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HOXD10 Gene

protein-coding   GIFtS: 60
GCID: GC02P176973

Homeobox D10

(Previous name: homeo box D10)
(Previous symbols: HOX4, HOX4D)
  See HOXD10-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Homeobox D101 2     Homeobox Protein Hox-4E2 3
HOX4D1 2 3 5     HOX4E2 3
HOX41 2     Hox-4.42
Homeo Box D101 2     Homeo Box 4D2
Homeobox Protein Hox-4D2 3     Homeobox Protein Hox-D102

External Ids:    HGNC: 51331   Entrez Gene: 32362   Ensembl: ENSG000001287107   OMIM: 1429845   UniProtKB: P283583   

Export aliases for HOXD10 gene to outside databases

Previous GC identifers: GC02P175034 GC02P175642 GC02P176945 GC02P177184 GC02P176807 GC02P176689 GC02P168858


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HOXD10 Gene:
This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is
included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a
sequence-specific transcription factor that is expressed in the developing limb buds and is involved in
differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and
congenital vertical talus (also known as 'rocker-bottom foot' deformity or congenital convex pes valgus) and/or a
foot deformity resembling that seen in Charcot-Marie-Tooth disease. (provided by RefSeq, Jul 2008)

GeneCards Summary for HOXD10 Gene:
HOXD10 (homeobox D10) is a protein-coding gene. Diseases associated with HOXD10 include congenital vertical talus, bilateral, and charcot-marie-tooth disease, foot deformity of. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is HOXD11.

UniProtKB/Swiss-Prot: HXD10_HUMAN, P28358
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXD10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the HOXD10 gene promoter:
         E2F-3a   PPAR-gamma1   E2F   E2F-1   E2F-2   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHOXD10 promoter sequence
   Search Chromatin IP Primers for HOXD10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HOXD10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

HOXD10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXD10 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P176973:  view genomic region     (about GC identifiers)

Start:
176,973,518 bp from pter      End:
176,984,670 bp from pter
Size:
11,153 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HXD10_HUMAN, P28358 (See protein sequence)
Recommended Name: Homeobox protein Hox-D10  
Size: 340 amino acids; 38411 Da
Developmental stage: Expressed in the developing limb buds
Secondary accessions: Q6NT10

Explore the universe of human proteins at neXtProt for HOXD10: NX_P28358

Explore proteomics data for HOXD10 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HOXD10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002139.2  
    ENSEMBL proteins: 
     ENSP00000249501  

    HOXD10 Human Recombinant Protein Products:

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    antibodies-online proteins for HOXD10 (10 products) 

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HOXL: Homeoboxes / ANTP class : HOXL subclass

    4 InterPro protein domains:
     IPR020479 Homeobox_metazoa
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P28358

    ProtoNet protein and cluster: P28358

    UniProtKB/Swiss-Prot: HXD10_HUMAN, P28358
    Similarity: Belongs to the Abd-B homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Find genes that share domains with HOXD10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HXD10_HUMAN, P28358
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
    cells with specific positional identities on the anterior-posterior axis

         Genatlas biochemistry entry for HOXD10:
    homeo box D10(4D),homologous to mouse Hox-4.5

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with HOXD10           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for HOXD10:
     Decreased Salmonella enterica   Synthetic lethal with c-Myc af 

         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Hoxd10):
     behavior/neurological  cellular  limbs/digits/tail  mortality/aging  muscle 
     nervous system  renal/urinary system  reproductive system  skeleton 

    Find genes that share phenotypes with HOXD10           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Hoxd10tm1Mrc for HOXD10

       genOway: Develop your customized and physiologically relevant rodent model for HOXD10

    miRNA
    Products:
        
    miRTarBase miRNAs that target HOXD10:
    hsa-mir-339-5p (MIRT042798), hsa-mir-10b-5p (MIRT002021)

    Block miRNA regulation of human, mouse, rat HOXD10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HOXD10 (see all 27):
    hsa-miR-579 hsa-miR-137 hsa-miR-10b hsa-miR-25 hsa-miR-501-3p hsa-miR-520a-5p hsa-miR-218 hsa-miR-502-3p
    SwitchGear 3'UTR luciferase reporter plasmidHOXD10 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HOXD10

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    Sino Biological Human cDNA Clone for HOXD10
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXD10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXD10
    Addgene plasmids for HOXD10 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXD10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HXD10_HUMAN, P28358: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with HOXD10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HOXD10 About    
    See pathways by source

    SuperPathContained pathways About
    1Proteoglycans in cancer
    Proteoglycans in cancer
    2MicroRNAs in cancer
    MicroRNAs in cancer


    Find genes that share SuperPaths with HOXD10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    2 Kegg Pathways  (Kegg details for HOXD10):
        Proteoglycans in cancer
    MicroRNAs in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HOXD10: 
              Stem Cell Transcription Factors in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for HOXD10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for HOXD10 (P283583 ENSP000002495014) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000225987P404253, ENSP000004039484I2D: score=1 STRING: ENSP00000403948
    ENSG00000232005P404253, ENSP000003900094I2D: score=1 STRING: ENSP00000390009
    ENSG00000236353P404253, ENSP000004107104I2D: score=1 STRING: ENSP00000410710
    ENSG00000237344P404253, ENSP000003971774I2D: score=1 STRING: ENSP00000397177
    PBX2P404253, ENSP000003641904I2D: score=1 STRING: ENSP00000364190
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development ----
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007519skeletal muscle tissue development IEA--
    GO:0008344adult locomotory behavior IEA--

    Find genes that share ontologies with HOXD10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HOXD10 (HXD10)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HOXD10 gene: 
    NM_002148.3  

    Unigene Cluster for HOXD10:

    Homeobox D10
    Hs.123070  [show with all ESTs]
    Unigene Representative Sequence: NM_002148
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000490088 ENST00000549469 ENST00000249501(uc002ukj.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HOXD10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HOXD10 (see all 27):
    hsa-miR-579 hsa-miR-137 hsa-miR-10b hsa-miR-25 hsa-miR-501-3p hsa-miR-520a-5p hsa-miR-218 hsa-miR-502-3p
    SwitchGear 3'UTR luciferase reporter plasmidHOXD10 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HOXD10
      QuantiTect SYBR Green Assays in human, mouse, rat HOXD10
      QuantiFast Probe-based Assays in human, mouse, rat HOXD10

    Additional mRNA sequence: 

    AK309451.1 BC069619.1 BC074760.2 X59373.1 

    3 DOTS entries:

    DT.304840  DT.427951  DT.91699612 

    Selected AceView cDNA sequences (see all 56):

    NM_021192 AW206798 BF510955 BC074760 BC069619 AI095929 AA653427 AI139039 
    NM_002148 AW205221 BP380736 AA479366 AL526269 CA431276 BX114645 BF680250 
    AI423516 X59373 AA256875 BX117343 CD614162 BF526767 BF939744 BM903736 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HOXD10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATAATGCAA
    HOXD10 Expression
    About this image


    HOXD10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Progress Zone Cells Limb Bud
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Progress Zone Cells Limb Bud
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Progress Zone Cells Limb Bud
     
     Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Limb Bud Mesenchyme Cells Limb Bud
     
     Somite (Muscoskeletal System)
             Sacral Sclerotome Cells Sacral Mesenchymal Sclerotome
    HOXD10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HOXD10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.123070

    UniProtKB/Swiss-Prot: HXD10_HUMAN, P28358
    Tissue specificity: Strongly expressed in the adult male and female urogenital tracts

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HOXD10: 
              Stem Cell Transcription Factors in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXD10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HOXD10 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hoxd101 , 5 homeobox D101, 5 97.16(n)1
    98.82(a)1
      2 (44.13 cM)5
    154301  NM_013554.51  NP_038582.21 
     746910905 
    chicken
    (Gallus gallus)
    Aves HOXD101 homeobox D10 87.08(n)
    92.31(a)
      771246  XM_001234538.3  XP_001234539.2 
    lizard
    (Anolis carolinensis)
    Reptilia HOXD106
    homeobox D10
    80(a)
    1 ↔ 1
    GL343356.1(540758-544447)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC686112 homeo box D10 82.61(n)    BC061944.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hoxd10a2 homeo box D10a 77.1(n)   30404  NM_131166.1 


    ENSEMBL Gene Tree for HOXD10 (if available)
    TreeFam Gene Tree for HOXD10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HOXD10 gene
    HOXD112  ENSG000002571842  HOXC132  HOXC102  HOXD122  HOXA92  HOXA132  HOXC92  
    HOXB132  HOXC122  HOXC112  HOXD132  HOXA112  HOXB92  HOXD92  HOXA102  
    2 SIMAP similar genes for HOXD10 using alignment to 1 protein entry:     HXD10_HUMAN:
    HOXC10    HOXA10

    Find genes that share paralogs with HOXD10           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HOXD10 (see all 168)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0225824
    Vertical talus, congenital (CVT)4--see VAR_0225822 M K mis40--------
    rs1048936341,2
    Cpathogenic1176378761(+) CCGAAA/TGAAAC 2 K M mis10--------
    rs1905356681,2
    --176374362(+) AAATGA/TTCTAT 1 -- us2k10--------
    rs1823698601,2
    --176374527(+) CTTGGC/GTGGCA 1 -- us2k10--------
    rs1837998021,2
    C--176374562(+) GACGGC/TTCCAA 1 -- us2k10--------
    rs1461953961,2
    C--176374729(+) TTCCA-/TGG   
      TGGTAG
    TGGTG
    1 -- us2k10--------
    rs786469741,2
    F--176374828(+) TCCCTC/TACCAA 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1421295421,2
    --176374906(+) TTTCAA/GAAATT 1 -- us2k10--------
    rs1166135151,2
    F--176374931(+) AACTCA/CACTTC 1 -- us2k11Minor allele frequency- C:0.05WA 118
    rs755891841,2
    F--176374996(+) TTCTTG/CGTTAG 1 -- us2k12Minor allele frequency- C:0.04CSA WA 119

    HapMap Linkage Disequilibrium report for HOXD10 (176973518 - 176984670 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for HOXD10:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv875442CNV Loss21882294
    dgv4368n71CNV Loss21882294
    nsv875438CNV Loss21882294
    nsv875437CNV Loss21882294
    nsv875446CNV Loss21882294
    nsv527187CNV Loss19592680
    nsv517968CNV Loss19592680
    dgv676n67CNV Gain20364138

    Human Gene Mutation Database (HGMD): HOXD10
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HOXD10
    DNA2.0 Custom Variant and Variant Library Synthesis for HOXD10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142984   
    OMIM disorders: 192950  
    UniProtKB/Swiss-Prot: HXD10_HUMAN, P28358
  • Vertical talus, congenital (CVT) [MIM:192950]: A rare malformation characterized by vertical orientation
    of the talus with a rigid dorsal dislocation of the navicular, equinus deformity of the calcaneus, abduction
    deformity of the forefoot, and contracture of the soft tissues of the hind- and mid-foot. This condition is
    usually associated with multiple other congenital deformities and only rarely is an isolated deformity with
    familial occurrence. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 9 diseases for HOXD10:    
    About MalaCards
    congenital vertical talus, bilateral    charcot-marie-tooth disease, foot deformity of    congenital vertical talus, unilateral    vertical talus, congenital
    talipes equinovarus    endometrial adenocarcinoma    brachydactyly-syndactyly syndrome    wilms tumor
    charcot-marie-tooth disease

    1 disease from the University of Copenhagen DISEASES database for HOXD10:
    Clubfoot

    Find genes that share disorders with HOXD10           About GenesLikeMe

    2 Novoseek inferred disease relationships for HOXD10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vertical talus, congenital 94.9 1 15368082 (1)
    charcot-marie-tooth disease 76 1 16450407 (1)

    Genetic Association Database (GAD): HOXD10
    Human Genome Epidemiology (HuGE) Navigator: HOXD10 (4 documents)

    Export disorders for HOXD10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HOXD10 gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with HOXD10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. HOX4 genes encode transcription factors with potential auto- and cross-regulatory capacities. (PubMed id 1756725)1, 2, 9 Zappavigna V.... Duboule D. (EMBO J. 1991)
    2. A HOX gene mutation in a family with isolated congenital vertical talus and Charcot-Marie-Tooth disease. (PubMed id 15146389)1, 2, 9 Shrimpton A.E.... Hootnick D.R. (Am. J. Hum. Genet. 2004)
    3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    4. Absence of HOXD10 mutations in idiopathic clubfoot and sporadic vertical talus. (PubMed id 17417092)1, 4 Gurnett C.A....Dobbs M.B. (Clin. Orthop. Relat. Res. 2007)
    5. [Analysis of association between 5' HOXD gene and idiopathic congenital talipes equinovarus]. (PubMed id 16331564)1, 4 Wang L.L....Sun K.L. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (Cell 1992)
    8. Human HOX4E: a gene strongly expressed in the adult male and female urogenital tracts. (PubMed id 1351871)1, 2 Redline R.W.... Collins T. (Genomics 1992)
    9. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (Genomics 1990)
    10. The human HOX gene family. (PubMed id 2574852)1, 2 Acampora D.... Boncinelli E. (Nucleic Acids Res. 1989)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3236 HGNC: 5133 AceView: HOXD10andHOXD11 Ensembl:ENSG00000128710 euGenes: HUgn3236
    ECgene: HOXD10 Kegg: 3236 H-InvDB: HOXD10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HOXD10 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/gtr/tests/252938/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HOXD10 gene:
    Search GeneIP for patents involving HOXD10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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