Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HPDL Gene

Aliases for HPDL Gene

  • 4-Hydroxyphenylpyruvate Dioxygenase-Like 2 3
  • Glyoxalase Domain-Containing Protein 1 3 4
  • Glyoxalase Domain Containing 1 2 3
  • GLOXD1 3 4
  • 4-Hydroxyphenylpyruvate Dioxygenase-Like Protein 3
  • EC 1.13.-.- 4
  • 4-HPPD-L 3

External Ids for HPDL Gene

Previous HGNC Symbols for HPDL Gene

  • GLOXD1

Previous GeneCards Identifiers for HPDL Gene

  • GC01P045568
  • GC01P045792
  • GC01P043905

Summaries for HPDL Gene

GeneCards Summary for HPDL Gene

HPDL (4-Hydroxyphenylpyruvate Dioxygenase-Like) is a Protein Coding gene. GO annotations related to this gene include 4-hydroxyphenylpyruvate dioxygenase activity. An important paralog of this gene is HPD.

UniProtKB/Swiss-Prot for HPDL Gene

  • May have dioxygenase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HPDL Gene

Genomics for HPDL Gene

Regulatory Elements for HPDL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HPDL Gene

45,326,873 bp from pter
45,328,675 bp from pter
1,803 bases
Plus strand

Genomic View for HPDL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HPDL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HPDL Gene

Proteins for HPDL Gene

  • Protein details for HPDL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    4-hydroxyphenylpyruvate dioxygenase-like protein
    Protein Accession:
    Secondary Accessions:
    • B2R9B0

    Protein attributes for HPDL Gene

    371 amino acids
    Molecular mass:
    39386 Da
    Name=Fe cation; Xref=ChEBI:CHEBI:24875; Note=Binds 1 Fe cation per subunit.;
    Quaternary structure:
    No Data Available

neXtProt entry for HPDL Gene

Proteomics data for HPDL Gene at MOPED

Post-translational modifications for HPDL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HPDL Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HPDL Gene

Domains for HPDL Gene

Protein Domains for HPDL Gene

Suggested Antigen Peptide Sequences for HPDL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96IR7
  • Belongs to the 4HPPD family.
genes like me logo Genes that share domains with HPDL: view

No data available for Gene Families for HPDL Gene

Function for HPDL Gene

Molecular function for HPDL Gene

UniProtKB/Swiss-Prot Function:
May have dioxygenase activity.

Enzyme Numbers (IUBMB) for HPDL Gene

Gene Ontology (GO) - Molecular Function for HPDL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity IEA --
GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with HPDL: view

Animal Model Products

miRNA for HPDL Gene

miRTarBase miRNAs that target HPDL

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HPDL

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HPDL Gene

Localization for HPDL Gene

Subcellular locations from

Jensen Localization Image for HPDL Gene COMPARTMENTS Subcellular localization image for HPDL gene
Compartment Confidence
mitochondrion 3
peroxisome 2
cytosol 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for HPDL Gene

Pathways for HPDL Gene

SuperPathways for HPDL Gene

No Data Available

Interacting Proteins for HPDL Gene

Gene Ontology (GO) - Biological Process for HPDL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009072 aromatic amino acid family metabolic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with HPDL: view

No data available for Pathways by source for HPDL Gene

Transcripts for HPDL Gene

mRNA/cDNA for HPDL Gene

(96) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HPDL Gene

4-hydroxyphenylpyruvate dioxygenase-like:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HPDL

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HPDL Gene

No ASD Table

Relevant External Links for HPDL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HPDL Gene

mRNA expression in normal human tissues for HPDL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HPDL Gene

This gene is overexpressed in Colon - Transverse (4.9).

Protein differential expression in normal tissues for HPDL Gene

This gene is overexpressed in Prostate (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HPDL Gene

SOURCE GeneReport for Unigene cluster for HPDL Gene Hs.162717

genes like me logo Genes that share expressions with HPDL: view

Expression partners for HPDL Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HPDL Gene

Orthologs for HPDL Gene

This gene was present in the common ancestor of animals.

Orthologs for HPDL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HPDL 35
  • 82.48 (n)
  • 84.91 (a)
  • 81 (a)
(Canis familiaris)
Mammalia HPDL 35
  • 83.83 (n)
  • 84.37 (a)
  • 78 (a)
(Mus musculus)
Mammalia Hpdl 35
  • 78.17 (n)
  • 78.71 (a)
Hpdl 16
Hpdl 36
  • 79 (a)
(Pan troglodytes)
Mammalia HPDL 35
  • 99.73 (n)
  • 99.73 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Hpdl 35
  • 78.05 (n)
  • 79.95 (a)
(Monodelphis domestica)
Mammalia HPDL 36
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 12 (a)
(Gallus gallus)
Aves HPDL 35
  • 62.36 (n)
  • 52.25 (a)
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hpdl 35
  • 49.34 (n)
  • 42.66 (a)
(Danio rerio)
Actinopterygii zgc:171978 35
  • 54.66 (n)
  • 44.69 (a)
  • 38 (a)
(Caenorhabditis elegans)
Secernentea C31H2.4 36
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2641 36
  • 29 (a)
Species with no ortholog for HPDL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HPDL Gene

Gene Tree for HPDL (if available)
Gene Tree for HPDL (if available)

Paralogs for HPDL Gene

Paralogs for HPDL Gene

genes like me logo Genes that share paralogs with HPDL: view

Variants for HPDL Gene

Sequence variations from dbSNP and Humsavar for HPDL Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs7535487 -- 45,325,517(+) agtgt(A/T)gctgg upstream-variant-2KB
rs10648456 -- 45,326,473(+) TAAAC(-/GT/GTGTGTGT)GTGTG upstream-variant-2KB
rs10890324 -- 45,325,482(+) CAGAG(A/G)CGTTA upstream-variant-2KB
rs11555591 -- 45,327,257(+) CTTCG(C/T)GGGAG reference, missense
rs34303761 -- 45,325,893(+) CTTCA(-/A)GGGCC upstream-variant-2KB

Relevant External Links for HPDL Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HPDL Gene

Disorders for HPDL Gene

No disorders were found for HPDL Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for HPDL Gene

Publications for HPDL Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. Glyoxalase I and aldose reductase gene polymorphisms and susceptibility to carotid atherosclerosis in type 2 diabetes. (PMID: 21294693) Wu J.C. … Peng Y.D. (Genet Test Mol Biomarkers 2011) 3
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for HPDL Gene

Sources for HPDL Gene

Back to Top