Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HPF1 Gene

Aliases for HPF1 Gene

  • Histone PARylation Factor 1 2 3
  • C4orf27 3 4 5
  • Chromosome 4 Open Reading Frame 27 2 5

External Ids for HPF1 Gene

Previous HGNC Symbols for HPF1 Gene

  • C4orf27

Summaries for HPF1 Gene

GeneCards Summary for HPF1 Gene

HPF1 (Histone PARylation Factor 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HPF1 Gene

Genomics for HPF1 Gene

Regulatory Elements for HPF1 Gene

Enhancers for HPF1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HPF1 on UCSC Golden Path with GeneCards custom track

Promoters for HPF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HPF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for HPF1 Gene

169,729,465 bp from pter
169,757,953 bp from pter
28,489 bases
Minus strand

Genomic View for HPF1 Gene

Genes around HPF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HPF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HPF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HPF1 Gene

Proteins for HPF1 Gene

  • Protein details for HPF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UPF0609 protein C4orf27
    Protein Accession:

    Protein attributes for HPF1 Gene

    346 amino acids
    Molecular mass:
    39436 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HPF1 Gene

Proteomics data for HPF1 Gene at MOPED

Post-translational modifications for HPF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HPF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HPF1 Gene

Domains & Families for HPF1 Gene

Protein Domains for HPF1 Gene


Suggested Antigen Peptide Sequences for HPF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0609 family.
  • Belongs to the UPF0609 family.
genes like me logo Genes that share domains with HPF1: view

No data available for Gene Families for HPF1 Gene

Function for HPF1 Gene

genes like me logo Genes that share phenotypes with HPF1: view

Animal Model Products

miRNA for HPF1 Gene

miRTarBase miRNAs that target HPF1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HPF1 Gene

Localization for HPF1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for HPF1 Gene

Pathways & Interactions for HPF1 Gene

SuperPathways for HPF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HPF1 Gene


No data available for Pathways by source and SIGNOR curated interactions for HPF1 Gene

Drugs & Compounds for HPF1 Gene

No Compound Related Data Available

Transcripts for HPF1 Gene

mRNA/cDNA for HPF1 Gene

Unigene Clusters for HPF1 Gene

Chromosome 4 open reading frame 27:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HPF1 Gene

No ASD Table

Relevant External Links for HPF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HPF1 Gene

SOURCE GeneReport for Unigene cluster for HPF1 Gene Hs.406756

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for HPF1 Gene

Orthologs for HPF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HPF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C8H4orf27 35
  • 86.22 (n)
  • 85.55 (a)
C4orf27 36
  • 86 (a)
(Canis familiaris)
Mammalia C25H4orf27 35
  • 92.73 (n)
  • 93.64 (a)
C4ORF27 36
  • 93 (a)
(Mus musculus)
Mammalia 2700029M09Rik 35
  • 90.06 (n)
  • 89.76 (a)
2700029M09Rik 16
2700029M09Rik 36
  • 89 (a)
(Pan troglodytes)
Mammalia C4H4orf27 35
  • 99.33 (n)
  • 98.84 (a)
C4orf27 36
  • 99 (a)
(Rattus norvegicus)
Mammalia RGD1311747 35
  • 87.95 (n)
  • 88.25 (a)
(Monodelphis domestica)
Mammalia C4orf27 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia C4orf27 36
  • 84 (a)
(Gallus gallus)
Aves C4H4ORF27 35
  • 74.57 (n)
  • 75.99 (a)
C4orf27 36
  • 74 (a)
(Anolis carolinensis)
Reptilia C4orf27 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488348 35
  • 69.4 (n)
  • 68.09 (a)
(Danio rerio)
Actinopterygii wufb44b08 35
zgc:101819 35
  • 64.95 (n)
  • 64.85 (a)
C1H4orf27 36
  • 63 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010317 35
  • 47.68 (n)
  • 37.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1218 35
  • 47.03 (n)
  • 39.04 (a)
CG1218 36
  • 27 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13723 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
Species with no ortholog for HPF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HPF1 Gene

Gene Tree for HPF1 (if available)
Gene Tree for HPF1 (if available)

Paralogs for HPF1 Gene Pseudogenes for HPF1 Gene

genes like me logo Genes that share paralogs with HPF1: view

No data available for Paralogs for HPF1 Gene

Variants for HPF1 Gene

Sequence variations from dbSNP and Humsavar for HPF1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1047642 -- 169,742,084(-) ACTTA(A/G)AGAAA reference, missense
rs1047673 -- 169,731,827(-) GATGA(G/T)GAGAG reference, missense
rs1047688 -- 169,731,749(-) TATGG(C/T)ATGGG reference, synonymous-codon
rs1047706 -- 169,729,626(-) GAGGA(A/G/T)CATCT reference, synonymous-codon, missense
rs1047716 -- 169,729,608(-) AGAAG(A/T)CAAGA reference, missense

Variation tolerance for HPF1 Gene

Residual Variation Intolerance Score: 62.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HPF1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HPF1 Gene

Disorders for HPF1 Gene

Relevant External Links for HPF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HPF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HPF1 Gene

Publications for HPF1 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity. (PMID: 27067600) Gibbs-Seymour I. … Ahel I. (Mol. Cell 2016) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3

Products for HPF1 Gene

Sources for HPF1 Gene