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Aliases for HPF1 Gene

Aliases for HPF1 Gene

  • Histone PARylation Factor 1 2 3 5
  • C4orf27 3 4
  • Chromosome 4 Open Reading Frame 27 2
  • UPF0609 Protein C4orf27 3

External Ids for HPF1 Gene

Previous HGNC Symbols for HPF1 Gene

  • C4orf27

Summaries for HPF1 Gene

GeneCards Summary for HPF1 Gene

HPF1 (Histone PARylation Factor 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for HPF1 Gene

  • Key regulator of PARP1-dependent ADP-ribosylation signaling, acting to promote histone ADP-ribosylation, limit DNA damage-induced PARP1 hyper-automodification, and ensure genome stability (PubMed:27067600).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HPF1 Gene

Genomics for HPF1 Gene

Regulatory Elements for HPF1 Gene

Enhancers for HPF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F168877 1.5 FANTOM5 Ensembl ENCODE 13.6 +874.9 874906 11.6 HDGF ZNF493 ZFP64 RARA EGR1 FOS ZNF202 ZNF680 ZNF654 ZBTB11 CBR4 HPF1 PALLD ENSG00000249609 ENSG00000251445 RNY4P17 RNU6-1336P ENSG00000249623 RNU6-853P LOC102723331
GH04F169756 1.1 ENCODE 15 +0.2 203 2.0 ATF1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF48 ZNF2 ETS1 YY1 HPF1 GC04P169721
GH04F169248 1.2 Ensembl ENCODE 9.7 +504.6 504623 10.1 PKNOX1 ARID4B FEZF1 YY1 FOS ZNF202 ZNF263 PPARG SMARCA4 ZNF585B LOC105377528 SH3RF1 HPF1
GH04F169774 0.7 Ensembl 0.3 -17.0 -17048 0.8 CTCF CBX3 RNF2 L3MBTL2 ZBTB11 ZBTB7A GABPA SMARCA4 ZBTB33 E2F6 GC04M169780 HPF1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HPF1 on UCSC Golden Path with GeneCards custom track

Promoters for HPF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001437437 153 2000 ATF1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF48 ZNF2 ETS1 YY1

Genomic Location for HPF1 Gene

Chromosome:
4
Start:
169,729,465 bp from pter
End:
169,757,953 bp from pter
Size:
28,489 bases
Orientation:
Minus strand

Genomic View for HPF1 Gene

Genes around HPF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HPF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HPF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HPF1 Gene

Proteins for HPF1 Gene

  • Protein details for HPF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWY4-HPF1_HUMAN
    Recommended name:
    Histone PARylation factor 1
    Protein Accession:
    Q9NWY4

    Protein attributes for HPF1 Gene

    Size:
    346 amino acids
    Molecular mass:
    39436 Da
    Quaternary structure:
    • Interacts with PARP1 (via the PARP catalytic domain). Interacts with histone H2A and histone H3 in a PARP1-dependent manner. Weakly interacts with PARP2 (via the PARP catalytic domain) (PubMed:27067600).

neXtProt entry for HPF1 Gene

Post-translational modifications for HPF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HPF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HPF1 Gene

Domains & Families for HPF1 Gene

Protein Domains for HPF1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HPF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NWY4

UniProtKB/Swiss-Prot:

HPF1_HUMAN :
  • Belongs to the HPF1 family.
Family:
  • Belongs to the HPF1 family.
genes like me logo Genes that share domains with HPF1: view

No data available for Gene Families for HPF1 Gene

Function for HPF1 Gene

Molecular function for HPF1 Gene

UniProtKB/Swiss-Prot Function:
Key regulator of PARP1-dependent ADP-ribosylation signaling, acting to promote histone ADP-ribosylation, limit DNA damage-induced PARP1 hyper-automodification, and ensure genome stability (PubMed:27067600).

Gene Ontology (GO) - Molecular Function for HPF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27067600
GO:0042393 histone binding IDA 27067600
genes like me logo Genes that share ontologies with HPF1: view
genes like me logo Genes that share phenotypes with HPF1: view

Animal Model Products

miRNA for HPF1 Gene

miRTarBase miRNAs that target HPF1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HPF1 Gene

Localization for HPF1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HPF1 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for HPF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with HPF1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HPF1 Gene

Pathways & Interactions for HPF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HPF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006974 cellular response to DNA damage stimulus IMP 27067600
GO:0010835 regulation of protein ADP-ribosylation IMP 27067600
genes like me logo Genes that share ontologies with HPF1: view

No data available for Pathways by source and SIGNOR curated interactions for HPF1 Gene

Transcripts for HPF1 Gene

mRNA/cDNA for HPF1 Gene

Unigene Clusters for HPF1 Gene

Chromosome 4 open reading frame 27:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HPF1 Gene

No ASD Table

Relevant External Links for HPF1 Gene

GeneLoc Exon Structure for
HPF1
ECgene alternative splicing isoforms for
HPF1

Expression for HPF1 Gene

NURSA nuclear receptor signaling pathways regulating expression of HPF1 Gene:

HPF1

SOURCE GeneReport for Unigene cluster for HPF1 Gene:

Hs.406756
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for HPF1 Gene

Orthologs for HPF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HPF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C4H4orf27 34
  • 99.33 (n)
C4orf27 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C4ORF27 35
  • 93 (a)
OneToOne
C25H4orf27 34
  • 92.73 (n)
mouse
(Mus musculus)
Mammalia 2700029M09Rik 34 35
  • 90.06 (n)
Hpf1 16
rat
(Rattus norvegicus)
Mammalia RGD1311747 34
  • 87.95 (n)
cow
(Bos Taurus)
Mammalia C8H4orf27 34
  • 86.22 (n)
C4orf27 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C4orf27 35
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C4orf27 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves C4H4ORF27 34
  • 74.57 (n)
C4orf27 35
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C4orf27 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488348 34
  • 69.4 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:101819 34
  • 64.95 (n)
C1H4orf27 35
  • 63 (a)
OneToOne
wufb44b08 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010317 34
  • 47.68 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1218 34 35
  • 47.03 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 44 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13723 34
Species where no ortholog for HPF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HPF1 Gene

ENSEMBL:
Gene Tree for HPF1 (if available)
TreeFam:
Gene Tree for HPF1 (if available)

Paralogs for HPF1 Gene

Pseudogenes.org Pseudogenes for HPF1 Gene

genes like me logo Genes that share paralogs with HPF1: view

No data available for Paralogs for HPF1 Gene

Variants for HPF1 Gene

Sequence variations from dbSNP and Humsavar for HPF1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10001076 -- 169,742,618(+) AAACC(C/T)CGTCT intron-variant
rs10012711 -- 169,742,608(+) TAACA(A/C/T)GGTGA intron-variant
rs10016129 -- 169,752,695(+) TAAAA(C/T)AATGA intron-variant
rs10016639 -- 169,753,185(+) tgcac(C/T)accat intron-variant
rs10018221 -- 169,743,626(+) ACTTA(C/T)GGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HPF1 Gene

Variant ID Type Subtype PubMed ID
nsv964113 CNV duplication 23825009
esv3603125 CNV loss 21293372
esv3351919 CNV insertion 20981092

Variation tolerance for HPF1 Gene

Residual Variation Intolerance Score: 62.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HPF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HPF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HPF1 Gene

Disorders for HPF1 Gene

Relevant External Links for HPF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HPF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HPF1

No disorders were found for HPF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HPF1 Gene

Publications for HPF1 Gene

  1. HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity. (PMID: 27067600) Gibbs-Seymour I. … Ahel I. (Mol. Cell 2016) 2 3 4 64
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for HPF1 Gene

Sources for HPF1 Gene

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