Aliases for HPGD Gene
Aliases for HPGD Gene
External Ids for HPGD Gene
- HGNC: 5154
- Entrez Gene: 3248
- Ensembl: ENSG00000164120
- OMIM: 601688
- UniProtKB: P15428
Previous GeneCards Identifiers for HPGD Gene
- GC04M176331
- GC04M175949
- GC04M176107
- GC04M175786
- GC04M175647
- GC04M175411
- GC04M171160
Summaries for HPGD Gene
-
This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
GeneCards Summary for HPGD Gene
HPGD (15-Hydroxyprostaglandin Dehydrogenase) is a Protein Coding gene. Diseases associated with HPGD include Digital Clubbing, Isolated Congenital and Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 1. Among its related pathways are Metabolism and Arachidonic acid metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and NAD binding. An important paralog of this gene is HSD17B8.
UniProtKB/Swiss-Prot for HPGD Gene
-
Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells.
Additional gene information for HPGD Gene
- Monarch Initiative
- Search for HPGD at DataMed
- Search for HPGD at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HPGD Gene
Genomics for HPGD Gene
GeneHancer (GH) Regulatory Elements for HPGD Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH04I174521 | Promoter/Enhancer | 1.9 | EPDnew Ensembl ENCODE | 559 | +0.1 | 55 | 3.9 | PKNOX1 ATF1 ZNF133 SIN3A FEZF1 TCF12 GLIS2 REST ZNF592 MYNN | HPGD LOC100419741 MIR4276 | |
GH04I174580 | Enhancer | 0.6 | FANTOM5 | 48 | -57.6 | -57642 | 0.3 | FOSL1 ATF4 VEZF1 EP300 | HPGD LOC105377549 LOC100419741 | |
GH04I174591 | Enhancer | 0.8 | FANTOM5 Ensembl | 24.2 | -68.5 | -68546 | 1 | SMARCE1 TEAD4 VEZF1 JUNB ZMYM3 RUNX3 SPI1 | HPGD LOC105377549 LOC100419741 | |
GH04I174582 | Enhancer | 0.2 | FANTOM5 | 52 | -59.8 | -59846 | 0.2 | HPGD LOC105377549 LOC100419741 | ||
GH04I174382 | Enhancer | 0.9 | Ensembl ENCODE | 10.4 | +139.6 | 139568 | 1.6 | ZNF740 L3MBTL2 USF2 CBFA2T3 MNT DPF2 RELA ZNF592 CHAMP1 IRF9 | HPGD CEP44 ENSG00000249875 LOC105377547 MIR4276 |
- Top Transcription factor binding sites by QIAGEN in the HPGD gene promoter:
Regulatory Element Products
Genomic Locations for HPGD Gene
- chr4:174,490,177-174,523,154
- (GRCh38/hg38)
- Size:
- 32,978 bases
- Orientation:
- Minus strand
- chr4:175,411,328-175,444,305
- (GRCh37/hg19)
Genomic View for HPGD Gene
- Cytogenetic band:
-
- 4q34.1 by Ensembl
- 4q34.1 by Entrez Gene
- 4q34.1 by HGNC


RefSeq DNA sequence for HPGD Gene
Proteins for HPGD Gene
-
Protein details for HPGD Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P15428-PGDH_HUMAN
- Recommended name:
- 15-hydroxyprostaglandin dehydrogenase [NAD(+)]
- Protein Accession:
- P15428
- B4DTA4
- B4DU74
- B4DV57
- D3DP43
- E7EV11
- O00749
- Q06F08
- Q12998
Protein attributes for HPGD Gene
- Size:
- 266 amino acids
- Molecular mass:
- 28977 Da
- Quaternary structure:
-
- Homodimer.
Protein Expression for HPGD Gene
Selected DME Specific Peptides for HPGD Gene
- P15428:
-
- SIEKEENMG
- GAKVALVDWNLE
- QLRDTFRKVVDHFG
- LMNSGVR
- QCDVADQ
- KVALVTG
- LIEDDALNGAIMKIT
Post-translational modifications for HPGD Gene
Other Protein References for HPGD Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for HPGD (15-PGDH/HPGD)
- Novus Biologicals Antibodies for HPGD
-
Abcam antibodies for HPGD
- Invitrogen Antibodies for HPGD
- GeneTex HPGD antibody for HPGD
-
Santa Cruz Biotechnology (SCBT) Antibodies for HPGD
- Sino Biological Antibodies for HPGD
Protein Products
- R&D Systems Proteins and Enzymes for HPGD (15-PGDH/HPGD)
-
OriGene Purified Proteins for HPGD
- Search Origene for MassSpec and Protein Over-expression Lysates for HPGD
- Origene Custom Protein Services for HPGD
- Sino Biological Recombinant Proteins for HPGD
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for HPGD
- Search GeneTex for Proteins for HPGD
-
ProSci Proteins for HPGD
-
Abcam proteins for HPGD
Domains & Families for HPGD Gene
Gene Families for HPGD Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Enzymes
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for HPGD Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HPGD Gene
Graphical View of Domain Structure for InterPro Entry
P15428UniProtKB/Swiss-Prot:
PGDH_HUMAN :- Belongs to the short-chain dehydrogenases/reductases (SDR) family.
- Family:
-
- Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Function for HPGD Gene
Molecular function for HPGD Gene
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=3.4 uM for prostaglandin E2 {ECO:0000269 PubMed:16828555}; KM=38 uM for NAD {ECO:0000269 PubMed:16828555};
- UniProtKB/Swiss-Prot CatalyticActivity:
- (5Z,13E,15S)-11-alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD(+) = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH.
- UniProtKB/Swiss-Prot Function:
- Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells.
- UniProtKB/Swiss-Prot Induction:
- Down-regulated by cortisol, dexamethasone and betamethasone. Down-regulated in colon cancer. Up-regulated by TGFB1.
Enzyme Numbers (IUBMB) for HPGD Gene
Phenotypes From GWAS Catalog for HPGD Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003824 | catalytic activity | IDA | 2025296 |
GO:0004957 | prostaglandin E receptor activity | IDA | 10198228 |
GO:0016404 | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity | TAS | -- |
GO:0016491 | oxidoreductase activity | IEA | -- |
GO:0042803 | protein homodimerization activity | TAS | 2025296 |
Phenotypes for HPGD Gene
- MGI mutant phenotypes for HPGD:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for HPGD:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability ratio
- Decreased NF-kappaB reporter expression
- Decreased viability after Maraba virus infection
- Decreased influenza A/WSN/33 replication
- Increased mitotic index
- Decreased influenza A H1N1 (A/Hamburg/04/2009) virus numbers
Animal Models for HPGD Gene
- MGI Knock Outs for HPGD:
-
- Hpgd tm1Bhk
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for HPGD
-
-
ViGene Biosciences lentiviral particle packaged cDNA for HPGD gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HPGD gene
- Search ViGene Biosciences for HPGD
CRISPR Products
-
OriGene CRISPR knockouts for HPGD
- genomics-online: gRNA clones - Search results for 137 available HPGD gene related products
- Overview of 137 available HPGD gene related products
-
Recommended
- Applied Biological Materials CRISPR for HPGD
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HPGD
- GenScript: Design CRISPR guide RNA sequences for HPGD
miRNA for HPGD Gene
- miRTarBase miRNAs that target HPGD
miRNA Products
- Search ViGene Biosciences for HPGD
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for HPGD
- Browse OriGene Inhibitory RNA Products For HPGD
- genomics-online: shRNA clones - Search results for 137 available HPGD gene related products
- Overview of 137 available HPGD gene related products
-
Recommended
-
ViGene Biosciences ready-to-package AAV shRNAs for HPGD gene
Clone Products
-
OriGene ORF clones in human for HPGD
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HPGD
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for HPGD
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HPGD
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for HPGD
- genomics-online: cdna clones - Search results for 137 available HPGD gene related products
- Overview of 137 available HPGD gene related products
-
Recommended
- orf clones - Search results for 137 available HPGD gene related products
- Overview of 137 available HPGD gene related products
-
Recommended
- Applied Biological Materials Clones for HPGD
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for HPGD
-
ViGene Biosciences adenoviral particle packaged cDNA for HPGD gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HPGD gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HPGD gene
No data available for Transcription Factor Targets and HOMER Transcription for HPGD Gene
Localization for HPGD Gene
Subcellular locations from UniProtKB/Swiss-Prot for HPGD Gene
- Cytoplasm.
- Cytosol (3)
- Nucleoplasm (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | IEA | -- |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0016323 | basolateral plasma membrane | IEA | -- |
Pathways & Interactions for HPGD Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Arachidonic acid metabolism | ||
2 | Metabolism |
.37
|
|
3 | Transcriptional misregulation in cancer | ||
4 | Prostaglandin 2 biosynthesis and metabolism FM | ||
5 | Prostaglandin Synthesis and Regulation |
Pathways by source for HPGD Gene
1 BioSystems pathway for HPGD Gene
1 KEGG pathway for HPGD Gene
1 GeneGo (Thomson Reuters) pathway for HPGD Gene
Interacting Proteins for HPGD Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001822 | kidney development | IEA | -- |
GO:0006629 | lipid metabolic process | IEA | -- |
GO:0006631 | fatty acid metabolic process | IEA | -- |
GO:0006693 | prostaglandin metabolic process | IDA,IEA | 16828555 |
GO:0007179 | transforming growth factor beta receptor signaling pathway | IDA | 15574495 |
No data available for SIGNOR curated interactions for HPGD Gene
Drugs & Compounds for HPGD Gene
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
15-Keto-prostaglandin F2a |
|
35850-13-6 |
|
Transcripts for HPGD Gene
mRNA/cDNA for HPGD Gene
- (7) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (321) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HPGD Gene
CRISPR Products
-
OriGene CRISPR knockouts for HPGD
- genomics-online: gRNA clones - Search results for 137 available HPGD gene related products
- Overview of 137 available HPGD gene related products
-
Recommended
- Applied Biological Materials CRISPR for HPGD
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HPGD
- GenScript: Design CRISPR guide RNA sequences for HPGD
miRNA Products
- Search ViGene Biosciences for HPGD
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for HPGD
- Browse OriGene Inhibitory RNA Products For HPGD
- genomics-online: shRNA clones - Search results for 137 available HPGD gene related products
- Overview of 137 available HPGD gene related products
-
Recommended
-
ViGene Biosciences ready-to-package AAV shRNAs for HPGD gene
Clone Products
-
OriGene ORF clones in human for HPGD
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HPGD
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for HPGD
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HPGD
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for HPGD
- genomics-online: cdna clones - Search results for 137 available HPGD gene related products
- Overview of 137 available HPGD gene related products
-
Recommended
- orf clones - Search results for 137 available HPGD gene related products
- Overview of 137 available HPGD gene related products
-
Recommended
- Applied Biological Materials Clones for HPGD
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | |||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||||
SP6: | - |
Expression for HPGD Gene
mRNA differential expression in normal tissues according to GTEx for HPGD Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HPGD Gene
NURSA nuclear receptor signaling pathways regulating expression of HPGD Gene:
HPGDSOURCE GeneReport for Unigene cluster for HPGD Gene:
Hs.596913mRNA Expression by UniProt/SwissProt for HPGD Gene:
P15428-PGDH_HUMANEvidence on tissue expression from TISSUES for HPGD Gene
- Intestine(4.8)
- Pancreas(4.3)
- Lung(3.8)
- Nervous system(3.5)
- Skin(3.1)
- Stomach(2.7)
- Kidney(2.6)
- Liver(2.5)
Phenotype-based relationships between genes and organs from Gene ORGANizer for HPGD Gene
- ectoderm
- mesoderm
- cardiovascular
- digestive
- immune
- integumentary
- lymphatic
- skeletal muscle
- skeleton
- ear
- eye
- eyelid
- face
- head
- jaw
- lip
- mandible
- maxilla
- mouth
- neck
- scalp
- skull
- chest wall
- clavicle
- heart
- rib
- rib cage
- scapula
- sternum
- pelvis
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- nail
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
- blood
- blood vessel
- bone marrow
- hair
- skin
- spinal column
- sweat gland
- vertebrae
Primer Products
-
OriGene qPCR primer pairs for HPGD
-
OriGene qPCR primer pairs and template standards for HPGD
- genomics-online: primer clones - Search results for 137 available HPGD gene related products
- Overview of 137 available HPGD gene related products
-
Recommended
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for HPGD Gene
Orthologs for HPGD Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | HPGD 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | HPGD 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | HPGD 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Hpgd 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Hpgd 33 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
-- 34 |
|
OneToMany | |||
oppossum (Monodelphis domestica) |
Mammalia | HPGD 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | HPGD 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | HPGD 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | hpgd 33 |
|
||
Str.8168 33 |
|
||||
zebrafish (Danio rerio) |
Actinopterygii | LOC565975 33 |
|
||
CU928070.1 34 |
|
OneToOne | |||
rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6946 33 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001753 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | CG4842 35 34 |
|
||
Pdh 35 34 |
|
||||
CG18814 34 |
|
OneToMany | |||
Fbp2 34 |
|
OneToMany | |||
Adhr 34 |
|
OneToMany | |||
Adh 34 |
|
OneToMany |
- Species where no ortholog for HPGD was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HPGD Gene
(6) SIMAP similar genes for HPGD Gene using alignment to 6 proteins:
Variants for HPGD Gene
SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1050145 | benign, Pachydermoperiostosis syndrome, Digital clubbing, isolated congenital | 174,522,005(-) | C/T | 5_prime_UTR_variant, coding_sequence_variant, non_coding_transcript_variant, synonymous_variant | |
rs1056279271 | uncertain-significance, Pachydermoperiostosis syndrome, Digital clubbing, isolated congenital | 174,490,478(-) | G/A | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
rs116796476 | uncertain-significance, Pachydermoperiostosis syndrome, Digital clubbing, isolated congenital | 174,522,672(-) | C/G/T | 5_prime_UTR_variant, non_coding_transcript_variant | |
rs117270501 | uncertain-significance, Pachydermoperiostosis syndrome, Digital clubbing, isolated congenital | 174,492,077(-) | T/C | 3_prime_UTR_variant, coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, synonymous_variant | |
rs121434480 | pathogenic, Cranioosteoarthropathy, Pachydermoperiostosis syndrome, Cranioosteoarthropathy (COA) [MIM:259100] | 174,508,699(-) | C/G | coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant |
Additional Variant Information for HPGD Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HPGD Gene
Disorders for HPGD Gene

(8) MalaCards diseases for HPGD Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
Disorder | Aliases | PubMed IDs |
---|---|---|
digital clubbing, isolated congenital |
|
|
hypertrophic osteoarthropathy, primary, autosomal recessive, 1 |
|
|
primary hypertrophic osteoarthropathy |
|
|
acroosteolysis |
|
|
apocrine adenocarcinoma |
|
|
UniProtKB/Swiss-Prot
PGDH_HUMAN- Cranioosteoarthropathy (COA) [MIM:259100]: A form of osteoarthropathy characterized by swelling of the joints, digital clubbing, hyperhidrosis, delayed closure of the fontanels, periostosis, and variable patent ductus arteriosus. Pachydermia is not a prominent feature. {ECO:0000269 PubMed:18500342}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Hypertrophic osteoarthropathy, primary, autosomal recessive, 1 (PHOAR1) [MIM:259100]: A disease characterized by digital clubbing, periostosis, acroosteolysis, painful joint enlargement, and variable features of pachydermia that include thickened facial skin and a thickened scalp. Other developmental anomalies include delayed closure of the cranial sutures and congenital heart disease. {ECO:0000269 PubMed:18500342}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Isolated congenital nail clubbing (ICNC) [MIM:119900]: A rare genodermatosis characterized by enlargement of the nail plate and terminal segments of the fingers and toes, resulting from proliferation of the connective tissues between the nail matrix and the distal phalanx. It is usually symmetrical and bilateral (in some cases unilateral). In nail clubbing usually the distal end of the nail matrix is relatively high compared to the proximal end, while the nail plate is complete but its dimensions and diameter more or less vary in comparison to normal. There may be different fingers and toes involved to varying degrees. Some fingers or toes are spared, but the thumbs are almost always involved. {ECO:0000269 PubMed:18805827}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for HPGD
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for HPGD Gene
Publications for HPGD Gene
- Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma. (PMID: 20086108) Poole EM … Ulrich CM (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 22 44 58
- Mutation in the HPGD gene encoding NAD+ dependent 15-hydroxyprostaglandin dehydrogenase underlies isolated congenital nail clubbing (ICNC). (PMID: 18805827) Tariq M … Ahmad W (Journal of medical genetics 2009) 3 4 22 58
- Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy. (PMID: 18500342) Uppal S … Bonthron DT (Nature genetics 2008) 3 4 22 58
- Role of glutamine 148 of human 15-hydroxyprostaglandin dehydrogenase in catalytic oxidation of prostaglandin E2. (PMID: 16828555) Cho H … Tai HH (Bioorganic & medicinal chemistry 2006) 3 4 22 58
- 15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers. (PMID: 15574495) Yan M … Markowitz SD (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 22 58
Products for HPGD Gene
- R&D Systems Antibodies for HPGD (15-PGDH/HPGD)
- R&D Systems Proteins and Enzymes for HPGD (15-PGDH/HPGD)
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for HPGD
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HPGD
- Search Origene for MassSpec and Protein Over-expression Lysates for HPGD
- Origene Custom Protein Services for HPGD
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HPGD
- Browse OriGene Inhibitory RNA Products For HPGD
- OriGene qPCR primer pairs and template standards for HPGD
- OriGene qPCR primer pairs for HPGD
- OriGene CRISPR knockouts for HPGD
- OriGene ORF clones in human for HPGD
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HPGD
- GenScript: Next-day shipping of latest version cDNA ORF clones for HPGD in any vector
- GenScript Custom Purified and Recombinant Proteins Services for HPGD
- GenScript Custom Assay Services for HPGD
- GenScript Custom overexpressing Cell Line Services for HPGD
- GenScript: Design CRISPR guide RNA sequences for HPGD
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for HPGD
- Sino Biological Human cDNA Clone for HPGD
- Sino Biological Recombinant Proteins for HPGD
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for HPGD
- Sino Biological Assays for HPGD
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for HPGD
- Novus Biologicals proteins and lysates for HPGD
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for HPGD
- Abcam proteins for HPGD
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for HPGD
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for HPGD
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for HPGD
- VectorBuilder custom plasmid, inducible vectors for HPGD
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HPGD
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for HPGD
- antibodies-online: Search results for 127 available HPGD Antibodies ranked by validation data
- Compare Top HPGD Antibodies
- Quality Products:
- antibodies-online: Search results for 17 available HPGD Elisa Kits ranked by validation data
- Compare Top HPGD Elisa Kits
- antibodies-online: Search results for 18 available HPGD Proteins ranked by validation data
- Compare Top HPGD Proteins
- GeneTex HPGD antibody for HPGD
- Search GeneTex for Proteins for HPGD
- ViGene Biosciences adenoviral particle packaged cDNA for HPGD gene
- ViGene Biosciences lentiviral particle packaged cDNA for HPGD gene
- ViGene Biosciences ready-to-package AAV shRNAs for HPGD gene
- Search ViGene Biosciences for HPGD
- Santa Cruz Biotechnology (SCBT) Antibodies for HPGD
- Search Santa Cruz Biotechnology (SCBT) for HPGD siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HPGD
- Search for HPGD Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for HPGD
- Horizon Cell Lines for HPGD
- genomics-online: cdna clones - Search results for 137 available HPGD gene related products
- Overview of 137 available HPGD gene related products
- Recommended
- orf clones - Search results for 137 available HPGD gene related products
- Overview of 137 available HPGD gene related products
- Recommended
- genomics-online: gRNA clones - Search results for 137 available HPGD gene related products
- Overview of 137 available HPGD gene related products
- Recommended
- genomics-online: primer clones - Search results for 137 available HPGD gene related products
- Overview of 137 available HPGD gene related products
- Recommended
- genomics-online: shRNA clones - Search results for 137 available HPGD gene related products
- Overview of 137 available HPGD gene related products
- Recommended
Sources for HPGD Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew