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Aliases for HPGD Gene

Aliases for HPGD Gene

  • Hydroxyprostaglandin Dehydrogenase 15-(NAD) 2 3
  • PGDH1 3 4 6
  • Short Chain Dehydrogenase/Reductase Family 36C Member 1 3 4
  • Prostaglandin Dehydrogenase 1 3 4
  • EC 1.1.1.141 4 63
  • 15-PGDH 3 4
  • SDR36C1 3 4
  • PHOAR1 3 6
  • Short Chain Dehydrogenase/Reductase Family 36C, Member 1 3
  • NAD+-Dependent 15-Hydroxyprostaglandin Dehydrogenase 3
  • Short Chain Dehydrogenase/Reductase Family 36C 2
  • 15-Hydroxyprostaglandin Dehydrogenase [NAD(+)] 3
  • Member 1 2
  • EC 1.1.1 63
  • PGDH 3

External Ids for HPGD Gene

Previous GeneCards Identifiers for HPGD Gene

  • GC04M176331
  • GC04M175949
  • GC04M176107
  • GC04M175786
  • GC04M175647
  • GC04M175411
  • GC04M171160

Summaries for HPGD Gene

Entrez Gene Summary for HPGD Gene

  • This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

GeneCards Summary for HPGD Gene

HPGD (Hydroxyprostaglandin Dehydrogenase 15-(NAD)) is a Protein Coding gene. Diseases associated with HPGD include digital clubbing, isolated congenital and cranioosteoarthropathy. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include protein homodimerization activity and NAD+ binding. An important paralog of this gene is DECR2.

UniProtKB/Swiss-Prot for HPGD Gene

  • Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells.

Gene Wiki entry for HPGD Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HPGD Gene

Genomics for HPGD Gene

Regulatory Elements for HPGD Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HPGD Gene

Start:
174,490,177 bp from pter
End:
174,523,154 bp from pter
Size:
32,978 bases
Orientation:
Minus strand

Genomic View for HPGD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HPGD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HPGD Gene

Proteins for HPGD Gene

  • Protein details for HPGD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15428-PGDH_HUMAN
    Recommended name:
    15-hydroxyprostaglandin dehydrogenase [NAD(+)]
    Protein Accession:
    P15428
    Secondary Accessions:
    • B4DTA4
    • B4DU74
    • B4DV57
    • D3DP43
    • E7EV11
    • O00749
    • Q06F08
    • Q12998

    Protein attributes for HPGD Gene

    Size:
    266 amino acids
    Molecular mass:
    28977 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for HPGD Gene

    Alternative splice isoforms for HPGD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HPGD Gene

Proteomics data for HPGD Gene at MOPED

Selected DME Specific Peptides for HPGD Gene

Post-translational modifications for HPGD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains for HPGD Gene

Gene Families for HPGD Gene

HGNC:
  • SDRC1 :Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 1
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

P15428

UniProtKB/Swiss-Prot:

PGDH_HUMAN :
  • P15428
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with HPGD: view

Function for HPGD Gene

Molecular function for HPGD Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=3.4 uM for prostaglandin E2 {ECO:0000269 PubMed:16828555}; KM=38 uM for NAD {ECO:0000269 PubMed:16828555};
UniProtKB/Swiss-Prot CatalyticActivity:
(5Z,13E,15S)-11-alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD(+) = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH
UniProtKB/Swiss-Prot Function:
Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells.
UniProtKB/Swiss-Prot Induction:
Down-regulated by cortisol, dexamethasone and betamethasone. Down-regulated in colon cancer. Up-regulated by TGFB1.

Enzyme Numbers (IUBMB) for HPGD Gene

Gene Ontology (GO) - Molecular Function for HPGD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IDA 2025296
GO:0004957 prostaglandin E receptor activity IDA 10198228
GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity TAS --
GO:0016491 oxidoreductase activity --
GO:0042803 protein homodimerization activity TAS 2025296
genes like me logo Genes that share ontologies with HPGD: view
genes like me logo Genes that share phenotypes with HPGD: view

Animal Models for HPGD Gene

MGI Knock Outs for HPGD:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HPGD

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for HPGD Gene

Localization for HPGD Gene

Subcellular locations from UniProtKB/Swiss-Prot for HPGD Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HPGD Gene COMPARTMENTS Subcellular localization image for HPGD gene
Compartment Confidence
cytosol 5
nucleus 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HPGD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0016323 basolateral plasma membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with HPGD: view

Pathways for HPGD Gene

genes like me logo Genes that share pathways with HPGD: view

Pathways by source for HPGD Gene

Interacting Proteins for HPGD Gene

Gene Ontology (GO) - Biological Process for HPGD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006693 prostaglandin metabolic process IDA 16828555
GO:0007179 transforming growth factor beta receptor signaling pathway IDA 15574495
GO:0007565 female pregnancy IDA 15531523
GO:0007567 parturition IDA 15531523
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with HPGD: view

Compounds for HPGD Gene

(11) HMDB Compounds for HPGD Gene

Compound Synonyms Cas Number PubMed IDs
12S-HHT
  • 12(S)-hydroxy-(5Z,8Z,10E)-heptadeca-5,8,10-trienoic acid anion
54397-84-1
13,14-Dihydro- lipoxin A4
  • 13,14-dihydro-LXA(,4)
Not Available
13,14-Dihydro-15-oxo-lipoxin A4
  • 13,14-dihydro-15-oxo-LXA(,4)
Not Available
15-Keto-prostaglandin F2a
  • 15-Keto-PGF2a
35850-13-6
15-Oxo-lipoxin A4
  • 15-oxo-LXA(,4)
Not Available

(1) Drugbank Compounds for HPGD Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
NADH
  • beta-DPNH
606-68-8 target

(39) Novoseek inferred chemical compound relationships for HPGD Gene

Compound -log(P) Hits PubMed IDs
prostaglandin 84.8 56
13,14-dihydro-15-keto-pge2 82 4
pge2 77.7 59
13,14-dihydro-15-ketoprostaglandin f2alpha 74.7 3
nad+ 69.8 30
genes like me logo Genes that share compounds with HPGD: view

Transcripts for HPGD Gene

Unigene Clusters for HPGD Gene

Hydroxyprostaglandin dehydrogenase 15-(NAD):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HPGD

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HPGD Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - -
SP2: -
SP3: - - - - - -
SP4: - - -
SP5: - - -
SP6: -

Relevant External Links for HPGD Gene

GeneLoc Exon Structure for
HPGD
ECgene alternative splicing isoforms for
HPGD

Expression for HPGD Gene

mRNA expression in normal human tissues for HPGD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HPGD Gene

This gene is overexpressed in Bladder (5.1), Vagina (4.9), Whole Blood (4.8), Liver (4.5), and Esophagus - Mucosa (4.3).

Protein differential expression in normal tissues for HPGD Gene

This gene is overexpressed in Lung (14.4), Placenta (8.9), Cardia (8.3), and Stomach (8.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HPGD Gene

SOURCE GeneReport for Unigene cluster for HPGD Gene Hs.596913

mRNA Expression by UniProt/SwissProt for HPGD Gene

P15428-PGDH_HUMAN
Tissue specificity: Detected in colon epithelium (at protein level).
genes like me logo Genes that share expressions with HPGD: view

In Situ Assay Products

No data available for Expression partners for HPGD Gene

Orthologs for HPGD Gene

This gene was present in the common ancestor of animals.

Orthologs for HPGD Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HPGD 35
  • 90.23 (n)
  • 93.23 (a)
HPGD 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HPGD 35
  • 92.36 (n)
  • 94.36 (a)
HPGD 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hpgd 35
  • 88.13 (n)
  • 89.77 (a)
Hpgd 16
Hpgd 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HPGD 35
  • 99.87 (n)
  • 100 (a)
HPGD 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hpgd 35
  • 87.88 (n)
  • 89.02 (a)
oppossum
(Monodelphis domestica)
Mammalia HPGD 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 82 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
chicken
(Gallus gallus)
Aves HPGD 35
  • 75.13 (n)
  • 73.48 (a)
HPGD 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HPGD 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hpgd 35
  • 69.79 (n)
  • 71.09 (a)
Str.8168 35
zebrafish
(Danio rerio)
Actinopterygii LOC565975 35
  • 62.84 (n)
  • 57.09 (a)
CU928070.1 36
  • 57 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6946 35
fruit fly
(Drosophila melanogaster)
Insecta CG4842 37
  • 36 (a)
Pdh 37
  • 36 (a)
Adh 36
  • 23 (a)
OneToMany
Adhr 36
  • 24 (a)
OneToMany
CG18814 36
  • 27 (a)
OneToMany
CG4842 36
  • 28 (a)
OneToMany
Fbp2 36
  • 25 (a)
OneToMany
Pdh 36
  • 29 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001753 35
  • 49.18 (n)
  • 39.89 (a)
Species with no ortholog for HPGD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HPGD Gene

ENSEMBL:
Gene Tree for HPGD (if available)
TreeFam:
Gene Tree for HPGD (if available)

Paralogs for HPGD Gene

Selected SIMAP similar genes for HPGD Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with HPGD: view

Variants for HPGD Gene

Sequence variations from dbSNP and Humsavar for HPGD Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs8752 -- 174,491,326(-) GTTCA(A/G)CCTCC utr-variant-3-prime
rs1050143 -- 174,522,013(-) CCCTG(C/G)ATGAG missense, reference, utr-variant-5-prime
rs1050145 -- 174,522,005(-) GAGCA(A/G)TTTGA synonymous-codon, reference, utr-variant-5-prime
rs1346270 -- 174,522,904(-) GCAAC(A/G)AGTTT upstream-variant-2KB
rs1346271 -- 174,522,855(-) GGGAG(C/G)GAGTG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for HPGD Gene

Variant ID Type Subtype PubMed ID
nsv525487 CNV Gain 19592680
nsv881299 CNV Loss 21882294
nsv509946 CNV Loss 20534489
nsv880289 CNV Gain 21882294
nsv881270 CNV Loss 21882294
nsv880970 CNV Loss 21882294
nsv880884 CNV Loss 21882294

Relevant External Links for HPGD Gene

HapMap Linkage Disequilibrium report
HPGD
Human Gene Mutation Database (HGMD)
HPGD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HPGD Gene

Disorders for HPGD Gene

(2) OMIM Diseases for HPGD Gene (601688)

UniProtKB/Swiss-Prot

PGDH_HUMAN
  • Hypertrophic osteoarthropathy, primary, autosomal recessive, 1 (PHOAR1) [MIM:259100]: A disease characterized by digital clubbing, periostosis, acroosteolysis, painful joint enlargement, and variable features of pachydermia that include thickened facial skin and a thickened scalp. Other developmental anomalies include delayed closure of the cranial sutures and congenital heart disease. {ECO:0000269 PubMed:18500342}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Cranioosteoarthropathy (COA) [MIM:259100]: A form of osteoarthropathy characterized by swelling of the joints, digital clubbing, hyperhidrosis, delayed closure of the fontanels, periostosis, and variable patent ductus arteriosus. Pachydermia is not a prominent feature. {ECO:0000269 PubMed:18500342}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Isolated congenital nail clubbing (ICNC) [MIM:119900]: A rare genodermatosis characterized by enlargement of the nail plate and terminal segments of the fingers and toes, resulting from proliferation of the connective tissues between the nail matrix and the distal phalanx. It is usually symmetrical and bilateral (in some cases unilateral). In nail clubbing usually the distal end of the nail matrix is relatively high compared to the proximal end, while the nail plate is complete but its dimensions and diameter more or less vary in comparison to normal. There may be different fingers and toes involved to varying degrees. Some fingers or toes are spared, but the thumbs are almost always involved. {ECO:0000269 PubMed:18805827}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for HPGD Gene

(21) Novoseek inferred disease relationships for HPGD Gene

Disease -log(P) Hits PubMed IDs
pachydermoperiostosis 59.6 5
chorioamnionitis 46.2 2
colon cancer 44.7 17
colon tumor 39.1 4
adenocarcinoma lung 37 4

Relevant External Links for HPGD

Genetic Association Database (GAD)
HPGD
Human Genome Epidemiology (HuGE) Navigator
HPGD
genes like me logo Genes that share disorders with HPGD: view

No data available for Genatlas for HPGD Gene

Publications for HPGD Gene

  1. Site-directed mutagenesis of the conserved tyrosine 151 of human placental NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase yields a catalytically inactive enzyme. (PMID: 2025296) Ensor C.M. … Tai H.-H. (Biochem. Biophys. Res. Commun. 1991) 3 4 23
  2. Mechanism of cortisol/progesterone antagonism in the regulation of 15-hydroxyprostaglandin dehydrogenase activity and messenger ribonucleic acid levels in human chorion and placental trophoblast cells at term. (PMID: 12788907) Patel F.A. … Challis J.R.G. (J. Clin. Endocrinol. Metab. 2003) 3 4 23
  3. 15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers. (PMID: 15574495) Yan M. … Markowitz S.D. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 23
  4. Role of glutamine 148 of human 15-hydroxyprostaglandin dehydrogenase in catalytic oxidation of prostaglandin E2. (PMID: 16828555) Cho H. … Tai H.-H. (Bioorg. Med. Chem. 2006) 3 4 23
  5. Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy. (PMID: 18500342) Uppal S. … Bonthron D.T. (Nat. Genet. 2008) 3 4 23

Products for HPGD Gene

  • Addgene plasmids for HPGD

Sources for HPGD Gene

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