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HPCAL4 Gene

protein-coding   GIFtS: 52
GCID: GC01M040174

Hippocalcin Like 4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hippocalcin Like 41 2
HLP42 3
Hippocalcin-Like Protein 42

External Ids:    HGNC: 182121   Entrez Gene: 514402   Ensembl: ENSG000001169837   UniProtKB: Q9UM193   

Export aliases for HPCAL4 gene to outside databases

Previous GC identifers: GC01M039148 GC01M039608 GC01M039557 GC01M039813 GC01M039916 GC01M038263


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HPCAL4 Gene:
The protein encoded by this gene is highly similar to human hippocalcin protein and hippocalcin like-1 protein. It
also has similarity to rat neural visinin-like Ca2+-binding protein-type 1 and 2 proteins. This encoded protein
may be involved in the calcium-dependent regulation of rhodopsin phosphorylation. The transcript of this gene has
multiple polyadenylation sites. Alternatively spliced transcript variants encoding different isoforms have been
found for this gene. (provided by RefSeq, Sep 2013)

GeneCards Summary for HPCAL4 Gene:
HPCAL4 (hippocalcin like 4) is a protein-coding gene. GO annotations related to this gene include protein domain specific binding and calcium ion binding. An important paralog of this gene is HPCA.

UniProtKB/Swiss-Prot: HPCL4_HUMAN, Q9UM19
Function: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation (By similarity)

Gene Wiki entry for HPCAL4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the HPCAL4 gene promoter:
         Oct-B1   POU2F2C   Max1   POU2F1   oct-B3   oct-B2   Sp1   POU2F1a   POU2F2B   POU2F2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHPCAL4 promoter sequence
   Search Chromatin IP Primers for HPCAL4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HPCAL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.2   Ensembl cytogenetic band:  1p34.2   HGNC cytogenetic band: 1p34.2

HPCAL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HPCAL4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M040174:  view genomic region     (about GC identifiers)

Start:
40,144,320 bp from pter      End:
40,157,361 bp from pter
Size:
13,042 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HPCL4_HUMAN, Q9UM19 (See protein sequence)
Recommended Name: Hippocalcin-like protein 4  
Size: 191 amino acids; 22202 Da
Miscellaneous: Probably binds two or three calcium ions (By similarity)
Secondary accessions: B2R5U2 D3DPU1 Q5TG97 Q8N611

Explore the universe of human proteins at neXtProt for HPCAL4: NX_Q9UM19

Explore proteomics data for HPCAL4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HPCAL4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001269325.1  NP_001269326.1  NP_057341.1  

    ENSEMBL proteins: 
     ENSP00000361935  

    HPCAL4 Human Recombinant Protein Products:

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    Novus Biologicals HPCAL4 Protein
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    Cloud-Clone Corp. Proteins for HPCAL4

     
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    Cloud-Clone Corp. ELISAs for HPCAL4
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    Search eBioscience for ELISAs for HPCAL4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    4 InterPro protein domains:
     IPR001125 Recoverin_like
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry Q9UM19

    ProtoNet protein and cluster: Q9UM19

    1 Blocks protein domain: IPB001125 Recoverin family signature

    UniProtKB/Swiss-Prot: HPCL4_HUMAN, Q9UM19
    Similarity: Belongs to the recoverin family
    Similarity: Contains 4 EF-hand domains


    Find genes that share domains with HPCAL4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HPCL4_HUMAN, Q9UM19
    Function: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005246calcium channel regulator activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0008022protein C-terminus binding IEA--
    GO:0019904protein domain specific binding IEA--
         
    Find genes that share ontologies with HPCAL4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for HPCAL4:
     Increased gamma-H2AX phosphory 

         1 MGI phenotypic allele for Hpcal4 (no phenotypes)

    Find genes that share phenotypes with HPCAL4           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HPCAL4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HPCAL4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HPCAL4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HPCAL4

    miRNA
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    miRTarBase miRNAs that target HPCAL4:
    hsa-mir-744-5p (MIRT037510)

    Block miRNA regulation of human, mouse, rat HPCAL4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HPCAL4 (see all 62):
    hsa-miR-124* hsa-miR-328 hsa-miR-3194-5p hsa-miR-15a hsa-miR-218-1* hsa-miR-29a hsa-miR-3916 hsa-miR-1304
    SwitchGear 3'UTR luciferase reporter plasmidHPCAL4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HPCAL4
    Predesigned siRNA for gene silencing in human, mouse, rat HPCAL4

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: HPCAL4 (NM_016257)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HPCAL4

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HPCAL4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    peroxisome2
    extracellular1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--

    Find genes that share ontologies with HPCAL4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HPCAL4 About    
    See pathways by source

    SuperPathContained pathways About
    1Visual Cycle in Retinal Rods
    Visual Cycle in Retinal Rods

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for HPCAL4
        Visual Cycle in Retinal Rods


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HPCAL4
    Interactions:

        Search GeneGlobe Interaction Network for HPCAL4

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for HPCAL4 (Q9UM192, 3 ENSP000003619354) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE3AQ050862, 3, ENSP000003810454MINT-8276428 I2D: score=2 STRING: ENSP00000381045
    DTX2Q86UW92, 3, ENSP000003228854MINT-66565 I2D: score=4 STRING: ENSP00000322885
    TSC22D3Q995763, ENSP000003614584I2D: score=4 STRING: ENSP00000361458
    HOXA1P496393I2D: score=1 
    NECAB2Q7Z6G33I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007417central nervous system development TAS10520747

    Find genes that share ontologies with HPCAL4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HPCAL4 (HPCL4)

    1 HMDB Compound for HPCAL4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HPCAL4 gene (3 alternative transcripts): 
    NM_001282396.1  NM_001282397.1  NM_016257.3  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000372844(uc001cdr.3 uc010oix.2)
    miRNA
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    Block miRNA regulation of human, mouse, rat HPCAL4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HPCAL4 (see all 62):
    hsa-miR-124* hsa-miR-328 hsa-miR-3194-5p hsa-miR-15a hsa-miR-218-1* hsa-miR-29a hsa-miR-3916 hsa-miR-1304
    SwitchGear 3'UTR luciferase reporter plasmidHPCAL4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HPCAL4
    Predesigned siRNA for gene silencing in human, mouse, rat HPCAL4
    Clone
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    OriGene clones in human, mouse for HPCAL4 (see all 7)
    OriGene ORF clones in mouse, rat for HPCAL4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HPCAL4 (NM_016257)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HPCAL4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HPCAL4
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for HPCAL4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HPCAL4
      QuantiTect SYBR Green Assays in human, mouse, rat HPCAL4
      QuantiFast Probe-based Assays in human, mouse, rat HPCAL4

    Selected AceView cDNA sequences (see all 81):

    AI937392 BM699329 NM_016257 AA776934 AA704044 BM703016 N49163 T05937 
    AA621040 AI654703 BE550384 F02040 BP350259 BM669991 AI968033 BI670280 
    BP347958 BX478459 R46393 BU729243 F10174 T03619 BF221491 CB155770 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for HPCAL4    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b
    SP1:              -           -                                 
    SP2:                          -                                 
    SP3:              -           -     -                           
    SP4:              -                                             


    ECgene alternative splicing isoforms for HPCAL4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HPCAL4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTATTCAT
    HPCAL4 Expression
    About this image


    HPCAL4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Amygdala
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot
     
     Blood (Hematopoietic System)
             T Helper Cells Peripheral Blood
    HPCAL4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HPCAL4 Protein Expression
        Custom PCR Arrays for HPCAL4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HPCAL4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HPCAL4 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hpcal41 , 5 hippocalcin-like 41, 5 93.37(n)1
    99.48(a)1
      4 (57.40 cM)5
    1706381  NM_174998.41  NP_778163.11 
     1231832275 
    chicken
    (Gallus gallus)
    Aves HPCAL41 hippocalcin like 4 87.09(n)
    92.15(a)
      419676  XM_417823.4  XP_417823.3 
    lizard
    (Anolis carolinensis)
    Reptilia HPCAL46
    hippocalcin like 4
    94(a)
    1 ↔ 1
    GL343481.1(188614-194010)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia hpcal41 hippocalcin like 4 78.53(n)
    94.76(a)
      780259  NM_001079330.1  NP_001072798.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hpcal41 hippocalcin like 4 79.41(n)
    90.05(a)
      564909  NM_001114687.1  NP_001108159.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nca3 negative regulation of phosphorylation
    calcium more
    71(a)
    (best of 2)
      3 76D8   --


    ENSEMBL Gene Tree for HPCAL4 (if available)
    TreeFam Gene Tree for HPCAL4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HPCAL4 gene
    HPCA2  KCNIP32  KCNIP42  KCNIP12  GUCA1A2  RCVRN2  HPCAL12  GUCA1B2  
    NCALD2  KCNIP22  NCS12  GUCA1C2  VSNL12  
    18 SIMAP similar genes for HPCAL4 using alignment to 1 protein entry:     HPCL4_HUMAN:
    VSNL1    NCALD    DKFZp781K1922    HPCAL1    HPCA    NCS1
    KCNIP4    RCVRN    GUCA1B    KCNIP1    KCNIP3    DKFZp686E1183
    GUCA1A    KCNIP2    GUCA1C    HZGJ    PPP3R2    PPP3R1

    Find genes that share paralogs with HPCAL4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HPCAL4 (see all 316)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1131710001,2
    C--40151552(+) ACCTC-/A/AAA 
            
    AAAAA
    2 -- int1 cds11CSA 2
    rs104658331,2
    C,F,H--40221668(+) GTAGGC/GAAGAG 1 -- ds500114Minor allele frequency- N:0.00EA NA NS WA 998
    rs772634441,2
    C--40221800(+) GGAGGA/GGATAG 1 -- ds50010--------
    rs10621031,2
    C,F,O,A--40221853(-) GGAAGG/TGGGGG 1 -- ds50019Minor allele frequency- T:0.50EA MN NA WA CSA 2040
    rs22813021,2
    C--40221903(+) CTGACC/TGGCCT 1 -- ds5001 ese30--------
    rs742256831,2
    --40221956(+) TGCCCC/TCACAC 1 -- ds50010--------
    rs108391,2
    C,F,O,A,H--40222185(+) AAAAAA/TTATTT 1 -- ut3130Minor allele frequency- N:0.00MN EA NA NS WA CSA 4274
    rs1116335341,2
    C--40222224(+) CCCAG-/CTT   
       CTTCT
    CTTCT
    1 -- ut311Minor allele frequency- CTTCTTCT:0.50CSA 2
    rs38308211,2
    C--40222235(+) CTCTT-/CTTCTCT
    T
    /TCTTCTCT
    TCTTT
    2 -- ut31 trp30--------
    rs1997614881,2
    C--40222247(-) ATGGGA/GGNNNN 1 -- ut310--------

    HapMap Linkage Disequilibrium report for HPCAL4 (40144320 - 40157361 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HPCAL4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7177OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HPCAL4
    DNA2.0 Custom Variant and Variant Library Synthesis for HPCAL4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with HPCAL4           About GenesLikeMe

    Genetic Association Database (GAD): HPCAL4
    Human Genome Epidemiology (HuGE) Navigator: HPCAL4 (1 document)

    Export disorders for HPCAL4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HPCAL4 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with HPCAL4)
        Utopia: connect your pdf to the dynamic
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    1. Isolation of two human cDNAs, HLP3 and HLP4, homologous to the neuron-specific calcium-binding protein genes. (PubMed id 10520747)1, 2, 3, 9 Kobayashi M.... Takamatsu K. (DNA Seq. 1998)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    6. Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover. (PubMed id 24035498)1 Tan M.K....Harper J.W. (Mol. Cell 2013)
    7. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (Nucleic Acids Res. 2006)
    10. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51440 HGNC: 18212 AceView: HPCAL4 Ensembl:ENSG00000116983 euGenes: HUgn51440
    ECgene: HPCAL4 H-InvDB: HPCAL4

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HPCAL4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HPCAL4 gene:
    Search GeneIP for patents involving HPCAL4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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