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HOXD4 Gene

protein-coding   GIFtS: 55
GCID: GC02P177034

Homeobox D4

(Previous name: homeo box D4)
(Previous symbols: HOX4B, HOX4)
  See HOXD4-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Homeobox D41 2     Homeo Box D41
HOX4B1 2 3 5     HHO.C132
HOX41 2     HOX-5.12
Homeobox Protein HHO.C132 3     Hox-4.22
Homeobox Protein Hox-4B2 3     Homeobox Protein Hox-D42
Homeobox Protein Hox-5.12 3     Hox-4.2, Mouse, Homolog Of Homeo Box X2

External Ids:    HGNC: 51381   Entrez Gene: 32332   Ensembl: ENSG000001701667   OMIM: 1429815   UniProtKB: P090163   

Export aliases for HOXD4 gene to outside databases

Previous GC identifers: GC02P175067 GC02P175677 GC02P176980 GC02P177218 GC02P176841 GC02P176724 GC02P177016 GC02P168892 GC02P177019 GC02P177022 GC02P177026 GC02P177030


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HOXD4 Gene:
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of
transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals
possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes,
consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at
2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have
been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in
determining positional values in developing limb buds. Alternatively spliced variants have been described but
their full length nature has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for HOXD4 Gene:
HOXD4 (homeobox D4) is a protein-coding gene. Diseases associated with HOXD4 include clubfoot. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is HOXA7.

UniProtKB/Swiss-Prot: HXD4_HUMAN, P09016
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXD4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HOXD4 gene promoter:
         HOXA9B   HOXA9   Nkx2-5   Gfi-1   c-Ets-1   HOXA5   COMP1   FOXO1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HOXD4 promoter sequence
   Search Chromatin IP Primers for HOXD4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HOXD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

HOXD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXD4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P177034:  view genomic region     (about GC identifiers)

Start:
177,015,950 bp from pter      End:
177,017,954 bp from pter
Size:
2,005 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HXD4_HUMAN, P09016 (See protein sequence)
Recommended Name: Homeobox protein Hox-D4  
Size: 255 amino acids; 27885 Da
Secondary accessions: B2R9R3 Q96AU0

Explore the universe of human proteins at neXtProt for HOXD4: NX_P09016

Explore proteomics data for HOXD4 at MOPED


See HOXD4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_055436.2  
ENSEMBL proteins: 
 ENSP00000302548  

HOXD4 Human Recombinant Protein Products:

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Novus Biologicals HOXD4 Lysate
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Cloud-Clone Corp. Proteins for HOXD4

 
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EMD Millipore Mono- and Polyclonal Antibodies for the study of HOXD4
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Abcam antibodies for HOXD4
Cloud-Clone Corp. Antibodies for HOXD4
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LSBio Antibodies in human, mouse, rat for HOXD4

HOXD4 Assay Products:

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GenScript Custom Assay Services for HOXD4
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for HOXD4
Cloud-Clone Corp. CLIAs for HOXD4
Search eBioscience for ELISAs for HOXD4 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
HOXL: Homeoboxes / ANTP class : HOXL subclass

Selected InterPro protein domains (see all 6):
 IPR001827 Homeobox_Antennapedia_CS
 IPR020479 Homeobox_metazoa
 IPR017995 Homeobox_antennapedia
 IPR017970 Homeobox_CS
 IPR001356 Homeobox_dom

Graphical View of Domain Structure for InterPro Entry P09016

ProtoNet protein and cluster: P09016

1 Blocks protein domain: IPB001827 Homeobox protein

UniProtKB/Swiss-Prot: HXD4_HUMAN, P09016
Similarity: Belongs to the Antp homeobox family. Deformed subfamily
Similarity: Contains 1 homeobox DNA-binding domain


Find genes that share domains with HOXD4           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: HXD4_HUMAN, P09016
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
cells with specific positional identities on the anterior-posterior axis

     Genatlas biochemistry entry for HOXD4:
homeo box D4(4B),homologous to mouse Hox-4.2,Drosophila Dfd

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding ----
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
GO:0043565sequence-specific DNA binding IEA--
     
Find genes that share ontologies with HOXD4           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for HOXD4:
 Decreased cell number 

     5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hoxd4):
 craniofacial  growth/size/body  mortality/aging  reproductive system  skeleton 

Find genes that share phenotypes with HOXD4           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Hoxd4tm1Bhr for HOXD4

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HOXD4
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HOXD4

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HOXD4
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HOXD4

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat HOXD4 using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate HOXD4:
hsa-miR-222*
SwitchGear 3'UTR luciferase reporter plasmidHOXD4 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for HOXD4
Predesigned siRNA for gene silencing in human, mouse, rat HOXD4

Gene Editing
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DNA2.0 Custom Protein Engineering Service for HOXD4

Clone
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OriGene clones in human, mouse for HOXD4 (see all 6)
OriGene ORF clones in mouse, rat for HOXD4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: HOXD4 (NM_014621)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXD4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXD4

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXD4

Flow Cytometry
Products:
   

 
eBioscience FlowRNA Probe Sets ( VA6-10774) for HOXD4 


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
HXD4_HUMAN, P09016: Nucleus
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Pathway & Disease-focused RT2 Profiler PCR Arrays including HOXD4: 
          Stem Cell Transcription Factors in human mouse rat
          Homeobox (HOX) Genes in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for HOXD4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for HOXD4 (P090163 ENSP000003025484) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
InteractantInteraction Details
GeneCardExternal ID(s)
ASB8Q9H7653, ENSP000003208934I2D: score=1 STRING: ENSP00000320893
DEDDO756183, ENSP000003569854I2D: score=1 STRING: ENSP00000356985
HOXB13Q928263, ENSP000002902954I2D: score=1 STRING: ENSP00000290295
MEIS1O004703, ENSP000002723694I2D: score=1 STRING: ENSP00000272369
XRCC6P129563, ENSP000003522574I2D: score=1 STRING: ENSP00000352257
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Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated ----
GO:0007275multicellular organismal development NAS2879245

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for HOXD4 (HXD4)

1 Novoseek inferred chemical compound relationship for HOXD4 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
retinoic acid 30.6 2 7501971 (2)



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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for HOXD4 gene: 
NM_014621.2  

Unigene Cluster for HOXD4:

Homeobox D4
Hs.591609  [show with all ESTs]
Unigene Representative Sequence: X04706
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000306324(uc002uks.3)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat HOXD4 using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate HOXD4:
hsa-miR-222*
SwitchGear 3'UTR luciferase reporter plasmidHOXD4 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for HOXD4
Predesigned siRNA for gene silencing in human, mouse, rat HOXD4
Clone
Products:
     
OriGene clones in human, mouse for HOXD4 (see all 6)
OriGene ORF clones in mouse, rat for HOXD4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: HOXD4 (NM_014621)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXD4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXD4
Primer
Products:
    
OriGene qPCR primer pairs and template standards for HOXD4
OriGene qSTAR qPCR primer pairs in human, mouse for HOXD4
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HOXD4
  QuantiTect SYBR Green Assays in human, mouse, rat HOXD4
  QuantiFast Probe-based Assays in human, mouse, rat HOXD4
Flow Cytometry
Products:
   

 
eBioscience FlowRNA Probe Sets ( VA6-10774) for HOXD4 

Additional mRNA sequence: 

AK311735.1 AK313885.1 BC016763.1 BC074797.2 X04706.1 

2 DOTS entries:

DT.92419427  DT.120935783 

Selected AceView cDNA sequences (see all 53):

AA447692 BF061514 BG677525 AI913601 BX102979 BC016763 AI074140 AW168155 
AI671371 BQ008052 BE048811 AI168479 NM_014621 AW451394 BC074797 BF061522 
AI223819 AW452138 AI761605 BQ941558 BF061523 X04706 BX471755 AW949439 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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HOXD4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGTTCGTATA
HOXD4 Expression
About this image


HOXD4 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 8) fully expand
 
 Bone (Muscoskeletal System)    fully expand to see all 2 entries
         Cervical Sclerotome Cells Cervical Mesenchymal Sclerotome
 
 Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
         Cervical Sclerotome Cells Cervical Mesenchymal Sclerotome
 
 Tendon & Ligament
         Cervical Sclerotome Cells Cervical Mesenchymal Sclerotome
 
 Somite (Muscoskeletal System)
         Cervical Sclerotome Cells Cervical Mesenchymal Sclerotome
 
 Kidney (Urinary System)
         Metanephros
HOXD4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

HOXD4 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.591609
    Pathway & Disease-focused RT2 Profiler PCR Arrays including HOXD4: 
          Stem Cell Transcription Factors in human mouse rat
          Homeobox (HOX) Genes in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for HOXD4
OriGene qSTAR qPCR primer pairs in human, mouse for HOXD4
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HOXD4
QuantiTect SYBR Green Assays in human, mouse, rat HOXD4
QuantiFast Probe-based Assays in human, mouse, rat HOXD4
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXD4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for HOXD4 gene from Selected species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Hoxd41 , 5 homeobox D41, 5 87.6(n)1
90(a)1
  2 (44.13 cM)5
154361  NM_010469.21  NP_034599.21 
 747219785 
chicken
(Gallus gallus)
Aves HOXD41 homeobox D4 75.95(n)
75.11(a)
  424139  NM_001012293.1  NP_001012293.1 
lizard
(Anolis carolinensis)
Reptilia HOXD46
homeobox D4
74(a)
1 ↔ 1
GL343356.1(478136-480351)
African clawed frog
(Xenopus laevis)
Amphibia LOC3987442 HOXD4 77.16(n)    AY422086.1 
zebrafish
(Danio rerio)
Actinopterygii hoxd4a2 homeo box D4a 78.52(n)   30329  NM_130757.1 
fruit fly
(Drosophila melanogaster)
Insecta Scr3 midgut development specific RNA
polymerase II more
71(a)
(best of 2)
  3 84A5   --


ENSEMBL Gene Tree for HOXD4 (if available)
TreeFam Gene Tree for HOXD4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for HOXD4 gene
HOXA72  HOXB52  HOXC62  HOXC52  HOXB42  HOXA52  ENSG000002732662  HOXA42  
HOXC82  HOXA62  ENSG000002730492  HOXD82  HOXB62  HOXB82  HOXB72  HOXC42  
10 SIMAP similar genes for HOXD4 using alignment to 1 protein entry:     HXD4_HUMAN:
HOXA4    HOXC6    HOXC4    HOXB4    HOXA5    HOXC5
HOXB5    POU6F1    HOXA3    HOXA7

Find genes that share paralogs with HOXD4           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for HOXD4 (see all 84)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1048936361,2
Cother1176411472(+) ACAAGA/TGCCAG 2 E V mis10--------
rs2007122441,2
--176409050(+) CAGTT-/AAAAAA 1 -- us2k10--------
rs1848497951,2
--176409096(+) AAAAGC/TCCCAC 1 -- us2k10--------
rs748491241,2
C--176409434(+) AGGGC-/TGGCCATG 1 -- cds10--------
rs1897401321,2
--176409667(+) TTATTA/TTTCTT 1 -- us2k10--------
rs1816953811,2
--176409704(+) GAAGAA/CTATTC 1 -- us2k10--------
rs1860367701,2
--176409738(+) CCTGAC/TCCTGG 1 -- us2k10--------
rs1471946331,2
--176409744(+) CCTGGC/TAGAAG 1 -- us2k10--------
rs18678631,2
C,F,A,H--176409839(-) GCCACC/AACCGT 1 -- us2k115Minor allele frequency- A:0.32MN NA NS EA WA 1150
rs2000156431,2
C--176410008(+) AACTTC/TACGTT 1 -- us2k11Minor allele frequency- T:0.00EU 1301

HapMap Linkage Disequilibrium report for HOXD4 (177015950 - 177017954 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for HOXD4:    About this table    
Variant IDTypeSubtypePubMed ID
nsv875446CNV Loss21882294
nsv875438CNV Loss21882294
dgv676n67CNV Gain20364138

Human Gene Mutation Database (HGMD): HOXD4
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing HOXD4
DNA2.0 Custom Variant and Variant Library Synthesis for HOXD4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 142981    OMIM disorders: --

1 disease for HOXD4:    
About MalaCards
clubfoot

1 disease from the University of Copenhagen DISEASES database for HOXD4:
Embryonal carcinoma

Find genes that share disorders with HOXD4           About GenesLikeMe

Genetic Association Database (GAD): HOXD4
Human Genome Epidemiology (HuGE) Navigator: HOXD4 (5 documents)

Export disorders for HOXD4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for HOXD4 gene, integrated from 10 sources (see all 33):
(articles sorted by number of sources associating them with HOXD4)
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  1. Mutation analysis of the HOX paralogous 4-13 genes in children with acute lymphoid malignancies: identification of a novel germline mutation of HOXD4 leading to a partial loss-of-function. (PubMed id 15776434)1, 4, 9 van Scherpenzeel Thim V....Verellen-Dumoulin C. (Hum. Mutat. 2005)
  2. Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot. (PubMed id 19938081)1, 4 Ester A.R....Hecht J.T. (Am. J. Med. Genet. A 2009)
  3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (Cell 1992)
  6. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (Genomics 1990)
  7. Molecular mechanisms underlying the expression of the human HOX-5.1 gene. (PubMed id 1975093)1, 2 Cianetti L.... Peschle C. (Nucleic Acids Res. 1990)
  8. Organization of human class I homeobox genes. (PubMed id 2576652)1, 2 Boncinelli E.... Simeone A. (Genome 1989)
  9. Differential and stage-related expression in embryonic tissues of a new human homoeobox gene. (PubMed id 2879245)1, 2 Mavilio F.... Boncinelli E. (Nature 1986)
  10. PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins. (PubMed id 10523646)1, 9 Shanmugam K....Featherstone M.S. (Mol. Cell. Biol. 1999)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3233 HGNC: 5138 AceView: HOXD4 Ensembl:ENSG00000170166 euGenes: HUgn3233
ECgene: HOXD4 H-InvDB: HOXD4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for HOXD4 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for HOXD4 gene:
Search GeneIP for patents involving HOXD4

GeneCards and IP:
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