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Aliases for HOXD11 Gene

Aliases for HOXD11 Gene

  • Homeobox D11 2 3 5
  • Homeobox Protein Hox-4F 3 4
  • Homeo Box D11 2 3
  • HOX4F 3 4
  • Hox-4.6, Mouse, Homolog Of 3
  • Homeobox Protein Hox-D11 3
  • Homeo Box 4F 3
  • HOX4 3

External Ids for HOXD11 Gene

Previous HGNC Symbols for HOXD11 Gene

  • HOX4
  • HOX4F

Previous GeneCards Identifiers for HOXD11 Gene

  • GC02P175024
  • GC02P175633
  • GC02P176936
  • GC02P177174
  • GC02P176797
  • GC02P176680
  • GC02P168849

Summaries for HOXD11 Gene

Entrez Gene Summary for HOXD11 Gene

  • This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in forelimb morphogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXD11 Gene

HOXD11 (Homeobox D11) is a Protein Coding gene. Diseases associated with HOXD11 include Syndactyly, Type V and Synpolydactyly. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is HOXA11.

UniProtKB/Swiss-Prot for HOXD11 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Wiki entry for HOXD11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXD11 Gene

Genomics for HOXD11 Gene

Regulatory Elements for HOXD11 Gene

Enhancers for HOXD11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F176105 1 FANTOM5 19.7 +1.1 1135 0.4 INSM2 ZNF76 KLF17 FEZF1 ZEB1 GLIS2 ZNF366 KLF7 EGR2 SP3 HOXD11 HOXD13 HOXD10 HOXD9 HOXD8 HOXD3
GH02F176159 0.2 ENCODE 11.4 +57.0 56998 3.0 RNF2 MTA2 SUZ12 CBX2 FEZF1 ZIC2 TBX21 OSR2 CBX8 ZFHX2 HAGLROS HAGLR HOXD1 MIR7704 HOXD-AS2 HOXD9 HOXD3 HOXD8 HOXD10 HOXD11
GH02F176067 0.2 Ensembl 11 -36.7 -36716 0.2 HDGF ATF1 PKNOX1 ARNT FEZF1 ZNF2 ZNF766 GATA2 FOS YY2 HOXD13 HOXD12 HOXD11 EVX2 GC02M176020
GH02F176171 0.7 ENCODE 11 +67.2 67232 0.2 RNF2 CBX2 CTBP2 ZBTB40 HAGLROS HOXD-AS2 HOXD3 HOXD10 HOXD11 HOXD8 HOXD12 HOXD9 HOXD13 LOC105373753
GH02F176172 0.4 ENCODE 11 +67.7 67672 0.2 CTCF RNF2 SUZ12 CBX2 CTBP2 ZBTB40 EZH2 HOXD-AS2 HOXD3 HOXD10 HOXD11 HOXD8 HOXD12 HOXD9 HOXD13 LOC105373753 HAGLROS
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HOXD11 on UCSC Golden Path with GeneCards custom track

Genomic Location for HOXD11 Gene

Chromosome:
2
Start:
176,104,216 bp from pter
End:
176,109,754 bp from pter
Size:
5,539 bases
Orientation:
Plus strand

Genomic View for HOXD11 Gene

Genes around HOXD11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOXD11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOXD11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXD11 Gene

Proteins for HOXD11 Gene

  • Protein details for HOXD11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31277-HXD11_HUMAN
    Recommended name:
    Homeobox protein Hox-D11
    Protein Accession:
    P31277
    Secondary Accessions:
    • A6NIS4
    • Q9NS02

    Protein attributes for HOXD11 Gene

    Size:
    338 amino acids
    Molecular mass:
    35197 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXD11 Gene

Post-translational modifications for HOXD11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXD11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for HOXD11
  • Santa Cruz Biotechnology (SCBT) Antibodies for HOXD11

No data available for DME Specific Peptides for HOXD11 Gene

Domains & Families for HOXD11 Gene

Gene Families for HOXD11 Gene

Protein Domains for HOXD11 Gene

Suggested Antigen Peptide Sequences for HOXD11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P31277

UniProtKB/Swiss-Prot:

HXD11_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the Abd-B homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the Abd-B homeobox family.
genes like me logo Genes that share domains with HOXD11: view

Function for HOXD11 Gene

Molecular function for HOXD11 Gene

GENATLAS Biochemistry:
homeo box D11(4F),homologous to mouse Hox-4.6
UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Ontology (GO) - Molecular Function for HOXD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HOXD11: view
genes like me logo Genes that share phenotypes with HOXD11: view

Animal Models for HOXD11 Gene

MGI Knock Outs for HOXD11:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXD11 Gene

Localization for HOXD11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXD11 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOXD11 Gene COMPARTMENTS Subcellular localization image for HOXD11 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HOXD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with HOXD11: view

Pathways & Interactions for HOXD11 Gene

SuperPathways for HOXD11 Gene

No Data Available

SIGNOR curated interactions for HOXD11 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for HOXD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001658 branching involved in ureteric bud morphogenesis ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0009953 dorsal/ventral pattern formation ISS --
genes like me logo Genes that share ontologies with HOXD11: view

No data available for Pathways by source for HOXD11 Gene

Transcripts for HOXD11 Gene

mRNA/cDNA for HOXD11 Gene

Unigene Clusters for HOXD11 Gene

Homeobox D11:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOXD11 Gene

No ASD Table

Relevant External Links for HOXD11 Gene

GeneLoc Exon Structure for
HOXD11
ECgene alternative splicing isoforms for
HOXD11

Expression for HOXD11 Gene

mRNA expression in normal human tissues for HOXD11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXD11 Gene

This gene is overexpressed in Uterus (x13.3), Vagina (x9.7), Colon - Sigmoid (x9.5), Prostate (x5.8), Cervix - Ectocervix (x5.2), and Kidney - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for HOXD11 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HOXD11 Gene



Protein tissue co-expression partners for HOXD11 Gene

NURSA nuclear receptor signaling pathways regulating expression of HOXD11 Gene:

HOXD11

SOURCE GeneReport for Unigene cluster for HOXD11 Gene:

Hs.421136
genes like me logo Genes that share expression patterns with HOXD11: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for HOXD11 Gene

Orthologs for HOXD11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HOXD11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOXD11 34 35
  • 96.25 (n)
dog
(Canis familiaris)
Mammalia HOXD11 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HOXD 35
  • 95 (a)
OneToOne
HOXD11 34
  • 91.37 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 88 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Hoxd11 34 16 35
  • 87.2 (n)
oppossum
(Monodelphis domestica)
Mammalia HOXD11 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves HOXD11 34 35
  • 72.5 (n)
lizard
(Anolis carolinensis)
Reptilia HOXD11 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxd11 34
  • 65.33 (n)
zebrafish
(Danio rerio)
Actinopterygii hoxd11a 34 35
  • 58.91 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 12 (a)
OneToMany
Species where no ortholog for HOXD11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXD11 Gene

ENSEMBL:
Gene Tree for HOXD11 (if available)
TreeFam:
Gene Tree for HOXD11 (if available)

Paralogs for HOXD11 Gene

(13) SIMAP similar genes for HOXD11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HOXD11: view

Variants for HOXD11 Gene

Sequence variations from dbSNP and Humsavar for HOXD11 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs111816201 -- 176,107,760(+) GGCCG(C/G)CGGCC upstream-variant-2KB, reference, synonymous-codon
rs112003616 -- 176,108,061(+) CCAAG(A/G)GGGCA upstream-variant-2KB, reference, missense
rs113128957 -- 176,108,185(+) GGGGA(-/G)GGGGG intron-variant, upstream-variant-2KB
rs113696385 -- 176,107,240(+) TCAGC(G/T)CCCGG upstream-variant-2KB
rs113837647 -- 176,107,086(+) CAGAG(G/T)GCAGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HOXD11 Gene

Variant ID Type Subtype PubMed ID
dgv676n67 CNV gain 20364138
dgv7173n54 CNV loss 21841781
nsv1072996 CNV deletion 25765185
nsv1112777 CNV deletion 24896259
nsv1126572 CNV deletion 24896259
nsv517968 CNV loss 19592680
nsv520227 CNV loss 19592680
nsv524250 CNV loss 19592680
nsv527187 CNV loss 19592680
nsv583673 CNV loss 21841781

Variation tolerance for HOXD11 Gene

Gene Damage Index Score: 1.42; 27.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HOXD11 Gene

Human Gene Mutation Database (HGMD)
HOXD11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HOXD11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXD11 Gene

Disorders for HOXD11 Gene

MalaCards: The human disease database

(4) MalaCards diseases for HOXD11 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
syndactyly, type v
  • syndactyly type 5
synpolydactyly
  • synpolydactyly 1
brachydactyly-syndactyly syndrome
  • brachydactyly-syndactyly, zhao type
renal hypodysplasia/aplasia 1
  • renal agenesis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HOXD11

Genetic Association Database (GAD)
HOXD11
Human Genome Epidemiology (HuGE) Navigator
HOXD11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HOXD11
genes like me logo Genes that share disorders with HOXD11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HOXD11 Gene

Publications for HOXD11 Gene

  1. Study of HOXD genes in autism particularly regarding the ratio of second to fourth digit length. (PMID: 19540081) Sugie Y. … Osawa J. (Brain Dev. 2010) 3 46 64
  2. Absence of mutations in the HOXA11 and HOXD11 genes in children with congenital renal malformations. (PMID: 19255789) Bouba I. … Georgiou I. (Pediatr. Nephrol. 2009) 3 46 64
  3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 46 64
  4. Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot. (PMID: 19938081) Ester A.R. … Hecht J.T. (Am. J. Med. Genet. A 2009) 3 46 64
  5. Mutations in HOXD13 underlie syndactyly type V and a novel brachydactyly-syndactyly syndrome. (PMID: 17236141) Zhao X. … Zhang X. (Am. J. Hum. Genet. 2007) 3 4 64

Products for HOXD11 Gene

Sources for HOXD11 Gene

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