Aliases for HOXD3 Gene
Aliases for HOXD3 Gene
External Ids for HOXD3 Gene
- HGNC: 5137
- Entrez Gene: 3232
- Ensembl: ENSG00000128652
- OMIM: 142980
- UniProtKB: P31249
Previous HGNC Symbols for HOXD3 Gene
- HOX4A
- HOX4
- HOX1D
Previous GeneCards Identifiers for HOXD3 Gene
- GC02P175081
- GC02P175689
- GC02P176992
- GC02P177231
- GC02P176854
- GC02P176737
- GC02P177001
- GC02P168905
Summaries for HOXD3 Gene
-
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in the regulation of cell adhesion processes. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOXD3 Gene
HOXD3 (Homeobox D3) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Developmental Biology. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is HOXB3.
UniProtKB/Swiss-Prot for HOXD3 Gene
-
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXD3 Gene
Genomics for HOXD3 Gene
Regulatory Elements for HOXD3 Gene
Regulatory Element Products
Genomic Location for HOXD3 Gene
- Chromosome:
- 2
- Start:
- 176,136,612 bp from pter
- End:
- 176,173,102 bp from pter
- Size:
- 36,491 bases
- Orientation:
- Plus strand
Genomic View for HOXD3 Gene
- Cytogenetic band:
-
- 2q31.1 by Ensembl
- 2q31.1 by Entrez Gene
- 2q31.1 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HOXD3 Gene
Proteins for HOXD3 Gene
-
Protein details for HOXD3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P31249-HXD3_HUMAN
- Recommended name:
- Homeobox protein Hox-D3
- Protein Accession:
- P31249
- Q99955
- Q9BSC5
Protein attributes for HOXD3 Gene
- Size:
- 432 amino acids
- Molecular mass:
- 45730 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAA01891.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Post-translational modifications for HOXD3 Gene
Other Protein References for HOXD3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HOXD3
- Invitrogen Antibodies for HOXD3
- antibodies-online Antibodies for HOXD3: See all 39
- GeneTex HOXD3 antibody for HOXD3
- GeneTex Tlr3 antibody for HOXD3
-
Santa Cruz Biotechnology (SCBT) Antibodies for HOXD3
Protein Products
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- Novus Biologicals proteins for HOXD3
- antibodies-online Proteins for HOXD3: See all 9
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HOXD3
Assay Products
No data available for DME Specific Peptides for HOXD3 Gene
Domains & Families for HOXD3 Gene
Gene Families for HOXD3 Gene
Protein Domains for HOXD3 Gene
Suggested Antigen Peptide Sequences for HOXD3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P31249- Family:
-
- Belongs to the Antp homeobox family.
Function for HOXD3 Gene
Molecular function for HOXD3 Gene
- GENATLAS Biochemistry:
- homeo box D3(4A),homologous to mouse Hox-4.1,Drosophila Zen
- UniProtKB/Swiss-Prot Function:
- Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 23088713 |
| GO:0043565 | sequence-specific DNA binding | IEA | -- |
Phenotypes for HOXD3 Gene
- MGI mutant phenotypes for HOXD3:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for HOXD3:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXD3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXD3 gene
- Search ViGene Biosciences for HOXD3
CRISPR Products
-
OriGene CRISPR knockouts for HOXD3
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXD3
- GenScript: Design CRISPR guide RNA sequences for HOXD3
miRNA for HOXD3 Gene
- miRTarBase miRNAs that target HOXD3
-
- hsa-mir-17-3p (MIRT050780)
- hsa-mir-4467 (MIRT484653)
- hsa-mir-4763-3p (MIRT484654)
- hsa-mir-1207-5p (MIRT484655)
- hsa-mir-8072 (MIRT484656)
- hsa-mir-31-5p (MIRT484657)
- hsa-mir-3960 (MIRT484658)
- hsa-mir-6820-5p (MIRT484659)
- hsa-mir-6836-5p (MIRT484660)
- hsa-mir-6132 (MIRT484661)
- hsa-mir-6087 (MIRT484662)
- hsa-mir-769-5p (MIRT484663)
- hsa-mir-4786-5p (MIRT484664)
- hsa-mir-4329 (MIRT484665)
- hsa-mir-4324 (MIRT484666)
- hsa-mir-1247-3p (MIRT484667)
- hsa-mir-335-5p (MIRT484668)
miRNA Products
- Search ViGene Biosciences for HOXD3
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HOXD3
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-
ViGene Biosciences ready-to-package AAV shRNAs for HOXD3 gene
Clone Products
-
OriGene ORF clones in human for HOXD3
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Cell Line Products
-
Horizon Cell Lines for HOXD3
-
ViGene Biosciences adenoviral particle packaged cDNA for HOXD3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXD3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXD3 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXD3 Gene
Localization for HOXD3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HOXD3 Gene
- Nucleus.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IC | 12836255 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0016235 | aggresome | IDA | -- |
| GO:0016604 | nuclear body | IDA | -- |
Pathways & Interactions for HOXD3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||
| 2 | Developmental Biology | ||
Pathways by source for HOXD3 Gene
Interacting Proteins for HOXD3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IMP | 12836255 |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0007160 | cell-matrix adhesion | IDA | 7742539 |
| GO:0007219 | Notch signaling pathway | IMP | 12836255 |
| GO:0007275 | multicellular organism development | IEA | -- |
No data available for SIGNOR curated interactions for HOXD3 Gene
Transcripts for HOXD3 Gene
mRNA/cDNA for HOXD3 Gene
- (8) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (28) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HOXD3
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXD3
- GenScript: Design CRISPR guide RNA sequences for HOXD3
miRNA Products
- Search ViGene Biosciences for HOXD3
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HOXD3
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-
ViGene Biosciences ready-to-package AAV shRNAs for HOXD3 gene
Clone Products
-
OriGene ORF clones in human for HOXD3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for HOXD3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Gut Tube (Gastrointestinal Tract)
-
Head Mesenchyme (Muscoskeletal System)
- Cardiac Neural Crest Cells Branchial Arch 3,4,6
-
Neural Crest (Gastrulation Derivatives)
- Cardiac Neural Crest Cells Branchial Arch 3,4,6
-
Somite (Muscoskeletal System)
- Sclerotome Cells Cervical Mesenchymal Sclerotome
-
Bone (Muscoskeletal System)
- Sclerotome Cells Cervical Mesenchymal Sclerotome
-
Cartilage (Muscoskeletal System)
- Sclerotome Cells Cervical Mesenchymal Sclerotome
-
Tendon amp Ligament
- Sclerotome Cells Cervical Mesenchymal Sclerotome
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Angioblasts Proepicardium
-
Endothelium (Cardiovascular System)
- Angioblasts Proepicardium
-
Kidney (Urinary System)
mRNA differential expression in normal tissues according to GTEx for HOXD3 Gene
NURSA nuclear receptor signaling pathways regulating expression of HOXD3 Gene:
HOXD3SOURCE GeneReport for Unigene cluster for HOXD3 Gene:
Hs.93574Evidence on tissue expression from TISSUES for HOXD3 Gene
- Lung(4.2)
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs for HOXD3
-
OriGene qPCR primer pairs and template standards for HOXD3
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXD3 Gene
Orthologs for HOXD3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HOXD3 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HOXD3 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HOXD3 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hoxd3 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Hoxd3 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | HOXD3 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HOXD3 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HOXD3 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hoxd3 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hoxd3a 34 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for HOXD3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HOXD3 Gene
Paralogs for HOXD3 Gene
(4) SIMAP similar genes for HOXD3 Gene using alignment to 3 proteins:
Variants for HOXD3 Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs104893636 | Uncertain significance | 176,151,875(+) | ACAAG(A/C/T)GCCAG | intron-variant, reference, missense | |
| rs1000017558 | -- | 176,145,327(+) | ACAGC(A/G)GCAGT | intron-variant | |
| rs1000060384 | -- | 176,143,027(+) | CTCCT(A/T)GTACT | intron-variant | |
| rs1000159751 | -- | 176,157,150(+) | CCGCG(C/T)CGGGC | intron-variant, upstream-variant-2KB | |
| rs1000251570 | -- | 176,170,273(+) | CATAA(A/C)CATGA | intron-variant |
Relevant External Links for HOXD3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HOXD3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXD3 Gene
Disorders for HOXD3 Gene
Relevant External Links for HOXD3
No disorders were found for HOXD3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOXD3 Gene
Publications for HOXD3 Gene
- A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. (PMID: 20852632) Goode E.L. … Pharoah P.D. (Nat. Genet. 2010) 3 46 64
- High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 46 64
- Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot. (PMID: 19938081) Ester A.R. … Hecht J.T. (Am. J. Med. Genet. A 2009) 3 46 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Overexpression of the HOX4A (HOXD3) homeobox gene in human erythroleukemia HEL cells results in altered adhesive properties. (PMID: 7742539) Taniguchi Y. … Moriuchi T. (Blood 1995) 3 22 64
Products for HOXD3 Gene
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- OriGene qPCR primer pairs and template standards for HOXD3
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- Novus Biologicals Antibodies for HOXD3
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- antibodies-online Antibodies for HOXD3: See all 39
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- antibodies-online Proteins for HOXD3: See all 9
- Search antibodies-online for peptides
- GeneTex HOXD3 antibody for HOXD3
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- ViGene Biosciences adenoviral particle packaged cDNA for HOXD3 gene
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HOXD3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
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- (122) diseasecard
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- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




