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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HOXD4 Gene

protein-coding   GIFtS: 57
GCID: GC02P177030

Homeobox D4

(Previous name: homeo box D4)
(Previous symbols: HOX4B, HOX4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Homeobox D41 2     Homeo Box D41
HOX4B1 2 3 5     HHO.C132
HOX41 2     HOX-5.12
Homeobox Protein HHO.C132 3     Hox-4.22
Homeobox Protein Hox-4B2 3     Homeobox Protein Hox-D42
Homeobox Protein Hox-5.12 3     Hox-4.2, Mouse, Homolog Of Homeo Box X2

External Ids:    HGNC: 51381   Entrez Gene: 32332   Ensembl: ENSG000001701667   OMIM: 1429815   UniProtKB: P090163   

Export aliases for HOXD4 gene to outside databases

Previous GC identifers: GC02P175067 GC02P175677 GC02P176980 GC02P177218 GC02P176841 GC02P176724 GC02P177016 GC02P168892 GC02P177019 GC02P177022 GC02P177026


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HOXD4 Gene:
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of
transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals
possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes,
consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at
2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have
been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in
determining positional values in developing limb buds. Alternatively spliced variants have been described but
their full length nature has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for HOXD4 Gene: 
HOXD4 (homeobox D4) is a protein-coding gene. Diseases associated with HOXD4 include clubfoot, and neuroblastoma. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is GSX1.

UniProtKB/Swiss-Prot: HXD4_HUMAN, P09016
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXD4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HOXD4 gene promoter:
         HOXA9B   HOXA9   Nkx2-5   Gfi-1   c-Ets-1   HOXA5   COMP1   FOXO1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HOXD4 promoter sequence
   Search SABiosciences Chromatin IP Primers for HOXD4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOXD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

HOXD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXD4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P177030:  view genomic region     (about GC identifiers)

Start:
177,015,950 bp from pter      End:
177,017,954 bp from pter
Size:
2,005 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HXD4_HUMAN, P09016 (See protein sequence)
Recommended Name: Homeobox protein Hox-D4  
Size: 255 amino acids; 27885 Da
Subcellular location: Nucleus
Secondary accessions: B2R9R3 Q96AU0

Explore the universe of human proteins at neXtProt for HOXD4: NX_P09016

Explore proteomics data for HOXD4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P09016

  • HOXD4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HOXD4 Protein Expression
    REFSEQ proteins: NP_055436.2  
    ENSEMBL proteins: 
     ENSP00000302548  

    Human Recombinant Protein Products for HOXD4: 
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    Novus Biologicals HOXD4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HOXD4 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--

    HOXD4 for ontologies           About GeneDecksing



    HOXD4 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for HOXD4 

    Assay Products for HOXD4: 
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    Cloud-Clone Corp. ELISAs for HOXD4 
    Cloud-Clone Corp. CLIAs for HOXD4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HOXL: Homeoboxes / ANTP class : HOXL subclass

    5/6 InterPro protein domains (see all 6):
     IPR001827 Homeobox_Antennapedia_CS
     IPR020479 Homeobox_metazoa
     IPR017995 Homeobox_antennapedia
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain

    Graphical View of Domain Structure for InterPro Entry P09016

    ProtoNet protein and cluster: P09016

    1 Blocks protein domain: IPB001827 Homeobox protein

    UniProtKB/Swiss-Prot: HXD4_HUMAN, P09016
    Similarity: Belongs to the Antp homeobox family. Deformed subfamily
    Similarity: Contains 1 homeobox DNA-binding domain


    HOXD4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HXD4_HUMAN, P09016
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
    cells with specific positional identities on the anterior-posterior axis

         Genatlas biochemistry entry for HOXD4:
    homeo box D4(4B),homologous to mouse Hox-4.2,Drosophila Dfd

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity NAS--
    GO:0043565sequence-specific DNA binding IEA--
         
    HOXD4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HOXD4:
     Decreased cell number 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hoxd4):
     craniofacial  growth/size  mortality/aging  reproductive system  skeleton 

    HOXD4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Hoxd4tm1Bhr for HOXD4

       inGenious Targeting Laboratory - Custom generated mouse model solutions for HOXD4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HOXD4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HOXD4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HOXD4 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXD4
    1 QIAGEN miScript miRNA Assays for microRNA that regulate HOXD4:
    hsa-miR-222*
    SwitchGear 3'UTR luciferase reporter plasmidHOXD4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HOXD4
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    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: HOXD4 (NM_014621)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXD4
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                         Customized lentivirus expression plasmids for stable overexpression of HOXD4 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXD4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HOXD4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/21 Interacting proteins for HOXD4 (P090163 ENSP000003025484) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ASB8Q9H7653, ENSP000003208934I2D: score=1 STRING: ENSP00000320893
    DEDDO756183, ENSP000003569854I2D: score=1 STRING: ENSP00000356985
    HOXB13Q928263, ENSP000002902954I2D: score=1 STRING: ENSP00000290295
    MEIS1O004703, ENSP000002723694I2D: score=1 STRING: ENSP00000272369
    XRCC6P129563, ENSP000003522574I2D: score=1 STRING: ENSP00000352257
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS--
    GO:0007275multicellular organismal development NAS2879245
    GO:0009952anterior/posterior pattern specification ----
    GO:0048704embryonic skeletal system morphogenesis ----

    HOXD4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HOXD4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HOXD4 (HXD4)

    1 Novoseek inferred chemical compound relationship for HOXD4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 30.6 2 7501971 (2)

    Search CenterWatch for drugs/clinical trials and news about HOXD4 / HXD4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HOXD4 gene: 
    NM_014621.2  

    Unigene Cluster for HOXD4:

    Homeobox D4
    Hs.591609  [show with all ESTs]
    Unigene Representative Sequence: X04706
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000306324(uc002uks.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXD4
    1 QIAGEN miScript miRNA Assays for microRNA that regulate HOXD4:
    hsa-miR-222*
    SwitchGear 3'UTR luciferase reporter plasmidHOXD4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HOXD4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXD4
    Clone
    Products:
         
    OriGene clones in human, mouse for HOXD4 (see all 7)
    OriGene ORF clones in mouse, rat for HOXD4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HOXD4 (NM_014621)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXD4
    Sirion Biotech Customized lentivirus for stable overexpression of HOXD4 
                         Customized lentivirus expression plasmids for stable overexpression of HOXD4 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HOXD4
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HOXD4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXD4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXD4

    Additional mRNA sequence: 

    AK311735.1 AK313885.1 BC016763.1 BC074797.2 X04706.1 

    2 DOTS entries:

    DT.92419427  DT.120935783 

    24/53 AceView cDNA sequences (see all 53):

    AI913601 BX102979 AI671371 BC016763 BF061514 AI074140 AW168155 AA447692 
    BQ008052 AW451394 BE048811 BG677525 BF061522 BC074797 NM_014621 AI223819 
    AI168479 AW452138 X04706 BX471755 BQ676986 AI628666 BF110631 AA999852 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HOXD4 expression in normal human tissues (normalized intensities)      HOXD4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTTCGTATA
    HOXD4 Expression
    About this image


    HOXD4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Somite (Muscoskeletal System)    fully expand to see all 2 entries
             Cervical Sclerotome Cells Cervical Mesenchymal Sclerotome
             mesenchyme/trunk mesenchyme/paraxial mesenchyme   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Cervical Sclerotome Cells Cervical Mesenchymal Sclerotome
     
     Uterus (Reproductive System)    fully expand to see all 2 entries
             myometrium   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Cervical Sclerotome Cells Cervical Mesenchymal Sclerotome
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   

    See HOXD4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HOXD4

    SOURCE GeneReport for Unigene cluster: Hs.591609
        SABiosciences Expression via Pathway-Focused PCR Arrays including HOXD4: 
              Stem Cell Transcription Factors in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXD4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HOXD4 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hoxd41 , 5 homeobox D41, 5 90.36(n)1
    94.38(a)1
      2 (44.13 cM)5
    154361  NM_010469.21  NP_034599.21 
     747219785 
    chicken
    (Gallus gallus)
    Aves HOXD41 homeobox D4 77.64(n)
    76.79(a)
      424139  XM_421990.3  XP_421990.1 
    lizard
    (Anolis carolinensis)
    Reptilia HOXD46
    Uncharacterized protein
    73(a)
    1 ↔ 1
    GL343356.1(478136-480351)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3987442 HOXD4 77.16(n)    AY422086.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hoxd4a2 homeo box D4a 78.52(n)   30329  NM_130757.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Scr3 midgut development specific RNA
    polymerase II more
    71(a)
    (best of 2)
      3 84A5   --
    worm
    (Caenorhabditis elegans)
    Secernentea mab-56
    egl-56
    Homeobox protein egl-5
    28(a)
    18(a)
    many ↔ many
    many ↔ many
    III(7776907-7783454)
    III(7814382-7816451)


    ENSEMBL Gene Tree for HOXD4 (if available)
    TreeFam Gene Tree for HOXD4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HOXD4 gene
    GSX12  HOXA72  HOXA12  HOXB32  HOXD12  HOXA22  HOXB52  HOXC62  
    HOXC52  GSX22  HOXB42  HOXA52  HOXA42  HOXD32  HOXA62  HOXC82  
    HOXA32  HOXD82  HOXB62  HOXB12  HOXB82  HOXB22  PDX12  HOXB72  
    HOXC42  
    10 SIMAP similar genes for HOXD4 using alignment to 1 protein entry:     HXD4_HUMAN:
    HOXA4    HOXC6    HOXC4    HOXB4    HOXA5    HOXC5
    HOXB5    POU6F1    HOXA3    HOXA7

    HOXD4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/84 SNPs in HOXD4 are shown (see all 84)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1048936361,2
    Cother1176411472(+) ACAAGA/TGCCAG 2 E V mis10--------
    rs2007122441,2
    --176409050(+) CAGTT-/AAAAAA 1 -- us2k10--------
    rs1848497951,2
    --176409096(+) AAAAGC/TCCCAC 1 -- us2k10--------
    rs748491241,2
    C--176409434(+) AGGGC-/TGGCCATG 1 -- cds10--------
    rs1897401321,2
    --176409667(+) TTATTA/TTTCTT 1 -- us2k10--------
    rs1816953811,2
    --176409704(+) GAAGAA/CTATTC 1 -- us2k10--------
    rs1860367701,2
    --176409738(+) CCTGAC/TCCTGG 1 -- us2k10--------
    rs1471946331,2
    --176409744(+) CCTGGC/TAGAAG 1 -- us2k10--------
    rs18678631,2
    C,F,A,H--176409839(-) GCCACC/AACCGT 1 -- us2k115Minor allele frequency- A:0.32MN NA NS EA WA 1150
    rs2000156431,2
    C--176410008(+) AACTTC/TACGTT 1 -- us2k11Minor allele frequency- T:0.00EU 1301

    HapMap Linkage Disequilibrium report for HOXD4 (177015950 - 177017954 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for HOXD4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv875446CNV Loss21882294
    nsv875438CNV Loss21882294
    dgv676n67CNV Gain20364138


    Human Gene Mutation Database (HGMD): HOXD4
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 142981    OMIM disorders: --

    4 diseases for HOXD4:    About MalaCards
    clubfoot    neuroblastoma    thyroiditis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for HOXD4:
    Embryonal carcinoma

    HOXD4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): HOXD4
    Human Genome Epidemiology (HuGE) Navigator: HOXD4 (5 documents)

    Export disorders for HOXD4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HOXD4 gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with HOXD4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutation analysis of the HOX paralogous 4-13 genes in children with acute lymphoid malignancies: identification of a novel germline mutation of HOXD4 leading to a partial loss-of-function. (PubMed id 15776434)1, 4, 9 van Scherpenzeel Thim V....Verellen-Dumoulin C. (2005)
    2. Altered transmission of HOX and apoptotic SNPs identi fy a potential common pathway for clubfoot. (PubMed id 19938081)1, 4 Ester A.R....Hecht J.T. (2009)
    3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (1992)
    6. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (1990)
    7. Molecular mechanisms underlying the expression of the human HOX-5.1 gene. (PubMed id 1975093)1, 2 Cianetti L.... Peschle C. (1990)
    8. Organization of human class I homeobox genes. (PubMed id 2576652)1, 2 Boncinelli E.... Simeone A. (1989)
    9. Differential and stage-related expression in embryonic tissues of a new human homoeobox gene. (PubMed id 2879245)1, 2 Mavilio F.... Boncinelli E. (1986)
    10. PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins. (PubMed id 10523646)1, 9 Shanmugam K....Featherstone M.S. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3233 HGNC: 5138 AceView: HOXD4 Ensembl:ENSG00000170166 euGenes: HUgn3233
    ECgene: HOXD4 H-InvDB: HOXD4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HOXD4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HOXD4 gene:
    Search GeneIP for patents involving HOXD4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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