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Aliases for HOXD3 Gene

Aliases for HOXD3 Gene

  • Homeobox D3 2 3
  • HOX4A 3 4 6
  • Homeobox Protein Hox-4A 3 4
  • Homeo Box D3 2 3
  • HOX1D 3 4
  • Hox-4.1, Mouse, Homolog Of 3
  • Homeobox Protein Hox-D3 3
  • Hox-4.1 3
  • HOX4 3

External Ids for HOXD3 Gene

Previous HGNC Symbols for HOXD3 Gene

  • HOX4A
  • HOX4
  • HOX1D

Previous GeneCards Identifiers for HOXD3 Gene

  • GC02P175081
  • GC02P175689
  • GC02P176992
  • GC02P177231
  • GC02P176854
  • GC02P176737
  • GC02P177001
  • GC02P168905

Summaries for HOXD3 Gene

Entrez Gene Summary for HOXD3 Gene

  • This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in the regulation of cell adhesion processes. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXD3 Gene

HOXD3 (Homeobox D3) is a Protein Coding gene. Diseases associated with HOXD3 include duane retraction syndrome and vacterl association. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is EVX1.

UniProtKB/Swiss-Prot for HOXD3 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXD3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXD3 Gene

Genomics for HOXD3 Gene

Regulatory Elements for HOXD3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HOXD3 Gene

Start:
176,136,612 bp from pter
End:
176,173,102 bp from pter
Size:
36,491 bases
Orientation:
Plus strand

Genomic View for HOXD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HOXD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXD3 Gene

Proteins for HOXD3 Gene

  • Protein details for HOXD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31249-HXD3_HUMAN
    Recommended name:
    Homeobox protein Hox-D3
    Protein Accession:
    P31249
    Secondary Accessions:
    • Q99955
    • Q9BSC5

    Protein attributes for HOXD3 Gene

    Size:
    432 amino acids
    Molecular mass:
    45730 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA01891.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for HOXD3 Gene

Proteomics data for HOXD3 Gene at MOPED

Post-translational modifications for HOXD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXD3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOXD3 Gene

Domains for HOXD3 Gene

Gene Families for HOXD3 Gene

HGNC:
  • HOXL :Homeoboxes / ANTP class : HOXL subclass

Suggested Antigen Peptide Sequences for HOXD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P31249

UniProtKB/Swiss-Prot:

HXD3_HUMAN :
  • P31249
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the Antp homeobox family.
genes like me logo Genes that share domains with HOXD3: view

Function for HOXD3 Gene

Molecular function for HOXD3 Gene

GENATLAS Biochemistry: homeo box D3(4A),homologous to mouse Hox-4.1,Drosophila Zen
UniProtKB/Swiss-Prot Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Gene Ontology (GO) - Molecular Function for HOXD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 23088713
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HOXD3: view
genes like me logo Genes that share phenotypes with HOXD3: view

Animal Models for HOXD3 Gene

MGI Knock Outs for HOXD3:

Animal Model Products

CRISPR Products

miRNA for HOXD3 Gene

miRTarBase miRNAs that target HOXD3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HOXD3 Gene

Localization for HOXD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXD3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOXD3 Gene COMPARTMENTS Subcellular localization image for HOXD3 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for HOXD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IC 12836255
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with HOXD3: view

Pathways for HOXD3 Gene

SuperPathways for HOXD3 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for HOXD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IMP 12836255
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007160 cell-matrix adhesion IDA 7742539
GO:0007219 Notch signaling pathway IMP 12836255
GO:0009952 anterior/posterior pattern specification ISS --
genes like me logo Genes that share ontologies with HOXD3: view

No data available for Pathways by source for HOXD3 Gene

Transcripts for HOXD3 Gene

Unigene Clusters for HOXD3 Gene

Homeobox D3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HOXD3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOXD3 Gene

No ASD Table

Relevant External Links for HOXD3 Gene

GeneLoc Exon Structure for
HOXD3
ECgene alternative splicing isoforms for
HOXD3

Expression for HOXD3 Gene

mRNA expression in normal human tissues for HOXD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXD3 Gene

This gene is overexpressed in Uterus (6.8), Kidney - Cortex (5.7), and Ovary (4.4).

SOURCE GeneReport for Unigene cluster for HOXD3 Gene Hs.93574

genes like me logo Genes that share expressions with HOXD3: view

In Situ Assay Products

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for HOXD3 Gene

Orthologs for HOXD3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HOXD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOXD3 35
  • 97.92 (n)
  • 97.67 (a)
HOXD3 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HOXD3 35
  • 91.98 (n)
  • 95.37 (a)
HOXD3 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HOXD3 35
  • 92.73 (n)
  • 97.45 (a)
HOXD3 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hoxd3 35
  • 90.12 (n)
  • 94.68 (a)
Hoxd3 16
Hoxd3 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HOXD3 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hoxd3 35
  • 90.9 (n)
  • 96.76 (a)
chicken
(Gallus gallus)
Aves HOXD3 35
  • 76.38 (n)
  • 77.91 (a)
HOXD3 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HOXD3 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxd3 35
  • 68.61 (n)
  • 69.83 (a)
zebrafish
(Danio rerio)
Actinopterygii hoxd3a 35
  • 65.74 (n)
  • 68.61 (a)
hoxd3a 36
  • 69 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 17 (a)
OneToMany
Species with no ortholog for HOXD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXD3 Gene

ENSEMBL:
Gene Tree for HOXD3 (if available)
TreeFam:
Gene Tree for HOXD3 (if available)

Paralogs for HOXD3 Gene

Paralogs for HOXD3 Gene

Selected SIMAP similar genes for HOXD3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HOXD3: view

Variants for HOXD3 Gene

Sequence variations from dbSNP and Humsavar for HOXD3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs711830 -- 176,172,583(-) GCCGC(A/C/G/T)GATGG utr-variant-3-prime
rs717852 -- 176,166,895(-) TACCA(A/G)AATGA intron-variant
rs728521 -- 176,166,955(-) TCATC(A/G)TGATG intron-variant
rs1005440 -- 176,156,671(-) TTGCC(C/T)GAGGG intron-variant, upstream-variant-2KB
rs1051927 -- 176,172,533(+) GACCA(A/T)GGGAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HOXD3 Gene

Variant ID Type Subtype PubMed ID
dgv676n67 CNV Gain 20364138
nsv875438 CNV Loss 21882294

Relevant External Links for HOXD3 Gene

HapMap Linkage Disequilibrium report
HOXD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXD3 Gene

Disorders for HOXD3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for HOXD3 Gene including...

Search for HOXD3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for HOXD3 Gene

Relevant External Links for HOXD3

Genetic Association Database (GAD)
HOXD3
Human Genome Epidemiology (HuGE) Navigator
HOXD3
genes like me logo Genes that share disorders with HOXD3: view

No data available for UniProtKB/Swiss-Prot for HOXD3 Gene

Publications for HOXD3 Gene

  1. Organization of human class I homeobox genes. (PMID: 2576652) Boncinelli E. … Simeone A. (Genome 1989) 3 4
  2. Overexpression of the HOX4A (HOXD3) homeobox gene in human erythroleukemia HEL cells results in altered adhesive properties. (PMID: 7742539) Taniguchi Y. … Moriuchi T. (Blood 1995) 3 23
  3. Cloning and sequencing of the human homeobox gene HOX4A. (PMID: 1358204) Taniguchi Y. … Moriuchi T. (Biochim. Biophys. Acta 1992) 3 4
  4. Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott M.P. (Cell 1992) 2 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for HOXD3 Gene

Sources for HOXD3 Gene

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