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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HOXD8 Gene

protein-coding   GIFtS: 53
GCID: GC02P176994

homeobox D8

(Previous name: homeo box D8 )
(Previous symbols: HOX4, HOX4E)
 Explore 4 diseases affiliated with
HOXD8 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HOXD8    

Aliases
for HOXD8 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Homeobox D81 2     HOX5.42
HOX4E1 2 3 5     Hox-4.52
HOX41 2     Homeo Box 4E2
Homeo Box D81 2     Homeobox Protein 5.42
Homeobox Protein Hox-4E2 3     Homeobox Protein Hox-D82
Homeobox Protein Hox-5.42 3     

External Ids:    HGNC: 51391   Entrez Gene: 32342   Ensembl: ENSG000001758797   OMIM: 1429855   UniProtKB: P133783   

Export aliases for HOXD8 gene to outside databases

Previous GC identifers: GC02P175047 GC02P175655 GC02P176958 GC02P177197 GC02P177195 GC02P176819 GC02P176702 GC02P168871


Summaries
for HOXD8 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HOXD8:
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription
factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar
homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes
arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions
that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and
genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult
urogenital tract function. Alternate splicing results in multiple transcript variants.(provided by RefSeq, Dec 2010)

UniProtKB/Swiss-Prot: HXD8_HUMAN, P13378
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXD8


Genomic Views
for HOXD8 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HOXD8 gene promoter:
         E2F-3a   E2F-4   E2F-5   HTF   Nkx2-5   E2F-2   E2F   E2F-1   HOXA5   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for HOXD8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOXD8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

HOXD8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXD8 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P176994:  view genomic region     (about GC identifiers)

Start:
 176,994,422 bp from pter      End:
 176,997,423 bp from pter
Size:
 3,002 bases      Orientation:
 plus strand

Proteins
for HOXD8 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HXD8_HUMAN, P13378 (See protein sequence)
Recommended Name: Homeobox protein Hox-D8  
Size: 290 amino acids; 31911 Da
Subcellular location: Nucleus
Secondary accessions: F8WBG7 Q5BL00 Q8IXZ1
Alternative splicing: 3 isoforms:  P13378-1   P13378-2   P13378-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HOXD8: NX_P13378

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P13378

    • HOXD8 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001186675.1  NP_001186676.1  NP_062458.1  

    ENSEMBL proteins: 
     ENSP00000406045   ENSP00000315949   ENSP00000448196   ENSP00000409026   ENSP00000437431  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: HOXD8
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    Novus Biologicals HOXD8 Proteins
    Novus Biologicals HOXD8 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HOXD8

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS2568311


    HOXD8 for ontologies           About GeneDecksing



    HOXD8 Antibody Products: 
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    Uscn Antibodies for HOXD8
    ThermoFisher Antibodies for HOXD8

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    Uscn ELISAs and CLIAs for HOXD8

    Protein Domains /
    Families
    for HOXD8 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HOXD8 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR001827 Homeobox_Antennapedia_CS
     IPR020479 Homeobox_metazoa
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P13378

    ProtoNet protein and cluster: P13378

    1 Blocks protein family: IPB001827 Homeobox protein

    UniProtKB/Swiss-Prot: HXD8_HUMAN, P13378
    Similarity: Belongs to the Antp homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for HOXD8 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HXD8_HUMAN, P13378
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
    with specific positional identities on the anterior-posterior axis

         Genatlas biochemistry entry for HOXD8:
    homeo box D8(4E),homologous to mouse Hox-4.3,Drosophila antp,Ubx,abd-A

    miRNA
    Products:            		miRTarBase miRNAs that target HOXD8:
    hsa-mir-196a (MIRT002941)

    OriGene 3'-UTR Clone: HOXD8
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXD8
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXD8:
    hsa-miR-3671 hsa-miR-142-5p hsa-miR-4325 hsa-miR-519c-3p hsa-miR-519a hsa-miR-519b-3p hsa-miR-335
    SwitchGear 3'UTR luciferase reporter plasmid: HOXD8 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXD8 (see all 4)
    OriGene shRNA RFP: HOXD8
    OriGene siRNA: HOXD8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXD8

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HOXD8

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HOXD8 (see all 2)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): HOXD8 (NM_001199747)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXD8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXD8 

    Cell Line
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    Search LifeMap BioReagents cell lines for HOXD8

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXD8

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity NAS--
    GO:0043565sequence-specific DNA binding IEA--


    HOXD8 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Hoxd8tm1Jdes for HOXD8
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Hoxd8):
     skeleton 

    HOXD8 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HOXD8 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HOXD8

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/6 Interacting proteins for HOXD8 (P133782, 3 ENSP000003159494) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANXA7P200732, 3MINT-8248461 I2D: score=2 
    CDKN1AP389362, 3MINT-8251970 I2D: score=2 
    PFDN1O609252, 3MINT-8265875 I2D: score=2 
    RCC1P187542, 3MINT-8268416 I2D: score=2 
    HMGB1P094293, ENSP000003430404I2D: score=1 STRING: ENSP00000343040
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS--
    GO:0007275multicellular organismal development ----
    GO:0008595anterior/posterior axis specification, embryo NAS2568311


    HOXD8 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HOXD8 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HOXD8
    Search CenterWatch for drugs/clinical trials and news about HOXD8 / HXD8 

    Transcripts
    for HOXD8 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HOXD8 gene (3 alternative transcripts): 
    NM_001199746.1  NM_001199747.1  NM_019558.3  

    Unigene Cluster for HOXD8:

    Homeobox D8
    Hs.301963  [show with all ESTs]
    Unigene Representative Sequence: NM_019558
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000429017 ENST00000313173(uc002ukn.3 uc002ukp.3 uc002uko.3)
    ENST00000548663 ENST00000450510 ENST00000544999

    miRNA
    Products:             		 OriGene 3'-UTR Clone: HOXD8
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXD8
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXD8:
    hsa-miR-3671 hsa-miR-142-5p hsa-miR-4325 hsa-miR-519c-3p hsa-miR-519a hsa-miR-519b-3p hsa-miR-335
    SwitchGear 3'UTR luciferase reporter plasmid: HOXD8 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXD8 (see all 4)
    OriGene shRNA RFP: HOXD8
    OriGene siRNA: HOXD8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXD8
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): HOXD8 (NM_001199747)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXD8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXD8 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HOXD8
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HOXD8
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXD8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXD8

    Additional cDNA sequence: 

    BC038709.1 BC090853.1 

    4 DOTS entries:

    DT.86849849  DT.91650475  DT.106454  DT.120935760 

    24/36 AceView cDNA sequences (see all 36):

    CR613626 AW140108 CR613054 NM_019558 AI521778 BC038709 AA905044 AI093486 
    BQ429720 BI764317 T29810 BF057634 AL520835 W81629 AL520834 AI300186 
    AI129333 BX097161 AL530925 AI936395 BG432602 AI623322 AI222194 AW197515 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for HOXD8    About this scheme

    ExUns: 1 ^ 2a · 2b
    SP1:                  
    SP2:                  


    ECgene alternative splicing isoforms for HOXD8

    Expression
    for HOXD8 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HOXD8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCACTGCTCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HOXD8 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    SomiteThoracic Mesenchymal SclerotomeThoracic Sclerotome CellsBone, Cartilage, Tendons & Ligaments
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HOXD8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HOXD8

    SOURCE GeneReport for Unigene cluster: Hs.301963
        SABiosciences Expression via Pathway-Focused PCR Array including HOXD8: 
              Homeobox (HOX) Genes in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXD8

    Orthologs
    for HOXD8 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for HOXD8 gene from 4/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves HOXD81 homeobox D8 81.85(n)
    82.63(a)    		   396301  NM_207177.1  NP_997060.1 
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC685882 hypothetical protein MGC68588 79.39(n)    BC060408.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta zen26
    Ubx6
    (see all 4)    		 Ultrabithorax
    (see all 4)    		 19(a)
    17(a)
    (see all 4)    		 possible ortholog
    many ↔ many
    (see all 4)    		 3R(2568854-2569862)
    3R(12482345-12560348)
    worm
    (Caenorhabditis elegans)    		 Secernentea lin-396
    egl-56
    		 Homeobox protein egl-5
    		 21(a)
    18(a)
    		 possible ortholog
    1 ↔ many
    		 III(7528603-7536567)
    III(7814317-7816386)


    ENSEMBL Gene Tree for HOXD8 (if available)
    TreeFam Gene Tree for HOXD8 (if available) 

    Paralogs
    for HOXD8 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HOXD8 gene
    GSX12  HOXA72  HOXA12  HOXD12  HOXA22  HOXB32  HOXC62  HOXB52  
    GSX22  HOXC52  HOXB42  HOXA52  HOXA42  HOXD32  HOXC82  HOXA62  
    HOXA32  HOXB12  HOXB62  HOXB82  HOXD42  HOXB22  HOXB72  PDX12  
    HOXC42  
    18/27 SIMAP similar genes for HOXD8 using alignment to 2 protein entries:     HXD8_HUMAN (see all proteins) (see all similar genes):
    HOXA4    HOXB3    HOXA3    HOXC4    HOXB8    HOXC8
    HHEX    NKX6-1    HOXB5    HOXD9    HOXA10    HOXB7
    HOXA6    HOXA-9    HOXC5    HLX    HOXC6    HOXD3

    HOXD8 for paralogs           About GeneDecksing



    Genomic Variants
    for HOXD8 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/91 NCBI SNPs in HOXD8 are shown (see all 91)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1475707711,2
    		--176992442(+) CATTT-/CTCCCC 1 -- us2k10--------
    rs680035241,2
    		C,F,--176992443(+) CATTTC/TCCCCC 1 -- us2k12Minor allele frequency- T:0.50NA CSA 4
    rs8471641,2
    		C,F,A,H,--176992444(-) GGGGGA/GAAAAT 1 -- us2k1 tfbs3 trp35Minor allele frequency- G:0.22WA NA CSA 9
    rs1504668541,2
    		C,--176992491(+) TTCAA-/ACA   
       CACAC    ACACA     		3 -- us2k10--------
    rs283675321,2
    		C,--176992527(+) ACACAG/CGCCAA 3 -- us2k1 tfbs31Minor allele frequency- C:0.00NA 2
    rs1496478941,2
    		C,--176992527(+) CACAC-/ACAC  
      ACACAG    GCCAA     		3 -- us2k10--------
    rs1870014251,2
    		--176992539(+) CTGAAA/GAAAAG 3 -- us2k10--------
    rs1910761311,2
    		--176992653(+) TCGTTC/TGCCTT 3 -- us2k10--------
    rs1824383791,2
    		--176992708(+) AAAAAA/CCCCAC 3 -- us2k10--------
    rs1438359691,2
    		--176992753(+) GCTCTC/TCACCA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for HOXD8 (176994422 - 176997423 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HOXD8: --

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    Disorders / Diseases
    for HOXD8 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HOXD8 for disorders           About GeneDecksing

    OMIM gene information: 142985    OMIM disorders: --

    4 diseases for HOXD8:    About MalaCards
    clubfoot    neuroblastoma    thyroiditis    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: HOXD8 (3 documents)

    Export disorders for HOXD8 gene to outside databases

    Publications
    for HOXD8 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HOXD8 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with HOXD8)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete mutation analysis panel of the 39 human HOX genes. (PubMed id 11857506)1, 2 Kosaki K.... Matsuo N. (2002)
    2. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (1992)
    3. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (1990)
    4. Complementary homeo protein gradients in developing limb buds. (PubMed id 2568311)1, 2 Oliver G.... De Robertis E.M. (1989)
    5. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    6. Altered transmission of HOX and apoptotic SNPs identi fy a potential common pathway for clubfoot. (PubMed id 19938081)1 Ester A.R....Hecht J.T. (2009)
    7. Identification of targets of Prox1 during in vitro va scular differentiation from embryonic stem cells: functional roles of HoxD8 in lymphangiogenesis. (PubMed id 19825936)1 Harada K....Miyazono K. (2009)
    8. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1 Yerges L.M....Zmuda J.M. (2009)
    9. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    External Searches for HOXD8 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    NCBI Bookshelf
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    Genome Databases showing HOXD8 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3234 HGNC: 5139 AceView: HOXD8 Ensembl:ENSG00000175879 euGenes: HUgn3234
    ECgene: HOXD8 H-InvDB: HOXD8

    Other Databases showing HOXD8 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HOXD8 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HOXD8 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HOXD8 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HOXD8 gene:
    Search GeneIP for patents involving HOXD8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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