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Aliases for HOXD4 Gene

Aliases for HOXD4 Gene

  • Homeobox D4 2 3
  • HOX4B 3 4 6
  • Homeobox Protein HHO.C13 3 4
  • Homeobox Protein Hox-5.1 3 4
  • Homeobox Protein Hox-4B 3 4
  • Hox-4.2, Mouse, Homolog Of Homeo Box X 3
  • Homeobox Protein Hox-D4 3
  • Homeo Box D4 2
  • HHO.C13 3
  • HOX-5.1 3
  • Hox-4.2 3
  • HOX4 3

External Ids for HOXD4 Gene

Previous HGNC Symbols for HOXD4 Gene

  • HOX4B
  • HOX4

Previous GeneCards Identifiers for HOXD4 Gene

  • GC02P175067
  • GC02P175677
  • GC02P176980
  • GC02P177218
  • GC02P176841
  • GC02P176724
  • GC02P177016
  • GC02P168892
  • GC02P177019
  • GC02P177022
  • GC02P177026
  • GC02P177030
  • GC02P177034

Summaries for HOXD4 Gene

Entrez Gene Summary for HOXD4 Gene

  • This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in determining positional values in developing limb buds. Alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXD4 Gene

HOXD4 (Homeobox D4) is a Protein Coding gene. Diseases associated with HOXD4 include synpolydactyly and clubfoot. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HOXA7.

UniProtKB/Swiss-Prot for HOXD4 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXD4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXD4 Gene

Genomics for HOXD4 Gene

Regulatory Elements for HOXD4 Gene

Genomic Location for HOXD4 Gene

Start:
176,150,394 bp from pter
End:
176,153,226 bp from pter
Size:
2,833 bases
Orientation:
Plus strand

Genomic View for HOXD4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HOXD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXD4 Gene

Proteins for HOXD4 Gene

  • Protein details for HOXD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09016-HXD4_HUMAN
    Recommended name:
    Homeobox protein Hox-D4
    Protein Accession:
    P09016
    Secondary Accessions:
    • B2R9R3
    • Q96AU0

    Protein attributes for HOXD4 Gene

    Size:
    255 amino acids
    Molecular mass:
    27885 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXD4 Gene

Proteomics data for HOXD4 Gene at MOPED

Post-translational modifications for HOXD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXD4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOXD4 Gene

Domains for HOXD4 Gene

Gene Families for HOXD4 Gene

HGNC:
  • HOXL :Homeoboxes / ANTP class : HOXL subclass

Suggested Antigen Peptide Sequences for HOXD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P09016

UniProtKB/Swiss-Prot:

HXD4_HUMAN :
  • P09016
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the Antp homeobox family. Deformed subfamily.
genes like me logo Genes that share domains with HOXD4: view

Function for HOXD4 Gene

Molecular function for HOXD4 Gene

GENATLAS Biochemistry: homeo box D4(4B),homologous to mouse Hox-4.2,Drosophila Dfd
UniProtKB/Swiss-Prot Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Gene Ontology (GO) - Molecular Function for HOXD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HOXD4: view

Phenotypes for HOXD4 Gene

genes like me logo Genes that share phenotypes with HOXD4: view

Animal Models for HOXD4 Gene

MGI Knock Outs for HOXD4:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for HOXD4 Gene

Localization for HOXD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXD4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOXD4 Gene COMPARTMENTS Subcellular localization image for HOXD4 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HOXD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with HOXD4: view

Pathways for HOXD4 Gene

SuperPathways for HOXD4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HOXD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organismal development NAS 2879245
genes like me logo Genes that share ontologies with HOXD4: view

No data available for Pathways by source for HOXD4 Gene

Compounds for HOXD4 Gene

(1) Novoseek inferred chemical compound relationships for HOXD4 Gene

Compound -log(P) Hits PubMed IDs
retinoic acid 30.6 2
genes like me logo Genes that share compounds with HOXD4: view

Transcripts for HOXD4 Gene

mRNA/cDNA for HOXD4 Gene

Unigene Clusters for HOXD4 Gene

Homeobox D4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HOXD4 Gene

No ASD Table

Relevant External Links for HOXD4 Gene

GeneLoc Exon Structure for
HOXD4
ECgene alternative splicing isoforms for
HOXD4

Expression for HOXD4 Gene

mRNA expression in normal human tissues for HOXD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for HOXD4 Gene Hs.591609

genes like me logo Genes that share expressions with HOXD4: view

No data available for mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for HOXD4 Gene

Orthologs for HOXD4 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOXD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOXD4 35
  • 99.74 (n)
  • 99.22 (a)
HOXD4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HOXD4 35
  • 89.28 (n)
  • 90.98 (a)
HOXD4 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HOXD4 35
  • 81.48 (n)
  • 82.08 (a)
HOXD4 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hoxd4 35
  • 87.6 (n)
  • 90 (a)
Hoxd4 16
oppossum
(Monodelphis domestica)
Mammalia HOXD4 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HOXD4 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hoxd4 35
  • 87.92 (n)
  • 90.84 (a)
chicken
(Gallus gallus)
Aves HOXD4 35
  • 75.95 (n)
  • 75.11 (a)
HOXD4 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HOXD4 36
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398744 35
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxd4 35
  • 68.36 (n)
  • 69.49 (a)
Str.15492 35
zebrafish
(Danio rerio)
Actinopterygii hoxd4a 35
  • 67.23 (n)
  • 65.25 (a)
hoxd4a 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Dfd 36
  • 18 (a)
OneToMany
Dfd 37
  • 70 (a)
Scr 37
  • 71 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToMany
Species with no ortholog for HOXD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXD4 Gene

ENSEMBL:
Gene Tree for HOXD4 (if available)
TreeFam:
Gene Tree for HOXD4 (if available)

Paralogs for HOXD4 Gene

Selected SIMAP similar genes for HOXD4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HOXD4: view

Variants for HOXD4 Gene

Sequence variations from dbSNP and Humsavar for HOXD4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
VAR_067445 -

Structural Variations from Database of Genomic Variants (DGV) for HOXD4 Gene

Variant ID Type Subtype PubMed ID
dgv676n67 CNV Gain 20364138
nsv875438 CNV Loss 21882294
nsv875446 CNV Loss 21882294

Relevant External Links for HOXD4 Gene

HapMap Linkage Disequilibrium report
HOXD4
Human Gene Mutation Database (HGMD)
HOXD4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXD4 Gene

Disorders for HOXD4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for HOXD4 Gene including...

Search for HOXD4 Gene in MalaCards »

(1) University of Copenhagen DISEASES for HOXD4 Gene

Relevant External Links for HOXD4

Genetic Association Database (GAD)
HOXD4
Human Genome Epidemiology (HuGE) Navigator
HOXD4
genes like me logo Genes that share disorders with HOXD4: view

No data available for UniProtKB/Swiss-Prot for HOXD4 Gene

Publications for HOXD4 Gene

  1. Mutation analysis of the HOX paralogous 4-13 genes in children with acute lymphoid malignancies: identification of a novel germline mutation of HOXD4 leading to a partial loss-of-function. (PMID: 15776434) van Scherpenzeel Thim V. … Verellen-Dumoulin C. (Hum. Mutat. 2005) 3 23 48
  2. Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott M.P. (Cell 1992) 2 3
  3. Nomenclature for human homeobox genes. (PMID: 1973146) McAlpine P.J. … Shows T.B. (Genomics 1990) 2 3
  4. Molecular mechanisms underlying the expression of the human HOX-5.1 gene. (PMID: 1975093) Cianetti L. … Peschle C. (Nucleic Acids Res. 1990) 3 4
  5. Organization of human class I homeobox genes. (PMID: 2576652) Boncinelli E. … Simeone A. (Genome 1989) 3 4

Products for HOXD4 Gene

Sources for HOXD4 Gene

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