Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneAnalytics
- GeneLoc
- GenesLikeMe
- VarElect
- PathCards
Terms of Use
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
GeneCards Plus
- Premium Tools
  
  Learn more

Set Analyses:

VarElect

Advanced Search

HOXD11 Gene

protein-coding GIFtS: 51
GCID: GC02P176936

Homeobox D11

(Previous name: homeo box D11)
(Previous symbols: HOX4, HOX4F)

See HOXD11-related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

TryGeneCards Plus

Aliases
Homeobox D11¹ ²		Homeobox Protein Hox-4F² ³
HOX4F¹ ² ³ ⁵		Homeo Box 4F²
HOX4¹ ²		Homeobox Protein Hox-D11²
Homeo Box D11¹ ²		Hox-4.6, Mouse, Homolog Of²

External Ids:	HGNC: 5134¹	Entrez Gene: 3237²	Ensembl: ENSG00000128713⁷	OMIM: 142986⁵	UniProtKB: P31277³

Export aliases for HOXD11 gene to outside databases

Previous GC identifers: GC02P175024 GC02P175633 GC02P177174 GC02P176797 GC02P176680 GC02P168849

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for HOXD11 Gene:

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of

transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals

possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes,

consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a

cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have

been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in

forelimb morphogenesis. (provided by RefSeq, Jul 2008)

GeneCards Summary for HOXD11 Gene:

HOXD11 (homeobox D11) is a protein-coding gene. Diseases associated with HOXD11 include brachydactyly-syndactyly syndrome, and acute myeloid leukemia. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ENSG00000257184.

UniProtKB/Swiss-Prot: HXD11_HUMAN, P31277

Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides

cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXD11 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus

RefSeq DNA sequence at NCBI GenBank:

NC_000002.11 NT_005403.18 NC_018913.2

Regulatory elements:

Regulatory transcription factor binding sites in the HOXD11 gene promoter:
E2F-4 E2F-3a PPAR-gamma1 E2F-2 Nkx2-5 PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HOXD11 promoter sequence

Search Chromatin IP Primers for HOXD11

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HOXD11

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1 Ensembl cytogenetic band: 2q31.1 HGNC cytogenetic band: 2q31.1

HOXD11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXD11 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P176936: view genomic region (about GC identifiers)

Start:	176,968,944 bp from pter	End:	176,974,722 bp from pter
Size:	5,779 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: HXD11_HUMAN, P31277 (See protein sequence)

Recommended Name: Homeobox protein Hox-D11

Size: 338 amino acids; 35197 Da

Secondary accessions: A6NIS4 Q9NS02

Explore the universe of human proteins at neXtProt for HOXD11: NX_P31277

Explore proteomics data for HOXD11 at MOPED

See HOXD11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_067015.2

ENSEMBL proteins:

ENSP00000249504

HOXD11 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for HOXD11 OriGene Custom MassSpec OriGene Custom Protein Services for HOXD11
	GenScript Custom Purified and Recombinant Proteins Services for HOXD11
	Novus Biologicals HOXD11 Protein Novus Biologicals HOXD11 Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for HOXD11
	Search eBioscience for Proteins for HOXD11
	antibodies-online proteins for HOXD11 (7 products)
	antibodies-online peptides for HOXD11

HOXD11 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies for HOXD11 OriGene Custom Antibody Services for HOXD11
	Novus Biologicals HOXD11 Antibodies
	Abcam antibodies for HOXD11
	Cloud-Clone Corp. Antibodies for HOXD11
	Search ThermoFisher Antibodies for HOXD11
	antibodies-online antibodies for HOXD11 (36 products)

HOXD11 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for HOXD11
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for HOXD11
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for HOXD11 Cloud-Clone Corp. CLIAs for HOXD11
	Search eBioscience for ELISAs for HOXD11
	antibodies-online kits for HOXD11 (6 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus

HGNC Gene Families:

HOXL: Homeoboxes / ANTP class : HOXL subclass

5 InterPro protein domains:

IPR021918 DUF3528

IPR020479 Homeobox_metazoa

IPR017970 Homeobox_CS

IPR001356 Homeobox_dom

IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry P31277

ProtoNet protein and cluster: P31277

UniProtKB/Swiss-Prot: HXD11_HUMAN, P31277

Similarity: Belongs to the Abd-B homeobox family

Similarity: Contains 1 homeobox DNA-binding domain

Find genes that share domains with HOXD11 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

UniProtKB/Swiss-Prot Summary: HXD11_HUMAN, P31277

Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides

cells with specific positional identities on the anterior-posterior axis

Genatlas biochemistry entry for HOXD11:

homeo box D11(4F),homologous to mouse Hox-4.6

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0043565	sequence-specific DNA binding	IEA	--

Find genes that share ontologies with HOXD11 About GenesLikeMe

Phenotypes:
9 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Hoxd11):

cellular	embryogenesis	limbs/digits/tail	mortality/aging	nervous system
no phenotypic analysis	renal/urinary system	reproductive system	skeleton

Find genes that share phenotypes with HOXD11 About GenesLikeMe

Animal Models:
MGI mouse knock-outs for HOXD11: Evx2/Hoxd11/Hoxd12/Hoxd13^{Evx2/Hoxd11/Hoxd12/tm1Ddu} Hoxd11^tm2.1Ddu Hoxd11^tm1Mrc Hoxd11^tm2Ddu Hoxd11^tm1Ipc

genOway: Develop your customized and physiologically relevant rodent model for HOXD11

miRNA Products:		miRTarBase miRNAs that target HOXD11: hsa-let-7b-5p (MIRT051956), hsa-mir-744-5p (MIRT037516)

		Block miRNA regulation of human, mouse, rat HOXD11 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate HOXD11
		SwitchGear 3'UTR luciferase reporter plasmid: HOXD11 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for HOXD11
		Predesigned siRNA for gene silencing in human, mouse, rat HOXD11

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for HOXD11

Clone Products:		OriGene clones in human, mouse for HOXD11 (see all 5) OriGene ORF clones in mouse, rat for HOXD11 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HOXD11 (NM_021192)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXD11
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXD11

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HOXD11
		Browse ESI BIO Cell Lines and PureStem Progenitors for HOXD11

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXD11

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot

HXD11_HUMAN, P31277: Nucleus

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	5

About this image

Gene Ontology (GO): 1 cellular component term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

Find genes that share ontologies with HOXD11 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

Pathway & Disease-focused RT² Profiler PCR Array including HOXD11:

Homeobox (HOX) Genes in human mouse rat

Interactions:

Search GeneGlobe Interaction Network for HOXD11

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

Selected Interacting proteins for HOXD11 (P31277³ ENSP00000249504⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MEIS1	O00470³, ENSP00000272369⁴	I2D: score=1 STRING: ENSP00000272369
HMGB1	P09429³, ENSP00000343040⁴	I2D: score=1 STRING: ENSP00000343040
MEIS2	ENSP00000326296⁴	STRING: ENSP00000326296
GMNN	ENSP00000230056⁴	STRING: ENSP00000230056
LINS	ENSP00000318423⁴	STRING: ENSP00000318423

About this table

Gene Ontology (GO): Selected biological process terms (see all 19): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001501	skeletal system development	--	--
GO:0001656	metanephros development	IEA	--
GO:0001658	branching involved in ureteric bud morphogenesis	ISS	--
GO:0001759	organ induction	IEA	--
GO:0006351	transcription, DNA-templated	IEA	--

Find genes that share ontologies with HOXD11 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for HOXD11 (HXD11)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for HOXD11 gene:

NM_021192.2

Unigene Cluster for HOXD11:

Homeobox D11

Hs.421136 [show with all ESTs]

Unigene Representative Sequence: NM_021192

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000498438(uc010fqx.3) ENST00000249504(uc002uki.3)

miRNA Products:		Block miRNA regulation of human, mouse, rat HOXD11 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate HOXD11
		SwitchGear 3'UTR luciferase reporter plasmid: HOXD11 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for HOXD11
		Predesigned siRNA for gene silencing in human, mouse, rat HOXD11

Clone Products:		OriGene clones in human, mouse for HOXD11 (see all 5) OriGene ORF clones in mouse, rat for HOXD11 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HOXD11 (NM_021192)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXD11
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXD11

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for HOXD11
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat HOXD11
		QuantiTect SYBR Green Assays in human, mouse, rat HOXD11
		QuantiFast Probe-based Assays in human, mouse, rat HOXD11

Additional mRNA sequence:

AK309681.1 BC109394.1

4 DOTS entries:

DT.70105486 DT.97771570 DT.408703 DT.100707782

Selected AceView cDNA sequences (see all 56):

BC074760 NM_002148 AI139039 AI095929 AW205221 AA653427 NM_021192 BF510955

BC069619 AW206798 BX114645 X59373 AA442532 AA479366 BF680250 AI277208

BF526767 AW194680 CA431276 AW195017 AW630600 AI423516 CD614162 BX117343

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

HOXD11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CAACGCGAGC

About this image

HOXD11 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 11) fully expand


Kidney (Urinary System) fully expand to see all 6 entries
Metanephric Mesenchyme Cells Metanephric Mesenchyme
Metanephros
mK3
Intermediate mesoderm derivatives

Limb (Muscoskeletal System) fully expand to see all 4 entries
Limb Bud Mesenchyme Cells Limb Bud
Limb Bud

Bone (Muscoskeletal System) fully expand to see all 3 entries
Sacral Sclerotome Cells Sacral Mesenchymal Sclerotome
Zeugopod Long Bone

Mesoderm (Gastrulation Derivatives) fully expand to see all 2 entries
Limb Bud Mesenchyme Cells Limb Bud

Cartilage (Muscoskeletal System) fully expand to see all 2 entries
Sacral Sclerotome Cells Sacral Mesenchymal Sclerotome

HOXD11 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

HOXD11 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.421136

Pathway & Disease-focused RT² Profiler PCR Array including HOXD11:

Homeobox (HOX) Genes in human mouse rat

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for HOXD11
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat HOXD11
		QuantiTect SYBR Green Assays in human, mouse, rat HOXD11
		QuantiFast Probe-based Assays in human, mouse, rat HOXD11

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXD11

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of chordates.

Orthologs for HOXD11 gene from Selected species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Hoxd11^{1 , 5}	homeobox D11^{1, 5}	87.2(n)¹ 89.88(a)¹		2 (44.13 cM)⁵ 15431¹ NM_008273.2¹ NP_032299.1¹ 74679392⁵
chicken (Gallus gallus)	Aves	HOXD11¹	homeobox D11	72.5(n) 71.79(a)		395328 NM_204620.1 NP_989951.1
lizard (Anolis carolinensis)	Reptilia	HOXD11⁶	homeobox D11	63(a)	1 ↔ 1	GL343356.1(556257-559822)
tropical clawed frog (Xenopus tropicalis)	Amphibia	hoxd11¹	homeobox D11	65.33(n) 64.96(a)		100497945 XM_002935676.2 XP_002935722.1
zebrafish (Danio rerio)	Actinopterygii	hoxd11a¹	homeo box D11a	58.91(n) 56(a)		30405 NM_131167.1 NP_571242.1

ENSEMBL Gene Tree for HOXD11 (if available)
TreeFam Gene Tree for HOXD11 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

TryGeneCards Plus

Paralogs for HOXD11 gene

ENSG00000257184² HOXD10² HOXC13² HOXC10² HOXD12² HOXA9² HOXA13² HOXC9²

HOXB13² HOXC12² HOXC11² HOXD13² HOXA11² HOXB9² HOXD9² HOXA10²

13 SIMAP similar genes for HOXD11 using alignment to 2 protein entries: HXD11_HUMAN (see all proteins):

CDX1 HOX B6 HOXC13 HOXB1 HOXA4 HOXB8

HOXA-9 HOXA11 HOXB3 HOXD13 GBX1 HOXC11

HOXA10

Find genes that share paralogs with HOXD11 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs188896135^1,2		--	176970117(+)	`AAGGGG/TCGGAG`	1	--	us2k¹		0	--	--	--	--
rs116425345^1,2	C,F	--	176970121(+)	`GGCGGA/GGGAAG`	1	--	us2k¹		1		WA	118
rs201828765^1,2	C	--	176970168(+)	`AGGAA-/GGGGGG`	1	--	us2k¹		0	--	--	--	--
rs117257637^1,2	C,F	--	176970185(+)	`CAGCCA/GGAAAA`	1	--	us2k¹		1		EA	120
rs72923436^1,2	C,F	--	176970247(+)	`CAGAGC/AGCACA`	1	--	us2k¹		2		WA NA	238
rs3813811^1,2	C,F,H	--	176970340(-)	`CTGGGG/ACCTGG`	1	--	us2k¹		4		NS EA	418
rs73033720^1,2	C,F	--	176970401(+)	`CCCTCG/TGTTCT`	1	--	us2k¹		2		WA	120
rs847148^1,2	C,F,H	--	176970456(-)	`CCGAGT/AGAGCA`	1	--	us2k¹		16		NS EA NA WA CSA	791
rs847147^1,2	C,F,A,H	--	176970659(-)	`TCAGCC/TCCTCC`	1	--	us2k¹ tfbs³ trp³		23		MN NS EA NA WA CSA	2417
rs80340731^1,2	C,F	--	176970735(+)	`TTGGCG/CGGGCT`	1	--	us2k¹		2		CSA WA	119

HapMap Linkage Disequilibrium report for HOXD11 (176968944 - 176974722 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for HOXD11 (see all 13): About this table

Variant ID	Type	Subtype	PubMed ID
nsv520227	CNV	Loss	19592680
nsv875441	CNV	Loss	21882294
nsv875447	CNV	Loss	21882294
nsv875442	CNV	Loss	21882294
dgv4368n71	CNV	Loss	21882294
nsv524250	CNV	Loss	19592680
nsv875438	CNV	Loss	21882294
nsv875446	CNV	Loss	21882294
nsv875437	CNV	Loss	21882294
dgv4369n71	CNV	Loss	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing HOXD11

DNA2.0 Custom Variant and Variant Library Synthesis for HOXD11

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus

OMIM gene information: 142986 OMIM disorders: --

2 diseases for HOXD11:
About MalaCards

brachydactyly-syndactyly syndrome acute myeloid leukemia

2 inferred disease relationships from the University of Copenhagen DISEASES database for HOXD11:

Polydactyly Renal agenesis

Find genes that share disorders with HOXD11 About GenesLikeMe

Genetic Association Database (GAD): HOXD11
Human Genome Epidemiology (HuGE) Navigator: HOXD11 (5 documents)

Export disorders for HOXD11 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for HOXD11 gene, integrated from 10 sources (see all 33):
(articles sorted by number of sources associating them with HOXD11)

Utopia: connect your pdf to the dynamic
world of online information

Study of HOXD genes in autism particularly regarding the ratio of second to fourth digit length. (PubMed id 19540081)^{1, 4} Sugie Y....Osawa J. (amp 2010)
Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot. (PubMed id 19938081)^{1, 4} Ester A.R....Hecht J.T. (Am. J. Med. Genet. A 2009)
Absence of mutations in the HOXA11 and HOXD11 genes in children with congenital renal malformations. (PubMed id 19255789)^{1, 4} Bouba I....Georgiou I. (Pediatr. Nephrol. 2009)
High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)^{1, 4} Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
Mutations in HOXD13 underlie syndactyly type V and a novel brachydactyly-syndactyly syndrome. (PubMed id 17236141)^{1, 2} Zhao X.... Zhang X. (Am. J. Hum. Genet. 2007)
Vertebrate homeobox gene nomenclature. (PubMed id 1358459)^{1, 3} Scott M.P. (Cell 1992)
Nomenclature for human homeobox genes. (PubMed id 1973146)^{1, 3} McAlpine P.J. and Shows T.B. (Genomics 1990)
The human HOX gene family. (PubMed id 2574852)^{1, 2} Acampora D.... Boncinelli E. (Nucleic Acids Res. 1989)
The HOXD11 gene is fused to the NUP98 gene in acute myeloid leukemia with t(2;11)(q31;p15). (PubMed id 11782354)^{1, 9} Taketani T....Hayashi Y. (Cancer Res. 2002)
A region of the human HOXD cluster that confers polycomb-group responsiveness. (PubMed id 20085705)¹ Woo C.J....Kingston R.E. (Cell 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus

Entrez Gene: 3237	HGNC: 5134	AceView: HOXD10andHOXD11	Ensembl:ENSG00000128713	euGenes: HUgn3237
ECgene: HOXD11	H-InvDB: HOXD11

(According to HUGE)
About This Section

TryGeneCards Plus

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus

Name	Description
PharmGKB entry for HOXD11	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for HOXD11	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for HOXD11 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

TryGeneCards Plus

Patent Information for HOXD11 gene:
Search GeneIP for patents involving HOXD11

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section

TryGeneCards Plus


	EMD Millipore genomic analysis products

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Enzyme Activity Assays/Reagents
	Browse ELISpot/FluoroSpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Luminex Assays
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Recombinant/Natural Proteins		Browse Stem Cell Products
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	OriGene Antibodies for HOXD11		OriGene RNAi products in human, mouse, rat for HOXD11
	Browse OriGene qPCR primer pairs and template standards		OriGene Protein Over-expression Lysate for HOXD11
	OriGene Custom Mass Spec		OriGene clones in human, mouse for HOXD11
	OriGene qSTAR qPCR primer pairs in human, mouse for HOXD11		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	OriGene ORF clones in mouse, rat for HOXD11		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for HOXD11		OriGene Custom Protein Services for HOXD11

	Block miRNA regulation of human, mouse, rat HOXD11 using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing HOXD11
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HOXD11		Predesigned siRNA for gene silencing in human, mouse, rat HOXD11
	QuantiFast Probe-based Assays in human, mouse, rat HOXD11		QuantiTect SYBR Green Assays in human, mouse, rat HOXD11
	PCR Arrays including human, mouse, rat HOXD11		Search Chromatin IP Primers for HOXD11
	Pre-validated RT² qPCR Primer Assay in human, mouse, rat HOXD11		Search GeneGlobe Interaction Network for HOXD11
	Regulatory tfbs in HOXD11 promoter

	GenScript Custom Purified and Recombinant Proteins Services for HOXD11		GenScript cDNA clones with any tag delivered in your preferred vector for HOXD11
	GenScript Custom Assay Services for HOXD11		GenScript Custom overexpressing Cell Line Services for HOXD11
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

Search for Antibodies & Assays

Search Tocris compounds for HOXD11 (HXD11)

	Browse Sino Biological Proteins
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	HOXD11 antibodies
	HOXD11 proteins
	HOXD11 lysates

	Antibodies for HOXD11
	See all of Abcam's Antibodies, Kits and Proteins for HOXD11
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for HOXD11
	Antibodies for HOXD11
	ELISAs for HOXD11
	CLIAs for HOXD11

Browse ESI BIO Cell Lines and PureStem Progenitors for HOXD11

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXD11

	SwitchGear 3'UTR luciferase reporter plasmids for HOXD11
	SwitchGear Promoter luciferase reporter plasmids for HOXD11

Search ThermoFisher Antibodies for HOXD11

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXD11

Browse compounds at ApexBio

Search Addgene for plasmids for HOXD11

	Search eBioscience for proteins for HOXD11
	Search eBioscience for elisas for HOXD11
	eBioscience FlowRNA Probe Sets

genOway: Develop your customized and physiologically relevant rodent model for HOXD11

	antibodies-online antibodies for HOXD11 (36 products)
	antibodies-online kits for HOXD11 (6 products)
	antibodies-online peptides for HOXD11
	antibodies-online proteins for HOXD11 (7 products)

GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 2 Nov 2014 , 8 Jan 2015

View Random Gene

Category			(GIFtS: )
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes HOXD11 gene at Home site.

Version: 3.12.304 29 Jan 2015
hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4

GeneCards Plus

Advanced Search

Export list of displayed genes

HOXD11 Gene

Homeobox D11

Aliases
for HOXD11 gene

Summaries
for HOXD11 gene

Genomic Views
for HOXD11 gene

Proteins
for HOXD11 gene

HOXD11 Human Recombinant Protein Products:

HOXD11 Antibody Products:

HOXD11 Assay Products:

Domains /
Families
for HOXD11 gene

Function
for HOXD11 gene

Localization
for HOXD11 gene

Pathways & Interactions
for HOXD11 gene

Drugs & Compounds
for HOXD11 gene

Transcripts
for HOXD11 gene

Expression
for HOXD11 gene

Orthologs
for HOXD11 gene

Paralogs
for HOXD11 gene

Genomic Variants
for HOXD11 gene

Disorders / Diseases
for HOXD11 gene

Publications
for HOXD11 gene

External Searches for HOXD11 gene

Genome Databases showing HOXD11 gene

Other Databases showing HOXD11 gene

Specialized Databases showing HOXD11 gene

Intellectual Property
for HOXD11 gene

Products
for HOXD11 gene

View Random Gene

GeneCards Plus

Advanced Search

Export list of displayed genes

HOXD11 Gene

Homeobox D11

Aliasesfor HOXD11 gene

Summariesfor HOXD11 gene

Genomic Viewsfor HOXD11 gene

Proteinsfor HOXD11 gene

HOXD11 Human Recombinant Protein Products:

HOXD11 Antibody Products:

HOXD11 Assay Products:

Domains /Familiesfor HOXD11 gene

Functionfor HOXD11 gene

Localizationfor HOXD11 gene

Pathways & Interactionsfor HOXD11 gene

Drugs & Compoundsfor HOXD11 gene

Transcriptsfor HOXD11 gene

Expression for HOXD11 gene

Orthologsfor HOXD11 gene

Paralogsfor HOXD11 gene

Genomic Variantsfor HOXD11 gene

Disorders / Diseasesfor HOXD11 gene

Publicationsfor HOXD11 gene

External Searches for HOXD11 gene

Genome Databases showing HOXD11 gene

Other Databases showing HOXD11 gene

Specialized Databases showing HOXD11 gene

Intellectual Propertyfor HOXD11 gene

Productsfor HOXD11 gene

View Random Gene

Aliases
for HOXD11 gene

Summaries
for HOXD11 gene

Genomic Views
for HOXD11 gene

Proteins
for HOXD11 gene

Domains /
Families
for HOXD11 gene

Function
for HOXD11 gene

Localization
for HOXD11 gene

Pathways & Interactions
for HOXD11 gene

Drugs & Compounds
for HOXD11 gene

Transcripts
for HOXD11 gene

Expression
for HOXD11 gene

Orthologs
for HOXD11 gene

Paralogs
for HOXD11 gene

Genomic Variants
for HOXD11 gene

Disorders / Diseases
for HOXD11 gene

Publications
for HOXD11 gene

Intellectual Property
for HOXD11 gene

Products
for HOXD11 gene