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Aliases for HPCAL4 Gene

Aliases for HPCAL4 Gene

  • Hippocalcin Like 4 2 3
  • HLP4 3 4
  • Hippocalcin-Like Protein 4 3

External Ids for HPCAL4 Gene

Previous GeneCards Identifiers for HPCAL4 Gene

  • GC01M040174
  • GC01M039148
  • GC01M039608
  • GC01M039557
  • GC01M039813
  • GC01M039916
  • GC01M038263

Summaries for HPCAL4 Gene

Entrez Gene Summary for HPCAL4 Gene

  • The protein encoded by this gene is highly similar to human hippocalcin protein and hippocalcin like-1 protein. It also has similarity to rat neural visinin-like Ca2+-binding protein-type 1 and 2 proteins. This encoded protein may be involved in the calcium-dependent regulation of rhodopsin phosphorylation. The transcript of this gene has multiple polyadenylation sites. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for HPCAL4 Gene

HPCAL4 (Hippocalcin Like 4) is a Protein Coding gene. Among its related pathways are Visual Cycle in Retinal Rods. GO annotations related to this gene include calcium ion binding and protein domain specific binding. An important paralog of this gene is KCNIP3.

UniProtKB/Swiss-Prot for HPCAL4 Gene

  • May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.

Gene Wiki entry for HPCAL4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HPCAL4 Gene

Genomics for HPCAL4 Gene

Regulatory Elements for HPCAL4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HPCAL4 Gene

Start:
39,678,648 bp from pter
End:
39,691,710 bp from pter
Size:
13,063 bases
Orientation:
Minus strand

Genomic View for HPCAL4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HPCAL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HPCAL4 Gene

Proteins for HPCAL4 Gene

  • Protein details for HPCAL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UM19-HPCL4_HUMAN
    Recommended name:
    Hippocalcin-like protein 4
    Protein Accession:
    Q9UM19
    Secondary Accessions:
    • B2R5U2
    • D3DPU1
    • Q5TG97
    • Q8N611

    Protein attributes for HPCAL4 Gene

    Size:
    191 amino acids
    Molecular mass:
    22202 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Probably binds two or three calcium ions.

neXtProt entry for HPCAL4 Gene

Proteomics data for HPCAL4 Gene at MOPED

Post-translational modifications for HPCAL4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HPCAL4 Gene

Antibody Products

No data available for DME Specific Peptides for HPCAL4 Gene

Domains for HPCAL4 Gene

Gene Families for HPCAL4 Gene

HGNC:
  • EFHAND :EF-hand domain containing

Protein Domains for HPCAL4 Gene

Suggested Antigen Peptide Sequences for HPCAL4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UM19

UniProtKB/Swiss-Prot:

HPCL4_HUMAN :
  • Q9UM19
Domain:
  • Contains 4 EF-hand domains.
Family:
  • Belongs to the recoverin family.
genes like me logo Genes that share domains with HPCAL4: view

Function for HPCAL4 Gene

Molecular function for HPCAL4 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.

Gene Ontology (GO) - Molecular Function for HPCAL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005246 calcium channel regulator activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0008022 protein C-terminus binding IEA --
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with HPCAL4: view

Phenotypes for HPCAL4 Gene

GenomeRNAi human phenotypes for HPCAL4:
genes like me logo Genes that share phenotypes with HPCAL4: view

Animal Model Products

miRNA for HPCAL4 Gene

miRTarBase miRNAs that target HPCAL4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HPCAL4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HPCAL4 Gene

Localization for HPCAL4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HPCAL4 Gene COMPARTMENTS Subcellular localization image for HPCAL4 gene
Compartment Confidence
cytosol 3
peroxisome 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for HPCAL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
genes like me logo Genes that share ontologies with HPCAL4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HPCAL4 Gene

Pathways for HPCAL4 Gene

SuperPathways for HPCAL4 Gene

genes like me logo Genes that share pathways with HPCAL4: view

Pathways by source for HPCAL4 Gene

1 Qiagen pathway for HPCAL4 Gene

Gene Ontology (GO) - Biological Process for HPCAL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007417 central nervous system development TAS 10520747
genes like me logo Genes that share ontologies with HPCAL4: view

Compounds for HPCAL4 Gene

(1) HMDB Compounds for HPCAL4 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with HPCAL4: view

Transcripts for HPCAL4 Gene

mRNA/cDNA for HPCAL4 Gene

Unigene Clusters for HPCAL4 Gene

Hippocalcin like 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HPCAL4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HPCAL4 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b
SP1: - -
SP2: -
SP3: - - -
SP4: -

Relevant External Links for HPCAL4 Gene

GeneLoc Exon Structure for
HPCAL4
ECgene alternative splicing isoforms for
HPCAL4

Expression for HPCAL4 Gene

mRNA expression in normal human tissues for HPCAL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HPCAL4 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (6.4), Brain - Cortex (6.2), Brain - Amygdala (5.8), Brain - Frontal Cortex (BA9) (5.3), Brain - Nucleus accumbens (basal ganglia) (5.1), Brain - Hippocampus (4.5), Brain - Cerebellum (4.2), and Brain - Cerebellar Hemisphere (4.1).

Protein differential expression in normal tissues for HPCAL4 Gene

This gene is overexpressed in Brain (34.6) and Frontal cortex (11.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HPCAL4 Gene

SOURCE GeneReport for Unigene cluster for HPCAL4 Gene Hs.743975

genes like me logo Genes that share expressions with HPCAL4: view

Expression partners for HPCAL4 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HPCAL4 Gene

Orthologs for HPCAL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for HPCAL4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HPCAL4 35
  • 94.59 (n)
  • 100 (a)
HPCAL4 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HPCAL4 35
  • 95.46 (n)
  • 100 (a)
HPCAL4 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hpcal4 35
  • 93.37 (n)
  • 99.48 (a)
Hpcal4 16
Hpcal4 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HPCAL4 35
  • 100 (n)
  • 100 (a)
HPCAL4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hpcal4 35
  • 92.5 (n)
  • 98.95 (a)
oppossum
(Monodelphis domestica)
Mammalia HPCAL4 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves HPCAL4 35
  • 87.09 (n)
  • 92.15 (a)
HPCAL4 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HPCAL4 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hpcal4 35
  • 78.53 (n)
  • 94.76 (a)
zebrafish
(Danio rerio)
Actinopterygii hpcal4 35
  • 79.41 (n)
  • 90.05 (a)
hpcal4 36
  • 90 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7646 37
  • 43 (a)
Nca 37
  • 71 (a)
Nca 36
  • 71 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ncs-2 37
  • 46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 64 (a)
OneToMany
Species with no ortholog for HPCAL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HPCAL4 Gene

ENSEMBL:
Gene Tree for HPCAL4 (if available)
TreeFam:
Gene Tree for HPCAL4 (if available)

Paralogs for HPCAL4 Gene

Selected SIMAP similar genes for HPCAL4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HPCAL4: view

Variants for HPCAL4 Gene

Sequence variations from dbSNP and Humsavar for HPCAL4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs10839 -- 39,679,146(+) AAAAA(A/T)TATTT utr-variant-3-prime
rs13315 -- 39,680,153(-) AGTTA(C/T)ATTGA utr-variant-3-prime
rs477913 -- 39,687,469(+) GAGCA(C/T)GTCAA intron-variant
rs480318 -- 39,690,563(+) TGGGG(A/C)CTTGG intron-variant
rs482326 -- 39,690,804(+) ACAAC(A/G)AGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HPCAL4 Gene

Variant ID Type Subtype PubMed ID
nsv7177 OTHER Inversion 18451855

Relevant External Links for HPCAL4 Gene

HapMap Linkage Disequilibrium report
HPCAL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HPCAL4 Gene

Disorders for HPCAL4 Gene

Relevant External Links for HPCAL4

Genetic Association Database (GAD)
HPCAL4
Human Genome Epidemiology (HuGE) Navigator
HPCAL4

No disorders were found for HPCAL4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for HPCAL4 Gene

Publications for HPCAL4 Gene

  1. Isolation of two human cDNAs, HLP3 and HLP4, homologous to the neuron-specific calcium-binding protein genes. (PMID: 10520747) Kobayashi M. … Takamatsu K. (DNA Seq. 1998) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4

Products for HPCAL4 Gene

Sources for HPCAL4 Gene

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