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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HPCAL1 Gene

protein-coding   GIFtS: 60
GCID: GC02P010443

Hippocalcin-Like 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Hippocalcin-Like 11 2     HLP22 3
Calcium-Binding Protein BDR-11 2 3     VILIP-32 3
Visinin-Like Protein 31 2 3     Hippocalcin-Like Protein 12
BDR12 3     

External Ids:    HGNC: 51451   Entrez Gene: 32412   Ensembl: ENSG000001157567   OMIM: 6002075   UniProtKB: P372353   

Export aliases for HPCAL1 gene to outside databases

Previous GC identifers: GC02P010228 GC02P010494 GC02P010464 GC02P010393


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HPCAL1 Gene:
The protein encoded by this gene is a member of neuron-specific calcium-binding proteins family found in the
retina and brain. It is highly similar to human hippocalcin protein and nearly identical to the rat and mouse
hippocalcin like-1 proteins. It may be involved in the calcium-dependent regulation of rhodopsin phosphorylation
and may be of relevance for neuronal signalling in the central nervous system. Several alternatively spliced
transcript variants encoding the same protein have been found for this gene. (provided by RefSeq, Apr 2012)

GeneCards Summary for HPCAL1 Gene: 
HPCAL1 (hippocalcin-like 1) is a protein-coding gene. Diseases associated with HPCAL1 include neuronitis, and hypertension. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is HPCA.

UniProtKB/Swiss-Prot: HPCL1_HUMAN, P37235
Function: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation

Gene Wiki entry for HPCAL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005334.16  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HPCAL1 gene promoter:
         AP-2beta   HNF-4alpha2   Meis-1a   HNF-4alpha1   Meis-1   Meis-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHPCAL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for HPCAL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HPCAL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25.1   Ensembl cytogenetic band:  2p25.1   HGNC cytogenetic band: 2p25.1

HPCAL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HPCAL1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P010443:  view genomic region     (about GC identifiers)

Start:
10,443,015 bp from pter      End:
10,567,743 bp from pter
Size:
124,729 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HPCL1_HUMAN, P37235 (See protein sequence)
Recommended Name: Hippocalcin-like protein 1  
Size: 193 amino acids; 22313 Da
Miscellaneous: Probably binds two or three calcium ions (By similarity)
Secondary accessions: Q969S5

Explore the universe of human proteins at neXtProt for HPCAL1: NX_P37235

Explore proteomics data for HPCAL1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P37235

  • HPCAL1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HPCAL1 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001245286.1  NP_001245287.1  NP_001245288.1  NP_002140.2  NP_602293.1  

    ENSEMBL proteins: 
     ENSP00000413689   ENSP00000310749   ENSP00000371184   ENSP00000416359   ENSP00000388856  

    Human Recombinant Protein Products for HPCAL1: 
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    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for HPCAL1
    Cloud-Clone Corp. Proteins for HPCAL1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix ----

    HPCAL1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    EFHAND: EF-hand domain containing

    4 InterPro protein domains:
     IPR001125 Recoverin
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry P37235

    ProtoNet protein and cluster: P37235

    1 Blocks protein domain: IPB001125 Recoverin family signature

    UniProtKB/Swiss-Prot: HPCL1_HUMAN, P37235
    Similarity: Belongs to the recoverin family
    Similarity: Contains 4 EF-hand domains


    HPCAL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HPCL1_HUMAN, P37235
    Function: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation

         Genatlas biochemistry entry for HPCAL1:
    calcium binding protein,hippocalcin-like,expressed in brain

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    HPCAL1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Hpcal1 (no phenotypes)

    HPCAL1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HPCAL1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HPCAL1 
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    SwitchGear 3'UTR luciferase reporter plasmidHPCAL1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HPCAL1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Visual Cycle in Retinal Rods
    Visual Cycle in Retinal Rods

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for HPCAL1
        Visual Cycle in Retinal Rods


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HPCAL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/18 Interacting proteins for HPCAL1 (P372352, 3 ENSP000003107494) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HMG20AQ9NP662, 3, ENSP000003368564MINT-68016 I2D: score=5 STRING: ENSP00000336856
    DTX2Q86UW92, 3, ENSP000003228854MINT-67483 I2D: score=4 STRING: ENSP00000322885
    ATXN1P542533, ENSP000002447694I2D: score=2 STRING: ENSP00000244769
    SLC34A1Q064953, ENSP000003214244I2D: score=1 STRING: ENSP00000321424
    IKBKGQ9Y6K93, ENSP000003586224I2D: score=1 STRING: ENSP00000358622
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----

    HPCAL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HPCAL1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HPCAL1 (HPCL1)

    1 HMDB Compound for HPCAL1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 Novoseek inferred chemical compound relationship for HPCAL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 23.2 6 10683417 (2), 12614903 (1), 18989702 (1)

    Search CenterWatch for drugs/clinical trials and news about HPCAL1 / HPCL1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HPCAL1 gene (5 alternative transcripts): 
    NM_001258357.1  NM_001258358.1  NM_001258359.1  NM_002149.3  NM_134421.2  

    Unigene Cluster for HPCAL1:

    Hippocalcin-like 1
    Hs.580427  [show with all ESTs]
    Unigene Representative Sequence: CR749837
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000423674 ENST00000307845(uc002raj.3) ENST00000381765(uc002ral.3 uc010exf.3)
    ENST00000419810(uc010exe.3) ENST00000422133

    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate HPCAL1:
    hsa-miR-374c hsa-miR-655 hsa-miR-198 hsa-miR-586 hsa-miR-32* hsa-miR-412
    SwitchGear 3'UTR luciferase reporter plasmidHPCAL1 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HPCAL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HPCAL1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HPCAL1
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    Additional mRNA sequence: 

    AF070616.1 AK000596.1 AK093973.1 AK126732.1 AK292280.1 BC009846.2 BC017028.1 BC017482.1 
    BT009835.1 CR541975.1 CR749837.1 D16227.1 

    13 DOTS entries:

    DT.85105581  DT.100797295  DT.100043084  DT.95083302  DT.101972123  DT.99956155  DT.95138632  DT.100043042 
    DT.100720747  DT.91775828  DT.97861204  DT.102830058  DT.91775820 

    24/315 AceView cDNA sequences (see all 315):

    CR607303 AV728984 AA346219 D11978 BU789070 BC017482 BQ649273 CR599915 
    BU859245 BU180151 CK820260 CA419164 BU789332 AA970853 AA991312 AA902426 
    CR591594 CR605568 BQ000020 BU732101 BQ574930 BG481893 BQ649810 CB122517 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for HPCAL1 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d
    SP1:                    -     -     -     -     -           -     -                             -                           
    SP2:              -     -     -     -     -     -           -     -                             -                           
    SP3:                                      -     -           -     -                             -                           
    SP4:                                                                                                                        
    SP5:              -     -     -     -     -     -                                                                           


    ECgene alternative splicing isoforms for HPCAL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HPCAL1 expression in normal human tissues (normalized intensities)      HPCAL1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGCCCTGA
    HPCAL1 Expression
    About this image


    HPCAL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 15 entries
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Cholinergic Amacrine Cells Inner Nuclear Layer
     
     Uterus (Reproductive System)
             CERVIX   
     
     Uncategorized (Uncategorized)
             PureStem Progenitor E44

    See HPCAL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HPCAL1

    SOURCE GeneReport for Unigene cluster: Hs.580427
        SABiosciences Custom PCR Arrays for HPCAL1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HPCAL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HPCAL1 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hpcal11 , 5 hippocalcin-like 11, 5 92.06(n)1
    98.45(a)1
      12 (8.13 cM)5
    536021  NM_016677.41  NP_057886.11 
     176908145 
    chicken
    (Gallus gallus)
    Aves HPCAL11 hippocalcin-like 1 87.74(n)
    98.45(a)
      396161  NM_205234.1  NP_990565.1 
    lizard
    (Anolis carolinensis)
    Reptilia HPCA6
    Uncharacterized protein
    99(a)
    possible ortholog
    1(147593421-147706274)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc731262 hypothetical protein MGC73126 84.8(n)   393696  BC059489.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nca1 , 3 negative regulation of phosphorylation
    calcium more3
    Neurocalcin1
    89(a)
    (best of 4)3
    70.37(n)1
    89.42(a)1
      3 76D83
    401861  NM_001170007.11  NP_001163478.11 


    ENSEMBL Gene Tree for HPCAL1 (if available)
    TreeFam Gene Tree for HPCAL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HPCAL1 gene
    HPCA2  KCNIP32  KCNIP42  KCNIP12  GUCA1A2  RCVRN2  GUCA1B2  NCALD2  
    KCNIP22  HPCAL42  NCS12  GUCA1C2  VSNL12  
    18/22 SIMAP similar genes for HPCAL1 using alignment to 5 protein entries:     HPCL1_HUMAN (see all proteins) (see all similar genes):
    DKFZp781K1922    NCALD    HPCA    VSNL1    HPCAL4    NCS1
    RCVRN    KCNIP4    KCNIP3    GUCA1A    KCNIP2    KCNIP1
    GUCA1B    DKFZp686E1183    EFCAB1    GUCA1C    PPP3R2    PPP3R1

    HPCAL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2880 SNPs in HPCAL1 are shown (see all 2880)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1892216051,2
    C--10441094(+) GGGACG/TCAAGG 1 -- us2k10--------
    rs3753571801,2
    C--10441133(+) AGAGAC/TACACT 1 -- us2k10--------
    rs1926599901,2
    --10441195(+) AGAGGA/TAGCAT 1 -- us2k10--------
    rs739140371,2
    C--10441419(+) CTCCTG/ACCTGT 1 -- us2k12Minor allele frequency- A:0.07WA 120
    rs1847926701,2
    --10441465(+) ACAGAC/TTTTGC 1 -- us2k10--------
    rs1893077621,2
    --10441565(+) TCCGAA/GACACT 1 -- us2k10--------
    rs1400074911,2
    --10441623(+) GCGACA/TACTTC 1 -- us2k10--------
    rs1498654151,2
    --10441636(+) GCCCAC/TGGATG 1 -- us2k10--------
    rs1438766491,2
    --10441731(+) CCTGGA/GTACTT 1 -- us2k10--------
    rs727716631,2
    C,F--10441790(+) GGGTAC/TCGGGC 1 -- us2k11Minor allele frequency- T:0.07NA 120

    HapMap Linkage Disequilibrium report for HPCAL1 (10443015 - 10567743 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for HPCAL1 (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv679e199CNV Deletion23128226
    esv2719644CNV Deletion23290073
    esv2719646CNV Deletion23290073
    dgv628e201CNV Deletion23290073
    esv2719650CNV Deletion23290073
    esv2719648CNV Deletion23290073
    esv1007136CNV Insertion20482838
    nsv508827CNV Insertion20534489
    nsv2605CNV Insertion18451855
    nsv873639CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600207    OMIM disorders: --

    5 diseases for HPCAL1:    About MalaCards
    neuronitis    hypertension    retinitis    alzheimer's disease
    breast cancer


    HPCAL1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): HPCAL1
    Human Genome Epidemiology (HuGE) Navigator: HPCAL1 (2 documents)

    Export disorders for HPCAL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HPCAL1 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with HPCAL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel calcium-binding protein structurally related to hippocalcin from human brain and chromosomal mapping of its gene. (PubMed id 8038222)1, 2, 3 Kobayashi M.... Noguchi T. (1994)
    2. Hypertension susceptibility genes on chromosome 2p24-p25 in a general Japanese population. (PubMed id 15834280)1, 4, 9 Kamide K....Miyata T. (2005)
    3. Neuronal calcium sensor protein visinin-like protein-3 interacts with microsomal cytochrome b5 in a Ca2+-dependent manner. (PubMed id 14739275)1, 3 Oikawa K....Tateno M. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The neuronal EF-hand calcium-binding protein visinin-like protein-3 is expressed in cerebellar Purkinje cells and shows a calcium-dependent membrane association. (PubMed id 10683417)1, 9 Spilker C....Braunewell K.H. (2000)
    6. Regional and cellular distribution of neural visinin-like protein immunoreactivities (VILIP-1 and VILIP-3) in human brain. (PubMed id 10851344)1, 9 Bernstein H.G....Braunewell K.H. (1999)
    7. Functional contribution of Ca2+ and Mg2+ to the intermolecular interaction of visinin-like proteins. (PubMed id 16703469)1, 9 Jheng F.F....Chang L.S. (2006)
    8. Abnormal localization of two neuronal calcium sensor proteins, visinin-like proteins (vilips)-1 and -3, in neocortical brain areas of Alzheimer disease patients. (PubMed id 11173883)1, 9 Braunewell K....Bernstein H.G. (2001)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3241 HGNC: 5145 AceView: HPCAL1 Ensembl:ENSG00000115756 euGenes: HUgn3241
    ECgene: HPCAL1 H-InvDB: HPCAL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HPCAL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HPCAL1 gene:
    Search GeneIP for patents involving HPCAL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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