Aliases for HPGD Gene
External Ids for HPGD Gene
Previous GeneCards Identifiers for HPGD Gene
This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
GeneCards Summary for HPGD Gene
HPGD (Hydroxyprostaglandin Dehydrogenase 15-(NAD)) is a Protein Coding gene. Diseases associated with HPGD include Cranioosteoarthropathy and Digital Clubbing, Isolated Congenital. Among its related pathways are Arachidonic acid metabolism and Transcriptional misregulation in cancer. GO annotations related to this gene include protein homodimerization activity and NAD binding. An important paralog of this gene is HSD17B10.
UniProtKB/Swiss-Prot for HPGD Gene
Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells.