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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HOXD4 Gene

protein-coding   GIFtS: 56
GCID: GC02P177026

homeobox D4

(Previous name: homeo box D4 )
(Previous symbols: HOX4B, HOX4)
 Explore 8 diseases affiliated with
HOXD4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HOXD4    

Aliases
for HOXD4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Homeobox D41 2     Homeo Box D41
HOX4B1 2 3 5     HHO.C132
HOX41 2     HOX-5.12
Homeobox Protein HHO.C132 3     Hox-4.22
Homeobox Protein Hox-4B2 3     Homeobox Protein Hox-D42
Homeobox Protein Hox-5.12 3     Hox-4.2, Mouse, Homolog Of Homeo Box X2

External Ids:    HGNC: 51381   Entrez Gene: 32332   Ensembl: ENSG000001701667   OMIM: 1429815   UniProtKB: P090163   

Export aliases for HOXD4 gene to outside databases

Previous GC identifers: GC02P175067 GC02P175677 GC02P176980 GC02P177218 GC02P176841 GC02P176724 GC02P177016 GC02P168892 GC02P177019 GC02P177022


Summaries
for HOXD4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HOXD4:
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription
factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar
homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes
arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions
that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital
abnormalities. The protein encoded by this gene may play a role in determining positional values in developing limb
buds. Alternatively spliced variants have been described but their full length nature has not been determined.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HXD4_HUMAN, P09016
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXD4


Genomic Views
for HOXD4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HOXD4 gene promoter:
         HOXA9B   HOXA9   Nkx2-5   Gfi-1   c-Ets-1   HOXA5   COMP1   FOXO1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HOXD4 promoter sequence
   Search SABiosciences Chromatin IP Primers for HOXD4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOXD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

HOXD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXD4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P177026:  view genomic region     (about GC identifiers)

Start:
 177,015,950 bp from pter      End:
 177,020,802 bp from pter
Size:
 4,853 bases      Orientation:
 plus strand

Proteins
for HOXD4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HXD4_HUMAN, P09016 (See protein sequence)
Recommended Name: Homeobox protein Hox-D4  
Size: 255 amino acids; 27885 Da
Subcellular location: Nucleus
Secondary accessions: B2R9R3 Q96AU0

Explore the universe of human proteins at neXtProt for HOXD4: NX_P09016

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P09016

    • HOXD4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055436.2  
    ENSEMBL proteins: 
     ENSP00000302548  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: HOXD4
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    Novus Biologicals HOXD4 Proteins
    Novus Biologicals HOXD4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HOXD4

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--


    HOXD4 for ontologies           About GeneDecksing



    HOXD4 Antibody Products: 
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    Uscn Antibodies for HOXD4
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    Uscn ELISAs and CLIAs for HOXD4

    Protein Domains /
    Families
    for HOXD4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HOXD4 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR001827 Homeobox_Antennapedia_CS
     IPR020479 Homeobox_metazoa
     IPR017995 Homeobox_antennapedia
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain

    Graphical View of Domain Structure for InterPro Entry P09016

    ProtoNet protein and cluster: P09016

    1 Blocks protein family: IPB001827 Homeobox protein

    UniProtKB/Swiss-Prot: HXD4_HUMAN, P09016
    Similarity: Belongs to the Antp homeobox family. Deformed subfamily
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for HOXD4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HXD4_HUMAN, P09016
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
    with specific positional identities on the anterior-posterior axis

         Genatlas biochemistry entry for HOXD4:
    homeo box D4(4B),homologous to mouse Hox-4.2,Drosophila Dfd

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXD4
    1 QIAGEN miScript miRNA Assays for microRNA that regulate HOXD4:
    hsa-miR-222*
    SwitchGear 3'UTR luciferase reporter plasmid: HOXD4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXD4 (see all 7)
    OriGene shRNA RFP: HOXD4
    OriGene siRNA: HOXD4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXD4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HOXD4

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HOXD4 (see all 3)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXD4 

    Cell Line
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    Search LifeMap BioReagents cell lines for HOXD4

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXD4

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity NAS--
    GO:0043565sequence-specific DNA binding IEA--


    HOXD4 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for HOXD4:
     Decreased cell number 

    Animal Models:
         Mouse knock-out Hoxd4tm1Bhr for HOXD4
         5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Hoxd4):
     craniofacial  growth/size  mortality/aging  reproductive system  skeleton 

    HOXD4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HOXD4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HOXD4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/21 Interacting proteins for HOXD4 (P090163 ENSP000003025484) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ASB8Q9H7653, ENSP000003208934I2D: score=1 STRING: ENSP00000320893
    DEDDO756183, ENSP000003569854I2D: score=1 STRING: ENSP00000356985
    HOXB13Q928263, ENSP000002902954I2D: score=1 STRING: ENSP00000290295
    MEIS1O004703, ENSP000002723694I2D: score=1 STRING: ENSP00000272369
    XRCC6P129563, ENSP000003522574I2D: score=1 STRING: ENSP00000352257
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS--
    GO:0007275multicellular organismal development NAS2879245
    GO:0009952anterior/posterior pattern specification IEA--
    GO:0048704embryonic skeletal system morphogenesis IEA--


    HOXD4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HOXD4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HOXD4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HOXD4
    1 Novoseek chemical compound relationship for HOXD4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 30.6 2 7501971 (2)

    Search CenterWatch for drugs/clinical trials and news about HOXD4 / HXD4 

    Transcripts
    for HOXD4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HOXD4 gene: 
    NM_014621.2  

    Unigene Cluster for HOXD4:

    Homeobox D4
    Hs.591609  [show with all ESTs]
    Unigene Representative Sequence: X04706
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306324(uc002uks.3) ENST00000465649

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXD4
    1 QIAGEN miScript miRNA Assays for microRNA that regulate HOXD4:
    hsa-miR-222*
    SwitchGear 3'UTR luciferase reporter plasmid: HOXD4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXD4 (see all 7)
    OriGene shRNA RFP: HOXD4
    OriGene siRNA: HOXD4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXD4
    Clone
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    GenScript: all cDNA clones in your preferred vector: HOXD4 (NM_014621)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXD4 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HOXD4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXD4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXD4

    Additional cDNA sequence: 

    AK311735.1 AK313885.1 BC016763.1 BC074797.2 X04706.1 

    2 DOTS entries:

    DT.92419427  DT.120935783 

    24/53 AceView cDNA sequences (see all 53):

    AI913601 AI223819 AW168155 BF061514 BQ008052 BX102979 AW451394 AA447692 
    NM_014621 BC016763 AI168479 AI074140 BG677525 AI671371 AW452138 BE048811 
    BF061522 BC074797 AW299695 X04706 AA999852 BQ676986 BV200093 BX471755 

    GeneLoc Exon Structure


    Expression
    for HOXD4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HOXD4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGTTCGTATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HOXD4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    SomiteCervical Mesenchymal SclerotomeCervical Sclerotome CellsBone, Cartilage, Tendons & Ligaments
    LimbZeugopodPrechondrocytic Mesenchymal CellsBone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Primordial-like germ cells (cKIT+ SSEA1+ VASA+) (Derivation of primor...)

    See HOXD4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HOXD4

    SOURCE GeneReport for Unigene cluster: Hs.591609
        SABiosciences Expression via Pathway-Focused PCR Arrays including HOXD4: 
              Stem Cell Transcription Factors in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXD4

    Orthologs
    for HOXD4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for HOXD4 gene from 6/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves HOXD41 homeobox D4 77.64(n)
    76.79(a)    		   424139  XM_421990.3  XP_421990.1 
    lizard
    (Anolis carolinensis)    		 Reptilia HOXD46
    		 --
    		 73(a)
    		 possible ortholog
    		 GL343356.1(478136-480351)
    African clawed frog
    (Xenopus laevis)    		 Amphibia LOC3987442 HOXD4 77.16(n)    AY422086.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii hoxd4a2 homeo box D4a 78.52(n)   30329  NM_130757.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Scr3 midgut development specific RNA polymerase
    II more    		 71(a)
    (best of 2)    		   3 84A5   --
    worm
    (Caenorhabditis elegans)    		 Secernentea lin-396
    		 Homeobox protein lin-39
    		 22(a)
    		 possible ortholog
    		 III(7528603-7536567)


    ENSEMBL Gene Tree for HOXD4 (if available)
    TreeFam Gene Tree for HOXD4 (if available) 

    Paralogs
    for HOXD4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HOXD4 gene
    GSX12  HOXA72  HOXA12  HOXD12  HOXA22  HOXB32  HOXC62  HOXB52  
    GSX22  HOXC52  HOXB42  HOXA52  HOXA42  HOXD32  HOXA62  HOXC82  
    HOXA32  HOXD82  HOXB12  HOXB62  HOXB82  HOXB22  HOXB72  PDX12  
    HOXC42  
    12 SIMAP similar genes for HOXD4 using alignment to 1 protein entry:     HXD4_HUMAN:
    HOXA4    HOXC6    HOXC4    HOXB4    HOXA5    HOXC5
    HOXB5    POU6F1    HOXA3    HOXA7    HOXB7    PDX1

    HOXD4 for paralogs           About GeneDecksing



    Genomic Variants
    for HOXD4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/59 NCBI SNPs in HOXD4 are shown (see all 59)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1048936361,2
    		Cother168893451(+) ACAAGA/TGCCAG 2 E V mis10--------
    rs134180781,2
    		C,F,H,--168892663(+) GACGGC/TGGCCT 1 -- us2k121Minor allele frequency- T:0.21MN EA NS WA NA CSA 2700
    rs134180851,2
    		C,F,--168892677(+) TATGGC/AAGAAT 1 -- us2k19Minor allele frequency- A:0.15MN EA WA NA CSA 722
    rs134182881,2
    		C,F,H,--168892860(+) GCATTC/TAGCTG 1 -- us2k118Minor allele frequency- T:0.24NS EA WA NA CSA 2224
    rs168635721,2
    		C,H--168893142(+) AGTAGG/AAGGGC 1 -- ut51 ese33Minor allele frequency- A:0.00MN EA NS 528
    rs10636571,2
    		C,F,H,--168894719(+) GGGGGC/TGGGAT 1 -- ut31 ese311Minor allele frequency- T:0.08NS NA 1760
    rs791443931,2
    		C,F,--168895256(+) TCCACC/TCCTCC 1 -- ds50013Minor allele frequency- T:0.07CSA WA 122
    rs2007122441,2
    		--177014181(+) CAGTT-/AAAAAA 2 -- us2k10--------
    rs1848497951,2
    		--177014227(+) AAAAGC/TCCCAC 2 -- us2k10--------
    rs748491241,2
    		C--177014565(+) AGGGC-/TGGCCATG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for HOXD4 (177015950 - 177020802 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HOXD4: --
    Human Gene Mutation Database (HGMD): HOXD4

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HOXD4
    DNA2.0 Custom Variant and Variant Library Synthesis for HOXD4

    Disorders / Diseases
    for HOXD4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HOXD4 for disorders           About GeneDecksing

    OMIM gene information: 142981    OMIM disorders: --

    8 diseases for HOXD4:    About MalaCards
    synpolydactyly    clubfoot    embryonal carcinoma    leukemia
    breast cancer    neuroblastoma    thyroiditis    carcinoma

    1 disease from the University of Copenhagen DISEASES database for HOXD4:
    Embryonal carcinoma
    Genetic Association Database (GAD): HOXD4
    Human Genome Epidemiology (HuGE) Navigator: HOXD4 (5 documents)

    Export disorders for HOXD4 gene to outside databases

    Publications
    for HOXD4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HOXD4 gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with HOXD4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutation analysis of the HOX paralogous 4-13 genes in children with acute lymphoid malignancies: identification of a novel germline mutation of HOXD4 leading to a partial loss-of-function. (PubMed id 15776434)1, 4, 9 van Scherpenzeel Thim V....Verellen-Dumoulin C. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (1992)
    4. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (1990)
    5. Molecular mechanisms underlying the expression of the human HOX-5.1 gene. (PubMed id 1975093)1, 2 Cianetti L.... Peschle C. (1990)
    6. Organization of human class I homeobox genes. (PubMed id 2576652)1, 2 Boncinelli E.... Simeone A. (1989)
    7. Differential and stage-related expression in embryonic tissues of a new human homoeobox gene. (PubMed id 2879245)1, 2 Mavilio F.... Boncinelli E. (1986)
    8. PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins. (PubMed id 10523646)1, 9 Shanmugam K....Featherstone M.S. (1999)
    9. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
    10. Polymorphisms in the HOXD4 gene are not associated wi th peak bone mineral density in Chinese nuclear families. (PubMed id 20686522)1 Zhang H....Zhang Z.L. (2010)

    External Searches for HOXD4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing HOXD4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3233 HGNC: 5138 AceView: HOXD4 Ensembl:ENSG00000170166 euGenes: HUgn3233
    ECgene: HOXD4 H-InvDB: HOXD4

    Other Databases showing HOXD4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HOXD4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HOXD4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HOXD4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HOXD4 gene:
    Search GeneIP for patents involving HOXD4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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