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HOXD8 Gene

protein-coding   GIFtS: 53
GCID: GC02P176994

Homeobox D8

(Previous name: homeo box D8)
(Previous symbols: HOX4, HOX4E)
  Search for HOXD8
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Homeobox D81 2     HOX5.42
HOX4E1 2 3 5     Hox-4.52
HOX41 2     Homeo Box 4E2
Homeo Box D81 2     Homeobox Protein 5.42
Homeobox Protein Hox-4E2 3     Homeobox Protein Hox-D82
Homeobox Protein Hox-5.42 3     

External Ids:    HGNC: 51391   Entrez Gene: 32342   Ensembl: ENSG000001758797   OMIM: 1429855   UniProtKB: P133783   

Export aliases for HOXD8 gene to outside databases

Previous GC identifers: GC02P175047 GC02P175655 GC02P176958 GC02P177197 GC02P177195 GC02P176819 GC02P176702 GC02P168871


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HOXD8 Gene:
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of
transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals
possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes,
consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a
cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have
been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this
particular gene may also play a role in adult urogenital tract function. Alternate splicing results in multiple
transcript variants.(provided by RefSeq, Dec 2010)

GeneCards Summary for HOXD8 Gene:
HOXD8 (homeobox D8) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is HOXA7.

UniProtKB/Swiss-Prot: HXD8_HUMAN, P13378
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXD8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the HOXD8 gene promoter:
         E2F-3a   E2F-4   E2F-5   HTF   Nkx2-5   E2F-2   E2F   E2F-1   HOXA5   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for HOXD8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HOXD8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

HOXD8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXD8 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P176994:  view genomic region     (about GC identifiers)

Start:
176,994,422 bp from pter      End:
176,997,423 bp from pter
Size:
3,002 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HXD8_HUMAN, P13378 (See protein sequence)
Recommended Name: Homeobox protein Hox-D8  
Size: 290 amino acids; 31911 Da
Secondary accessions: F8WBG7 Q5BL00 Q8IXZ1
Alternative splicing: 3 isoforms:  P13378-1   P13378-2   P13378-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HOXD8: NX_P13378

Explore proteomics data for HOXD8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HOXD8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001186675.1  NP_001186676.1  NP_062458.1  

    ENSEMBL proteins: 
     ENSP00000406045   ENSP00000315949   ENSP00000448196   ENSP00000409026   ENSP00000437431  

    HOXD8 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for HOXD8
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    Novus Biologicals HOXD8 Proteins
    Novus Biologicals HOXD8 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HOXD8

     
    Search eBioscience for Proteins for HOXD8 

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    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Cloud-Clone Corp. ELISAs for HOXD8
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    Search eBioscience for ELISAs for HOXD8 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HOXL: Homeoboxes / ANTP class : HOXL subclass

    5 InterPro protein domains:
     IPR001827 Homeobox_Antennapedia_CS
     IPR020479 Homeobox_metazoa
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P13378

    ProtoNet protein and cluster: P13378

    1 Blocks protein domain: IPB001827 Homeobox protein

    UniProtKB/Swiss-Prot: HXD8_HUMAN, P13378
    Similarity: Belongs to the Antp homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Find genes that share domains with HOXD8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HXD8_HUMAN, P13378
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
    cells with specific positional identities on the anterior-posterior axis

         Genatlas biochemistry entry for HOXD8:
    homeo box D8(4E),homologous to mouse Hox-4.3,Drosophila antp,Ubx,abd-A

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with HOXD8           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Hoxd8):
     skeleton 

    Find genes that share phenotypes with HOXD8           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Hoxd8tm1Jdes for HOXD8

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HOXD8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HOXD8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HOXD8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HOXD8

    miRNA
    Products:
        
    miRTarBase miRNAs that target HOXD8:
    hsa-mir-196a-5p (MIRT002941)

    Block miRNA regulation of human, mouse, rat HOXD8 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate HOXD8:
    hsa-miR-3671 hsa-miR-142-5p hsa-miR-4325 hsa-miR-519c-3p hsa-miR-519a hsa-miR-519b-3p hsa-miR-335
    SwitchGear 3'UTR luciferase reporter plasmidHOXD8 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HOXD8
    Predesigned siRNA for gene silencing in human, mouse, rat HOXD8

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): HOXD8 (NM_001199747)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXD8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXD8
    Addgene plasmids for HOXD8 

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    Browse ESI BIO Cell Lines and PureStem Progenitors for HOXD8 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXD8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HXD8_HUMAN, P13378: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS2568311

    Find genes that share ontologies with HOXD8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including HOXD8: 
              Homeobox (HOX) Genes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for HOXD8

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    Selected Interacting proteins for HOXD8 (P133782, 3 ENSP000003159494) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANXA7P200732, 3MINT-8248461 I2D: score=2 
    CDKN1AP389362, 3MINT-8251970 I2D: score=2 
    PFDN1O609252, 3MINT-8265875 I2D: score=2 
    RCC1P187542, 3MINT-8268416 I2D: score=2 
    HMGB1P094293, ENSP000003430404I2D: score=1 STRING: ENSP00000343040
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007275multicellular organismal development ----
    GO:0008595anterior/posterior axis specification, embryo NAS2568311

    Find genes that share ontologies with HOXD8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HOXD8 (HXD8)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HOXD8 gene (3 alternative transcripts): 
    NM_001199746.1  NM_001199747.1  NM_019558.3  

    Unigene Cluster for HOXD8:

    Homeobox D8
    Hs.301963  [show with all ESTs]
    Unigene Representative Sequence: NM_019558
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000429017 ENST00000313173(uc002ukn.3 uc002ukp.3 uc002uko.3)
    ENST00000548663 ENST00000450510 ENST00000544999
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HOXD8 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate HOXD8:
    hsa-miR-3671 hsa-miR-142-5p hsa-miR-4325 hsa-miR-519c-3p hsa-miR-519a hsa-miR-519b-3p hsa-miR-335
    SwitchGear 3'UTR luciferase reporter plasmidHOXD8 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HOXD8
    Predesigned siRNA for gene silencing in human, mouse, rat HOXD8
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): HOXD8 (NM_001199747)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXD8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXD8
    Addgene plasmids for HOXD8 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for HOXD8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HOXD8
      QuantiTect SYBR Green Assays in human, mouse, rat HOXD8
      QuantiFast Probe-based Assays in human, mouse, rat HOXD8

    Additional mRNA sequence: 

    BC038709.1 BC090853.1 

    4 DOTS entries:

    DT.86849849  DT.91650475  DT.106454  DT.120935760 

    Selected AceView cDNA sequences (see all 36):

    NM_019558 CR613054 CR613626 AW140108 AI521778 BC038709 BF057634 BX097161 
    BI764317 BQ429720 AL530925 AL520835 AI936395 T29810 W81629 AI129333 
    AA905044 AI093486 AI300186 AL520834 BG432602 AI222194 AI623322 AW197515 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for HOXD8    About this scheme

    ExUns: 1 ^ 2a · 2b
    SP1:                  
    SP2:                  


    ECgene alternative splicing isoforms for HOXD8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HOXD8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCACTGCTCT
    HOXD8 Expression
    About this image


    HOXD8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Somite (Muscoskeletal System)    fully expand to see all 4 entries
             Thoracic Sclerotome Cells Thoracic Mesenchymal Sclerotome
             Lumbar Mesenchymal Sclerotome
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Thoracic Sclerotome Cells Thoracic Mesenchymal Sclerotome
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Thoracic Sclerotome Cells Thoracic Mesenchymal Sclerotome
     
     Tendon & Ligament
             Thoracic Sclerotome Cells Thoracic Mesenchymal Sclerotome
     
     Kidney (Urinary System)
             Metanephros
    HOXD8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HOXD8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.301963
        Pathway & Disease-focused RT2 Profiler PCR Array including HOXD8: 
              Homeobox (HOX) Genes in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXD8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HOXD8 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hoxd81 , 5 homeobox D81, 5 90.2(n)1
    89.96(a)1
      2 (44.13 cM)5
    154371  NM_008276.21  NP_032302.21 
     747046155 
    chicken
    (Gallus gallus)
    Aves HOXD81 homeobox D8 81.14(n)
    82.44(a)
      396301  NM_207177.1  NP_997060.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC685882 hypothetical protein MGC68588 79.39(n)    BC060408.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ubx6
    abd-A6
    abdominal A
    23(a)
    15(a)
    many ↔ many
    many ↔ many
    3R(12482345-12560348)
    3R(12632936-12655767)
    worm
    (Caenorhabditis elegans)
    Secernentea mab-56
    lin-396
    Protein LIN-39 (lin-39) mRNA, complete cds
    33(a)
    26(a)
    many ↔ many
    many ↔ many
    III(7776907-7783454) WBGene00003102
    III(7528668-7536632) WBGene00003024


    ENSEMBL Gene Tree for HOXD8 (if available)
    TreeFam Gene Tree for HOXD8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HOXD8 gene
    HOXA72  HOXB52  HOXC62  HOXC52  HOXB42  HOXA52  ENSG000002732662  HOXA42  
    HOXC82  HOXA62  ENSG000002730492  HOXB62  HOXB82  HOXD42  HOXB72  HOXC42  
    Selected SIMAP similar genes for HOXD8 using alignment to 2 protein entries:     HXD8_HUMAN (see all proteins) (see all similar genes):
    HOXA4    HOXB3    HOXA3    HOXC4    HOXB8    HOXC8
    HHEX    HOXB5    HOXD9    HOXA10    HOXB7    HOXA6
    HOXA-9    HOXC5    HLX    HOXC6    HOXD3    MNX1

    Find genes that share paralogs with HOXD8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HOXD8 (see all 125)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1475707711,2
    C--176992442(+) CATTT-/C/CCCC
            
    TCCCC
    1 -- us2k10--------
    rs39031191,2
    C,F--176992443(+) CATTTC/TCCCCC 1 -- us2k1 tfbs3 trp32Minor allele frequency- T:0.50NA CSA 4
    rs359320781,2
    C--176992443(+) ATTTT-/C/CC  
     
    /CCCC/G
    CCCCC
    1 -- us2k10--------
    rs3703539641,2
    C--176992443(+) CATTT-/CC/T  
            
    CCCCC
    1 -- us2k10--------
    rs8471641,2
    C,F,A,H--176992444(-) GGGGGA/GAAAAT 1 -- us2k1 tfbs3 trp35Minor allele frequency- G:0.22WA NA CSA 9
    rs1504668541,2
    C--176992491(+) TTCAA-/ACA   
       CACAC
    ACACA
    3 -- us2k10--------
    rs13179261,2
    C--176992527(+) acacaC/GGCCAA 2 -- us2k1 tfbs30--------
    rs283675321,2
    C--176992527(+) ACACAG/CGCCAA 3 -- us2k1 tfbs31Minor allele frequency- C:0.00NA 2
    rs1496478941,2
    C,F--176992527(+) cacac-/ACAC/ACACACAC/ACACACACAC/ACACAC
    ACACACACAC
    /ACACACACAG/ACACACAG/AG
    GCCAA
    2 -- us2k12NA 4
    rs677790321,2
    C--176992528(+) ACACG-/ACACACA/A
    CACACAG
    /ACAG
    CCAAA
    3 -- us2k10--------

    HapMap Linkage Disequilibrium report for HOXD8 (176994422 - 176997423 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for HOXD8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv875446CNV Loss21882294
    nsv875437CNV Loss21882294
    nsv517968CNV Loss19592680
    nsv875438CNV Loss21882294
    nsv821805CNV Gain20364138
    dgv676n67CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142985    OMIM disorders: --


    Find genes that share disorders with HOXD8           About GenesLikeMe

    Genetic Association Database (GAD): HOXD8
    Human Genome Epidemiology (HuGE) Navigator: HOXD8 (3 documents)

    Export disorders for HOXD8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HOXD8 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with HOXD8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot. (PubMed id 19938081)1, 4 Ester A.R....Hecht J.T. (Am. J. Med. Genet. A 2009)
    2. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    3. Complete mutation analysis panel of the 39 human HOX genes. (PubMed id 11857506)1, 2 Kosaki K.... Matsuo N. (Teratology 2002)
    4. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (Cell 1992)
    5. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (Genomics 1990)
    6. Complementary homeo protein gradients in developing limb buds. (PubMed id 2568311)1, 2 Oliver G.... De Robertis E.M. (Genes Dev. 1989)
    7. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    8. Identification of targets of Prox1 during in vitro vascular differentiation from embryonic stem cells: functional roles of HoxD8 in lymphangiogenesis. (PubMed id 19825936)1 Harada K....Miyazono K. (J. Cell. Sci. 2009)
    9. Hepatitis C virus infection protein network. (PubMed id 18985028)1 de Chassey B....Lotteau V. (Mol. Syst. Biol. 2008)
    10. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3234 HGNC: 5139 AceView: HOXD8 Ensembl:ENSG00000175879 euGenes: HUgn3234
    ECgene: HOXD8 H-InvDB: HOXD8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HOXD8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HOXD8 gene:
    Search GeneIP for patents involving HOXD8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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