Aliases for HP1BP3 Gene
Aliases for HP1BP3 Gene
External Ids for HP1BP3 Gene
- HGNC: 24973
- Entrez Gene: 50809
- Ensembl: ENSG00000127483
- OMIM: 616072
- UniProtKB: Q5SSJ5
Previous GeneCards Identifiers for HP1BP3 Gene
- GC01M020941
- GC01M021069
- GC01M019314
Summaries for HP1BP3 Gene
GeneCards Summary for HP1BP3 Gene
HP1BP3 (Heterochromatin Protein 1 Binding Protein 3) is a Protein Coding gene. GO annotations related to this gene include nucleosome binding.
UniProtKB/Swiss-Prot for HP1BP3 Gene
-
Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal(PubMed:25100860).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HP1BP3 Gene
Genomics for HP1BP3 Gene
Regulatory Elements for HP1BP3 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH01G021020 | 1.8 | FANTOM5 Ensembl ENCODE | 12.4 | -234.8 | -234821 | 2.6 | HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 | HP1BP3 MIR1256 EIF4G3 ECE1 CDA GC01P021023 RPS15AP6 |
| GH01G020730 | 1.1 | ENCODE | 14.1 | +55.0 | 55019 | 4.2 | PKNOX1 MLX AGO1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF766 ZNF143 | HP1BP3 EIF4G3 SH2D5 KIF17 |
| GH01G021148 | 1.5 | FANTOM5 Ensembl ENCODE | 9.3 | -363.6 | -363589 | 4.6 | ZSCAN4 INSM2 KLF17 ZNF2 ZEB1 ZNF121 GATA2 ZNF366 SCRT2 FOS | EIF4G3 MIR1256 HP1BP3 HSPE1P27 GC01M021094 |
| GH01G021182 | 0.8 | ENCODE | 17.2 | -395.6 | -395571 | 0.6 | ATF1 RB1 AGO1 KLF17 ZNF48 RAD21 ZEB1 ZNF335 EGR1 CREM | HP1BP3 MIR1256 EIF4G3 GC01M021203 |
| GH01G020738 | 0.8 | ENCODE | 15.3 | +47.8 | 47787 | 2.6 | FEZF1 BCL11B HIC1 POLR2A ZSCAN5C ZNF600 MAFK NFE2L2 ZNF362 ZNF501 | HP1BP3 EIF4G3 GC01P020738 |
- Transcription factor binding sites by QIAGEN in the HP1BP3 gene promoter:
Regulatory Element Products
Genomic Location for HP1BP3 Gene
- Chromosome:
- 1
- Start:
- 20,742,661 bp from pter
- End:
- 20,787,323 bp from pter
- Size:
- 44,663 bases
- Orientation:
- Minus strand
Genomic View for HP1BP3 Gene
- Cytogenetic band:
-
- 1p36.12 by Ensembl
- 1p36.12 by Entrez Gene
- 1p36.12 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HP1BP3 Gene
Proteins for HP1BP3 Gene
-
Protein details for HP1BP3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5SSJ5-HP1B3_HUMAN
- Recommended name:
- Heterochromatin protein 1-binding protein 3
- Protein Accession:
- Q5SSJ5
- A6NI71
- A8K5D7
- B3KMZ8
- B4E210
- Q05BI0
- Q5SSJ6
- Q5SWC6
- Q6PIM9
- Q8NDF0
- Q9UHY0
Protein attributes for HP1BP3 Gene
- Size:
- 553 amino acids
- Molecular mass:
- 61207 Da
- Quaternary structure:
-
- Interacts (via PxVxL motif) with CBX5 (via Trp-174).
- SequenceCaution:
-
- Sequence=AAF14871.1; Type=Frameshift; Positions=226, 237, 243; Evidence={ECO:0000305};
Protein Expression for HP1BP3 Gene
Post-translational modifications for HP1BP3 Gene
Other Protein References for HP1BP3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HP1BP3
-
Abcam antibodies for HP1BP3
- Invitrogen Antibodies for HP1BP3
- GeneTex RT1-A1 antibody for HP1BP3
- GeneTex HP1BP3 antibody for HP1BP3
Protein Products
-
OriGene Purified Proteins for HP1BP3
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-
Abcam proteins for HP1BP3
Assay Products
- antibodies-online Kits for HP1BP3: See all 5
No data available for DME Specific Peptides for HP1BP3 Gene
Domains & Families for HP1BP3 Gene
Protein Domains for HP1BP3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HP1BP3 Gene
Graphical View of Domain Structure for InterPro Entry
Q5SSJ5UniProtKB/Swiss-Prot:
HP1B3_HUMAN :- A central region that included the first H15 (linker histone H1/H5 globular) domain binds at the entry/exit site of the nucleosomal DNA.
- Domain:
-
- A central region that included the first H15 (linker histone H1/H5 globular) domain binds at the entry/exit site of the nucleosomal DNA.
No data available for Gene Families for HP1BP3 Gene
Function for HP1BP3 Gene
Molecular function for HP1BP3 Gene
- UniProtKB/Swiss-Prot Function:
- Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal(PubMed:25100860).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IDA | 20042602 |
| GO:0003682 | chromatin binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 20042602 |
| GO:0031491 | nucleosome binding | IDA | 20042602 |
Phenotypes for HP1BP3 Gene
- MGI mutant phenotypes for HP1BP3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HP1BP3:
Animal Models for HP1BP3 Gene
- MGI Knock Outs for HP1BP3:
-
- Hp1bp3 tm1a(EUCOMM)Wtsi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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ViGene Biosciences lentiviral particle packaged cDNA for HP1BP3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HP1BP3 gene
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CRISPR Products
-
OriGene CRISPR knockouts for HP1BP3
-
Santa Cruz Biotechnology (SCBT) CRISPR for HP1BP3
- GenScript: Design CRISPR guide RNA sequences for HP1BP3
miRNA for HP1BP3 Gene
- miRTarBase miRNAs that target HP1BP3
-
- hsa-mir-1-3p (MIRT024041)
- hsa-mir-193b-3p (MIRT041380)
- hsa-mir-29b-3p (MIRT048364)
- hsa-mir-382-3p (MIRT062248)
- hsa-mir-218-5p (MIRT440487)
- hsa-mir-7703 (MIRT714366)
- hsa-mir-6729-5p (MIRT714367)
- hsa-mir-4649-5p (MIRT714368)
- hsa-mir-4486 (MIRT714369)
- hsa-mir-4793-3p (MIRT714370)
- hsa-mir-1273g-3p (MIRT714371)
- hsa-mir-1228-3p (MIRT714372)
- hsa-mir-6757-3p (MIRT714373)
miRNA Products
- Search ViGene Biosciences for HP1BP3
Inhibitory RNA Products
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-
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Clone Products
-
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Cell Line Products
-
Horizon Cell Lines for HP1BP3
-
ViGene Biosciences adenoviral particle packaged cDNA for HP1BP3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HP1BP3 gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HP1BP3 Gene
Localization for HP1BP3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HP1BP3 Gene
- Nucleus. Chromosome. Note=localized in nuclei but not in nucleoli in interphase. Colocalized with chromosomes in mitosis, with a gradually increased during G1 progression and a maximum level during late G1 phase (G1/S). {ECO:0000269 PubMed:24830416}.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000786 | nucleosome | IEA | -- |
| GO:0005634 | nucleus | IDA | 24830416 |
| GO:0005694 | chromosome | IDA,IEA | 20042602 |
| GO:0016607 | nuclear speck | IDA | -- |
Pathways & Interactions for HP1BP3 Gene
Interacting Proteins for HP1BP3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006334 | nucleosome assembly | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IMP,IEA | 24830416 |
| GO:0042127 | regulation of cell proliferation | IMP | 24830416 |
| GO:0070828 | heterochromatin organization | IEA,IMP | 24830416 |
| GO:0071456 | cellular response to hypoxia | IDA | 25100860 |
No data available for Pathways by source and SIGNOR curated interactions for HP1BP3 Gene
Transcripts for HP1BP3 Gene
mRNA/cDNA for HP1BP3 Gene
- (11) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (532) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HP1BP3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HP1BP3
-
Santa Cruz Biotechnology (SCBT) CRISPR for HP1BP3
- GenScript: Design CRISPR guide RNA sequences for HP1BP3
miRNA Products
- Search ViGene Biosciences for HP1BP3
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HP1BP3
- Browse OriGene Inhibitory RNA Products For HP1BP3
-
ViGene Biosciences ready-to-package AAV shRNAs for HP1BP3 gene
Clone Products
-
OriGene ORF clones in human for HP1BP3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HP1BP3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: |
| ExUns: | 15b | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||
| SP2: | |||||||||||||
| SP3: | |||||||||||||
| SP4: | |||||||||||||
| SP5: | |||||||||||||
| SP6: | |||||||||||||
| SP7: | |||||||||||||
| SP8: | |||||||||||||
| SP9: | |||||||||||||
| SP10: | |||||||||||||
| SP11: | |||||||||||||
| SP12: | |||||||||||||
| SP13: | |||||||||||||
| SP14: | |||||||||||||
| SP15: | |||||||||||||
| SP16: |
Expression for HP1BP3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HP1BP3 Gene
NURSA nuclear receptor signaling pathways regulating expression of HP1BP3 Gene:
HP1BP3SOURCE GeneReport for Unigene cluster for HP1BP3 Gene:
Hs.142442Evidence on tissue expression from TISSUES for HP1BP3 Gene
- Nervous system(4.9)
- Liver(4.3)
- Blood(4.1)
- Intestine(2.4)
- Lung(2.4)
Primer Products
-
OriGene qPCR primer pairs for HP1BP3
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HP1BP3 Gene
Orthologs for HP1BP3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HP1BP3 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HP1BP3 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HP1BP3 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hp1bp3 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Hp1bp3 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | HP1BP3 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HP1BP3 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HP1BP3 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.6853 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hp1bp3 34 35 |
|
- Species where no ortholog for HP1BP3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HP1BP3 Gene
No data available for Paralogs for HP1BP3 Gene
Variants for HP1BP3 Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000037191 | -- | 20,760,565(+) | AGGCT(G/T)GGCAC | intron-variant | |
| rs1000126593 | -- | 20,774,759(+) | GTGGG(A/C)GGATC | intron-variant | |
| rs1000155993 | -- | 20,746,534(+) | TATGT(A/G/T)CTTTA | intron-variant | |
| rs1000156260 | -- | 20,785,661(+) | GGGTA(A/C)GGAGT | intron-variant | |
| rs1000238140 | -- | 20,763,133(+) | TAGCT(C/T)CTCCT | intron-variant |
Relevant External Links for HP1BP3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HP1BP3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HP1BP3 Gene
Disorders for HP1BP3 Gene
Relevant External Links for HP1BP3
No disorders were found for HP1BP3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HP1BP3 Gene
Publications for HP1BP3 Gene
- Profiling of the chromatin-associated proteome identifies HP1BP3 as a novel regulator of cell cycle progression. (PMID: 24830416) Dutta B. … Sze S.K. (Mol. Cell. Proteomics 2014) 2 3 4 64
- Quantitative profiling of chromatome dynamics reveals a novel role for HP1BP3 in hypoxia-induced oncogenesis. (PMID: 25100860) Dutta B. … Sze S.K. (Mol. Cell. Proteomics 2014) 3 4 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 64
- The middle region of an HP1-binding protein, HP1-BP74, associates with linker DNA at the entry/exit site of nucleosomal DNA. (PMID: 20042602) Hayashihara K. … Fukui K. (J. Biol. Chem. 2010) 3 4 64
Products for HP1BP3 Gene
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- Novus Biologicals Antibodies for HP1BP3
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- Abcam proteins for HP1BP3
- Search for Assays for HP1BP3 at Abcam
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- GeneTex RT1-A1 antibody for HP1BP3
- GeneTex HP1BP3 antibody for HP1BP3
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- ViGene Biosciences adenoviral particle packaged cDNA for HP1BP3 gene
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- VectorBuilder custom plasmid, inducible vectors for HP1BP3
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HP1BP3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
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