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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HOXD9 Gene

protein-coding   GIFtS: 51
GCID: GC02P176987

homeobox D9

(Previous name: homeo box D9 )
(Previous symbols: HOX4C, HOX4)
 Explore 15 diseases affiliated with
HOXD9 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HOXD9    

Aliases
for HOXD9 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Homeobox D91 2     Homeobox Protein Hox-5.22 3
HOX4C1 2 3 5     Hox-4.32
HOX41 2     Hox-5.22
Homeo Box D91 2     Homeobox Protein Hox-D92
Homeobox Protein Hox-4C2 3     Hox-4.3, Mouse, Homolog Of2

External Ids:    HGNC: 51401   Entrez Gene: 32352   Ensembl: ENSG000001287097   OMIM: 1429825   UniProtKB: P283563   

Export aliases for HOXD9 gene to outside databases

Previous GC identifers: GC02P175040 GC02P175648 GC02P176951 GC02P177189 GC02P176812 GC02P176695 GC02P168864


Summaries
for HOXD9 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HOXD9:
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription
factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar
homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes
arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions
that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital
abnormalities. The exact role of this gene has not been determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HXD9_HUMAN, P28356
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXD9


Genomic Views
for HOXD9 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HOXD9 gene promoter:
         E2F-4   E2F-3a   HTF   MIF-1   E2F-2   c-Ets-1   AREB6   E2F   E2F-1   HOXA5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HOXD9 promoter sequence
   Search SABiosciences Chromatin IP Primers for HOXD9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOXD9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

HOXD9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXD9 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P176987:  view genomic region     (about GC identifiers)

Start:
 176,987,088 bp from pter      End:
 176,989,853 bp from pter
Size:
 2,766 bases      Orientation:
 plus strand

Proteins
for HOXD9 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HXD9_HUMAN, P28356 (See protein sequence)
Recommended Name: Homeobox protein Hox-D9  
Size: 352 amino acids; 36495 Da
Subcellular location: Nucleus
Developmental stage: Expressed in the developing limb buds
Caution: It is uncertain whether Met-1 or Met-11 is the initiator
Sequence caution: Sequence=AAH44855.2; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAA42016.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q86ST1

Explore the universe of human proteins at neXtProt for HOXD9: NX_P28356

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P28356

    • HOXD9 Protein expression data from MOPED and PaxDb:    About this image 
    HOXD9 Protein Expression
    REFSEQ proteins: NP_055028.3  
    ENSEMBL proteins: 
     ENSP00000249499  

    Human Recombinant Protein Products for HOXD9: 
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    OriGene Custom Protein Services for HOXD9 
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    Novus Biologicals HOXD9 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HOXD9

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    HOXD9 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for HOXD9

    Protein Domains /
    Families
    for HOXD9 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HOXD9 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR020479 Homeobox_metazoa
     IPR006711 Hox9_activation_N
     IPR017112 Homeobox_Hox9
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain

    Graphical View of Domain Structure for InterPro Entry P28356

    ProtoNet protein and cluster: P28356

    2 Blocks protein families:
    IPB000047 Lambda and other repressor helix-turn-helix signature
    IPB006711 Hox9 activation region


    UniProtKB/Swiss-Prot: HXD9_HUMAN, P28356
    Similarity: Belongs to the Abd-B homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for HOXD9 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HXD9_HUMAN, P28356
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
    with specific positional identities on the anterior-posterior axis

         Genatlas biochemistry entry for HOXD9:
    homeo box D9(4C),homologous to mouse Hox-4.4,Drosophila abd-B

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    HOXD9 for ontologies           About GeneDecksing


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Hoxd9):
     behavior/neurological  cellular  endocrine/exocrine gland  integument  limbs/digits/tail 
     mortality/aging  muscle  nervous system  renal/urinary system  reproductive system 
     skeleton 

    HOXD9 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for HOXD9: Hoxd9tm1Ipc Hoxd9tm1Mrc
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HOXD9 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXD9
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXD9 (see all 13):
    hsa-miR-582-3p hsa-miR-125a-5p hsa-miR-875-3p hsa-miR-516b hsa-miR-3120-3p hsa-miR-544b hsa-miR-670 hsa-miR-466
    SwitchGear 3'UTR luciferase reporter plasmid: HOXD9 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXD9 (see all 4)
    OriGene shRNA RFP: HOXD9
    OriGene siRNA: HOXD9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXD9
    Sirion Biotech Custom design and validation of potent shRNA sequences against HOXD9 

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of HOXD9 
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXD9


    Pathways & Interactions
    for HOXD9 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HOXD9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/12 Interacting proteins for HOXD9 (P283563 ENSP000002494994) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MEIS1O004703, ENSP000002723694I2D: score=1 STRING: ENSP00000272369
    PKNOX1P553473, ENSP000002915474I2D: score=1 STRING: ENSP00000291547
    HMGB1P094293, ENSP000003430404I2D: score=2 STRING: ENSP00000343040
    PBX1P404243, ENSP000004058904I2D: score=1 STRING: ENSP00000405890
    FAIM3O606673, ENSP000003560584I2D: score=1 STRING: ENSP00000356058
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0007519skeletal muscle tissue development IEA--
    GO:0008344adult locomotory behavior IEA--
    GO:0009952anterior/posterior pattern specification IEA--
    GO:0009954proximal/distal pattern formation IEA--

    HOXD9 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HOXD9 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HOXD9 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HOXD9
    1 Novoseek chemical compound relationship for HOXD9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 31.9 2 7501971 (2)

    Search CenterWatch for drugs/clinical trials and news about HOXD9 / HXD9 

    Transcripts
    for HOXD9 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HOXD9 gene: 
    NM_014213.3  

    Unigene Cluster for HOXD9:

    Homeobox D9
    Hs.236646  [show with all ESTs]
    Unigene Representative Sequence: NM_014213
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000249499(uc010zex.2) ENST00000553241

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXD9
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXD9 (see all 13):
    hsa-miR-582-3p hsa-miR-125a-5p hsa-miR-875-3p hsa-miR-516b hsa-miR-3120-3p hsa-miR-544b hsa-miR-670 hsa-miR-466
    SwitchGear 3'UTR luciferase reporter plasmid: HOXD9 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXD9 (see all 4)
    OriGene shRNA RFP: HOXD9
    OriGene siRNA: HOXD9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXD9
    Sirion Biotech Custom design and validation of potent shRNA sequences against HOXD9 
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HOXD9 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HOXD9 (NM_014213)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXD9
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXD9

    Additional cDNA sequence: 

    BC044855.1 X59372.1 

    1 DOTS entry:

    DT.412550 

    24/76 AceView cDNA sequences (see all 76):

    AI127062 AA886779 AI239897 BG171365 AW292591 AI201249 AI972635 AW419056 
    AA938529 AI420400 AI401822 AI972688 BE219356 BI761261 AI394644 AI480371 
    AI275516 AI306148 AW075573 NM_014213 AI818195 BX104609 AI367299 AI266001 

    GeneLoc Exon Structure


    Expression
    for HOXD9 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HOXD9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTCTGAAAA
    HOXD9 Expression
    About this image

    HOXD9 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    10/12 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 12) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbLimb BudLimb Bud Mesenchyme CellsMesoderm
    LimbLimb BudProgress Zone CellsBone, Cartilage
    SomiteLumbar Mesenchymal SclerotomeLumbar Sclerotome CellsBone, Cartilage, Tendons & Ligaments
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    LimbZeugopodPrechondrocytic Mesenchymal CellsBone, Cartilage
    Neural TubeNeural TubeSpinal Neural Tube CellsNeural Ectoderm
    Gut TubeMidgutGut Tube
    KidneyMetanephrosKidney
    LimbAutopodLimb
    LimbStylopodLimb
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HOXD9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HOXD9

    SOURCE GeneReport for Unigene cluster: Hs.236646
        SABiosciences Expression via Pathway-Focused PCR Array including HOXD9: 
              Homeobox (HOX) Genes in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for HOXD9 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for HOXD9 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves HOXD91 homeobox D9 76.03(n)
    74.58(a)    		   771214  XM_001234506.2  XP_001234507.2 
    lizard
    (Anolis carolinensis)    		 Reptilia HOXD96
    		 --
    		 26(a)
    		 possible ortholog
    		 GL343356.1(518262-536480)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.215822 Xenopus laevis partial mRNA for homeobox protein (hoxd9 more 82.07(n)    AJ314741.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BC056695.12   -- 77.2(n)   30350  BC056695.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea nob-16
    		 kNOB-like posterior (NO Backside) family member (n...
    		 16(a)
    		 1 → many
    		 III(12077688-12084220)


    ENSEMBL Gene Tree for HOXD9 (if available)
    TreeFam Gene Tree for HOXD9 (if available) 

    Paralogs
    for HOXD9 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HOXD9 gene
    HOXA92  HOXA132  HOXC92  HOXD112  HOXC122  ENSG000002571842  HOXB132  HOXD102  
    HOXC112  HOXA112  HOXD132  HOXC132  HOXB92  HOXC102  HOXD122  HOXA102  
    10 SIMAP similar genes for HOXD9 using alignment to 1 protein entry:     HXD9_HUMAN:
    HOX B6    HOXC13    HOXB1    HOXD8    HOXA-9    HOXB9
    HOXA7    HOXC9    HOXC5    HOXA9

    HOXD9 for paralogs           About GeneDecksing



    Genomic Variants
    for HOXD9 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/65 NCBI SNPs in HOXD9 are shown (see all 65)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1919080361,2
    		--176985634(+) ATCTAA/GTCCTG 1 -- us2k10--------
    rs7118191,2
    		C,F,A,H--176985696(-) ACCTCG/AGGTAA 1 -- us2k125Minor allele frequency- A:0.25NS EA NA WA CSA 2354
    rs1496905741,2
    		--176985720(+) TCAAAG/TAGCTT 1 -- us2k10--------
    rs1814872251,2
    		--176985772(+) TAAATA/GTTTCC 1 -- us2k10--------
    rs787497691,2
    		F--176985900(+) TAGGGG/CGCCAT 1 -- us2k11Minor allele frequency- C:0.07WA 118
    rs1864992421,2
    		--176985917(+) GGGGTA/GGGGGA 1 -- us2k10--------
    rs133853111,2
    		C--176985920(+) GTGGGA/C/GGAGAG 1 -- us2k1 trp30--------
    rs1112779411,2
    		C--176986262(+) CTGCCG/TGCGCC 1 -- us2k12Minor allele frequency- T:0.04WA 120
    rs37317941,2
    		C,H--176986429(+) TCGGCC/AGAATT 1 -- us2k14Minor allele frequency- A:0.00NS EA 418
    rs116754081,2
    		H--176986526(+) GCTGAA/GGCGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HOXD9 (176987088 - 176989853 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HOXD9: --

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    Disorders / Diseases
    for HOXD9 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HOXD9 for disorders           About GeneDecksing

    OMIM gene information: 142982    OMIM disorders: --

    15 diseases for HOXD9:    About MalaCards
    brachydactyly-syndactyly syndrome    syndactyly    synpolydactyly    esophageal squamous cell carcinoma
    brachydactyly    squamous cell carcinoma    rheumatoid arthritis    hirschsprung's disease
    clubfoot    arthropathy    arthritis    esophagitis
    carcinoma    neuroblastoma    neuronitis

    1 disease from the University of Copenhagen DISEASES database for HOXD9:
    Leukemia

    1 Novoseek disease relationship for HOXD9 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rheumatoid arthritis 19.6 3 11352232 (1), 10211882 (1)

    Human Genome Epidemiology (HuGE) Navigator: HOXD9 (3 documents)

    Export disorders for HOXD9 gene to outside databases

    Publications
    for HOXD9 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HOXD9 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with HOXD9)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. HOX4 genes encode transcription factors with potential auto- and cross-regulatory capacities. (PubMed id 1756725)1, 2, 9 Zappavigna V.... Duboule D. (1991)
    2. Complete mutation analysis panel of the 39 human HOX genes. (PubMed id 11857506)1, 2 Kosaki K.... Matsuo N. (2002)
    3. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (1992)
    4. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (1990)
    5. The human HOX gene family. (PubMed id 2574852)1, 2 Acampora D.... Boncinelli E. (1989)
    6. Complementary homeo protein gradients in developing limb buds. (PubMed id 2568311)1, 2 Oliver G.... De Robertis E.M. (1989)
    7. Immunocytochemical detection of HoxD9 and Pbx1 homeodomain protein expression in Chinese esophageal squamous cell carcinomas. (PubMed id 15770739)1, 9 Liu D.B....Li J.Y. (2005)
    8. HMG1 interacts with HOX proteins and enhances their DNA binding and transcriptional activation. (PubMed id 8890171)1, 9 Zappavigna V....Bianchi M.E. (1996)
    9. PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins. (PubMed id 10523646)1, 9 Shanmugam K....Featherstone M.S. (1999)
    10. Specificity of HOX protein function depends on DNA-protein and protein-protein interactions, both mediated by the homeo domain. (PubMed id 7926763)1, 9 Zappavigna V....Mavilio F. (1994)

    External Searches for HOXD9 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HOXD9 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3235 HGNC: 5140 AceView: HOXD9 Ensembl:ENSG00000128709 euGenes: HUgn3235
    ECgene: HOXD9 H-InvDB: HOXD9

    Other Databases showing HOXD9 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HOXD9 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HOXD9 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HOXD9 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HOXD9 gene:
    Search GeneIP for patents involving HOXD9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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