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Aliases for HOXD10 Gene

Aliases for HOXD10 Gene

  • Homeobox D10 2 3 5
  • Homeobox Protein Hox-4D 3 4
  • Homeobox Protein Hox-4E 3 4
  • Homeo Box D10 2 3
  • HOX4D 3 4
  • HOX4E 3 4
  • Homeobox Protein Hox-D10 3
  • Homeo Box 4D 3
  • Hox-4.4 3
  • HOX4 3

External Ids for HOXD10 Gene

Previous HGNC Symbols for HOXD10 Gene

  • HOX4
  • HOX4D

Previous GeneCards Identifiers for HOXD10 Gene

  • GC02P175034
  • GC02P175642
  • GC02P176945
  • GC02P177184
  • GC02P176807
  • GC02P176689
  • GC02P168858
  • GC02P176973

Summaries for HOXD10 Gene

Entrez Gene Summary for HOXD10 Gene

  • This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXD10 Gene

HOXD10 (Homeobox D10) is a Protein Coding gene. Diseases associated with HOXD10 include Vertical Talus, Congenital and Congenital Vertical Talus, Unilateral. Among its related pathways are Proteoglycans in cancer and MicroRNAs in cancer. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is HOXA10.

UniProtKB/Swiss-Prot for HOXD10 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Wiki entry for HOXD10 Gene

Additional gene information for HOXD10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXD10 Gene

Genomics for HOXD10 Gene

Regulatory Elements for HOXD10 Gene

Enhancers for HOXD10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H176455 1 Ensembl ENCODE 10 +347.1 347100 1 CTCF RB1 BMI1 ZSCAN9 RAD21 ZFHX2 POLR2A SMC3 ZNF143 RCOR1 HOXD4 MIR10B HOXD3 HOXD10 HOXD11 ENSG00000229434 PPIAP67
GH02H176177 1 Ensembl ENCODE 9.7 +69.6 69628 2 CTCF ZNF777 SUZ12 JUN MAX E2F1 ZFHX2 CTBP1 EGR2 EZH2 HAGLROS HAGLR HOXD1 HOXD4 HOXD3 HOXD-AS2 MIR10B HOXD11 HOXD12 HOXD10
GH02H176173 0.8 ENCODE 11 +64.1 64138 0 SOX13 FOXA2 SAP130 SUZ12 RARA CREM HOMEZ EZH2 SOX5 GATAD2A HOXD-AS2 HOXD3 HOXD10 HOXD11 HOXD8 HOXD12 HOXD9 HOXD13 HAGLROS ENSG00000272729
GH02H176159 0.6 ENCODE 11.4 +52.4 52424 3 ELF3 SUZ12 CTBP2 USF2 PRDM4 EZH2 HAGLROS HAGLR HOXD1 HOXD-AS2 HOXD9 HOXD3 HOXD8 HOXD10 HOXD11 HOXD13
GH02H176105 1.1 FANTOM5 5.8 -3.4 -3440 0 INSM2 ZNF76 KLF17 FEZF1 ZEB1 GLIS2 ZNF366 KLF7 EGR2 SP3 HOXD11 HOXD13 HOXD10 HOXD9 HOXD8 HOXD3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HOXD10 on UCSC Golden Path with GeneCards custom track

Genomic Location for HOXD10 Gene

Chromosome:
2
Start:
176,108,790 bp from pter
End:
176,119,942 bp from pter
Size:
11,153 bases
Orientation:
Plus strand

Genomic View for HOXD10 Gene

Genes around HOXD10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOXD10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOXD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXD10 Gene

Proteins for HOXD10 Gene

  • Protein details for HOXD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28358-HXD10_HUMAN
    Recommended name:
    Homeobox protein Hox-D10
    Protein Accession:
    P28358
    Secondary Accessions:
    • Q6NT10

    Protein attributes for HOXD10 Gene

    Size:
    340 amino acids
    Molecular mass:
    38411 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXD10 Gene

Post-translational modifications for HOXD10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXD10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOXD10 Gene

Domains & Families for HOXD10 Gene

Gene Families for HOXD10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for HOXD10 Gene

Suggested Antigen Peptide Sequences for HOXD10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P28358

UniProtKB/Swiss-Prot:

HXD10_HUMAN :
  • Belongs to the Abd-B homeobox family.
Family:
  • Belongs to the Abd-B homeobox family.
genes like me logo Genes that share domains with HOXD10: view

Function for HOXD10 Gene

Molecular function for HOXD10 Gene

GENATLAS Biochemistry:
homeo box D10(4D),homologous to mouse Hox-4.5
UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Phenotypes From GWAS Catalog for HOXD10 Gene

Gene Ontology (GO) - Molecular Function for HOXD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IEA --
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HOXD10: view
genes like me logo Genes that share phenotypes with HOXD10: view

Human Phenotype Ontology for HOXD10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for HOXD10 Gene

MGI Knock Outs for HOXD10:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HOXD10
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for HOXD10 Gene

Localization for HOXD10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXD10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HOXD10 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytoplasmic bodies (2)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HOXD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
GO:0036464 cytoplasmic ribonucleoprotein granule IDA --
genes like me logo Genes that share ontologies with HOXD10: view

Pathways & Interactions for HOXD10 Gene

genes like me logo Genes that share pathways with HOXD10: view

Pathways by source for HOXD10 Gene

2 KEGG pathways for HOXD10 Gene

SIGNOR curated interactions for HOXD10 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for HOXD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with HOXD10: view

Drugs & Compounds for HOXD10 Gene

No Compound Related Data Available

Transcripts for HOXD10 Gene

mRNA/cDNA for HOXD10 Gene

Unigene Clusters for HOXD10 Gene

Homeobox D10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HOXD10
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for HOXD10 Gene

No ASD Table

Relevant External Links for HOXD10 Gene

GeneLoc Exon Structure for
HOXD10
ECgene alternative splicing isoforms for
HOXD10

Expression for HOXD10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HOXD10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXD10 Gene

This gene is overexpressed in Uterus (x13.3), Vagina (x7.8), Colon - Sigmoid (x6.9), Cervix - Ectocervix (x5.5), Kidney - Cortex (x4.9), and Prostate (x4.8).

NURSA nuclear receptor signaling pathways regulating expression of HOXD10 Gene:

HOXD10

SOURCE GeneReport for Unigene cluster for HOXD10 Gene:

Hs.123070

mRNA Expression by UniProt/SwissProt for HOXD10 Gene:

P28358-HXD10_HUMAN
Tissue specificity: Strongly expressed in the adult male and female urogenital tracts.

Evidence on tissue expression from TISSUES for HOXD10 Gene

  • Intestine(4.2)
  • Nervous system(4.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXD10 Gene

Germ Layers:
  • mesoderm
Systems:
  • skeletal muscle
  • skeleton
Organs:
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
genes like me logo Genes that share expression patterns with HOXD10: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for HOXD10 Gene

Orthologs for HOXD10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HOXD10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOXD10 33 34
  • 99.8 (n)
dog
(Canis familiaris)
Mammalia HOXD11 33
  • 98.24 (n)
HOXD10 34
  • 83 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HOXD10 33 34
  • 97.45 (n)
rat
(Rattus norvegicus)
Mammalia Hoxd10 33
  • 97.45 (n)
mouse
(Mus musculus)
Mammalia Hoxd10 33 16 34
  • 97.16 (n)
oppossum
(Monodelphis domestica)
Mammalia HOXD10 34
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves HOXD10 33 34
  • 87.08 (n)
lizard
(Anolis carolinensis)
Reptilia HOXD10 34
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxd10 33
  • 83.04 (n)
Str.2493 33
African clawed frog
(Xenopus laevis)
Amphibia MGC68611 33
zebrafish
(Danio rerio)
Actinopterygii hoxd10a 33 34
  • 70.9 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 22 (a)
OneToMany
Species where no ortholog for HOXD10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXD10 Gene

ENSEMBL:
Gene Tree for HOXD10 (if available)
TreeFam:
Gene Tree for HOXD10 (if available)

Paralogs for HOXD10 Gene

(2) SIMAP similar genes for HOXD10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HOXD10: view

Variants for HOXD10 Gene

Sequence variations from dbSNP and Humsavar for HOXD10 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs104893634 Pathogenic, Vertical talus, congenital (CVT) [MIM:192950] 176,119,164(+) CCGAA(A/T)GAAAC reference, missense
rs114746583 Likely benign 176,119,278(+) GAGGG(G/T)GCACC utr-variant-3-prime
rs116807022 Likely benign 176,119,233(+) TTAGG(C/T)CTGAG utr-variant-3-prime
rs144160937 Likely benign 176,119,206(+) AGAAC(C/T)GACCG reference, missense
rs149038150 Likely benign 176,117,205(+) CTCAT(G/T)TCGGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for HOXD10 Gene

Variant ID Type Subtype PubMed ID
dgv676n67 CNV gain 20364138
dgv7173n54 CNV loss 21841781
nsv517968 CNV loss 19592680
nsv527187 CNV loss 19592680
nsv583673 CNV loss 21841781

Variation tolerance for HOXD10 Gene

Residual Variation Intolerance Score: 42.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HOXD10 Gene

Human Gene Mutation Database (HGMD)
HOXD10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HOXD10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXD10 Gene

Disorders for HOXD10 Gene

MalaCards: The human disease database

(9) MalaCards diseases for HOXD10 Gene - From: HGMD, OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
vertical talus, congenital
  • charcot-marie-tooth disease, foot deformity of
congenital vertical talus, unilateral
congenital vertical talus, bilateral
synpolydactyly
  • synpolydactyly 1
syndactyly, type v
  • syndactyly type 5
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

HXD10_HUMAN
  • Vertical talus, congenital (CVT) [MIM:192950]: A rare malformation characterized by vertical orientation of the talus with a rigid dorsal dislocation of the navicular, equinus deformity of the calcaneus, abduction deformity of the forefoot, and contracture of the soft tissues of the hind- and mid-foot. This condition is usually associated with multiple other congenital deformities and only rarely is an isolated deformity with familial occurrence. {ECO:0000269 PubMed:15146389}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for HOXD10

Genetic Association Database (GAD)
HOXD10
Human Genome Epidemiology (HuGE) Navigator
HOXD10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HOXD10
genes like me logo Genes that share disorders with HOXD10: view

No data available for Genatlas for HOXD10 Gene

Publications for HOXD10 Gene

  1. A HOX gene mutation in a family with isolated congenital vertical talus and Charcot-Marie-Tooth disease. (PMID: 15146389) Shrimpton AE … Hootnick DR (American journal of human genetics 2004) 3 4 22 60
  2. HOX4 genes encode transcription factors with potential auto- and cross-regulatory capacities. (PMID: 1756725) Zappavigna V … Duboule D (The EMBO journal 1991) 3 4 22 60
  3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges LM … MrOS Research Group (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009) 3 45 60
  4. MicroRNA-7, a homeobox D10 target, inhibits p21-activated kinase 1 and regulates its functions. (PMID: 18922890) Reddy SD … Kumar R (Cancer research 2008) 3 22 60
  5. Absence of HOXD10 mutations in idiopathic clubfoot and sporadic vertical talus. (PMID: 17417092) Gurnett CA … Dobbs MB (Clinical orthopaedics and related research 2007) 3 45 60

Products for HOXD10 Gene

Sources for HOXD10 Gene

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