Aliases for HOXD11 Gene
Aliases for HOXD11 Gene
External Ids for HOXD11 Gene
- HGNC: 5134
- Entrez Gene: 3237
- Ensembl: ENSG00000128713
- OMIM: 142986
- UniProtKB: P31277
Previous HGNC Symbols for HOXD11 Gene
- HOX4
- HOX4F
Previous GeneCards Identifiers for HOXD11 Gene
- GC02P175024
- GC02P175633
- GC02P176936
- GC02P177174
- GC02P176797
- GC02P176680
- GC02P168849
Summaries for HOXD11 Gene
-
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in forelimb morphogenesis. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOXD11 Gene
HOXD11 (Homeobox D11) is a Protein Coding gene. Diseases associated with HOXD11 include Syndactyly, Type V and Synpolydactyly. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is HOXA11.
UniProtKB/Swiss-Prot for HOXD11 Gene
-
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXD11 Gene
Genomics for HOXD11 Gene
Regulatory Elements for HOXD11 Gene
Enhancers for HOXD11 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HOXD11 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HOXD11 gene promoter:
Regulatory Element Products
Genomic Location for HOXD11 Gene
- Chromosome:
- 2
- Start:
- 176,104,216 bp from pter
- End:
- 176,109,754 bp from pter
- Size:
- 5,539 bases
- Orientation:
- Plus strand
Genomic View for HOXD11 Gene
Genes around HOXD11 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q31.1 by Ensembl
- 2q31.1 by Entrez Gene
- 2q31.1 by HGNC
HOXD11 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HOXD11 Gene
Proteins for HOXD11 Gene
-
Protein details for HOXD11 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P31277-HXD11_HUMAN
- Recommended name:
- Homeobox protein Hox-D11
- Protein Accession:
- P31277
- A6NIS4
- Q9NS02
Protein attributes for HOXD11 Gene
- Size:
- 338 amino acids
- Molecular mass:
- 35197 Da
- Quaternary structure:
- No Data Available
Protein Expression for HOXD11 Gene
Post-translational modifications for HOXD11 Gene
Other Protein References for HOXD11 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for HOXD11
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-
Abcam antibodies for HOXD11
- Invitrogen Antibodies for HOXD11
- antibodies-online Antibodies for HOXD11: See all 52
- GeneTex HOXD11 antibody for HOXD11
-
Santa Cruz Biotechnology (SCBT) Antibodies for HOXD11
Protein Products
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OriGene Purified Proteins for HOXD11
- Search Origene for MassSpec and Protein Over-expression Lysates for HOXD11
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- antibodies-online Proteins for HOXD11: See all 7
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HOXD11
-
Abcam proteins for HOXD11
No data available for DME Specific Peptides for HOXD11 Gene
Domains & Families for HOXD11 Gene
Gene Families for HOXD11 Gene
Protein Domains for HOXD11 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HOXD11 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P31277- Family:
-
- Belongs to the Abd-B homeobox family.
Function for HOXD11 Gene
Molecular function for HOXD11 Gene
- GENATLAS Biochemistry:
- homeo box D11(4F),homologous to mouse Hox-4.6
- UniProtKB/Swiss-Prot Function:
- Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0043565 | sequence-specific DNA binding | IEA | -- |
Phenotypes for HOXD11 Gene
- MGI mutant phenotypes for HOXD11:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for HOXD11:
Animal Models for HOXD11 Gene
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXD11 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for HOXD11
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXD11
- GenScript: Design CRISPR guide RNA sequences for HOXD11
miRNA for HOXD11 Gene
- miRTarBase miRNAs that target HOXD11
-
- hsa-mir-744-5p (MIRT037516)
- hsa-let-7b-5p (MIRT051956)
- hsa-mir-10b-5p (MIRT439125)
- hsa-mir-3674 (MIRT557015)
- hsa-mir-27b-3p (MIRT557016)
- hsa-mir-27a-3p (MIRT557017)
- hsa-mir-513a-5p (MIRT557018)
- hsa-mir-5701 (MIRT557019)
- hsa-mir-4326 (MIRT557020)
- hsa-mir-205-3p (MIRT557021)
- hsa-mir-454-3p (MIRT557022)
- hsa-mir-4295 (MIRT557023)
- hsa-mir-3666 (MIRT557024)
- hsa-mir-301b-3p (MIRT557025)
- hsa-mir-301a-3p (MIRT557026)
- hsa-mir-130b-3p (MIRT557027)
- hsa-mir-130a-3p (MIRT557028)
- hsa-mir-32-3p (MIRT557029)
- hsa-mir-93-5p (MIRT557030)
- hsa-mir-106a-5p (MIRT557031)
- hsa-mir-106b-5p (MIRT557032)
- hsa-mir-17-5p (MIRT557033)
- hsa-mir-20b-5p (MIRT557034)
- hsa-mir-519d-3p (MIRT557035)
- hsa-mir-526b-3p (MIRT557036)
- hsa-mir-20a-5p (MIRT557037)
- hsa-mir-129-5p (MIRT616267)
- hsa-mir-450a-5p (MIRT616268)
- hsa-mir-6887-5p (MIRT616269)
- hsa-mir-6795-5p (MIRT616270)
- hsa-mir-6870-5p (MIRT616271)
- hsa-mir-7111-5p (MIRT616272)
- hsa-mir-5698 (MIRT616273)
- hsa-mir-4723-5p (MIRT616274)
- hsa-mir-4706 (MIRT616275)
- hsa-mir-4749-5p (MIRT616276)
- hsa-mir-329-5p (MIRT616277)
miRNA Products
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Inhibitory RNA Products
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for HOXD11
-
ViGene Biosciences adenoviral particle packaged cDNA for HOXD11 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXD11 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXD11 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXD11 Gene
Localization for HOXD11 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HOXD11 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
Pathways & Interactions for HOXD11 Gene
No Data Available
Interacting Proteins for HOXD11 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001658 | branching involved in ureteric bud morphogenesis | ISS | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0009953 | dorsal/ventral pattern formation | ISS | -- |
No data available for Pathways by source for HOXD11 Gene
Transcripts for HOXD11 Gene
mRNA/cDNA for HOXD11 Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (56) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HOXD11
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXD11
- GenScript: Design CRISPR guide RNA sequences for HOXD11
miRNA Products
- Search ViGene Biosciences for HOXD11
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HOXD11
- Browse OriGene Inhibitory RNA Products For HOXD11
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXD11 gene
Clone Products
-
OriGene ORF clones in human for HOXD11
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for HOXD11
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HOXD11
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for HOXD11 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Prechondrocytic Mesenchymal Cells Dorsal Neural Arch
- Sclerotome Cells Sacral Mesenchymal Sclerotome
- Prechondrocytic Mesenchymal Cells Lateral Neural Arch
- Prechondrocytic Mesenchymal Cells Spinous Process Of Vertebrae
- Prechondrocytic Mesenchymal Cells Central Neural Arch
-
Cartilage (Muscoskeletal System)
- Prechondrocytic Mesenchymal Cells Dorsal Neural Arch
- Sclerotome Cells Sacral Mesenchymal Sclerotome
- Prechondrocytic Mesenchymal Cells Lateral Neural Arch
- Prechondrocytic Mesenchymal Cells Spinous Process Of Vertebrae
- Prechondrocytic Mesenchymal Cells Central Neural Arch
-
Kidney (Urinary System)
- Metanephric Mesenchyme Cells Metanephric Mesenchyme
- Metanephros
- mK4
- mK3
- Renal progenitor cells(Takasato M et. al. 2014)
-
Limb (Muscoskeletal System)
- Zone Of Polarizing Activity Cells Limb Bud
- Prechondrocytic Mesenchymal Cells Zeugopod
- Limb Bud Mesenchyme Cells Limb Bud
- Limb Bud
-
Mesoderm (Gastrulation Derivatives)
- Zone Of Polarizing Activity Cells Limb Bud
- Limb Bud Mesenchyme Cells Limb Bud
- Mesenchymal Stem Cells (Uncategorized)
- Placenta (Extraembryonic Tissues)
-
Somite (Muscoskeletal System)
- Sclerotome Cells Sacral Mesenchymal Sclerotome
-
Tendon amp Ligament
- Sclerotome Cells Sacral Mesenchymal Sclerotome
- Eye (Sensory Organs)
- NULL (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for HOXD11 Gene
This gene is overexpressed in Uterus (x13.3), Vagina (x9.7), Colon - Sigmoid (x9.5), Prostate (x5.8), Cervix - Ectocervix (x5.2), and Kidney - Cortex (x4.0).
This gene is overexpressed in Adipocyte (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HOXD11 Gene
NURSA nuclear receptor signaling pathways regulating expression of HOXD11 Gene:
HOXD11SOURCE GeneReport for Unigene cluster for HOXD11 Gene:
Hs.421136Evidence on tissue expression from TISSUES for HOXD11 Gene
- Kidney(2.5)
- Stomach(2.5)
- Muscle(2.2)
- Nervous system(2.2)
- Heart(2.1)
Primer Products
-
OriGene qPCR primer pairs for HOXD11
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXD11 Gene
Orthologs for HOXD11 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HOXD11 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HOXD11 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | HOXD 35 |
|
OneToOne | |
| HOXD11 34 |
|
||||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
ManyToMany | |
| mouse (Mus musculus) |
Mammalia | Hoxd11 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HOXD11 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HOXD11 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HOXD11 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hoxd11 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hoxd11a 34 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for HOXD11 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HOXD11 Gene
Paralogs for HOXD11 Gene
(13) SIMAP similar genes for HOXD11 Gene using alignment to 2 proteins:
Variants for HOXD11 Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000374466 | -- | 176,108,138(+) | GCAGG(G/T)AGGCA | upstream-variant-2KB, splice-donor-variant | |
| rs1000419816 | -- | 176,108,730(+) | GCACT(C/T)TCTCC | intron-variant, upstream-variant-2KB | |
| rs1000580695 | -- | 176,109,113(+) | GTCTG(C/G)AGTAT | upstream-variant-2KB, reference, missense | |
| rs1001720766 | -- | 176,109,059(+) | TCAAA(A/C)TCTGG | upstream-variant-2KB, reference, missense | |
| rs1001926822 | -- | 176,108,306(+) | GGTAG(A/C/G)AAACC | intron-variant, upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv676n67 | CNV | gain | 20364138 |
| dgv7173n54 | CNV | loss | 21841781 |
| nsv1072996 | CNV | deletion | 25765185 |
| nsv1112777 | CNV | deletion | 24896259 |
| nsv1126572 | CNV | deletion | 24896259 |
| nsv517968 | CNV | loss | 19592680 |
| nsv520227 | CNV | loss | 19592680 |
| nsv524250 | CNV | loss | 19592680 |
| nsv527187 | CNV | loss | 19592680 |
| nsv583673 | CNV | loss | 21841781 |
Gene Damage Index Score:
1.42;
27.96% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HOXD11 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXD11 Gene
Disorders for HOXD11 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| syndactyly, type v |
|
|
| synpolydactyly |
|
|
| brachydactyly-syndactyly syndrome |
|
|
| syndactyly |
|
|
| renal hypodysplasia/aplasia 1 |
|
|
Search HOXD11 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for HOXD11
No data available for UniProtKB/Swiss-Prot and Genatlas for HOXD11 Gene
Publications for HOXD11 Gene
- Study of HOXD genes in autism particularly regarding the ratio of second to fourth digit length. (PMID: 19540081) Sugie Y. … Osawa J. (Brain Dev. 2010) 3 46 64
- Absence of mutations in the HOXA11 and HOXD11 genes in children with congenital renal malformations. (PMID: 19255789) Bouba I. … Georgiou I. (Pediatr. Nephrol. 2009) 3 46 64
- High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 46 64
- Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot. (PMID: 19938081) Ester A.R. … Hecht J.T. (Am. J. Med. Genet. A 2009) 3 46 64
- Mutations in HOXD13 underlie syndactyly type V and a novel brachydactyly-syndactyly syndrome. (PMID: 17236141) Zhao X. … Zhang X. (Am. J. Hum. Genet. 2007) 3 4 64
Products for HOXD11 Gene
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- ViGene Biosciences adenoviral particle packaged cDNA for HOXD11 gene
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- VectorBuilder custom plasmid, inducible vectors for HOXD11
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HOXD11
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HOXD11 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
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