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Aliases for HPCAL4 Gene

Aliases for HPCAL4 Gene

  • Hippocalcin Like 4 2 3 5
  • HLP4 3 4

External Ids for HPCAL4 Gene

Previous GeneCards Identifiers for HPCAL4 Gene

  • GC01M040174
  • GC01M039148
  • GC01M039608
  • GC01M039557
  • GC01M039813
  • GC01M039916
  • GC01M038263

Summaries for HPCAL4 Gene

Entrez Gene Summary for HPCAL4 Gene

  • The protein encoded by this gene is highly similar to human hippocalcin protein and hippocalcin like-1 protein. It also has similarity to rat neural visinin-like Ca2+-binding protein-type 1 and 2 proteins. This encoded protein may be involved in the calcium-dependent regulation of rhodopsin phosphorylation. The transcript of this gene has multiple polyadenylation sites. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for HPCAL4 Gene

HPCAL4 (Hippocalcin Like 4) is a Protein Coding gene. Among its related pathways are Visual Cycle in Retinal Rods. GO annotations related to this gene include calcium ion binding and protein C-terminus binding. An important paralog of this gene is KCNIP3.

UniProtKB/Swiss-Prot for HPCAL4 Gene

  • May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.

Gene Wiki entry for HPCAL4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HPCAL4 Gene

Genomics for HPCAL4 Gene

Regulatory Elements for HPCAL4 Gene

Enhancers for HPCAL4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HPCAL4 on UCSC Golden Path with GeneCards custom track

Promoters for HPCAL4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HPCAL4 on UCSC Golden Path with GeneCards custom track

Genomic Location for HPCAL4 Gene

39,678,648 bp from pter
39,691,710 bp from pter
13,063 bases
Minus strand

Genomic View for HPCAL4 Gene

Genes around HPCAL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HPCAL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HPCAL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HPCAL4 Gene

Proteins for HPCAL4 Gene

  • Protein details for HPCAL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hippocalcin-like protein 4
    Protein Accession:
    Secondary Accessions:
    • B2R5U2
    • D3DPU1
    • Q5TG97
    • Q8N611

    Protein attributes for HPCAL4 Gene

    191 amino acids
    Molecular mass:
    22202 Da
    Quaternary structure:
    No Data Available
    • Probably binds two or three calcium ions.

neXtProt entry for HPCAL4 Gene

Proteomics data for HPCAL4 Gene at MOPED

Post-translational modifications for HPCAL4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HPCAL4 Gene

No data available for DME Specific Peptides for HPCAL4 Gene

Domains & Families for HPCAL4 Gene

Gene Families for HPCAL4 Gene

Protein Domains for HPCAL4 Gene

Suggested Antigen Peptide Sequences for HPCAL4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 EF-hand domains.
  • Belongs to the recoverin family.
  • Contains 4 EF-hand domains.
  • Belongs to the recoverin family.
genes like me logo Genes that share domains with HPCAL4: view

Function for HPCAL4 Gene

Molecular function for HPCAL4 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.

Gene Ontology (GO) - Molecular Function for HPCAL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005246 calcium channel regulator activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008022 protein C-terminus binding IEA --
genes like me logo Genes that share ontologies with HPCAL4: view

Phenotypes for HPCAL4 Gene

genes like me logo Genes that share phenotypes with HPCAL4: view

Animal Models for HPCAL4 Gene

MGI Knock Outs for HPCAL4:

Animal Model Products

miRNA for HPCAL4 Gene

miRTarBase miRNAs that target HPCAL4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HPCAL4 Gene

Localization for HPCAL4 Gene

Subcellular locations from

Jensen Localization Image for HPCAL4 Gene COMPARTMENTS Subcellular localization image for HPCAL4 gene
Compartment Confidence
cytosol 3
peroxisome 2
extracellular 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for HPCAL4 Gene

Pathways & Interactions for HPCAL4 Gene

SuperPathways for HPCAL4 Gene

genes like me logo Genes that share pathways with HPCAL4: view

Pathways by source for HPCAL4 Gene

1 Qiagen pathway for HPCAL4 Gene

Gene Ontology (GO) - Biological Process for HPCAL4 Gene


No data available for SIGNOR curated interactions for HPCAL4 Gene

Drugs & Compounds for HPCAL4 Gene

(1) Drugs for HPCAL4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with HPCAL4: view

Transcripts for HPCAL4 Gene

Unigene Clusters for HPCAL4 Gene

Hippocalcin like 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HPCAL4 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b
SP1: - -
SP2: -
SP3: - - -
SP4: -

Relevant External Links for HPCAL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HPCAL4 Gene

mRNA expression in normal human tissues for HPCAL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HPCAL4 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x6.4), Brain - Cortex (x6.2), Brain - Amygdala (x5.8), Brain - Frontal Cortex (BA9) (x5.3), Brain - Nucleus accumbens (basal ganglia) (x5.1), Brain - Hippocampus (x4.5), Brain - Cerebellum (x4.2), and Brain - Cerebellar Hemisphere (x4.1).

Protein differential expression in normal tissues from HIPED for HPCAL4 Gene

This gene is overexpressed in Brain (34.6) and Frontal cortex (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HPCAL4 Gene

SOURCE GeneReport for Unigene cluster for HPCAL4 Gene Hs.743975

genes like me logo Genes that share expression patterns with HPCAL4: view

Protein tissue co-expression partners for HPCAL4 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for HPCAL4 Gene

Orthologs for HPCAL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for HPCAL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HPCAL4 35
  • 94.59 (n)
  • 100 (a)
  • 100 (a)
(Canis familiaris)
Mammalia HPCAL4 35
  • 95.46 (n)
  • 100 (a)
  • 100 (a)
(Mus musculus)
Mammalia Hpcal4 35
  • 93.37 (n)
  • 99.48 (a)
Hpcal4 16
Hpcal4 36
  • 99 (a)
(Pan troglodytes)
Mammalia HPCAL4 35
  • 100 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Hpcal4 35
  • 92.5 (n)
  • 98.95 (a)
(Monodelphis domestica)
Mammalia HPCAL4 36
  • 89 (a)
(Gallus gallus)
Aves HPCAL4 35
  • 87.09 (n)
  • 92.15 (a)
  • 92 (a)
(Anolis carolinensis)
Reptilia HPCAL4 36
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hpcal4 35
  • 78.53 (n)
  • 94.76 (a)
(Danio rerio)
Actinopterygii hpcal4 35
  • 79.41 (n)
  • 90.05 (a)
hpcal4 36
  • 90 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7646 37
  • 43 (a)
Nca 37
  • 71 (a)
Nca 36
  • 71 (a)
(Caenorhabditis elegans)
Secernentea ncs-2 37
  • 46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 64 (a)
Species with no ortholog for HPCAL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HPCAL4 Gene

Gene Tree for HPCAL4 (if available)
Gene Tree for HPCAL4 (if available)

Paralogs for HPCAL4 Gene

(18) SIMAP similar genes for HPCAL4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HPCAL4: view

Variants for HPCAL4 Gene

Sequence variations from dbSNP and Humsavar for HPCAL4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10839 -- 39,679,146(+) AAAAA(A/T)TATTT utr-variant-3-prime
rs13315 -- 39,680,153(-) AGTTA(C/T)ATTGA utr-variant-3-prime
rs477913 -- 39,687,469(+) GAGCA(C/T)GTCAA intron-variant
rs480318 -- 39,690,563(+) TGGGG(A/C)CTTGG intron-variant
rs482326 -- 39,690,804(+) ACAAC(A/G)AGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HPCAL4 Gene

Variant ID Type Subtype PubMed ID
nsv7177 OTHER Inversion 18451855

Variation tolerance for HPCAL4 Gene

Residual Variation Intolerance Score: 36.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.35% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HPCAL4 Gene

Disorders for HPCAL4 Gene

Relevant External Links for HPCAL4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HPCAL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HPCAL4 Gene

Publications for HPCAL4 Gene

  1. Isolation of two human cDNAs, HLP3 and HLP4, homologous to the neuron-specific calcium-binding protein genes. (PMID: 10520747) Kobayashi M. … Takamatsu K. (DNA Seq. 1998) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. The EHEC-host interactome reveals novel targets for the translocated intimin receptor. (PMID: 25519916) Blasche S. … Koegl M. (Sci Rep 2014) 3
  5. Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover. (PMID: 24035498) Tan M.K. … Harper J.W. (Mol. Cell 2013) 3

Products for HPCAL4 Gene

Sources for HPCAL4 Gene