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Aliases for HP1BP3 Gene

Aliases for HP1BP3 Gene

  • Heterochromatin Protein 1 Binding Protein 3 2 3
  • Heterochromatin Protein 1, Binding Protein 3 2 3 5
  • Protein HP1-BP74 4
  • HP1-BP74 3
  • HP1BP74 3

External Ids for HP1BP3 Gene

Previous GeneCards Identifiers for HP1BP3 Gene

  • GC01M020941
  • GC01M021069
  • GC01M019314

Summaries for HP1BP3 Gene

GeneCards Summary for HP1BP3 Gene

HP1BP3 (Heterochromatin Protein 1 Binding Protein 3) is a Protein Coding gene. GO annotations related to this gene include nucleosome binding.

UniProtKB/Swiss-Prot for HP1BP3 Gene

  • Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal(PubMed:25100860).

Gene Wiki entry for HP1BP3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HP1BP3 Gene

Genomics for HP1BP3 Gene

Regulatory Elements for HP1BP3 Gene

Enhancers for HP1BP3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HP1BP3 on UCSC Golden Path with GeneCards custom track

Promoters for HP1BP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HP1BP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for HP1BP3 Gene

Chromosome:
1
Start:
20,742,661 bp from pter
End:
20,787,323 bp from pter
Size:
44,663 bases
Orientation:
Minus strand

Genomic View for HP1BP3 Gene

Genes around HP1BP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HP1BP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HP1BP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HP1BP3 Gene

Proteins for HP1BP3 Gene

  • Protein details for HP1BP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SSJ5-HP1B3_HUMAN
    Recommended name:
    Heterochromatin protein 1-binding protein 3
    Protein Accession:
    Q5SSJ5
    Secondary Accessions:
    • A6NI71
    • A8K5D7
    • B3KMZ8
    • B4E210
    • Q05BI0
    • Q5SSJ6
    • Q5SWC6
    • Q6PIM9
    • Q8NDF0
    • Q9UHY0

    Protein attributes for HP1BP3 Gene

    Size:
    553 amino acids
    Molecular mass:
    61207 Da
    Quaternary structure:
    • Interacts (via PxVxL motif) with CBX5 (via Trp-174).
    SequenceCaution:
    • Sequence=AAF14871.1; Type=Frameshift; Positions=226, 237, 243; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HP1BP3 Gene

    Alternative splice isoforms for HP1BP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HP1BP3 Gene

Proteomics data for HP1BP3 Gene at MOPED

Post-translational modifications for HP1BP3 Gene

  • Ubiquitination at Lys 14, Lys 131, Lys 291, and Lys 302
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HP1BP3 Gene

Domains & Families for HP1BP3 Gene

Protein Domains for HP1BP3 Gene

Graphical View of Domain Structure for InterPro Entry

Q5SSJ5

UniProtKB/Swiss-Prot:

HP1B3_HUMAN :
  • A central region that included the first H15 (linker histone H1/H5 globular) domain binds at the entry/exit site of the nucleosomal DNA.
Domain:
  • A central region that included the first H15 (linker histone H1/H5 globular) domain binds at the entry/exit site of the nucleosomal DNA.
  • Contains 3 H15 (linker histone H1/H5 globular) domains.
genes like me logo Genes that share domains with HP1BP3: view

No data available for Gene Families for HP1BP3 Gene

Function for HP1BP3 Gene

Molecular function for HP1BP3 Gene

UniProtKB/Swiss-Prot Function:
Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal(PubMed:25100860).
genes like me logo Genes that share phenotypes with HP1BP3: view

Animal Models for HP1BP3 Gene

MGI Knock Outs for HP1BP3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HP1BP3 Gene

Localization for HP1BP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HP1BP3 Gene

Nucleus. Chromosome. Note=localized in nuclei but not in nucleoli in interphase. Colocalized with chromosomes in mitosis, with a gradually increased during G1 progression and a maximum level during late G1 phase (G1/S). {ECO:0000269 PubMed:24830416}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HP1BP3 Gene COMPARTMENTS Subcellular localization image for HP1BP3 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for HP1BP3 Gene

Pathways & Interactions for HP1BP3 Gene

SuperPathways for HP1BP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HP1BP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042127 regulation of cell proliferation IMP 24830416
GO:0070828 heterochromatin organization IMP 24830416
GO:0071456 cellular response to hypoxia IDA 25100860
genes like me logo Genes that share ontologies with HP1BP3: view

No data available for Pathways by source and SIGNOR curated interactions for HP1BP3 Gene

Drugs & Compounds for HP1BP3 Gene

No Compound Related Data Available

Transcripts for HP1BP3 Gene

Unigene Clusters for HP1BP3 Gene

Heterochromatin protein 1, binding protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HP1BP3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a ·
SP1:
SP2: - - - - - - - - -
SP3: - - - - - - - -
SP4: - - -
SP5: - - - - -
SP6:
SP7: -
SP8: - - - - -
SP9: - - - - - - - -
SP10: -
SP11: - - - - -
SP12:
SP13: -
SP14: - - - -
SP15:
SP16:

ExUns: 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for HP1BP3 Gene

GeneLoc Exon Structure for
HP1BP3
ECgene alternative splicing isoforms for
HP1BP3

Expression for HP1BP3 Gene

mRNA expression in normal human tissues for HP1BP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HP1BP3 Gene

This gene is overexpressed in Tlymphocyte (10.3) and Nasal epithelium (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HP1BP3 Gene



SOURCE GeneReport for Unigene cluster for HP1BP3 Gene Hs.142442

genes like me logo Genes that share expression patterns with HP1BP3: view

Protein tissue co-expression partners for HP1BP3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HP1BP3 Gene

Orthologs for HP1BP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HP1BP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HP1BP3 35
  • 92.71 (n)
  • 94.03 (a)
HP1BP3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HP1BP3 35
  • 94.09 (n)
  • 96.02 (a)
HP1BP3 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hp1bp3 35
  • 86.24 (n)
  • 88.73 (a)
Hp1bp3 16
Hp1bp3 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HP1BP3 35
  • 99.76 (n)
  • 100 (a)
HP1BP3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hp1bp3 35
  • 86.99 (n)
  • 88.93 (a)
oppossum
(Monodelphis domestica)
Mammalia HP1BP3 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 83 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
chicken
(Gallus gallus)
Aves HP1BP3 35
  • 76.66 (n)
  • 76.97 (a)
HP1BP3 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HP1BP3 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6853 35
zebrafish
(Danio rerio)
Actinopterygii hp1bp3 35
  • 55.64 (n)
  • 47.62 (a)
hp1bp3 36
  • 37 (a)
OneToOne
Species with no ortholog for HP1BP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HP1BP3 Gene

ENSEMBL:
Gene Tree for HP1BP3 (if available)
TreeFam:
Gene Tree for HP1BP3 (if available)

Paralogs for HP1BP3 Gene

No data available for Paralogs for HP1BP3 Gene

Variants for HP1BP3 Gene

Sequence variations from dbSNP and Humsavar for HP1BP3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs475658 -- 20,777,465(+) TATTT(A/T)TTTTT intron-variant
rs490879 -- 20,750,278(-) TCTCG(A/G)ACTCC intron-variant
rs495522 -- 20,779,501(+) CTGCA(C/T)TGATC intron-variant
rs589755 -- 20,773,353(+) GCAGA(A/G)CAAGA intron-variant
rs559177 -- 20,771,090(+) TTATT(A/G)AACTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HP1BP3 Gene

Variant ID Type Subtype PubMed ID
nsv834369 CNV Loss 17160897
nsv870827 CNV Gain 21882294
nsv871858 CNV Loss 21882294
esv2745019 CNV Deletion 23290073
nsv5742 CNV Insertion 18451855

Variation tolerance for HP1BP3 Gene

Residual Variation Intolerance Score: 5.86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.58; 30.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HP1BP3 Gene

HapMap Linkage Disequilibrium report
HP1BP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HP1BP3 Gene

Disorders for HP1BP3 Gene

Relevant External Links for HP1BP3

Genetic Association Database (GAD)
HP1BP3
Human Genome Epidemiology (HuGE) Navigator
HP1BP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HP1BP3

No disorders were found for HP1BP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HP1BP3 Gene

Publications for HP1BP3 Gene

  1. Profiling of the chromatin-associated proteome identifies HP1BP3 as a novel regulator of cell cycle progression. (PMID: 24830416) Dutta B. … Sze S.K. (Mol. Cell. Proteomics 2014) 2 3 4 67
  2. HP1BP3 is a novel histone H1 related protein with essential roles in viability and growth. (PMID: 25662603) Garfinkel B.P. … Orly J. (Nucleic Acids Res. 2015) 3
  3. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for HP1BP3 Gene

Sources for HP1BP3 Gene

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