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HPGD Gene(Protein Coding)

15-Hydroxyprostaglandin Dehydrogenase

GCID:
GC04M174490
GIFtS:
57
Genes Participants
UDN Logo

Aliases for HPGD Gene

Aliases for HPGD Gene

  • 15-Hydroxyprostaglandin Dehydrogenase 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 36C Member 1 3 4
  • 15-Hydroxyprostaglandin Dehydrogenase (NAD(+)) 2 3
  • Hydroxyprostaglandin Dehydrogenase 15-(NAD) 2 3
  • Prostaglandin Dehydrogenase 1 3 4
  • EC 1.1.1.141 4 56
  • 15-PGDH 3 4
  • SDR36C1 3 4
  • PGDH1 3 4
  • Short Chain Dehydrogenase/Reductase Family 36C, Member 1 2
  • NAD+-Dependent 15-Hydroxyprostaglandin Dehydrogenase 3
  • 15-Hydroxyprostaglandin Dehydrogenase [NAD(+)] 3
  • EC 1.1.1 56
  • PHOAR1 3
  • PGDH 3

External Ids for HPGD Gene

Previous GeneCards Identifiers for HPGD Gene

  • GC04M176331
  • GC04M175949
  • GC04M176107
  • GC04M175786
  • GC04M175647
  • GC04M175411
  • GC04M171160

Summaries for HPGD Gene

Entrez Gene Summary for HPGD Gene

  • This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

GeneCards Summary for HPGD Gene

HPGD (15-Hydroxyprostaglandin Dehydrogenase) is a Protein Coding gene. Diseases associated with HPGD include Digital Clubbing, Isolated Congenital and Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 1. Among its related pathways are Metabolism and Arachidonic acid metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and NAD binding. An important paralog of this gene is HSD17B8.

UniProtKB/Swiss-Prot for HPGD Gene

  • Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells.

Gene Wiki entry for HPGD Gene

Additional gene information for HPGD Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HPGD Gene

Genomics for HPGD Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for HPGD Gene

Promoters and enhancers for HPGD Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH04I174521 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 559 +0.1 55 3.9 PKNOX1 ATF1 ZNF133 SIN3A FEZF1 TCF12 GLIS2 REST ZNF592 MYNN HPGD LOC100419741 MIR4276
GH04I174580 Enhancer 0.6 FANTOM5 48 -57.6 -57642 0.3 FOSL1 ATF4 VEZF1 EP300 HPGD LOC105377549 LOC100419741
GH04I174591 Enhancer 0.8 FANTOM5 Ensembl 24.2 -68.5 -68546 1 SMARCE1 TEAD4 VEZF1 JUNB ZMYM3 RUNX3 SPI1 HPGD LOC105377549 LOC100419741
GH04I174582 Enhancer 0.2 FANTOM5 52 -59.8 -59846 0.2 HPGD LOC105377549 LOC100419741
GH04I174382 Enhancer 0.9 Ensembl ENCODE 10.4 +139.6 139568 1.6 ZNF740 L3MBTL2 USF2 CBFA2T3 MNT DPF2 RELA ZNF592 CHAMP1 IRF9 HPGD CEP44 ENSG00000249875 LOC105377547 MIR4276
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HPGD on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HPGD gene promoter:

Genomic Locations for HPGD Gene

Genomic Locations for HPGD Gene
chr4:174,490,177-174,523,154
(GRCh38/hg38)
Size:
32,978 bases
Orientation:
Minus strand
chr4:175,411,328-175,444,305
(GRCh37/hg19)

Genomic View for HPGD Gene

Genes around HPGD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HPGD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HPGD Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for HPGD Gene

Proteins for HPGD Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for HPGD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15428-PGDH_HUMAN
    Recommended name:
    15-hydroxyprostaglandin dehydrogenase [NAD(+)]
    Protein Accession:
    P15428
    Secondary Accessions:
    • B4DTA4
    • B4DU74
    • B4DV57
    • D3DP43
    • E7EV11
    • O00749
    • Q06F08
    • Q12998

    Protein attributes for HPGD Gene

    Size:
    266 amino acids
    Molecular mass:
    28977 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for HPGD Gene

    Alternative splice isoforms for HPGD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HPGD Gene

Protein Expression for HPGD Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for HPGD Gene

P15428:
  • SIEKEENMG
  • GAKVALVDWNLE
  • QLRDTFRKVVDHFG
  • LMNSGVR
  • QCDVADQ
  • KVALVTG
  • LIEDDALNGAIMKIT

Post-translational modifications for HPGD Gene

No Post-translational modifications

Other Protein References for HPGD Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for HPGD Gene

Gene Families for HPGD Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for HPGD Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for HPGD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P15428

UniProtKB/Swiss-Prot:

PGDH_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with HPGD: view

Function for HPGD Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for HPGD Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=3.4 uM for prostaglandin E2 {ECO:0000269 PubMed:16828555}; KM=38 uM for NAD {ECO:0000269 PubMed:16828555};
UniProtKB/Swiss-Prot CatalyticActivity:
(5Z,13E,15S)-11-alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD(+) = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH.
UniProtKB/Swiss-Prot Function:
Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells.
UniProtKB/Swiss-Prot Induction:
Down-regulated by cortisol, dexamethasone and betamethasone. Down-regulated in colon cancer. Up-regulated by TGFB1.

Enzyme Numbers (IUBMB) for HPGD Gene

Phenotypes From GWAS Catalog for HPGD Gene

Gene Ontology (GO) - Molecular Function for HPGD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IDA 2025296
GO:0004957 prostaglandin E receptor activity IDA 10198228
GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity TAS --
GO:0016491 oxidoreductase activity IEA --
GO:0042803 protein homodimerization activity TAS 2025296
genes like me logo Genes that share ontologies with HPGD: view
genes like me logo Genes that share phenotypes with HPGD: view

Human Phenotype Ontology for HPGD Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for HPGD Gene

MGI Knock Outs for HPGD:

Animal Model Products

Clone Products

  • Addgene plasmids for HPGD

No data available for Transcription Factor Targets and HOMER Transcription for HPGD Gene

Localization for HPGD Gene

Subcellular locations from UniProtKB/Swiss-Prot for HPGD Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HPGD gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 2
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HPGD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0016323 basolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with HPGD: view

Pathways & Interactions for HPGD Gene

genes like me logo Genes that share pathways with HPGD: view

Pathways by source for HPGD Gene

1 BioSystems pathway for HPGD Gene
1 KEGG pathway for HPGD Gene
1 GeneGo (Thomson Reuters) pathway for HPGD Gene

Gene Ontology (GO) - Biological Process for HPGD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development IEA --
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006693 prostaglandin metabolic process IDA,IEA 16828555
GO:0007179 transforming growth factor beta receptor signaling pathway IDA 15574495
genes like me logo Genes that share ontologies with HPGD: view

No data available for SIGNOR curated interactions for HPGD Gene

Drugs & Compounds for HPGD Gene

Products:

  1. Drug

(27) Drugs for HPGD Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NADH Approved Nutra Target 0
Dinoprost Investigational Pharma 12
NAD Pharma Full agonist, Agonist 0
Prostaglandin E2 Pharma activates the PGE2 receptor, Major endogenous prostanoid 0

(16) Additional Compounds for HPGD Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
15-Keto-prostaglandin F2a
  • 15-Keto-PGF2a
  • 15-Keto-PGF2alpha
  • 15-Keto-prostaglandin F2a
  • 15-Keto-prostaglandin F2alpha
  • 15-Ketoprostaglandin F2alpha
 35850-13-6
genes like me logo Genes that share compounds with HPGD: view

Transcripts for HPGD Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for HPGD Gene

(7) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(321) Selected AceView cDNA sequences:
(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HPGD Gene

Hydroxyprostaglandin dehydrogenase 15-(NAD):
Representative Sequences:

Clone Products

  • Addgene plasmids for HPGD

Alternative Splicing Database (ASD) splice patterns (SP) for HPGD Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - -
SP2: -
SP3: - - - - - -
SP4: - - -
SP5: - - -
SP6: -

Relevant External Links for HPGD Gene

GeneLoc Exon Structure for
HPGD
ECgene alternative splicing isoforms for
HPGD

Expression for HPGD Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HPGD Gene

mRNA expression in normal human tissues for HPGD Gene
mRNA expression by BioGPS for HPGD GenemRNA expression by GTEx for HPGD Gene

mRNA differential expression in normal tissues according to GTEx for HPGD Gene

This gene is overexpressed in Bladder (x5.1), Vagina (x4.9), Whole Blood (x4.8), Liver (x4.5), and Esophagus - Mucosa (x4.3).

Protein differential expression in normal tissues from HIPED for HPGD Gene

This gene is overexpressed in Lung (14.4), Placenta (8.9), Cardia (8.3), and Stomach (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HPGD Gene



NURSA nuclear receptor signaling pathways regulating expression of HPGD Gene:

HPGD

SOURCE GeneReport for Unigene cluster for HPGD Gene:

Hs.596913

mRNA Expression by UniProt/SwissProt for HPGD Gene:

P15428-PGDH_HUMAN
Tissue specificity: Detected in colon epithelium (at protein level).

Evidence on tissue expression from TISSUES for HPGD Gene

  • Intestine(4.8)
  • Pancreas(4.3)
  • Lung(3.8)
  • Nervous system(3.5)
  • Skin(3.1)
  • Stomach(2.7)
  • Kidney(2.6)
  • Liver(2.5)

Phenotype-based relationships between genes and organs from Gene ORGANizer for HPGD Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • skeletal muscle
  • skeleton
Organs:
Head and neck:
  • ear
  • eye
  • eyelid
  • face
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • scalp
  • skull
Thorax:
  • chest wall
  • clavicle
  • heart
  • rib
  • rib cage
  • scapula
  • sternum
Pelvis:
  • pelvis
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • nail
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • bone marrow
  • hair
  • skin
  • spinal column
  • sweat gland
  • vertebrae
genes like me logo Genes that share expression patterns with HPGD: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for HPGD Gene

Orthologs for HPGD Gene

This gene was present in the common ancestor of animals.

Orthologs for HPGD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia HPGD 33 34
  • 99.87 (n)
dog
(Canis familiaris)
 Mammalia HPGD 33 34
  • 92.36 (n)
cow
(Bos Taurus)
 Mammalia HPGD 33 34
  • 90.23 (n)
mouse
(Mus musculus)
 Mammalia Hpgd 33 16 34
  • 88.13 (n)
rat
(Rattus norvegicus)
 Mammalia Hpgd 33
  • 87.88 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 34
  • 84 (a)
 OneToMany
-- 34
  • 82 (a)
 OneToMany
oppossum
(Monodelphis domestica)
 Mammalia HPGD 34
  • 83 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves HPGD 33 34
  • 75.13 (n)
lizard
(Anolis carolinensis)
 Reptilia HPGD 34
  • 61 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia hpgd 33
  • 69.79 (n)
Str.8168 33
zebrafish
(Danio rerio)
 Actinopterygii LOC565975 33
  • 62.84 (n)
CU928070.1 34
  • 57 (a)
 OneToOne
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.6946 33
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP001753 33
  • 49.18 (n)
fruit fly
(Drosophila melanogaster)
 Insecta CG4842 35 34
  • 36 (a)
Pdh 35 34
  • 36 (a)
CG18814 34
  • 27 (a)
 OneToMany
Fbp2 34
  • 25 (a)
 OneToMany
Adhr 34
  • 24 (a)
 OneToMany
Adh 34
  • 23 (a)
 OneToMany
Species where no ortholog for HPGD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HPGD Gene

ENSEMBL:
Gene Tree for HPGD (if available)
TreeFam:
Gene Tree for HPGD (if available)

Paralogs for HPGD Gene

Paralogs for HPGD Gene

(6) SIMAP similar genes for HPGD Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with HPGD: view

Variants for HPGD Gene

Sequence variations from dbSNP and Humsavar for HPGD Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1050145 benign, Pachydermoperiostosis syndrome, Digital clubbing, isolated congenital 174,522,005(-) C/T 5_prime_UTR_variant, coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs1056279271 uncertain-significance, Pachydermoperiostosis syndrome, Digital clubbing, isolated congenital 174,490,478(-) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs116796476 uncertain-significance, Pachydermoperiostosis syndrome, Digital clubbing, isolated congenital 174,522,672(-) C/G/T 5_prime_UTR_variant, non_coding_transcript_variant
rs117270501 uncertain-significance, Pachydermoperiostosis syndrome, Digital clubbing, isolated congenital 174,492,077(-) T/C 3_prime_UTR_variant, coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, synonymous_variant
rs121434480 pathogenic, Cranioosteoarthropathy, Pachydermoperiostosis syndrome, Cranioosteoarthropathy (COA) [MIM:259100] 174,508,699(-) C/G coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HPGD Gene

Variant ID Type Subtype PubMed ID
dgv1043e214 CNV loss 21293372
nsv509946 OTHER sequence alteration 20534489
nsv525487 CNV gain 19592680

Variation tolerance for HPGD Gene

Residual Variation Intolerance Score: 58.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HPGD Gene

Human Gene Mutation Database (HGMD)
HPGD
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HPGD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HPGD Gene

Disorders for HPGD Gene

MalaCards: The human disease database

(8) MalaCards diseases for HPGD Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search HPGD in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PGDH_HUMAN
  • Cranioosteoarthropathy (COA) [MIM:259100]: A form of osteoarthropathy characterized by swelling of the joints, digital clubbing, hyperhidrosis, delayed closure of the fontanels, periostosis, and variable patent ductus arteriosus. Pachydermia is not a prominent feature. {ECO:0000269 PubMed:18500342}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Hypertrophic osteoarthropathy, primary, autosomal recessive, 1 (PHOAR1) [MIM:259100]: A disease characterized by digital clubbing, periostosis, acroosteolysis, painful joint enlargement, and variable features of pachydermia that include thickened facial skin and a thickened scalp. Other developmental anomalies include delayed closure of the cranial sutures and congenital heart disease. {ECO:0000269 PubMed:18500342}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Isolated congenital nail clubbing (ICNC) [MIM:119900]: A rare genodermatosis characterized by enlargement of the nail plate and terminal segments of the fingers and toes, resulting from proliferation of the connective tissues between the nail matrix and the distal phalanx. It is usually symmetrical and bilateral (in some cases unilateral). In nail clubbing usually the distal end of the nail matrix is relatively high compared to the proximal end, while the nail plate is complete but its dimensions and diameter more or less vary in comparison to normal. There may be different fingers and toes involved to varying degrees. Some fingers or toes are spared, but the thumbs are almost always involved. {ECO:0000269 PubMed:18805827}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for HPGD

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HPGD: view

No data available for Genatlas for HPGD Gene

Publications for HPGD Gene

  1. Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma. (PMID: 20086108) Poole EM … Ulrich CM (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 22 44 58
  2. Mutation in the HPGD gene encoding NAD+ dependent 15-hydroxyprostaglandin dehydrogenase underlies isolated congenital nail clubbing (ICNC). (PMID: 18805827) Tariq M … Ahmad W (Journal of medical genetics 2009) 3 4 22 58
  3. Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy. (PMID: 18500342) Uppal S … Bonthron DT (Nature genetics 2008) 3 4 22 58
  4. Role of glutamine 148 of human 15-hydroxyprostaglandin dehydrogenase in catalytic oxidation of prostaglandin E2. (PMID: 16828555) Cho H … Tai HH (Bioorganic & medicinal chemistry 2006) 3 4 22 58
  5. 15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers. (PMID: 15574495) Yan M … Markowitz SD (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 22 58

Products for HPGD Gene

  • Addgene plasmids for HPGD

Sources for HPGD Gene

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