Aliases for HPF1 Gene
External Ids for HPF1 Gene
Previous HGNC Symbols for HPF1 Gene
GeneCards Summary for HPF1 Gene
HPF1 (Histone PARylation Factor 1) is a Protein Coding gene.
UniProtKB/Swiss-Prot for HPF1 Gene
Acts as a cofactor for serine ADP-ribosylation by conferring serine specificity on PARP1 and PARP2: interacts with PARP1 and PARP1 and is able to change amino acid specificity toward serine (PubMed:28190768). Promotes histone serine ADP-ribosylation in response to DNA damage, limiting DNA damage-induced PARP1 hyper-automodification, and ensuring genome stability (PubMed:27067600, PubMed:28190768).