Aliases for HOXD11 Gene
Aliases for HOXD11 Gene
External Ids for HOXD11 Gene
- HGNC: 5134
- Entrez Gene: 3237
- Ensembl: ENSG00000128713
- OMIM: 142986
- UniProtKB: P31277
Previous HGNC Symbols for HOXD11 Gene
- HOX4
- HOX4F
Previous GeneCards Identifiers for HOXD11 Gene
- GC02P175024
- GC02P175633
- GC02P176936
- GC02P177174
- GC02P176797
- GC02P176680
- GC02P168849
Summaries for HOXD11 Gene
-
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in forelimb morphogenesis. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOXD11 Gene
HOXD11 (Homeobox D11) is a Protein Coding gene. Diseases associated with HOXD11 include Syndactyly, Type V and Synpolydactyly. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is HOXA11.
UniProtKB/Swiss-Prot for HOXD11 Gene
-
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Additional gene information for HOXD11 Gene
- Monarch Initiative
- Search for HOXD11 at DataMed
- Search for HOXD11 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXD11 Gene
Genomics for HOXD11 Gene
GeneHancer (GH) Regulatory Elements for HOXD11 Gene
- Top Transcription factor binding sites by QIAGEN in the HOXD11 gene promoter:
Regulatory Element Products
Genomic Locations for HOXD11 Gene
- chr2:176,104,216-176,109,754
- (GRCh38/hg38)
- Size:
- 5,539 bases
- Orientation:
- Plus strand
- chr2:176,968,944-176,974,722
- (GRCh37/hg19)
Genomic View for HOXD11 Gene
- Cytogenetic band:
-
- 2q31.1 by Ensembl
- 2q31.1 by Entrez Gene
- 2q31.1 by HGNC


RefSeq DNA sequence for HOXD11 Gene
Proteins for HOXD11 Gene
-
Protein details for HOXD11 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P31277-HXD11_HUMAN
- Recommended name:
- Homeobox protein Hox-D11
- Protein Accession:
- P31277
- A6NIS4
- Q9NS02
Protein attributes for HOXD11 Gene
- Size:
- 338 amino acids
- Molecular mass:
- 35197 Da
- Quaternary structure:
- No Data Available
Protein Expression for HOXD11 Gene
Post-translational modifications for HOXD11 Gene
Other Protein References for HOXD11 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
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-
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Assay Products
No data available for DME Specific Peptides for HOXD11 Gene
Domains & Families for HOXD11 Gene
Gene Families for HOXD11 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for HOXD11 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HOXD11 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P31277- Family:
-
- Belongs to the Abd-B homeobox family.
Function for HOXD11 Gene
Molecular function for HOXD11 Gene
- GENATLAS Biochemistry:
- homeo box D11(4F),homologous to mouse Hox-4.6
- UniProtKB/Swiss-Prot Function:
- Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Phenotypes From GWAS Catalog for HOXD11 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IEA | -- |
GO:0043565 | sequence-specific DNA binding | IEA | -- |
Phenotypes for HOXD11 Gene
- MGI mutant phenotypes for HOXD11:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for HOXD11:
Animal Models for HOXD11 Gene
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miRNA for HOXD11 Gene
- miRTarBase miRNAs that target HOXD11
-
- hsa-mir-744-5p (MIRT037516)
- hsa-let-7b-5p (MIRT051956)
- hsa-mir-10b-5p (MIRT439125)
- hsa-mir-3674 (MIRT557015)
- hsa-mir-27b-3p (MIRT557016)
- hsa-mir-27a-3p (MIRT557017)
- hsa-mir-513a-5p (MIRT557018)
- hsa-mir-5701 (MIRT557019)
- hsa-mir-4326 (MIRT557020)
- hsa-mir-205-3p (MIRT557021)
- hsa-mir-454-3p (MIRT557022)
- hsa-mir-4295 (MIRT557023)
- hsa-mir-3666 (MIRT557024)
- hsa-mir-301b-3p (MIRT557025)
- hsa-mir-301a-3p (MIRT557026)
- hsa-mir-130b-3p (MIRT557027)
- hsa-mir-130a-3p (MIRT557028)
- hsa-mir-32-3p (MIRT557029)
- hsa-mir-93-5p (MIRT557030)
- hsa-mir-106a-5p (MIRT557031)
- hsa-mir-106b-5p (MIRT557032)
- hsa-mir-17-5p (MIRT557033)
- hsa-mir-20b-5p (MIRT557034)
- hsa-mir-519d-3p (MIRT557035)
- hsa-mir-526b-3p (MIRT557036)
- hsa-mir-20a-5p (MIRT557037)
- hsa-mir-129-5p (MIRT616267)
- hsa-mir-450a-5p (MIRT616268)
- hsa-mir-6887-5p (MIRT616269)
- hsa-mir-6795-5p (MIRT616270)
- hsa-mir-6870-5p (MIRT616271)
- hsa-mir-7111-5p (MIRT616272)
- hsa-mir-5698 (MIRT616273)
- hsa-mir-4723-5p (MIRT616274)
- hsa-mir-4706 (MIRT616275)
- hsa-mir-4749-5p (MIRT616276)
- hsa-mir-329-5p (MIRT616277)
miRNA Products
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-
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- Mammalian expression: PiggyBac
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- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available HOXD11 gene related products
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-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXD11 Gene
Localization for HOXD11 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HOXD11 Gene
- Nucleus.
- Nucleoplasm (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | IDA | -- |
Pathways & Interactions for HOXD11 Gene
Interacting Proteins for HOXD11 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001658 | branching involved in ureteric bud morphogenesis | ISS | -- |
GO:0006351 | transcription, DNA-templated | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0007275 | multicellular organism development | IEA | -- |
GO:0009953 | dorsal/ventral pattern formation | ISS | -- |
No data available for Pathways by source for HOXD11 Gene
Transcripts for HOXD11 Gene
mRNA/cDNA for HOXD11 Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (56) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HOXD11
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Vectors and viruses for KO, Activation, Repression, and more
-
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Inhibitory RNA Products
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-
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available HOXD11 gene related products
- orf clones - Search results for available HOXD11 gene related products
- Applied Biological Materials Clones for HOXD11
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for HOXD11 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Prechondrocytic Mesenchymal Cells Dorsal Neural Arch
- Sclerotome Cells Sacral Mesenchymal Sclerotome
- Prechondrocytic Mesenchymal Cells Lateral Neural Arch
- Prechondrocytic Mesenchymal Cells Spinous Process Of Vertebrae
- Prechondrocytic Mesenchymal Cells Central Neural Arch
-
Cartilage (Muscoskeletal System)
- Prechondrocytic Mesenchymal Cells Dorsal Neural Arch
- Sclerotome Cells Sacral Mesenchymal Sclerotome
- Prechondrocytic Mesenchymal Cells Lateral Neural Arch
- Prechondrocytic Mesenchymal Cells Spinous Process Of Vertebrae
- Prechondrocytic Mesenchymal Cells Central Neural Arch
-
Kidney (Urinary System)
- Metanephric Mesenchyme Cells Metanephric Mesenchyme
- Metanephros
- mK4
- mK3
- Renal progenitor cells(Takasato M et. al. 2014)
-
Limb (Muscoskeletal System)
- Zone Of Polarizing Activity Cells Limb Bud
- Prechondrocytic Mesenchymal Cells Zeugopod
- Limb Bud Mesenchyme Cells Limb Bud
- Limb Bud
-
Mesoderm (Gastrulation Derivatives)
- Zone Of Polarizing Activity Cells Limb Bud
- Limb Bud Mesenchyme Cells Limb Bud
- Mesenchymal Stem Cells (Uncategorized)
- Placenta (Extraembryonic Tissues)
-
Somite (Muscoskeletal System)
- Sclerotome Cells Sacral Mesenchymal Sclerotome
-
Tendon amp Ligament
- Sclerotome Cells Sacral Mesenchymal Sclerotome
- Eye (Sensory Organs)
- NULL (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for HOXD11 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HOXD11 Gene
NURSA nuclear receptor signaling pathways regulating expression of HOXD11 Gene:
HOXD11SOURCE GeneReport for Unigene cluster for HOXD11 Gene:
Hs.421136Evidence on tissue expression from TISSUES for HOXD11 Gene
- Kidney(2.5)
- Stomach(2.5)
- Muscle(2.2)
- Nervous system(2.2)
- Heart(2.1)
Primer Products
-
OriGene qPCR primer pairs for HOXD11
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No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXD11 Gene
Orthologs for HOXD11 Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | HOXD11 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | HOXD11 34 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | HOXD 34 |
|
OneToOne | |
HOXD11 33 |
|
||||
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
mouse (Mus musculus) |
Mammalia | Hoxd11 33 16 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | HOXD11 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | HOXD11 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | HOXD11 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | hoxd11 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | hoxd11a 33 34 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for HOXD11 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HOXD11 Gene
Paralogs for HOXD11 Gene
(13) SIMAP similar genes for HOXD11 Gene using alignment to 2 proteins:
Variants for HOXD11 Gene
SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000374466 | -- | 176,108,138(+) | T/G | splice_donor_variant | |
rs1000419816 | -- | 176,108,730(+) | C/T | intron_variant | |
rs1000580695 | -- | 176,109,113(+) | C/G | coding_sequence_variant, missense_variant | |
rs1001720766 | -- | 176,109,059(+) | A/C | coding_sequence_variant, missense_variant | |
rs1001926822 | -- | 176,108,306(+) | G/A/C | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv676n67 | CNV | gain | 20364138 |
dgv7173n54 | CNV | loss | 21841781 |
nsv1072996 | CNV | deletion | 25765185 |
nsv1112777 | CNV | deletion | 24896259 |
nsv1126572 | CNV | deletion | 24896259 |
nsv517968 | CNV | loss | 19592680 |
nsv520227 | CNV | loss | 19592680 |
nsv524250 | CNV | loss | 19592680 |
nsv527187 | CNV | loss | 19592680 |
nsv583673 | CNV | loss | 21841781 |
Additional Variant Information for HOXD11 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXD11 Gene
Disorders for HOXD11 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
syndactyly, type v |
|
|
synpolydactyly |
|
|
brachydactyly-syndactyly syndrome |
|
|
fraser syndrome 1 |
|
|
chromosome 2q35 duplication syndrome |
|
|
Additional Disease Information for HOXD11
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for HOXD11 Gene
Publications for HOXD11 Gene
- Study of HOXD genes in autism particularly regarding the ratio of second to fourth digit length. (PMID: 19540081) Sugie Y … Osawa J (Brain & development 2010) 3 44 58
- Absence of mutations in the HOXA11 and HOXD11 genes in children with congenital renal malformations. (PMID: 19255789) Bouba I … Georgiou I (Pediatric nephrology (Berlin, Germany) 2009) 3 44 58
- High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges LM … MrOS Research Group (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009) 3 44 58
- Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot. (PMID: 19938081) Ester AR … Hecht JT (American journal of medical genetics. Part A 2009) 3 44 58
- Mutations in HOXD13 underlie syndactyly type V and a novel brachydactyly-syndactyly syndrome. (PMID: 17236141) Zhao X … Zhang X (American journal of human genetics 2007) 3 4 58
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- Mammalian expression: PiggyBac
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- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
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- antibodies-online: Search results for 60 available HOXD11 Antibodies ranked by validation data
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Sources for HOXD11 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
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