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HOXD11 Gene

protein-coding   GIFtS: 51
GCID: GC02P176936

Homeobox D11

(Previous name: homeo box D11)
(Previous symbols: HOX4, HOX4F)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Homeobox D111 2     Homeobox Protein Hox-4F2 3
HOX4F1 2 3 5     Homeo Box 4F2
HOX41 2     Homeobox Protein Hox-D112
Homeo Box D111 2     Hox-4.6, Mouse, Homolog Of2

External Ids:    HGNC: 51341   Entrez Gene: 32372   Ensembl: ENSG000001287137   OMIM: 1429865   UniProtKB: P312773   

Export aliases for HOXD11 gene to outside databases

Previous GC identifers: GC02P175024 GC02P175633 GC02P177174 GC02P176797 GC02P176680 GC02P168849


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HOXD11 Gene:
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of
transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals
possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes,
consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a
cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have
been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in
forelimb morphogenesis. (provided by RefSeq, Jul 2008)

GeneCards Summary for HOXD11 Gene:
HOXD11 (homeobox D11) is a protein-coding gene. Diseases associated with HOXD11 include brachydactyly-syndactyly syndrome, and brachydactyly. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ENSG00000257184.

UniProtKB/Swiss-Prot: HXD11_HUMAN, P31277
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXD11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HOXD11 gene promoter:
         E2F-4   E2F-3a   PPAR-gamma1   E2F-2   Nkx2-5   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHOXD11 promoter sequence
   Search Chromatin IP Primers for HOXD11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HOXD11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

HOXD11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXD11 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P176936:  view genomic region     (about GC identifiers)

Start:
176,968,944 bp from pter      End:
176,974,722 bp from pter
Size:
5,779 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HXD11_HUMAN, P31277 (See protein sequence)
Recommended Name: Homeobox protein Hox-D11  
Size: 338 amino acids; 35197 Da
Secondary accessions: A6NIS4 Q9NS02

Explore the universe of human proteins at neXtProt for HOXD11: NX_P31277

Explore proteomics data for HOXD11 at MOPED


See HOXD11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_067015.2  
ENSEMBL proteins: 
 ENSP00000249504  

HOXD11 Human Recombinant Protein Products:

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Cloud-Clone Corp. CLIAs for HOXD11


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
HOXL: Homeoboxes / ANTP class : HOXL subclass

5 InterPro protein domains:
 IPR021918 DUF3528
 IPR020479 Homeobox_metazoa
 IPR017970 Homeobox_CS
 IPR001356 Homeobox_dom
 IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry P31277

ProtoNet protein and cluster: P31277

UniProtKB/Swiss-Prot: HXD11_HUMAN, P31277
Similarity: Belongs to the Abd-B homeobox family
Similarity: Contains 1 homeobox DNA-binding domain


HOXD11 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: HXD11_HUMAN, P31277
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
cells with specific positional identities on the anterior-posterior axis

     Genatlas biochemistry entry for HOXD11:
homeo box D11(4F),homologous to mouse Hox-4.6

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding ----
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
GO:0043565sequence-specific DNA binding IEA--
     
HOXD11 for ontologies           About GeneDecksing


Phenotypes:
     9 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Hoxd11):
 cellular  embryogenesis  limbs/digits/tail  mortality/aging  nervous system 
 no phenotypic analysis  renal/urinary system  reproductive system  skeleton 

HOXD11 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for HOXD11: Evx2/Hoxd11/Hoxd12/Hoxd13Evx2/Hoxd11/Hoxd12/tm1Ddu Hoxd11tm2.1Ddu Hoxd11tm1Mrc Hoxd11tm2Ddu Hoxd11tm1Ipc

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HOXD11
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HOXD11

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HOXD11
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HOXD11

miRNA
Products:
    
miRTarBase miRNAs that target HOXD11:
hsa-let-7b-5p (MIRT051956), hsa-mir-744-5p (MIRT037516)

Block miRNA regulation of human, mouse, rat HOXD11 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate HOXD11
SwitchGear 3'UTR luciferase reporter plasmidHOXD11 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat HOXD11

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GenScript: all cDNA clones in your preferred vector: HOXD11 (NM_021192)
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXD11


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
HXD11_HUMAN, P31277: Nucleus
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

HOXD11 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Pathway & Disease-focused RT2 Profiler PCR Array including HOXD11: 
          Homeobox (HOX) Genes in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for HOXD11

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

Selected Interacting proteins for HOXD11 (P312773 ENSP000002495044) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
InteractantInteraction Details
GeneCardExternal ID(s)
MEIS1O004703, ENSP000002723694I2D: score=1 STRING: ENSP00000272369
HMGB1P094293, ENSP000003430404I2D: score=1 STRING: ENSP00000343040
MEIS2ENSP000003262964STRING: ENSP00000326296
GMNNENSP000002300564STRING: ENSP00000230056
LINSENSP000003184234STRING: ENSP00000318423
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Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001501skeletal system development ----
GO:0001656metanephros development IEA--
GO:0001658branching involved in ureteric bud morphogenesis ISS--
GO:0001759organ induction IEA--
GO:0006351transcription, DNA-templated IEA--

HOXD11 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for HOXD11 (HXD11)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for HOXD11 gene: 
NM_021192.2  

Unigene Cluster for HOXD11:

Homeobox D11
Hs.421136  [show with all ESTs]
Unigene Representative Sequence: NM_021192
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000498438(uc010fqx.3) ENST00000249504(uc002uki.3)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat HOXD11 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate HOXD11
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Inhib. RNA
Products:
     
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Predesigned siRNA for gene silencing in human, mouse, rat HOXD11
Clone
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GenScript: all cDNA clones in your preferred vector: HOXD11 (NM_021192)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXD11
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXD11
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for HOXD11
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HOXD11
  QuantiTect SYBR Green Assays in human, mouse, rat HOXD11
  QuantiFast Probe-based Assays in human, mouse, rat HOXD11

Additional mRNA sequence: 

AK309681.1 BC109394.1 

4 DOTS entries:

DT.70105486  DT.97771570  DT.408703  DT.100707782 

Selected AceView cDNA sequences (see all 56):

BC074760 NM_002148 AI139039 AI095929 AW205221 AA653427 NM_021192 BF510955 
BC069619 AW206798 BX114645 X59373 AA442532 AA479366 BF680250 AI277208 
BF526767 AW194680 CA431276 AW195017 AW630600 AI423516 CD614162 BX117343 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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HOXD11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CAACGCGAGC
HOXD11 Expression
About this image


HOXD11 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 11) fully expand
 
 Kidney (Urinary System)    fully expand to see all 6 entries
         Metanephric Mesenchyme Cells Metanephric Mesenchyme
         Metanephros
         mK3
         Intermediate mesoderm derivatives
 
 Limb (Muscoskeletal System)    fully expand to see all 4 entries
         Limb Bud Mesenchyme Cells Limb Bud
         Limb Bud
 
 Bone (Muscoskeletal System)    fully expand to see all 3 entries
         Sacral Sclerotome Cells Sacral Mesenchymal Sclerotome
         Zeugopod Long Bone
 
 Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
         Limb Bud Mesenchyme Cells Limb Bud
 
 Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
         Sacral Sclerotome Cells Sacral Mesenchymal Sclerotome
HOXD11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

HOXD11 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.421136
    Pathway & Disease-focused RT2 Profiler PCR Array including HOXD11: 
          Homeobox (HOX) Genes in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for HOXD11
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXD11

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for HOXD11 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Hoxd111 , 5 homeobox D111, 5 87.2(n)1
89.88(a)1
  2 (44.13 cM)5
154311  NM_008273.21  NP_032299.11 
 746793925 
chicken
(Gallus gallus)
Aves HOXD111 homeobox D11 72.5(n)
71.79(a)
  395328  NM_204620.1  NP_989951.1 
lizard
(Anolis carolinensis)
Reptilia HOXD116
homeobox D11
63(a)
1 ↔ 1
GL343356.1(556257-559822)
tropical clawed frog
(Xenopus tropicalis)
Amphibia hoxd111 homeobox D11 65.33(n)
64.96(a)
  100497945  XM_002935676.2  XP_002935722.1 
zebrafish
(Danio rerio)
Actinopterygii hoxd11a1 homeo box D11a 58.91(n)
56(a)
  30405  NM_131167.1  NP_571242.1 


ENSEMBL Gene Tree for HOXD11 (if available)
TreeFam Gene Tree for HOXD11 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for HOXD11 gene
ENSG000002571842  HOXD102  HOXC132  HOXC102  HOXD122  HOXA92  HOXA132  HOXC92  
HOXB132  HOXC122  HOXC112  HOXD132  HOXA112  HOXB92  HOXD92  HOXA102  
13 SIMAP similar genes for HOXD11 using alignment to 2 protein entries:     HXD11_HUMAN (see all proteins):
CDX1    HOX B6    HOXC13    HOXB1    HOXA4    HOXB8
HOXA-9    HOXA11    HOXB3    HOXD13    GBX1    HOXC11
HOXA10

HOXD11 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for HOXD11 (see all 96)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1888961351,2
--176970117(+) AAGGGG/TCGGAG 1 -- us2k10--------
rs1164253451,2
C,F--176970121(+) GGCGGA/GGGAAG 1 -- us2k11Minor allele frequency- G:0.06WA 118
rs2018287651,2
C--176970168(+) AGGAA-/GGGGGG 1 -- us2k10--------
rs1172576371,2
C,F--176970185(+) CAGCCA/GGAAAA 1 -- us2k11Minor allele frequency- G:0.02EA 120
rs729234361,2
C,F--176970247(+) CAGAGC/AGCACA 1 -- us2k12Minor allele frequency- A:0.07WA NA 238
rs38138111,2
C,F,H--176970340(-) CTGGGG/ACCTGG 1 -- us2k14Minor allele frequency- A:0.01NS EA 418
rs730337201,2
C,F--176970401(+) CCCTCG/TGTTCT 1 -- us2k12Minor allele frequency- T:0.06WA 120
rs8471481,2
C,F,H--176970456(-) CCGAGT/AGAGCA 1 -- us2k116Minor allele frequency- A:0.29NS EA NA WA CSA 791
rs8471471,2
C,F,A,H--176970659(-) TCAGCC/TCCTCC 1 -- us2k1 tfbs3 trp323Minor allele frequency- T:0.26MN NS EA NA WA CSA 2417
rs803407311,2
C,F--176970735(+) TTGGCG/CGGGCT 1 -- us2k12Minor allele frequency- C:0.04CSA WA 119

HapMap Linkage Disequilibrium report for HOXD11 (176968944 - 176974722 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for HOXD11 (see all 13):    About this table    
Variant IDTypeSubtypePubMed ID
nsv520227CNV Loss19592680
nsv875441CNV Loss21882294
nsv875447CNV Loss21882294
nsv875442CNV Loss21882294
dgv4368n71CNV Loss21882294
nsv524250CNV Loss19592680
nsv875438CNV Loss21882294
nsv875446CNV Loss21882294
nsv875437CNV Loss21882294
dgv4369n71CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing HOXD11
DNA2.0 Custom Variant and Variant Library Synthesis for HOXD11

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 142986    OMIM disorders: --

10 diseases for HOXD11:    
About MalaCards
brachydactyly-syndactyly syndrome    brachydactyly    syndactyly    clubfoot
renal agenesis    polydactyly    acute myeloid leukemia    myeloid leukemia
leukemia    endotheliitis

2 diseases from the University of Copenhagen DISEASES database for HOXD11:
Polydactyly     Renal agenesis

HOXD11 for disorders           About GeneDecksing

Genetic Association Database (GAD): HOXD11
Human Genome Epidemiology (HuGE) Navigator: HOXD11 (5 documents)

Export disorders for HOXD11 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for HOXD11 gene, integrated from 10 sources (see all 33):
(articles sorted by number of sources associating them with HOXD11)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Study of HOXD genes in autism particularly regarding the ratio of second to fourth digit length. (PubMed id 19540081)1, 4 Sugie Y....Osawa J. (amp 2010)
  2. Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot. (PubMed id 19938081)1, 4 Ester A.R....Hecht J.T. (Am. J. Med. Genet. A 2009)
  3. Absence of mutations in the HOXA11 and HOXD11 genes in children with congenital renal malformations. (PubMed id 19255789)1, 4 Bouba I....Georgiou I. (Pediatr. Nephrol. 2009)
  4. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
  5. Mutations in HOXD13 underlie syndactyly type V and a novel brachydactyly-syndactyly syndrome. (PubMed id 17236141)1, 2 Zhao X.... Zhang X. (Am. J. Hum. Genet. 2007)
  6. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (Cell 1992)
  7. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (Genomics 1990)
  8. The human HOX gene family. (PubMed id 2574852)1, 2 Acampora D.... Boncinelli E. (Nucleic Acids Res. 1989)
  9. The HOXD11 gene is fused to the NUP98 gene in acute myeloid leukemia with t(2;11)(q31;p15). (PubMed id 11782354)1, 9 Taketani T....Hayashi Y. (Cancer Res. 2002)
  10. A region of the human HOXD cluster that confers polycomb-group responsiveness. (PubMed id 20085705)1 Woo C.J....Kingston R.E. (Cell 2010)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3237 HGNC: 5134 AceView: HOXD10andHOXD11 Ensembl:ENSG00000128713 euGenes: HUgn3237
ECgene: HOXD11 H-InvDB: HOXD11

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for HOXD11 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for HOXD11 Genetics and Cytogenetics in Oncology and Haematology

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Patent Information for HOXD11 gene:
Search GeneIP for patents involving HOXD11

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