Aliases for HOXD12 Gene
External Ids for HOXD12 Gene
Previous HGNC Symbols for HOXD12 Gene
Previous GeneCards Identifiers for HOXD12 Gene
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The exact role of this gene has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOXD12 Gene
HOXD12 (Homeobox D12) is a Protein Coding gene. Diseases associated with HOXD12 include Brachydactyly-Syndactyly Syndrome and Syndactyly, Type V. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is HOXC12.
UniProtKB/Swiss-Prot for HOXD12 Gene
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.