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HP1BP3 Gene

protein-coding   GIFtS: 52
GCID: GC01M021069

Heterochromatin Protein 1, Binding Protein 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heterochromatin Protein 1, Binding Protein 31 2
HP1-BP742
Heterochromatin Protein 1-Binding Protein 32
Protein HP1-BP743

External Ids:    HGNC: 249731   Entrez Gene: 508092   Ensembl: ENSG000001274837   UniProtKB: Q5SSJ53   

Export aliases for HP1BP3 gene to outside databases

Previous GC identifers: GC01M020815 GC01M020941 GC01M019314


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HP1BP3 Gene:
HP1BP3 (heterochromatin protein 1, binding protein 3) is a protein-coding gene. Diseases associated with HP1BP3 include retinopathy of prematurity, and schizophrenia.

UniProtKB/Swiss-Prot: HP1B3_HUMAN, Q5SSJ5
Function: Component of heterochromatin, may be involved in chromatin structure and function (By similarity)

Gene Wiki entry for HP1BP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HP1BP3 gene promoter:
         STAT5B   TBP   HOXA3   AML1a   AP-4   Egr-2   SRY   Cart-1   NF-kappaB1   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHP1BP3 promoter sequence
   Search Chromatin IP Primers for HP1BP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HP1BP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.12   Ensembl cytogenetic band:  1p36.12   HGNC cytogenetic band: 1p36.12

HP1BP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HP1BP3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M021069:  view genomic region     (about GC identifiers)

Start:
21,069,154 bp from pter      End:
21,113,816 bp from pter
Size:
44,663 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HP1B3_HUMAN, Q5SSJ5 (See protein sequence)
Recommended Name: Heterochromatin protein 1-binding protein 3  
Size: 553 amino acids; 61207 Da
Subunit: Interacts with CBX5 (By similarity)
Sequence caution: Sequence=AAF14871.1; Type=Frameshift; Positions=226, 237, 243;
1 PDB 3D structure from and Proteopedia for HP1BP3:
2RQP (3D)    
Secondary accessions: A6NI71 A8K5D7 B3KMZ8 B4E210 Q05BI0 Q5SSJ6 Q5SWC6 Q6PIM9 Q8NDF0 Q9UHY0
Alternative splicing: 4 isoforms:  Q5SSJ5-1   Q5SSJ5-2   Q5SSJ5-3   Q5SSJ5-5   

Explore the universe of human proteins at neXtProt for HP1BP3: NX_Q5SSJ5

Explore proteomics data for HP1BP3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys14, Lys131, Lys291, Lys302
  • Modification sites at PhosphoSitePlus

  • See HP1BP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057371.2  
    ENSEMBL proteins: 
     ENSP00000312625   ENSP00000364142   ENSP00000391721   ENSP00000403039   ENSP00000402754  
     ENSP00000391281   ENSP00000364139   ENSP00000402096   ENSP00000397656   ENSP00000405362  
     ENSP00000401874  

    HP1BP3 Human Recombinant Protein Products:

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    Novus Biologicals HP1BP3 Protein
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    Cloud-Clone Corp. Proteins for HP1BP3

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    Cloud-Clone Corp. CLIAs for HP1BP3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR005818 Histone_H1/H5_H15

    Graphical View of Domain Structure for InterPro Entry Q5SSJ5

    ProtoNet protein and cluster: Q5SSJ5

    1 Blocks protein domain: IPB005818 Histone H1/H5

    UniProtKB/Swiss-Prot: HP1B3_HUMAN, Q5SSJ5
    Similarity: Contains 3 H15 (linker histone H1/H5 globular) domains


    HP1BP3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HP1B3_HUMAN, Q5SSJ5
    Function: Component of heterochromatin, may be involved in chromatin structure and function (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
         
    HP1BP3 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hp1bp3):
     cardiovascular system  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  skeleton 

    HP1BP3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HP1BP3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HP1BP3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HP1BP3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HP1BP3

    miRNA
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    miRTarBase miRNAs that target HP1BP3:
    hsa-mir-29b-3p (MIRT048364), hsa-mir-1 (MIRT024041), hsa-mir-193b-3p (MIRT041380)

    Block miRNA regulation of human, mouse, rat HP1BP3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HP1BP3 (see all 74):
    hsa-miR-579 hsa-miR-323-3p hsa-miR-549 hsa-miR-607 hsa-miR-520e hsa-miR-106a hsa-miR-208b hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidHP1BP3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HP1BP3

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    Sino Biological Human cDNA Clone for HP1BP3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HP1BP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HP1BP3

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HP1BP3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HP1B3_HUMAN, Q5SSJ5: Nucleus (By similarity). Chromosome (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    HP1BP3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HP1BP3
    Interactions:

        Search GeneGlobe Interaction Network for HP1BP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for HP1BP3 (Q5SSJ53 ENSP000003126254) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    RNF2Q994963, ENSP000003564804I2D: score=1 STRING: ENSP00000356480
    SUMO2P619563, ENSP000004059654I2D: score=1 STRING: ENSP00000405965
    GABARAPO951663I2D: score=1 
    PDPK1O155303I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly IEA--

    HP1BP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HP1BP3 (HP1B3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HP1BP3 gene: 
    NM_016287.3  

    Unigene Cluster for HP1BP3:

    Heterochromatin protein 1, binding protein 3
    Hs.142442  [show with all ESTs]
    Unigene Representative Sequence: BC045660
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000312239(uc010odf.1 uc001bdy.1 uc001bdw.1 uc010odh.1)
    ENST00000375003(uc010odg.1) ENST00000488722 ENST00000491748 ENST00000419948
    ENST00000438032(uc001bea.2) ENST00000424732 ENST00000417710 ENST00000487117
    ENST00000375000(uc001beb.3) ENST00000437575 ENST00000419490 ENST00000414993
    ENST00000443615
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate HP1BP3 (see all 74):
    hsa-miR-579 hsa-miR-323-3p hsa-miR-549 hsa-miR-607 hsa-miR-520e hsa-miR-106a hsa-miR-208b hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidHP1BP3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for HP1BP3
    Predesigned siRNA for gene silencing in human, mouse, rat HP1BP3
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    GenScript: all cDNA clones in your preferred vector: HP1BP3 (NM_016287)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HP1BP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HP1BP3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for HP1BP3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HP1BP3
      QuantiTect SYBR Green Assays in human, mouse, rat HP1BP3
      QuantiFast Probe-based Assays in human, mouse, rat HP1BP3

    Additional mRNA sequence: 

    AF113534.1 AK023129.1 AK025754.1 AK124416.1 AK291252.1 AK303456.1 AK304065.1 AL833978.1 
    BC007118.1 BC032139.2 BC045660.1 BC053327.1 BC056233.1 CR749652.1 

    Selected DOTS entries (see all 27):

    DT.97796504  DT.449317  DT.92447690  DT.91857347  DT.101985290  DT.92447679  DT.100758703  DT.121370071 
    DT.121370108  DT.429853  DT.121370097  DT.97804797  DT.99948420  DT.101985288  DT.92447683  DT.102834014 
    DT.121370078  DT.121370084  DT.121370127  DT.95301197  DT.100717340  DT.70100849  DT.95164532  DT.102834017 

    Selected AceView cDNA sequences (see all 532):

    CD674109 CF132498 AI567555 AI367922 CK825042 CF786102 BM544907 AI570147 
    BM927270 BU190318 BQ951945 AW514495 BM994537 AA988096 AI589401 AI806238 
    CR599334 AU132642 BF589081 BM703895 AI418083 AI521532 AU134327 BU541538 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HP1BP3 (see all 16)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a ·
    SP1:                                                                                                                                                            
    SP2:              -     -     -     -                       -           -     -     -     -                                                                     
    SP3:                    -     -     -                       -           -     -     -     -                                                                     
    SP4:                                -                       -           -                                                                                       
    SP5:                                                        -           -     -     -     -                                                                     

    ExUns: 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for HP1BP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HP1BP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATTTTAAA
    HP1BP3 Expression
    About this image


    HP1BP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    HP1BP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HP1BP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.142442
        Custom PCR Arrays for HP1BP3
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat HP1BP3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HP1BP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HP1BP3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hp1bp31 , 5 heterochromatin protein 1, binding protein 31, 5 86.24(n)1
    88.73(a)1
      4 (70.03 cM)5
    154411  NM_001285479.11  NP_001272408.11 
     1382162965 
    chicken
    (Gallus gallus)
    Aves HP1BP31 heterochromatin protein 1, binding protein 3 76.66(n)
    76.97(a)
      425543  NM_001006560.1  NP_001006560.1 
    lizard
    (Anolis carolinensis)
    Reptilia HP1BP36
    heterochromatin protein 1, binding protein 3
    67(a)
    1 ↔ 1
    GL343609.1(69052-87072)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.68532 Transcribed sequence with moderate similarity to protein more 76.09(n)    CF264174.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hp1bp31 heterochromatin protein 1, binding protein 3 55.64(n)
    47.62(a)
      558102  NM_001199725.1  NP_001186654.1 


    ENSEMBL Gene Tree for HP1BP3 (if available)
    TreeFam Gene Tree for HP1BP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HP1BP3 (see all 1022)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1882768201,2
    --21068905(+) ATTGTA/CCTCTA 1 -- int10--------
    rs1442784391,2
    C--21068907(+) TGTACC/TCTATG 1 -- int10--------
    rs168245721,2
    C,F--21068962(+) CCTTTG/CATTCA 1 -- int16Minor allele frequency- C:0.01NA WA 264
    rs1465896441,2
    --21068986(+) ATTCAA/GTGTAT 1 -- int10--------
    rs1911382731,2
    --21069128(+) CTGAGA/GATATA 1 -- int10--------
    rs121218071,2
    C,F,H--21069129(+) TGAGGA/CTATAC 1 -- int124Minor allele frequency- C:0.35NA NS EA WA CSA 2486
    rs2021657341,2
    C--21069340(-) CTGGGA/GANNNN 1 -- ut310--------
    rs1998836701,2
    --21069615(+) TTTTC-/TTTTTT 1 -- ut310--------
    rs1847715861,2
    --21069694(+) AAAAAA/CCCCAC 1 -- ut310--------
    rs1891759071,2
    --21069738(+) CTGTAC/TATTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for HP1BP3 (21069154 - 21113816 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for HP1BP3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745019CNV Deletion23290073
    nsv5742CNV Insertion18451855
    nsv834369CNV Loss17160897
    nsv871858CNV Loss21882294
    nsv870827CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    6 diseases for HP1BP3:    
    About MalaCards
    retinopathy of prematurity    schizophrenia    retinitis    hiv-1
    multiple myeloma    myeloma


    HP1BP3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): HP1BP3
    Human Genome Epidemiology (HuGE) Navigator: HP1BP3 (2 documents)

    Export disorders for HP1BP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HP1BP3 gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with HP1BP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    6. The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. (PubMed id 23940030)1 Teixeira F.R....Gomes M.D. (J. Biol. Chem. 2013)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    10. A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells. (PubMed id 22412018)1 Roux K.J.... Burke B. (J. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 50809 HGNC: 24973 AceView: HP1-BP74 Ensembl:ENSG00000127483 euGenes: HUgn50809
    ECgene: HP1BP3 H-InvDB: HP1BP3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HP1BP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for HP1BP3 gene:
    Search GeneIP for patents involving HP1BP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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