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HOXD3 Gene

protein-coding   GIFtS: 55
GCID: GC02P177001

Homeobox D3

(Previous name: homeo box D3)
(Previous symbols: HOX4A, HOX4, HOX1D)
  See HOXD3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Homeobox D31 2     Homeobox Protein Hox-4A2 3
HOX4A1 2 3 5     Hox-4.12
HOX1D1 2 3     Homeobox Protein Hox-D32
HOX41 2     Hox-4.1, Mouse, Homolog Of2
Homeo Box D31 2     

External Ids:    HGNC: 51371   Entrez Gene: 32322   Ensembl: ENSG000001286527   OMIM: 1429805   UniProtKB: P312493   

Export aliases for HOXD3 gene to outside databases

Previous GC identifers: GC02P175081 GC02P175689 GC02P176992 GC02P177231 GC02P176854 GC02P176737 GC02P168905


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HOXD3 Gene:
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of
transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals
possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes,
consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at
2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have
been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in
the regulation of cell adhesion processes. (provided by RefSeq, Jul 2008)

GeneCards Summary for HOXD3 Gene:
HOXD3 (homeobox D3) is a protein-coding gene. Diseases associated with HOXD3 include duane retraction syndrome, and vacterl association. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is GSX1.

UniProtKB/Swiss-Prot: HXD3_HUMAN, P31249
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXD3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HOXD3 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-2   c-Ets-1   E2F   E2F-1   COMP1   HOXA5   FOXO1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHOXD3 promoter sequence
   Search Chromatin IP Primers for HOXD3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HOXD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

HOXD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXD3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P177001:  view genomic region     (about GC identifiers)

Start:
177,001,340 bp from pter      End:
177,037,830 bp from pter
Size:
36,491 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HXD3_HUMAN, P31249 (See protein sequence)
Recommended Name: Homeobox protein Hox-D3  
Size: 432 amino acids; 45730 Da
Caution: It is uncertain whether Met-1 or Met-17 is the initiator
Sequence caution: Sequence=BAA01891.1; Type=Erroneous initiation;
Secondary accessions: Q99955 Q9BSC5

Explore the universe of human proteins at neXtProt for HOXD3: NX_P31249

Explore proteomics data for HOXD3 at MOPED


See HOXD3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_008829.3  
ENSEMBL proteins: 
 ENSP00000392615   ENSP00000424734   ENSP00000386498   ENSP00000249440  

HOXD3 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
HOXL: Homeoboxes / ANTP class : HOXL subclass

Selected InterPro protein domains (see all 6):
 IPR001827 Homeobox_Antennapedia_CS
 IPR020479 Homeobox_metazoa
 IPR017970 Homeobox_CS
 IPR001356 Homeobox_dom
 IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry P31249

ProtoNet protein and cluster: P31249

2 Blocks protein domains:
IPB000047 Lambda and other repressor helix-turn-helix signature
IPB001827 Homeobox protein


UniProtKB/Swiss-Prot: HXD3_HUMAN, P31249
Similarity: Belongs to the Antp homeobox family
Similarity: Contains 1 homeobox DNA-binding domain


Find genes that share domains with HOXD3           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: HXD3_HUMAN, P31249
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
cells with specific positional identities on the anterior-posterior axis

     Genatlas biochemistry entry for HOXD3:
homeo box D3(4A),homologous to mouse Hox-4.1,Drosophila Zen

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding ----
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
GO:0005515protein binding IPI--
GO:0043565sequence-specific DNA binding IEA--
     
Find genes that share ontologies with HOXD3           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for HOXD3:
 Decreased Wnt reporter activit 

     11 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Hoxd3):
 cardiovascular system  cellular  craniofacial  embryogenesis  endocrine/exocrine gland 
 hematopoietic system  immune system  mortality/aging  nervous system  respiratory system 
 skeleton 

Find genes that share phenotypes with HOXD3           About GenesLikeMe

Animal Models:
     MGI mouse knock-outs for HOXD3: Hoxd3tm2Mrc Hoxd3tm1Mrc

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HOXD3
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HOXD3

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HOXD3
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HOXD3

miRNA
Products:
    
miRTarBase miRNAs that target HOXD3:
hsa-mir-17-3p (MIRT050780)

Block miRNA regulation of human, mouse, rat HOXD3 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate HOXD3 (see all 9):
hsa-miR-21* hsa-miR-3671 hsa-miR-1226 hsa-miR-1283 hsa-miR-548o hsa-miR-500a hsa-miR-606 hsa-miR-466
SwitchGear 3'UTR luciferase reporter plasmidHOXD3 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for HOXD3
Predesigned siRNA for gene silencing in human, mouse, rat HOXD3

Gene Editing
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Clone
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OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: HOXD3 (NM_006898)
Sino Biological Human cDNA Clone for HOXD3
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXD3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXD3

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXD3


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
HXD3_HUMAN, P31249: Nucleus
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
cytosol2
extracellular1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IC12836255

Find genes that share ontologies with HOXD3           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Pathway & Disease-focused RT2 Profiler PCR Array including HOXD3: 
          Homeobox (HOX) Genes in human mouse rat

Interactions:

    GeneGlobe Interaction Network for HOXD3

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

Selected Interacting proteins for HOXD3 (P312491, 3 ENSP000002494404) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
InteractantInteraction Details
GeneCardExternal ID(s)
ALX4Q9H1613, ENSP000003327444I2D: score=1 STRING: ENSP00000332744
CERS2Q96G233, ENSP000002716884I2D: score=1 STRING: ENSP00000271688
MEOX2P502223, ENSP000002620414I2D: score=1 STRING: ENSP00000262041
HMGB1P094293, ENSP000003430404I2D: score=1 STRING: ENSP00000343040
DDB1Q165313, ENSP000003017644I2D: score=1 STRING: ENSP00000301764
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Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated IMP12836255
GO:0006355regulation of transcription, DNA-templated ----
GO:0007160cell-matrix adhesion IDA7742539
GO:0007219Notch signaling pathway IMP12836255
GO:0009952anterior/posterior pattern specification ISS--

Find genes that share ontologies with HOXD3           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for HOXD3 (HXD3)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for HOXD3 gene: 
NM_006898.4  

Unigene Cluster for HOXD3:

Homeobox D3
Hs.93574  [show with all ESTs]
Unigene Representative Sequence: BC005124
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000459979(uc002ukr.3) ENST00000432796 ENST00000468418 ENST00000410016
ENST00000249440(uc002ukt.1)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat HOXD3 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate HOXD3 (see all 9):
hsa-miR-21* hsa-miR-3671 hsa-miR-1226 hsa-miR-1283 hsa-miR-548o hsa-miR-500a hsa-miR-606 hsa-miR-466
SwitchGear 3'UTR luciferase reporter plasmidHOXD3 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for HOXD3
Predesigned siRNA for gene silencing in human, mouse, rat HOXD3
Clone
Products:
     
OriGene clones in human, mouse for HOXD3 (see all 7)
OriGene ORF clones in mouse, rat for HOXD3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: HOXD3 (NM_006898)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXD3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXD3
Primer
Products:
    
OriGene qPCR primer pairs and template standards for HOXD3
OriGene qSTAR qPCR primer pairs in human, mouse for HOXD3
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HOXD3
  QuantiTect SYBR Green Assays in human, mouse, rat HOXD3
  QuantiFast Probe-based Assays in human, mouse, rat HOXD3

Additional mRNA sequence: 

BC005124.2 BC008789.2 

2 DOTS entries:

DT.75105776  DT.99968895 

Selected AceView cDNA sequences (see all 28):

BF739816 NM_006898 AI373293 AW300138 BE348261 BE463473 BC005124 AI478225 
AI769665 BF114998 BC008789 BC047605 AI373320 AI911593 AW137579 AI955470 
AW271503 AI927335 AI223210 AW138896 BE797724 AA434183 BM543946 AI521702 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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HOXD3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGTAGAGTCA
HOXD3 Expression
About this image


HOXD3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 12) fully expand
 
 Tendon & Ligament
         Cervical Sclerotome Cells Cervical Mesenchymal Sclerotome
 
 Bone (Muscoskeletal System)
         Cervical Sclerotome Cells Cervical Mesenchymal Sclerotome
 
 Cartilage (Muscoskeletal System)
         Cervical Sclerotome Cells Cervical Mesenchymal Sclerotome
 
 Somite (Muscoskeletal System)
         Cervical Sclerotome Cells Cervical Mesenchymal Sclerotome
 
 Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
         Hindgut
HOXD3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

HOXD3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.93574
    Pathway & Disease-focused RT2 Profiler PCR Array including HOXD3: 
          Homeobox (HOX) Genes in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for HOXD3
OriGene qSTAR qPCR primer pairs in human, mouse for HOXD3
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HOXD3
QuantiTect SYBR Green Assays in human, mouse, rat HOXD3
QuantiFast Probe-based Assays in human, mouse, rat HOXD3
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXD3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for HOXD3 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Hoxd31 , 5 homeobox D31, 5 90.12(n)1
94.68(a)1
  2 (44.13 cM)5
154341  NM_010468.21  NP_034598.21 
 747119295 
chicken
(Gallus gallus)
Aves HOXD31 homeobox D3 76.38(n)
77.91(a)
  431212  XM_428765.4  XP_428765.2 
lizard
(Anolis carolinensis)
Reptilia HOXD36
homeobox D3
73(a)
1 ↔ 1
GL343356.1(402731-409310)
tropical clawed frog
(Xenopus tropicalis)
Amphibia hoxd31 homeobox D3 68.61(n)
69.83(a)
  100038058  XM_004917729.1  XP_004917786.1 
zebrafish
(Danio rerio)
Actinopterygii hoxd3a1 homeo box D3a 65.74(n)
68.61(a)
  30349  NM_131125.1  NP_571200.1 


ENSEMBL Gene Tree for HOXD3 (if available)
TreeFam Gene Tree for HOXD3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for HOXD3 gene
GSX12  HOXA32  MEOX12  EVX22  HOXA12  HOXB12  HOXB32  HOXD12  
HOXA22  GSX22  EVX12  HOXB22  MEOX22  PDX12  
4 SIMAP similar genes for HOXD3 using alignment to 3 protein entries:     HXD3_HUMAN (see all proteins):
HOXA3    HOXB3    HOXD8    HOXB6

Find genes that share paralogs with HOXD3           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for HOXD3 (see all 218)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs567612171,2
C--168909284(+) TTTTT-/TTTTTTT/TTTT
TTTT
/TTTTTTTTTT
AAGTT
1 -- int11NA 2
rs9668011,2
C,F,A,H--176432703(+) CAGTCA/GGAACT 1 -- ut3114Minor allele frequency- G:0.42MN NA WA CSA EA 565
rs1453307141,2
--177026810(+) GGTTGC/GGACAG 1 -- us2k10--------
rs1852212371,2
--177026837(+) AACCGA/CCTTCC 1 -- us2k10--------
rs1905463711,2
--177026933(+) ATTTTC/TCTTTG 1 -- us2k10--------
rs1141187991,2
--177027022(+) ATGGAA/GCATTC 1 -- us2k10--------
rs1823744731,2
--177027049(+) GAAAAC/TTTCAA 1 -- us2k10--------
rs1476726231,2
C--177027065(+) CCTACC/TAAGGC 1 -- us2k10--------
rs347204561,2
C,F--177027292(+) GACCCG/ACGTGG 1 -- us2k16Minor allele frequency- A:0.19NA CSA WA EA 366
rs126200321,2
C,H--177027833(+) GCCCTA/TCCGGG 1 -- us2k10--------

HapMap Linkage Disequilibrium report for HOXD3 (177001340 - 177037830 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for HOXD3:    About this table    
Variant IDTypeSubtypePubMed ID
nsv875438CNV Loss21882294
dgv676n67CNV Gain20364138

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing HOXD3
DNA2.0 Custom Variant and Variant Library Synthesis for HOXD3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 142980    OMIM disorders: --

2 diseases for HOXD3:    
About MalaCards
duane retraction syndrome    vacterl association

1 disease from the University of Copenhagen DISEASES database for HOXD3:
VACTERL association

Find genes that share disorders with HOXD3           About GenesLikeMe

Genetic Association Database (GAD): HOXD3
Human Genome Epidemiology (HuGE) Navigator: HOXD3 (3 documents)

Export disorders for HOXD3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for HOXD3 gene, integrated from 10 sources (see all 35):
(articles sorted by number of sources associating them with HOXD3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. (PubMed id 20852632)1, 4 Goode E.L....Pharoah P.D. (Nat. Genet. 2010)
  2. Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot. (PubMed id 19938081)1, 4 Ester A.R....Hecht J.T. (Am. J. Med. Genet. A 2009)
  3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (Cell 1992)
  6. Cloning and sequencing of the human homeobox gene HOX4A. (PubMed id 1358204)1, 2 Taniguchi Y.... Moriuchi T. (Biochim. Biophys. Acta 1992)
  7. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (Genomics 1990)
  8. Organization of human class I homeobox genes. (PubMed id 2576652)1, 2 Boncinelli E.... Simeone A. (Genome 1989)
  9. Overexpression of the HOX4A (HOXD3) homeobox gene in human erythroleukemia HEL cells results in altered adhesive properties. (PubMed id 7742539)1, 9 Taniguchi Y....Moriuchi T. (Blood 1995)
  10. Expression of HOXD3 correlates with shorter survival in patients with invasive breast cancer. (PubMed id 22935821)1 Shaoqiang C....Qingyuan Z. (amp 2013)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3232 HGNC: 5137 AceView: HOXD3 Ensembl:ENSG00000128652 euGenes: HUgn3232
ECgene: HOXD3 H-InvDB: HOXD3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for HOXD3 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for HOXD3 gene:
Search GeneIP for patents involving HOXD3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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