Aliases for HOXD8 Gene
Aliases for HOXD8 Gene
External Ids for HOXD8 Gene
- HGNC: 5139
- Entrez Gene: 3234
- Ensembl: ENSG00000175879
- OMIM: 142985
- UniProtKB: P13378
Previous HGNC Symbols for HOXD8 Gene
- HOX4
- HOX4E
Previous GeneCards Identifiers for HOXD8 Gene
- GC02P175047
- GC02P175655
- GC02P176958
- GC02P177197
- GC02P177195
- GC02P176819
- GC02P176702
- GC02P168871
- GC02P176994
Summaries for HOXD8 Gene
-
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
GeneCards Summary for HOXD8 Gene
HOXD8 (Homeobox D8) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is HOXC8.
UniProtKB/Swiss-Prot for HOXD8 Gene
-
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXD8 Gene
Genomics for HOXD8 Gene
Regulatory Elements for HOXD8 Gene
Enhancers for HOXD8 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HOXD8 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for HOXD8 Gene
- Chromosome:
- 2
- Start:
- 176,129,694 bp from pter
- End:
- 176,132,695 bp from pter
- Size:
- 3,002 bases
- Orientation:
- Plus strand
Genomic View for HOXD8 Gene
Genes around HOXD8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q31.1 by Ensembl
- 2q31.1 by Entrez Gene
- 2q31.1 by HGNC
HOXD8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HOXD8 Gene
Proteins for HOXD8 Gene
-
Protein details for HOXD8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P13378-HXD8_HUMAN
- Recommended name:
- Homeobox protein Hox-D8
- Protein Accession:
- P13378
- F8WBG7
- Q5BL00
- Q8IXZ1
Protein attributes for HOXD8 Gene
- Size:
- 290 amino acids
- Molecular mass:
- 31911 Da
- Quaternary structure:
- No Data Available
Protein Expression for HOXD8 Gene
Post-translational modifications for HOXD8 Gene
Other Protein References for HOXD8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HOXD8
-
Abcam antibodies for HOXD8
- Invitrogen Antibodies for HOXD8
- antibodies-online Antibodies for HOXD8: See all 47
- GeneTex HOXD8 antibody for HOXD8
-
Santa Cruz Biotechnology (SCBT) Antibodies for HOXD8
Protein Products
-
OriGene Purified Proteins for HOXD8
- Search Origene for MassSpec and Protein Over-expression Lysates for HOXD8
- Origene Custom Protein Services for HOXD8
- antibodies-online Proteins for HOXD8: See all 9
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HOXD8
-
Abcam proteins for HOXD8
Assay Products
- antibodies-online Kits for HOXD8: See all 2
No data available for DME Specific Peptides for HOXD8 Gene
Domains & Families for HOXD8 Gene
Gene Families for HOXD8 Gene
Protein Domains for HOXD8 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HOXD8 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P13378- Family:
-
- Belongs to the Antp homeobox family.
Function for HOXD8 Gene
Molecular function for HOXD8 Gene
- GENATLAS Biochemistry:
- homeo box D8(4E),homologous to mouse Hox-4.3,Drosophila antp,Ubx,abd-A
- UniProtKB/Swiss-Prot Function:
- Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 1756725 |
| GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | IDA | 1756725 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | IEA | -- |
| GO:0043565 | sequence-specific DNA binding | IEA | -- |
Phenotypes for HOXD8 Gene
- MGI mutant phenotypes for HOXD8:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HOXD8:
Animal Models for HOXD8 Gene
- MGI Knock Outs for HOXD8:
-
- Hoxd8 tm1Jdes
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXD8 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXD8 gene
- Search ViGene Biosciences for HOXD8
CRISPR Products
-
OriGene CRISPR knockouts for HOXD8
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXD8
- GenScript: Design CRISPR guide RNA sequences for HOXD8
miRNA for HOXD8 Gene
- miRTarBase miRNAs that target HOXD8
miRNA Products
- Search ViGene Biosciences for HOXD8
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HOXD8
- Browse OriGene Inhibitory RNA Products For HOXD8
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXD8 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HOXD8
Cell Line Products
-
Horizon Cell Lines for HOXD8
-
ViGene Biosciences adenoviral particle packaged cDNA for HOXD8 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXD8 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXD8 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXD8 Gene
Localization for HOXD8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HOXD8 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | NAS | 2568311 |
Pathways & Interactions for HOXD8 Gene
No Data Available
Interacting Proteins for HOXD8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006366 | transcription from RNA polymerase II promoter | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for HOXD8 Gene
Transcripts for HOXD8 Gene
mRNA/cDNA for HOXD8 Gene
- (3) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (36) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HOXD8
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXD8
- GenScript: Design CRISPR guide RNA sequences for HOXD8
miRNA Products
- Search ViGene Biosciences for HOXD8
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HOXD8
- Browse OriGene Inhibitory RNA Products For HOXD8
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXD8 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HOXD8
Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b |
|---|---|---|---|---|---|
| SP1: | |||||
| SP2: |
Expression for HOXD8 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Somite (Muscoskeletal System)
- Sclerotome Cells Thoracic Mesenchymal Sclerotome
- Thoracic Mesenchymal Sclerotome
- Sacral Mesenchymal Sclerotome
- Lumbar Mesenchymal Sclerotome
-
Bone (Muscoskeletal System)
- Prechondrocytic Mesenchymal Cells Vertebral Body
- Osteochondro Mesenchymal Cells Vertebrae
- Sclerotome Cells Thoracic Mesenchymal Sclerotome
-
Cartilage (Muscoskeletal System)
- Prechondrocytic Mesenchymal Cells Vertebral Body
- Osteochondro Mesenchymal Cells Vertebrae
- Sclerotome Cells Thoracic Mesenchymal Sclerotome
-
Hair (Integumentary System)
- Bulge Stem Cells Bulge
-
Testis (Reproductive System)
- Testicular Interstitial Cells Testis Interstitium
-
Tendon amp Ligament
- Sclerotome Cells Thoracic Mesenchymal Sclerotome
- Head Mesenchyme (Muscoskeletal System)
- Kidney (Urinary System)
-
Skeletal Muscle (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for HOXD8 Gene
This gene is overexpressed in Kidney - Cortex (x8.0).
This gene is overexpressed in Testis (49.1), Fetal testis (11.2), and Platelet (8.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HOXD8 Gene
NURSA nuclear receptor signaling pathways regulating expression of HOXD8 Gene:
HOXD8SOURCE GeneReport for Unigene cluster for HOXD8 Gene:
Hs.301963Evidence on tissue expression from TISSUES for HOXD8 Gene
- Kidney(4.3)
- Nervous system(4.1)
Primer Products
-
OriGene qPCR primer pairs for HOXD8
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXD8 Gene
Orthologs for HOXD8 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HOXD8 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HOXD8 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HOXD8 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Hoxd8 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | HOXD8 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | HOXD8 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HOXD8 34 35 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hoxd8 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC68588 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Ubx 35 |
|
ManyToMany | |
| abd-A 35 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | mab-5 35 |
|
ManyToMany | |
| lin-39 35 |
|
ManyToMany |
- Species where no ortholog for HOXD8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- zebrafish (Danio rerio)
Paralogs for HOXD8 Gene
Paralogs for HOXD8 Gene
(24) SIMAP similar genes for HOXD8 Gene using alignment to 2 proteins:
Variants for HOXD8 Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1001383013 | -- | 176,130,269(+) | CAGCC(C/G)CCCCA | intron-variant, upstream-variant-2KB, utr-variant-5-prime | |
| rs1001595837 | -- | 176,132,415(+) | ATCGC(A/C)TGAAA | utr-variant-3-prime | |
| rs1002199988 | -- | 176,130,834(+) | GAGCT(A/G)GTACA | upstream-variant-2KB, reference, synonymous-codon, utr-variant-5-prime | |
| rs1002420999 | -- | 176,129,922(+) | GAGTG(A/T)CCCCG | intron-variant, upstream-variant-2KB, utr-variant-5-prime | |
| rs1003391653 | -- | 176,132,997(+) | TTACA(C/G)CACAG | downstream-variant-500B |
Residual Variation Intolerance Score:
72.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.34;
63.20% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HOXD8 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HOXD8
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXD8 Gene
Disorders for HOXD8 Gene
Relevant External Links for HOXD8
No disorders were found for HOXD8 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOXD8 Gene
Publications for HOXD8 Gene
- High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 46 64
- Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot. (PMID: 19938081) Ester A.R. … Hecht J.T. (Am. J. Med. Genet. A 2009) 3 46 64
- Complete mutation analysis panel of the 39 human HOX genes. (PMID: 11857506) Kosaki K. … Matsuo N. (Teratology 2002) 3 4 64
- Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott M.P. (Cell 1992) 2 3 64
- Nomenclature for human homeobox genes. (PMID: 1973146) McAlpine P.J. … Shows T.B. (Genomics 1990) 2 3 64
Products for HOXD8 Gene
- Browse R&D Systems for Antibodies
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- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
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- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HOXD8
- Search Origene for MassSpec and Protein Over-expression Lysates for HOXD8
- Origene Custom Protein Services for HOXD8
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HOXD8
- Browse OriGene Inhibitory RNA Products For HOXD8
- OriGene qPCR primer pairs for HOXD8
- OriGene CRISPR knockouts for HOXD8
- OriGene ORF clones in human for HOXD8
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for HOXD8 in any vector
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- GenScript Custom Assay Services for HOXD8
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- GenScript: Design CRISPR guide RNA sequences for HOXD8
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- CloneReady with Over 120,000 Genes
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- Novus Biologicals Antibodies for HOXD8
- Novus Biologicals proteins and lysates for HOXD8
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for HOXD8
- Abcam proteins for HOXD8
- Search for Assays for HOXD8 at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Addgene plasmids for HOXD8
- antibodies-online Antibodies for HOXD8: See all 47
- antibodies-online Kits for HOXD8: See all 2
- antibodies-online Proteins for HOXD8: See all 9
- Search antibodies-online for peptides
- GeneTex HOXD8 antibody for HOXD8
- Search GeneTex for Proteins for HOXD8
- ViGene Biosciences adenoviral particle packaged cDNA for HOXD8 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HOXD8 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HOXD8 gene
- Search ViGene Biosciences for HOXD8
- Santa Cruz Biotechnology (SCBT) Antibodies for HOXD8
- Search Santa Cruz Biotechnology (SCBT) for HOXD8 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HOXD8
- Horizon Cell Lines for HOXD8
- Cyagen custom Knockout/knockin (KOKI) mouse models for HOXD8
- VectorBuilder custom plasmid, inducible vectors for HOXD8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HOXD8
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HOXD8 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
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- (135) Gene Damage Index
- (136) ViGene Biosciences
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- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer