Aliases for HOXD10 Gene
Aliases for HOXD10 Gene
External Ids for HOXD10 Gene
- HGNC: 5133
- Entrez Gene: 3236
- Ensembl: ENSG00000128710
- OMIM: 142984
- UniProtKB: P28358
Previous HGNC Symbols for HOXD10 Gene
- HOX4
- HOX4D
Previous GeneCards Identifiers for HOXD10 Gene
- GC02P175034
- GC02P175642
- GC02P176945
- GC02P177184
- GC02P176807
- GC02P176689
- GC02P168858
- GC02P176973
Summaries for HOXD10 Gene
-
This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOXD10 Gene
HOXD10 (Homeobox D10) is a Protein Coding gene. Diseases associated with HOXD10 include Vertical Talus, Congenital and Congenital Vertical Talus, Unilateral. Among its related pathways are MicroRNAs in cancer and Proteoglycans in cancer. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is HOXA10.
UniProtKB/Swiss-Prot for HOXD10 Gene
-
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXD10 Gene
Genomics for HOXD10 Gene
Regulatory Elements for HOXD10 Gene
Enhancers for HOXD10 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HOXD10 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HOXD10 gene promoter:
Regulatory Element Products
Genomic Location for HOXD10 Gene
- Chromosome:
- 2
- Start:
- 176,108,790 bp from pter
- End:
- 176,119,942 bp from pter
- Size:
- 11,153 bases
- Orientation:
- Plus strand
Genomic View for HOXD10 Gene
Genes around HOXD10 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q31.1 by Ensembl
- 2q31.1 by Entrez Gene
- 2q31.1 by HGNC
HOXD10 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HOXD10 Gene
Proteins for HOXD10 Gene
-
Protein details for HOXD10 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P28358-HXD10_HUMAN
- Recommended name:
- Homeobox protein Hox-D10
- Protein Accession:
- P28358
- Q6NT10
Protein attributes for HOXD10 Gene
- Size:
- 340 amino acids
- Molecular mass:
- 38411 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for HOXD10 Gene
Other Protein References for HOXD10 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HOXD10
-
Custom Antibody ServicesOriGene Antibodies for HOXD10
- Novus Biologicals Antibodies for HOXD10
-
Abcam antibodies for HOXD10
- Invitrogen Antibodies for HOXD10
- antibodies-online Antibodies for HOXD10: See all 66
- GeneTex HOXD10 antibody for HOXD10
-
Santa Cruz Biotechnology (SCBT) Antibodies for HOXD10
Protein Products
-
OriGene Purified Proteins for HOXD10
- Search Origene for MassSpec and Protein Over-expression Lysates for HOXD10
- Origene Custom Protein Services for HOXD10
- antibodies-online Proteins for HOXD10: See all 11
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HOXD10
-
Abcam proteins for HOXD10
Assay Products
- antibodies-online Kits for HOXD10: See all 2
No data available for DME Specific Peptides for HOXD10 Gene
Domains & Families for HOXD10 Gene
Gene Families for HOXD10 Gene
Protein Domains for HOXD10 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HOXD10 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P28358- Family:
-
- Belongs to the Abd-B homeobox family.
Function for HOXD10 Gene
Molecular function for HOXD10 Gene
- GENATLAS Biochemistry:
- homeo box D10(4D),homologous to mouse Hox-4.5
- UniProtKB/Swiss-Prot Function:
- Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003682 | chromatin binding | IEA | -- |
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | IEA | -- |
| GO:0043565 | sequence-specific DNA binding | IEA | -- |
Phenotypes for HOXD10 Gene
- MGI mutant phenotypes for HOXD10:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for HOXD10:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXD10 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXD10 gene
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CRISPR Products
-
OriGene CRISPR knockouts for HOXD10
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXD10
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miRNA for HOXD10 Gene
- miRTarBase miRNAs that target HOXD10
miRNA Products
- Search ViGene Biosciences for HOXD10
Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for HOXD10 gene
Clone Products
-
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Cell Line Products
-
Horizon Cell Lines for HOXD10
-
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-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for HOXD10 Gene
Localization for HOXD10 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HOXD10 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| extracellular | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000932 | P-body | IDA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for HOXD10 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
| 2 | Proteoglycans in cancer | ||
Pathways by source for HOXD10 Gene
2 KEGG pathways for HOXD10 Gene
Interacting Proteins for HOXD10 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001501 | skeletal system development | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007338 | single fertilization | IEA | -- |
Transcripts for HOXD10 Gene
mRNA/cDNA for HOXD10 Gene
- (1) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (56) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HOXD10
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXD10
- GenScript: Design CRISPR guide RNA sequences for HOXD10
miRNA Products
- Search ViGene Biosciences for HOXD10
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HOXD10
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-
ViGene Biosciences ready-to-package AAV shRNAs for HOXD10 gene
Clone Products
-
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HOXD10
Flow Cytometry Products
Expression for HOXD10 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Mesenchymal Stem Cells (Uncategorized)
-
Limb (Muscoskeletal System)
- Progress Zone Cells Limb Bud
- Zone Of Polarizing Activity Cells Limb Bud
- Prechondrocytic Mesenchymal Cells Stylopod
- Limb Bud Mesenchyme Cells Limb Bud
- Umbilical Cord (Extraembryonic Tissues)
-
Kidney (Urinary System)
- Metanephric Mesenchyme Cells Metanephric Mesenchyme
- Renal Vesicle
- Metanephros
-
Bone (Muscoskeletal System)
- Sclerotome Cells Sacral Mesenchymal Sclerotome
- Progress Zone Cells Limb Bud
- Prechondrocytic Mesenchymal Cells Stylopod
-
Cartilage (Muscoskeletal System)
- Sclerotome Cells Sacral Mesenchymal Sclerotome
- Progress Zone Cells Limb Bud
- Prechondrocytic Mesenchymal Cells Stylopod
-
Mesoderm (Gastrulation Derivatives)
- Zone Of Polarizing Activity Cells Limb Bud
- Limb Bud Mesenchyme Cells Limb Bud
- Placenta (Extraembryonic Tissues)
- Blood (Hematopoietic System)
-
Somite (Muscoskeletal System)
- Sclerotome Cells Sacral Mesenchymal Sclerotome
-
Tendon amp Ligament
- Sclerotome Cells Sacral Mesenchymal Sclerotome
-
Spinal Cord (Nervous System)
- Lateral Motor Neurons Lumbar Lateral Motor Column
-
Neurons
- Lateral Motor Neurons Lumbar Lateral Motor Column
-
Ovary (Reproductive System)
- Ovarian Mesenchymal Stroma Cells Ovary Interstitium
-
Testis (Reproductive System)
- Testicular Interstitial Cells Testis Interstitium
-
Dermis (Integumentary System)
- Dermal Fibroblasts Dorsal Dermis
-
Fibroblasts
- Dermal Fibroblasts Dorsal Dermis
- Brain (Nervous System)
- Neural Tube (Nervous System)
- Trophoblast (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for HOXD10 Gene
This gene is overexpressed in Uterus (x13.3), Vagina (x7.8), Colon - Sigmoid (x6.9), Cervix - Ectocervix (x5.5), Kidney - Cortex (x4.9), and Prostate (x4.8).
NURSA nuclear receptor signaling pathways regulating expression of HOXD10 Gene:
HOXD10SOURCE GeneReport for Unigene cluster for HOXD10 Gene:
Hs.123070mRNA Expression by UniProt/SwissProt for HOXD10 Gene:
P28358-HXD10_HUMAN
Tissue specificity:
Strongly expressed in the adult male and female urogenital tracts.
Evidence on tissue expression from TISSUES for HOXD10 Gene
- Intestine(4.2)
- Nervous system(4.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXD10 Gene
Germ Layers:
- mesoderm
Systems:
- skeletal muscle
- skeleton
Organs:
Limb:
- ankle
- digit
- elbow
- finger
- foot
- hand
- hip
- knee
- lower limb
- shoulder
- toe
- upper limb
- wrist
Primer Products
-
OriGene qPCR primer pairs for HOXD10
-
OriGene qPCR primer pairs and template standards for HOXD10
No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for HOXD10 Gene
Orthologs for HOXD10 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HOXD10 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HOXD11 34 |
|
||
| HOXD10 35 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | HOXD10 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hoxd10 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Hoxd10 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HOXD10 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HOXD10 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HOXD10 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hoxd10 34 |
|
||
| Str.2493 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC68611 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hoxd10a 34 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for HOXD10 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HOXD10 Gene
Paralogs for HOXD10 Gene
(2) SIMAP similar genes for HOXD10 Gene using alignment to 1 proteins:
Variants for HOXD10 Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs104893634 | Pathogenic, Vertical talus, congenital (CVT) [MIM:192950] | 176,119,164(+) | CCGAA(A/T)GAAAC | reference, missense | |
| rs114746583 | Likely benign | 176,119,278(+) | GAGGG(G/T)GCACC | utr-variant-3-prime | |
| rs116807022 | Likely benign | 176,119,233(+) | TTAGG(C/T)CTGAG | utr-variant-3-prime | |
| rs144160937 | Likely benign | 176,119,206(+) | AGAAC(C/T)GACCG | reference, missense | |
| rs149038150 | Likely benign | 176,117,205(+) | CTCAT(G/T)TCGGC | reference, missense |
Residual Variation Intolerance Score:
42.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.29;
25.66% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HOXD10 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXD10 Gene
Disorders for HOXD10 Gene
(10) MalaCards diseases for HOXD10 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| vertical talus, congenital |
|
|
| congenital vertical talus, unilateral |
|
|
| congenital vertical talus, bilateral |
|
|
| syndactyly, type v |
|
|
| synpolydactyly |
|
|
Search HOXD10 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
HXD10_HUMAN- Vertical talus, congenital (CVT) [MIM:192950]: A rare malformation characterized by vertical orientation of the talus with a rigid dorsal dislocation of the navicular, equinus deformity of the calcaneus, abduction deformity of the forefoot, and contracture of the soft tissues of the hind- and mid-foot. This condition is usually associated with multiple other congenital deformities and only rarely is an isolated deformity with familial occurrence. {ECO:0000269 PubMed:15146389}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for HOXD10
No data available for Genatlas for HOXD10 Gene
Publications for HOXD10 Gene
- A HOX gene mutation in a family with isolated congenital vertical talus and Charcot-Marie-Tooth disease. (PMID: 15146389) Shrimpton A.E. … Hootnick D.R. (Am. J. Hum. Genet. 2004) 3 4 22 64
- HOX4 genes encode transcription factors with potential auto- and cross-regulatory capacities. (PMID: 1756725) Zappavigna V. … Duboule D. (EMBO J. 1991) 3 4 22 64
- High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 46 64
- MicroRNA-7, a homeobox D10 target, inhibits p21-activated kinase 1 and regulates its functions. (PMID: 18922890) Reddy S.D. … Kumar R. (Cancer Res. 2008) 3 22 64
- Absence of HOXD10 mutations in idiopathic clubfoot and sporadic vertical talus. (PMID: 17417092) Gurnett C.A. … Dobbs M.B. (Clin. Orthop. Relat. Res. 2007) 3 46 64
Products for HOXD10 Gene
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- antibodies-online Antibodies for HOXD10: See all 66
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- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HOXD10 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
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