
    Similarity: Contains 1 GST C-terminal domain
    Similarity: Contains 1 GST N-terminal domain


    HPGDS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HPGDS_HUMAN, O60760
    Function: Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in
    smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of
    glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low
    glutathione-peroxidase activity towards cumene hydroperoxide
    Catalytic activity: (5Z,13E,15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate =
    (5Z,13E,15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
    Catalytic activity: RX + glutathione = HX + R-S-glutathione
    Enzyme regulation: Prostaglandin PGD2 synthesis is stimulated by calcium and magnesium ions. One calcium or
    magnesium ion is bound between the subunits of the homodimer. The interactions with the protein are for the most
    part mediated via water molecules. Magnesium increases the affinity for glutathione, while calcium has no effect
    on the affinity for glutathione
    Biophysicochemical properties: Kinetic parameters: KM=8 mM for glutathione for the glutathione-conjugating
    activity; KM=0.6 mM for glutathione for the prostaglandin D synthase activity in the presence of EDTA; KM=0.14 mM
    for glutathione for the prostaglandin D synthase activity in the presence of magnesium ions; Vmax=8.6 umol/min/mg
    enzyme with 1-bromo-2,4-dinitrobenzene as substrate; Vmax=5.1 umol/min/mg enzyme with 1-chloro-2,4-dinitrobenzene
    as substrate; Vmax=44.3 umol/min/mg enzyme with 1-fluoro-2,4-dinitrobenzene as substrate; Vmax=10.7 umol/min/mg
    enzyme with 1-iodo-2,4-dinitrobenzene as substrate; Vmax=6.8 umol/min/mg enzyme with allyl isothiocyanate as
    substrate; Vmax=6.3 umol/min/mg enzyme with benzyl isothiocyanate as substrate; Vmax=0.05 umol/min/mg enzyme with
    cumene hydroperoxide as substrate;
    Induction: By 12-O-tetradecanoylphorbol-13-acetate (TPA)

         Enzyme Numbers (IUBMB): EC 2.5.1.181 EC 5.3.99.21

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA12627223
    GO:0004364glutathione transferase activity IEA--
    GO:0004667prostaglandin-D synthase activity IDA12627223
    GO:0005509calcium ion binding IDA12627223
    GO:0005515protein binding ----
         
    HPGDS for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HPGDS:
     Decreased G3BP1 protein expres 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hpgds):
     behavior/neurological  cellular  immune system  integument  mortality/aging 
     nervous system  tumorigenesis 

    HPGDS for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Hpgdstm1Urad for HPGDS

       inGenious Targeting Laboratory - Custom generated mouse model solutions for HPGDS 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HPGDS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HPGDS 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HPGDS 

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate HPGDS:
    hsa-miR-491-3p
    SwitchGear 3'UTR luciferase reporter plasmidHPGDS 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HPGDS About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
    Synthesis of Prostaglandins (PG) and Thromboxanes (TX)0.42
    C20 prostanoid biosynthesis0.40
    Prostaglandin 2 biosynthesis and metabolism FM0.42
    2Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40
    3Arachidonic acid metabolism
    Arachidonic acid metabolism0.44
    Arachidonic acid metabolism0.44
    4Biological oxidations
    Biological oxidations0.55
    Phase II conjugation0.55
    5Glutathione metabolism
    Glutathione conjugation0.60

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for HPGDS
        Prostaglandin 2 biosynthesis and metabolism FM


    1 GeneGo (Thomson Reuters) Pathway for HPGDS
        Prostaglandin 2 biosynthesis and metabolism FM

    2 BioSystems Pathways for HPGDS
        C20 prostanoid biosynthesis
    Integrated Pancreatic Cancer Pathway


    5/7        Reactome Pathways for HPGDS (see all 7)
        Metabolism
    Arachidonic acid metabolism
    Biological oxidations
    Glutathione conjugation
    Phase II conjugation

    1 PharmGKB Pathway for HPGDS
        Celecoxib Pathway, Pharmacodynamics

    2         Kegg Pathways  (Kegg details for HPGDS):
        Arachidonic acid metabolism
    Metabolic pathways


    HPGDS for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HPGDS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/14 Interacting proteins for HPGDS (O607603 ENSP000002952564) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HK3P527903, ENSP000002924324I2D: score=2 STRING: ENSP00000292432
    AKR1C3ENSP000003699274STRING: ENSP00000369927
    PTGESENSP000003423854STRING: ENSP00000342385
    PTGES2ENSP000003453414STRING: ENSP00000345341
    PTGISENSP000002440434STRING: ENSP00000244043
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006693prostaglandin metabolic process IDA12627223
    GO:0006805xenobiotic metabolic process TAS--
    GO:0007165signal transduction NAS9353279
    GO:0007626locomotory behavior TAS10781097
    GO:0019369arachidonic acid metabolic process TAS--

    HPGDS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HPGDS

    3 HMDB Compounds for HPGDS    About this table
    CompoundSynonyms CAS #PubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Prostaglandin D2prostaglandin d2 (see all 22)41598-07-6--
    Prostaglandin H2Prostaglandin-H2 (see all 27)42935-17-1--

    10/11 DrugBank Compounds for HPGDS (see all 11)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 5)70-18-8target--16547010 8415655 17139284 17016423 15113825 10592235
    2-(2f-Benzothiazolyl)-5-Styryl-3-(4f-Phthalhydrazidyl)Tetrazolium Chloride-- --target--17139284 17016423
    Glycerol-- --target--17139284 17016423
    1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID-- --target--10592235
    2-{[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino}benzoic acid-- --target--10592235
    3-(4-nitrophenyl)-1H-pyrazole-- --target--10592235
    3-phenyl-5-(1H-pyrazol-3-yl)isoxazole-- --target--10592235
    4-(BENZHYDRYLOXY)-1-[3-(1H-TETRAAZOL-5-YL)PROPYL]PIPERIDINE-- --target--10592235
    4-{[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino}-2-hydroxybenzoic acid-- --target--10592235
    PHENYL-5-(1H-PYRAZOL-3-YL)-1,3-THIAZOLE-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about HPGDS

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HPGDS gene: 
    NM_014485.2  

    Unigene Cluster for HPGDS:

    Hematopoietic prostaglandin D synthase
    Hs.128433  [show with all ESTs]
    Unigene Representative Sequence: NM_014485
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295256(uc003hte.1) ENST00000514774 ENST00000506331
    miRNA
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    Additional mRNA sequence: 

    AK290075.1 BC020734.1 CR541662.1 CR541679.1 D82073.1 

    1 DOTS entry:

    DT.104108 

    24/37 AceView cDNA sequences (see all 37):

    AI378572 AA975424 BF593044 AW082637 BG189654 AL550785 AL545369 CB989915 
    BX358964 BG285251 D82073 CR622166 AI206447 BX380262 AI695266 BG191182 
    NM_014485 BG199903 AL574552 CR619711 AL571121 BG620473 CR541679 BC020734 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HPGDS expression in normal human tissues (normalized intensities)      HPGDS embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCCCTCCCC
    HPGDS Expression
    About this image


    HPGDS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
             brain/midbrain   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Umbilical cord blood-derived hematopoietic stem cells
             bone marrow-derived macrophages   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Eye (Sensory Organs)
             Retina
     
     Lower Urinary Tract (Urinary System)
             visceral organ   

    See HPGDS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HPGDS

    SOURCE GeneReport for Unigene cluster: Hs.128433

    UniProtKB/Swiss-Prot: HPGDS_HUMAN, O60760
    Tissue specificity: Expressed in a number of megakaryocytic cell lines but not in platelets. Highly expressed in
    adipose tissue, macrophages and placenta. Also expressed at lower levels in lung, heart, lymph nodes, appendix,
    bone marrow and fetal liver

        SABiosciences Custom PCR Arrays for HPGDS
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HPGDS gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hpgds1 , 5 hematopoietic prostaglandin D synthase1, 5 82.24(n)1
    80.4(a)1
      6 (30.11 cM)5
    544861  NM_019455.41  NP_062328.31 
     651172935 
    chicken
    (Gallus gallus)
    Aves HPGDS1 hematopoietic prostaglandin D synthase 69.35(n)
    66.33(a)
      395863  NM_205011.1  NP_990342.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta GstS11 Glutathione S transferase S1 48.11(n)
    38.66(a)
      36927  NM_079043.2  NP_523767.2 
    worm
    (Caenorhabditis elegans)
    Secernentea gst-51 Protein GST-5 45.96(n)
    41.05(a)
      187537  NM_063956.4  NP_496357.1 


    ENSEMBL Gene Tree for HPGDS (if available)
    TreeFam Gene Tree for HPGDS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HPGDS gene
    GSTA22  GSTA42  GSTA52  GSTA32  GSTA12  

    HPGDS for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1112 SNPs in HPGDS are shown (see all 1112)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs344323851,2
    C,F--90966061(+) ACTATA/-AAACA 1 -- int13Minor allele frequency- -:0.33NA CSA 6
    rs3745375581,2
    C--90981144(+) TTTTT-/GTGTGT 1 -- int10--------
    rs2021283881,2
    --90995131(+) AAAAA-/AAAG  
            
    AAAGA
    1 -- int10--------
    rs76597561,2
    C--90999266(+) tctttC/Ttcttt 1 -- int10--------
    rs1427666781,2
    C--90999268(+) TTTCT-/CTTTTT 1 -- int10--------
    rs1493376391,2
    --95022332(+) TCTGAC/TACCCT 1 -- ds50010--------
    rs1454791611,2
    --95022630(+) CTGGGC/TGGTCT 1 -- ds50010--------
    rs1876386691,2
    --95022761(+) GTGAAA/GAGACC 1 -- ds50010--------
    rs19062381,2
    H--95022895(-) catgtA/Gtctga 1 -- ut31 ese36Minor allele frequency- G:0.00NS EA NA 422
    rs131329631,2
    C,F,A--95022905(+) gttttA/Gcaagt 1 -- ut3110Minor allele frequency- G:0.46NA WA CSA EA 372

    HapMap Linkage Disequilibrium report for HPGDS (95219686 - 95264027 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HPGDS: --
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for HPGDS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602598    OMIM disorders: --

    9 diseases for HPGDS:    About MalaCards
    intestinal volvulus    breast cancer susceptibility    endometriosis    infertility
    asthma    breast cancer    pancreatic cancer    colorectal cancer
    pancreatitis

    2 diseases from the University of Copenhagen DISEASES database for HPGDS:
    Cancer     Malaria

    HPGDS for disorders           About GeneDecksing

    Genetic Association Database (GAD): HPGDS
    Human Genome Epidemiology (HuGE) Navigator: HPGDS (0 documents)

    Export disorders for HPGDS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HPGDS gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with HPGDS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mammalian class Sigma glutathione S-transferases: catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D2 synthases. (PubMed id 11672424)1, 2, 3, 9 Jowsey I.R....Hayes J.D. (2001)
    2. First determination of the inhibitor complex structure of human hematopoietic prostaglandin D synthase. (PubMed id 15113825)1, 2, 7 Inoue T....Urade Y. (2004)
    3. Prostaglandin D synthase in human megakaryoblastic cells. (PubMed id 9353279)1, 2, 3 Mahmud I.... Hayaishi O. (1997)
    4. Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase. (PubMed id 10824118)1, 2, 9 Kanaoka Y....Hayaishi O. (2000)
    5. Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. (PubMed id 16547010)2, 7 Aritake K.... Urade Y. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Mechanism of metal activation of human hematopoietic prostaglandin D synthase. (PubMed id 12627223)1, 2 Inoue T....Urade Y. (2003)
    8. Induction of hematopoietic prostaglandin D synthase in human megakaryocytic cells by phorbol ester. (PubMed id 9425264)1, 2 Suzuki T.... Hayaishi O. (1997)
    9. Novel prostaglandin D synthase inhibitors generated b y fragment-based drug design. (PubMed id 18341273)2, 9 Hohwy M....Edman K. (2008)
    10. Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase. (PubMed id 19939518)2, 9 Weber J.E....Flanagan J.U. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27306 HGNC: 17890 AceView: PGDS Ensembl:ENSG00000163106 euGenes: HUgn27306
    ECgene: HPGDS Kegg: 27306 H-InvDB: HPGDS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HPGDS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HPGDS gene:
    Search GeneIP for patents involving HPGDS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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