Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HPGD Gene

protein-coding GIFtS: 72
GCID: GC04M175411

Hydroxyprostaglandin Dehydrogenase 15-(NAD)

Microbiology & Infectious Diseases Congress

34 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Hydroxyprostaglandin Dehydrogenase 15-(NAD)¹ ²		15-Hydroxyprostaglandin Dehydrogenase [NAD(+)]²
PGDH1² ³ ⁵		PGDH²
Prostaglandin Dehydrogenase 1² ³		PHOAR1²
15-PGDH² ³		SDR36C1²
EC 1.1.1.141³ ⁸		NAD+-Dependent 15-Hydroxyprostaglandin Dehydrogenase²
Member 1¹		Short Chain Dehydrogenase/Reductase Family 36C, Member 1²
Short Chain Dehydrogenase/Reductase Family 36C¹		EC 1.1.1⁸

External Ids:	HGNC: 5154¹	Entrez Gene: 3248²	Ensembl: ENSG00000164120⁷	OMIM: 601688⁵	UniProtKB: P15428³

ORGUL members:
	NONCODE¹⁴:n407800

Export aliases for HPGD gene to outside databases

Previous GC identifers: GC04M176331 GC04M175949 GC04M176107 GC04M175786 GC04M175647 GC04M171160

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HPGD Gene:

This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme

is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes

such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and

cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene.

(provided by RefSeq, Mar 2009)

GeneCards Summary for HPGD Gene:

HPGD (hydroxyprostaglandin dehydrogenase 15-(NAD)) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with HPGD include primary hypertrophic osteoarthropathy, and isolated congenital digital clubbing, and among its related super-pathways are Prostaglandin 2 biosynthesis and metabolism FM and Metabolic pathways. GO annotations related to this gene include NAD binding and protein homodimerization activity. An important paralog of this gene is DCXR.

UniProtKB/Swiss-Prot: PGDH_HUMAN, P15428

Function: Prostaglandin inactivation. Contributes to the regulation of events that are under the control of

prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in

vivo proliferation of colon cancer cells

Gene Wiki entry for HPGD Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.2 NT_016354.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HPGD gene promoter:
RFX1 LHX3b/Lhx3b POU3F1 POU3F2 FOXO3b AREB6 FOXO3a STAT3 LHX3a/Lhx3a RSRFC4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HPGD promoter sequence

Search SABiosciences Chromatin IP Primers for HPGD

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HPGD

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q34-q35 Ensembl cytogenetic band: 4q34.1 HGNC cytogenetic band: 4q34-q35

HPGD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HPGD gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M175411: view genomic region (about GC identifiers)

Start:	175,411,328 bp from pter	End:	175,444,305 bp from pter
Size:	32,978 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PGDH_HUMAN, P15428 (See protein sequence)

Recommended Name: 15-hydroxyprostaglandin dehydrogenase [NAD(+)]

Size: 266 amino acids; 28977 Da

Subunit: Homodimer

Subcellular location: Cytoplasm

1 PDB 3D structure from and Proteopedia for HPGD:

2GDZ (3D)

Secondary accessions: B4DTA4 B4DU74 B4DV57 D3DP43 E7EV11 O00749 Q06F08

Alternative splicing: 5 isoforms: P15428-1 P15428-2 P15428-3 P15428-4 P15428-5 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HPGD: NX_P15428

Explore proteomics data for HPGD at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_P15428

4/7 DME Specific Peptides for HPGD (P15428) (see all 7)

KVALVTG

LMNSGVR

QCDVADQ

SIEKEENMG

HPGD Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (6 alternative transcripts):

NP_000851.2 NP_001139288.1 NP_001243230.1 NP_001243234.1 NP_001243235.1 NP_001243236.1

ENSEMBL proteins:

ENSP00000296522 ENSP00000427699 ENSP00000296521 ENSP00000422418 ENSP00000398720

ENSP00000425741 ENSP00000423066 ENSP00000423110 ENSP00000420892 ENSP00000438017

ENSP00000443644

Reactome Protein details: P15428
Human Recombinant Protein Products for HPGD:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for HPGD (15-PGDH/HPGD)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for HPGD OriGene Protein Over-expression Lysate for HPGD OriGene MassSpec for HPGD OriGene Custom Protein Services for HPGD
	GenScript Custom Purified and Recombinant Proteins Services for HPGD
	Novus Biologicals HPGD Proteins Novus Biologicals HPGD Lysates
	Sino Biological Recombinant Protein for HPGD Browse Sino Biological Cell Lysates
	ProSpec Recombinant Protein for HPGD
	Cloud-Clone Corp. Proteins for HPGD

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005829	cytosol	TAS	--

HPGD for ontologies About GeneDecksing

HPGD Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for HPGD (15-PGDH/HPGD)
	OriGene Antibodies for HPGD OriGene Custom Antibody Services for HPGD
	GenScript Custom Superior Antibodies Services for HPGD
	Novus Biologicals HPGD Antibodies
	Abcam antibodies for HPGD
	Cloud-Clone Corp. Antibodies for HPGD
	ThermoFisher Antibody for HPGD
	LSBio Antibodies in human, mouse, rat for HPGD

Assay Products for HPGD:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for HPGD
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for HPGD
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for HPGD Cloud-Clone Corp. CLIAs for HPGD

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

SDRC1: Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 1

IUPHAR Guide to PHARMACOLOGY protein family classification: HPGD

Prostaglandin synthases

4 InterPro protein domains:

IPR020904 Sc_DH/Rdtase_CS

IPR002347 Glc/ribitol_DH

IPR002198 DH_sc/Rdtase_SDR

IPR016040 NAD(P)-bd_dom

Graphical View of Domain Structure for InterPro Entry P15428

ProtoNet protein and cluster: P15428

2 Blocks protein domains:

IPB002198 Short-chain dehydrogenase/reductase SDR

IPB002347 Glucose/ribitol dehydrogenase family signature

UniProtKB/Swiss-Prot: PGDH_HUMAN, P15428

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family

HPGD for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PGDH_HUMAN, P15428

Function: Prostaglandin inactivation. Contributes to the regulation of events that are under the control of

prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in

vivo proliferation of colon cancer cells

Catalytic activity: (5Z,13E,15S)-11-alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD(+) =

(5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH

Biophysicochemical properties: Kinetic parameters: KM=3.4 uM for prostaglandin E2; KM=38 uM for NAD;

Induction: Down-regulated by cortisol, dexamethasone and betamethasone. Down-regulated in colon cancer. Up-regulated by

TGFB1

Enzyme Numbers (IUBMB): EC 1.1.1.141¹ ² EC 1.1.1²

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003824	catalytic activity	IDA	2025296
GO:0004957	prostaglandin E receptor activity	IDA	10198228
GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity	TAS	--
GO:0016491	oxidoreductase activity	--	--
GO:0042803	protein homodimerization activity	TAS	2025296

HPGD for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for HPGD:

Decreased influenza A H1N1 (A/

Decreased influenza A/WSN/33 r

Increased mitotic index

5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Hpgd):

cardiovascular system

endocrine/exocrine gland

homeostasis/metabolism

mortality/aging

reproductive system

HPGD for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for HPGD: Hpgd^tm1Bhk Hpgd^tm1Ljm

inGenious Targeting Laboratory - Custom generated mouse model solutions for HPGD

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HPGD

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HPGD
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate HPGD (see all 10):
		hsa-miR-4324 hsa-miR-218 hsa-miR-1297 hsa-miR-548t hsa-miR-544b hsa-miR-1252 hsa-miR-26a hsa-miR-378*

		SwitchGear 3'UTR luciferase reporter plasmid: HPGD 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for HPGD
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HPGD
		Sirion Biotech Custom design and validation of potent shRNA sequences against HPGD

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for HPGD
			Sirion Biotech Customized adenovirus for overexpression of HPGD Customized adenovirus for potent knockdown of HPGD

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for HPGD (see all 13) OriGene ORF clones in mouse, rat for HPGD OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): HPGD (NM_000860)
		Sino Biological Human cDNA Clone for HPGD
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HPGD
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HPGD

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HPGD
		Search LifeMap BioReagents cell lines for HPGD
		Sirion Biotech Customized stable knockdown cell line services for HPGD Customized inducible knockdown cell line services for HPGD Customized stable overexpressing cell line services for HPGD Customized inducible overexpressing cell line services for HPGD

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HPGD

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for HPGD About (see all 6)

See pathways by source

SuperPath

Contained pathways About

Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

0.42

Prostaglandin 2 biosynthesis and metabolism FM

0.42

Metabolism

Metabolism

0.40

Metabolism of lipids and lipoproteins

0.34

Arachidonic acid metabolism

Arachidonic acid metabolism

0.44

Synthesis of 15-eicosatetraenoic acid derivatives

Synthesis of Lipoxins (LX)

0.33

Transcriptional misregulation in cancer

Transcriptional misregulation in cancer

Pathways by source See SuperPaths
Show all pathways

1 EMD Millipore Pathway for HPGD

Prostaglandin 2 biosynthesis and metabolism FM

1 GeneGo (Thomson Reuters) Pathway for HPGD

Prostaglandin 2 biosynthesis and metabolism FM

1 BioSystems Pathway for HPGD

Prostaglandin Synthesis and Regulation

5 Reactome Pathways for HPGD

	Synthesis of Lipoxins (LX)
	Metabolism
	Arachidonic acid metabolism
	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
	Metabolism of lipids and lipoproteins

1 Kegg Pathway (Kegg details for HPGD):

Transcriptional misregulation in cancer

HPGD for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for HPGD

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for HPGD (ENSP00000296522⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GBE1	ENSP00000410833⁴	STRING: ENSP00000410833

About this table

Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006693	prostaglandin metabolic process	IDA	16828555
GO:0007179	transforming growth factor beta receptor signaling pathway	IDA	15574495
GO:0007565	female pregnancy	IDA	15531523
GO:0007567	parturition	IDA	15531523
GO:0008152	metabolic process	--	--

HPGD for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

HPGD for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HPGD (PGDH)

10/11 HMDB Compounds for HPGD (see all 11) About this table

Compound	Synonyms	CAS #	PubMed Ids
12S-HHT	12(S)-hydroxy-(5Z,8Z,10E)-heptadeca-5,8,10-trienoic acid anion (see all 11)	54397-84-1	--
13,14-Dihydro- lipoxin A4	13,14-dihydro-LXA(,4) (see all 3)	--	--
13,14-Dihydro-15-oxo-lipoxin A4	13,14-dihydro-15-oxo-LXA(,4) (see all 3)	--	--
15-Keto-prostaglandin F2a	15-Keto-PGF2a (see all 9)	35850-13-6	--
15-Oxo-lipoxin A4	15-oxo-LXA(,4) (see all 3)	--	--
NAD	3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)	53-84-9	--
NADH	1,4-Dihydronicotinamide adenine dinucleotide (see all 17)	58-68-4	--
Prostaglandin E2	(-)-Prostaglandin E2 (see all 22)	363-24-6	--
Prostaglandin E2 ethanolamide	PGE2EA	--	--
Prostaglandin F2a	Protamodin (see all 37)	551-11-1	--

1 DrugBank Compound for HPGD About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
NADH	beta-DPNH (see all 18)	606-68-8	target	--	17463062

10/39 Novoseek inferred chemical compound relationships for HPGD gene (see all 39) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
prostaglandin	84.8	75	15531523 (3), 18639206 (3), 8370712 (2), 19667156 (2) (see all 47)
13,14-dihydro-15-keto-pge2	82	6	19138967 (2), 8370712 (1), 11702189 (1)
pge2	77.7	94	19820419 (4), 18438860 (3), 16828555 (3), 15908215 (2) (see all 39)
13,14-dihydro-15-ketoprostaglandin f2alpha	74.7	4	10599732 (1), 9920098 (1), 10022390 (1)
nad+	69.8	36	11872167 (3), 10198228 (3), 18805827 (2), 19568269 (2) (see all 19)
trilostane	66.3	11	11836308 (4), 12788907 (2), 9920098 (1)
(+-)-pgf2-alpha	64	6	10022390 (1), 17307913 (1), 16514200 (1), 10650939 (1)
onapristone	55.8	2	9920098 (1), 8671154 (1)
ribonucleic acid	51.5	12	18308117 (2), 9920098 (2), 9062515 (2), 10599732 (1)
calcitriol	51.4	8	16886660 (1), 18290727 (1), 11237475 (1), 19667156 (1) (see all 8)

Search CenterWatch for drugs/clinical trials and news about HPGD / PGDH

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HPGD gene (6 alternative transcripts):

NM_000860.5 NM_001145816.2 NM_001256301.1 NM_001256305.1 NM_001256306.1 NM_001256307.1

Unigene Cluster for HPGD:

Hydroxyprostaglandin dehydrogenase 15-(NAD)

Hs.596913 [show with all ESTs]

Unigene Representative Sequence: NM_000860

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000296522(uc003itu.2 uc003itv.2 uc011ckf.1 uc010irq.2 uc011ckg.1 uc011ckh.1)

ENST00000510835 ENST00000296521 ENST00000510901 ENST00000511499 ENST00000422112

ENST00000508330 ENST00000509512 ENST00000506910 ENST00000514584 ENST00000512410

ENST00000504433 ENST00000541923 ENST00000542498

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HPGD
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate HPGD (see all 10):
		hsa-miR-4324 hsa-miR-218 hsa-miR-1297 hsa-miR-548t hsa-miR-544b hsa-miR-1252 hsa-miR-26a hsa-miR-378*

		SwitchGear 3'UTR luciferase reporter plasmid: HPGD 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for HPGD
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HPGD
		Sirion Biotech Custom design and validation of potent shRNA sequences against HPGD

Clone Products:		OriGene clones in human, mouse for HPGD (see all 13) OriGene ORF clones in mouse, rat for HPGD OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): HPGD (NM_000860)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HPGD
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HPGD

Primer Products:		OriGene qPCR primer pairs and template standards for HPGD OriGene qSTAR qPCR primer pairs in human, mouse for HPGD
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HPGD
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HPGD
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HPGD

Additional mRNA sequence:

AK058013.1 AK296642.1 AK300125.1 AK300524.1 AK300940.1 AK314624.1 BC007691.2 BC018986.2

J05594.1 L76465.1 U63296.1 X82460.1

15 DOTS entries:

DT.100826238 DT.455971 DT.100826243 DT.100826235 DT.100849187 DT.97854774 DT.92458230 DT.100826239

DT.100826241 DT.121246202 DT.92458232 DT.95167318 DT.100675907 DT.121246228 DT.92458237

24/321 AceView cDNA sequences (see all 321):

CR603849 BX397652 AU136004 AU138943 AA047485 CR605509 AU137292 CR594801

BF725997 CR603356 AA149207 CR602985 CR590250 CB164778 CA306054 AU134733

BX337355 BX091884 AU135105 AL542647 AU117975 AA036995 CR619023 AU139437

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for HPGD (see all 6) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	^	8a	·	8b	·	8c
SP1:					-								-		-				-
SP2:					-
SP3:					-				-		-		-		-				-
SP4:					-								-		-
SP5:													-		-				-

ECgene alternative splicing isoforms for HPGD

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HPGD expression in normal human tissues (normalized intensities) HPGD embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TGAGATTGAT

About this image

HPGD expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/16 selected tissues (see all 16) fully expand


Kidney (Urinary System) fully expand to see all 10 entries
Loop of Henle Cells Loop of Henle
Proximal Tubule
visceral organ/metanephros/renal medulla

Lower Urinary Tract (Urinary System) fully expand to see all 6 entries
bladder

Bone (Muscoskeletal System) fully expand to see all 3 entries
Zeugopod Growth Plate
HyStem+BMP4-induced MEL2 cells

Placenta (Extraembryonic Tissues)
Primordial germ cell-like cells (Reconstitution of mouse germ cell from pluripotent...

Reproductive System (Reproductive System)
Primordial germ cell-like cells (Reconstitution of mouse germ cell from pluripotent...

See HPGD Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HPGD

SOURCE GeneReport for Unigene cluster: Hs.596913

UniProtKB/Swiss-Prot: PGDH_HUMAN, P15428

Tissue specificity: Detected in colon epithelium (at protein level)

SABiosciences Custom PCR Arrays for HPGD

Primer Products:		OriGene qPCR primer pairs and template standards for HPGD OriGene qSTAR qPCR primer pairs in human, mouse for HPGD
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HPGD
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HPGD
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HPGD

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HPGD

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for HPGD gene from 7/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Hpgd^{1 , 5}	hydroxyprostaglandin dehydrogenase 15 (NAD)^{1, 5}	88.13(n)¹ 89.77(a)¹		8 (29.70 cM)⁵ 15446¹ NM_008278.2¹ NP_032304.2¹ 56294552⁵
chicken (Gallus gallus)	Aves	HPGD¹	hydroxyprostaglandin dehydrogenase 15-(NAD)	75.13(n) 73.48(a)		422567 XM_420526.3 XP_420526.1
lizard (Anolis carolinensis)	Reptilia	HPGD⁶	Uncharacterized protein	61(a)	1 ↔ 1	3(143880941-143909974)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.8168²	Transcribed sequence with moderate similarity to protein more	72.61(n)		CF591688.1
zebrafish (Danio rerio)	Actinopterygii	LOC565975¹	15-hydroxyprostaglandin dehydrogenase [NAD+]-like	63.04(n) 57.2(a)		565975 XM_689239.5 XP_694331.5
fruit fly (Drosophila melanogaster)	Insecta	CG4842³ Pdh¹	oxidoreductase, acting on the CH-OH group of more³ Photoreceptor dehydrogenase¹	36(a) (best of 2)³ 48.24(n)¹ 37.55(a)¹		39812¹ NM_168659.1¹ NP_730153.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	YMR226C⁶	NADP(+)-dependent dehydrogenase; acts on serine, L...	21(a)	1 → many	XIII(721593-722396)

ENSEMBL Gene Tree for HPGD (if available)
TreeFam Gene Tree for HPGD (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HPGD gene

DCXR² DECR2² CBR4² PECR² HSD17B14² DHRS2² HSD17B10² DHRS4²

BDH2² DHRS4L2² HSD17B8² DECR1²

6 SIMAP similar genes for HPGD using alignment to 6 protein entries: PGDH_HUMAN (see all proteins):

PGDH DHRS2 PECR RDH10 BDH2 CBR4

HPGD for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_046209⁴		Cranioosteoarthropathy (COA)⁴	--	see VAR_046209	2	A P	mis⁴		0	--	--	--	--
VAR_060792⁴		Isolated congenital nail clubbing (ICNC)⁴	--	see VAR_060792	2	S P	mis⁴		0	--	--	--	--
VAR_006972⁴		--	--	see VAR_006972	2	Y C	mis⁴		0	--	--	--	--
rs200179921^1,2	C	--	171181464(+)	`TTCAG-/AAAAAAA`	6	--	int¹		0	--	--	--	--
rs112838772^1,2	C	--	171185865(+)	`AAAATAGAC/- AGATG`	6	--	int¹		1		CSA	2
rs111659072^1,2	C	--	171189471(+)	`ATGGA-/T/TT TTTTT`	6	--	int¹		1		CSA	2
rs193182555^1,2		--	175182289(+)	`CCTGGA/GTCCAA`	6	--	ds500¹		0	--	--	--	--
rs17060524^1,2	C,F,H	--	175182404(+)	`TTTGCA/CTTCTC`	6	--	ds500¹		11		NA NS	960
rs45463992^1,2	C,F	--	175182441(-)	`TTTTGC/TTCTCT`	6	--	ds500¹		3		NS NA	210
rs13150727^1,2	H	--	175182658(+)	`TATATA/TCCATT`	6	--	ds500¹		4		NS EA	366

HapMap Linkage Disequilibrium report for HPGD (175411328 - 175444305 bp)

Structural Variations
Database of Genomic Variants (DGV) 7 variations for HPGD: About this table

Variant ID	Type	Subtype	PubMed ID
nsv881270	CNV	Loss	21882294
nsv509946	CNV	Loss	20534489
nsv880884	CNV	Loss	21882294
nsv880970	CNV	Loss	21882294
nsv881299	CNV	Loss	21882294
nsv880289	CNV	Gain	21882294
nsv525487	CNV	Gain	19592680

Human Gene Mutation Database (HGMD): HPGD

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HPGD

DNA2.0 Custom Variant and Variant Library Synthesis for HPGD

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HPGD for disorders           About GeneDecksing

OMIM gene information: 601688
OMIM disorders: 259100  119900
UniProtKB/Swiss-Prot: PGDH_HUMAN, P15428

Hypertrophic osteoarthropathy, primary, autosomal recessive, 1 (PHOAR1) [MIM:259100]: A disease characterized

by digital clubbing, periostosis, acroosteolysis, painful joint enlargement, and variable features of pachydermia that

include thickened facial skin and a thickened scalp. Other developmental anomalies include delayed closure of the

cranial sutures and congenital heart disease. Note=The disease is caused by mutations affecting the gene represented

in this entry

Cranioosteoarthropathy (COA) [MIM:259100]: A form of osteoarthropathy characterized by swelling of the joints,

digital clubbing, hyperhidrosis, delayed closure of the fontanels, periostosis, and variable patent ductus arteriosus.

Pachydermia is not a prominent feature. Note=The disease is caused by mutations affecting the gene represented in this

entry

Isolated congenital nail clubbing (ICNC) [MIM:119900]: A rare genodermatosis characterized by enlargement of

the nail plate and terminal segments of the fingers and toes, resulting from proliferation of the connective tissues

between the nail matrix and the distal phalanx. It is usually symmetrical and bilateral (in some cases unilateral). In

nail clubbing usually the distal end of the nail matrix is relatively high compared to the proximal end, while the

nail plate is complete but its dimensions and diameter more or less vary in comparison to normal. There may be

different fingers and toes involved to varying degrees. Some fingers or toes are spared, but the thumbs are almost

always involved. Note=The disease is caused by mutations affecting the gene represented in this entry

20/34 diseases for HPGD (see all 34): About MalaCards

primary hypertrophic osteoarthropathy isolated congenital digital clubbing apocrine adenocarcinoma primary hypertrophic osteoarthropathy, autosomal recessive

chorioamnionitis patent ductus arteriosus bladder transitional cell carcinoma ureteral obstruction

transitional cell carcinoma bacterial vaginosis lung adenocarcinoma alcoholism

gastric adenocarcinoma colon cancer colorectal cancer peritonitis

adenocarcinoma endometriosis cytochrome p450 osteoarthritis

1 disease from the University of Copenhagen DISEASES database for HPGD:

Primary hypertrophic osteoarthropathy

10/21 Novoseek inferred disease relationships for HPGD gene (see all 21) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pachydermoperiostosis	59.6	4	20406614 (2), 20299379 (2), 19568269 (1)
chorioamnionitis	46.2	4	15970823 (1), 9062515 (1)
colon cancer	44.7	21	15574495 (5), 18593902 (2), 19501039 (2), 19820419 (1) (see all 11)
colon tumor	39.1	4	16880406 (2), 19887544 (1), 11352223 (1)
adenocarcinoma lung	37	4	16844092 (1), 15680906 (1), 16632868 (1), 17481556 (1)
labor premature	32.7	1	17327104 (1)
adenoma	26.9	11	16880406 (2), 19470469 (2), 15542609 (1), 20086108 (1)
bladder tumors	26.1	1	12954496 (1)
tumors	25.1	63	15358636 (5), 16885386 (4), 17481556 (4), 18593902 (3) (see all 28)
nsclc	24.9	13	19138967 (7), 17575121 (3), 15358636 (1)

Genetic Association Database (GAD): HPGD
Human Genome Epidemiology (HuGE) Navigator: HPGD (12 documents)

Export disorders for HPGD gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for HPGD gene, integrated from 9 sources (see all 193):
(articles sorted by number of sources associating them with HPGD)

Utopia: connect your pdf to the dynamic
world of online information

Mechanism of cortisol/progesterone antagonism in the regulation of 15-hydroxyprostaglandin dehydrogenase activity and messenger ribonucleic acid levels in human chorion and placental trophoblast cells at term. (PubMed id 12788907)^{1, 2, 9} Patel F.A.... Challis J.R.G. (2003)
Corticotropin-releasing hormone receptor type 1 and type 2 mediate differential effects on 15-hydroxy prostaglandin dehydrogenase expression in cultured human chorion trophoblasts. (PubMed id 17463062)^{1, 7, 9} Gao L....Ni X. (2007)
Role of glutamine 148 of human 15-hydroxyprostaglandin dehydrogenase in catalytic oxidation of prostaglandin E2. (PubMed id 16828555)^{1, 2, 9} Cho H.... Tai H.-H. (2006)
15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers. (PubMed id 15574495)^{1, 2, 9} Yan M.... Markowitz S.D. (2004)
Mutation in the HPGD gene encoding NAD+ dependent 15- hydroxyprostaglandin dehydrogenase underlies isolated congenital nail clubbing (ICNC). (PubMed id 18805827)^{1, 2, 9} Tariq M.... Ahmad W. (2009)
Site-directed mutagenesis of the conserved tyrosine 151 of human placental NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase yields a catalytically inactive enzyme. (PubMed id 2025296)^{1, 2, 9} Ensor C.M. and Tai H.-H. (1991)
Genetic variation in prostaglandin E2 synthesis and s ignaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma. (PubMed id 20086108)^{1, 4, 9} Poole E.M....Ulrich C.M. (2010)
Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy. (PubMed id 18500342)^{1, 2, 9} Uppal S.... Bonthron D.T. (2008)
Association of hydroxyprostaglandin dehydrogenase 15- (NAD) (HPGD) variants and colorectal cancer risk. (PubMed id 21047993)^{1, 4} Frank B....Nieters A. (2010)
High-affinity inhibitors of human NAD-dependent 15-hy droxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activi ty relationships. (PubMed id 21072165)^{1, 2} Niesen F.H....Simeonov A. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3248	HGNC: 5154	AceView: HPGD	Ensembl:ENSG00000164120	euGenes: HUgn3248
ECgene: HPGD	Kegg: 3248	H-InvDB: HPGD

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HPGD	Pharmacogenomics, SNPs, Pathways
SeattleSNPs	http://pga.gs.washington.edu/data/hpgd/

Intellectual Property for HPGD gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for HPGD gene:
Search GeneIP for patents involving HPGD

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for HPGD (15-PGDH/HPGD)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Recombinant/Natural Proteins for HPGD (15-PGDH/HPGD)
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	OriGene Antibodies for HPGD		OriGene RNAi products in human, mouse, rat for HPGD
	OriGene qPCR primer pairs and template standards for HPGD		OriGene Protein Over-expression Lysate for HPGD
	OriGene MassSpec something-or-other for HPGD		OriGene clones in human, mouse for HPGD
	OriGene qSTAR qPCR primer pairs in human, mouse for HPGD		OriGene Purified Protein for HPGD
	OriGene ORF clones in mouse, rat for HPGD		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for HPGD		OriGene Custom Protein Services for HPGD

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HPGD
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HPGD
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HPGD
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HPGD
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HPGD
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HPGD

	GenScript Custom Purified and Recombinant Proteins Services for HPGD		GenScript cDNA clones with any tag delivered in your preferred vector for HPGD
	GenScript Custom Assay Services for HPGD		GenScript Custom Superior Antibodies Services for HPGD
	GenScript Custom overexpressing Cell Line Services for HPGD		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in HPGD promoter
	Search Chromatin IP Primers for HPGD
	RT² qPCR Primer Assay in human, mouse, rat HPGD
	GNC Network for HPGD
	SABiosciences Custom PCR Arrays for HPGD

Search Tocris compounds for HPGD (PGDH)

	Proteins and Antibodies for HPGD
	Browse Sino Biological Cell Lysates
	cDNA Clones for HPGD
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	HPGD antibodies
	HPGD proteins
	HPGD lysates

	Antibodies for HPGD
	See all of Abcam's Antibodies, Kits and Proteins for HPGD
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for HPGD

	Proteins for HPGD
	Antibodies for HPGD
	ELISAs for HPGD
	CLIAs for HPGD

Search LifeMap BioReagents cell lines for HPGD

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HPGD

	SwitchGear 3'UTR luciferase reporter plasmids for HPGD
	SwitchGear Promoter luciferase reporter plasmids for HPGD

ThermoFisher Antibody for HPGD

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HPGD

	inGenious Targeting Laboratory - Custom generated mouse model solutions for HPGD
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HPGD

Customized:

	stable knockdown cell line services for HPGD
	inducible knockdown cell line services for HPGD
	design and validation of potent shRNA sequences against HPGD
	adenovirus for potent knockdown of HPGD
	stable overexpressing cell line services for HPGD
	inducible overexpressing cell line services for HPGD
	adenovirus for overexpression of HPGD

LSBio Antibodies in human, mouse, rat for HPGD

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes HPGD gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

HPGD Gene

Hydroxyprostaglandin Dehydrogenase 15-(NAD)

Aliases
for HPGD gene

Summaries
for HPGD gene

Genomic Views
for HPGD gene

Proteins
for HPGD gene

Protein Domains /
Families
for HPGD gene

Function
for HPGD gene

Pathways & Interactions
for HPGD gene

Drugs & Compounds
for HPGD gene

Transcripts
for HPGD gene

Expression
for HPGD gene

Orthologs
for HPGD gene

Paralogs
for HPGD gene

Genomic Variants
for HPGD gene

Disorders / Diseases
for HPGD gene

Publications
for HPGD gene

External Searches for HPGD gene

Genome Databases showing HPGD gene

Other Databases showing HPGD gene

Specialized Databases showing HPGD gene

Intellectual Property
for HPGD gene

Products
for HPGD gene

View Random Gene

preterm delivery
Colon Cancer
Prematurity
Colorectal Cancer
Adenoma
Bleeding
Inflammation
dysplasia
Carcinoma
Bladder Tumors
ADENOCARCINOMA LUNG
Chorioamnionitis
Breast Cancer
Pachydermoperiostosis
Tumors
NSCLC
Necrosis
Cancer
Cancer Lung
Labor Premature
COLON TUMOR

Advanced Search

Export list of displayed genes

HPGD Gene

Hydroxyprostaglandin Dehydrogenase 15-(NAD)

Aliasesfor HPGD gene

Summariesfor HPGD gene

Genomic Viewsfor HPGD gene

Proteinsfor HPGD gene

Protein Domains /Familiesfor HPGD gene

Functionfor HPGD gene

Pathways & Interactionsfor HPGD gene

Drugs & Compoundsfor HPGD gene

Transcriptsfor HPGD gene

Expression for HPGD gene

Orthologsfor HPGD gene

Paralogsfor HPGD gene

Genomic Variantsfor HPGD gene

Disorders / Diseasesfor HPGD gene

Publicationsfor HPGD gene

External Searches for HPGD gene

Genome Databases showing HPGD gene

Other Databases showing HPGD gene

Specialized Databases showing HPGD gene

Intellectual Propertyfor HPGD gene

Productsfor HPGD gene

View Random Gene

Aliases
for HPGD gene

Summaries
for HPGD gene

Genomic Views
for HPGD gene

Proteins
for HPGD gene

Protein Domains /
Families
for HPGD gene

Function
for HPGD gene

Pathways & Interactions
for HPGD gene

Drugs & Compounds
for HPGD gene

Transcripts
for HPGD gene

Expression
for HPGD gene

Orthologs
for HPGD gene

Paralogs
for HPGD gene

Genomic Variants
for HPGD gene

Disorders / Diseases
for HPGD gene

Publications
for HPGD gene

Intellectual Property
for HPGD gene

Products
for HPGD gene