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Aliases for HPGD Gene

Aliases for HPGD Gene

  • Hydroxyprostaglandin Dehydrogenase 15-(NAD) 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 36C Member 1 3 4
  • Prostaglandin Dehydrogenase 1 3 4
  • EC 1.1.1.141 4 63
  • 15-PGDH 3 4
  • SDR36C1 3 4
  • PGDH1 3 4
  • Short Chain Dehydrogenase/Reductase Family 36C, Member 1 3
  • NAD+-Dependent 15-Hydroxyprostaglandin Dehydrogenase 3
  • Short Chain Dehydrogenase/Reductase Family 36C 2
  • Member 1 2
  • EC 1.1.1 63
  • PHOAR1 3
  • PGDH 3

External Ids for HPGD Gene

Previous GeneCards Identifiers for HPGD Gene

  • GC04M176331
  • GC04M175949
  • GC04M176107
  • GC04M175786
  • GC04M175647
  • GC04M175411
  • GC04M171160

Summaries for HPGD Gene

Entrez Gene Summary for HPGD Gene

  • This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

GeneCards Summary for HPGD Gene

HPGD (Hydroxyprostaglandin Dehydrogenase 15-(NAD)) is a Protein Coding gene. Diseases associated with HPGD include cranioosteoarthropathy and digital clubbing, isolated congenital. Among its related pathways are Metabolism and Arachidonic acid metabolism. GO annotations related to this gene include protein homodimerization activity and NAD binding. An important paralog of this gene is DECR2.

UniProtKB/Swiss-Prot for HPGD Gene

  • Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells.

Gene Wiki entry for HPGD Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HPGD Gene

Genomics for HPGD Gene

Regulatory Elements for HPGD Gene

Promoters for HPGD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HPGD on UCSC Golden Path with GeneCards custom track

Genomic Location for HPGD Gene

Chromosome:
4
Start:
174,490,177 bp from pter
End:
174,523,154 bp from pter
Size:
32,978 bases
Orientation:
Minus strand

Genomic View for HPGD Gene

Genes around HPGD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HPGD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HPGD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HPGD Gene

Proteins for HPGD Gene

  • Protein details for HPGD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15428-PGDH_HUMAN
    Recommended name:
    15-hydroxyprostaglandin dehydrogenase [NAD(+)]
    Protein Accession:
    P15428
    Secondary Accessions:
    • B4DTA4
    • B4DU74
    • B4DV57
    • D3DP43
    • E7EV11
    • O00749
    • Q06F08
    • Q12998

    Protein attributes for HPGD Gene

    Size:
    266 amino acids
    Molecular mass:
    28977 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for HPGD Gene

    Alternative splice isoforms for HPGD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HPGD Gene

Proteomics data for HPGD Gene at MOPED

Selected DME Specific Peptides for HPGD Gene

Post-translational modifications for HPGD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains & Families for HPGD Gene

Gene Families for HPGD Gene

Graphical View of Domain Structure for InterPro Entry

P15428

UniProtKB/Swiss-Prot:

PGDH_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with HPGD: view

Function for HPGD Gene

Molecular function for HPGD Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=3.4 uM for prostaglandin E2 {ECO:0000269 PubMed:16828555}; KM=38 uM for NAD {ECO:0000269 PubMed:16828555};
UniProtKB/Swiss-Prot CatalyticActivity:
(5Z,13E,15S)-11-alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD(+) = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH.
UniProtKB/Swiss-Prot Function:
Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells.
UniProtKB/Swiss-Prot Induction:
Down-regulated by cortisol, dexamethasone and betamethasone. Down-regulated in colon cancer. Up-regulated by TGFB1.

Enzyme Numbers (IUBMB) for HPGD Gene

Gene Ontology (GO) - Molecular Function for HPGD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with HPGD: view
genes like me logo Genes that share phenotypes with HPGD: view

Human Phenotype Ontology for HPGD Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for HPGD Gene

MGI Knock Outs for HPGD:

Animal Model Products

No data available for Transcription Factor Targets and HOMER Transcription for HPGD Gene

Localization for HPGD Gene

Subcellular locations from UniProtKB/Swiss-Prot for HPGD Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HPGD Gene COMPARTMENTS Subcellular localization image for HPGD gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
plasma membrane 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HPGD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with HPGD: view

Pathways & Interactions for HPGD Gene

genes like me logo Genes that share pathways with HPGD: view

Pathways by source for HPGD Gene

Interacting Proteins for HPGD Gene

Gene Ontology (GO) - Biological Process for HPGD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006693 prostaglandin metabolic process IDA 16828555
GO:0007565 female pregnancy IDA 15531523
GO:0007567 parturition IDA 15531523
GO:0019369 arachidonic acid metabolic process TAS --
GO:0019372 lipoxygenase pathway TAS 15581601
genes like me logo Genes that share ontologies with HPGD: view

No data available for SIGNOR curated interactions for HPGD Gene

Drugs & Compounds for HPGD Gene

(25) Drugs for HPGD Gene - From: Novoseek, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dinoprostone Approved Pharma Major endogenous prostanoid 74
NADH Nutra Target 0
NAD Pharma Full agonist, Agonist 0

(18) Additional Compounds for HPGD Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
15-Keto-prostaglandin F2a
  • 15-Keto-PGF2a
  • 15-Keto-PGF2alpha
  • 15-Keto-prostaglandin F2a
  • 15-Keto-prostaglandin F2alpha
  • 15-Ketoprostaglandin F2alpha
35850-13-6
Prostaglandin F2a
  • (+)-Prostaglandin F2a
  • (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate
  • (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoic acid
  • (5Z,13E,15S)-9a,11a,15-trihydroxyprosta-5,13-dien-1-oate
  • (5Z,13E,15S)-9a,11a,15-trihydroxyprosta-5,13-dien-1-oic acid
551-11-1
genes like me logo Genes that share compounds with HPGD: view

Transcripts for HPGD Gene

Unigene Clusters for HPGD Gene

Hydroxyprostaglandin dehydrogenase 15-(NAD):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HPGD Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - -
SP2: -
SP3: - - - - - -
SP4: - - -
SP5: - - -
SP6: -

Relevant External Links for HPGD Gene

GeneLoc Exon Structure for
HPGD
ECgene alternative splicing isoforms for
HPGD

Expression for HPGD Gene

mRNA expression in normal human tissues for HPGD Gene

mRNA differential expression in normal tissues according to GTEx for HPGD Gene

This gene is overexpressed in Bladder (x5.1), Vagina (x4.9), Whole Blood (x4.8), Liver (x4.5), and Esophagus - Mucosa (x4.3).

Protein differential expression in normal tissues from HIPED for HPGD Gene

This gene is overexpressed in Lung (14.4), Placenta (8.9), Cardia (8.3), and Stomach (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HPGD Gene



SOURCE GeneReport for Unigene cluster for HPGD Gene Hs.596913

mRNA Expression by UniProt/SwissProt for HPGD Gene

P15428-PGDH_HUMAN
Tissue specificity: Detected in colon epithelium (at protein level).
genes like me logo Genes that share expression patterns with HPGD: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for HPGD Gene

Orthologs for HPGD Gene

This gene was present in the common ancestor of animals.

Orthologs for HPGD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HPGD 36
  • 100 (a)
OneToOne
HPGD 35
  • 99.87 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia HPGD 35
  • 90.23 (n)
  • 93.23 (a)
HPGD 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HPGD 36
  • 94 (a)
OneToOne
HPGD 35
  • 92.36 (n)
  • 94.36 (a)
mouse
(Mus musculus)
Mammalia Hpgd 16
Hpgd 36
  • 88 (a)
OneToOne
Hpgd 35
  • 88.13 (n)
  • 89.77 (a)
oppossum
(Monodelphis domestica)
Mammalia HPGD 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 82 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Hpgd 35
  • 87.88 (n)
  • 89.02 (a)
chicken
(Gallus gallus)
Aves HPGD 35
  • 75.13 (n)
  • 73.48 (a)
HPGD 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HPGD 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hpgd 35
  • 69.79 (n)
  • 71.09 (a)
Str.8168 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6946 35
zebrafish
(Danio rerio)
Actinopterygii LOC565975 35
  • 62.84 (n)
  • 57.09 (a)
CU928070.1 36
  • 57 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001753 35
  • 49.18 (n)
  • 39.89 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4842 37
  • 36 (a)
Pdh 37
  • 36 (a)
Adh 36
  • 23 (a)
OneToMany
Adhr 36
  • 24 (a)
OneToMany
CG18814 36
  • 27 (a)
OneToMany
CG4842 36
  • 28 (a)
OneToMany
Fbp2 36
  • 25 (a)
OneToMany
Pdh 36
  • 29 (a)
OneToMany
Species with no ortholog for HPGD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HPGD Gene

ENSEMBL:
Gene Tree for HPGD (if available)
TreeFam:
Gene Tree for HPGD (if available)

Paralogs for HPGD Gene

(6) SIMAP similar genes for HPGD Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with HPGD: view

Variants for HPGD Gene

Sequence variations from dbSNP and Humsavar for HPGD Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_006972 -
VAR_046209 Cranioosteoarthropathy (COA)
VAR_060792 Isolated congenital nail clubbing (ICNC)
rs1816204 -- 174,492,493(+) CTAGC(A/G)TTTAC intron-variant
rs1863642 -- 174,512,762(+) GATGT(G/T)AAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HPGD Gene

Variant ID Type Subtype PubMed ID
nsv525487 CNV Gain 19592680
nsv881299 CNV Loss 21882294
nsv509946 CNV Loss 20534489
nsv880289 CNV Gain 21882294
nsv881270 CNV Loss 21882294
nsv880970 CNV Loss 21882294
nsv880884 CNV Loss 21882294

Variation tolerance for HPGD Gene

Residual Variation Intolerance Score: 58.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HPGD Gene

HapMap Linkage Disequilibrium report
HPGD
Human Gene Mutation Database (HGMD)
HPGD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HPGD Gene

Disorders for HPGD Gene

MalaCards: The human disease database

(11) MalaCards diseases for HPGD Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cranioosteoarthropathy
  • hypertrophic osteoarthropathy, primary, autosomal recessive 1
digital clubbing, isolated congenital
  • isolated congenital digital clubbing
primary hypertrophic osteoarthropathy
  • pachydermoperiostosis of nail
patent ductus arteriosus
  • ductus arteriosus, patent
apocrine adenocarcinoma
  • apocrine carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search HPGD in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PGDH_HUMAN
  • Hypertrophic osteoarthropathy, primary, autosomal recessive, 1 (PHOAR1) [MIM:259100]: A disease characterized by digital clubbing, periostosis, acroosteolysis, painful joint enlargement, and variable features of pachydermia that include thickened facial skin and a thickened scalp. Other developmental anomalies include delayed closure of the cranial sutures and congenital heart disease. {ECO:0000269 PubMed:18500342}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Cranioosteoarthropathy (COA) [MIM:259100]: A form of osteoarthropathy characterized by swelling of the joints, digital clubbing, hyperhidrosis, delayed closure of the fontanels, periostosis, and variable patent ductus arteriosus. Pachydermia is not a prominent feature. {ECO:0000269 PubMed:18500342}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Isolated congenital nail clubbing (ICNC) [MIM:119900]: A rare genodermatosis characterized by enlargement of the nail plate and terminal segments of the fingers and toes, resulting from proliferation of the connective tissues between the nail matrix and the distal phalanx. It is usually symmetrical and bilateral (in some cases unilateral). In nail clubbing usually the distal end of the nail matrix is relatively high compared to the proximal end, while the nail plate is complete but its dimensions and diameter more or less vary in comparison to normal. There may be different fingers and toes involved to varying degrees. Some fingers or toes are spared, but the thumbs are almost always involved. {ECO:0000269 PubMed:18805827}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for HPGD

Genetic Association Database (GAD)
HPGD
Human Genome Epidemiology (HuGE) Navigator
HPGD
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HPGD
genes like me logo Genes that share disorders with HPGD: view

No data available for Genatlas for HPGD Gene

Publications for HPGD Gene

  1. Mechanism of cortisol/progesterone antagonism in the regulation of 15-hydroxyprostaglandin dehydrogenase activity and messenger ribonucleic acid levels in human chorion and placental trophoblast cells at term. (PMID: 12788907) Patel F.A. … Challis J.R.G. (J. Clin. Endocrinol. Metab. 2003) 3 4 23 67
  2. Corticotropin-releasing hormone receptor type 1 and type 2 mediate differential effects on 15-hydroxy prostaglandin dehydrogenase expression in cultured human chorion trophoblasts. (PMID: 17463062) Gao L. … Ni X. (Endocrinology 2007) 3 23 25
  3. Loss of 15-hydroxyprostaglandin dehydrogenase increases prostaglandin E2 in pancreatic tumors. (PMID: 19820419) Pham H. … Eibl G. (Pancreas 2010) 3 23
  4. Reduction of 15-hydroxyprostaglandin dehydrogenase expression is an independent predictor of poor survival associated with enhanced cell proliferation in gastric adenocarcinoma. (PMID: 19917058) Tatsuwaki H. … Arakawa T. (Cancer Sci. 2010) 3 23
  5. Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma. (PMID: 20086108) Poole E.M. … Ulrich C.M. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 23

Products for HPGD Gene

Sources for HPGD Gene

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