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HOXD9 Gene

protein-coding   GIFtS: 51
GCID: GC02P176987

Homeobox D9

(Previous name: homeo box D9)
(Previous symbols: HOX4C, HOX4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Homeobox D91 2     Homeobox Protein Hox-5.22 3
HOX4C1 2 3 5     Hox-4.32
HOX41 2     Hox-5.22
Homeo Box D91 2     Homeobox Protein Hox-D92
Homeobox Protein Hox-4C2 3     Hox-4.3, Mouse, Homolog Of2

External Ids:    HGNC: 51401   Entrez Gene: 32352   Ensembl: ENSG000001287097   OMIM: 1429825   UniProtKB: P283563   

Export aliases for HOXD9 gene to outside databases

Previous GC identifers: GC02P175040 GC02P175648 GC02P176951 GC02P177189 GC02P176812 GC02P176695 GC02P168864


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HOXD9 Gene:
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of
transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals
possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes,
consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at
2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have
been associated with severe limb and genital abnormalities. The exact role of this gene has not been determined.
(provided by RefSeq, Jul 2008)

GeneCards Summary for HOXD9 Gene:
HOXD9 (homeobox D9) is a protein-coding gene. Diseases associated with HOXD9 include brachydactyly-syndactyly syndrome, and developmental dysplasia of hip. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is HOXD11.

UniProtKB/Swiss-Prot: HXD9_HUMAN, P28356
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXD9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the HOXD9 gene promoter:
         E2F-4   E2F-3a   HTF   MIF-1   E2F-2   c-Ets-1   AREB6   E2F   E2F-1   HOXA5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHOXD9 promoter sequence
   Search Chromatin IP Primers for HOXD9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HOXD9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

HOXD9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXD9 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P176987:  view genomic region     (about GC identifiers)

Start:
176,987,088 bp from pter      End:
176,989,853 bp from pter
Size:
2,766 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HXD9_HUMAN, P28356 (See protein sequence)
Recommended Name: Homeobox protein Hox-D9  
Size: 352 amino acids; 36495 Da
Developmental stage: Expressed in the developing limb buds
Caution: It is uncertain whether Met-1 or Met-11 is the initiator
Sequence caution: Sequence=AAH44855.2; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAA42016.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q86ST1

Explore the universe of human proteins at neXtProt for HOXD9: NX_P28356

Explore proteomics data for HOXD9 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HOXD9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055028.3  
    ENSEMBL proteins: 
     ENSP00000249499  

    HOXD9 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HOXL: Homeoboxes / ANTP class : HOXL subclass

    Selected InterPro protein domains (see all 6):
     IPR020479 Homeobox_metazoa
     IPR006711 Hox9_activation_N
     IPR017112 Homeobox_Hox9
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom

    Graphical View of Domain Structure for InterPro Entry P28356

    ProtoNet protein and cluster: P28356

    2 Blocks protein domains:
    IPB000047 Lambda and other repressor helix-turn-helix signature
    IPB006711 Hox9 activation region


    UniProtKB/Swiss-Prot: HXD9_HUMAN, P28356
    Similarity: Belongs to the Abd-B homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    HOXD9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HXD9_HUMAN, P28356
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
    cells with specific positional identities on the anterior-posterior axis

         Genatlas biochemistry entry for HOXD9:
    homeo box D9(4C),homologous to mouse Hox-4.4,Drosophila abd-B

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    HOXD9 for ontologies           About GeneDecksing


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Hoxd9):
     behavior/neurological  cellular  endocrine/exocrine gland  integument  limbs/digits/tail 
     mortality/aging  muscle  nervous system  renal/urinary system  reproductive system 
     skeleton 

    HOXD9 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for HOXD9: Hoxd9tm1Ipc Hoxd9tm1Mrc

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HOXD9
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HOXD9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HOXD9
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HOXD9

    miRNA
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    Block miRNA regulation of human, mouse, rat HOXD9 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HOXD9 (see all 13):
    hsa-miR-582-3p hsa-miR-125a-5p hsa-miR-875-3p hsa-miR-516b hsa-miR-3120-3p hsa-miR-544b hsa-miR-670 hsa-miR-466
    SwitchGear 3'UTR luciferase reporter plasmidHOXD9 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HOXD9
    Predesigned siRNA for gene silencing in human, mouse, rat HOXD9

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXD9

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXD9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HXD9_HUMAN, P28356: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    HOXD9 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including HOXD9: 
              Homeobox (HOX) Genes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HOXD9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HOXD9 (P283563 ENSP000002494994) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MEIS1O004703, ENSP000002723694I2D: score=1 STRING: ENSP00000272369
    PKNOX1P553473, ENSP000002915474I2D: score=1 STRING: ENSP00000291547
    HMGB1P094293, ENSP000003430404I2D: score=2 STRING: ENSP00000343040
    PBX1P404243, ENSP000004058904I2D: score=1 STRING: ENSP00000405890
    PBX3P404263, ENSP000003625884I2D: score=1 STRING: ENSP00000362588
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007519skeletal muscle tissue development IEA--
    GO:0008344adult locomotory behavior IEA--
    GO:0009952anterior/posterior pattern specification IEA--

    HOXD9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HOXD9 (HXD9)

    1 Novoseek inferred chemical compound relationship for HOXD9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 31.9 2 7501971 (2)



    HOXD9 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HOXD9 gene: 
    NM_014213.3  

    Unigene Cluster for HOXD9:

    Homeobox D9
    Hs.236646  [show with all ESTs]
    Unigene Representative Sequence: NM_014213
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000249499(uc010zex.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HOXD9 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HOXD9 (see all 13):
    hsa-miR-582-3p hsa-miR-125a-5p hsa-miR-875-3p hsa-miR-516b hsa-miR-3120-3p hsa-miR-544b hsa-miR-670 hsa-miR-466
    SwitchGear 3'UTR luciferase reporter plasmidHOXD9 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HOXD9
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    GenScript: all cDNA clones in your preferred vector: HOXD9 (NM_014213)
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    Primer
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    OriGene qPCR primer pairs and template standards for HOXD9
    OriGene qSTAR qPCR primer pairs in human, mouse for HOXD9
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HOXD9
      QuantiTect SYBR Green Assays in human, mouse, rat HOXD9
      QuantiFast Probe-based Assays in human, mouse, rat HOXD9

    Additional mRNA sequence: 

    BC044855.1 X59372.1 

    1 DOTS entry:

    DT.412550 

    Selected AceView cDNA sequences (see all 76):

    AI480371 AI394644 AW419056 AI201249 AA938529 AW292591 AW075573 AI306148 
    AI420400 AA886779 BI761261 BG171365 AI972688 AI401822 AI275516 AI127062 
    AI818195 NM_014213 AI239897 BE219356 AI972635 AI694186 AI611280 AI266001 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HOXD9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCTGAAAA
    HOXD9 Expression
    About this image


    HOXD9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Limb (Muscoskeletal System)    fully expand to see all 7 entries
             Progress Zone Cells Limb Bud
             Zeugopod
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Progress Zone Cells Limb Bud
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Progress Zone Cells Limb Bud
     
     Tendon & Ligament
             Lumbar Sclerotome Cells Lumbar Mesenchymal Sclerotome
     
     Mesoderm (Gastrulation Derivatives)
             Limb Bud Mesenchyme Cells Limb Bud
    HOXD9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HOXD9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.236646
        Pathway & Disease-focused RT2 Profiler PCR Array including HOXD9: 
              Homeobox (HOX) Genes in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXD9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HOXD9 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hoxd91 , 5 homeobox D91, 5 86.19(n)1
    84.91(a)1
      2 (44.13 cM)5
    154381  NM_013555.41  NP_038583.11 
     746976805 
    chicken
    (Gallus gallus)
    Aves HOXD91 homeobox D9 74.61(n)
    70.86(a)
      771214  XM_001234506.3  XP_001234507.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    31(a)
    many ↔ many
    GL343356.1(518262-536480)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.215822 Xenopus laevis partial mRNA for homeobox protein (hoxd9 more 82.07(n)    AJ314741.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC056695.12   -- 77.2(n)   30350  BC056695.1 


    ENSEMBL Gene Tree for HOXD9 (if available)
    TreeFam Gene Tree for HOXD9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HOXD9 gene
    HOXD112  ENSG000002571842  HOXD102  HOXC132  HOXC102  HOXD122  HOXA92  HOXA132  
    HOXC92  HOXB132  HOXC122  HOXC112  HOXD132  HOXA112  HOXB92  HOXA102  
    9 SIMAP similar genes for HOXD9 using alignment to 1 protein entry:     HXD9_HUMAN:
    HOX B6    HOXC13    HOXB1    HOXD8    HOXA-9    HOXB9
    HOXA7    HOXC9    HOXC5

    HOXD9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HOXD9 (see all 101)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs796922921,2
    F--176381816(+) AAGCTG/ATGAGC 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1824102501,2
    --176381865(+) GAGTAC/GGGAGA 1 -- us2k10--------
    rs7118201,2
    C,F,A,H--176381981(-) CGGCGC/AGTCCA 1 -- us2k17Minor allele frequency- A:0.42NA CSA EA 249
    rs730337281,2
    C,F--176382036(+) GGGACC/TGAGGG 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs104457651,2
    C,F,H--176382089(+) GATGCG/TGTCGC 1 -- us2k1 ese318Minor allele frequency- T:0.38NS EA NA WA 2340
    rs757709901,2
    C,F--176382303(+) GGCTGC/TAGCCT 1 -- ut511Minor allele frequency- T:0.06WA 118
    rs2002942721,2
    --176382319(+) CTAGTA/CGGTGG 1 -- ut510--------
    rs1446009791,2
    C--176382325(+) GGTGGA/CTCGGG 1 -- ut510--------
    rs1860578721,2
    C--176382385(+) TGCGGC/GACGCC 2 A G mis10--------
    rs2010918241,2
    C--176382663(+) CGTACA/GTTCCC 2 I V mis10--------

    HapMap Linkage Disequilibrium report for HOXD9 (176987088 - 176989853 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for HOXD9:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv875446CNV Loss21882294
    nsv875437CNV Loss21882294
    nsv517968CNV Loss19592680
    nsv875438CNV Loss21882294
    dgv676n67CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HOXD9
    DNA2.0 Custom Variant and Variant Library Synthesis for HOXD9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142982    OMIM disorders: --

    16 diseases for HOXD9:    
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    brachydactyly-syndactyly syndrome    developmental dysplasia of hip    brachydactyly    syndactyly
    clubfoot    hirschsprung's disease    arthropathy    esophageal squamous cell carcinoma
    rheumatoid arthritis    neuroblastoma    arthritis    esophagitis
    squamous cell carcinoma    neuronitis    leukemia    prostatitis

    1 disease from the University of Copenhagen DISEASES database for HOXD9:
    Leukemia

    HOXD9 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for HOXD9 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rheumatoid arthritis 19.6 3 11352232 (1), 10211882 (1)

    Genetic Association Database (GAD): HOXD9
    Human Genome Epidemiology (HuGE) Navigator: HOXD9 (3 documents)

    Export disorders for HOXD9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HOXD9 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with HOXD9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. HOX4 genes encode transcription factors with potential auto- and cross-regulatory capacities. (PubMed id 1756725)1, 2, 9 Zappavigna V.... Duboule D. (EMBO J. 1991)
    2. Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six Loci influencing serum magnesium levels. (PubMed id 20700443)1, 4 Meyer T.E.... . (PLoS Genet. 2010)
    3. Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot. (PubMed id 19938081)1, 4 Ester A.R....Hecht J.T. (Am. J. Med. Genet. A 2009)
    4. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    5. Complete mutation analysis panel of the 39 human HOX genes. (PubMed id 11857506)1, 2 Kosaki K.... Matsuo N. (Teratology 2002)
    6. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (Cell 1992)
    7. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (Genomics 1990)
    8. The human HOX gene family. (PubMed id 2574852)1, 2 Acampora D.... Boncinelli E. (Nucleic Acids Res. 1989)
    9. Complementary homeo protein gradients in developing limb buds. (PubMed id 2568311)1, 2 Oliver G.... De Robertis E.M. (Genes Dev. 1989)
    10. Immunocytochemical detection of HoxD9 and Pbx1 homeodomain protein expression in Chinese esophageal squamous cell carcinomas. (PubMed id 15770739)1, 9 Liu D.B....Li J.Y. (World J. Gastroenterol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3235 HGNC: 5140 AceView: HOXD9 Ensembl:ENSG00000128709 euGenes: HUgn3235
    ECgene: HOXD9 H-InvDB: HOXD9

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HOXD9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HOXD9 gene:
    Search GeneIP for patents involving HOXD9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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