Aliases for HOXD10 Gene
External Ids for HOXD10 Gene
Previous HGNC Symbols for HOXD10 Gene
Previous GeneCards Identifiers for HOXD10 Gene
This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOXD10 Gene
HOXD10 (Homeobox D10) is a Protein Coding gene. Diseases associated with HOXD10 include vertical talus, congenital and congenital vertical talus, unilateral. Among its related pathways are MicroRNAs in cancer and Proteoglycans in cancer. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is HOXD11.
UniProtKB/Swiss-Prot for HOXD10 Gene
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.