Aliases for HPF1 Gene
Aliases for HPF1 Gene
External Ids for HPF1 Gene
- HGNC: 26051
- Entrez Gene: 54969
- Ensembl: ENSG00000056050
- OMIM: 616614
- UniProtKB: Q9NWY4
Previous HGNC Symbols for HPF1 Gene
- C4orf27
Summaries for HPF1 Gene
GeneCards Summary for HPF1 Gene
HPF1 (Histone PARylation Factor 1) is a Protein Coding gene.
UniProtKB/Swiss-Prot for HPF1 Gene
-
Acts as a cofactor for serine ADP-ribosylation by conferring serine specificity on PARP1 and PARP2: interacts with PARP1 and PARP1 and is able to change amino acid specificity toward serine (PubMed:28190768). Promotes histone serine ADP-ribosylation in response to DNA damage, limiting DNA damage-induced PARP1 hyper-automodification, and ensuring genome stability (PubMed:27067600, PubMed:28190768).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HPF1 Gene
Genomics for HPF1 Gene
Regulatory Elements for HPF1 Gene
Enhancers for HPF1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH04G168877 | 1.8 | FANTOM5 Ensembl ENCODE dbSUPER | 13.6 | +874.9 | 874906 | 11.6 | HDGF ZNF493 ZFP64 GATA2 FOS ZNF202 REST PPARG ZNF623 ZNF518A | CBR4 HPF1 PALLD ENSG00000249609 ENSG00000251445 RNY4P17 RNU6-1336P ENSG00000249623 RNU6-853P LOC102723331 |
| GH04G169266 | 1.8 | FANTOM5 Ensembl ENCODE dbSUPER | 10.5 | +488.1 | 488055 | 6.2 | PKNOX1 FOXA2 ARID4B SIN3A ZNF2 ZNF48 GLIS2 GATA2 ZNF143 FOS | SH3RF1 HPF1 ENSG00000251171 |
| GH04G168814 | 1.7 | FANTOM5 Ensembl ENCODE dbSUPER | 11 | +941.4 | 941399 | 3.6 | ZNF473 ZSCAN4 FEZF1 BMI1 ZNF2 RAD21 ZBTB7B ELK1 ZNF366 SCRT2 | HPF1 PIR54806 GC04P168775 |
| GH04G169756 | 1.1 | ENCODE | 14.9 | +0.2 | 203 | 2.0 | MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SP3 SP5 MXD4 | HPF1 GC04P169721 |
| GH04G169774 | 0.7 | Ensembl | 0.4 | -17.0 | -17048 | 0.8 | CTCF CBX3 MTA2 RNF2 L3MBTL2 ZBTB11 ZBTB40 ZBTB7A GABPA SMARCA4 | GC04M169780 HPF1 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HPF1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for HPF1 Gene
- Chromosome:
- 4
- Start:
- 169,729,465 bp from pter
- End:
- 169,757,953 bp from pter
- Size:
- 28,489 bases
- Orientation:
- Minus strand
Genomic View for HPF1 Gene
Genes around HPF1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q33 by Ensembl
- 4q33 by Entrez Gene
- 4q33 by HGNC
HPF1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HPF1 Gene
Proteins for HPF1 Gene
-
Protein details for HPF1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NWY4-HPF1_HUMAN
- Recommended name:
- Histone PARylation factor 1
- Protein Accession:
- Q9NWY4
Protein attributes for HPF1 Gene
- Size:
- 346 amino acids
- Molecular mass:
- 39436 Da
- Quaternary structure:
-
- Interacts with PARP1 (via the PARP catalytic domain) (PubMed:27067600). Interacts with histone H2A and histone H3 in a PARP1-dependent manner (PubMed:27067600). Weakly interacts with PARP2 (via the PARP catalytic domain) (PubMed:27067600).
Post-translational modifications for HPF1 Gene
Other Protein References for HPF1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for HPF1
- Novus Biologicals Antibodies for HPF1
-
Abcam antibodies for HPF1
- Invitrogen Antibodies for HPF1
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Protein Products
-
OriGene Purified Proteins for HPF1
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- Search GeneTex for Proteins for HPF1
Assay Products
No data available for DME Specific Peptides for HPF1 Gene
Domains & Families for HPF1 Gene
Suggested Antigen Peptide Sequences for HPF1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9NWY4- Family:
-
- Belongs to the HPF1 family.
No data available for Gene Families for HPF1 Gene
Function for HPF1 Gene
Molecular function for HPF1 Gene
- UniProtKB/Swiss-Prot Function:
- Acts as a cofactor for serine ADP-ribosylation by conferring serine specificity on PARP1 and PARP2: interacts with PARP1 and PARP1 and is able to change amino acid specificity toward serine (PubMed:28190768). Promotes histone serine ADP-ribosylation in response to DNA damage, limiting DNA damage-induced PARP1 hyper-automodification, and ensuring genome stability (PubMed:27067600, PubMed:28190768).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 27067600 |
| GO:0042393 | histone binding | IDA | 27067600 |
Phenotypes for HPF1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HPF1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HPF1 gene
- Search ViGene Biosciences for HPF1
CRISPR Products
-
OriGene CRISPR knockouts for HPF1
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miRNA for HPF1 Gene
- miRTarBase miRNAs that target HPF1
miRNA Products
- Search ViGene Biosciences for HPF1
Inhibitory RNA Products
- Origene siRNA, shRNA, and RNAi products in human, mouse, rat for HPF1
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-
ViGene Biosciences ready-to-package AAV shRNAs for HPF1 gene
Cell Line Products
-
Horizon Cell Lines for HPF1
-
ViGene Biosciences adenoviral particle packaged cDNA for HPF1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HPF1 gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HPF1 Gene
Localization for HPF1 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| cytoskeleton | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for HPF1 Gene
Pathways & Interactions for HPF1 Gene
No Data Available
Interacting Proteins for HPF1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006974 | cellular response to DNA damage stimulus | IMP | 27067600 |
| GO:0010835 | regulation of protein ADP-ribosylation | IMP | 27067600 |
| GO:0018312 | peptidyl-serine ADP-ribosylation | IDA | 28190768 |
No data available for Pathways by source and SIGNOR curated interactions for HPF1 Gene
Transcripts for HPF1 Gene
mRNA/cDNA for HPF1 Gene
- (2) REFSEQ mRNAs :
- (121) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HPF1
- GenScript: Design CRISPR guide RNA sequences for HPF1
miRNA Products
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Inhibitory RNA Products
- Origene siRNA, shRNA, and RNAi products in human, mouse, rat for HPF1
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-
ViGene Biosciences ready-to-package AAV shRNAs for HPF1 gene
Flow Cytometry Products
Expression for HPF1 Gene
NURSA nuclear receptor signaling pathways regulating expression of HPF1 Gene:
HPF1Evidence on tissue expression from TISSUES for HPF1 Gene
- Nervous system(4.3)
- Skin(4.2)
No Expression Related Data Available
Primer Products
-
OriGene qPCR primer pairs for HPF1
-
OriGene qPCR primer pairs and template standards for HPF1
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HPF1 Gene
Orthologs for HPF1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | C4H4orf27 34 |
|
||
| C4orf27 35 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | C4ORF27 35 |
|
OneToOne | |
| C25H4orf27 34 |
|
||||
| mouse (Mus musculus) |
Mammalia | 2700029M09Rik 34 35 |
|
||
| Hpf1 16 |
|
||||
| rat (Rattus norvegicus) |
Mammalia | RGD1311747 34 |
|
||
| cow (Bos Taurus) |
Mammalia | C8H4orf27 34 |
|
||
| C4orf27 35 |
|
OneToOne | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | C4orf27 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | C4orf27 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | C4H4ORF27 34 |
|
||
| C4orf27 35 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | C4orf27 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100488348 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | zgc:101819 34 |
|
||
| C1H4orf27 35 |
|
OneToOne | |||
| wufb44b08 34 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010317 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG1218 34 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.13723 34 |
|
- Species where no ortholog for HPF1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HPF1 Gene
Pseudogenes.org Pseudogenes for HPF1 Gene
No data available for Paralogs for HPF1 Gene
Variants for HPF1 Gene
| SNP ID | Clin | Chr 04 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs10001076 | -- | 169,742,618(+) | AAACC(C/T)CGTCT | intron-variant | |
| rs1000254589 | -- | 169,731,449(+) | AATGC(A/G)AATAA | intron-variant, utr-variant-3-prime | |
| rs1000429053 | -- | 169,737,904(+) | CACTA(A/T)TTTTT | intron-variant | |
| rs1000671257 | -- | 169,736,815(+) | GTTCA(C/T)GATAA | intron-variant | |
| rs1000765703 | -- | 169,736,573(+) | CTCTG(C/T)ACAGT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3351919 | CNV | insertion | 20981092 |
| esv3603125 | CNV | loss | 21293372 |
| nsv964113 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
62.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.56;
30.12% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HPF1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HPF1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HPF1 Gene
Disorders for HPF1 Gene
Relevant External Links for HPF1
No disorders were found for HPF1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HPF1 Gene
Publications for HPF1 Gene
- HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity. (PMID: 27067600) Gibbs-Seymour I. … Ahel I. (Mol. Cell 2016) 2 3 4 64
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 64
- Serine ADP-ribosylation depends on HPF1. (PMID: 28190768) Bonfiglio J.J. … Matic I. (Mol. Cell 2017) 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- SERious Surprises for ADP-Ribosylation Specificity: HPF1 Switches PARP1 Specificity to Ser Residues. (PMID: 28257697) Leung A.K. (Mol. Cell 2017) 3 64
Products for HPF1 Gene
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- Custom Antibody ServicesOriGene Antibodies for HPF1
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- OriGene qPCR primer pairs and template standards for HPF1
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- Novus Biologicals Antibodies for HPF1
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- VectorBuilder custom plasmid, inducible vectors for HPF1
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
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- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HPF1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
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- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
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- (133) NCBI Bookshelf
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- (136) ViGene Biosciences
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- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer