Aliases for HOXD4 Gene
Aliases for HOXD4 Gene
External Ids for HOXD4 Gene
- HGNC: 5138
- Entrez Gene: 3233
- Ensembl: ENSG00000170166
- OMIM: 142981
- UniProtKB: P09016
Previous HGNC Symbols for HOXD4 Gene
- HOX4B
- HOX4
Previous GeneCards Identifiers for HOXD4 Gene
- GC02P175067
- GC02P175677
- GC02P176980
- GC02P177218
- GC02P176841
- GC02P176724
- GC02P177016
- GC02P168892
- GC02P177019
- GC02P177022
- GC02P177026
- GC02P177030
- GC02P177034
- GC02P176152
- GC02P176154
- GC02P176156
- GC02P176158
- GC02P176160
Summaries for HOXD4 Gene
-
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in determining positional values in developing limb buds. Alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOXD4 Gene
HOXD4 (Homeobox D4) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Developmental Biology. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is HOXC4.
UniProtKB/Swiss-Prot for HOXD4 Gene
-
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXD4 Gene
Genomics for HOXD4 Gene
Regulatory Elements for HOXD4 Gene
Regulatory Element Products
Genomic Location for HOXD4 Gene
- Chromosome:
- 2
- Start:
- 176,150,394 bp from pter
- End:
- 176,153,226 bp from pter
- Size:
- 2,833 bases
- Orientation:
- Plus strand
Genomic View for HOXD4 Gene
- Cytogenetic band:
-
- 2q31.1 by Ensembl
- 2q31.1 by Entrez Gene
- 2q31.1 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HOXD4 Gene
Proteins for HOXD4 Gene
-
Protein details for HOXD4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P09016-HXD4_HUMAN
- Recommended name:
- Homeobox protein Hox-D4
- Protein Accession:
- P09016
- B2R9R3
- Q96AU0
Protein attributes for HOXD4 Gene
- Size:
- 255 amino acids
- Molecular mass:
- 27885 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for HOXD4 Gene
Other Protein References for HOXD4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HOXD4
- Novus Biologicals Antibodies for HOXD4
- Invitrogen Antibodies for HOXD4
- antibodies-online Antibodies for HOXD4: See all 32
- Search GeneTex for Antibodies for HOXD4
Protein Products
-
OriGene Purified Proteins for HOXD4
- Search Origene for MassSpec and Protein Over-expression Lysates for HOXD4
- Origene Custom Protein Services for HOXD4
- antibodies-online Proteins for HOXD4: See all 14
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HOXD4
Assay Products
No data available for DME Specific Peptides for HOXD4 Gene
Domains & Families for HOXD4 Gene
Gene Families for HOXD4 Gene
Protein Domains for HOXD4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HOXD4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P09016- Family:
-
- Belongs to the Antp homeobox family. Deformed subfamily.
Function for HOXD4 Gene
Molecular function for HOXD4 Gene
- GENATLAS Biochemistry:
- homeo box D4(4B),homologous to mouse Hox-4.2,Drosophila Dfd
- UniProtKB/Swiss-Prot Function:
- Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IMP | 1756725 |
| GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | IMP | 1756725 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | IEA | -- |
| GO:0043565 | sequence-specific DNA binding | IEA | -- |
Phenotypes for HOXD4 Gene
- MGI mutant phenotypes for HOXD4:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HOXD4:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Increased G1 DNA content
- Decreased Aire reporter expression
- Synthetic lethal with vaccinia virus (VACV) infection
- Weakly decreased NFAT1-GFP nuclear translocation
Animal Models for HOXD4 Gene
- MGI Knock Outs for HOXD4:
-
- Hoxd4 tm1Bhr
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXD4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXD4 gene
- Search ViGene Biosciences for HOXD4
CRISPR Products
-
OriGene CRISPR knockouts for HOXD4
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXD4
- GenScript: Design CRISPR guide RNA sequences for HOXD4
miRNA for HOXD4 Gene
- miRTarBase miRNAs that target HOXD4
miRNA Products
- Search ViGene Biosciences for HOXD4
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HOXD4
- Browse OriGene Inhibitory RNA Products For HOXD4
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXD4 gene
Clone Products
-
OriGene ORF clones in human for HOXD4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for HOXD4
-
ViGene Biosciences adenoviral particle packaged cDNA for HOXD4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXD4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXD4 gene
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA6-10774) for HOXD4
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXD4 Gene
Localization for HOXD4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HOXD4 Gene
- Nucleus.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0030054 | cell junction | IDA | -- |
Pathways & Interactions for HOXD4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||
| 2 | Developmental Biology | ||
Pathways by source for HOXD4 Gene
Interacting Proteins for HOXD4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006366 | transcription from RNA polymerase II promoter | IEA | -- |
| GO:0007275 | multicellular organism development | NAS | 2879245 |
| GO:0009952 | anterior/posterior pattern specification | IEA | -- |
No data available for SIGNOR curated interactions for HOXD4 Gene
Transcripts for HOXD4 Gene
mRNA/cDNA for HOXD4 Gene
- (2) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (53) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HOXD4
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXD4
- GenScript: Design CRISPR guide RNA sequences for HOXD4
miRNA Products
- Search ViGene Biosciences for HOXD4
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HOXD4
- Browse OriGene Inhibitory RNA Products For HOXD4
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXD4 gene
Clone Products
-
OriGene ORF clones in human for HOXD4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA6-10774) for HOXD4
Expression for HOXD4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Sclerotome Cells Cervical Mesenchymal Sclerotome
- Prechondrocytic Mesenchymal Cells Zeugopod
-
Cartilage (Muscoskeletal System)
- Sclerotome Cells Cervical Mesenchymal Sclerotome
- Prechondrocytic Mesenchymal Cells Zeugopod
-
Somite (Muscoskeletal System)
- Sclerotome Cells Cervical Mesenchymal Sclerotome
-
Tendon amp Ligament
- Sclerotome Cells Cervical Mesenchymal Sclerotome
-
Limb (Muscoskeletal System)
- Prechondrocytic Mesenchymal Cells Zeugopod
- Kidney (Urinary System)
NURSA nuclear receptor signaling pathways regulating expression of HOXD4 Gene:
HOXD4SOURCE GeneReport for Unigene cluster for HOXD4 Gene:
Hs.591609Evidence on tissue expression from TISSUES for HOXD4 Gene
- Kidney(4.1)
Primer Products
-
OriGene qPCR primer pairs for HOXD4
-
OriGene qPCR primer pairs and template standards for HOXD4
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXD4 Gene
Orthologs for HOXD4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HOXD4 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HOXD4 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hoxd4 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Hoxd4 34 16 |
|
||
| dog (Canis familiaris) |
Mammalia | HOXD4 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | HOXD4 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | HOXD4 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HOXD4 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HOXD4 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hoxd4 34 |
|
||
| Str.15492 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398744 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hoxd4a 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Scr 36 |
|
|
|
| Dfd 36 35 |
|
||||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for HOXD4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HOXD4 Gene
Paralogs for HOXD4 Gene
(10) SIMAP similar genes for HOXD4 Gene using alignment to 1 proteins:
Variants for HOXD4 Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs104893636 | Uncertain significance | 176,151,875(+) | ACAAG(A/C/T)GCCAG | intron-variant, reference, missense | |
| rs1000334284 | -- | 176,150,841(+) | CCCAG(A/T)GGGGA | intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime | |
| rs1000430812 | -- | 176,150,499(+) | TTATT(A/T)CCTTG | intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime | |
| rs1000476286 | -- | 176,152,468(+) | GGCGG(C/G)AGGGA | intron-variant | |
| rs1000607670 | -- | 176,148,630(+) | GTGAG(A/G)GCTGC | intron-variant, upstream-variant-2KB |
Relevant External Links for HOXD4 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXD4 Gene
Disorders for HOXD4 Gene
Relevant External Links for HOXD4
No disorders were found for HOXD4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOXD4 Gene
Publications for HOXD4 Gene
- Mutation analysis of the HOX paralogous 4-13 genes in children with acute lymphoid malignancies: identification of a novel germline mutation of HOXD4 leading to a partial loss-of-function. (PMID: 15776434) van Scherpenzeel Thim V. … Verellen-Dumoulin C. (Hum. Mutat. 2005) 3 22 46 64
- High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 46 64
- Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot. (PMID: 19938081) Ester A.R. … Hecht J.T. (Am. J. Med. Genet. A 2009) 3 46 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins. (PMID: 10523646) Shanmugam K. … Featherstone M.S. (Mol. Cell. Biol. 1999) 3 22 64
Products for HOXD4 Gene
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- Custom Antibody ServicesOriGene Antibodies for HOXD4
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- OriGene qPCR primer pairs for HOXD4
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- GenScript: Design CRISPR guide RNA sequences for HOXD4
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- Novus Biologicals Antibodies for HOXD4
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- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for HOXD4: See all 32
- Search antibodies-online for kits
- antibodies-online Proteins for HOXD4: See all 14
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for HOXD4
- Search GeneTex for Proteins for HOXD4
- ViGene Biosciences adenoviral particle packaged cDNA for HOXD4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HOXD4 gene
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- Horizon Cell Lines for HOXD4
- Cyagen custom Knockout/knockin (KOKI) mouse models for HOXD4
- VectorBuilder custom plasmid, inducible vectors for HOXD4
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HOXD4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
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- (146) Cyagen
- (147) VectorBuilder
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- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer



