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Aliases for HPF1 Gene

Aliases for HPF1 Gene

  • Histone PARylation Factor 1 2 3 5
  • C4orf27 3 4
  • Chromosome 4 Open Reading Frame 27 2
  • UPF0609 Protein C4orf27 3

External Ids for HPF1 Gene

Previous HGNC Symbols for HPF1 Gene

  • C4orf27

Summaries for HPF1 Gene

GeneCards Summary for HPF1 Gene

HPF1 (Histone PARylation Factor 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for HPF1 Gene

  • Acts as a cofactor for serine ADP-ribosylation by conferring serine specificity on PARP1 and PARP2: interacts with PARP1 and PARP1 and is able to change amino acid specificity toward serine (PubMed:28190768). Promotes histone serine ADP-ribosylation in response to DNA damage, limiting DNA damage-induced PARP1 hyper-automodification, and ensuring genome stability (PubMed:27067600, PubMed:28190768).

Additional gene information for HPF1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HPF1 Gene

Genomics for HPF1 Gene

Regulatory Elements for HPF1 Gene

Enhancers for HPF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H169266 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +488.1 488055 6 PKNOX1 FOXA2 ARID4B SIN3A ZNF2 GLIS2 ZNF143 FOS ATF7 RUNX3 SH3RF1 HPF1 ENSG00000251171
GH04H168814 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.1 +941.4 941399 3 ZNF473 ZSCAN4 FEZF1 BMI1 ZNF2 RAD21 ZBTB7B ELK1 ZNF366 SCRT2 HPF1 PIR54806 GC04P168775
GH04H169756 1.1 ENCODE 15 +0.2 203 1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SP3 SP5 MXD4 REST HPF1 GC04P169721
GH04H169774 0.6 Ensembl 0.4 -17.0 -17048 0 CTCF MTA2 L3MBTL2 SMARCA4 ZBTB11 ZBTB33 ZBTB40 MGA GC04M169780 HPF1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HPF1 on UCSC Golden Path with GeneCards custom track

Promoters for HPF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000176093 253 1800 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 SP3 SP5 MXD4

Genomic Location for HPF1 Gene

Chromosome:
4
Start:
169,729,465 bp from pter
End:
169,757,953 bp from pter
Size:
28,489 bases
Orientation:
Minus strand

Genomic View for HPF1 Gene

Genes around HPF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HPF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HPF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HPF1 Gene

Proteins for HPF1 Gene

  • Protein details for HPF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWY4-HPF1_HUMAN
    Recommended name:
    Histone PARylation factor 1
    Protein Accession:
    Q9NWY4

    Protein attributes for HPF1 Gene

    Size:
    346 amino acids
    Molecular mass:
    39436 Da
    Quaternary structure:
    • Interacts with PARP1 (via the PARP catalytic domain) (PubMed:27067600). Interacts with histone H2A and histone H3 in a PARP1-dependent manner (PubMed:27067600). Weakly interacts with PARP2 (via the PARP catalytic domain) (PubMed:27067600).

neXtProt entry for HPF1 Gene

Post-translational modifications for HPF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HPF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HPF1 Gene

Domains & Families for HPF1 Gene

Gene Families for HPF1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HPF1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HPF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NWY4

UniProtKB/Swiss-Prot:

HPF1_HUMAN :
  • Belongs to the HPF1 family.
Family:
  • Belongs to the HPF1 family.
genes like me logo Genes that share domains with HPF1: view

Function for HPF1 Gene

Molecular function for HPF1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a cofactor for serine ADP-ribosylation by conferring serine specificity on PARP1 and PARP2: interacts with PARP1 and PARP1 and is able to change amino acid specificity toward serine (PubMed:28190768). Promotes histone serine ADP-ribosylation in response to DNA damage, limiting DNA damage-induced PARP1 hyper-automodification, and ensuring genome stability (PubMed:27067600, PubMed:28190768).

Gene Ontology (GO) - Molecular Function for HPF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27067600
GO:0042393 histone binding IDA 27067600
genes like me logo Genes that share ontologies with HPF1: view
genes like me logo Genes that share phenotypes with HPF1: view

Animal Model Products

CRISPR Products

miRNA for HPF1 Gene

miRTarBase miRNAs that target HPF1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HPF1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HPF1 Gene

Localization for HPF1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HPF1 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (2)
  • Cytosol (2)
  • Microtubules (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HPF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with HPF1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HPF1 Gene

Pathways & Interactions for HPF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HPF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006974 cellular response to DNA damage stimulus IMP 27067600
GO:0010835 regulation of protein ADP-ribosylation IMP 27067600
GO:0018312 peptidyl-serine ADP-ribosylation IDA 28190768
genes like me logo Genes that share ontologies with HPF1: view

No data available for Pathways by source and SIGNOR curated interactions for HPF1 Gene

Drugs & Compounds for HPF1 Gene

No Compound Related Data Available

Transcripts for HPF1 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HPF1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for HPF1 Gene

No ASD Table

Relevant External Links for HPF1 Gene

GeneLoc Exon Structure for
HPF1
ECgene alternative splicing isoforms for
HPF1

Expression for HPF1 Gene

NURSA nuclear receptor signaling pathways regulating expression of HPF1 Gene:

HPF1

Evidence on tissue expression from TISSUES for HPF1 Gene

  • Nervous system(4.3)
  • Skin(4.2)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HPF1 Gene

Orthologs for HPF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HPF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C4H4orf27 33
  • 99.33 (n)
C4orf27 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C4ORF27 34
  • 93 (a)
OneToOne
C25H4orf27 33
  • 92.73 (n)
mouse
(Mus musculus)
Mammalia 2700029M09Rik 33 34
  • 90.06 (n)
Hpf1 16
rat
(Rattus norvegicus)
Mammalia RGD1311747 33
  • 87.95 (n)
cow
(Bos Taurus)
Mammalia C8H4orf27 33
  • 86.22 (n)
C4orf27 34
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C4orf27 34
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C4orf27 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves C4H4ORF27 33
  • 74.57 (n)
C4orf27 34
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C4orf27 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488348 33
  • 69.4 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:101819 33
  • 64.95 (n)
C1H4orf27 34
  • 63 (a)
OneToOne
wufb44b08 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010317 33
  • 47.68 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1218 33 34
  • 47.03 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 44 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13723 33
Species where no ortholog for HPF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HPF1 Gene

ENSEMBL:
Gene Tree for HPF1 (if available)
TreeFam:
Gene Tree for HPF1 (if available)

Paralogs for HPF1 Gene

Pseudogenes.org Pseudogenes for HPF1 Gene

genes like me logo Genes that share paralogs with HPF1: view

No data available for Paralogs for HPF1 Gene

Variants for HPF1 Gene

Sequence variations from dbSNP and Humsavar for HPF1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10001076 -- 169,742,618(+) AAACC(C/T)CGTCT intron-variant
rs1000254589 -- 169,731,449(+) AATGC(A/G)AATAA intron-variant, utr-variant-3-prime
rs1000429053 -- 169,737,904(+) CACTA(A/T)TTTTT intron-variant
rs1000671257 -- 169,736,815(+) GTTCA(C/T)GATAA intron-variant
rs1000765703 -- 169,736,573(+) CTCTG(C/T)ACAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HPF1 Gene

Variant ID Type Subtype PubMed ID
esv3351919 CNV insertion 20981092
esv3603125 CNV loss 21293372
nsv964113 CNV duplication 23825009

Variation tolerance for HPF1 Gene

Residual Variation Intolerance Score: 62.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HPF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HPF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HPF1 Gene

Disorders for HPF1 Gene

Relevant External Links for HPF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HPF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HPF1

No disorders were found for HPF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HPF1 Gene

Publications for HPF1 Gene

  1. HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity. (PMID: 27067600) Gibbs-Seymour I … Ahel I (Molecular cell 2016) 2 3 4 60
  2. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 60
  3. Serine ADP-Ribosylation Depends on HPF1. (PMID: 28190768) Bonfiglio JJ … Matic I (Molecular cell 2017) 3 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. SERious Surprises for ADP-Ribosylation Specificity: HPF1 Switches PARP1 Specificity to Ser Residues. (PMID: 28257697) Leung AK (Molecular cell 2017) 3 60

Products for HPF1 Gene

Sources for HPF1 Gene

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