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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HOXD3 Gene

protein-coding   GIFtS: 56
GCID: GC02P177001

Homeobox D3

(Previous name: homeo box D3)
(Previous symbols: HOX4A, HOX4, HOX1D)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Homeobox D31 2     Homeobox Protein Hox-4A2 3
HOX4A1 2 3 5     Hox-4.12
HOX1D1 2 3     Homeobox Protein Hox-D32
HOX41 2     Hox-4.1, Mouse, Homolog Of2
Homeo Box D31 2     

External Ids:    HGNC: 51371   Entrez Gene: 32322   Ensembl: ENSG000001286527   OMIM: 1429805   UniProtKB: P312493   

Export aliases for HOXD3 gene to outside databases

Previous GC identifers: GC02P175081 GC02P175689 GC02P176992 GC02P177231 GC02P176854 GC02P176737 GC02P168905


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HOXD3 Gene:
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of
transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals
possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes,
consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at
2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have
been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in
the regulation of cell adhesion processes. (provided by RefSeq, Jul 2008)

GeneCards Summary for HOXD3 Gene: 
HOXD3 (homeobox D3) is a protein-coding gene. Diseases associated with HOXD3 include duane retraction syndrome, and vacterl association. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is GSX1.

UniProtKB/Swiss-Prot: HXD3_HUMAN, P31249
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXD3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HOXD3 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-2   c-Ets-1   E2F   E2F-1   COMP1   HOXA5   FOXO1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHOXD3 promoter sequence
   Search SABiosciences Chromatin IP Primers for HOXD3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOXD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

HOXD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXD3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P177001:  view genomic region     (about GC identifiers)

Start:
177,001,340 bp from pter      End:
177,037,830 bp from pter
Size:
36,491 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HXD3_HUMAN, P31249 (See protein sequence)
Recommended Name: Homeobox protein Hox-D3  
Size: 432 amino acids; 45730 Da
Subcellular location: Nucleus
Caution: It is uncertain whether Met-1 or Met-17 is the initiator
Sequence caution: Sequence=BAA01891.1; Type=Erroneous initiation;
Secondary accessions: Q99955 Q9BSC5

Explore the universe of human proteins at neXtProt for HOXD3: NX_P31249

Explore proteomics data for HOXD3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P31249

  • HOXD3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HOXD3 Protein Expression
    REFSEQ proteins: NP_008829.3  
    ENSEMBL proteins: 
     ENSP00000392615   ENSP00000424734   ENSP00000386498   ENSP00000249440  

    Human Recombinant Protein Products for HOXD3: 
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HOXD3 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IC12836255

    HOXD3 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for HOXD3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HOXL: Homeoboxes / ANTP class : HOXL subclass

    5/6 InterPro protein domains (see all 6):
     IPR001827 Homeobox_Antennapedia_CS
     IPR020479 Homeobox_metazoa
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P31249

    ProtoNet protein and cluster: P31249

    2 Blocks protein domains:
    IPB000047 Lambda and other repressor helix-turn-helix signature
    IPB001827 Homeobox protein


    UniProtKB/Swiss-Prot: HXD3_HUMAN, P31249
    Similarity: Belongs to the Antp homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    HOXD3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HXD3_HUMAN, P31249
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
    cells with specific positional identities on the anterior-posterior axis

         Genatlas biochemistry entry for HOXD3:
    homeo box D3(4A),homologous to mouse Hox-4.1,Drosophila Zen

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI--
    GO:0043565sequence-specific DNA binding IEA--
         
    HOXD3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HOXD3:
     Decreased Wnt reporter activit 

         11 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Hoxd3):
     cardiovascular system  cellular  craniofacial  embryogenesis  endocrine/exocrine gland 
     hematopoietic system  immune system  mortality/aging  nervous system  respiratory system 
     skeleton 

    HOXD3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for HOXD3: Hoxd3tm2Mrc Hoxd3tm1Mrc

       inGenious Targeting Laboratory - Custom generated mouse model solutions for HOXD3 
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HOXD3 

    miRNA
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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXD3 (see all 9):
    hsa-miR-21* hsa-miR-3671 hsa-miR-1226 hsa-miR-1283 hsa-miR-548o hsa-miR-500a hsa-miR-606 hsa-miR-466
    SwitchGear 3'UTR luciferase reporter plasmidHOXD3 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXD3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HOXD3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/9 Interacting proteins for HOXD3 (P312491, 3 ENSP000002494404) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALX4Q9H1613, ENSP000003327444I2D: score=1 STRING: ENSP00000332744
    HMGB1P094293, ENSP000003430404I2D: score=1 STRING: ENSP00000343040
    DDB1Q165313, ENSP000003017644I2D: score=1 STRING: ENSP00000301764
    CERS2Q96G233I2D: score=1 
    CSDE1O755343I2D: score=1 
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IMP12836255
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007160cell-matrix adhesion IDA7742539
    GO:0007219Notch signaling pathway IMP12836255
    GO:0009952anterior/posterior pattern specification ISS--

    HOXD3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HOXD3 (HXD3)

    Search CenterWatch for drugs/clinical trials and news about HOXD3 / HXD3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HOXD3 gene: 
    NM_006898.4  

    Unigene Cluster for HOXD3:

    Homeobox D3
    Hs.93574  [show with all ESTs]
    Unigene Representative Sequence: BC005124
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000459979(uc002ukr.3) ENST00000432796 ENST00000468418 ENST00000410016
    ENST00000249440(uc002ukt.1)
    miRNA
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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXD3 (see all 9):
    hsa-miR-21* hsa-miR-3671 hsa-miR-1226 hsa-miR-1283 hsa-miR-548o hsa-miR-500a hsa-miR-606 hsa-miR-466
    SwitchGear 3'UTR luciferase reporter plasmidHOXD3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HOXD3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXD3
    Clone
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    GenScript: all cDNA clones in your preferred vector: HOXD3 (NM_006898)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXD3
    Sirion Biotech Customized lentivirus for stable overexpression of HOXD3 
                         Customized lentivirus expression plasmids for stable overexpression of HOXD3 
    Primer
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    OriGene qPCR primer pairs and template standards for HOXD3
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXD3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXD3

    Additional mRNA sequence: 

    BC005124.2 BC008789.2 

    2 DOTS entries:

    DT.75105776  DT.99968895 

    24/28 AceView cDNA sequences (see all 28):

    BF739816 NM_006898 AI373293 AW300138 BE463473 AI911593 BC008789 AI769665 
    AI955470 BC047605 BF114998 BC005124 AW137579 AI373320 BE348261 AI478225 
    AW138896 AW271503 AI223210 AI927335 BM543946 AI521702 AA434183 BE797724 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HOXD3 expression in normal human tissues (normalized intensities)      HOXD3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTAGAGTCA
    HOXD3 Expression
    About this image


    HOXD3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Angioblasts Proepicardium
             Peripheral blood-derived endothelial progenitor cells
     
     Neural Crest (Gastrulation Derivatives)
             Cardiac Neural Crest Cells Branchial Arch 3,4,6
     
     Tendon & Ligament
             Cervical Sclerotome Cells Cervical Mesenchymal Sclerotome
     
     Bone (Muscoskeletal System)
             Cervical Sclerotome Cells Cervical Mesenchymal Sclerotome

    See HOXD3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HOXD3

    SOURCE GeneReport for Unigene cluster: Hs.93574
        SABiosciences Expression via Pathway-Focused PCR Array including HOXD3: 
              Homeobox (HOX) Genes in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXD3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HOXD3 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hoxd31 , 5 homeobox D31, 5 90.97(n)1
    95.83(a)1
      2 (44.13 cM)5
    154341  NM_010468.21  NP_034598.21 
     747119295 
    chicken
    (Gallus gallus)
    Aves HOXD31 homeobox D3 77.91(n)
    79.61(a)
      431212  XM_428765.3  XP_428765.2 
    lizard
    (Anolis carolinensis)
    Reptilia HOXD36
    --
    Uncharacterized protein
    72(a)
    33(a)
    1 ↔ 1
    possible ortholog
    GL343356.1(402731-409310)
    2(71908820-71911179)
    zebrafish
    (Danio rerio)
    Actinopterygii hoxd3a1 homeo box D3a 66.58(n)
    70.38(a)
      30349  NM_131125.1  NP_571200.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta zen26
    zen6
    zerknullt
    23(a)
    18(a)
    many ↔ many
    many ↔ many
    3R(2568854-2569862)
    3R(2578586-2579916)
    worm
    (Caenorhabditis elegans)
    Secernentea mab-56
    egl-56
    Homeobox protein egl-5
    26(a)
    19(a)
    many ↔ many
    many ↔ many
    III(7776907-7783454)
    III(7814382-7816451)


    ENSEMBL Gene Tree for HOXD3 (if available)
    TreeFam Gene Tree for HOXD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HOXD3 gene
    GSX12  HOXA72  HOXA12  HOXB32  HOXD12  HOXA22  HOXB52  HOXC62  
    HOXC52  GSX22  HOXB42  HOXA52  HOXA42  HOXA62  HOXC82  HOXA32  
    HOXD82  HOXB62  HOXB12  HOXB82  HOXB22  HOXD42  PDX12  HOXB72  
    HOXC42  
    4 SIMAP similar genes for HOXD3 using alignment to 3 protein entries:     HXD3_HUMAN (see all proteins):
    HOXA3    HOXB3    HOXD8    HOXB6

    HOXD3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/218 SNPs in HOXD3 are shown (see all 218)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs567612171,2
    C--168909284(+) TTTTT-/TTTTTTT/TTTT
    TTTT
    /TTTTTTTTTT
    AAGTT
    1 -- int11NA 2
    rs9668011,2
    C,F,A,H--176432703(+) CAGTCA/GGAACT 1 -- ut3114Minor allele frequency- G:0.42MN NA WA CSA EA 565
    rs1453307141,2
    --177026810(+) GGTTGC/GGACAG 1 -- us2k10--------
    rs1852212371,2
    --177026837(+) AACCGA/CCTTCC 1 -- us2k10--------
    rs1905463711,2
    --177026933(+) ATTTTC/TCTTTG 1 -- us2k10--------
    rs1141187991,2
    --177027022(+) ATGGAA/GCATTC 1 -- us2k10--------
    rs1823744731,2
    --177027049(+) GAAAAC/TTTCAA 1 -- us2k10--------
    rs1476726231,2
    C--177027065(+) CCTACC/TAAGGC 1 -- us2k10--------
    rs347204561,2
    C,F--177027292(+) GACCCG/ACGTGG 1 -- us2k16Minor allele frequency- A:0.19NA CSA WA EA 366
    rs126200321,2
    C,H--177027833(+) GCCCTA/TCCGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HOXD3 (177001340 - 177037830 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HOXD3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv875438CNV Loss21882294
    dgv676n67CNV Gain20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 142980    OMIM disorders: --

    13 diseases for HOXD3:    About MalaCards
    duane retraction syndrome    vacterl association    clubfoot    esophageal atresia
    prostate cancer, progression of    prostate cancer    esophagitis    cerebritis
    prostatitis    ovarian cancer    thyroiditis    melanoma
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for HOXD3:
    VACTERL association

    HOXD3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): HOXD3
    Human Genome Epidemiology (HuGE) Navigator: HOXD3 (3 documents)

    Export disorders for HOXD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HOXD3 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with HOXD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genome-wide association study identifies susceptibi lity loci for ovarian cancer at 2q31 and 8q24. (PubMed id 20852632)1, 4 Goode E.L....Pharoah P.D. (2010)
    2. Altered transmission of HOX and apoptotic SNPs identi fy a potential common pathway for clubfoot. (PubMed id 19938081)1, 4 Ester A.R....Hecht J.T. (2009)
    3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (1992)
    6. Cloning and sequencing of the human homeobox gene HOX4A. (PubMed id 1358204)1, 2 Taniguchi Y.... Moriuchi T. (1992)
    7. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (1990)
    8. Organization of human class I homeobox genes. (PubMed id 2576652)1, 2 Boncinelli E.... Simeone A. (1989)
    9. Overexpression of the HOX4A (HOXD3) homeobox gene in human erythroleukemia HEL cells results in altered adhesive properties. (PubMed id 7742539)1, 9 Taniguchi Y....Moriuchi T. (1995)
    10. Expression of HOXD3 correlates with shorter survival i n patients with invasive breast cancer. (PubMed id 22935821)1 Shaoqiang C....Qingyuan Z. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3232 HGNC: 5137 AceView: HOXD3 Ensembl:ENSG00000128652 euGenes: HUgn3232
    ECgene: HOXD3 H-InvDB: HOXD3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HOXD3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HOXD3 gene:
    Search GeneIP for patents involving HOXD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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