Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HP1BP3 Gene

protein-coding   GIFtS: 46
GCID: GC01M021069

heterochromatin protein 1, binding protein 3

 Explore 3 diseases affiliated with
HP1BP3 via our new
 Human Malady Compendium 
Biological research products
for HP1BP3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Heterochromatin Protein 1, Binding Protein 31 2
HP1-BP741 2
Heterochromatin Protein 1-Binding Protein 32
Protein HP1-BP743

External Ids:    HGNC: 249731   Entrez Gene: 508092   Ensembl: ENSG000001274837   UniProtKB: Q5SSJ53   

Export aliases for HP1BP3 gene to outside databases

Previous GC identifers: GC01M020815 GC01M020941 GC01M019314


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: HP1B3_HUMAN, Q5SSJ5
Function: Component of heterochromatin, may be involved in chromatin structure and function (By similarity)

Gene Wiki entry for HP1BP3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HP1BP3 gene promoter:
         STAT5B   TBP   HOXA3   AML1a   AP-4   Egr-2   SRY   Cart-1   NF-kappaB1   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHP1BP3 promoter sequence
   Search SABiosciences Chromatin IP Primers for HP1BP3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HP1BP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.12   Ensembl cytogenetic band:  1p36.12   HGNC cytogenetic band: 1p36.12

HP1BP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HP1BP3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M021069:  view genomic region     (about GC identifiers)

Start:
21,069,154 bp from pter      End:
21,113,816 bp from pter
Size:
44,663 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HP1B3_HUMAN, Q5SSJ5 (See protein sequence)
Recommended Name: Heterochromatin protein 1-binding protein 3  
Size: 553 amino acids; 61207 Da
Subunit: Interacts with CBX5 (By similarity)
Subcellular location: Nucleus (By similarity). Chromosome (By similarity)
Sequence caution: Sequence=AAF14871.1; Type=Frameshift; Positions=226, 237, 243;
1 PDB 3D structure from and Proteopedia for HP1BP3:
2RQP (3D)    
Secondary accessions: A6NI71 A8K5D7 B3KMZ8 B4E210 Q05BI0 Q5SSJ6 Q5SWC6 Q6PIM9 Q8NDF0 Q9UHY0
Alternative splicing: 4 isoforms:  Q5SSJ5-1   Q5SSJ5-2   Q5SSJ5-3   Q5SSJ5-5   

Explore the universe of human proteins at neXtProt for HP1BP3: NX_Q5SSJ5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5SSJ5

  • HP1BP3 Protein expression data from MOPED and PaxDb:    About this image 
    HP1BP3 Protein Expression
    REFSEQ proteins: NP_057371.2  
    ENSEMBL proteins: 
     ENSP00000312625   ENSP00000364142   ENSP00000364143   ENSP00000391721   ENSP00000403039  
     ENSP00000402754   ENSP00000391281   ENSP00000364139   ENSP00000402096   ENSP00000397656  
     ENSP00000405362   ENSP00000401874  

    Human Recombinant Protein Products for HP1BP3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: HP1BP3
    OriGene Custom Protein Services for HP1BP3 
    GenScript Custom Purified and Recombinant Proteins Services for HP1BP3
    Novus Biologicals HP1BP3 Protein
    Novus Biologicals HP1BP3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HP1BP3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome IEA--
    GO:0005634nucleus IEA--

    HP1BP3 for ontologies           About GeneDecksing



    HP1BP3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HP1BP3 
    GenScript Custom Superior Antibodies Services for HP1BP3
    Novus Biologicals HP1BP3 Antibodies
    Abcam antibodies for HP1BP3 
    Uscn Antibodies for HP1BP3
    Search ThermoFisher Antibodies for HP1BP3

    Assay Products for HP1BP3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HP1BP3
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for HP1BP3


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    HP1BP3 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom
     IPR005818 Histone_H1/H5

    Graphical View of Domain Structure for InterPro Entry Q5SSJ5

    ProtoNet protein and cluster: Q5SSJ5

    1 Blocks protein family: IPB005818 Histone H1/H5

    UniProtKB/Swiss-Prot: HP1B3_HUMAN, Q5SSJ5
    Similarity: Contains 3 H15 (linker histone H1/H5 globular) domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HP1B3_HUMAN, Q5SSJ5
    Function: Component of heterochromatin, may be involved in chromatin structure and function (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
         
    HP1BP3 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hp1bp3):
     cardiovascular system  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  skeleton 

    HP1BP3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HP1BP3 

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: HP1BP3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HP1BP3
    8/74 QIAGEN miScript miRNA Assays for microRNAs that regulate HP1BP3 (see all 74):
    hsa-miR-579 hsa-miR-323-3p hsa-miR-549 hsa-miR-607 hsa-miR-520e hsa-miR-106a hsa-miR-208b hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidHP1BP3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HP1BP3 (see all 7)
    OriGene shRNA RFP: HP1BP3
    OriGene siRNA: HP1BP3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HP1BP3
    Sirion Biotech Custom design and validation of potent shRNA sequences against HP1BP3 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HP1BP3
    Sirion Biotech Customized adenovirus for overexpression of HP1BP3 
    Sirion Biotech Customized adenovirus for potent knockdown of HP1BP3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HP1BP3 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HP1BP3 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HP1BP3 (NM_016287)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HP1BP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HP1BP3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HP1BP3
    Search LifeMap BioReagents cell lines for HP1BP3
    Sirion Biotech Customized stable knockdown cell line services for HP1BP3 
    Sirion Biotech Customized inducible knockdown cell line services for HP1BP3
    Sirion Biotech Customized stable overexpressing cell line services for HP1BP3
    Sirion Biotech Customized inducible overexpressing cell line services for HP1BP3

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HP1BP3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HP1BP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/16 Interacting proteins for HP1BP3 (Q5SSJ53 ENSP000003126254) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    SUMO2P619563, ENSP000004059654I2D: score=1 STRING: ENSP00000405965
    GABARAPO951663I2D: score=1 
    PDPK1O155303I2D: score=1 
    PRKAA1Q131313I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly IEA--

    HP1BP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HP1BP3
    Search CenterWatch for drugs/clinical trials and news about HP1BP3 / HP1B3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HP1BP3 gene: 
    NM_016287.3  

    Unigene Cluster for HP1BP3:

    Heterochromatin protein 1, binding protein 3
    Hs.142442  [show with all ESTs]
    Unigene Representative Sequence: BC045660
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000312239(uc010odf.1 uc001bdy.1 uc001bdw.1 uc010odh.1)
    ENST00000375003(uc010odg.1) ENST00000375004(uc001bdv.1) ENST00000488722
    ENST00000491748 ENST00000419948 ENST00000438032(uc001bea.2) ENST00000424732
    ENST00000417710 ENST00000487117 ENST00000375000(uc001beb.3) ENST00000437575
    ENST00000419490 ENST00000414993 ENST00000443615

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: HP1BP3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HP1BP3
    8/74 QIAGEN miScript miRNA Assays for microRNAs that regulate HP1BP3 (see all 74):
    hsa-miR-579 hsa-miR-323-3p hsa-miR-549 hsa-miR-607 hsa-miR-520e hsa-miR-106a hsa-miR-208b hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidHP1BP3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HP1BP3 (see all 7)
    OriGene shRNA RFP: HP1BP3
    OriGene siRNA: HP1BP3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HP1BP3
    Sirion Biotech Custom design and validation of potent shRNA sequences against HP1BP3 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HP1BP3 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HP1BP3 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HP1BP3 (NM_016287)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HP1BP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HP1BP3 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HP1BP3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HP1BP3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HP1BP3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HP1BP3

    Additional cDNA sequence: 

    AF113534.1 AK023129.1 AK025754.1 AK124416.1 AK291252.1 AK303456.1 AK304065.1 AL833978.1 
    BC007118.1 BC032139.2 BC045660.1 BC053327.1 BC056233.1 CR749652.1 

    24/25 DOTS entries (see all 25):

    DT.97796504  DT.449317  DT.92447690  DT.101985290  DT.92447679  DT.100758703  DT.91857347  DT.121370071 
    DT.121370108  DT.429853  DT.121370097  DT.97804797  DT.99948420  DT.101985288  DT.92447683  DT.102834014 
    DT.121370078  DT.95301197  DT.100717340  DT.121370084  DT.70100849  DT.95164532  DT.102834017  DT.91933691 

    24/532 AceView cDNA sequences (see all 532):

    AA282654 BG676488 AA311576 BX489741 CA447275 AI168647 AI418083 BQ068219 
    AI570147 BM548717 AU130946 AA382929 AI167733 BM718975 AW161953 BG122077 
    AW057722 CK825042 AV656570 BM763644 AI735125 AA458527 CD674108 AA053286 

    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for HP1BP3 (see all 16)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a ·
    SP1:                                                                                                                                                            
    SP2:              -     -     -     -                       -           -     -     -     -                                                                     
    SP3:                    -     -     -                       -           -     -     -     -                                                                     
    SP4:                                -                       -           -                                                                                       
    SP5:                                                        -           -     -     -     -                                                                     

    ExUns: 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for HP1BP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HP1BP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAATTTTAAA
    HP1BP3 Expression
    About this image
    See HP1BP3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HP1BP3

    SOURCE GeneReport for Unigene cluster: Hs.142442
        SABiosciences Custom PCR Arrays for HP1BP3

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HP1BP3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HP1BP3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HP1BP3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HP1BP3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HP1BP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for HP1BP3 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hp1bp31 , 5 heterochromatin protein 1, binding protein 31, 5 87.84(n)1
    90.74(a)1
      4 (70.03 cM)5
    154411  NM_001122897.11  NP_001116369.11 
     1382162965 
    chicken
    (Gallus gallus)
    Aves HP1BP31 heterochromatin protein 1, binding protein 3 77.88(n)
    78.43(a)
      425543  NM_001006560.1  NP_001006560.1 
    lizard
    (Anolis carolinensis)
    Reptilia HP1BP36
    --
    68(a)
    1 ↔ 1
    GL343609.1(69148-87155)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.68532 Transcribed sequence with moderate similarity to protein more 76.09(n)    CF264174.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hp1bp31 heterochromatin protein 1, binding protein 3 57.93(n)
    49.48(a)
      558102  NM_001199725.1  NP_001186654.1 


    ENSEMBL Gene Tree for HP1BP3 (if available)
    TreeFam Gene Tree for HP1BP3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/846 NCBI SNPs in HP1BP3 are shown (see all 846    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1882768201,2
    --21068905(+) ATTGTA/CCTCTA 1 -- int10--------
    rs1442784391,2
    --21068907(+) TGTACC/TCTATG 1 -- int10--------
    rs168245721,2
    C--21068962(+) CCTTTG/CATTCA 1 -- int16Minor allele frequency- C:0.01NA WA 264
    rs1465896441,2
    --21068986(+) ATTCAA/GTGTAT 1 -- int10--------
    rs1911382731,2
    --21069128(+) CTGAGA/GATATA 1 -- int10--------
    rs121218071,2
    C,F,H--21069129(+) TGAGGA/CTATAC 1 -- int124Minor allele frequency- C:0.35NA NS EA WA CSA 2486
    rs2021657341,2
    C--21069340(-) CTGGGA/GANNNN 1 -- ut310--------
    rs1998836701,2
    --21069615(+) TTTTC-/TTTTTT 1 -- ut310--------
    rs354333291,2
    C--21069616(+) TTTTTT/-AATAT 1 -- ut311Minor allele frequency- -:0.00NA 2
    rs1847715861,2
    --21069694(+) AAAAAA/CCCCAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for HP1BP3 (21069154 - 21113816 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HP1BP3: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HP1BP3
    DNA2.0 Custom Variant and Variant Library Synthesis for HP1BP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    HP1BP3 for disorders           About GeneDecksing

    3 diseases for HP1BP3:    About MalaCards
    retinopathy of prematurity    retinitis    schizophrenia

    Human Genome Epidemiology (HuGE) Navigator: HP1BP3 (2 documents)

    Export disorders for HP1BP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HP1BP3 gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with HP1BP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    4. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    5. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    6. Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). (PubMed id 21907836)1 Zhao J....Yang P. (2011)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
    10. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 50809 HGNC: 24973 AceView: HP1-BP74 Ensembl:ENSG00000127483 euGenes: HUgn50809
    ECgene: HP1BP3 H-InvDB: HP1BP3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HP1BP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HP1BP3 gene:
    Search GeneIP for patents involving HP1BP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for HP1BP3  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HP1BP3   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HP1BP3  
     OriGene Protein Over-expression Lysate for HP1BP3   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for HP1BP3   OriGene 3'-UTR Clone for HP1BP3  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HP1BP3   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HP1BP3  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HP1BP3   OriGene Custom Protein Services for HP1BP3  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HP1BP3
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HP1BP3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HP1BP3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HP1BP3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HP1BP3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HP1BP3
     GenScript Custom Purified and Recombinant Proteins Services for HP1BP3 GenScript cDNA clones with any tag delivered in your preferred vector for HP1BP3
     GenScript Custom Assay Services for HP1BP3 GenScript Custom Superior Antibodies Services for HP1BP3
     GenScript Custom overexpressing Cell Line Services for HP1BP3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HP1BP3 promoter
     Search Chromatin IP Primers for HP1BP3
     RT2 qPCR Primer Assay in human, mouse, rat HP1BP3
     Search GNC Networks for HP1BP3
     SABiosciences Custom PCR Arrays for HP1BP3
     Search Tocris compounds for HP1BP3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     HP1BP3 antibodies
     HP1BP3 proteins
     HP1BP3 lysates
     Antibodies for HP1BP3
     See all of Abcam's Antibodies, Kits and Proteins for HP1BP3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     HP1BP3 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for HP1BP3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HP1BP3
     SwitchGear 3'UTR luciferase reporter plasmids for HP1BP3
     SwitchGear Promoter luciferase reporter plasmids for HP1BP3
     Search ThermoFisher Antibodies for HP1BP3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HP1BP3
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HP1BP3
    Sirion Biotech Customized:
     stable knockdown cell line services for HP1BP3
     inducible knockdown cell line services for HP1BP3
     design and validation of potent shRNA sequences against HP1BP3
     adenovirus for potent knockdown of HP1BP3
     adenovirus for overexpression of HP1BP3
     stable overexpressing cell line services for HP1BP3
     inducible overexpressing cell line services for HP1BP3
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HP1BP3 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4