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HPCA Gene

protein-coding   GIFtS: 58
GCID: GC01P033351

Hippocalcin

  See HPCA-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
hippocalcin1 2
Calcium-Binding Protein BDR-22 3
BDR22 3
Neuron Specific Calcium-Binding Protein Hippocalcin2
Neuron-Specific Calcium-Binding Protein Hippocalcin2

External Ids:    HGNC: 51441   Entrez Gene: 32082   Ensembl: ENSG000001219057   OMIM: 1426225   UniProtKB: P840743   

Export aliases for HPCA gene to outside databases

Previous GC identifers: GC01P033171 GC01P032307 GC01P032778 GC01P032854 GC01P033021 GC01P033124 GC01P031469


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HPCA Gene:
The protein encoded by this gene is a member of neuron-specific calcium-binding proteins family found in the
retina and brain. This protein is associated with the plasma membrane. It has similarities to proteins located in
the photoreceptor cells that regulate photosignal transduction in a calcium-sensitive manner. This protein
displays recoverin activity and a calcium-dependent inhibition of rhodopsin kinase. It is identical to the rat
and mouse hippocalcin proteins and thought to play an important role in neurons of the central nervous system in
a number of species. (provided by RefSeq, Jul 2008)

GeneCards Summary for HPCA Gene:
HPCA (hippocalcin) is a protein-coding gene. Diseases associated with HPCA include ascending cholangitis. GO annotations related to this gene include actin binding and calcium ion binding. An important paralog of this gene is KCNIP3.

UniProtKB/Swiss-Prot: HPCA_HUMAN, P84074
Function: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds two calcium ions

Gene Wiki entry for HPCA (Hippocalcin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HPCA gene promoter:
         Nkx3-1   CREB   deltaCREB   NRSF form 1   Nkx3-1 v3   NRSF form 2   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHPCA promoter sequence
   Search Chromatin IP Primers for HPCA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HPCA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35-p34.2   Ensembl cytogenetic band:  1p35.1   HGNC cytogenetic band: 1p35-p34.2

HPCA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HPCA gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P033351:  view genomic region     (about GC identifiers)

Start:
33,351,595 bp from pter      End:
33,364,042 bp from pter
Size:
12,448 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HPCA_HUMAN, P84074 (See protein sequence)
Recommended Name: Neuron-specific calcium-binding protein hippocalcin  
Size: 193 amino acids; 22427 Da
Secondary accessions: B2R9T3 D3DPQ7 P32076 P41211 P70510

Explore the universe of human proteins at neXtProt for HPCA: NX_P84074

Explore proteomics data for HPCA at MOPED

Post-translational modifications: 

  • Myristoylation facilitates interaction with membranes (By similarity)1
  • Ubiquitination2 at Lys63, Lys174
  • Modification sites at PhosphoSitePlus

  • See HPCA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002134.2  
    ENSEMBL proteins: 
     ENSP00000362566  

    HPCA Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for HPCA

     
    Search eBioscience for Proteins for HPCA 

     
    antibodies-online proteins for HPCA (6 products) 

     
    antibodies-online peptides for HPCA

    HPCA Antibody Products:

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    antibodies-online antibodies for HPCA (27 products) 

    HPCA Assay Products:

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    Cloud-Clone Corp. ELISAs for HPCA
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    Search eBioscience for ELISAs for HPCA 
    antibodies-online kits for HPCA (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    4 InterPro protein domains:
     IPR001125 Recoverin_like
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry P84074

    ProtoNet protein and cluster: P84074

    1 Blocks protein domain: IPB001125 Recoverin family signature

    UniProtKB/Swiss-Prot: HPCA_HUMAN, P84074
    Similarity: Belongs to the recoverin family
    Similarity: Contains 4 EF-hand domains


    Find genes that share domains with HPCA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HPCA_HUMAN, P84074
    Function: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds two calcium ions

         Genatlas biochemistry entry for HPCA:
    hippocalcin,23kDa,calcium binding protein expressed in hippocampus

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IDA11964161
    GO:0005509calcium ion binding NAS8387172
    GO:0005515protein binding ----
         
    Find genes that share ontologies with HPCA           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hpca):
     cellular  homeostasis/metabolism  nervous system 

    Find genes that share phenotypes with HPCA           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Hpcatm1Toho for HPCA

       genOway: Develop your customized and physiologically relevant rodent model for HPCA

    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate HPCA:
    hsa-miR-4283 hsa-miR-361-3p hsa-miR-1321 hsa-miR-3133
    SwitchGear 3'UTR luciferase reporter plasmidHPCA 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat HPCA

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HPCA

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HPCA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including HPCA: 
              Huntington's Disease in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HPCA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for HPCA (P840743 ENSP000003625664) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NMT1P304193, ENSP000002589604I2D: score=1 STRING: ENSP00000258960
    MAP3K10Q027793, ENSP000002530554I2D: score=1 STRING: ENSP00000253055
    NAIPQ130753I2D: score=2 
    AP2B1P630103I2D: score=1 
    KCNMA1Q127913I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0048839inner ear development IEA--

    Find genes that share ontologies with HPCA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HPCA

    1 HMDB Compound for HPCA    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 Novoseek inferred chemical compound relationship for HPCA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 42.9 21 10899114 (4), 14638856 (3), 19686238 (2), 9872924 (1) (see all 12)



    Find genes that share compounds with HPCA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HPCA gene: 
    NM_002143.2  

    Unigene Cluster for HPCA:

    Hippocalcin
    Hs.632391  [show with all ESTs]
    Unigene Representative Sequence: NM_002143
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000470166 ENST00000480118 ENST00000373467(uc001bwh.3) ENST00000459874
    ENST00000470896
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate HPCA:
    hsa-miR-4283 hsa-miR-361-3p hsa-miR-1321 hsa-miR-3133
    SwitchGear 3'UTR luciferase reporter plasmidHPCA 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for HPCA
    Predesigned siRNA for gene silencing in human, mouse, rat HPCA
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    GenScript: all cDNA clones in your preferred vector: HPCA (NM_002143)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HPCA
    Primer
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    OriGene qPCR primer pairs and template standards for HPCA
    OriGene qSTAR qPCR primer pairs in human, mouse for HPCA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HPCA
      QuantiTect SYBR Green Assays in human, mouse, rat HPCA
      QuantiFast Probe-based Assays in human, mouse, rat HPCA

    Additional mRNA sequence: 

    AK313907.1 BC001777.1 BT019750.1 BT019789.1 D16593.1 

    6 DOTS entries:

    DT.40268615  DT.211888  DT.95333184  DT.75138179  DT.97817634  DT.97838250 

    Selected AceView cDNA sequences (see all 101):

    AI968637 AI936796 AW593961 BF056926 F08502 BQ187927 BU730131 BU193377 
    BC001777 AI633788 BE254310 AI815633 BM695772 NM_002143 AI018743 AI572446 
    BM703729 BM470677 BM727278 BG699790 BG699600 BI669510 BE504818 BQ185637 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for HPCA    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c
    SP1:                                                      
    SP2:              -     -     -                           
    SP3:              -     -                                 
    SP4:                          -                           


    ECgene alternative splicing isoforms for HPCA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HPCA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGCCAAATG
    HPCA Expression
    About this image


    HPCA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Cerebral Cortex
             Caudate nucleus   
     
     Eye (Sensory Organs)
    HPCA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HPCA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632391

    UniProtKB/Swiss-Prot: HPCA_HUMAN, P84074
    Tissue specificity: Brain specific

        Pathway & Disease-focused RT2 Profiler PCR Array including HPCA: 
              Huntington's Disease in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HPCA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HPCA gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hpca1 , 5 hippocalcin1, 5 94.47(n)1
    100(a)1
      4 (62.88 cM)5
    154441  NM_001286083.11  NP_001273012.11 
     1291115705 
    chicken
    (Gallus gallus)
    Aves HPCA1 hippocalcin 86.18(n)
    94.3(a)
      419668  XM_001233528.3  XP_001233529.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia hpca1 hippocalcin 79.45(n)
    95.34(a)
      733559  NM_001044471.1  NP_001037936.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hpca1 hippocalcin 82.38(n)
    93.78(a)
      393696  NM_200723.1  NP_957017.1 


    ENSEMBL Gene Tree for HPCA (if available)
    TreeFam Gene Tree for HPCA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HPCA gene
    KCNIP32  KCNIP42  KCNIP12  GUCA1A2  RCVRN2  HPCAL12  GUCA1B2  NCALD2  
    KCNIP22  HPCAL42  NCS12  GUCA1C2  VSNL12  
    15 SIMAP similar genes for HPCA using alignment to 2 protein entries:     HPCA_HUMAN (see all proteins):
    DKFZp781K1922    HPCAL1    NCALD    VSNL1    HPCAL4    NCS1
    RCVRN    KCNIP1    KCNIP4    KCNIP3    GUCA1A    KCNIP2
    GUCA1B    DKFZp686E1183    GUCA1C

    Find genes that share paralogs with HPCA           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HPCA (see all 116)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1131774991,2
    F--33354113(+) CTCACG/ATCTGT 1 -- int12Minor allele frequency- A:0.50CSA 4
    rs1475124981,2
    C--33354273(+) AAAGCA/GTATGG 1 -- int10--------
    rs1126712751,2
    C--33354297(+) TGTGGG/AGCATG 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1400343531,2
    --33354303(+) GCATGC/GCATAG 1 -- int10--------
    rs115549571,2
    H--33354548(+) ACCTGC/TGAGAG 2 R * stg1 ese34Minor allele frequency- T:0.00NS EA 404
    rs115549581,2,,4
    H--33354562(+) ACAGAG/TTTCTC 2 E D mis1 ese36Minor allele frequency- T:0.00NS EA NA 404
    rs1905006421,2
    C--33354694(+) TTTGCC/TGAGCA 2 A syn10--------
    rs1824838901,2
    C--33354695(+) TTGCCA/GAGCAC 2 K E mis10--------
    rs2015040711,2
    C--33354793(+) CTGGAA/GCAGAA 2 E syn10--------
    rs115549601,2
    C,H--33354802(+) AAGCTC/TATGTG 2 L syn1 ese33Minor allele frequency- T:0.01NS NA 182

    HapMap Linkage Disequilibrium report for HPCA (33351595 - 33364042 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HPCA:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv212n71CNV Loss21882294
    nsv516302CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HPCA
    DNA2.0 Custom Variant and Variant Library Synthesis for HPCA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142622    OMIM disorders: --

    1 disease for HPCA:    
    About MalaCards
    ascending cholangitis

    1 disease from the University of Copenhagen DISEASES database for HPCA:
    Ascending cholangitis

    Find genes that share disorders with HPCA           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: HPCA (23 documents)

    Export disorders for HPCA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HPCA gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with HPCA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic structure and chromosomal mapping of the human and mouse hippocalcin genes. (PubMed id 9931466)1, 2, 3, 9 Masaki T.... Takamatsu K. (Gene 1998)
    2. Molecular cloning of human hippocalcin cDNA and chromosomal mapping of its gene. (PubMed id 8166736)1, 2, 3, 9 Takamatsu K.... Noguchi T. (Biochem. Biophys. Res. Commun. 1994)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Diminished hippocalcin expression in Huntington's disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons. (PubMed id 19686238)1, 9 Rudinskiy N....Luthi-Carter R. (J. Neurochem. 2009)
    5. NAIP interacts with hippocalcin and protects neurons against calcium-induced cell death through caspase-3-dependent and -independent pathways. (PubMed id 10899114)1, 9 Mercer E.A....Lindholm D. (EMBO J. 2000)
    6. Mixed lineage kinase 2 and hippocalcin are localized in Lewy bodies of Parkinson's disease. (PubMed id 19332348)1, 9 Nagao M. and Hayashi H. (J. Neurol. Sci. 2009)
    7. Differential use of myristoyl groups on neuronal calcium sensor proteins as a determinant of spatio-temporal aspects of Ca2+ signal transduction. (PubMed id 11836243)1, 9 O'Callaghan D.W....Burgoyne R.D. (J. Biol. Chem. 2002)
    8. High-affinity interaction of the N-terminal myristoylation motif of the neuronal calcium sensor protein hippocalcin with phosphatidylinositol 4,5-bisphosphate. (PubMed id 16053445)1, 9 O'Callaghan D.W....Burgoyne R.D. (Biochem. J. 2005)
    9. Dynamics and calcium sensitivity of the Ca2+/myristoyl switch protein hippocalcin in living cells. (PubMed id 14638856)1, 9 O'Callaghan D.W....Burgoyne R.D. (J. Cell Biol. 2003)
    10. A novel acetylation cycle of transcription co-activator Yes-associated protein that is downstream of Hippo pathway is triggered in response to SN2 alkylating agents. (PubMed id 22544757)1 Hata S....Nishina H. (J. Biol. Chem. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3208 HGNC: 5144 AceView: HPCA Ensembl:ENSG00000121905 euGenes: HUgn3208
    ECgene: HPCA H-InvDB: HPCA

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HPCA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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