Aliases for HOXD11 Gene
Aliases for HOXD11 Gene
External Ids for HOXD11 Gene
- HGNC: 5134
- Entrez Gene: 3237
- Ensembl: ENSG00000128713
- OMIM: 142986
- UniProtKB: P31277
Previous HGNC Symbols for HOXD11 Gene
- HOX4
- HOX4F
Previous GeneCards Identifiers for HOXD11 Gene
- GC02P175024
- GC02P175633
- GC02P176936
- GC02P177174
- GC02P176797
- GC02P176680
- GC02P168849
Summaries for HOXD11 Gene
-
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in forelimb morphogenesis. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOXD11 Gene
HOXD11 (Homeobox D11) is a Protein Coding gene. Diseases associated with HOXD11 include Syndactyly, Type V and Brachydactyly-Syndactyly Syndrome. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is HOXD10.
UniProtKB/Swiss-Prot for HOXD11 Gene
-
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXD11 Gene
Genomics for HOXD11 Gene
Regulatory Elements for HOXD11 Gene
Enhancers for HOXD11 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around HOXD11 on UCSC Golden Path with GeneCards custom track
Promoters for HOXD11 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around HOXD11 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HOXD11 gene promoter:
Regulatory Element Products
Genomic Location for HOXD11 Gene
- Chromosome:
- 2
- Start:
- 176,104,216 bp from pter
- End:
- 176,109,754 bp from pter
- Size:
- 5,539 bases
- Orientation:
- Plus strand
Genomic View for HOXD11 Gene
Genes around HOXD11 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q31.1 by Ensembl
- 2q31.1 by Entrez Gene
- 2q31.1 by HGNC
HOXD11 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HOXD11 Gene
Proteins for HOXD11 Gene
-
Protein details for HOXD11 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P31277-HXD11_HUMAN
- Recommended name:
- Homeobox protein Hox-D11
- Protein Accession:
- P31277
- A6NIS4
- Q9NS02
Protein attributes for HOXD11 Gene
- Size:
- 338 amino acids
- Molecular mass:
- 35197 Da
- Quaternary structure:
- No Data Available
Protein Expression for HOXD11 Gene
Post-translational modifications for HOXD11 Gene
Other Protein References for HOXD11 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HOXD11
- Abcam antibodies for HOXD11
- Invitrogen Antibodies for HOXD11
- antibodies-online Antibodies for HOXD11: See all 52
- GeneTex HOXD11 antibody for HOXD11
-
Santa Cruz Biotechnology (SCBT) Antibodies for HOXD11
Protein Products
-
OriGene Purified Proteins for HOXD11
- Search Origene for MassSpec and Protein Over-expression Lysates for HOXD11
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- antibodies-online Proteins for HOXD11: See all 7
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HOXD11
- Abcam proteins for HOXD11
Assay Products
No data available for DME Specific Peptides for HOXD11 Gene
Domains & Families for HOXD11 Gene
Gene Families for HOXD11 Gene
Protein Domains for HOXD11 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HOXD11 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P31277UniProtKB/Swiss-Prot:
HXD11_HUMAN :- Contains 1 homeobox DNA-binding domain.
- Belongs to the Abd-B homeobox family.
- Domain:
-
- Contains 1 homeobox DNA-binding domain.
- Family:
-
- Belongs to the Abd-B homeobox family.
Function for HOXD11 Gene
Molecular function for HOXD11 Gene
- GENATLAS Biochemistry:
- homeo box D11(4F),homologous to mouse Hox-4.6
- UniProtKB/Swiss-Prot Function:
- Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
Phenotypes for HOXD11 Gene
- MGI mutant phenotypes for HOXD11:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for HOXD11:
Animal Models for HOXD11 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXD11 gene
-
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- Search ViGene Biosciences for HOXD11
CRISPR Products
-
OriGene CRISPR knockouts for HOXD11
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXD11
- GenScript: Design CRISPR guide RNA sequences for HOXD11
miRNA for HOXD11 Gene
- miRTarBase miRNAs that target HOXD11
-
- hsa-mir-744-5p (MIRT037516)
- hsa-let-7b-5p (MIRT051956)
- hsa-mir-10b-5p (MIRT439125)
- hsa-mir-3674 (MIRT557015)
- hsa-mir-27b-3p (MIRT557016)
- hsa-mir-27a-3p (MIRT557017)
- hsa-mir-513a-5p (MIRT557018)
- hsa-mir-5701 (MIRT557019)
- hsa-mir-4326 (MIRT557020)
- hsa-mir-205-3p (MIRT557021)
- hsa-mir-454-3p (MIRT557022)
- hsa-mir-4295 (MIRT557023)
- hsa-mir-3666 (MIRT557024)
- hsa-mir-301b-3p (MIRT557025)
- hsa-mir-301a-3p (MIRT557026)
- hsa-mir-130b-3p (MIRT557027)
- hsa-mir-130a-3p (MIRT557028)
- hsa-mir-32-3p (MIRT557029)
- hsa-mir-93-5p (MIRT557030)
- hsa-mir-106a-5p (MIRT557031)
- hsa-mir-106b-5p (MIRT557032)
- hsa-mir-17-5p (MIRT557033)
- hsa-mir-20b-5p (MIRT557034)
- hsa-mir-519d-3p (MIRT557035)
- hsa-mir-526b-3p (MIRT557036)
- hsa-mir-20a-5p (MIRT557037)
- hsa-mir-129-5p (MIRT616267)
- hsa-mir-450a-5p (MIRT616268)
- hsa-mir-6887-5p (MIRT616269)
- hsa-mir-6795-5p (MIRT616270)
- hsa-mir-6870-5p (MIRT616271)
- hsa-mir-7111-5p (MIRT616272)
- hsa-mir-5698 (MIRT616273)
- hsa-mir-4723-5p (MIRT616274)
- hsa-mir-4706 (MIRT616275)
- hsa-mir-4749-5p (MIRT616276)
- hsa-mir-329-5p (MIRT616277)
miRNA Products
- Search ViGene Biosciences for HOXD11
Inhibitory RNA Products
- Origene RNAi, shRNA, mouse_rna, and siRNA products in human, mouse, rat for HOXD11
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-
ViGene Biosciences ready-to-package AAV shRNAs for HOXD11 gene
Clone Products
- OriGene clones in human for HOXD11
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Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for HOXD11 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXD11 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXD11 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXD11 Gene
Localization for HOXD11 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HOXD11 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
No data available for Gene Ontology (GO) - Cellular Components for HOXD11 Gene
Pathways & Interactions for HOXD11 Gene
More details on SuperPathways for HOXD11
No Data Available
Interacting Proteins for HOXD11 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001658 | branching involved in ureteric bud morphogenesis | ISS | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
No data available for Pathways by source for HOXD11 Gene
Transcripts for HOXD11 Gene
mRNA/cDNA for HOXD11 Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (56) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HOXD11
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXD11
- GenScript: Design CRISPR guide RNA sequences for HOXD11
miRNA Products
- Search ViGene Biosciences for HOXD11
Inhibitory RNA Products
- Origene RNAi, shRNA, mouse_rna, and siRNA products in human, mouse, rat for HOXD11
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-
ViGene Biosciences ready-to-package AAV shRNAs for HOXD11 gene
Clone Products
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Flow Cytometry Products
Expression for HOXD11 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Prechondrocytic Mesenchymal Cells Dorsal Neural Arch
- Sclerotome Cells Sacral Mesenchymal Sclerotome
- Prechondrocytic Mesenchymal Cells Lateral Neural Arch
- Prechondrocytic Mesenchymal Cells Spinous Process Of Vertebrae
- Prechondrocytic Mesenchymal Cells Central Neural Arch
-
Cartilage (Muscoskeletal System)
- Prechondrocytic Mesenchymal Cells Dorsal Neural Arch
- Sclerotome Cells Sacral Mesenchymal Sclerotome
- Prechondrocytic Mesenchymal Cells Lateral Neural Arch
- Prechondrocytic Mesenchymal Cells Spinous Process Of Vertebrae
- Prechondrocytic Mesenchymal Cells Central Neural Arch
-
Kidney (Urinary System)
- Metanephric Mesenchyme Cells Metanephric Mesenchyme
- Metanephros
- mK4
- mK3
- Renal progenitor cells(Takasato M et. al. 2014)
-
Limb (Muscoskeletal System)
- Zone Of Polarizing Activity Cells Limb Bud
- Prechondrocytic Mesenchymal Cells Zeugopod
- Limb Bud Mesenchyme Cells Limb Bud
- Limb Bud
-
Mesoderm (Gastrulation Derivatives)
- Zone Of Polarizing Activity Cells Limb Bud
- Limb Bud Mesenchyme Cells Limb Bud
- Mesenchymal Stem Cells (Uncategorized)
- Placenta (Extraembryonic Tissues)
-
Somite (Muscoskeletal System)
- Sclerotome Cells Sacral Mesenchymal Sclerotome
-
Tendon amp Ligament
- Sclerotome Cells Sacral Mesenchymal Sclerotome
- Eye (Sensory Organs)
- NULL (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for HOXD11 Gene
This gene is overexpressed in Uterus (x13.3), Vagina (x9.7), Colon - Sigmoid (x9.5), Prostate (x5.8), Cervix - Ectocervix (x5.2), and Kidney - Cortex (x4.0).
This gene is overexpressed in Adipocyte (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HOXD11 Gene
SOURCE GeneReport for Unigene cluster for HOXD11 Gene Hs.421136
Primer Products
-
OriGene qPCR primer pairs for HOXD11
No data available for mRNA Expression by UniProt/SwissProt for HOXD11 Gene
Orthologs for HOXD11 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | HOXD11 35 |
|
||
| HOXD 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Hoxd11 35 |
|
||
| Hoxd11 16 |
|
||||
| Hoxd11 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | HOXD11 35 |
|
||
| HOXD11 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | HOXD11 36 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | HOXD11 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 36 |
|
ManyToMany | |
| chicken (Gallus gallus) |
Aves | HOXD11 35 |
|
||
| HOXD11 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | HOXD11 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hoxd11 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hoxd11a 35 |
|
||
| hoxd11a 36 |
|
OneToOne | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 36 |
|
OneToMany |
- Species with no ortholog for HOXD11:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HOXD11 Gene
Paralogs for HOXD11 Gene
(13) SIMAP similar genes for HOXD11 Gene using alignment to 2 proteins:
Variants for HOXD11 Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_031647 | - | ||||
| rs847146 | -- | 176,108,354(-) | ACAGC(G/T)ATTAA | intron-variant | |
| rs847147 | -- | 176,105,931(-) | TCAGC(C/T)CCTCC | upstream-variant-2KB | |
| rs847148 | -- | 176,105,728(-) | CCGAG(A/T)GAGCA | upstream-variant-2KB | |
| rs863678 | -- | 176,109,376(-) | TGTAA(A/C)GGGAC | utr-variant-3-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv520227 | CNV | Loss | 19592680 |
| dgv676n67 | CNV | Gain | 20364138 |
| nsv875437 | CNV | Loss | 21882294 |
| nsv875438 | CNV | Loss | 21882294 |
| nsv527187 | CNV | Loss | 19592680 |
| nsv517968 | CNV | Loss | 19592680 |
| dgv4368n71 | CNV | Loss | 21882294 |
| nsv524250 | CNV | Loss | 19592680 |
| nsv875441 | CNV | Loss | 21882294 |
| nsv875442 | CNV | Loss | 21882294 |
| dgv4369n71 | CNV | Loss | 21882294 |
| nsv875446 | CNV | Loss | 21882294 |
| nsv875447 | CNV | Loss | 21882294 |
Gene Damage Index Score:
1.42;
27.96% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HOXD11 Gene
Disorders for HOXD11 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| syndactyly, type v |
|
|
| brachydactyly-syndactyly syndrome |
|
|
Search HOXD11 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for HOXD11
No data available for UniProtKB/Swiss-Prot and Genatlas for HOXD11 Gene
Publications for HOXD11 Gene
- Study of HOXD genes in autism particularly regarding the ratio of second to fourth digit length. (PMID: 19540081) Sugie Y. … Osawa J. (Brain Dev. 2010) 3 48 67
- The HOXD11 gene is fused to the NUP98 gene in acute myeloid leukemia with t(2;11)(q31;p15). (PMID: 11782354) Taketani T. … Hayashi Y. (Cancer Res. 2002) 3 23
- Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott M.P. (Cell 1992) 2 3
- Nomenclature for human homeobox genes. (PMID: 1973146) McAlpine P.J. … Shows T.B. (Genomics 1990) 2 3
- POU2F1 activity regulates HOXD10 and HOXD11 promoting a proliferative and invasive phenotype in head and neck cancer. (PMID: 25301728) Sharpe D.J. … James J.A. (Oncotarget 2014) 3
Products for HOXD11 Gene
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- antibodies-online Antibodies for HOXD11: See all 52
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- antibodies-online Proteins for HOXD11: See all 7
- Search antibodies-online for peptides
- GeneTex HOXD11 antibody for HOXD11
- Search GeneTex for Proteins for HOXD11
- ViGene Biosciences adenoviral particle packaged cDNA for HOXD11 gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for HOXD11
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Sources for HOXD11 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
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