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Aliases for HOXD8 Gene

Aliases for HOXD8 Gene

  • Homeobox D8 2 3
  • HOX4E 3 4 6
  • Homeobox Protein Hox-5.4 3 4
  • Homeobox Protein Hox-4E 3 4
  • Homeo Box D8 2 3
  • Homeobox Protein Hox-D8 3
  • Homeobox Protein 5.4 3
  • Homeo Box 4E 3
  • Hox-4.5 3
  • HOX5.4 3
  • HOX4 3

External Ids for HOXD8 Gene

Previous HGNC Symbols for HOXD8 Gene

  • HOX4
  • HOX4E

Previous GeneCards Identifiers for HOXD8 Gene

  • GC02P175047
  • GC02P175655
  • GC02P176958
  • GC02P177197
  • GC02P177195
  • GC02P176819
  • GC02P176702
  • GC02P168871
  • GC02P176994

Summaries for HOXD8 Gene

Entrez Gene Summary for HOXD8 Gene

  • This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]

GeneCards Summary for HOXD8 Gene

HOXD8 (Homeobox D8) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HOXA7.

UniProtKB/Swiss-Prot for HOXD8 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXD8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXD8 Gene

Genomics for HOXD8 Gene

Regulatory Elements for HOXD8 Gene

Genomic Location for HOXD8 Gene

Start:
176,129,694 bp from pter
End:
176,132,695 bp from pter
Size:
3,002 bases
Orientation:
Plus strand

Genomic View for HOXD8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HOXD8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXD8 Gene

Proteins for HOXD8 Gene

  • Protein details for HOXD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13378-HXD8_HUMAN
    Recommended name:
    Homeobox protein Hox-D8
    Protein Accession:
    P13378
    Secondary Accessions:
    • F8WBG7
    • Q5BL00
    • Q8IXZ1

    Protein attributes for HOXD8 Gene

    Size:
    290 amino acids
    Molecular mass:
    31911 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HOXD8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HOXD8 Gene

Proteomics data for HOXD8 Gene at MOPED

Post-translational modifications for HOXD8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXD8 Gene

No data available for DME Specific Peptides for HOXD8 Gene

Domains for HOXD8 Gene

Gene Families for HOXD8 Gene

HGNC:
  • HOXL :Homeoboxes / ANTP class : HOXL subclass

Suggested Antigen Peptide Sequences for HOXD8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P13378

UniProtKB/Swiss-Prot:

HXD8_HUMAN :
  • P13378
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the Antp homeobox family.
genes like me logo Genes that share domains with HOXD8: view

Function for HOXD8 Gene

Molecular function for HOXD8 Gene

GENATLAS Biochemistry: homeo box D8(4E),homologous to mouse Hox-4.3,Drosophila antp,Ubx,abd-A
UniProtKB/Swiss-Prot Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Gene Ontology (GO) - Molecular Function for HOXD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 1756725
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 1756725
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0043565 sequence-specific DNA binding --
genes like me logo Genes that share ontologies with HOXD8: view

Phenotypes for HOXD8 Gene

MGI mutant phenotypes for HOXD8:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with HOXD8: view

Animal Models for HOXD8 Gene

MGI Knock Outs for HOXD8:

miRNA for HOXD8 Gene

miRTarBase miRNAs that target HOXD8

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HOXD8 Gene

Localization for HOXD8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXD8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOXD8 Gene COMPARTMENTS Subcellular localization image for HOXD8 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HOXD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 2568311
genes like me logo Genes that share ontologies with HOXD8: view

Pathways for HOXD8 Gene

SuperPathways for HOXD8 Gene

No Data Available

Interacting Proteins for HOXD8 Gene

Gene Ontology (GO) - Biological Process for HOXD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0008595 anterior/posterior axis specification, embryo NAS 2568311
GO:0009952 anterior/posterior pattern specification --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 1756725
genes like me logo Genes that share ontologies with HOXD8: view

No data available for Pathways by source for HOXD8 Gene

Transcripts for HOXD8 Gene

Unigene Clusters for HOXD8 Gene

Homeobox D8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HOXD8 Gene

ExUns: 1 ^ 2a · 2b
SP1:
SP2:

Relevant External Links for HOXD8 Gene

GeneLoc Exon Structure for
HOXD8
ECgene alternative splicing isoforms for
HOXD8

Expression for HOXD8 Gene

mRNA expression in normal human tissues for HOXD8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXD8 Gene

This gene is overexpressed in Kidney - Cortex (8.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HOXD8 Gene

SOURCE GeneReport for Unigene cluster for HOXD8 Gene Hs.301963

genes like me logo Genes that share expressions with HOXD8: view

No data available for mRNA Expression by UniProt/SwissProt for HOXD8 Gene

Orthologs for HOXD8 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOXD8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOXD8 35
  • 99.77 (n)
  • 99.31 (a)
HOXD8 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HOXD8 35
  • 91.91 (n)
  • 93.48 (a)
dog
(Canis familiaris)
Mammalia HOXD8 35
  • 94.61 (n)
  • 96.46 (a)
HOXD8 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hoxd8 35
  • 90.2 (n)
  • 89.96 (a)
Hoxd8 16
Hoxd8 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HOXD8 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HOXD8 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves HOXD8 35
  • 81.14 (n)
  • 82.44 (a)
HOXD8 36
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68588 35
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxd8 35
  • 74.3 (n)
  • 70.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta abd-A 36
  • 15 (a)
ManyToMany
Ubx 36
  • 23 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea lin-39 36
  • 26 (a)
ManyToMany
mab-5 36
  • 33 (a)
ManyToMany
Species with no ortholog for HOXD8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for HOXD8 Gene

ENSEMBL:
Gene Tree for HOXD8 (if available)
TreeFam:
Gene Tree for HOXD8 (if available)

Paralogs for HOXD8 Gene

Selected SIMAP similar genes for HOXD8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HOXD8: view

Variants for HOXD8 Gene

Sequence variations from dbSNP and Humsavar for HOXD8 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs36051423 -- 176,132,850(+) AAAAA(-/A)GGCCG downstream-variant-500B
rs78045814 -- 176,133,161(+) TAACA(C/T)TCCCG downstream-variant-500B
rs111760092 -- 176,132,459(+) TTCCG(C/T)TATTT utr-variant-3-prime
rs112559843 -- 176,132,547(+) CAGAC(A/G)TCGGT utr-variant-3-prime
rs114763776 -- 176,132,851(+) AAAAA(A/G)GCCGC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for HOXD8 Gene

Variant ID Type Subtype PubMed ID
dgv676n67 CNV Gain 20364138
nsv875437 CNV Loss 21882294
nsv875438 CNV Loss 21882294
nsv517968 CNV Loss 19592680
nsv875446 CNV Loss 21882294
nsv821805 CNV Gain 20364138

Relevant External Links for HOXD8 Gene

HapMap Linkage Disequilibrium report
HOXD8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXD8 Gene

Disorders for HOXD8 Gene

Relevant External Links for HOXD8

Genetic Association Database (GAD)
HOXD8
Human Genome Epidemiology (HuGE) Navigator
HOXD8
genes like me logo Genes that share disorders with HOXD8: view

No data available for UniProtKB/Swiss-Prot for HOXD8 Gene

Publications for HOXD8 Gene

  1. Nomenclature for human homeobox genes. (PMID: 1973146) McAlpine P.J. … Shows T.B. (Genomics 1990) 2 3
  2. Complementary homeo protein gradients in developing limb buds. (PMID: 2568311) Oliver G. … De Robertis E.M. (Genes Dev. 1989) 3 4
  3. Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott M.P. (Cell 1992) 2 3
  4. Complete mutation analysis panel of the 39 human HOX genes. (PMID: 11857506) Kosaki K. … Matsuo N. (Teratology 2002) 3 4
  5. Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot. (PMID: 19938081) Ester A.R. … Hecht J.T. (Am. J. Med. Genet. A 2009) 3 48

Products for HOXD8 Gene

  • Addgene plasmids for HOXD8

Sources for HOXD8 Gene

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