Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HOXD10 Gene

protein-coding   GIFtS: 56
GCID: GC02P176973

homeobox D10

(Previous name: homeo box D10 )
(Previous symbols: HOX4, HOX4D)
 Explore 17 diseases affiliated with
HOXD10 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HOXD10    

Aliases
for HOXD10 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Homeobox D101 2     Homeobox Protein Hox-4E2 3
HOX4D1 2 3 5     HOX4E2 3
HOX41 2     Hox-4.42
Homeo Box D101 2     Homeo Box 4D2
Homeobox Protein Hox-4D2 3     Homeobox Protein Hox-D102

External Ids:    HGNC: 51331   Entrez Gene: 32362   Ensembl: ENSG000001287107   OMIM: 1429845   UniProtKB: P283583   

Export aliases for HOXD10 gene to outside databases

Previous GC identifers: GC02P175034 GC02P175642 GC02P176945 GC02P177184 GC02P176807 GC02P176689 GC02P168858


Summaries
for HOXD10 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HOXD10:
This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is
included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a
sequence-specific transcription factor that is expressed in the developing limb buds and is involved in
differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital
vertical talus (also known as 'rocker-bottom foot' deformity or congenital convex pes valgus) and/or a foot deformity
resembling that seen in Charcot-Marie-Tooth disease. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HXD10_HUMAN, P28358
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXD10


Genomic Views
for HOXD10 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HOXD10 gene promoter:
         E2F-3a   PPAR-gamma1   E2F   E2F-1   E2F-2   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HOXD10 promoter sequence
   Search SABiosciences Chromatin IP Primers for HOXD10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOXD10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

HOXD10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXD10 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P176973:  view genomic region     (about GC identifiers)

Start:
 176,973,518 bp from pter      End:
 176,984,670 bp from pter
Size:
 11,153 bases      Orientation:
 plus strand

Proteins
for HOXD10 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HXD10_HUMAN, P28358 (See protein sequence)
Recommended Name: Homeobox protein Hox-D10  
Size: 340 amino acids; 38411 Da
Subcellular location: Nucleus
Developmental stage: Expressed in the developing limb buds
Secondary accessions: Q6NT10

Explore the universe of human proteins at neXtProt for HOXD10: NX_P28358

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P28358

    • HOXD10 Protein expression data from MOPED and PaxDb:    About this image 
    HOXD10 Protein Expression
    REFSEQ proteins: NP_002139.2  
    ENSEMBL proteins: 
     ENSP00000249501  

    Human Recombinant Protein Products for HOXD10: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: HOXD10
    OriGene Custom Protein Services for HOXD10 
    GenScript Custom Purified and Recombinant Proteins Services for HOXD10
    Novus Biologicals HOXD10 Proteins
    Novus Biologicals HOXD10 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HOXD10

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    HOXD10 for ontologies           About GeneDecksing



    HOXD10 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of HOXD10
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 3): HOXD10
    OriGene Custom Antibody Services for HOXD10 
    GenScript Custom Superior Antibodies Services for HOXD10
    Novus Biologicals HOXD10 Antibodies
    Abcam antibodies for HOXD10 
    Uscn Antibodies for HOXD10
    ThermoFisher Antibodies for HOXD10

    Assay Products for HOXD10: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HOXD10
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for HOXD10

    Protein Domains /
    Families
    for HOXD10 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HOXD10 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR020479 Homeobox_metazoa
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P28358

    ProtoNet protein and cluster: P28358

    UniProtKB/Swiss-Prot: HXD10_HUMAN, P28358
    Similarity: Belongs to the Abd-B homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for HOXD10 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HXD10_HUMAN, P28358
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
    with specific positional identities on the anterior-posterior axis

         Genatlas biochemistry entry for HOXD10:
    homeo box D10(4D),homologous to mouse Hox-4.5

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
    GO:0043565sequence-specific DNA binding IEA--
         
    HOXD10 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for HOXD10:
     Decreased Salmonella enterica   Synthetic lethal with c-Myc af 

         9 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Hoxd10):
     behavior/neurological  cellular  limbs/digits/tail  mortality/aging  muscle 
     nervous system  renal/urinary system  reproductive system  skeleton 

    HOXD10 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Hoxd10tm1Mrc for HOXD10
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HOXD10 

    miRNA
    Products:            		miRTarBase miRNAs that target HOXD10:
    hsa-mir-10b (MIRT002021)

    OriGene 3'-UTR Clone: HOXD10
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXD10
    8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXD10 (see all 27):
    hsa-miR-579 hsa-miR-137 hsa-miR-10b hsa-miR-25 hsa-miR-501-3p hsa-miR-520a-5p hsa-miR-218 hsa-miR-502-3p
    SwitchGear 3'UTR luciferase reporter plasmid: HOXD10 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXD10 (see all 7)
    OriGene shRNA RFP: HOXD10
    OriGene siRNA: HOXD10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXD10
    Sirion Biotech Custom design and validation of potent shRNA sequences against HOXD10 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HOXD10
    Sirion Biotech Customized adenovirus for overexpression of HOXD10 
    Sirion Biotech Customized adenovirus for potent knockdown of HOXD10

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HOXD10 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HOXD10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HOXD10 (NM_002148)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXD10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXD10 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for HOXD10
    Search LifeMap BioReagents cell lines for HOXD10
    Sirion Biotech Customized stable knockdown cell line services for HOXD10 
    Sirion Biotech Customized inducible knockdown cell line services for HOXD10
    Sirion Biotech Customized stable overexpressing cell line services for HOXD10
    Sirion Biotech Customized inducible overexpressing cell line services for HOXD10

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXD10


    Pathways & Interactions
    for HOXD10 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HOXD10

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/9 Interacting proteins for HOXD10 (P283583 ENSP000002495014) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GMNNO754963, ENSP000002300564I2D: score=4 STRING: ENSP00000230056
    PBX1P404243, ENSP000004058904I2D: score=2 STRING: ENSP00000405890
    HMGB1P094293, ENSP000003430404I2D: score=1 STRING: ENSP00000343040
    CREBBPQ927933, ENSP000002623674I2D: score=3 STRING: ENSP00000262367
    EP300Q094723, ENSP000002632534I2D: score=1 STRING: ENSP00000263253
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development ----
    GO:0006351transcription, DNA-dependent IEA--
    GO:0007519skeletal muscle tissue development IEA--
    GO:0008344adult locomotory behavior IEA--
    GO:0009952anterior/posterior pattern specification IEA--

    HOXD10 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HOXD10 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HOXD10
    Search CenterWatch for drugs/clinical trials and news about HOXD10 / HXD10 

    Transcripts
    for HOXD10 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HOXD10 gene: 
    NM_002148.3  

    Unigene Cluster for HOXD10:

    Homeobox D10
    Hs.123070  [show with all ESTs]
    Unigene Representative Sequence: NM_002148
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000490088 ENST00000549469 ENST00000249501(uc002ukj.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: HOXD10
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXD10
    8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXD10 (see all 27):
    hsa-miR-579 hsa-miR-137 hsa-miR-10b hsa-miR-25 hsa-miR-501-3p hsa-miR-520a-5p hsa-miR-218 hsa-miR-502-3p
    SwitchGear 3'UTR luciferase reporter plasmid: HOXD10 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXD10 (see all 7)
    OriGene shRNA RFP: HOXD10
    OriGene siRNA: HOXD10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXD10
    Sirion Biotech Custom design and validation of potent shRNA sequences against HOXD10 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HOXD10 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HOXD10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HOXD10 (NM_002148)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXD10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXD10 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HOXD10
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HOXD10
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXD10
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXD10

    Additional cDNA sequence: 

    AK309451.1 BC069619.1 BC074760.2 X59373.1 

    3 DOTS entries:

    DT.304840  DT.427951  DT.91699612 

    24/56 AceView cDNA sequences (see all 56):

    NM_021192 BC074760 AI139039 NM_002148 BC069619 AW206798 AA653427 AW205221 
    BF510955 AI095929 BF939744 AW630600 BM903736 BP380736 AI277208 AW195017 
    BF526767 AW243295 BX114645 BX117343 CD614162 CB151522 AA479366 CA431276 

    GeneLoc Exon Structure


    Expression
    for HOXD10 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HOXD10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATAATGCAA
    HOXD10 Expression
    About this image

    HOXD10 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    9 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbLimb BudLimb Bud Mesenchyme CellsMesoderm
    LimbLimb BudProgress Zone CellsBone, Cartilage
    LimbLimb BudZone Of Polarizing Activity CellsMesoderm
    LimbStylopodPrechondrocytic Mesenchymal CellsBone, Cartilage
    SomiteSacral Mesencymal SclerotomeSacral Sclerotome CellsBone, Cartilage, Tendons & Ligaments
    Spinal CordLumbar Lateral Motor ColumnLateral Motor NeuronsMotor Neurons
    KidneyMetanephric MesenchymeMetanephric Mesenchyme CellsKidney
    Neural TubeNeural TubeSpinal Neural Tube CellsNeural Ectoderm
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Trophoblast-like cells (Generation of tropho...)

    See HOXD10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HOXD10

    SOURCE GeneReport for Unigene cluster: Hs.123070

    UniProtKB/Swiss-Prot: HXD10_HUMAN, P28358
    Tissue specificity: Strongly expressed in the adult male and female urogenital tracts

        SABiosciences Expression via Pathway-Focused PCR Arrays including HOXD10: 
              Stem Cell Transcription Factors in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HOXD10
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HOXD10
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXD10
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXD10
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXD10

    Orthologs
    for HOXD10 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for HOXD10 gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves HOXD101 homeobox D10 87.08(n)
    92.31(a)    		   771246  XM_001234538.2  XP_001234539.2 
    lizard
    (Anolis carolinensis)    		 Reptilia HOXD106
    HOXD96
    		 --
    		 97(a)
    18(a)
    		 1 ↔ 1
    possible ortholog
    		 GL343356.1(541598-541882)
    GL343356.1(518262-536480)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC686112 homeo box D10 82.61(n)    BC061944.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii hoxd10a2 homeo box D10a 77.1(n)   30404  NM_131166.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea nob-16
    		 kNOB-like posterior (NO Backside) family member (n...
    		 18(a)
    		 1 → many
    		 III(12077688-12084220)


    ENSEMBL Gene Tree for HOXD10 (if available)
    TreeFam Gene Tree for HOXD10 (if available) 

    Paralogs
    for HOXD10 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HOXD10 gene
    HOXA92  HOXA132  HOXC92  HOXD112  HOXC122  ENSG000002571842  HOXB132  HOXC112  
    HOXA112  HOXD132  HOXC132  HOXB92  HOXC102  HOXD92  HOXD122  HOXA102  
    2 SIMAP similar genes for HOXD10 using alignment to 1 protein entry:     HXD10_HUMAN:
    HOXC10    HOXA10

    HOXD10 for paralogs           About GeneDecksing



    Genomic Variants
    for HOXD10 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/129 NCBI SNPs in HOXD10 are shown (see all 129)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1048936341,2
    		Cpathogenic176983892(+) CCGAAA/TGAAAC 2 K M mis10--------
    rs1905356681,2
    		--176979493(+) AAATGA/TTCTAT 1 -- us2k10--------
    rs1823698601,2
    		--176979658(+) CTTGGC/GTGGCA 1 -- us2k10--------
    rs1837998021,2
    		--176979693(+) GACGGC/TTCCAA 1 -- us2k10--------
    rs1461953961,2
    		C--176979860(+) TTCCA-/TGG   
      TGGTAG    TGGTG     		1 -- us2k10--------
    rs786469741,2
    		--176979959(+) TCCCTC/TACCAA 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1421295421,2
    		--176980037(+) TTTCAA/GAAATT 1 -- us2k10--------
    rs1166135151,2
    		F--176980062(+) AACTCA/CACTTC 1 -- us2k11Minor allele frequency- C:0.05WA 118
    rs755891841,2
    		--176980127(+) TTCTTG/CGTTAG 1 -- us2k12Minor allele frequency- C:0.04CSA WA 119
    rs116850801,2
    		C,H--176980253(+) AAAGTA/GTCTTC 1 -- us2k11Minor allele frequency- G:0.00NA 2

    HapMap Linkage Disequilibrium report for HOXD10 (176973518 - 176984670 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HOXD10: --
    Human Gene Mutation Database (HGMD): HOXD10

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HOXD10
    DNA2.0 Custom Variant and Variant Library Synthesis for HOXD10

    Disorders / Diseases
    for HOXD10 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HOXD10 for disorders           About GeneDecksing

    OMIM gene information: 142984   
    OMIM disorders: 192950  
    UniProtKB/Swiss-Prot: HXD10_HUMAN, P28358
  • Defects in HOXD10 are a cause of congenital vertical talus (CVT) [MIM:192950]; also known as rocker-bottom
    • foot deformity or congenital convex pes valgus. CVT is a dislocation of the talonavicular joint, with rigid dorsal
    dislocation of the navicular over the neck of the talus. This condition is usually associated with multiple other
    congenital deformities and only rarely is an isolated deformity

    17 diseases for HOXD10:    About MalaCards
    charcot-marie-tooth disease    vertical talus    charcot-marie-tooth disease, foot deformity of    tooth disease
    vertical talus, congenital    wilms tumor    brachydactyly-syndactyly syndrome    talipes equinovarus
    syndactyly    synpolydactyly    brachydactyly    clubfoot
    endometrial adenocarcinoma    adenocarcinoma    neuroblastoma    thyroiditis
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for HOXD10:
    Clubfoot

    2 Novoseek disease relationships for HOXD10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vertical talus, congenital 94.9 1 15368082 (1)
    charcot-marie-tooth disease 76 1 16450407 (1)

    Human Genome Epidemiology (HuGE) Navigator: HOXD10 (4 documents)

    Export disorders for HOXD10 gene to outside databases

    Publications
    for HOXD10 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HOXD10 gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with HOXD10)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. HOX4 genes encode transcription factors with potential auto- and cross-regulatory capacities. (PubMed id 1756725)1, 2, 9 Zappavigna V.... Duboule D. (1991)
    2. A HOX gene mutation in a family with isolated congenital vertical talus and Charcot-Marie-Tooth disease. (PubMed id 15146389)1, 2, 9 Shrimpton A.E.... Hootnick D.R. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (1992)
    5. Human HOX4E: a gene strongly expressed in the adult male and female urogenital tracts. (PubMed id 1351871)1, 2 Redline R.W.... Collins T. (1992)
    6. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (1990)
    7. The human HOX gene family. (PubMed id 2574852)1, 2 Acampora D.... Boncinelli E. (1989)
    8. MicroRNA-7, a homeobox D10 target, inhibits p21-activated kinase 1 and regulates its functions. (PubMed id 18922890)1, 9 Reddy S.D....Kumar R. (2008)
    9. Congenital vertical talus in four generations of the same family. (PubMed id 15368082)1, 9 Levinsohn E.M....Hootnick D.R. (2004)
    10. Homeobox D10 gene, a candidate tumor suppressor, is do wnregulated through promoter hypermethylation and associated with gastric carcin ogenesis. (PubMed id 22160393)1 Wang L....Si J. (2012)

    External Searches for HOXD10 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HOXD10 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3236 HGNC: 5133 AceView: HOXD10andHOXD11 Ensembl:ENSG00000128710 euGenes: HUgn3236
    ECgene: HOXD10 H-InvDB: HOXD10

    Other Databases showing HOXD10 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HOXD10 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HOXD10 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/HOXD10

    Intellectual Property
    for HOXD10 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HOXD10 gene:
    Search GeneIP for patents involving HOXD10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for HOXD10 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of HOXD10
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for HOXD10   OriGene shRNA RFP for HOXD10  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXD10   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HOXD10  
     OriGene Protein Over-expression Lysate for HOXD10   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for HOXD10   OriGene 3'-UTR Clone for HOXD10  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HOXD10   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HOXD10  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HOXD10   OriGene Custom Protein Services for HOXD10  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HOXD10
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HOXD10
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOXD10
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXD10
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXD10
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXD10
     GenScript Custom Purified and Recombinant Proteins Services for HOXD10 GenScript cDNA clones with any tag delivered in your preferred vector for HOXD10
     GenScript Custom Assay Services for HOXD10 GenScript Custom Superior Antibodies Services for HOXD10
     GenScript Custom overexpressing Cell Line Services for HOXD10 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HOXD10 promoter
     Search Chromatin IP Primers for HOXD10
     RT2 qPCR Primer Assay in human, mouse, rat HOXD10
     Search GNC Networks for HOXD10
     SABiosciences PCR Arrays including human, mouse, rat HOXD10
     Search Tocris compounds for HOXD10
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     HOXD10 antibodies
     HOXD10 proteins
     HOXD10 lysates
     Antibodies for HOXD10
     See all of Abcam's Antibodies, Kits and Proteins for HOXD10
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     HOXD10 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for HOXD10
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXD10
     SwitchGear 3'UTR luciferase reporter plasmids for HOXD10
     SwitchGear Promoter luciferase reporter plasmids for HOXD10
     ThermoFisher Antibodies for HOXD10
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXD10
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HOXD10
    Sirion Biotech Customized:
     stable knockdown cell line services for HOXD10
     inducible knockdown cell line services for HOXD10
     design and validation of potent shRNA sequences against HOXD10
     adenovirus for potent knockdown of HOXD10
     adenovirus for overexpression of HOXD10
     stable overexpressing cell line services for HOXD10
     inducible overexpressing cell line services for HOXD10
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      HOXD10 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4